OTAR3088/BioData-CellLine_annotated · Data Studio

PMCID string	Sentences string	ner list
PMC9429973	Salvage therapy should be chosen considering the previous front-line therapy and is followed or not by auto or alloHSCT depending on the achievement of molecular remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11754784	The binding pattern between aptamer/Nb and different cell lines is shown in Supplementary Fig. 9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "binding", "pattern", "between", "aptamer/Nb", "and", ...
PMC6617630	Experiments were repeated three times and a representative image is shown Mechanistically, BETi interfere with MYC transcription by physically blocking binding of BRD proteins at regulatory elements that influence MYC expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	Active‐caspase area was quantified by manually thresholding for positive fluorescence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Active‐caspase", "area", "was", "quantified", "by", "manually", "thresholding", "for", "positive", ...
PMC9966931	In a 24-well plate, ten nauplii were disposed for each test in the presence of the prior solutions at the different concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC5716223	As already described , L6C5 myoblast cultures were maintained and subcultured in growing medium (GM) (DMEM with 4.5 g/l glucose and Corning glutagro™, w/o sodium pyruvate, Corning 10-102-CVR; 100 U/ml penicillin, 100 μg/ml streptomycin, Euroclone ECB3001D; 10% FBS, Gibco 10270).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	Treatment with chemotherapeutics decreases the expression of vtRNA 1-1, suggesting a possible marker for controlling this disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "chemoth...
PMC9621239	A schematic diagram of the functional domains of HBV X protein. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "schematic", "diagram", "of", "the", "functional", "domains", "of", "HBV", ...
PMC11727907	Consistently, the ratio between the dimeric and the tetrameric form of PKM2 was increased in ARPE-19 cells treated with IGF-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Consistently", ...
PMC11697189	RCC has a variety of pathological types, of which approximately 75% are clear cell renal cell carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RCC", "has", "a", "variety", ...
PMC11087301	Also, HCC cells lining the VM tubes were found to demonstrate stemness factors SOX2 and OCT4 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "HCC", "cells", "lining", "the"...
PMC11248911	Found: C, 57.79; H, 3.69; N, 10.16; S, 7.81.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Found", ":", "C", ",", "57.79", ";", ...
PMC11742670	The cytotoxicity was evaluated against three cancer cell lines, namely A-549, A-375, and A-431, and two normal cell lines namely OEC, and HSF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-...
PMC11802929	The physicochemical properties are tabulated for each residue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "physicochemical", "properties", "are", "tabulated", "for", "each", "residue", "." ] } ]
PMC11335267	By contrast, Alx3-deficient mice on a high-fat diet show attenuated weight gain and improved insulin sensitivity, compared to control mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "contra...
PMC11469524	For that reason, the intracellular signaling networks of two representative cell lines HBL-1 and OCI-LY3 were analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "For", "that", "reason", ",...
PMC11650848	Our previous analysis of these two systems highlighted altered gene expression of ZFP57 without isolation of the alternative isoforms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "analysis", "of...
PMC11144200	In vitro, LPS-RGD-Nb36-DOX exhibits a binding rate that appears to be comparable to that of Nb36 or anti-CTLA-4 mAb, and it can specifically bind to the CTLA-4 antigen on the surface of CD8 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	Adoptive T-cell therapy, in which autologous or allogenic T cells are infused into patients with cancer, has shown considerable promise.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adoptive", "...
PMC11591052	A total of 30,000 cells were seeded in 3 cm cell culture dishes one day before analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "30,000", "cells", "were...
PMC11129910	Loss of X chromosome may cause complete loss of function of tumor suppressor genes and result in individuals becoming more susceptible to cancer formation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	In addition, the lack of optimal AITL models in vitro greatly limits the basic research on the mechanism of disease occurrence and progression, and also hinders the development of new drugs and preclinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8992508	Selected molecules were further tested evaluating their effect on rhodamine 123 assay in the resistant K562/DOX cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selected", "molecules", "were", "further", ...
PMC6461034	Third, a table of drug–kinase relationships was populated using GDSC (Iorio et al, 2016), CCLE (Karaman et al, 2008; Davis et al, 2011), and Proteomics DB (Klaeger et al, 2017; Dataset EV6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9646302	The subsequent immunoprecipitate was treated with precooled immunoprecipitation buffer 5–6 times and 2× loading buffer was added; the interaction between LAPTM5 and RAC1 was detected using HA and FLAG antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	a. Lab will determine and record vehicle for preparation of drug solutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a.", "Lab", "will", "determine", "and", "record", "vehicle", "for", "preparation...
