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OTAR3088
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BioData-CellLine_annotated

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PMC9516447
The quantitation of the relative protein levels of SRC and p85 after normalization to the GADPH levels is shown in the graphs below.
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PMC11791203
Tannir et al. optimized the extraction of polyphenols from Cuminum cyminum seeds and evaluated their anticancer effects, showing significant activity (81%) against HT29 cells.
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PMC11755624
Psoriasis is a chronic and relapsing inflammatory dermatosis.
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PMC6461034
To overcome current limitations in information, our INKA pipeline provides a separate kinase‐centric ranking of kinases that are not yet covered by PhosphoSitePlus and NetworKIN, but do show up as phosphoproteins in a sample.
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PMC9581083
Ethanol extracts of S. divaricata showed anti-inflammatory activity by inhibiting the production of NO, prostaglandin E2 (PGE2), TNF-α, and IL-6 in LPS-induced RAW 264.7 cells (Chun et al., 2016).
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PMC11756907
Similarly, rGO-2ME shows higher anticancer efficacy against A375 cells than rGO (Figure 2C and D).
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PMC7039683
Periderm-specific NFRs lacking H3K27Ac at 8hpf or 24 hpf but associated with genes expressed in periderm may be enhancers that are active at another stage; consistent with the existence of such elements, a recent study shows the expression profile in zebrafish periderm changes over time (Cokus et al., 2019).
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PMC11248911
The complex was then equilibrated for stabilizing its temperature and pressure by subjecting it to NVT and NPT ensemble and simulating for 125 ps at 300.15 K temperature using 400 kJ mol nm and 40 kJ mol nm positional restraints on the backbone and side chains, respectively.
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PMC11392912
The production of reactive oxygen species (ROS) leading to increased oxidative stress was analyzed by DCFDA assay after normalising with cell count (Supplementary Figure S2).
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PMC8481254
We have previously demonstrated that HG enhances the stability of YAP and intracellular levels of O-GlcNAcylation, leading to enhanced YAP-dependent tumorigenic phenotypes.
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PMC11577421
Fluorescence anisotropy measurements of fluorescein-labeled heparin upon titration with BSA, BSA+ and BSA– at the indicated pH values.
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PMC9429973
Pts receiving ≥1 dose of GO were evaluable for QTc, safety, and PK.
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PMC10999934
These results further validated that FBXO2 may be a potential biomarker associated with chemoresistance in HGSOC.Fig.
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PMC11755519
LNMAT2 expression positively correlated with bladder cancer metastasis in a group of 266 patients studied; moreover, LNMAT2 overexpression correlated with shorter overall survival and disease-free survival.
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PMC11742670
Vidarabine was purchased from Masaaki Co., Ltd. Fukuoka West office.
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PMC11754094
The prepared mixture was added to the seeded wells.
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PMC9429973
Cycles are repeated every 4-8 weeks depending on count recovery and Ven is administered for 21 days in subsequent cycles, with dose adjustments as necessary depending on count recovery.
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PMC11188874
Supernatants were removed and used as cell lysates.
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PMC9917080
Similarly, sorafenib did not induce apoptosis after 24 h of incubation.
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PMC11803149
Error bars represent SD.
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PMC11525293
Actin was used as the loading control, and one representative experiment is shown.
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PMC11725127
A, B) MM.1S (A) or RPMI 8226 (B) cells were treated with the indicated compounds for 24 h. The protein levels of KRAS were then examined by Western blot.
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PMC8041314
Eventually, the intracellular fluorescence was detected via flow cytometry (Guava easyCyte HT, Merck Millipore, Billerica, MA, USA) at an excitation wavelength of 488 nm and emission wavelength of 695/50 nm.
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PMC11023271
The HaCaT cell line was a gift from Dr. Lisa Delouise (University of Rochester Medical Center).
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PMC11767725
Experimental interventions targeting lipid metabolism, such as fibrates and PPARγ agonists, demonstrated modest improvements in skin inflammation by restoring microbial equilibrium.
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PMC11763764
FGF401 (official name, roblitinib) is a highly selective potent FGFR4 inhibitor.
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PMC11247842
Besides the negative effect on milk yield and quality, mastitis is painful to the animal and often requires antibiotic treatment and, if persistent, may lead to early culling .
