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Paclitaxel (ptx) is one of the first - line chemotherapeutics used to treat patients with breast, ovarian, nonsmall cell lung cancer, and advanced forms of kaposi s sarcoma . The mechanism involves interfering with the normal breakdown of microtubules during cell division . Successful application of ptx in the clinic h... |
Platinum drugs are a mainstay of cancer therapy . Approximately half of all cancer patients receiving chemotherapy cisplatin, carboplatin, and oxaliplatin (chart 1) three platinum complexes approved by the us fda for the treatment of human cancer are commonly applied to treat bladder, testicular, head and neck, ovarian... |
The ministry of health, labour and welfare of japan has recommended shortening of the length of hospital stays1 . In general, shortening the length of stay contributes to a reduction in the physical and mental stress of patients and rapidly returns them to their jobs and communities . Actually, in a previous study, it ... |
Peritoneal carcinomatosis (pc) is associated with a poor prognosis, and, once it is diagnosed, survival is generally less than 6 months [1, 2]. Peritoneal carcinomatosis represents a devastating form of cancer progression and the pathogenesis of this clinical entity can be explained by several biological models and a b... |
Briefly, poly(-caprolactone) (pcl) were dissolved at 143 mg / ml in equal parts tetrahydrofuran and n, n - dimethylformamide, then extruded at 2.5 ml / h through a spinneret charged to + 13 kv . The resulting nanofibrous jet was collected on a grounded mandrel rotating at 10 m / s and located 20 cm from the spinneret .... |
Cleft lip and palate (clp) is one of the most common craniofacial anomalies of humans . Varied incidence of clp deformity caused due to unknown precise etiology is reported in the literature with severity ranging from minor notching of lip or bifid uvula to complete unilateral or bilateral cleft of the lip and palate .... |
Mammals are the only animals that secrete a complex fluid from an elaborated skin gland to provide both innate protection and nourishment for their newborn . There are more than 4,000 species of mammals with striking similarities in the structure and function of their mammary glands as well as in their unique milk comp... |
When a body part is under pressure, tissue cells do not receive nutrients properly, thereby resulting in their death and the appearance of a lesion . In addition to exposure to pressure, an elevated body temperature and a high skin humidity may also contribute to pressure ulcer formation, which appears as an irritation... |
Tropomyosins (tms) are a family of highly conserved actin binding proteins which are expressed in all eukaryotes from yeast to humans . Tms play a critical role in the control of ca - regulated thin filament function in striated muscle contraction . Except for zebrafish, in vertebrates, there are four known tropomyosin... |
Reduced sperm count and sperm quality are reported from many developed economies and there are also increased rates of testicular cancer manifested in western and northern europe [2, 3], australia, and northern america . It has been suggested that this negative development could be caused by increased exposure to envir... |
Nowadays changing the position of inserted implants is done in individual clinical experiments . In many cases the integrated implants are not in an appropriate position and can cause pressure to the dental nerves, maxillary sinus membrane damage or many difficulties in prosthetic procedure due to incorrect implant dir... |
The introduction of martensitic shape memory (sm) nickel - titanium (niti) alloy in the manufacturing of rotary endodontic instruments has led to relative increase in their flexibility, cutting efficiency and cyclic fatigue resistance . These alloys were popularly termed as m - wire, cm - wire (controlled memory) and t... |
An estimated 10 million us adults have peripheral artery disease (pad), a manifestation of systemic atherosclerosis that has been linked to reduced functional capacity and increased risk of cardiovascular morbidity and mortality . Preventable or treatable risk factors in the initiation and development of pad include ci... |
Multiple myeloma is a malignant neoplasm that is characterized by a monoclonal proliferation of plasma cells . The clinical manifestations of the disease occur as a result of an expanding plasma cell mass in the bone marrow and other factors produced by these cells such as monoclonal immunoglobulin, bence - jones prote... |
