text stringlengths 0 868k |
|---|
(sun tzu, the art of war, c.500 bc) the challenge of conducting high - quality clinical studies in the critically ill population is widely recognised . Heterogeneity in patient populations and clinical practice, diagnostic uncertainty, concerns with consent, and the overlapping nature of the presenting illnesses are am... |
We performed the pituitary gland biopsy and histochemical examination glucocorticoid therapy in a subject with igg4-related hypophysitis . This case report provides the possibility that igg4 level is decreased spontaneously or with a physiological dose of glucocorticoid therapy . We reported the clinical course of igg4... |
This prospective, cross - sectional study had ethical approval from the north west london research ethics committee (rec number 10/h0720/21). A total of 110 patients with afd (60 heterozygous females, 50 hemizygous males) were recruited between april 2011 and february 2012 from the lysosomal storage disorders unit at t... |
Steroid hormones are molecules, mainly produced by endocrine glands such as the adrenal gland, gonads and placenta, involved in the control of many physiological processes mainly in the periphery, from reproductive behaviour to stress response . In 1981, baulieu and co - workers were the first to demonstrate steroid pr... |
Nerve injury and specifically trigeminal nerve injury is known as a potential risk of many surgical procedures in the oral cavity in general [17, 23, 30]. Usually after oral implant rehabilitation, the patient expects and experiences significant improvements, not only regarding jaw function, but also in relation to den... |
The longevity of a ceramic restoration appears to be linked to its physical and mechanical properties, as well as reliable bonding between the restoration and the tooth . In order to obtain effective bonding between feldspathic ceramics and the tooth substrate, surface treatment is necessary for both the internal aspec... |
The ccc study (n = 1423), established in 2003, is an open prospective cohort of hiv - hcv coinfected individuals recruited from 19 centers across canada and represents approximately 23% of the coinfected population under care . At visits every 6 months, sociodemographic, medical, and behavioral information is collected... |
Malaria is the most important and common parasitic disease in the world caused by a protozoan of the genus plasmodium . Four species including plasmodium falciparum, p. vivax, p. ovale and p. malariae cause the disease in human (1). More recently p. knowlesi is supposed to be the fifth species of human malaria (2). Acc... |
Differential diagnoses for the relatively rare nasopharyngeal cysts include tornwaldt s disease, rathke s cleft cyst, intra - adenoid cyst, branchial cysts, and pseudocysts.1 here we report a case in which the presence of nasopharyngeal cysts was indicated as hampering nasal continuous positive airway pressure (ncpap) ... |
Rna molecules are not merely simple carriers of genetic information but can assemble into complex tertiary structures and even catalyze reactions . In fact, the existence of catalytic rna molecules (ribozymes) has led to the proposition of the rna world hypothesis . In modern cells, rna molecules catalyze just two clas... |
Increasing evidence suggests that inflammation plays an important role in the development of insulin resistance . The inflammatory status of the liver and adipose tissue, the main insulin - resistance - related organs, is critical for insulin sensitivity of the whole body [3, 4]. During development of inflammation in t... |
Acquired hemophilia a (aha) is a relatively rare and life - threatening bleeding disorder caused by spontaneous development of autoantibodies against factor viii (fviii). The reported annual incidence of aha is of the order of 1.5 individuals per million (1). The disease most commonly presents as spontaneous excessive ... |
Kinesin is a molecular motor that transports organelles along a microtubule (mt) using the energy of atp hydrolysis . Conventional kinesin is highly processive and can move across hundreds of tubulin dimers (> 1 m) without dissociating from the mt (howard et al ., 1989; block et al ., 1990). This processive movement ha... |
Since antibiotics were first discovered in 1928, they have been widely used in human and animal medicine . However, most antibiotics are excreted and enter the soil or water environments through wastewater and fertilization with manure (kmmerer, 2003). Antibiotic contamination of the natural environment has been docume... |
There is a growing body of evidence that the endocrine, nutritional and metabolic milieu during the fetal period may have lifelong programming effects. [14] therefore, it is possible to propose that newborns of the women with polycystic ovary syndrome (pcos) are exposed to an abnormal metabolic milieu during fetal life... |
White sponge nevus (wsn) is a rare autosomal dominant genodermatosis affecting the oral mucosa in the majority of the cases . Other less frequently affected sites include the nasal, esophageal, rectal and vaginal mucosa . Wsn was first reported by hyde in 1909, and cannon coined the term white sponge nevus in 1935 . A ... |