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PMC11092382
The next step in research may involve the assessment of sophocarpine across various dosages and administration routes to investigate its potential role in the treatment of Alzheimer’s disease.
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PMC9429973
In patients with PMR (4-DS) after 2 courses of treatment, the relapse frequency was significantly higher (47%) compared to the CMR (8%), р>0.05.
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PMC11055510
p < 0.05.
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PMC11705901
The expression level of GG genotype of rs1042778 was significantly lower than TT genotypes.
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PMC11499381
Interference with coupling of intracellular proteins to receptors could also alter the regulation of these receptors by preventing the interaction between β-arrestin and the receptor.
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PMC11791203
These proteins primarily regulate the permeabilization of the mitochondrial outer membrane and the release of cytochrome c (Cyt c) into the cytoplasm.
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PMC10877303
For the computation of binding free energy, the default macro file was modified, and the following equation was used:ΔGbind = ΔGcomplex(minimised) – [ΔGligand(minimised) + ΔGreceptor(minimised)]ΔGbind = ΔGMM + ΔGPB + ΔGSA − TΔS Here, ΔGMM denotes the sum of electrostatic and van der Waals interactions; ΔGSA and ΔGPB in...
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PMC11746948
Sample sizes: (e, j, l, n, q) n = 3 independent experiments.
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PMC11794588
Its anti-inflammatory properties could contribute to reducing lung cancer cell proliferation, possibly by inhibiting inflammatory pathways that promote cancer growth.
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PMC10812665
Washing of the 10 cm cell culture dishes was performed once with PBS, followed by quenching with 50% v/v methanol/H2O.
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PMC10940855
A–D,EFNB2 expression in patients with t(4;14) (A), amplification of chromosome 1q (B), hyperdiploid multiple myeloma (C), and high-stage disease (D) in two independent clinical studies.
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PMC10748106
Both iridoids differ in the GAPHOMO-LUMO, LogP, and dipole moment.
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PMC11462673
A Data from the GEO dataset GSE13159 revealed a significantly higher mRNA expression of LDB1 in T-ALL patients compared to bone marrow samples from healthy donors.
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PMC11551844
A study by Woźniak et al. (2017) on the size- and shape-dependent cytotoxicity profile of AuNPs for biomedical applications showed that different shapes of AuNPs have different UV visible absorption spectra.
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PMC11657695
Of all the genes encoding Kv1-type potassium channels, KCNA2 is the only one that is expressed in all ES cell lines (with the exception of the TC-71 cell line) but is not expressed in any OS cell lines.
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PMC11535726
The ITS, LSU and SSU sequence data of Kirschsteiniothelia species were retrieved and downloaded from GenBank (Table 1).
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PMC11756907
Human dermal fibroblast cells were grown in an incubator under the defined conditions: temperature 37°C, 5% CO2.
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PMC9429973
Subgroup analysis for PFS including gender, age, LDH, POD-24 and extranodal disease show no subgroup favoring RIT nor ASCT.
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PMC11653533
A different study showed that ethanolic leaf extract of F. racemosa has possessed cytotoxic activity against Dalton Lymphoma Ascites (DLA) cell line by MTT assay where 200 μg/ml extracts inhibited 57.37 % of cells and showed an IC50 value of 175 μg/ml (Khan et al., 2017).
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PMC11679892
A260/A280 and A260/A230 ratios were evaluated to determine the phenol, protein, and genomic DNA contamination that may occur during isolation.
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PMC10988555
Also, these complexes were shown to be nontoxic in vivo in an ex ovo chick embryo yolk sac membrane (YSM) assay.
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PMC9429973
There were slightly more men in the SC group (68.8%) than in the active cardiac monitoring group (53.9%), p = 0.026.
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PMC11532793
The effectiveness of the RTA-dispersion estimates in the edgeR pipeline will be determined more by their correlation with the true RTA-dispersions than by their absolute size.
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PMC11740573
The prepared suspensions were used for further experiments.
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PMC11627060
These differences indicate the successful formation of TQ-BSA NPs.
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PMC9786247
While the latter strain in turn significantly induced IL-6 transcription, milk isolates Z69/06, Cb28/6 and Cb33/4 showed a tendency to depress IL-6-transcription to a similar degree as the prototype strain NMI.
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PMC5963610
NGcGM3 has been recognized as an effective target for cancer therapy [15–17].