Gliomas are the most common primary brain tumors in adults and are usually classified and graded according to the world health organisation (who). Currently, chemotherapy is standard of care for all diffuse gliomas, either at first diagnosis or at first recurrence [15]. Treatment options for patients failing radiothera... |
Chest pain is a typical symptom of acute coronary syndrome (acs), of which there are three common types: unstable angina (ua), st segment elevation (stemi) of myocardial infarction (mi), and non - st - segment elevation of mi (nstemi) [1, 2]. Symptoms of acs in the absence of chest pain are dyspnea, nausea, sweating, n... |
Twenty healthy adults (twelve females and eight males) age 2252 years (average 34 years; without diabetes or known vascular disease) were studied supine or prone in a 7 t system (achieva, philips medical systems, cleveland, oh). Spectra were acquired with a partial - volume quadrature transmit / receive coil customized... |
In canada, fish contribute to over 50% of the dietary intake of mercury (hg) by adults (dabeka et al . 2003), and fish containing the highest concentrations of hg are predatory fish, such as shark, swordfish and tuna (health canada 2007). Hg, present in fish as both methyl - hg and inorganic hg, is a potent neurotoxica... |
Surprisingly, during summer and autumn 2014, sbv reappeared in germany to a greater extent . Several samples from various federal states were submitted to the friedrich - loeffler - institut, federal research institute for animal health (insel riems, germany), to confirm an sbv infection (table) and to further characte... |
Intracranial foreign bodies frequently result from trauma, including penetrating injury, and rarely involve wooden materials compared with metallic materials . When intracranial penetrations of wooden objects occur through the transnasal or transorbital route, physical examinations may reveal no abnormalities, and the ... |
Honey whose medicinal uses date from ancient times has been lately rediscovered as therapy for wounds . The antimicrobial effect of honey has been reported by a number of workers it is commonly used as a base for ointments and has very successfully been applied in surgical dressings for open wounds and burns to avoid s... |
Metastatic spread of tumor cells detached from melanoma into the central nervous system (cns) occurs haematogenically since lymphatic drainage is absent in the brain . The blood - brain barrier is usually intact in metastases that are smaller than 0.25 mm in diameter . The cells from brain metastases show a slower grow... |
The did is a new tool incorporating different functions; it is a carbohydrate / insulin bolus calculator, an information technology device, and a telemedicine system based on the communication between a health care professional (physician or dietitian) and a patient via text messages . It allows patients to manage a fl... |
In recent years, obesity caused by the hypertrophy of white adipose tissue (wat) has steadily increased worldwide, and has become a serious social problem . In 2010, the organization for economic cooperation and development (oecd) released a report on the current state of obesity and the cost - effectiveness of prevent... |
Although endovascular aneurysm repair (evar) of intact infrarenal abdominal aortic aneurysms (aaa) has been associated with a reduction in early mortality and morbidity as compared with open repair, the benefits of an endovascular strategy do not appear to translate to the treatment of ruptured aneurysms . Two randomiz... |
The prevalence of chronic diseases is increasing drastically, and is predicted to increase over the next two decades (1). There is a dramatic re - emergence of old infectious diseases like tuberculosis and cholera, and appearance of new ones, like hiv and hepatitis c (2). Integrated preventive care, rather than treatme... |
Studies found lateral canals in 45% of 74 teeth1 and 27.4% of 1140 teeth observed.2 lateral canals are difficult to instrument and to irrigate during endodontic therapy and may allow bacterial growth.1 although some authors found no correlation between unfilled lateral canals and inflammation of the periodontal ligamen... |
Human immunodeficiency virus (hiv) and acquired immune deficiency syndrome (aids) are associated with multiple endocrine abnormalities . Several investigators have studied the metabolic derangements and reported the functional abnormalities with specific endocrine glands . There is however scant literature regarding hi... |
Castleman disease (cd) is a rare lymphoproliferative disease, which is histopathologically classified into hyaline vascular type, plasma cell type and mixed type . Although the cause of this disorder has not been definitely established, chronic low - grade inflammation, immunodeficiency state and autoimmunity are the p... |
