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The changes of gene expression level after estrogen stimulation could be the result of hormone receptor interaction via estrogen response elements (eres), activation of the target gene transcription through interaction with co - activators or over non - genomic pathways (1,2). A number of genes whose transcription is a... |
In a recent issue of critical care, brandt and coworkers performed fluid resuscitation on pigs with endotoxemia or fecal peritonitis using either moderate volumes of crystalloids (103 ml / kg / h) or larger volumes of crystalloids supplemented by 130/0.4 hydroxyethyl starch (combined 203 ml / kg / h). These protocols w... |
Cystatin c is a nonglycosylated, low molecular weight (13.250 da), basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors [13]. It consists of 120 amino acids, it is produced by all nucleated cells at a constant rate, and it is excreted by the kidneys by free glomerular filtration an... |
In the previous issue of critical care, huang and colleagues try to answer the unresolved question of the prognostic value of sepsis - related cardiomyopathy . Since margaret parker and colleagues originally reported in 1984 that 65% of patients had significant left ventricular (lv) systolic dysfunction in the early ph... |
Type 2 diabetes mellitus causes excessive morbidity and premature cardiovascular (cv) mortality . Although studies have documented the benefits of optimal glycemic control on microvascular complications, the effect of tight glycemic control on macrovascular complications is unclear . In the action to control cardiovasc... |
The purpose of the danish database for cervical cancer screening is to provide an annual status for the nationwide screening program and to document the screening quality over time by monitoring nine quality indicators . The first annual report covered the activities in 2009 and the latest report covered the activities... |
Friction and resistance to sliding (rs) are topics that have been well studied within the orthodontic literature . Kusy and whitley define rs as a combination of classical friction, binding or notching depending on the contact angle . In terms of this research terminology, classical friction is defined as the friction ... |
With the rise in the prevalence of obesity, the field of bariatric surgery is witnessing an ever increasing demand . Along with that, comes the challenge of operating on patients with high body mass index (bmi), revisional bariatric procedures (rbp), managing complications and reoperative abdomens . Performing bariatri... |
Ectopic molar pregnancy is a rare occurrence and consequently not often considered as a diagnostic possibility . In this article, an attempt was made to stress on the need for histopathological examination and follow up of every case of ectopic pregnancy . A 30-year - old gravida 4, para 3, pregnant woman with a 7-week... |
Bd is a multisystemic disease that may affect any organ in different combinations? Characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions . Involvement of the heart is called cardio - bd, which includes pericarditis, myocarditis, endocarditis, endomyocardial fibrosis, atrial fibrilla... |
Dendrimers provide an alternative and potent means for drug delivery due to their nanometer size and the ability to incorporate various functionalities on their interior and exterior . Modern chemical synthesis capabilities allow various functionalities to be incorporated on the dendrimer exterior in order to optimize ... |
Hepatocellular carcinoma (hcc) is the second most common cause of cancer - related death worldwide . With the exception of japan, hcc in asian countries most often occurs in patients with underlying chronic hepatitis b virus (hbv) infection through a multistep process of hepatocarcinogenesis . With the development of d... |
The study was approved by the ethical committee of the hospital district of southwestern finland . Fourteen patients with relapsing - remitting ms (10 women) initiating natalizumab treatment (tysabri, 300 mg iv every 4 weeks; biogen idec, cambridge, ma) at the neurology outpatient clinic of the division of clinical neu... |
The global population growth is estimated to increase from 6.8 million today to 8 billion by 2025, which will put pressure on water demand from many perspectives as water is used in the production of both food and energy (4). More people demand more food and also, with a shift in diet to more so - called westernised fo... |
Accessory and cavitated uterine mass (acum) is a rare, newly recognized mullerian anomaly . It is an accessory cavity lined by functional endometrium within an otherwise normal uterine cavity, in contrast to the other mullerian anomalies in which the uterus is malformed . The cavitated mass is locally defined to myomet... |
Multiple sclerosis (ms) is a chronic neurological disease that affects brain and spinal cord . It is estimated that women are affected three times more than men (1). Ms damages the myelin sheath involving the white matters of central nervous system . Tentorial incisure (also known as the tentorial notch or incisura ten... |