PMC7812570	Hence, we concluded that GPI-m36.4 has high potential to be further developed as a novel HIV-1 gene therapy that can be used alone or in combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	Transmission electron microscopy (TEM) (Tecnai 12, Amsterdam, Netherlands) was used to observe viral particles stained with 2% (w/v) phosphotungstate solution (pH 7.4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711663	Finally, the intensities within the ROI were discretized using a unified bin-width of 5, starting from the minimum normalized HU value of 0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11699178	Looking ahead, further exploration of the interactions between HIF-1α and other signaling pathways, as well as personalized treatment strategies in combination with GEM therapy, is warranted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11540664	Evaluation of patient efficacy was based on imaging information using the mRESIST criterion, and patient survival information was collected via telephonic follow-up.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Evaluat...
PMC10969097	Finally, GAD inhibits the MAPK pathway by inhibiting ERK1/2, which in turn regulates cellular processes such as cell growth, differentiation and programmed cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	Specificity was furthermore confirmed against a panel of 366 different ATPases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specificity", "was", "furthermore", "confirmed", "against", "a", "panel", "of", "366", ...
PMC9429973	At the time of transformation 31.3% patients had CLL Rai stage IV, 74.7% were ECOG< 2, while the median Cumulative Illness Rating Scale (CIRS) was 4 (range 0-16).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	In support of this, we observed that pan siRNA-mediated depletion of 14-3-3 proteins reduced the levels of HIF-1α by chromatin fractionation (Figs. 7H and EV5K) and decreased the binding of HIF-1α to the HREs of CA9 and PHD3, similarly to USP43 depletion (Fig. 7I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11128598	In all the cases, except in the glioblastoma cell line LN-18, CIs were below 1 indicating synergistic interactions (Figures 7, 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC11381192	Development and validation of a prognostic nomogram model. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Development", "and", "validation", "of", "a", "prognostic", "nomogram", "model", ".", "(" ] } ]
PMC8984067	The main phase was isomorphic to hexagonal NaYF4 (β-NaYF4, JCPDS 16-0344), and some were isomorphic to cubic NaYF4 (β-NaYF4, JCPDS 77-2042), with a small amount of unknown impurities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10654497	A–D) Small ladder diagram comparing patients with C1 and C2 subtypes regarding the three immune scores and tumor purity. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC9429973	Methods: We retrospectively analyzed 1034 adult patients from the UW/FHCRC registry database, who received treatment for AML or MDS-EB between the years 2005-2018.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	Tumour cells commonly achieve MDR phenotype through overexpression and/or increased activity of ABC transporters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumour", "cells", "commonly", "achieve", "MDR", "phenotype", "through"...
PMC11794847	To probe into their proliferative capabilities, we conducted CCK8, colony formation, and EdU assays (Fig. 2A–H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC10607604	We then studied desmoplakin expression and localization using immunofluorescence (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "studied", "desmoplakin", "expression", "and", "localization", ...
PMC11075223	which has been used to treat wind-heat headache, tooth pain, aphtha, sore throat, prolapse of anus and uterine prolapse in traditional Chinese medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779605	NS_HS_TUMORSIG_v1.0, NanoString Technologies, Seattle, WA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NS_HS_TUMORSIG_v1.0", ",", "NanoString", "Technologies", ",", "Seattle", ",", "WA", ",", ...
PMC9436459	Mulberrofuran Q (30) showed inhibitory activity against oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells, and its protective effect was more potent than the positive control carnosine .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	Data are derived from at least three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "derived", "from", "at", "least", "three", "independent", "experiments", "." ] } ]
PMC9516401	The effect of hydroalcoholic extracts on IDE activity We examined the effect of HEPV, HECC, HEPO, HEA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", ...
PMC9341513	Although the t(11;14) rearrangement is common, the breakpoint has not previously been mapped in this cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "t(11;14", ")",...
PMC11792090	We first screened a safe and effective anti-CD70 scFv to construct anti-CD70 CAR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "screened", "a", "safe", "and", "effective", "anti...
