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OTAR3088
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BioData-CellLine_annotated

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PMC11707832
N.G. Beratis reported a notable elevation in α-mannosidase activity in the peritoneal fluid of patients with gynaecologic cancer compared to women with infertility, serving as control subjects, in a study conducted in 2004.
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PMC11388384
Based on this logic, a tissue would function as a set of interrelated but discrete cells, with a set of cell–cell boundaries that form topological barriers and influence morphogen diffusion.
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PMC11471176
For comparisons of the drugs, overlapping means and 95 % confidence intervals were deemed statistically insignificant differences, whereas non-overlapping means and 95 % confidence intervals were a clear proof of statistically significant difference.
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PMC11489351
Notch1 expression was normalized to tubulin loading control.
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PMC11512230
According to Table 1, both types of particles are captured by both tumor and healthy cells (Figure S3).
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PMC11155445
nicotianae have comparable activity with that of standard fungicides (Scheme 9).
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PMC10887351
The last subtype identified, β3-ARs, are excitatory receptors, localized in adipose tissue (both BAT and WAT), vascular endothelium, and the small intestine , and they differ from the β1- and β2-AR subtypes with respect to the sequence and pharmacological profile.
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PMC9444294
Novel IHC application on formalin-fixed, paraffin-embedded tumor tissue taken from tumors growing in the limbs of genetically engineered mice conditionally expressing the human SS18-SSX protein in Myf5+ cells.
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PMC9429973
Mainly, PTDs in this gene span exons 2 to 8-10 and their detection is based on long-distance genomic PCR with extracted DNA from bone marrow.
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PMC11451829
In the past, mouse models have been used to induce lesions similar to those in human pterygium.
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PMC11656048
Notably, ferroptosis inhibitor have shown significant suppressive effects on the antitumor activity of shikonin, indicating that ferroptosis may be critical pathways for shikonin to treat OS.
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PMC11674441
The spots were visualized and analysed using the automated ELISpot Reader 08 Classic (AID GmbH, Strasberg, Germany).
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PMC5415764
This finding aligned with the quantitative results obtained for intracellular PTX accumulation.
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PMC11706776
SK3, whose α subunit is encoded by the KCNN3 gene, has been shown to be involved in the development of bone metastasis in breast cancer , and overexpressed in prostate cancer or melanoma .
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PMC11438317
Clones grown under selection with blasticidin are obtained and those that have incorporated the mutation in homozygosis are selected by PCR and sequencing.
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PMC11547972
The introduction of immune checkpoint inhibitors (ICIs), often combined with TKIs or other ICIs, has significantly improved the prognosis for patients with metastatic disease.
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PMC6948907
These compounds induce reactivation of tumor suppressor genes that have been silenced during the course of neoplastic transformation (Roth et al., 2001).
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PMC11394112
DLBCL is a genetically complex hematological malignancy with two major subtypes, the activated B cell-like (ABC) and the germinal center B cell-like (GCB), that correlate with patient prognosis .
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PMC6379402
In the first step, we started with random solutions, in which values in Ginit are filled by a random number generator following uniform distribution.
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PMC11143482
This is also in line with the previous study by Costa et al. , where they found that OS cell line could metastasize to the lungs.
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PMC11185260
Taken together, these data indicated that the restoration of exogenous SMARCB1 via the scL-SMARCB1 nanocomplex effectively suppressed the growth of SMARCB1-deficient tumors.
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PMC11585994
Next, we designed an additional siRNA targeting the 3’ UTR of BCL11B, alongside the siBCL11B-671 and siBCL11B-935 sequences targeting the CDS region.
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PMC9960565
C 27.60, H 4.83, N 12.60, found: C 21.93, H 5.71, N 10.60 (hygroscopic compound).
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PMC11487720
UV, on the other hand, increases cell membrane permeability, allowing rapid DAPI accumulation in the cytoplasm.
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PMC7757104
In ACRP cells, the expression levels of the epithelial markers E-cadherin, claudin-3 and cytokeratin-18 were upregulated compared with those in A2780 cells (Fig. 3A).
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PMC11462673
A Distribution of LDB1 binding to genomic regions in the 6 T-CEM cells, as assessed by CUT&Tag.
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PMC11352666
Navitoclax targets BCL-2 and BCL-XL and has been widely examined in combination with other therapies in numerous solid tumors, including rhabdomyosarcoma, small cell lung cancer, and endometrial carcinoma, and in hematologic malignancies including AML and ALL .