The prevalence of primary open angle glaucoma (poag) is estimated to be between 1.1% and 3% in western populations over the age of 40 years [1, 2]. The estimated number of poag patients in israel is 60,000 . A large survey study including 10,000 israeli participants demonstrated a similar distribution of the disease am... |
The retrorectal space is an uncommon area where tumors occur and these include primary tumors of neurogenic, osteogenic, and congenital origin; in addition to metastatic and inflammatory processes . Congenital lesions include chordomas (remnants of notochord), teratomas, anterior sacral meningoceles, and developmental ... |
In 1983, shafer introduced the term ameloblastic carcinoma to describe ameloblastomas in which there had been histologic malignant transformation . Cases of ameloblastic carcinomas are rare and limited details on prevalence, incidence or relative frequency are presently available . Compared to the metastasizing, malign... |
A host of animal models have been proposed with relevance to modeling the pathological features which characterize alzheimer's disease (ad) brain . In order to test the validity of the animal models, properties and predictions from animal models these features involve a broad spectrum of altered properties from those o... |
The sodium - glucose cotransporter-2 (sglt-2) inhibitors are a novel class of glucose - lowering drugs which act by inhibiting the reabsorption of filtered glucose from the kidneys . This effect is mediated by inhibition of sglt-2 co - transporters, which are expressed in the proximal renal tubule . While their predomi... |
The forensic age estimation of unidentified skeletons and corpses for the purpose of identification has been a conventional feature of forensic science . Determining the identity of a decedent is of considerable significance from the ethical, legal, and criminal perspectives; not only is it the prerequisite for officia... |
The relationship between mind and matter has been a fundamental topic of investigation in many if not all cultures and traditions since the most ancient records of human thought, from the hindu orthodox school of sankhya nearly 27 centuries ago to the classic greek philosophy of plato (e.g., in the dialogue phaedo) 300... |
A human being exposes himself to a variety of injuries caused by numerous forces like vehicular accident, social conflict, terrorism, crimes, wars, industrial accident and fall from a height . The commonly injured organs are the liver, spleen, kidney, intestines, stomach, pancreas, urinary bladder and vessels . Previou... |
For example, storm types have been defined based on the magnitude of the dst index: minor storm (30 nt> dst> 50 nt), moderate storm (50 nt> dst> 100 nt), intense storm (dst <100 nt), and great storm (dst <250 nt) [e.g., gonzalez et al ., 1999]. The dst index is designed to be a measure of the magnetic perturbation near... |
The australian sheep blowfly (lucilia cuprina) is an important ecto - parasite that causes fly strike, which has significant health and welfare, as well as economic, impacts on the sheep industry in australia (sandeman et al ., 2014). The female blowfly is attracted to the sheep by odours, particularly those associated... |
Chromosomal abnormalities affect about 0.5% of living newborns, and are associated with congenital malformation, cognitive defects, learning disabilities, seizures, etc . Cytogenetic techniques can diagnose chromosomal abnormalities, and investigate the possible etiology of birth defects . It is important to know the c... |
Although some recent studies have shown declines in the prevalence of hearing impairment in recent generations,1 2 according to world health organization global estimates, it still represents the most common sensory disorder in the world, with 328 million adults having disabling hearing loss (hearing thresholds above 4... |
The indication for tricuspid valve (tv) surgery is mostly considered at the time of mitral or aortic valve surgery and most often because of tricuspid regurgitation (tr). Concomitant tv repair in this scenario does not significantly increase cross - clamping time and may reduce the morbidity associated with reoperation... |
Methicillin - resistant staphylococcus aureus (mrsa) is recognized as one of the most common pathogens of both nosocomial and community - acquired infections worldwide . As a feature distinct from methicillin - susceptible s. aureus (mssa), mrsa has a transmissible genome element, staphylococcal cassette chromosome mec... |