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PMC2614415
Aberrant expression and function of proteins that regulate the mitotic spindle, and other cell cycle checkpoints can lead to aneuploidy and contribute to cancer progression .
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PMC11033779
Gene expression profiling of normal breast tissue from this cohort has identified a pattern of gene expression differences that have been associated with the development of basal breast cancer and are also reflective of Hedgehog (Hh) signaling.
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PMC9031474
Especially, new synthetic methods could provide access to novel drimanes and coloratanes with enhanced cytotoxicity and selectivity .
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PMC9429973
J.-A. Georgi, S. Stasik, M. Kramer, C. Röllig, T. Haferlach, P. Valk, D. Linch, T. Herold, N. Duployez, F. Taube, U. Platzbecker, H. Serve, C. Baldus, C. Müller-Tidow, C. Haferlach, M. Meggendorfer, S. Koch, E. L. Boertjes, R. K. Hills, A. Burnett, G. Ehninger, K. Metzeler, M. Rothenberg-Thurley, A. Dufour, H. Dombret,...
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PMC11138140
For digital holographic imaging experiments, rat cardiac cells were cultured and treated with chemicals in 6-well plates (83.3920, Sarstedt, Nümbrecht, Germany) and then covered with HoloLids (PHI, Sweden) to stabilize imaging conditions.
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PMC11487720
However, neither event occurs in the UV or UV/cold shock-treated WWOXd cells.
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PMC11317131
n = 4. (
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PMC11548041
EpCAM expression.
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PMC11696576
A lower limit of quantitation (LLOQ) of 0.5 ng/mL was reached for all compounds in human plasma and linearity was good.
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PMC11781181
The software for controlling instrument and acquiring data was Analyst TF 1.7.1 (SCIEX, Comcord, Ontario, Canada).
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PMC9429973
Efficacy and safety data from the randomized, placebo-controlled HOPE trial demonstrated the effectiveness of voxelotor in increasing hemoglobin (Hb) levels and reducing markers of hemolysis.
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PMC11673128
As a matter of fact, our group previously discovered activation of RAS/MAPK and PI3K/AKT pathways as off-target resistance mechanisms to lorlatinib in a preclinical model of ALCL (i.e., AS4 cell line).
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PMC10490530
The photon output for hLuz was 32,615 photon/s/cm/sr, which was 3 times higher than Luz (11,106 photon/s/cm/sr), whereas the average background signal was 1413 photon/s/cm2/sr (Figure 1g).
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PMC10976516
Even though the mechanisms of OV function are still not fully understood, it appears that OV administration can safely cause regression in several human cancers through both: (1) direct oncolysis in which both infected tumor and, only by some specific OV types, simultaneous infected tumor-associated stroma cells underg...
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PMC9429973
No pharmacotherapies are approved for use in children, and therapies targeting the underlying cause of hemolysis are needed.
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PMC11686380
T1-weighted axial (a), fluid-attenuated inversion recovery axial (b), and T1-weighted sagittal images (c) showed no abnormalities at 8 years of age. (
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PMC9341513
Simulated 4C are shown for simulations using GM12878 chromatin states both with and without the insert (position indicated with green lines).
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PMC11528603
This compound strongly inhibited HeLa cells via the apoptotic and anti-proliferative mechanisms.
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PMC6133382
CHO-S and MGAT1 CHO cells were infected with 1 multiplicity of infection (MOI) of MVMp or MVMc and evaluated in triplicate.
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PMC9776316
In this study, through an NHEJ pathway-focused gene RNAi screen, we identified XRCC4 as an important NHEJ factor to promote resistance to cisplatin in ovarian cancer.
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PMC11588085
The lncRNA XIST controls XCI (X chromosome inactivation) in all somatic cells, so we investigated whether XIST downregulation was associated with XCI regulation in ovarian cancer cells.
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PMC9429973
Moreover, the expression of BCL-2, BAX, PARP, HSP70/90, MHC-I, and NLRP3 at mRNA was determined by using quantitative PCR (Q-PCR).
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PMC11695623
p < 0.05, **p < 0.01, ***p < 0.001.
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PMC11612508
The magnetic hysteresis curves see the high magnetic response to a changing magnetic field.