PMC11301095	Among PAM survivors, 2 received miltefosine treatment, which acts primarily by inhibiting protein kinase B and has shown efficacy against Naegleria fowleri , with high stability and low interaction risk when used in combination therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10092581	The same displacement outcome can be obtained by adding stoichiometric amounts of AgNO3 to [AuCl], right after dissolving the latter in 20 : 80 D2O/DMSO‐d6 (Figure 1, top spectrum); this silver additive is known for chloride abstraction, via AgCl precipitation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11434983	Cell growth inhibition by the novel complex was evaluated using an MTT assay on the A431 cell line overexpressing EGFR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "growth", "i...
PMC11637820	Patients were categorized based on their wound type, diabetic condition, and pre-treatment with antibiotics (Supplementary Table S1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", ...
PMC11543853	The studied viruses bind to different receptors at the cell surface and belong to distinct clades within the genus Enterovirus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "studied", "viruses", ...
PMC11727145	Generally, this study reported a robust method for the preclinical in vitro assessment of keratinocyte-based cutaneous cell therapies using DED models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generally", ...
PMC11672881	Thus, we used RNA sequencing to look at the genome-wide changes in gene expression induced by either TQ, CU, or their combination in A375 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC10502403	Fluorescently labeled anti-human TCR Vδ2 monoclonal antibody (mAb) (Clone B6), anti-human CD8a mAb (clone RPA-T8), anti-human CD3ε mAb (clone SK7), anti-human CD45 mAb (clone HI30), anti-human IFN-γ mAb (clone 4S.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	For all analyses, we scaled each TCR feature such that it would have mean 0 and variance 1 in the training dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC6450504	PTX loading into the liposomes did not change the complexation behavior of the liposomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PTX", "loading", "into", "the", "liposomes", "did", "not", "chan...
PMC9739791	Moreover, bodipy-based ligands showed absorption in green light (ca.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "bodipy-based", "ligands", "showed", "absorption", "in", "green", "light", ...
PMC11770199	Diagram of p14-positive cells fused with p14-negative cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Diagram", "of", "p14-positive", "cells", "fused", "with", "p14-negative", "cells", ".", "(" ] } ]
PMC11703992	Fig. 5The single-cell analysis of significant genes in GCA samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5The", "single-cell", "analysis", "of", "significant", "genes", "in", "GCA", "samples", ...
PMC5415764	However, the in vivo study on the tumor tissue distribution and penetration of iRGD modified LPNs should be carried out in future work.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11756937	Overall, our study contributes to a better understanding of the direct and indirect factors influencing the success rates of the reprogramming process, thereby, maximising the research potential of NIGMS Repository iPSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655536	The increased intensity indicated the quantity of lysosome increased significantly in HA-treated RPMI-8226, U266, MM.1S (Fig. 3D, E, Fig. S3B) and primary MM cells (Fig. S3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11763111	A Representative GSEA results, demonstrated significantly upregulation of naive-related genes in 4KO-LLT1 CAR-T cells versus 4KO CAR-T cells before and after tumor infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11380454	Each image provided is accompanied by quantitative data from flow cytometry analysis (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "image", "provided", "is", "accompanied", "by",...
PMC6024716	The work presented here describes the creation of the HEK293 cell line with OAZ1 deletion using CRISPR genome editing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "work", "presented", ...
PMC9429973	Bone mineral density in PET/CT3 was significantly reduced in all patients with NHL and in patients with advanced NHL diagnosis compared to PET/CT2 (respectively; p=0.001 and p=0.002).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806613	Scale bar, 10 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "10", "μm", "." ] } ]
PMC7612475	To assess whether the increased R-loops present in the SF3B1-mutant expressing cell line affects DNA replication, we examined replication fork dynamics using the DNA fiber assay (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470381	Resuspend 2 × 10 cells in 100 µL of nucleofection solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resuspend", "2", "×", "10", "cells", "in", "100", "µL", "of", "nucleofection", ...
PMC10926885	We investigated NDE1's expression level, prognostic impact, gene alteration, DNA methylation, protein interaction, m6A mRNA modification, ceRNA network, related gene and function enrichment, and immune‐related effects in pan‐cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727907	Each membrane was stripped (Restore PLUS Western blot Stripping Buffer, Pierce Biotechnology, Rockford, IL, USA) and probed for β-actin or GAPDH (Cell Signaling Technology, Beverly, MA, USA) to verify equal protein loading.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10998613	Schematic diagram of the PIE-FCCS setup (B) Illustrative examples of fluorescence intensity auto- and cross-correlation functions obtained from PIE-FCCS. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", ...