Chronic obstructive pulmonary disease (copd) is a progressive obstructive airways disease with incomplete improvement in lung function in response to therapy . Copd is estimated to affect 10% of the world s population aged 40 years and its prevalence is expected to continue to increase over the next decade or more.1 an... |
Both vogt - koyanagi - harada (vkh) disease and central serous chorioretinopathy (csc) develop serous retinal detachment, and since recently, it has been well known that in both diseases, the thick choroid can be seen on optical coherence tomography (oct). However, the pathogenesis of each disease is totally different;... |
Chronic liver diseases (cld) and its end - stages, cirrhosis and hepatocellular carcinoma (hcc), are leading causes of morbidity and mortality worldwide with enormous socio - economic costs . Patients with liver cirrhosis are at high risk of deadly hepatic failure and well over 80% of hcc develop on a cirrhotic backgro... |
Ewing sarcoma / primitive neuroectodermal tumor (es / pnet), previously thought to be separate tumors, is now treated as the same tumor; both have similar immunohistochemical characteristics and chromosomal translocation . They are malignant tumors composed of undifferentiated small round cells, usually affecting child... |
T1 dm is an autoimmune - mediated disease characterized by selective destruction of insulin - producing pancreatic -cells, resulting in the need for lifelong administration of exogenous insulin for patient survival, and represents 510% of all cases of diabetes [2, 3]. The pathological condition begins with an autoimmun... |
About 80% of all cancers are diagnosed at ages above 65 years, and up to 75% of cancers are thought to be associated with behavioral factors if modified, they could significantly reduce cancer burden . Analyzing an impact of the modifiable factors on cancer risk, it has been speculated that about 50% of cancers are pot... |
Even though substantial efforts have been made to improve education and public awareness and despite the use of effective medications and life - style changes for controlling the associated risk factors, coronary artery disease (cad) remains the leading cause of death in women worldwide [1, 2]. In contrast to age - mat... |
Dissemination and implantation of gastrointestinal malignancies throughout the peritoneal cavity result in peritoneal carcinomatosis (pc), which is the second most frequent cause of death in colorectal cancer after metastatic disease to the liver . In 25% of colorectal cancer cases, the peritoneal cavity is the only si... |
It has been estimated that there were 7.6 million fatal cases of cancer (13% of all deaths) and around 12.4 million new cancer cases in the year 2008 worldwide . Deaths from cancer are forecasted to continue to grow to over 13.1 million in 2030 . The earlier the cancer is detected, the better the chances of the patient... |
To explore the experiences of patients with cancer who were offered a nurse navigator in their course of illness before the in - hospital period . Development has fragmentized healthcare systems in many countries, and coherence is now desired . Among interventions suggested to reduce the fragmentation and improve deliv... |
Patients with neuropathic pain experience spontaneous tingling sensations, hyperalgesia, and tactile allodynia, symptoms that deteriorate their quality of life . The pathogenesis of neuropathic pain is believed to involve central sensitization of spinal dorsal horn neurons following central or peripheral nervous system... |
Hemophilia a is a congenital disease transmitted by the x chromosome with a recessive trait, characterized by a deficiency in the production of factor viii . The hemophilic pseudotumor affects 12% of patients with a severe disease, frequently associated with a traumatic injury . The hemophilic pseudotumor develops from... |
Approximately, 1.6 million new cases of lung cancer are diagnosed each year throughout the world . Since carcinogenesis is caused by the stepwise accumulation of genetic changes, it is very important to understand the alterations of chromosome and gene in cancer cells . The traditional giemsa banding (g - banding) tech... |
This may cause inconveniences with regard to activities of daily living; thus physiotherapy is often used to treat problems related to joint movement limitation . In previous studies, we have reported the histopathological changes that occur in the rat knee joint components during immobilization; however, the changes h... |