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PMC9429973
K. Kaluzskaya, Y. Polyakov, E. Baryakh, E. Gemdzhian, E. Misyurina, E. Zhelnova, K. Yatskov, O. Kochneva, T. Chudnova Moscow City Clinical Hospital 52; Russian Medical Academy of Continuous Medical Education; Federal State Budgetary Educational Institution of Higher Education “Russian National Research Medical Universi...
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PMC8010066
Two-way ANOVA and Tukey's tests indicated the significant effect of SA-1 on the lasI/R expression level and virulence factor production in PA-2 and PA-3, particularly in the biofilm state co-culture (P-value ≤ 0.001).
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PMC11615828
The same strategy was used to confirm that the immobilization of centriolar satellites or post‐Golgi vesicles did not affect the dynamics of other non‐overlapping vesicles (Figure S14 and Videos S16 and S17, Supporting Information).
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PMC11740508
We hypothesized that benefit for this drug combination would only be specific to HRR deficient tumors, due to their inability to enact high fidelity DNA repair with subsequent cell death.
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PMC9429973
NUC-7738 decreased the percentage of CD34 CD38 CD123 (LSCs) from 15% to 7% and significantly reduced the total number and size of leukemic colonies.
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PMC11777207
However, it had yet to be determined whether PD-L1 extracellular interactions, with either PD-1 or CD80 (5), participate in the regulation of DC migration or if the same PD-L1 regulation of DC migration is conserved in human DCs.
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PMC11594641
The RAB27A and RAB27B knockout (KO) cell lines were created via transfection of ribonucleoprotein complexes containing Cas9 nuclease (Thermo Fisher Scientific, Waltham, MA, USA) and a single guide RNA (sgRNA) (Edit-R CRISPR (knockout) Human synthetic sgRNA) (Horizon Discovery, Lafayette, CO, USA).
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PMC11718809
For example, circEZH2 influences cell proliferation, apoptosis, and lipid metabolism in bovine mammary epithelial cells .
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PMC11593084
A mAb with the specificity and epitope of PMab-117 has never been obtained by immunization with mice.
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PMC11756514
The mixture was centrifuged at 10,000 x g for 30 min at 4°C, and the supernatant was slowly diluted threefold in loading buffer (25 mM Tris-HCl, pH 7.8, 0.15 M NaCl, 25 mM CaCl2) to allow protein refolding.
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PMC11470999
Scale bar: 1 mm (left) and 50 µm (right).
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PMC10123657
Peptides were separated in nine fractions, each eluted with 100 μL of 2, 5, 7.5, 12.5, 15, 17.5, 20, 35, or 50% ACN in 15 mM ammonium hydroxide, pH 10.
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PMC11585587
There have been significant advances in the treatment of MM over the past 20 years, but it is still no cure completely.
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PMC11499381
Both these receptors were detected on the cell surface at similar levels to WT receptor complexes (Figures 3 and 4, Supplementary Figures S5 and S4).
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PMC9429973
All low-risk APML patients received ATO-ATRA in induction and consolidation.
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PMC11521786
This model is resistant to the 7A7 MAb specific to murine EGFR, partially due to the upregulation of murine ErbB3 (mErbB3) compared to the parental 3LL-D122 line (31).
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PMC11786767
Moreover, we analyzed the distribution of nuclear lipids after RO-3306 treatment.
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PMC11640476
However, for both low and medium cell confluences, the λEx-λEm combination of 545 nm as λEx and 590 nm as λEm yielded the greatest FI difference between the experimental well and the Blank (Figure 1).
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PMC11637284
Intriguingly, the TAC60-P185E mutant lost the capability to interact with mini-p166 (Fig 5B) suggesting that an α-helix with a kink in the center is required for TAC60-p166 interaction.
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PMC11682525
This research was approved by the Ethics Committee of Shiraz University of Medical Sciences, Shiraz, Iran (Approval Number: IR.SUMS.REC.1401.279) and the study was performed in accordance with Declaration of Helsinki To evaluate the expression of nestin and SOX10, which are among the markers of neural crest stem cells ...
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PMC11264242
Examples of IGV views of FLAG ChIP-seq in parental and SSX2-FLAG cells. (
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PMC10073922
For invasion assays, the transwell was coated with 100 μl (1 mg/ml) matrigel (BD Bioscience, Bedford, MA).
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