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A lump in the salivary gland region often presents as a diagnostic challenge with regards to its site of origin, benign or malignant . Most of these occur in the parotid glands; small percentages occur in the submandibular, sublingual, and minor salivary glands . Are a histologically diverse group . Tumors of this regi... |
Variceal bleeding is the most common lethal complication of cirrhosis, with a mortality rate of 20% . Gastroesophageal varices (govs) are present in 50% of cirrhotics, and approximately 25% of patients with portal hypertension have gastric varices . Gastric varices are commonly classified as govs (gastric varices in co... |
Health economics is a branch of economics that studies and evaluates the quantity, quality, and value of the limited resources available to healthcare systems, as well as determining how these factors best combine to produce certain services, with the aim of maximizing effectiveness and efficiency . Us health costs are... |
The construction of long dna oligonucleotides, such as synthetic genes, is useful for a number of reasons . For protein expression, it is possible to improve the yield of a desired protein by optimizing codon usage to reflect the relative codon abundance in the host organism used for protein production . Long oligodeox... |
Pilonidal sinus is a well recognized chronic inflammatory condition which affects the natal cleft, finger web space, and it is rare in the penis . We report on a case of penile pilonidal sinus in a 24-year - old man who has severe mental illness, autism, and developmental delay . The literature was reviewed and there w... |
Three different types of aiha can be studied based on the behavior of the autoantibodies involved in the pathogenesis:1 (1) warm aiha, which is most commonly mediated through igg autoantiobodies (polygenic; commonly against the antigens of rh system) that are most potent at temperatures 37 c, (2) cold aiha, which is ge... |
Participants came from the twins early development study (teds), a population - based longitudinal study of all twins born in england and wales from 1994 to 1996 . The present paper is based on data collected from parents when the twins were approximately 8 (mean sd = 7.89 0.53), 9 (9.01 0.29), and 12 (11.28 0.70) year... |
Tum or consisted of a firm, well - circumscribed, ovoid piece of soft pink tissue measuring 21.51 cm in the supraglottic area of the larynx . Histologically, the mass showed a fibrous and chondromyxoid stroma containing epithelial and myoepithelial cells . Epithelial component consisted of relatively uniform - appearin... |
Secondary hyperparathyroidism (shpt) is often underdiagnosed or insufficiently treated in patients not yet receiving dialysis, when therapy would have greater short- and long - term benefits . Hyperparathyroidism also frequently persists after successful renal transplantation and is present in up to 50% of patients 1 y... |
P. vivax is the most prevalent cause of human malaria in the americas, accounting for more than 70% of total cases reported . Chloroquine (cq) at a dose of 25 mg / kg over three days remains the first line therapy for vivax malaria . To prevent relapse, pq is given to all nonpregnant patients greater than 6 months of a... |
Vibrio parahaemolyticus and vibrio vulnificus are important foodborne pathogens associated with the consumption of fish and shellfish, especially oysters, which have long been known to bioconcentrate vibrios within their edible tissues [1, 2]. Vibrio vulnificus also causes life - threatening illness from wound infectio... |
The millennium cohort is the largest prospective study using primary data collection ever undertaken by the department of defense (dod). The study began in 2001 with the objective to collect and evaluate data on health, behavioral risk factors, and occupational characteristics related to military service that may be as... |
Pathologically, ad is characterized by extracellular aggregation of amyloid - beta into senile plaques and hyper - phosphorylated tau protein accumulation in intraneuronal neurofibrillary tangles (beach et al ., clinically, ad is characterized by progressive cognitive decline that typically presents with memory loss as... |
Herbal ingredients are commonly found in many products, including cosmetics, drugs, foods, and oral hygiene products, such as mouth rinse, toothpaste, and lozenges . For example, the biological properties of herbal substances should be evaluated to exclude the possibility of adverse effects on human tissue . The toxic ... |
The introduction of modern surgical techniques including phacoemulsification and small incision cataract surgery has contributed to a reduction in the incidence of cme since it was initially reported by irvine in 1953 . Angiographic cme is detected by fluorescein angiography and is significantly more common than clinic... |
A pigment is a coloured organic or inorganic solid that is usually insoluble in its application media . Pigments are used when extreme resistance to light, weather or temperature is needed, e.g. In automotive paints and other outdoor applications . Due to its insolubility, a pigment will usually retain its crystal stru... |