Since 1984, in an attempt to maintain at least part of the splenic function when the removal of the spleen is recommended, we have performed subtotal splenectomies, preserving the superior splenic pole supplied by the splenogastric vessels . This procedure was successfully used for the treatment of 130 patients with po... |
These may occur at any site along the gastrointestinal (gi) lumen including rectum, duodenum, small and the large intestine, but are also reported outside the gi lumen, in the retroperitoneum, abdominal wall, along the gall bladder wall, etc . In a nationwide survey of ectopic varices in japan, duodenal varices (dv) we... |
Trimethoprim (tmp)/sulfamethoxazole (smx) is a broad - spectrum antimicrobial combination effective in treating a variety of microorganisms and has been used in clinical practice for more than 50 years . High response rates demonstrated in clinical studies support tmp / smx as the drug of choice for serious infections ... |
Pegaptanib was developed in the 1990s using the selex (selective evolution of ligands by exponential enrichment) technique . The result was a 29-nucleotide aptamer, with a chemically modified rna backbone that increases nuclease resistance and a 5 terminus that includes a 40kd polyethylene glycol moiety for prolonged t... |
Over the last decades, obesity has become a global epidemic and an important public health problem in many countries . This condition is largely due to excessive consumption of saturated fats and simple sugars [2, 3], which, associated with sedentarism, represent the modern lifestyle . Obesity is recognized as a risk f... |
Alzheimer's disease (ad) is the most common form of dementia, characterized by progressive cognitive impairment, cerebral atrophy, and neuronal loss, with death generally occurring four to eight years after diagnosis . Two pathological hallmarks of ad, extracellular neuritic plaques primarily composed of amyloid beta (... |
A large percentage of individuals (28%34%) with alzheimer s disease (ad) live alone in their own homes,1,2 and it is reasonable to assume that the number of solitary - living elderly individuals with dementia will increase in the future . The longer life expectancy of humans implies the rise of ad prevalence rates.3 in... |
Paragangliomas (pgls) are uncommon tumors (incidence 1 - 2 per 100,000) and based on their locations, the tumors are often given special designations . Only three percent (3%) of all pgls occur within the head and neck of which the majority are located in the carotid body (carotid body tumors), temporal - bone / middle... |
The most common fracture of the orbital wall in the pediatric age group is involvement of floor . Possibly, because of the greater elasticity of the orbital bones in the pediatric population, they are more prone to fracture with less force of injury . Many studies have indicated that early diagnosis and surgical repair... |
The ability of lasers to induce hair growth was incidentally noted as early as 1967 when mester et al . Used low - level laser therapy (lllt) to treat cancer in mice with shaved backs . Since then, hypertrichosis has been recognized to be a possible side - effect of laser treatment . First described in 2002 with intens... |
Emblica officinalis fruits were purchased from the local market and authenticated by our faculty taxonomist dr . A. s. reddy, and voucher specimen was retained in the departmental herbarium (rav #01). The pulp was extracted, air dried, ground to powder and stored in an air tight container . A quantitative phytochemical... |
Flax is a food and fiber crop that is grown in some regions of the world . Its value will account for its great popularity as a food, medical and cosmetic applications . Flax fibers are taken from the stem of the plant and are two to three times as strong as cotton . In this study, we compared brain weight and plasma s... |
General anaesthesia was achieved by an intraperitoneal injection of 0.1% xylazine (13 mg / kg) and 0.1% ketamine (87 mg / kg). A midcrestal incision was made on the maxillary alveolar ridge in the existing edentulous area between the 1st molar and the incisors . A fullthickness flap was raised on each side of the incis... |
Patients with cleft palate often exhibit nasality, which is a distinctive feature and an important target in speech therapy and rehabilitation . To evaluate velopharyngeal function, the aerodynamic and acoustic aspects of nasalization have been studied . An aerodynamic exam can diagnose the degree of velopharyngeal clo... |
Recurrence of c. difficile was defined as confirmed presence of c. difficile toxin via polymerase chain reaction (pcr) after complete resolution of diarrhea for a minimum of 2 weeks and a maximum of 6 months and the completion of antibiotic therapy (5, 7). Rf is a statistical model used for classification and regressio... |
Xylanases are enzymes that catalyze the hydrolysis of 1,4--d xylosidic linkages in xylan, the second most abundant polysaccharide in nature after cellulose, and the most abundant hemicellulose in plant cell walls [1, 2]. There has been a resurgence in interest in microbial xylanases due to their numerous uses in indust... |