PMC9429973	To adjust for cross-study differences, propensity score weighting was developed using logistic regression analyses and used to balance demographic and clinical characteristics between the PEG arm and RAV and ECU arms from 301.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11533140	High-resolution mass spectra (HRMS) were taken in the ESI mode using a Waters Q-TOF system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High-resolution", "mass", "spectra", "(", "HRMS",...
PMC11126803	The current treatment for metastatic RCC mainly consists of antiangiogenic therapies/tyrosine kinase inhibitors, such as treatment with sunitinib and pazopanib, as well as vascular endothelial growth factor receptor which have been shown to be effective with curative effects (5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2193049	All plasmid constructs described in this study were based on the plasmid pS65T-C1 (Clontech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "plasmid", "constructs", "described", "in", "thi...
PMC11488203	Average diameters in [nm] are listed below the graph and differences in size were calculated as percentage between untreated control exosomes and their corresponding taxol-loaded exosomes (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	Since SS18-SSX1 condensates can be diffused with the treatment of 1,6-hex or high-temperature conditions, we next attempted to destroy SS18-SSX1 condensates and release SS18 condensates to rescue the expression of FGF2, CAV1, and DAB2, which are targeted by SS18 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841189	Total RNA was extracted from thyroid carcinoma tissues or cell lines and reverse transcribed to cDNA using the RNeasy Mini Kit (Invitrogen) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	In this context, HP1α-deficient cells over-expressed 348 genes and under-expressed 365 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "context", ",", "HP1α-deficient", "cells", "over-expressed", "...
PMC9429973	Accordingly, scRNA-seq analysis of MNCs showed increased frequencies of HSPCs and myelomonocytic precursors, a reduction of T cells (Fig 1f), and emergence of a monocyte population characterized by the highest expression of NF-kB signaling and its effectors MCL1 and BCL2A1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11477621	H NMR (400 MHz, CDCl3) δ 6.95 (dd, J = 4.1, 1.8 Hz, 1H), 6.83 (t, J = 2.1 Hz, 1H), 6.11 (dd, J = 4.0, 2.5 Hz, 1H), 4.28 (t, J = 7.3 Hz, 2H), 4.11 (q, J = 7.1 Hz, 2H), 2.42 (s, 3H), 2.26 (t, J = 7.5 Hz, 2H), 1.72–1.67 (m, 2H), 1.62–1.55 (m, 2H), 1.32–1.26 (overlap, 6H), 1.24 (t, J = 7.1 Hz, 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, it was observed pneumonia in 39% (16/41) of patients, treated by common antibiotic drugs and always solved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreove...
PMC11756907	3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was purchased from Sigma Aldrich (Poland) The malignant melanoma cells were grown in an incubator under the defined conditions: temperature 37°C, 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11512230	One of the possible causes of antibodies to PEG in the human population is the widespread application of PEG in the manufacturing of different products, including drugs and cosmetics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	Furthermore, kaempferol has not exhibited significant toxic side effects, making it a promising candidate for therapeutic applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "kaempferol", ...
PMC11734514	Akt expression decreased at 12 hours but had a slight increase at 24 hours (Figure 3A and C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Akt", "expression", "decreas...
PMC11770130	In the macrophage, the ASMase can induce ER stress via elevation of ceramide and oxidized-LDL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "macrophage", ",", "the", "ASMase", ...
PMC11513011	Fig. 6Expression of cleaved-Caspase-3 and E-cadherin in IHC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Expression", "of", "cleaved-Caspase-3", "and", "E-cadherin", "in", "IHC", "." ] } ]
PMC11755467	These studies underline a tight balance and importance of host cell miRNAs for HIV-1 replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "underline", "a", "tight", "balance", "a...
PMC11638288	However, the ability of the O-glycan sequence of the branched O-glycosylation site at threonine 225 (T225) of HA to bind to NKp46 is conserved among different strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	d The relationship between experimentally measured relative abundance of [10-formyl-THF] and E. coli growth rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "The", "relationship", "between", "experiment...
PMC7369657	143B cells were seeded in a 12-well plate at a density of 1 × 10 cells per well.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "143B", "cells", "were", "seeded", ...
PMC11301242	Neo-loops simultaneously involved ecDNA genes MYC and TRIB1 were formed due to 2.1Mb (chr8: 125.53M, +; chr8: 127.67M, -) and 1.2Mb (chr8: 127.76M, +; chr8: 128.99M, -) deletion (Fig. 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: To evaluate the safety and primary efficacy of CD33 CAR NK cells Methods: 5 qualified subjects with R/R AML aged between 18 and 65 years-old were enrolled and received round(s) of infusion of anti-CD33 CAR NK cells (6×10, 1.2×10 or 1.8×10 cells per round after the precondition with Fludarabine (30mg/m) and Cytoxa...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11409031	An analysis of the genetic terrain between low-risk and high-risk classifications was carried out utilizing the R package 'maftools' .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "analysis", ...