Nowadays, post - operative nausea and vomiting (ponv) sound to be the leading cause of morbidity and discomfort among pediatric surgical patients . Ponv may at least direct patients to have longer stay at hospital after surgery but some more serious consequences such as bleeding, wound dehiscence, dehydration, electrol... |
The ecology of tularemia is represented by a literature that reflects the diversity of this complex zoonosis . Like the literature of many other infections, the sheer volume of observations makes it difficult to organize and synthesize sets of working hypotheses for how the causative agent exists in nature . An organiz... |
Assessment of left ventricular (lv) function is the most common and clinically relevant task in the congenital echocardiography laboratory . Historically, those measurements have been estimated using m - mode (mm) and two - dimensional (2d) echocardiography, with several limitations . Strain echocardiography, on the ot... |
A. pereda, c. perfumo, and d. r. perez contributed to the concept and design of the study; a. rimondi, m. angel, j. ye, t. sutton, m. dibrbora, v. olivera, and m. i. craig analyzed and interpreted the virological and molecular data; j. cappuccio, m. quiroga, and m. machuca performed necropsies, analyzed, and interprete... |
The older population is increasing in sweden,1 as it is in the rest of europe.2 elderly people are and will be affected by multiple chronic conditions that is, multimorbidity3 and several mental disorders,4 even when dementia disorders are not taken into account.5 multimorbidity is associated with mental health problem... |
Since earliest times, food and nutrition have always remained one of the darkest areas and the world has failed to tackle the situation completely . The 1996 world food summit brought back to center stage the issue of hunger and food insecurity as both cause and effect of poverty and slow growth . In the wake of this n... |
The protocol was approved by the institutional review boards for human studies of baylor college of medicine, the harris county hospital district, and the university of washington . All kpd patients were identified by acute presentation with an episode of dka, defined by the presence of all of the following: anion gap ... |
Lung cancer is the leading cause of cancer - related deaths in the united states . Even after 30 years of improved therapeutic approaches, the 5-year mortality of lung cancer remains alarmingly high at 86%.1 the emerging application of pharmacogenomics offers the potential to identify drugs and drug combinations in the... |
Indeed, patients with dementia often have neuropsychiatric symptoms collectively termed behavioral and psychological symptoms of dementia (bpsd).1 depression is quite common in elderly patients with dementia.2,3 aggressive behaviors that cause great difficulties in the social functioning of patients are also common, si... |
During july 2011april 2014, a total of 45 blood samples were collected in edta - containing collection tubes from wild japanese macaques in aomori (n = 25), yamagata (n = 5), and wakayama (n = 15) prefectures in japan . The animals were captured by licensed trappers, in accordance with the wildlife protection and prope... |
As described in detail below, we first estimated the exposure - response relationship between observed daily mortality and temperature data in manhattan . We then obtained downscaled future temperature projections from sixteen climate models and two greenhouse gas emissions scenarios for manhattan . These two inputs we... |
Polyamines (pas) are small positively charged aliphatic molecules ubiquitous in almost all life forms . In plants, spermine (spm), spermidine (spd), and their precursor putrescine (put) are the major pas present in cells at micromolar - to - millimolar concentrations . Pas have been implicated in a wide range of life p... |
They include low dietary intake, conditions associated with decreased absorption or increased urinary phosphate excretion, and conditions associated with shifts in phosphate from the extracellular to intracellular fluid . The latter include various cellular uptake syndromes, in which hypophosphatemia develops as a resu... |
Osteoporosis is a metabolic bone disease characterized by loss of bone mass and disruption of bone microarchitecture, and consequently increases the risk of fracture3,5,11,14). It is well known that estrogen plays a fundamental role in skeletal growth and bone homeostasis1 - 3,6). This is of particular importance in po... |
Dacron arterial grafts are widely used in thoracic aortic replacement, but few cases of non - anastomotic aneurysmal dilatation or rupture have been reported . In most cases that have been reported, knitted, rather than woven, we report the clinically successful result of thoracic endovascular repair (tevar) of the lat... |
It was not until the year 1900, when karl landsteiner at the university of vienna, discovered why some blood transfusions were successful while others could be deadly . Landsteiner discovered the abo blood group system by mixing the red cells and serum of each of his staff . He demonstrated that the serum of some peopl... |