However, the actual incidence may be higher because many victims may die before arrival at the hospital . With advances in traumatology, several studies have investigated the prognostic factors associated with traumatic cardiac rupture . In this study, we attempted to find factors affecting the prognosis of patients wi... |
Tumor vascularization, vital to neoplastic progression, provides nutrients and oxygen to the tumor [13]. Proliferation of vessel - forming endothelial cells is a limiting factor for tumor growth [47]. Accordingly, targeting tumor vessel proliferation decreases blood flow and nutrient availability, thus slowing tumor gr... |
Serotonin transporter gene (slc6a4, solute carrier family 6, member 4) encodes an integral plasma membrane protein that plays a major role in the regulation of serotonin neurotransmission (1). It has been widely recognized as the target sites of selective serotonin reuptake inhibitor (ssris), which have been recognized... |
Researchers worldwide have embraced the fact that graphene, a two - dimensional sp hybrid of carbon atoms with a honeycomb structure, is without doubt an extraordinary substance that has been extensively investigated either on its own13 or as a composite material.4,5 the intriguing mechanical, thermal, electrical, and ... |
Embryonic development involves spatial and temporal patterns of cellular differentiation and the shaping of form . How do embryonic tissues organize in space and time such that a field of distinct cells emerges reliably? This question has fascinated developmental biologists for decades . Early in the last century, the ... |
The western denmark heart registry (wdhr) is a clinical database within a population - based health care system . To improve cardiac treatment quality, the danish national board of health decided in 1993 to increase the number of invasive cardiac interventions in denmark.1 in response to this initiative, the wdhr was f... |
Ameloblastic fibro - odontoma (afo) is defined as a benign odontogenic tumor with slow growing behavior . Afo is characterized by histologic features of ameloblastic fibroma (af) with the formation of enamel and dentine . This is a case report of afo accompanied with a number of impacted deciduous teeth and its managem... |
This could be partly because of the racial predilection as a large percentage of the population has curly hair and also may be due to local cultural customs which unlike the west do not encourage daily shaving of facial hair . Twenty - four consecutive male patients presenting to a university health center over a 1 yea... |
Superficial fungal infection is a global problem with an estimated 20 - 25% of the world's population having cutaneous mycoses . It is also noteworthy that the prevalence of a particular mycosis is influenced by local socioeconomic conditions and cultural practices . Thus, the choice of therapy at times is guided by th... |
We examined hiv - positive injection drug users from manipur who had been identified as anti - hbc positive during previous serosurveys conducted by the national institute of cholera and enteric diseases (2). Serum samples (stored at 80c) taken from 63 men 1825 years of age were available for the study . Hbsag detectio... |
. However, several precorneal factors such as lacrimal secretion (tear turn over and reflux tearing), tear protein binding, ph, shorter contact time, and other corneal constraints limit drug penetration . Moreover, presence of various uptake and efflux transporters in cornea also reposted to further complicate the ocul... |
Vertical transmission of human immunodeficiency virus (hiv) is still a major challenge in the world, especially in developing countries . A report in 2012 reported about 35.3 million people are living with hiv of which 2.3 million are new infections whereas an estimated 3.3 million infected people are less than 15 year... |
Rotaviral diarrhea (rd) is the most common cause of gastroenteritis in children (1, 2). Almost all children younger than 5 years old will have suffered from rd, with> 500,000 deaths,> 2 million hospitalizations, and> 25 million clinic visits each year (3, 4). The rotavirus can infect the intestinal epithelium villi cel... |
According to who report, osteoporosis is one of the top 10 global diseases of 21 century attributed by an altered bone turnover rate due to impaired activity of osteoblast and over activity of osteoclast . Antiresorptive and bone forming drugs are two foremost choices available for the treatment of osteoporosis . Most ... |
For analyses of allele frequency differentiation across populations and allele frequency distributions, we used subsets of snps from hapmap (public release #21a) which were ascertained uniformly across the genome so that the data sets are appropriate for population genetic analysis8 . All the snps in our study are ther... |
Irritable bowel syndrome (ibs) is a functional disease with persisting gastrointestinal symptoms, mainly abdominal pain / discomfort and abnormal defecation, not accompanied by an organic disease.1 the cause of ibs is unknown, but a number of factors are thought to play a role, such as altered gastrointestinal motility... |