Complete formation of the root and closure of the apical foramen continues for up to 3 years following eruption of the tooth . If the pulp of young permanent teeth is damaged before the closure of the apical foramen, pulp necrosis may occur . In immature teeth, dentinal tubules are wide and allow the penetration of bac... |
One of the most daunting complications of cardiac catheterization is a cerebrovascular event (cve). Stroke after cardiac catheterization procedures occurs mostly in older patients with vascular comorbidities, undergoing complicated invasive procedures . The incidence of stroke following percutaneous coronary interventi... |
Fournier's gangrene is a rare and often fulminant necrotising fasciitis of the perineum and genital region frequently due to a synergistic polymicrobial infection . The condition was first described as a disease of young adults of unknown cause by fournier in 1888 . Others are local conditions like perianal suppuration... |
Grid laser treatment was performed in both eyes seven months ago . In spite of seven months of follow - up after grid laser with good systemic control, persistent csme was found in both the eyes with central macular thickness (cmt) of 311 m and 452 m in the right and left eye respectively [figs . Intravitreal bevacizum... |
Local analgesia, which allows a virtually pain - free treatment, plays a crucial role in paediatric dental practice . Articaine is a commonly used local analgesic that was introduced to the german market in 1976 . Experts have said that it may be the analgesic of choice in children over 4 years of age (nizharadze et al... |
However, predictors used in those models are often not actionable, as they are typically based on demographic (e.g., age, race / ethnicity) or clinical data (e.g., medical history, billing or laboratory data). In our previous work, we aimed to identify a subset of high - risk patients with reversible risk factors, as o... |
Acinar cell carcinoma (acc) of the pancreas is a rare tumor that is estimated to account for 12% of all pancreatic exocrine tumors [1, 2]. Because of the lack of clinical experience with acc, its pathophysiology is not well understood . According to previous reports, acc generally shows expansive growth without invasio... |
Partial or complete portal vein thrombosis (pvt) complicates 5 - 26% of liver cirrhosis cases, and is primarily related to stagnant portal venous blood flow in the setting of portal hypertension . The presence of pvt negatively impacts liver transplant patients; not only are auxiliary (intraoperative thrombectomy or ju... |
Lung abscess literally means a collection of pus within a destroyed portion of the lung . Therefore, the basic treatment of lung abscess consists of drainage and antibiotic therapy, which are the cornerstones of appropriate nonoperative management, with surgery reserved for special circumstances . Bronchoscopy has prov... |
A parotid fistula is a rare and extremely unpleasant complication following surgery in the maxillofacial region . Parotid fistulae have been reported following surgery in the temporomandibular joint (tmj) region, parotidectomy or secondary to drainage of facial / parotid abscess, and the incidence reported is as high a... |
Figure 6 outlines the fabrication process of our devices . We start with a commercial silicon on insulator (soi, from soitec) substrate with a 340 nm p - type (7 10 cm) si layer on top of a 2 m buried oxide (box). First, a 100 nm sin mask is deposited by plasma enhanced chemical vapor deposition (pecvd, oxford plasmala... |
Ischemic stroke is a disease with substantial etiologic heterogeneity, including large artery atherothrombotic disease, small artery atherothrombotic disease, cardioembolism, and other subtypes . Hmg - coa reductase inhibitors, or statins, are established therapeutic agents for the prevention of atherosclerotic - based... |
Extravasation refers to the unintended leakage of a liquid formulation of a drug from blood vessels into surrounding tissues . Extravasation of anticancer drugs administered by intravenous infusion constitutes a serious adverse event associated with chemotherapy . In particular, the extravasation of drugs with vesicant... |
The celiac trunk (ct) is the first ventral branch of abdominal aorta and arises at the level of t12/l1 . The main branches of ct include left gastric, common hepatic, and splenic arteries . Ct supplies the primary organs of the supracolic abdominal compartment . After arising from ct, the common hepatic artery runs dow... |
Approximately 20% of undescended testes are truly impalpable, and laparoscopy is actually regarded as the gold standard for their localization; none of the currently available imaging techniques (ultrasound, computerized tomography, or magnetic resonance imaging) has proven to be 100% reliable in predicting the presenc... |
The significance of low - level laser in clinical medicine began with the important works of endre mester . In recent years, the various clinical applications of low - level laser therapy (lllt) have mainly been based on previous scientific works concerning the effect of low - level lasers, which exert a positive influ... |
