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OTAR3088
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BioData-CellLine_annotated

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PMC9583612
Cusworth et al. showed that the average persistence of large emissions is only about 26%, suggesting the need for continuous measurements to detect and mitigate such events.
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PMC11349530
A pattern can be identified in which these factors cause the recruitment of various myeloid cells into the tumor tissue, which acquire an immunosuppressive phenotype in the tumor microenvironment, triggering a chain of further suppression of immune functions.
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PMC10094712
RNA isolation and reverse transcription were performed as described above.
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PMC10969097
For example, a study using grifolin (a secondary metabolic product isolated from the Albatrellus confluence mushroom) on human ovarian cancer cell lines (A2780) showed that this compound was capable of suppressing cell viability, inducing apoptosis and cell cycle arrest.
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PMC11615101
The panel showing WB images of α-Taxilin after transfection with different doses (25nM and 50nM) of Si-RNA along with GAPDH loading control (lower panel). (
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PMC10587429
However, breeder cages need to be set up in-house and closely monitored for multiple new litters within a narrow time frame for enough pups needed for experiments.
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PMC11703992
The R [R = 2*EAF*(1-EAF)*Beta, EAF: Effect Allele Frequency; Beta: Effect size] of each SNP was calculated summed them up to estimate the overall F statistics [F = R*(N − 2)/(1 − R), N: number of samples in the exposure GWAS data].
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PMC11672142
The Fe(III) redox behavior in Fe(DefNEtTrp)2 and Fe3(DefNEtTrp)2 provides coordination and activity insight.
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PMC9532503
The best performing primary clone (CHOSI Rit H3) was chosen for further sub-cloning by serial dilution on 96-well plates.
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PMC8584319
Under these experimental conditions, AZD8055 treatment in wild-type MEFs did not change the phosphorylation of eIF2α (Figure 1e).
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PMC3765139
In this study, a panel of heterogenous melanoma cell lines was screened for typical CSC features.
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PMC7369657
The expression of PARP1 was significantly lower, and cleaved-PARP1 was significantly higher in 143B cell line treated with CQDs compared with the control group.
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PMC11743975
The cells were exposed with both niclosamide and blue light to induce the aggregation of fragmentated mitochondria in the cells.
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PMC11742290
Together these studies support the hypothesis that high LGR5 expression is associated with cancer progression and metastasis.
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PMC8973725
Cleaved-caspase-3, cleaved-caspase-9 and cleaved-PARP were increased in the ZNF677(+) group cells and not in the control cells, while apoptosis protein BCL-2 was decreased.
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PMC11754784
Median values of fluorescence intensity in flow cytometry analysis were used.
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PMC9429973
In competitive repopulations with grafts with different ratio of JAK2V617F, JAK2V617F/TP53KO and wild type cells, we observed that JAK2V617F/TP53KO cells outcompete JAK2V617F cells.
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PMC9398137
Genetic alterations of BCL2, as well as high BCL2 protein expression are found in subsets of DLBCL and have been repeatedly associated with poor outcome (10, 33–35).
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PMC5941560
However, some of the better-studied mutations, such as those reported as pathogenic by ClinVar, are likely to have significant effects on important signaling pathways.
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PMC11549062
Carotid VSMCs were cultured in DMEM medium and incubated with a 50 μmol/L EdU solution (C10086; Invitrogen, USA) for 2 h. Following incubation, the cells were fixed with 4% paraformaldehyde for 30 min and treated with 2 mg/mL glycine for 5 min.
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PMC11678130
The cell nuclei were stained with DAPI (diluted in 0.1% BSA at a concentration of 300 nM) for 5 min at room temperature, F-actin with Texas Red-X phalloidin (diluted to 0.5:200 in 0.1% BSA) for 45 min at room temperature, and tubulin with alpha-tubulin monoclonal antibodies (B-5-1-2) (dilution of 1:1000 in 0.1% BSA) for 4 h at room temperature and goat anti-mouse IgG (H+L) secondary antibodies (Alexa Fluor™ 488) (dilution of 1:500 in 0.1% BSA) for 45 min at room temperature, as previously described .
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PMC9429973
Results: The median age of pts was 61 years (18 – 80 years) and 48% were female.
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PMC11128598
γH2AX foci were visualized by confocal microscopy.