Thalassemia is a genetic disease with an autosomal recessive inheritance pattern in which the generation of one or more hemoglobin chains have been dropped or completely inhibited . Patients with thalassemia major need regular monthly blood transfusions starting at an age of approximately 6 months to maintain oxygen su... |
Actuators, or artificial muscles, based on conducting polymers (cps), and other electrochemically active organic and carbonbased materials, constitute the base for the development of promising polymeric sensing motors, tools for surgeons, or zoomorphic and anthropomorphic soft robots.1, 2, 3, 4, 5, 6, 7, 8, 9, 10 they ... |
Chronic obstructive pulmonary disease (copd) is a frequent cause of hospital admission and a significant burden to health services worldwide . It is predicted that it will be the third likely leading cause of death globally by 2020 . In england, it is estimated that copd affects 3 million people and accounts for 1.4 mi... |
Cardiovascular disease accounted for 30% of an estimated 58 million deaths globally from all causes in 2005 . It is important to recognise that a substantial proportion of these deaths (46%) occurred in individuals under 70 years of age, in their productive years of life; in fact, 79% of the disease burden attributed t... |
Kaposi sarcoma (ks) is characterized by multicentric neoplastic proliferation of vascular endothelial cells . Aids - related ks has a rapidly progressive course with early mucosal and systemic involvement . The incidence of aids - associated ks, especially the disseminated form, is very rare in india . Furthermore, the... |
Based on review of our patient s medical record and current literature, we identified unique commonalities of clinical findings, imaging, and pathology for use in diagnosis and treatment planning . Samples of the patient s stored tissue were analyzed for immunohistochemical evidence of cytogenetic abnormalities . A 14-... |
Triangular fibrocartilage complex (tfcc) injury is one of the most common causes of the ulnar sided wrist pain and distal radioulnar joint (druj) disorder . The ulnar side of the tfcc is divided into three components based on histologic and functional studies: the distal hammock like structure, the proximal ligamentous... |
The dermal vascular changes have been evaluated by electron microscopy and shown to be due to change from arterial - type vessels to venules . The vascular changes may also precede the epidermal alterations, as shown in some studies . Morphometric evaluation of dermal vasculature in psoriasis has shown increased endoth... |
Rape is defined by the world health organization (who) as any sexual act or attempt to obtain sexual act, with unwanted sexual comments or advances against a person s sexuality using coercion (2). Brazilian law defines rape as embarrassing someone through violence or serious threat to have sexual intercourse or to perf... |
Malpositioning of an endotracheal tube (ett) can cause serious complications in airway management and mechanical ventilation . When the ett is inserted deeply, there is a risk of endobronchial intubation, resulting in atelectasis, hypoxemia, and barotrauma . In contrast, an insufficiently inserted ett causes accidental... |
Struma ovarii is an ovarian teratoma, represented in more than 50% by thyroid tissue . Five percent of struma ovarii cases have been proven to be malignant and, as in the thyroid gland, papillary thyroid carcinoma is the most common histotype arising in struma ovarii . Because of the unusual occurrence of this tumor, i... |
We enrolled 1,047 consecutive caucasian patients referred to coronary angiography for the evaluation of stable cad solely on a clinical indication . Coronary angiography was performed as described previously (4); coronary stenoses 50% were considered significant (5,6). The mets was diagnosed according to american heart... |
When i hear the word quantitation, what comes to mind is the contrast between two famous 19th - century german scientists, alexander von humboldt and carl gauss, as described in measuring the world: a novel (kehlmann, 2009). Von humboldt was a great prussian explorer who made many discoveries, including electric eels, ... |
Dementia as one of the major causes of disability and dependence amongst older people is an important aspect of formal service provision within aged care . Dementia is an umbrella term applied to more than one hundred degenerative brain syndromes which include alzheimer disease, vascular dementia, dementia with lewy bo... |