Homogeneous gold catalysis is a relatively new field of research that became popular in the early years of this century . Although there were a few scattered papers describing reactions of aromatic compounds with gold salts, the first signals of the synthetic potential of gold in homogeneous catalysis came with the wor... |
We describe here a method that can rapidly and accurately compute the potentials of mean force (pmfs) between spherical univalent ions in water . The pmf between an ion a and ion b represents the reversible work (as a function of distance between the two ions, r), averaged over all the configurations of the surrounding... |
The approval of five new treatments for metastatic castrate - resistant prostate cancer (mcrpc) within the last 5 years has been an unprecedented milestone in prostate cancer treatment [figure 1]. Not only have these drugs successfully changed the therapeutic landscape for this disease but at the same time these challe... |
Nppe is an uncommon complication of extubation in the early post - operative period and most commonly caused by laryngospasm . Acute laryngeal spasm results in airway obstruction and can cause life threatening pulmonary edema due to negative intra thoracic pressure . The incidence of nppe has been reported to be 0.05 t... |
Tufted angioma is a rare vascular neoplasm clinically characterized by slowly progressive pink to red macules or plaques on the neck, trunk, or shoulders of children or young adults . These tumors follow a benign course of angiomatous proliferation, without any evidence of malignancy . We report herein a case of multif... |
Upper gastrointestinal bleeding is one of the most common emergencies managed by gastroenterologists that results in high patient morbidity and medical care costs (1). The main sources of upper gastrointestinal bleeding are peptic ulcers, esophagitis, drug - induced mucosal damage, sequelae of portal hypertension (esop... |
Basal cell carcinoma (bcc) is the most common type of skin cancer in the head and neck region . The incidence of bcc is on the rise, and it represents approximately 65% of all skin carcinomas [13]. Bcc is not usually life threatening, unlike malignant melanoma, but it is locally invasive and may lead to considerable mo... |
Myocardial infarction (mi) is one of the leading causes of morbidity and mortality throughout the world . In china, a newly industrialized country, it is estimated that 3 million patients have suffered from mi and an additional 0.5 million patients experience acute mi yearly . Substantial progress has been made in myoc... |
Physical activity has been associated with better qol and fewer chronic diseases . Despite the benefits of physical activity however, physical activity programs are needed, especially in countries such as brazil, which is experiencing a rapid demographic transition and a burden of chronic diseases . In 2002, the brazil... |
Adults with type 2 diabetes inadequately controlled (a1c 711%) with maximally tolerated stable doses of metformin, sulfonylurea, or both for 3 months were randomized (1:1) to 1.8 mg liraglutide once daily or 10 g exenatide twice daily . After 26 weeks, patients continued into a nonrandomized 14-week extension: all exen... |
The origin of tumors of minor salivary glands account for less than 25% of all salivary neoplasms with 40 kleinsasser and klein introduced the term basal cell adenoma to describe a benign salivary gland tumor comprised of uniform appearing basaloid cells arranged in solid, trabecular, tubular, and membranous patterns, ... |
Autistic spectrum disorders (asds) are developmental disorders estimated to affect 1 in 150 children . Increasing professional awareness has led to higher levels of diagnosis and support, possibly explaining the recorded rise in prevalence over the last 30 years . Asd is commoner in males (m: f autism 4: 1, aspergers 1... |
Ecology is generally described as the study of the relationships between organisms and the (a)biotic environment . Such relationships are best understood as interactions because the environment is not only dictating the fate of organisms, but organisms also affect the environment . Organisms make use of their phenotype... |
Laparoscopic sleeve gastrectomy (sg) was introduced by gagner and colleagues as a first - step procedure to minimize surgical risk for super - super obese (sso) or high - risk patients, followed by either laparoscopic biliopancreatic diversion with duodenal switch or laparoscopic roux - en - y gastric bypass (rygb). Sg... |
Transposons employ intricate mechanisms of excision and reinsertion, and they appear to play an important role in the evolution of their hosts, often accounting for a substantial part of the genomes [1 - 5]. More recently, however, they have primarily attracted attention as tools for the manipulation of the genomes of ... |
Sunitinib is a small molecule multitargeted tyrosine kinase inhibitor currently used for the treatment of cancer . This class of drugs has also been reported to have antidiabetic effects [1 - 3], but the mechanism has not been elucidated . Here we describe a patient with a nonfunctioning pancreatic neuroendocrine carci... |