. However, stroke trials did not include patients with either non - witnessed strokes or wake - up strokes . Patients presenting stroke with symptoms that began at an unknown time represent around 30% of patients with acute stroke, while around 20% of stroke admissions are for wake - up stroke . Although acute reperfus... |
Incisional (postoperative ventral) hernia is an iatrogenic abdominal wall defect that occurs at the site of previous incision following breakdown in the continuity of the fascia closure . It has been described as a bulge visible and palpable when the patient is standing and often requiring support and repair . It is a ... |
Primary disorders of tendons are common and account for a high proportion of referrals to rheumatologists and orthopaedic surgeons . The most commonly involved tendons are the rotator cuff (particularly supraspinatus) in the shoulder, the forearm extensor (tennis elbow) and flexor tendons (golfers elbow) in the forearm... |
Iatrogenic injury of the lumbar arteries after spinal surgery is a rare complication5 - 9). It may result in the formation of a pseudoaneurysm and consequent acute or delayed retroperitoneal hemorrhage . Because pseudoaneurysm develops gradually from a focal arterial wall disruption however, this condition may lead to ... |
The goal of platelet transfusion is to stop or prevent bleeding in thrombocytopenic patients or those with platelet dysfunction [1 - 3]. Bleeding is a relatively uncommon cause of death in non - trauma patients but can be a significant morbid event at worst and, at best, quite upsetting for patients, families, and prov... |
Hepatitis b virus (hbv) is a hepatotrophic virus that causes a major global health problem . An estimated 2 billion individuals have been infected with hbv and approximately 350 million have the chronic disease . Although the mechanism of hbv pathogenesis remains elusive, host genetic factors are proposed to govern the... |
Obesity has become an increasingly important global health problem . Currently, 13% of the world's adult population aged 18 years and older are obese, with a body mass index (bmi) 30 kg / m . In 20082011, 23% of the male and 24% of the female adult population in germany had a bmi 30 kg / m . Bariatric surgery is the mo... |
Acute rejection (ar) is a major risk factor for chronic allograft nephropathy and renal allograft failure after kidney transplantation . The banff classification criteria divided ar into acute cellular rejection (acr) and acute humoral rejection . T cell mediated rejection, as it is associated with cytotoxic t cell inf... |
In the last two decades, li - ion batteries (libs) have occupied the portable - electronics market as a primary power supplier with a higher gravimetric and volumetric capacity than other rechargeable - battery systems (e.g., ni cd, lead acid, redox - flow, and metal - ion batteries). However, current lib technologies ... |
The pregnancy - associated glycoproteins (pags) constitute a large group of proteins belonging to the aspartic proteinase superfamily expressing in the placenta of eutherian mammals . Pags are acidic glycoprotein sharing more than 50% amino acid sequence identities with pepsin, cathepsin d and e . They are secreted fro... |
Anaesthesia for mediastinal masses presents a topic for debate as to the questionable advantages of general anaesthesia (g.a . ). However, successful management with minimal complications is reported of late due to well - balanced g.a . In such surgeries . The mediastinum is the most common site of chest masses in chil... |
Use of radioactive pharmaceuticals for diagnostic nuclear medicine procedures is one of the main sources of radiation exposure resulting from ionizing radiation to populations . Annual assessment of patients absorbed dose can give a quantitative estimate of per capita population absorbed dose . Risk of exposure to ioni... |
The study of k - string composition of long dna sequences including complete genomes is a natural extension of g + c content, i.e., k = 1, analysis . Using k values greater than 1 takes into account short - range (up to k 1) correlations of nucleotides and enhances species - specific features in the sequence . Visualiz... |
Mesenchymal cells are precursors for a varied group of connective tissue cells including endothelial cells, smooth muscle cells, pericytes, chondroblasts, adipocytes, osteoblasts, odontoblasts, and fibroblasts . The interrelationships between cell lineages and differentiation potential contribute to wide range of synth... |
It makes sense to prioritise actions on the small number of behavioural factors which are the leading determinants of health.1 2 on the contrary, other more costly technocratic approaches seem to be playing the dominant role in current public health policies . Emphasising medical devices over lifestyles can potentially... |
Syphilis is a sexually transmitted disease caused by infection with the bacterium treponema pallidum whose diagnosis remains elusive . The introduction of penicillin approximately 60 years ago along with public health improvements led to a decline in syphilis infection rates.1 however, after the rise of acquired immuno... |