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PMC11200978
In this study, we investigated the A549 lung carcinoma cell line response to freezing.
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PMC10317042
After 24 hours of treatment, the cells were washed twice with cold PBS + 0.04% BSA, and 1 × 10 cells were used for nuclei isolation according to the manufacturer's protocol (version CG000365 Rev B).
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PMC10079526
E MCODE was used to extract the most interconnected clusters from the STRING network analysis in D. Cluster 1 represents proteins involved in chromosome organization and negative regulation of transcription.
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PMC10523483
Representative images (Left) and quantification (Right) of soft agar colony formation.
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PMC11641532
To predict cellular differentiation, cells were ordered in pseudotime using Monocle2 (v2.26.0) .
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PMC11354225
Cells were maintained in a humidified incubator at 37 °C with 5% CO2.
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PMC9545714
However, in the high TEWL cohort, GTE supplementation significantly reduced TEWL by 16 weeks.
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PMC5925824
LY3300054 was also tested in combination with anti-CTLA4 antibody (Ipilimumab) at equimolar concentrations ranging from 0.003 to 67 nM. After incubation for 72 h at 37 °C at 5% CO2, supernatants and cell pellets were harvested and subjected to immunoassay (human IFN-γ ELISA (R&D Systems) or 41-plex Milliplex MAP Human Cytokine/Chemokine Immunoassay Panel (Millipore, Burlington, MA) (analytes are listed in Additional file 2) and a custom-made Quantigene Plex gene expression analysis (see below).
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PMC10812665
Ber was, on the one hand, described as a mitochondrial inhibitor, but on the other hand, it is considered to be safe for human use.
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PMC8481254
Next, we intended to determine whether the antitumor activity of CA exerted by downregulating global O-GlcNAcylation levels and YAP expression is dependent on CDK19.
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PMC3164356
A difference between human and CHO glycosylation is seen in the lack of expression of MGAT3, which is responsible for the bisecting β(1,4) GlcNAc that occurs on ∼10% of human antibodies. (
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PMC11049548
For the exo-metabolome analysis, 1 mL of the growth medium was centrifuged in order to eliminate non-attached cells.
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PMC11279397
It serves as a crucial parameter for objectively assessing both the oral bioavailability and intrinsic quality of a drug, while also serving as a pivotal criterion for determining its potential as a therapeutic agent.
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PMC11564405
The TIP database developers, in a formidable computational endeavor, previously derived the pan-cancer immunophenotype from an expansive dataset comprising 11,373 samples that traverse the landscape of 33 distinct TCGA human cancers .
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PMC9454852
This cancer is strongly related to asbestos exposure and shows a very inauspicious prognosis, because there are scarce therapeutic options for this rare disease.
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PMC11676674
CHO-K1 cells were cultured in Ham’s nutrient F12 medium supplemented with 1% glutamine, 10% fetal bovine serum (FBS), and 1% penicillin/streptomycin.
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PMC11680562
CuO NPs were synthesized using Trichosanthes dioica dried seeds extract and incorporated into a pectin-xanthan gum-based gel.
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PMC10213199
Table 1Differentiated genes when compared with the control.
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PMC11742670
That is to help in the drug repurpose process in the next phase of the proposed model.
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PMC6600253
Therefore, previous studies, including ours, have suggested that PT inhibits hTERT expression and activity, leading to replication stress, S phase arrest, and senescence that depends on the status of p53 in lung cancer cells .
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PMC11612794
IC50 was calculated using GraphPad Prism by fitting the data to a sigmoidal dose-response curve with a 4 parameter logistic (4PL) model, where the X-axis represents the logarithm of the concentration.
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PMC11755519
The exosomes tested may enhance cancer cell proliferation and invasion and activate FAK and PI3K/AKT signaling.
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PMC11286266
It has been reported that ATF6α can exist in three redox forms: a monomer and two inter-chain disulfide-stabilised dimers (Nadanaka et al., 2007).
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PMC11543935
Figure 5D, E display the result of the fluorescence intensity measurements for the AlamarBlue assay of NIH3T3 and HCC-827 cells treated with the STIMULATE device.
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PMC2777936
Since the duration of siRNA-mediated repression might not be sufficient for the 6-day study time course, stable repression of FZD5 and FZD7 was sought using lentiviral shRNA infection of targeted cells.