A new distribution for analysing time - to - event data was introduced by, known as generalised exponential distribution . Generalised exponential distribution can be used as an alternative to the well - known and used weibull distribution in lifetime data analysis and reliability engineering according to . The general... |
Supernumerary teeth can occur in primary or permanent dentition, but are more frequently reported in permanent dentition . They can occur in different forms, unilaterally or bilaterally and either in the maxilla or mandible . Supernumerary teeth may be an incidental finding on a radiograph or the cause for failure of e... |
Laboratory bacterial strains used are derived from e. coli k12 (bw25113 obtained from the coli genetic stock center or mg1655 obtained from atcc). The uropathogenic e. coli strain uti89 was kindly provided to us from matt conover and scott hultgren . The ciprofloxacin - resistant uropathogenic e. coli isolate (upec cip... |
The population of old people is rising exponentially in thailand . According to the foundation of thai gerontology research and development institute, tgri (2013) it is projected that the aged population in thailand will significantly rise to approximately 22 million by 2040 . In 25 years, 33.5% of the entire thailand ... |
The most common hospital - acquired infection is catheter - associated urinary tract infection (cauti) accounting for almost 40% of all the nosocomial infections . The single most important predisposing factor for cauti is the insertion of urinary catheter . Urinary (foley) catheters are used very frequently in hospita... |
Pit displays the characteristic histological features of a thymoma, with the additional characteristic of being surrounded by lung or visceral pleura without evidence of a thymic lesion in the anterosuperior mediastinum . Due to its rarity, variety, unclear natural course, and non - specific features on diagnostic imag... |
Web- and mobile - phone - based applications are now commonly used to improve coverage and quality of health services . In india, the mother and child tracking system (mcts) is one such web - based applications that is used nation - wide to improve the coverage of maternal, newborn, and child health (mnch) services . S... |
Recent advances in high - throughput sequencing technologies have greatly increased the scale and scope of genomics research, and this was evident throughout the recent biology of genomes meeting at the cold spring harbor laboratory . Here in one of several talks that investigated the causes, dynamics and phenotypic ef... |
The three goals of radical prostatectomy () are cancer control, preservation of urinary control, and preservation of sexual function. As the techniques of rp have evolved, our understanding of the relevant anatomy has improved and better oncological and functional outcomes have been reported . Despite this, there remai... |
Most of us agree that the assumption that nurses care and doctors cure is too simplistic, and that it is not uncommon for many nurses not to care very much at all, and for some doctors to care a great deal . However, in spite of this, there still is a theoretical discrepancy between nursing and medicine in relation to ... |
One of the major factors that can negatively affect breastfeeding is the lack of breast milk . There are many instructions on the subject of breast milk in iranian traditional medicine resources . This article attempts to investigate causes and reasons for the lack of breast milk from the perspective of the great schol... |
Over the next 30 years, the elderly population (65 years and older) in the united states is expected to double . By the year 2040, 20% of americans will be 65 years of age and older as compared to 12.97% in 2010 . From 2010 to 2050, the total population is expected to increase by 142%; the age group of 65 years old and... |
Globally, the production of canned tuna is continuously increasing and the current european market demand far exceeds the availability of raw material that the fishing areas of the european union (eu) are able to provide, forcing fish processing companies to seek new and cheaper sources of supply, such as zero duty afr... |
Mycotic aortic aneurysms are a rare condition with a relative incidence of 13% of all aortic aneurysms . The patients often present late with nonspecific symptoms, and these aneurysms are prone to rupture; therefore, early diagnosis and urgent treatment is vital . Computed tomography angiography (cta) is the first - li... |
Birth of a child with ambiguous genitalia often imparts great deal of apprehension and confusion to the involved families . Diagnostic workup and timely designation of the gender to these patients clitoromegaly refers to an abnormal enlargement of a female clitoris, thus masquerading as a male penis . Most of the cases... |
A significant quantity of food and beverages arrive on the market in a robust form of tinplate packaging . Hermetically sealed can allow minimization of headspace oxygen and also keep a long and safe shelf life with minimal use of preservatives . However, the use of tinplate for food and beverage packing will result in... |