PMC9429973

Salvage therapy should be chosen considering the previous front-line therapy and is followed or not by auto or alloHSCT depending on the achievement of molecular remission.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11754784

The binding pattern between aptamer/Nb and different cell lines is shown in Supplementary Fig. 9.

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PMC6617630

Experiments were repeated three times and a representative image is shown Mechanistically, BETi interfere with MYC transcription by physically blocking binding of BRD proteins at regulatory elements that influence MYC expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11628904

Active‐caspase area was quantified by manually thresholding for positive fluorescence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Active‐caspase", "area", "was", "quantified", "by", "manually", "thresholding", "for", "positive", ...

PMC9966931

In a 24-well plate, ten nauplii were disposed for each test in the presence of the prior solutions at the different concentrations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC5716223

As already described , L6C5 myoblast cultures were maintained and subcultured in growing medium (GM) (DMEM with 4.5 g/l glucose and Corning glutagro™, w/o sodium pyruvate, Corning 10-102-CVR; 100 U/ml penicillin, 100 μg/ml streptomycin, Euroclone ECB3001D; 10% FBS, Gibco 10270).

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10914904

Treatment with chemotherapeutics decreases the expression of vtRNA 1-1, suggesting a possible marker for controlling this disease .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "chemoth...

PMC9621239

A schematic diagram of the functional domains of HBV X protein. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "schematic", "diagram", "of", "the", "functional", "domains", "of", "HBV", ...

PMC11727907

Consistently, the ratio between the dimeric and the tetrameric form of PKM2 was increased in ARPE-19 cells treated with IGF-1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Consistently", ...

PMC11697189

RCC has a variety of pathological types, of which approximately 75% are clear cell renal cell carcinoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RCC", "has", "a", "variety", ...

PMC11087301

Also, HCC cells lining the VM tubes were found to demonstrate stemness factors SOX2 and OCT4 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "HCC", "cells", "lining", "the"...

PMC11248911

Found: C, 57.79; H, 3.69; N, 10.16; S, 7.81.

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PMC11742670

The cytotoxicity was evaluated against three cancer cell lines, namely A-549, A-375, and A-431, and two normal cell lines namely OEC, and HSF.

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PMC11802929

The physicochemical properties are tabulated for each residue.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "physicochemical", "properties", "are", "tabulated", "for", "each", "residue", "." ] } ]

PMC11335267

By contrast, Alx3-deficient mice on a high-fat diet show attenuated weight gain and improved insulin sensitivity, compared to control mice.

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PMC11469524

For that reason, the intracellular signaling networks of two representative cell lines HBL-1 and OCI-LY3 were analyzed.

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PMC11650848

Our previous analysis of these two systems highlighted altered gene expression of ZFP57 without isolation of the alternative isoforms .

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PMC11144200

In vitro, LPS-RGD-Nb36-DOX exhibits a binding rate that appears to be comparable to that of Nb36 or anti-CTLA-4 mAb, and it can specifically bind to the CTLA-4 antigen on the surface of CD8 T cells.

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PMC11612626

Adoptive T-cell therapy, in which autologous or allogenic T cells are infused into patients with cancer, has shown considerable promise.

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PMC11591052

A total of 30,000 cells were seeded in 3 cm cell culture dishes one day before analysis.

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PMC11129910

Loss of X chromosome may cause complete loss of function of tumor suppressor genes and result in individuals becoming more susceptible to cancer formation .

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PMC9429973

In addition, the lack of optimal AITL models in vitro greatly limits the basic research on the mechanism of disease occurrence and progression, and also hinders the development of new drugs and preclinical trials.

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PMC8992508

Selected molecules were further tested evaluating their effect on rhodamine 123 assay in the resistant K562/DOX cell line.