However, this is not a new disease and it was clinically described and treated for the first time by rhazes (865 - 925 ce). The disease was also mentioned in the canon of medicine by avicenna (9801037). We searched in scopus, web of science, and pubmed for allergic rhinitis, interactions, non - prescription, prescripti... |
Pagetoid reticulosis (pr) is an uncommon disease clinically characterized by the presence of solitary, psoriasiform, slowly growing cutaneous plaques located on the extremities and, at histological level, by a characteristic dense inflammatory infiltrate with pagetoid spread within the dermis and the upper dermis compo... |
An appendiceal origin of the lower gastrointestinal bleeding (lgib) is extremely rare.1 to obtain its proper diagnosis, though a various diagnostic modalities have been approached, like angiography,2 radionuclide scintigraphy,3 multi - detector computed tomography (mdct),4 or colonoscopy, it is still difficult to make ... |
Various decisions are made on using technology at all levels of the health system in every country which usually include coordinating complicated medical issues with matters related to patients, organizational, economic and moral factors . Also, providing appropriate inputs for health policy- makers which depend on int... |
Seborrheic keratosis (sk) is common benign epidermal proliferation, which can occur anywhere in the skin the exception of palms, soles, and mucosa (there was only one report of mucosal sk in the conjunctiva). Sk involving the genital region is a rare entity, which can be easily misdiagnosed as genital warts . Recently,... |
In recent years, near - infrared spectroscopy (nirs) is increasingly used to monitor regional cerebral oxygen saturation (rso2) during cardiac surgery . In fact, neurologic injury is still a common complication after cardiac surgery, with rates of postoperative neurocognitive decline (poncd) and stroke of up to 50% and... |
The first glimpse of the ctd structure was through its interaction with human pin1, a unique prolyl isomerase that catalyzes cis / trans isomerization of specific phos.ser/thr-pro motifs in signaling proteins (1316). Identification and characterization of this novel peptidyl - prolyl cis / trans isomerase (ppiase), pin... |
Pulp necrosis and interruption of tooth development, which result in incompletely formed roots with wide open apices, reduced root length, and fragile thin dentinal walls, may be the consequences of physical trauma or endodontic infection of a tooth with an immature apex . Apexification is a treatment used to seal an o... |
O2 battery has been widely investigated because of its extremely high theoretical energy density amounting to 3500 wh / kg for the overall battery reaction . In the past 10 years, significant progress has been realized in understanding the complex chemistry that governs the functioning of this battery system . This has... |
Among the elderly, the prevalence of anxiety and mood disorders is fairly significant . In qubec, canada, 12% of seniors exhibit symptoms of this type.1 in france, in any given month, the prevalence of depression and anxiety in older individuals varies from 8% to 11%.2 older persons affected by a mental disorder freque... |
Systemic lupus erythematosus (sle) is a chronic systemic autoimmune disease that is caused by the loss of tolerance to one s own antigens and the production of autoantibodies forming immune complexes that are deposited in various organs, which induces an inflammatory response . Sle development is triggered by genetic, ... |
Measurement of the outcome is critical for any decision - making and results of evaluations in all medical circumstances . The japan orthopaedic association (joa) developed and published a specific instrument to measure outcomes for patients with low back problems in 1986.1 it was called the joa score rating system for... |
They are characterized by the presence of the following (1) hydrazone schiff bases of acyl, aroyl, and heteroaroyl compounds have an addition donor sites like c = o . This versatility has made hydrazones good polydentate chelating agents that can form a variety of complexes with various transition and inner transition ... |
Silent lacunar infarction (sli) has commonly been regarded as a benign subtype of stroke, associated with relatively mild disability . Most previous studies reported a close link between fresh infarcts and post - stroke depression (psd). Psd is defined as depression occurring in the context of a clinically apparent str... |
Expectations of scientific research run high . Internationally, funding bodies and government agencies have placed increasing emphasis on the outcomes and impact of scientific endeavour (campbell et al . The promise of science lies in expectations of the benefits bioscience can bring to societies and is matched by expe... |