Partial - thickness rotator cuff tears (ptrcts) have the potential to cause significant pain and disability in affected patients . After failed conservative management, operative intervention is typically indicated for patients with persistent symptoms . Surgical treatment is generally limited to tear debridement with ... |
Throughout the 70 s of the 20th century, investigations on a new class of pharmacologically active substances actoprotectors (aids for improving human s physical and mental efficiency) were guided by professor vladimir vinogradov . These investigations resulted from the development of the first and the most commonly us... |
Bacterial infection in newborns, especially preterm, may rapidly evolve into generalized sepsis . This condition has a gradual and subtle onset, with nonspecific symptoms that may severely compromise the infant s clinical state if untreated and lead to life - threatening consequences . Neonatal sepsis has a fairly low ... |
The physical and mechanical properties of photo - cured composites are directly influenced by the level of conversion attained during polymerization . The degree of conversion (dc) is determined by the proportion of the remaining concentration of the aliphatic c = c double bonds in a cured sample relative to the total ... |
Nonsteroidal, plant - derived compounds that disrupt or mimic the normal action of estradiol are referred to as phytoestrogens . Those that disrupt or mimic the action of testosterone or dihydrotestosterone are referred to as phytoandrogens . These chemicals influence endocrine activity in animals and have been shown t... |
Congenital heart disease encompasses a variety of lesions that may include communication / s between the left and the right side of the heart . Such communications may cause volume overload in the short and medium term, possibly resulting in heart failure, or irreversible complications in the long term such as eisenmen... |
Nosocomial infections, also called healthcare - associated infections are those infections acquired by a patients as a result of treatment in a hospital, clinic or healthcare service centre . These infections generally appear 48 hours or more after hospital admission or within 30 days after discharge . They occur becau... |
Autistic spectrum disorder (asd) is seen in all races, cultures, and societies . Asds are also known as pervasive developmental disorders (pdds). In diagnostic and statistical manual - text revised (dsm - iv - tr), pdds included autism, asperger s, pdd - not otherwise specified (pdd - nos), disintegrative disorder, and... |
According to a recent survey conducted by harvard school of public health and alzheimer's europe consortium on alzheimer's disease (ad), dementia of the alzheimer's type is a major cause of health concern in adults . A similar trend is predicted in most countries in sub - saharan africa (ssa) where the proportion of el... |
Almost 170 million people are infected with hepatitis c virus (hcv) globally, which accounts for 2 to 2.2 percent of world population . The virus prevalence is various in different countries and has been reported between 0.1% and 12% . The main routes of this virus transmission are through blood, sexual contacts and sh... |
Ultrasound has been widely used for rapid assessment of critical illness and is regarded as a visual stethoscope . There are few reports on the diagnosis of intracranial lesions by ultrasound in icu patients . Here we present a multiple trauma patient who had undergone craniectomy and in whom recurrent intraventricular... |
The holt oram syndrome is characterized by congenital cardiovascular malformations and skeletal abnormalities of the upper limbs, hence, the terms heart - hand syndrome and heart upper - limb syndrome . Arm deformity covers a wide range of anomalies extending from minor abnormalities, through to serious, even handicapp... |
Hba1c is a retrospective analyte of the carbohydrate metabolism reflecting the mean blood glucose levels during the last 6 to 8 weeks . Clinical studies revealed a close relation between late diabetic complications and the concentration of glycated proteins in blood . Therefore hba1c determination is widely used to ass... |
The mammary gland is currently the only readily available animal bioreactor, but optimized expression vector construction is required for transgenic expression of recombinant proteins, and expression vectors still have strides to make [1, 2]. One strategy for optimized expression vectors includes using elements like in... |
Albuminuria (i.e., urinary albumin, or ua) is defined as an abnormally high amount of albumin in the urine and is a strong sign of early renal damage [14]. In type 2 diabetes and nondiabetic subjects, albuminuria is also associated with early- and long - term cardiovascular mortality [5, 6]. Elevated ua reflects a gene... |
Nocturnal enuresis (ne) is defined as nighttime bedwetting after developmental age when bladder control should have been established . Anatomical and functional integrity of noradrenaline, dopamine and serotonin systems is required for continence . Iatrogenic ne is an adverse event commonly reported in patients taking ... |