The endothelium, the monolayer of endothelial cells lining the lumen of all blood vessels, plays an important role in the regulation of vasomotor tone control with the release of vasoconstrictor mediators.1 endothelial function can be assessed by flow - mediated dilatation (fmd) which be carried out noninvasively with ... |
Increased microglial activity facilitates beneficial responses to central nervous system (cns) injuries, including phagocytosis of debris and clearance of apoptotic cells; however, unregulated microglial activity can lead to production of neurotoxic factors that worsen cns pathology and cause neuronal degeneration [17]... |
Despite their usually low stability, organic radical cations1, 2 have raised substantial interest in a wide range of research areas owing to their critical importance in a multitude of organic and biological reactions, for which they act as reactive intermediates . Furthermore, radical cations that absorb light in the ... |
Emergency hematopoiesis defines the production of functional hematopoietic cells under nonhomeostatic, proinflammatory, or biologically stressed conditions [14]. Blood cell production is a tightly regulated process that, after birth and throughout life, starts in a conspicuous hematopoietic stem cell (hsc) subset resid... |
The accord trial design, inclusion criteria, subject characteristics, and main results have been previously published (2). The accord trial was designed to determine whether cardiovascular event rates in t2 dm could be reduced through intensive glycemic control, intensive blood pressure control, and lipid management ta... |
Abdominal compartment syndrome (acs) is a life - threatening syndrome with an increase in incidence among critically ill patients . Primary acs results from a direct injury within the abdomen and pelvic region (e.g., a blunt or penetrating trauma, ruptured abdominal aortic aneurysm or laparotomy). A direct injury to th... |
The prevalence of electronic nicotine delivery systems (ends), such as ecigarettes and vapor pens, is on the rise around the world 1 . While ecigarettes may have potential roles in assisting with smoking cessation or tobacco harm reduction 2, they are not currently approved or regulated by the food and drug administrat... |
Biomonitoring is an important way of evaluating human exposures to selected environmental contaminants and is becoming more widely used in public health work . Creatinine is often used for normalizing or adjusting urinary analyte concentrations for dilution in clinical samples and is considered an integral part of moni... |
We report a case of a 32 week gestation newborn diagnosed with a right ventricular outflow tract mass and subsequently diagnosed with tuberose sclerosis that needed early surgical intervention . While this case needed early intervention, the need for surgical intervention in otherwise asymptomatic cases is debatable as... |
The hormones dominating the phases are gonadotropin releasing hormone (gnrh), follicle - stimulating hormone (fsh), luteinizing hormone (lh), estrogen and progesterone . These hormones can be changed by exercise estrogen and progesterone increase after acute exercise . In the menstrual period, progesterone and estrogen... |
Chronic heart failure (hf) is a significant health and social problem . In the united states alone, nearly 6 million people suffered from hf in 2008, and this disease is becoming increasingly prevalent with more than 550,000 new cases diagnosed each year . Half of hf patients die within 5 years of the first onset of sy... |
Diabetic muscle infarction (dmi), which was described for the first time by angervall and stener in 1965, is a rare complication of dm . It is usually seen in long - standing dm along with complications, such as, nephropathy, retinopathy and neuropathy . Until now it commonly occurs in the thigh muscles and we have bee... |
A 43-year - old man had sudden blurring of vision, metamorphopsia, and paracentral scotoma in his left eye on the second postoperative day of dacryocystorhinostomy operation on the same side . Ocular examination showed best - corrected visual acuity of 20/20 in the right eye and 20/80 in the left eye . Fundus fluoresce... |
The use of sound information is a growing area of application of signal processing techniques in healthcare and biomedicine . In particular, multiple groups have reported on the development of systems that analyze audio recordings of patients and identify bouts of coughing [15] or other sounds indicative of health conc... |
Camel milk has been used for centuries as a medicinal drink in middle eastern, asian, and african cultures (13). Camel milk products in the world are popular due to increasing demand and are typically available in pharmacies (4). This systematic review has been conducted to evaluate the nutritional value and medicinal ... |
Tear film studies have progressed a lot in the past few years, from the traditional quantitative tests like schirmer test, and tear meniscus height measurement, and the qualitative test of tear break - up time (tbut), to anterior segment optical coherence tomography (as oct) measured tear film height and the dynamic te... |