Hypotension is a known effect of atypical antipsychotics . In addition, the prevalence of orthostatic hypotension in the elderly is estimated to be between 5% and 33% and increases with age.1 orthostatic hypotension is a common side effect of a number of medications, including antipsychotic drugs, and a major contribut... |
More than 60 diseases and injuries resulting in approximately 2.5 million deaths per year worldwide are linked to heavy alcohol drinking (edwards et al ., 2011). The number of current available medications for the treatment of alcohol dependence is limited, and most treatments show only moderate efficacy . Promising re... |
Cerebrospinal fluid is a functional system closely connected to the brain, and changes or variations in the csf may mean an alteration in the brain expressed by encephalic disorders . However, the composition of csf may also be altered by systemic diseases, such as arterial hypertension, and cerebral ventricular dilata... |
Sleep disorders are increasingly recognized as important factors in glucose metabolism and the development of type 2 diabetes . Sleep - disordered breathing (sdb), a condition characterized by a reduction or complete cessation of airflow during sleep, has repeatedly been linked to impaired glucose tolerance and insulin... |
A 64yearold woman presented with 68 sharply demarcated, darkly pigmented macules around the anus (fig . 1) and a 3month history of intermittent rectal bleeding . The patient underwent a colonoscopy and an ulcerated 3.6 cm in diameter, polypoid, pigmented tumor of the anorectal verge was found (fig . Based on the patien... |
Two recent national advisory committees on social security recommend major shifts in medicare financing to preserve the financial viability of the social security trust funds . This paper estimates the income redistribution consequences of the two proposals, concentrating especially on the often - ignored financing bur... |
The prosthetic rehabilitation for maxillectomy patients aims at separation of oral and nasal cavities to allow adequate deglutition and articulation, to restore the midfacial contour and to provide acceptable esthetic results . Lack of support, retention and stability are common problems associated with patients who ha... |
The incidence of central venous catheter (cvc) malpositions ranges from 3.6 to 14% . Ultrasound has reduced some of the complications during its insertion, but cannot locate the catheter tip in relation to heart . Only transesophageal echocardiography can accurately detect a cvc tip in relation to superior vena cava (s... |
At the first medical examination, the sister was 7 years 8 months old, and the brother was 5 years 3 months old . Neither sibling had any specific birth history . Slit lamp microscopic examination revealed no abnormalities in the anterior segments of either eye, in either patient . The best corrected visual acuities (b... |
Slipped capital femoral epiphysis (scfe) is a common hip disorder in adolescents, characterized by medial and posterior displacement of the proximal femoral epiphysis on the metaphysis . In contrast, some hips may slip in a posterolateral displacement, producing an apparent valgus deformity and a so - called valgus scf... |
Chemokines (cks) are low molecular weight chemoattractant peptides, belonging to the cytokine family . Differently from interleukins, cks act via g protein - coupled receptors (gpcrs), controlling cell migration and trafficking throughout the body, during immune response and development [3, 4]. Cks are also critical me... |
Microbial fermentation ensures production of industrially important metabolites in large quantities . Implication of rdna technology in microbial fermentations offers production of desired heterologous proteins at large scale . Apart from the proteins, nature offers diverse classes of complex metabolites (isoprenoids) ... |
The annual costs of major depressive disorder (mdd) are estimated at 83.1 billion dollars in the united states, with nearly two thirds of this cost arising from functional disability . The costs of mdd are high in part because it takes so long for patients to recover from the illness . Current treatment guidelines reco... |
Based on the results of molecular phylogenetic analysis, the mucorales, the core group of the traditional zygomycota, have been reclassified into the subphylum mucoromycotina of the new division, glomeromycota (1). These fungi are ubiquitous saprophytes that are scattered widely in nature, food, soil, and air (2). The ... |
To date, most allosteric drugs have been discovered through high - throughput screening . But growing databases of biomolecular structure and sequence data, in conjunction with increases in computing power and improvements in predictive algorithms, are enabling the rational de novo design of allosteric drugs . Given th... |
To create the building blocks that make up the synthetic promoters oligonucleotide pairs, each with a 5 phosphate, were annealed by being boiled and then slowly cooled to room temperature (see supplementary information for building block sequences). 15 l of 50 m double stranded building blocks were then ligated with 20... |