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PMC7612475
To investigate this further, we assessed the efficiency of DNA repair using γH2AX as a marker of DSBs in control and SF3B1-depleted cells following exposure to IR.
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PMC11762280
Similarly, UVB-induced skin injury also manifests as epidermal necrosis and inflammation in pathological features, but the role of PANoptosis in keratinocytes in UVB-induced skin injury remains unclear.
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PMC11200978
Based on the observed increase in necrotic levels in combination-treated samples with little change in apoptotic levels, protein analysis was conducted to determine if the activation of necroptosis contributed to this increase.
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PMC11802929
We calculated 45 properties for each cell’s TCR sequences, including charge, hydrophobicity, weight, bulkiness, polarity, for three regions of CDR3β (V, J, CDR3βmer), as well as full CDR3α chain.
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PMC11552389
After 24 days, tumors were excised, measured, photographed.
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PMC10589262
Because of drastic cell death after 24 h of treatment with 5 µM TG, the activation status of ATF6, IRE1α, and PERK was measured for up to 8 h. The expression of CHOP (a cell death-related marker) and MT-KIT was also measured.
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PMC10882807
Recent Studies have demonstrated that EIF4A3 binds to the upstream region to promote circMMP9 expression, showing an important role in mRNA splicing .
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PMC9503669
Thus, finding a cure for HIV-1 infection is of paramount importance to global health.
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PMC11672617
Many of these compounds serve as proteasome regulators , activate the vitamin D receptor, and enhance the interaction between cholecalciferols and the receptor , exhibit inhibitory activity against DNA polymerases β (pol β) , and have antibacterial and antitumor effects .
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PMC9429973
Image: Summary/Conclusion: Although fever onset following ASCT was present in half of the patients in our population, in less than 40% duration was more than 72 hours.
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PMC11632064
See also Fig S4. (
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PMC11194678
A similar phenotype was observed in cultured hippocampal neurons with STAU1 knockdown (KD) by RNA interference (Lebeau et al., 2008).
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PMC11519567
Separate the beads with a magnet until the supernatant is clear.
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PMC9429973
Achieving MRR with frontline regimen does not significantly affect overall outcomes with the second-line therapy.
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PMC9065483
Total cell lysates were collected 24 hpi and probed for phosphorylated STAT1, total STAT1, phosphorylated STAT2, total STAT2, and GAPDH by western blot.
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PMC11704135
Furthermore, the sulfoxidation process applied to compounds 13 and 14, which involves the introduction of an oxygen atom, may have altered the overall spatial arrangement and electronic characteristics of the molecules.
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PMC9688728
These metabolites may support the rapid growth of tumor cells by providing nucleotides, amino acids, and cofactors as building blocks for nucleic acid and protein synthesis, as nutrient signaling agents, neurotransmitters, epigenetic modifiers, and energy sources.
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PMC11224020
Interestingly, a population of CCR7 DCs was recently described as residing within tumors; it remains unclear whether these cells trigger tolerogenic or antitumoral responses.
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PMC8526701
Left, representative staining pictures; Right, active caspase 3-positive cells were counted and plotted, Scale bar: 25 μm.
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PMC3203927
Compared to cluster analysis such as Principle Component Analysis (PCA), LDA requires prior knowledge of the classes, which fitted our purpose of study.
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PMC11754094
Neither the PacBio single-molecule real-time (SMRT) sequencing nor ONT nanopore sequencing platforms for long-read sequencing have sufficient sequencing accuracy (PacBio ~10% and ONT 2%–15%) to distinguish 1-bp deletion, 1-bp insertion and substitution events.
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PMC11743316
The significance of mitochondria is not confined to cellular metabolism; it has also been shown to be directly involved in maintaining cell viability by controlling cell death through apoptosis and maintaining cell viability through autophagy.
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PMC11787651
HDACis (entinostat and M344) were purchased from Selleck Chemicals as a 10 mM stock solution.
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PMC11349530
Instead, tumor-derived PD-L1 promotes metastasis independent of primary tumor growth by suppressing inflammatory and CTL-driven responses within immunosuppressive niche, which are created through PD-L1 engagement with PD-1 on myeloid cells (22).
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PMC6889484
CEM/D128K cells express endogenous A3G and A3F, but CEMSS cells do not.