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PMC6461034

Third, a table of drug–kinase relationships was populated using GDSC (Iorio et al, 2016), CCLE (Karaman et al, 2008; Davis et al, 2011), and Proteomics DB (Klaeger et al, 2017; Dataset EV6).

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PMC9646302

The subsequent immunoprecipitate was treated with precooled immunoprecipitation buffer 5–6 times and 2× loading buffer was added; the interaction between LAPTM5 and RAC1 was detected using HA and FLAG antibodies.

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PMC4270159

a. Lab will determine and record vehicle for preparation of drug solutions.

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PMC7812570

Hence, we concluded that GPI-m36.4 has high potential to be further developed as a novel HIV-1 gene therapy that can be used alone or in combination.

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PMC8623816

Transmission electron microscopy (TEM) (Tecnai 12, Amsterdam, Netherlands) was used to observe viral particles stained with 2% (w/v) phosphotungstate solution (pH 7.4).

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PMC11711663

Finally, the intensities within the ROI were discretized using a unified bin-width of 5, starting from the minimum normalized HU value of 0.

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PMC11699178

Looking ahead, further exploration of the interactions between HIF-1α and other signaling pathways, as well as personalized treatment strategies in combination with GEM therapy, is warranted.

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PMC11540664

Evaluation of patient efficacy was based on imaging information using the mRESIST criterion, and patient survival information was collected via telephonic follow-up.

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PMC10969097

Finally, GAD inhibits the MAPK pathway by inhibiting ERK1/2, which in turn regulates cellular processes such as cell growth, differentiation and programmed cell death .

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PMC10079526

Specificity was furthermore confirmed against a panel of 366 different ATPases .

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PMC9429973

At the time of transformation 31.3% patients had CLL Rai stage IV, 74.7% were ECOG< 2, while the median Cumulative Illness Rating Scale (CIRS) was 4 (range 0-16).

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PMC11377827

In support of this, we observed that pan siRNA-mediated depletion of 14-3-3 proteins reduced the levels of HIF-1α by chromatin fractionation (Figs. 7H and EV5K) and decreased the binding of HIF-1α to the HREs of CA9 and PHD3, similarly to USP43 depletion (Fig. 7I).

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PMC11128598

In all the cases, except in the glioblastoma cell line LN-18, CIs were below 1 indicating synergistic interactions (Figures 7, 8).

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PMC11381192

Development and validation of a prognostic nomogram model. (

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PMC8984067

The main phase was isomorphic to hexagonal NaYF4 (β-NaYF4, JCPDS 16-0344), and some were isomorphic to cubic NaYF4 (β-NaYF4, JCPDS 77-2042), with a small amount of unknown impurities.

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PMC10654497

A–D) Small ladder diagram comparing patients with C1 and C2 subtypes regarding the three immune scores and tumor purity. (

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PMC9429973

Methods: We retrospectively analyzed 1034 adult patients from the UW/FHCRC registry database, who received treatment for AML or MDS-EB between the years 2005-2018.

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PMC6160470

Tumour cells commonly achieve MDR phenotype through overexpression and/or increased activity of ABC transporters.

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PMC11794847

To probe into their proliferative capabilities, we conducted CCK8, colony formation, and EdU assays (Fig. 2A–H).

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PMC10607604

We then studied desmoplakin expression and localization using immunofluorescence (Figure 4).

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PMC11075223

which has been used to treat wind-heat headache, tooth pain, aphtha, sore throat, prolapse of anus and uterine prolapse in traditional Chinese medicine.

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PMC11779605

NS_HS_TUMORSIG_v1.0, NanoString Technologies, Seattle, WA, USA).

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PMC9436459

Mulberrofuran Q (30) showed inhibitory activity against oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells, and its protective effect was more potent than the positive control carnosine .

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PMC11352666

Data are derived from at least three independent experiments.

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PMC9516401

The effect of hydroalcoholic extracts on IDE activity We examined the effect of HEPV, HECC, HEPO, HEA.

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PMC9341513

Although the t(11;14) rearrangement is common, the breakpoint has not previously been mapped in this cell line.

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PMC11792090

We first screened a safe and effective anti-CD70 scFv to construct anti-CD70 CAR-T cells.

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PMC11301095

Among PAM survivors, 2 received miltefosine treatment, which acts primarily by inhibiting protein kinase B and has shown efficacy against Naegleria fowleri , with high stability and low interaction risk when used in combination therapy .