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PMC9429973
Among the 10 pts on zanubrutinib with ≥90 days of follow-up, 80% achieved at least stable disease and 70% achieved a deepening of response.
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PMC11594074
This assay was conducted using the KG-1 cell line, which was stably transfected with the luciferase firefly gene coding for a light-emitting enzyme and cultivated in RPMI-1640 medium supplemented with 10% fetal bovine serum (FBS), 1% penicillin, and 0.5 mg/mL of geneticin.
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PMC6222635
No papers have reported the structure and anti-tumor activity differences in polysaccharides from Dendrobium officinale grown under different conditions.
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PMC9429973
Results: Univariate analysis Compared to outpatients, those admitted to hospital were more likely to be men (58.9% vs. 45.2%, p=0.003), older than 70 years (61.3% vs. 29.0%, p<.001), with at least one comorbidity (79.7% vs. 55.5%, p<.001) and a history of thrombosis (26.5% vs. 16.6%, p=0.008).
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PMC9429973
IC50 was determined based on proliferation.
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PMC8922418
Compared with the CRISPR-Cas genome editing method which induces HDR, PE has fewer off-target effects and byproducts, and higher editing efficiency.
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PMC11781181
Overexpression of miR-375-3p also upregulated ALOX15, LPCAT3, and FASN, but downregulated FADS2, SCD1, and SREBP1 expression in keratinocyte (P < 0.05) (Fig. 5F, G).
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PMC11473843
Immunoblot for the indicated targets in A549 cells treated as in (A).
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PMC11088135
The data indicated that compared with the control-plasmid group, YAP1-plasmid significantly enhanced the proliferation of U251 cells (Fig. 8A), reduced cell apoptosis (Fig. 8B, C), decreased Bax expression (Fig. 8D, E), and enhanced Bcl-2 expression (Fig. 8D, F).
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PMC9429973
The diagnosis of CML was confirmed by the presence of the Philadelphia chromosome and the detection of the bcr-abl fusion transcript at 86%.
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PMC11658074
UVB radiation triggers the MAPK/NF-κB pathway to increase MMP synthesis and suppresses the TGF-β/Smad pathway to decrease collagen expression .
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PMC11628904
C. albicans strains used in this study can be found in Table 1 below.
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PMC11739504
Black arrowheads indicate glomeruli.
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PMC11502443
However, the links between some of these molecules and the Gαq signaling are tenuous and further research is required to elucidate these connections (Baggio and Drucker, 2007; Mayendraraj et al., 2022).
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PMC6034753
As a transcriptional regulator, Meq has a nuclear distribution and can function as a Meq/Meq homodimer or a heterodimer with a number of other cellular BZIP proteins.
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PMC11306331
n.s.:
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PMC11618052
They worked better than the standard drug Erlotinib (IC50 = 80 ± 5 nM).
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PMC9429973
Methods: FV vectors expressing the anti-CD19 CAR from an EFP1 promoter were constructed.
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PMC10165258
On the other hand, droplets also introduce limitations on the duration of cell culture because of their limited volumes.
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PMC11055323
The result of staining was observed with a fluorescence microscope system ZEISS, and the data were collected by the ImageJ software.
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PMC11594641
For each independent experiment, two to four inserts per condition were used.
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PMC11413393
NEB stranded mRNA libraries were constructed and paired-end (100 bp) next generation sequencing was performed on a Illumina NovaSeq 6000 S4 system.
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PMC11470999
Based on the UPS, strategies such as molecular glues and proteolysis‐targeting chimeras (PROTACs) have been developed and they have shown promising anticancer potentials.
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PMC10932641
After 2 weeks or obvious colony formation, cells were washed with phosphate-buffered saline (PBS), fixed with 4% formaldehyde, and stained with 0.1% crystal violet.
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PMC9429973
Methods: A 12 year-old female was hospitalized for hypermenorrhea, drop attack, fatigue and leukocytosis.
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PMC8973725
The relative expression levels of ZNF677 proteins in 60 ccRCC tissues and 47 normal tissues were measured by IHC.
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PMC11740399
Second, the benefits of 3025@ML in combination with other chemical drugs were not investigated, such as gemcitabine, methotrexate, and docetaxel, which are also used to treat bladder cancer.