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PMC10654497
Finally, the clinical staging of C2 subtype is mainly in stage IB, while the staging of C1 subtype is mainly in stage IA.
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PMC11678841
Our results show that C. albicans induced significant expression of P-MKK3/6; such expression was significantly reduced by pre-treatment with 10 µM GA (Figure 4A,B).
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PMC11532793
The optimal accuracy achievable by bootstrapping, however, is generally lower than that for Gibbs sampling, especially for larger experiments with more RNA samples.
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PMC10196713
no. 12592-1-AP; Thermo Fisher Scientific, Inc.) overnight at 4°C followed by treatment with anti-rabbit IgG antibodies (1:500; cat.
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PMC11190538
The findings are consistent with those of Hamed et al. , who found that the viscosity of stirred yoghurt held at 5 °C increased from day 1 to day 7.
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PMC9844987
Features are ordered by their average contribution to the prediction of highly variable promoters and selected TFs are highlighted.
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PMC9429973
Protein aggregation, reactive oxygen species (ROS) and glutathione (GSH) levels were determined by Thioflavin T, DCFH-DA and Thioltracker Violet fluorescence, respectively.
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PMC4131618
Eleven new secoiridoid aglycones involving unusual C9-skeleton: swerimilegenins A-F (1–6); bis-C9-skeleton: swerimilegenin G (7); and C10-skeleton: swerimilegenins H-K (8–11), as well as six known ones, were isolated from the low-polarity part of the traditional Chinese herb medicine Swertia mileensis.
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PMC11045125
Here we use an EBNA2-deleted EBV virus (ΔEBNA2 EBV) to create the first in vivo model for EBV+ BL-like lymphomas derived from primary human B cells.
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PMC11628904
This method allows for reproducible, localised epithelial damage, which is evident by the entry of cell impermeable dye only in tissue directly impacted by burn injury (Figure 1A).
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PMC11597291
Following this, the mixture was gently stirred at ambient temperature for 24 h in the dark.
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PMC10092581
These results are coherent with those highlighting their ability to target TrxR and support the hypothesis that TrxR represents a major cellular target for this class of complexes.
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PMC5415764
Complex purification procedures were involved in these reports.
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PMC5839394
Moreover, AgNPs-EPS treatment inhibited migration and invasion capability of tumoral cells, considered as a cancer hallmark, suggesting a potential anticancer effect.
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PMC9429973
Methods: Retrospective study of 142 patients over 60 years with hematological neoplasms undergoing allogeneic HSCT Results: Patient characteristics and survival curves are shown in Image 1.
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PMC11768927
Mice were treated with either anti-PD-1 or anti-CTLA-4 antibodies, alone or in combination with VSV engineered to express tumor-associated antigens.
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PMC9429973
Aims: 1)Assessment of CD 26 expression in suspected cases of CML-chronic phase 2)Correlation of CD 26+ stem cells with clinico-pathological parameters at baseline and its kinetics on tyrosine kinase inhibitor (TKI) treatment on further follow-up at 12 months.
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PMC9429973
All articles were reviewed by 2 independent abstractors.
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PMC9927933
On the other hand, unlike UBE2C knockdown, UBE2S knockdown had no effect on MAPK and mTORC signaling in A427 cells, whereas inactivated mTORC appeared to be independent of DEPTOR in H1792 cells (Supplemental Figure 3D), largely consistent with its lack of effect on the growth of lung cancer cells upon depletion (Supplemental Figure 1, E and F).
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PMC11802855
Additionally, the average trabecular thickness (Tb, Th) was significantly decreased in the CXCL7-OE group (P = 0.037), indicating that CXCL7 overexpression accelerates bone loss and disrupts trabecular structure.
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PMC11012012
They found that SLAMF receptor deficiency triggered macrophage phagocytosis of hematopoietic cells.
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PMC11298021
Propidium iodide (PI) dye (BD Biosciences, Bedford, Massachusetts, United States) binds to DNA without sequence specificity.
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PMC4395774
In comparison to animals reconstituted with mutant perforin (PGK.PRFmut), we observed that animals with ≥30% chimerism of perforin gene-corrected cells (either PGK.PRF or PRF.PRF, ranging from 33 to 92%, with a median chimerism of 72 and 47%, respectively) showed partial restoration of antigen-specific CTL killing and displayed significantly lower serum IFN-γ levels (Figure 6a,b).
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