Mast cells are the key effector cell of the biological response to anaphylaxis with the release of various mediators of inflammation . The frequency of anaphylaxis is approximately 502000 episodes/100,000 persons and has a lifetime prevalence of 0.052.0% . Recent studies have shown that there is an increase in incidenc... |
The presentations at the session demonstrated that current species recognition in lichen forming - fungi vastly underestimates the true number of species . Based on phylogenetic and population studies, many cases were presented showing that numerous distinct lineages are hidden under a single species name . The issues ... |
A range of ii - vi semiconductor nanoheterostructures has been synthesized, including spherical core - shell particles, seeded nanorods, and seeded tetrapods . These heterostructures allow for sophisticated manipulation of photons and carriers at the nanoscale and exhibit many interesting phenomena, including extremely... |
The smile design theory can be broken down into four parts: facial esthetics, gingival esthetics, microesthetics and macroesthetics . Gingival esthetics involves health of the gingiva, shape of the interdental papilla and the presence or absence of black triangles . Microesthetic features involve the anatomy of the ant... |
According to the korean society for the study of obesity, about 30% of the korean population is classified as overweight or obese, which has been linked to the development of various malignant diseases, including colorectal cancer and breast cancer . According to data from the korea central cancer registry in 2008, the... |
In being responsible for about 350,000 new cases and 150,000 deaths yearly in france, cancer is a major health problem and its surveillance the utmost public health concern . Regarding surveillance, francim, the french network of cancer registries, is responsible for exhaustive collections of cancer cases in 10 to 14 f... |
The most common manifestation of primary epstein - barr virus (ebv) infection is acute infectious mononucleosis, a self - limited clinical syndrome that most frequently affects adolescents and young adults . Serology is one of the cardinal means of diagnosing ebv infection as antibody search for viral capsid antigen (v... |
Excessive accumulation of fat in the liver, that is, intrahepatic triglyceride (ihtg), is associated with increased prevalence rates of and risk for dyslipidemia, diabetes, and cardiovascular disease [13]. Data from epidemiological as well as metabolic studies indicate that increased ihtg content is accompanied by insu... |
The number of flies transported by means of ventilation air into a broiler house in denmark was counted from july 22, 2003, to july 28, 2003, and the campylobacter carriage rate of flies captured in the environment of the broiler house was estimated . The study period was chosen because flies generally peak in activity... |
Female nod / ltj and bdc2.5-nod, wild - type c57bl/6, h-2 c57bl/6, and mhc ii c57bl/6 were purchased from the jackson laboratory (bar harbor, me). All mice were maintained in a pathogen - free room at city of hope research animal facilities (duarte, ca). Flow cytometry staining and analysis, cd11c enrichment, and cd4 t... |
-stacking in radical dimers, some of which are illustrated in chart 1 in the form of the constituent monomers, is responsible for the formation of a very interesting class of chemical compounds which display favored packing geometries as described by the maximum multicenter overlap principle between neighboring molecul... |
West nile virus (wnv) is not restricted by international borders and involves all continents, revealing adaptation of the virus with different ecological zones . Mosquitoes and birds, as vector and reservoir respectively, play an important role in the virus circulation . Several studies have defined the potential impor... |
Hemizygous and homozygous deletions on the long arm of chromosome 13 are the most common genetic aberrations in b - cell chronic lymphocytic leukemia (cll) and monoclonal b - cell lymphocytosis (mbl), occurring in approximately 50 percent of cases . The reported deletions are usually large and heterogeneous in size and... |
Neonatal hypoxic - ischemic encephalopathy (nhie) is a neurologic disorder that can cause disturbances in global development of children.1 2 it is the most prevalent neurologic disorder in the neonatal period, and the deleterious effects of hypoxia and ischemia can affect the central nervous system of newborns.1 3 4 th... |
Mosquitoes were sampled in rural areas interspersed with fragments of secondary forest at agronomy center for the vale do ribeira (fig . 1). Three localities equidistant by 1 km were selected to install one mmi, one cdc with co 2 and lurex3 [cdc with co 2 and lactic acid (cdc - a)] and one cdc - lt . Mosquito collectio... |
In herpes simplex encephalitis (hse), the gray matter of the temporal and frontal lobes is predominantly destroyed by many foci of hemorrhage and necrosis . The lesions usually begin either unilaterally or bilaterally in the medial temporal cortex with bilateral spread along limbic pathways to the orbital frontal lobe ... |
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