Freeze - fracture electron microscopy was established as a major technique in ultrastructure research over 30 years ago . When biological specimens are in the frozen state, cellular bilayer lipid membranes have a plane of weakness in their hydrophobic interior; so if the sample is fractured, the fracture plane will spl... |
Thyroid eye disease (ted) is an autoimmune disease involving the retroocular tissues associated with graves' disease [1, 2]. Typical signs and symptoms include proptosis, retroorbital pain, tearing, conjunctival redness and edema, corneal lesions, impaired extraocular motility with or without diplopia, periorbital edem... |
Genital herpes is most commonly caused by infection with herpes simplex virus type 2 (hsv-2), and is one of the most prevalent sexually transmitted diseases (std) worldwide [13]. The incidence of new infections is about 1 million cases per year in the united states . At least 50 million persons in the united states hav... |
Dengue is an arboviral disease endemic in most of the tropical countries with recurrent epidemics . Although dengue is known to cause hepatic involvement commonly, it only occasionally results in fulminant liver failure (flf), which has a high mortality . N - acetyl cysteine (nac), a precursor of glutathione, is an eff... |
The choroid, a well - vascularized connective tissue, resides between the retina pigment epithelium and the sclera and extends from the ora serrata anteriorly to the optic nerve posteriorly . The choroid receives most of the ocular blood flow (~85%) and has one of the highest metabolic activities in the body . The phys... |
Applying optimum amount of force during orthodontic treatment is a challenging task for the orthodontist . Amount of force to be applied during orthodontic treatment is one of the problems encountered in orthodontics.1 the quantification of stress in the periodontal ligament (pdl) is an important concept, as stress in ... |
Cryptophane - a was the first cryptophane synthesized by collet et al . In 1981 . It is composed of two equivalent cyclotribenzylene (ctb) caps bound together by three ethylene - dioxy linkers . On each phenyl ring a has been the subject of many interesting studies in the field of host it has a hydrophobic three - dime... |
Acute myocardial ischemic injury is associated with various pathophysiological responses, including inflammatory activity with migration of neutrophils to the ischemic site . Although early blood reperfusion to the ischemic myocardium is undoubtedly beneficial in the setting of acute myocardial infarction, there is muc... |
Migraine is a highly prevalent illness, and women of reproductive ages are more affected by it than men or women in other age groups (1). Many researchers have supported the view that behavioral interventions such as biofeedback and relaxation, either alone or in combination, can be effective for the treatment of heada... |
The emerging discipline of cancer survivorship research includes the study of the consequences of cancer diagnosis and its treatment among children and adults who have experienced cancer . While the united states (usa) has conducted the majority of research on adult cancer survivorship [26], the united kingdom and cana... |
Currently, the uniprotkb protein sequence database contains> 17 million protein sequences (1). This wealth of data is helping us to understand biology at an ever increasing rate . A large fraction of these sequences can be grouped into a few thousand common protein families . Proteins within these families often share ... |
Luminescent metal complexes are increasingly employed as biomolecular and cellular probes due to their unique photophysical properties that make them particularly well suited to monitor biological processes . Examples include not only complexes of transition metals such as pt, ir, and ru but also those that incorporate... |
Mandibular angle fracture is the most common mandibular fracture, accounting for 40% of all mandibular fractures1 . Mandibular angle fracture is defined as a fracture line between the anterior border of the mandibular ramus and the body of the mandible2 . The management of angle fracture is difficult because of its thi... |
The incidence of hepatocellular carcinoma (hcc) is increasing in the united states, europe, and worldwide, and has become a serious problem in many countries . Patients with chronic liver disease related to hepatitis b or c virus infection are at high risk for developing hcc, and the risk of hcc development becomes hig... |
Over 40% of patients being treated with oral anticoagulation are prescribed a direct oral anticoagulants (doacs) according to a recent study assessing prescribing patterns 1 . Pivotal trials for the doacs have reported noninferiority or superiority of these agents to warfarin, a vitamin k antagonist (vka), for multiple... |
The neural mechanisms that underlie l - dopa - induced dyskinesias in parkinson s disease (pd) remain poorly understood [14]. Dyskinesias have been associated with pulsatile stimulation of dopamine receptors, downstream changes in genes and proteins, and changes in nondopamine transmitter systems [46]. All these change... |
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