A total of fifty male wistar rats (taconic), 12 weeks old, with a weight of approximately 360 g at arrival, were placed in makrolon iii cages in an open system, with five animals in each cage . They were kept under standard laboratory conditions with 12 h dark12 h light cycles and temperature 22 1c, relative humidity 5... |
The presence of postoperative seromadesis is common, corresponding to the presence of serum in the subcutaneous tissue post a surgical event . We present a case of a 63-year - old woman having undergone femoral prosthesis surgery and total hip replacement with a subfacial seroma without findings of infection, refractor... |
Allostasis is the process by which living organisms maintain biological homeostasis during a diverse array of challenges, including those of an environmental or physiological nature.1, 2 it is thought that cumulative effects of stress (repetitive or continuous), referred to as allostatic load, affect several physiologi... |
Ileostomy formation is occasionally required in patients with complicated inflammatory bowel disease requiring colonic resection . This procedure can lead to a number of recognised complications including stomal obstruction, stomal prolapse, skin erythema and ileal inflammation . A less commonly described complication ... |
Although it provides favorable results in terms of strength, form and function, it usually shows unaesthetic appearance from metal underneath, especially at the cervical part of the restoration or from the opaque porcelain layer.1 in addition, metal substructure obstructs the light transmission to underlying natural to... |
With these words in 1937, there began a worldwide appeal to establish a chiropractic hospital at the palmer school of chiropractic (psc):does not the reader agree with me that the next great step forward ought to be the establishment at the psc of a wonderful chiropractic hospital, to which patients of all classes, fro... |
A spinal subdural hematoma (sdh) is a rare clinical entity that accounts for only 4.1% of all spinal hematomas . It can be caused by major or minor trauma and iatrogenic injuries, such as those resulting from spinal punctures performed for diagnostic or anesthetic purposes5). Simultaneous intracranial and spinal sdhs a... |
The most common causes of hypercalcemia are malignancies, particularly solid tumors, in hospitalized patients1 and primary hyperparathyroidism in non - hospitalized patients.2 the most common cause of primary hyperparathyroidism is a solitary parathyroid adenoma.2 neck ultrasound and dual - phase tc-99 m sestamibi (mib... |
To report the case of a patient with unilateral idiopathic macular telangiectasia (imt) associated with type 3 neovascularization . We describe a case of an 85-year - old woman who presented at our department with a gradual vision loss in her left eye (le). Fundus examination showed 2 small hemorrhages located nasally ... |
Schwannoma also called as neurilemmoma is a benign neoplasm of the schwann cells surrounding the nerves . . However, intraosseous schwannoma are extremely rare in jaw bones and represent less than 1% of benign primary tumors of the jaws . A 42-year - old man hailing from dakshina kannada district in karnataka, india, r... |
Gynecomastia occurs due to increase level of estradiol, decreased androgen level or imbalance between estrogen and androgen . Familial gynecomastia occurs because of increased peripheral aromatization in families and due to inversion in chromosome 15q21.2 - 3 resulting in increased estrogen production in fatty tissue .... |
Ultrasensitivity, or threshold behaviour, where small changes in a stimulus near some threshold value produce a large change in a response, but large changes in the stimulus far from the threshold produce small changes in the response (i.e., a sigmoidal stimulus response curve), is an important property of many biologi... |
A 77-year - old woman suffered wallenberg syndrome after a stroke in the territory of the left vertebrobasilar artery . Three years later, she came to our hospital complaining of chronic lancinating left eye (os) pain of two years' duration . She was being treated in the pain unit for left hemifacial pain, and she had ... |
The ultimate goals of endodontic treatment are complete removal of bacteria, their byproducts, and pulpal remnants from infected root canals . Endodontic medicaments have been thought to be an essential step in killing the bacteria in root canals . Calcium hydroxide is the most widely used medication because of its wel... |
Eighteen eyes from 18 healthy new zealand white albino male rabbits obtained from the laboratory animal resource center, kafkas university (kars, turkey); aged 10 to 12 months and weighting between 3 and 3.5 kg were used in the study . The study was carried out in accordance with the animal ethical guidelines for inves... |
The majority of suicides (85%) in the world occur in low and middle - income countries . Non - fatal suicide attempts occur mostly in young persons and are up to 10 - 40 times more frequent than suicides . Persons with a history of previous suicide attempt are at a high risk of dying by suicide with up to 2% dying with... |