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PMC11541241
In a recent study, scientists investigated a gene expression profile in F. oxysporum upon FoTOR inhibition.
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PMC11805741
McCall et al. 2018 found that applying astaxanthin significantly reduced proliferation rates and inhibited the migration of breast cancer cells when compared to normal breast epithelial cells in the control group (McCall et al. 2018).
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PMC11596967
Following these are aliphatic and hydrophobic amino acids like Leu (L), Ala (A), and Val (V), which make up 24.9%.
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PMC9874064
After verifying the anti-tumor activity and DNA damage of NP-Pt-USP1i in vitro, an abdominal nude mouse tumor model based on BEL-7404DPP-LUC cells was constructed for studying the anti-tumor activity of NP-Pt-USP1i in vivo.
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PMC9429973
-MMRD (446 vs 373): an increase in activity in all months, with a final 19.5% increase.
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PMC11672142
This finding is important in the context of the cytotoxic behavior exhibited by DefNEtTrp as later discussed.
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PMC10975211
These peptide drugs serve as radionuclide carriers (b, g-emitters) and inhibitors of angiogenesis, cytotoxic medicines, and fluorescence probes (visible, Near-IR, Far-IR).
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PMC11467964
The siRNA sequences are as follow: siPSAT1#1: 5′‐CCCUAAACUUGGGAGUUAU‐3′, siPSAT1#2: 5′‐ACTCAGTGTTGTTAGAGAT‐3′. The siRNA was purchased from the Hanheng Biotechnology (Shanghai, China).
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PMC11519583
Any samples or animals were not excluded from the analysis.
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PMC11394386
Consistent with Protein Atlas data, prior studies reported β-catenin overexpression in up to 67% and GSK3β inactivation in up to 56% of CC cases.
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PMC9429973
CAR-T treatment failure was defined as the earliest of death, initiation of subsequent line of therapy, or documented progression event after CAR-T. Results: A total of 97 CAR-T patients were identified whereby 17 received CAR-T therapy in a clinical trial setting and were excluded from this real-world evidence study.
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PMC11747885
Additional analysis revealed that Rlig1 inhibition under oxidative stress conditions leads to reduced cell viability and RNA degradation, mirroring the phenotypes observed in Rlig1-deficient cells.
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PMC11730311
Schild plots for hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S,N25K-C20DA-γGlu.
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PMC7917457
Statistical analysis was performed with one-way ANOVA.
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PMC9429973
Patients with favorable (cyto-) genetics but high-risk epigenetics might benefit from alternative consolidation treatment strategies, such as allogeneic stem cell transplantation.
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PMC9429973
25 patients (28%) were hospitalized in the ICU.
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PMC11269792
miR-6838-5p inhibitor was transfected alone or si-circAPP and miR-6838-5p inhibitor were co-transfected, (A) Expression changes of miR-6838-5p, (B and C) Colony formation and EdU assays to assess cell proliferation, (D) Flow cytometry to analyze apoptosis, (E) Cellular glucose consumption, lactate production, and ATP levels, (F) ATP/ADP ratio and NAD/NADH ratio, (G) Western blot to evaluate cellular HK2 and PKM2 protein expression; data are expressed as mean ± SD (n = 3). *
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PMC10669128
Interestingly, an established patient-derived orthotopic nude mouse xenograft of a retroperitoneal STS was developed by Hiroshima and colleagues.
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PMC11697189
Fig. 1The characteristics, correlations and differences of heat shock proteins (HSPs) in clear cell renal cell carcinoma (ccRCC). (
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PMC9046263
Differential gene expression (DEG) in each cell line were analyzed for overlapping and neighboring genes at dysregulated HERV loci using the R packages dplyr and Genomic Ranges.
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PMC9275501
Schematic illustration of pH multistage responsive PTX and CUR-loaded PPBV micelles with the PEG detachment and charge-switching function for enhanced cellular uptake and tumor penetration.
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PMC9918897
Newly published studies suggest that even low levels of alcohol consumption increase the risk of mortality, particularly caused by tumors; therefore, this question should not be ignored .
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PMC9611901
Tannins are known to be natural products found in most higher plants.
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PMC9429973
A median intravenous administration of antibiotics was 8 days (range, 0-23).