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PMC10092581

The same displacement outcome can be obtained by adding stoichiometric amounts of AgNO3 to [AuCl], right after dissolving the latter in 20 : 80 D2O/DMSO‐d6 (Figure 1, top spectrum); this silver additive is known for chloride abstraction, via AgCl precipitation.

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PMC11434983

Cell growth inhibition by the novel complex was evaluated using an MTT assay on the A431 cell line overexpressing EGFR.

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PMC11637820

Patients were categorized based on their wound type, diabetic condition, and pre-treatment with antibiotics (Supplementary Table S1).

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PMC11543853

The studied viruses bind to different receptors at the cell surface and belong to distinct clades within the genus Enterovirus.

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PMC11727145

Generally, this study reported a robust method for the preclinical in vitro assessment of keratinocyte-based cutaneous cell therapies using DED models.

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PMC11672881

Thus, we used RNA sequencing to look at the genome-wide changes in gene expression induced by either TQ, CU, or their combination in A375 cell lines.

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PMC10502403

Fluorescently labeled anti-human TCR Vδ2 monoclonal antibody (mAb) (Clone B6), anti-human CD8a mAb (clone RPA-T8), anti-human CD3ε mAb (clone SK7), anti-human CD45 mAb (clone HI30), anti-human IFN-γ mAb (clone 4S.

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PMC11785489

For all analyses, we scaled each TCR feature such that it would have mean 0 and variance 1 in the training dataset.

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PMC6450504

PTX loading into the liposomes did not change the complexation behavior of the liposomes.

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PMC9739791

Moreover, bodipy-based ligands showed absorption in green light (ca.

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PMC11770199

Diagram of p14-positive cells fused with p14-negative cells. (

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PMC11703992

Fig. 5The single-cell analysis of significant genes in GCA samples.

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PMC5415764

However, the in vivo study on the tumor tissue distribution and penetration of iRGD modified LPNs should be carried out in future work.

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PMC11756937

Overall, our study contributes to a better understanding of the direct and indirect factors influencing the success rates of the reprogramming process, thereby, maximising the research potential of NIGMS Repository iPSCs.

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PMC11655536

The increased intensity indicated the quantity of lysosome increased significantly in HA-treated RPMI-8226, U266, MM.1S (Fig. 3D, E, Fig. S3B) and primary MM cells (Fig. S3C).

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PMC11763111

A Representative GSEA results, demonstrated significantly upregulation of naive-related genes in 4KO-LLT1 CAR-T cells versus 4KO CAR-T cells before and after tumor infiltration.

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PMC11380454

Each image provided is accompanied by quantitative data from flow cytometry analysis (Fig. 1).

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PMC6024716

The work presented here describes the creation of the HEK293 cell line with OAZ1 deletion using CRISPR genome editing.

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PMC9429973

Bone mineral density in PET/CT3 was significantly reduced in all patients with NHL and in patients with advanced NHL diagnosis compared to PET/CT2 (respectively; p=0.001 and p=0.002).

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PMC11806613

Scale bar, 10 μm.

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PMC7612475

To assess whether the increased R-loops present in the SF3B1-mutant expressing cell line affects DNA replication, we examined replication fork dynamics using the DNA fiber assay (Fig. 3B).

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PMC11470381

Resuspend 2 × 10 cells in 100 µL of nucleofection solution.

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PMC10926885

We investigated NDE1's expression level, prognostic impact, gene alteration, DNA methylation, protein interaction, m6A mRNA modification, ceRNA network, related gene and function enrichment, and immune‐related effects in pan‐cancer.

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PMC11727907

Each membrane was stripped (Restore PLUS Western blot Stripping Buffer, Pierce Biotechnology, Rockford, IL, USA) and probed for β-actin or GAPDH (Cell Signaling Technology, Beverly, MA, USA) to verify equal protein loading.

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PMC10998613

Schematic diagram of the PIE-FCCS setup (B) Illustrative examples of fluorescence intensity auto- and cross-correlation functions obtained from PIE-FCCS. (

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PMC9429973

To adjust for cross-study differences, propensity score weighting was developed using logistic regression analyses and used to balance demographic and clinical characteristics between the PEG arm and RAV and ECU arms from 301.

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PMC11533140

High-resolution mass spectra (HRMS) were taken in the ESI mode using a Waters Q-TOF system.