Supernumerary teeth may be defined as any teeth or tooth substance in excess of the usual configuration of 20 deciduous, and 32 permanent teeth . Supernumerary teeth may occur singly, multiply, unilaterally or bilaterally, and in one or both jaws . Rajab and hamdan reported in their study that males were more affected ... |
Cardiovascular diseases (cvds) account for nearly a third of all deaths worldwide . The key intervention in cvds is to identify risk factors early and initiate therapy to control them . Hence, diagnosis of hypertension and appropriate treatment to optimize bp are important public health goals worldwide . All groups of ... |
Malrotation of the midgut is an abnormality in embryological development of gastrointestinal tract . By the fourth intrauterine week the gastrointestinal tract is in the form of an endoderm lined tube divided into fore, mid- and hindgut . Mid- and hindgut defined by their blood supply the superior and inferior mesenter... |
In japan, there was no choice of medication for the treatment of alzheimer s disease (ad), other than donepezil, for more than a decade, as rivastigmine, galantamine, and memantine were not approved by the japanese ministry of health, labour and welfare until 2011 . The recent availability of the three medications is l... |
Although rheumatic heart disease is increasingly rare in developed countries, it remains the most common cardiac disorder in much of the world . Percutaneous mitral valvuloplasty has been shown to be a new therapy for patients with mitral stenosis and has achieved excellent results in the majority of patients with seve... |
Warfarin is the most widely used anticoagulant agent for the prevention of stroke or systemic thromboembolism in patients with atrial fibrillation . However, warfarin has a narrow therapeutic range of international normalized ratio (inr) and is known to have multiple interactions with drugs, food, and herb . There is s... |
Cells and culture conditions the following cells were used: bhk21 (c-13) fibroblasts (baby hamster kidney clone 13, american type culture collection), bhk21-tta / anti - clathrin heavy chain (chc) cell line (30), cav-1-ko and cav-1-wt mouse endothelioma cell lines (31), c2c12 mouse myoblasts (32), and 3t3 mouse fibrobl... |
We present a case of status epilepticus due to cerebral amyloid angiopathy - related inflammation, successfully treated with immunomodulation . A 52-year - old man with a history of hypertension and alcohol abuse, presented in january of 2015 with new - onset seizures . The patient's family first noted new - onset irri... |
The medical records of all subjects evaluated by a glaucoma specialist (krs) from march 2008 to may 2015 in the glaucoma clinic of the asan medical center were retrospectively examined . Initial testing included a comprehensive ophthalmologic examination, including a review of the medical history, measurement of best -... |
Attention - deficit and hyperactivity - disorder (adhd) affects 58% of the worldwide childhood population, it has high comorbidity and it shares symptoms with other behavioral and emotional disorders (boyle et al ., 2011; larson et al ., 2011). Adhd prevalence rates vary significantly between and within countries, and ... |
Clear cell carcinoma (ccc) is a low grade malignant neoplasm representing approximately 1% of all salivary gland tumors . The differential diagnosis of clear cell salivary neoplasms encompasses a broad range of possibilities, including primary salivary clear cell tumors, such as ccc, epithelial - myoepithelial carcinom... |
In rhegmatogenous retinal detachment, the neurosensory retina becomes separated from the underlying retinal pigment epithelium (rpe), resulting in many biochemical and structural changes [14]. Morphological studies provide evidence that the most obvious detachment - induced damage within the neurosensory retina is shor... |
For almost a century, drug discovery was driven by the quest for magic bullets, which act by targeting one critical step in a disease process and elicit a cure with few other consequences . However, this concept is far from biological reality, and even the most successful rationally designed drugs (such as gleevec) sho... |
Microbial adhesion takes place on all natural and man - made surfaces (1) and poses considerable threats in food processing, drinking water systems, and human health to mention a few . These threats are not always associated with adhering organisms, but often with their detachment causing contamination elsewhere . In h... |
Loop prediction is generally one of the most challenging tasks in protein structure determination and modeling (117). The preferred conformation of loops often remains unclear even when the rest of the protein is resolved at high resolution . This is due to the high flexibility of loops that is often related to their f... |
Osteopetrosis (op) has also called with its historical names as a albers - schnberg disease, which was firstly described by a german radiologist [1, 2]. The main cause of the disease is osteoclastic activity defect, which results hypersclerotic fragile bone [3, 4]. Autosomal recessive op (aro) has a two subtype, which ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.