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PMC11705547
CTLs can reduce the intra-tumoral GSH content by up-regulating γ-glutamyltransferase and promoting IFN-γ secretion from T cells via JAK/STAT1 activation, which sensitizes tumor cells to cisplatin-induced apoptosis .
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PMC11740399
Different concentrations of ML carriers were used to measure the viability of T24 and 5637 cells by CCK8 assay.
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PMC11634027
All of the alleles express Ds:V5 in a proximal-to-distal gradient (Fig. 3D,G, Fig. S4).
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PMC7887261
The cell line was authenticated by ATCC STR analysis and routinely check to be mycoplasma-free.
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PMC11588008
Wash the cells three times with 3 mL of PBS.
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PMC11012012
SLAMF4/CD244 is not expressed by normal B cells.
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PMC8903741
However, a flow cytometry-based approach by detecting and/or separating full-sized antibody-expressing cells can be used to evaluate the transfection efficiency further exactly.
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PMC9844987
While genetic variants associated with gene expression levels (expression quantitative trait loci, eQTLs) frequently occur within gene promoters, they are rarely found associated with housekeeping or ubiquitously expressed genes, and when they are, they have limited effect sizes (Battle et al., 2017).
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PMC7802142
Furthermore, a histological analysis of H&E-stained tissue sections demonstrated that the thickest skin, largest bulb diameter and highest percentage of anagen VI HFs could be found in HFs treated with ReN-NVs, exhibiting that ReN-NVs significantly induced earlier anagen entry and accelerated hair follicle growth compared with control group.
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PMC10965680
Numerous genes were found to be the top signaling genes related to hair follicle and hair growth.
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PMC9429973
Results: The study included 117 recorded cases of Hemophilia (93 A & 24 B).
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PMC9895440
a Scheme representing the principle of the exhaustion model.
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PMC9429973
After four days in culture, we found a 5.5-fold preferential expansion of the CD34CD38CLL-1 cells relative to the CD34CD38CLL-1 cells (P<0.0001).
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PMC11711345
The activity of the cuminaldehyde on HCCL NCI-H520 , as well as on the promisingly proposed NCI-H187 and its role as a CYP2A13 inhibitor, emphasizes the importance of studying it in delivery strategies against lung cancer, as by inhalation.
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PMC11680562
The changes in morphology were seen using a Bright-field microscope .
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PMC11656380
An increased green/red ratio of JC-1 dye indicates membrane depolarization. (
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PMC11471176
This standard inhibitor demonstrated a more potent ACE2 inhibitory effect within a markedly lower concentration range, specifically ranging from 6.25 to 50 nM. The computation of % inhibition for each concentration necessitates the division of the slope derived from the meticulously fitted linear equation characterizing fluorescence across five temporal points for each concentration by the commensurate average slope associated with the enzyme control (DMSO) as delineated in Table 1.Table 1Inhibition kit fluorescence detected at Ex/Em = 320/420 nm for the different time points in Mean ± Standard Deviation with Linear Trendline Slopea and % Inhibition Averageb below.
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PMC11237030
Thus, AQP5 localization is not only limited to the plasma membrane where it exerts its role, but it can be found in the cytoplasm as well.
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PMC6461034
Nodes are depicted as a hexagon (observed kinases, identified through one or more phosphopeptides), a pentagon (inferred kinases lacking direct observation, but linked to phosphorylation of one or more observed phosphopeptides), or as a circle (non‐kinase substrates).
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PMC11670407
e Lentivirus-transfected (shRNA-NC and shRNA-OTULIN) 143B cells were treated with CHX (100 μM) for 8 h and RSL3 (0.5 μM) for the indicated times.
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PMC10975211
This sustained exposure amplifies the cytotoxic effects, resulting in improved efficacy against cancer cells.
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PMC11633763
Stable knockdown of USP22 decreased HK2 expression in osteosarcoma cells. (
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PMC6835428
A transmembrane domain and a tyrosine kinase domain follow the extracellular domain.
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PMC10568263
In the literature, the common methodology and strategy to efficiently enhance signaling are to add nanomaterials, such as metal nanoparticles, conductive carbon materials, conductive polymers, and metal oxides.
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PMC11792888
Normality tests were carried out for all data.
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PMC10812665
The NeuriTox assay endpoint is based on high-content imaging.
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