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PMC11126803

The current treatment for metastatic RCC mainly consists of antiangiogenic therapies/tyrosine kinase inhibitors, such as treatment with sunitinib and pazopanib, as well as vascular endothelial growth factor receptor which have been shown to be effective with curative effects (5).

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PMC2193049

All plasmid constructs described in this study were based on the plasmid pS65T-C1 (Clontech).

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PMC11488203

Average diameters in [nm] are listed below the graph and differences in size were calculated as percentage between untreated control exosomes and their corresponding taxol-loaded exosomes (B).

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PMC11519567

Since SS18-SSX1 condensates can be diffused with the treatment of 1,6-hex or high-temperature conditions, we next attempted to destroy SS18-SSX1 condensates and release SS18 condensates to rescue the expression of FGF2, CAV1, and DAB2, which are targeted by SS18 protein.

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PMC7841189

Total RNA was extracted from thyroid carcinoma tissues or cell lines and reverse transcribed to cDNA using the RNeasy Mini Kit (Invitrogen) according to the manufacturer’s instructions.

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PMC11723947

In this context, HP1α-deficient cells over-expressed 348 genes and under-expressed 365 genes.

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PMC9429973

Accordingly, scRNA-seq analysis of MNCs showed increased frequencies of HSPCs and myelomonocytic precursors, a reduction of T cells (Fig 1f), and emergence of a monocyte population characterized by the highest expression of NF-kB signaling and its effectors MCL1 and BCL2A1.

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PMC11477621

H NMR (400 MHz, CDCl3) δ 6.95 (dd, J = 4.1, 1.8 Hz, 1H), 6.83 (t, J = 2.1 Hz, 1H), 6.11 (dd, J = 4.0, 2.5 Hz, 1H), 4.28 (t, J = 7.3 Hz, 2H), 4.11 (q, J = 7.1 Hz, 2H), 2.42 (s, 3H), 2.26 (t, J = 7.5 Hz, 2H), 1.72–1.67 (m, 2H), 1.62–1.55 (m, 2H), 1.32–1.26 (overlap, 6H), 1.24 (t, J = 7.1 Hz, 3H).

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PMC9429973

Moreover, it was observed pneumonia in 39% (16/41) of patients, treated by common antibiotic drugs and always solved.

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PMC11756907

3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was purchased from Sigma Aldrich (Poland) The malignant melanoma cells were grown in an incubator under the defined conditions: temperature 37°C, 5% CO2.

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PMC11512230

One of the possible causes of antibodies to PEG in the human population is the widespread application of PEG in the manufacturing of different products, including drugs and cosmetics.

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PMC11727062

Furthermore, kaempferol has not exhibited significant toxic side effects, making it a promising candidate for therapeutic applications.

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PMC11734514

Akt expression decreased at 12 hours but had a slight increase at 24 hours (Figure 3A and C).

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PMC11770130

In the macrophage, the ASMase can induce ER stress via elevation of ceramide and oxidized-LDL.

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PMC11513011

Fig. 6Expression of cleaved-Caspase-3 and E-cadherin in IHC.

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PMC11755467

These studies underline a tight balance and importance of host cell miRNAs for HIV-1 replication.

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PMC11638288

However, the ability of the O-glycan sequence of the branched O-glycosylation site at threonine 225 (T225) of HA to bind to NKp46 is conserved among different strains.

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PMC11026382

d The relationship between experimentally measured relative abundance of [10-formyl-THF] and E. coli growth rate.

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PMC7369657

143B cells were seeded in a 12-well plate at a density of 1 × 10 cells per well.

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PMC11301242

Neo-loops simultaneously involved ecDNA genes MYC and TRIB1 were formed due to 2.1Mb (chr8: 125.53M, +; chr8: 127.67M, -) and 1.2Mb (chr8: 127.76M, +; chr8: 128.99M, -) deletion (Fig. 4C).

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PMC9429973

Aims: To evaluate the safety and primary efficacy of CD33 CAR NK cells Methods: 5 qualified subjects with R/R AML aged between 18 and 65 years-old were enrolled and received round(s) of infusion of anti-CD33 CAR NK cells (6×10, 1.2×10 or 1.8×10 cells per round after the precondition with Fludarabine (30mg/m) and Cytoxa...

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PMC11409031

An analysis of the genetic terrain between low-risk and high-risk classifications was carried out utilizing the R package 'maftools' .

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