text stringlengths 0 868k |
|---|
Haemophilus spp . Generally colonize the upper respiratory tract and can cause infections such as bronchitis, sinusitis, epiglottitis, pneumonia and meningitis . H. influenzae has been reported as a rare cause of genitourinary tract infection such as urinary tract infection,,,,, pyelonephritis,, prostatitis, epididymit... |
The long - term survival of patients with hematological malignancies has improved dramatically over the past decades . Nowadays, about 40% of patients with acute leukemia or high - grade non - hodgkin lymphoma survive for more than 5 years and about 30% of these patients can be cured . Unfortunately, owing to their und... |
Chronic hepatitis c (chc) is a major health care burden and a leading cause of end - stage liver disease and hepatocellular carcinoma (hcc) worldwide . Although non - uniform distributions of chc in certain areas complicate the establishment of global and regional epidemiology, the global prevalence of chc has been est... |
Endometrial carcinoma is the most common cancer of the female genital tract in the western world . Endometrial carcinomas are generally thought to have a favorable prognosis due to early detection, and the majority of tumors are detected in early stages . However, in fact this is not fully true, and there are important... |
Fistula - in - ano is an abnormal hollow tract lined by unhealthy granulation tissue connecting a primary opening in the anal canal to a secondary opening in the perianal skin . The fistula tract may be single or multiple and may extend from the same primary opening . It is nearly always caused by a previous anorectal ... |
Congenital coarctation of the aorta is a narrowing of the descending aorta which typically is located at the ligamentum arteriosum just distal to the left subclavian artery . This condition may be undiagnosed until adult life, when the clinical presentation most often is high blood pressure (bp) in both or more seldom ... |
Multistep skin carcinogenesis assays were performed with mice with keratinocyte - specific deletion of the cnb1 gene (cnb1xk5-crepr1)3 in parallel with cre - negative controls (cnb1). Detailed conditions for these assays as well as chromatin immunoprecipitation, immunoblotting, immunofluorescence, senescence -galactosi... |
Micrornas (mirnas) are single stranded non - coding rna molecules of 22 nucleotides (nt) that regulate gene expression via post - transcriptional and/or translational repression (ambros, 2004). Primary mirna (pri - mirnas) are transcribed in the nucleus by rna polymerase ii or iii, where 70 nt stem - loop mirna precurs... |
Prostate cancer, one of the most commonly diagnosed male malignancies in western countries, is now the leading cause of cancer - related death in men . Over the years, genetic epidemiological evidence has accumulated in favor of a considerable hereditary component in prostate cancer susceptibility . Genetic linkage ana... |
Gli2 mice, in which the bovine k5 promoter drives the constitutive expression of mouse gli26, develop bcc and bfh6,7, which are both linked to deregulated hh signaling in humans7,8 . Gli2 mice show a reproducible pattern of lesions on the ear that successively involves hyper - keratosis (flaking), thickening and hyperp... |
Most vertebrates are unable to grow and reach their normal adult form without the thyroid hormone [1, 2]. However, various subsequent studies revealed that thyroid hormone plays a key role in rat testis development [47]. Mammalian testis is a target of thyroid hormone action and altered thyroid function which is known ... |
Ewing's sarcoma family of tumors are a group of small round - cell neoplasms, which include ewing's sarcoma (ews), primitive neuroectodermal tumor (pnet), askins tumor, pnet of the bone, and extraosseous ewing's sarcoma (ess). Ewing's sarcoma / peripheral primitive neuroectodermal tumor, presumed to be neuroectodermal ... |
Nitric oxide (no) is known to have several important vasculo - protective effects (el - mas et al 1997; grdal et al 2005). Reduced production of no may lead to atherosclerosis (lscher and vanhoutte 1990; harrison 1997; shimokawa 1999). The synthesis of no from the amino acid, l - arginine, is catalysed by no synthase (... |
It is located at the interface of these two vastly different environments, and thus is charged with making the final decision about what, from an uncontrolled and often hostile chemical surround, should be incorporated into the highly controlled biochemical environment within . Taste is the beginning of a long chemosen... |