The prevalence rate in the general population ranges between 10% and 12%, making this disease one of the most common causes of pain, activity limitation, and restrictions in participation . Knee osteoarthritis (gonarthrosis) is one of the most frequent forms of degenerative osteoarthritis . In knee osteoarthritis, pain... |
Congenital abnormalities (cas) concern all diseases of organs or body parts developed in utero . They can be either isolated localized in one organ or multiple affecting at least two organs grouped into a syndrome, a sequence, or an association . Their prevalence is about 14% of all human fetuses considering all types ... |
Malignant peripheral nerve sheath tumors (mpnst), which are comprised of 5 to 10% of all soft - tissue sarcoma, often occur in the near proximal extremity at a nerve trunk such as sciatic nerve, brachial plexus, or sacral plexus . They have a distinct association with the neurofibromatosis type 1 and occur in 3 - 15% o... |
Aegypti was maintained in the laboratory of chemical ecology of vector insects of the federal university of minas gerais from 2007 . The breeding room was kept at a temperature of 27 1c, 75 - 80% relative humidity (rh) and a 12l:12d photoperiod (eiras & jepson 1991). The larvae were kept in plastic tubs containing wate... |
The increase in the aged population, a westernized lifestyle, the development of diagnostic tools, and national surveillance programs for early prostate cancer detection may all have contributed to the increased detection rate of prostate cancer . Checking the serum prostate - specific antigen (psa) level and a digital... |
In aging males, benign prostatic hyperplasia (bph) is one of the most common and bothersome diseases influencing quality of life . For decades, transurethral resection of the prostate (turp) has been recognized as the standard treatment for bph . In recent years, laser treatment of bph has challenged turp as the result... |
All the solvents and chemicals were purchased from merck, nice chemicals and sd fine chemicals . Melting points were determined by using melting point apparatus mp - ds tid 2000 v and the values were uncorrected . Reactions were monitored by thin layer chromatography (tlc methanol: acetone, 6: 4) on pre - coated silica... |
Peripancreatic fluid collections (pfcs) can develop secondary to either fluid leakage or liquefaction of pancreatic necrosis following acute pancreatitis, chronic pancreatitis, surgery, or abdominal trauma.14 previously focusing on the original atlanta classification of acute pancreatitis,5 pfcs include acute fluid col... |
Scientists have recognized communication between the brain and the gut for more than 100 years, with studies in the early 19th and 20th centuries showing that a person s emotional state can alter the function of the gastrointestinal (gi) tract.13 one of the best examples is the work of william beaumont, an army surgeon... |
Pulmonary adenocarcinoma is a common malignancy that is prone to calcification, although bone formation in primary lung adenocarcinoma is extremely rare . Heterotopic ossification in primary lung adenocarcinoma was first described by mclendon et al . In 1985 (1). To our knowledge, however, only 11 cases of pulmonary ad... |
The classification of orbital tumors is very difficult because tissues of various origins and structures are present in this region [13]. The most frequently used classification divides tumors into various categories, including: primary tumors deriving from the orbital tissues, intraocular, corneal, conjunctival tumors... |
There are many challenges in reproductive health and it is necessary to train experts to manage them . The aim of this study was to define the tasks of master of science (msc) graduates in reproductive health through comprehensive needs assessment to establish the course . The study comprised of three steps . In the fi... |
Continuous care delivery demands that health care providers lead patients smoothly through a chain of care that includes a number of professionals, departments and organizations, each of which are necessary for the provision of quality care at the right time and in the right place for each and every patient [15]. Exper... |
This review focuses on advances in analytical technologies for high - throughput (htp) glycomics (i.e. The large - scale study of glycoconjugate glycosylation patterns). Our emphasis will be on glycomics to support (1) realization of glycoprotein biopharmaceuticals and (2) development of glycan biomarkers of disease fo... |
A 62-year - old man (height, 158 cm; weight, 63 kg; blood type, a) with a history of smoking (35 pack - years) was registered for lung transplantation with a diagnosis of idiopathic pulmonary fibrosis . The patient s status was new york heart association functional class iii, and the patient had lost 5 kg over a 6-mont... |
X - linked dominant chondrodysplasia punctata (cdpx2, omim 302960) is an inheritable systemic disease and is characterized by skeletal, ophthalmologic, and cutaneous manifestations . In the late seventies, rudolph happle reported a female and brilliantly recognized a group of published patients with chondrodysplasia pu... |
Although in most cases (8090%) the ingested foreign body will pass uneventfully through the gastrointestinal tract, sharp foreign bodies such as toothpicks are associated with an increased risk of gastrointestinal perforation and bleeding . The most common causes of the accidental ingestion of toothpicks include alcoho... |
The q - switched nd: yag laser may cause photodisruption at the injury site, which occasionally results in a macular hole . Described 5 eyes of 4 patients with macular holes caused by accidental q - switched nd: yag laser injury . In 1 of these eyes, the macular hole resolved spontaneously . Long - term delayed surgery... |
Ectopic gastric mucosa and polyps related to brunner's gland hyperplasia are the most common polyps . Serrated polyps are characterized by infolding of the crypt epithelium, resulting in a saw - tooth appearance . A polyp with serrated morphological features has been classified histologically as hyperplastic polyp in t... |
A 16-year - old, castrated male, feline immunodeficiency virus (fiv)-positive, domestic shorthair cat developed multiple skin lesions . Most of these were bowenoid carcinoma in situ and contained dna sequences consistent with felis catus papillomavirus type 2 . Two additional lesions that developed in the skin and subc... |
A 32-year - old healthy caucasian lady presented complaining of recent deterioration of vision in her left eye . At presentation, her best corrected visual acuity (bcva) was 20/20 in her right eye and counting fingers in her left eye (le). Fundus examination and fluorescein angiography revealed findings consistent with... |
Receptor tyrosine kinases (rtks) are a class of protein kinases that play a critical role in the development and progression of various types of cancer . Recently, approximately 20 different rtk classes have been identified, with axl belonging to one of these classes . The axl receptor tyrosine kinase was isolated as a... |
Data was provided by a larger, ongoing, longitudinal study of rape victims who presented at a center for rape victims (crv) at the university hospital, aarhus, denmark . Four hundred and eighty - four participants were administered the asds between two and three weeks post - rape . However, eight cases were missing> 20... |
Gierke, in 1905, described a lesion of adrenal gland containing fat and myeloid elements . A 40-year - old man referred to department of endocrinology with adrenal mass and hypertension . He was diagnosed with hypertension 3 years back, initial bp was 180/110 mm hg, was started on anti - hypertensive treatment . On exa... |
Diabetes mellitus is a chronic metabolic disorder that is distinguished by hyperglycemia, underutilization of blood glucose, and defects in the metabolism of macronutrients such as carbohydrates, fat, and protein, secondary to the disturbance in insulin action [1, 2]. Type 1 diabetes is caused as a result of insulin de... |
Male homozygous db / db and age- or sex - matched heterozygous littermates db/+ were obtained from the jackson laboratory (bar harbor, mi). Male balb / c mice were purchased from charles river laboratories (wilmington, ma). Mice were housed in standard shoebox cages supplied with standard rat diet and water ad libitum ... |
They are known to become symptomatic as a consequence of enlargement, infection, or rupture, the latter being an exceedingly rare complication traditionally treated with open splenectomy . We herein report a unique case of a giant epidermoid splenic cyst that ruptured spontaneously and was successfully treated with the... |
The nshd is a socially stratified birth cohort of 2547 men and 2815 women of white european descent born during 1 wk in 1946 who have been followed with repeated data collections since then (14). Between 2006 and 2010, at 6064 yr, contact was made with 2661 (84%) of 3164 eligible study members still alive and living in... |
Peptide amphiphiles are a fascinating class of bioactive molecules in which one or more lipid chains are attached to peptides, either bioderived, bioinspired, or designed . The lipid chains drive self - assembly, leading to nanostructures in which the functional peptide unit can be presented at high density, for exampl... |
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