A 36-year - old man visited the emergency department of inje university haeundae paik hospital with severe pain in both lower limbs for 1 day . A physical examination revealed pale, pulseless, and cold lower limbs . One year ago, he had been diagnosed with kimura disease (kd) after excision of a right upper limb mass (... |
Businesses offering goods and services to consumers often request feedback from former customers to assess strengths and weaknesses and to leverage positive feedback and testimonials as marketing materials . As these testimonials become more digitized and more public on sites like yelp, facebook, and google+, businesse... |
The majority of japanese patients with type 2 diabetes mellitus are not obese, as reported by kosaka and ogata more than 50 years ago . Eastern asian subjects might share common characteristics of the disease, comparable to those reported in korean people . It is, therefore, debatable whether we can apply epidemiologic... |
Monoamine oxidases (mao) are mitochondrial enzymes responsible for the metabolic breakdown of monoamines (serotonin, norepinephrine, and dopamine) in neuronal tissues causing depletion of monoamines and clinical depression; while mao inhibitors (maois) result in the clinical improvement of mood states . Interestingly, ... |
Aerobic ammonia oxidation, the first and rate - limiting step in nitrification, is the only biological process converting reduced to oxidized inorganic nitrogen species on earth . For over 100 years, this process was thought to be mediated by autotrophic beta - proteobacteria and gamma - proteobacteria (aob) occasional... |
Chronic obstructive pulmonary disease (copd) is a chronic respiratory disease characterized by a progressive decline in lung function and accompanied by respiratory symptoms, primarily dyspnea, cough, and sputum production.1,2 given the progressive nature of the disease, the aim of treatments is to reduce symptoms and ... |
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both (1). The chronic hyperglycemia of diabetes is associated with long - term damage, dysfunction, and failure of different organs, especially of eyes, kidneys, nerves, heart, and bl... |
Acute right heart syndrome (arhs) may be defined as sudden deterioration in the right ventricular (rv) function and failure of the rv of the heart to deliver adequate blood flow to the pulmonary circulation, resulting in systemic hypoperfusion . In the context of critical illness evidence of central venous pressure (cv... |
In rare conditions, bacteria from carbuncles can spread into the bloodstream and migrate to other areas of the body, causing serious complications such as septicemia and infections in the liver, bones, joints, heart, and central nervous system . We describe an original case of forehead carbuncle with intractable headac... |
Hydroxyl radicals, generated by cellular oxidative stress and inflammation, damage nucleobases or deoxyribose sugars, or both in dna . At 2-deoxyguanosines, hydroxyl radical - mediated hydrogen abstraction at the deoxyribose c5-position followed by attack at the guanine c8 carbon forms an n7-centered radical, which may... |
The collective arrangement of the teeth in function is quite important and has been subjected to a great deal of analysis and discussion over the years . As the mandible moves laterally, the lower posterior teeth leave their centric contact with the upper teeth and travel sideways down a path dictated by the condyles i... |
Zinc deficiency is an important cause of morbidity due to infectious diseases and growth - faltering among young children . Increased demand of zinc due to rapid growth and decreased intake of zinc due to inadequate feeding practices predispose preschool children, especially living in communities of low socioeconomic l... |
Intradural disc herniation (idh) is a rare disease and its incidence is reported as 0.26 - 0.30% of all disc herniations16). Idhs primarily occur as a result of chronic degenerative diseases and rarely occur due to traumatic events1,14). Traumatic lumbar spine lesions usually result in bony fractures and paraspinal sof... |
Initially, they were considered as metastasis from an occult primary tumor in gonads, but now it is known that they arise either as a consequence of abnormal migration of germ cells during embryogenesis or from a different histogenetic origin . Choriocarcinoma of liver without a detectable primary tumor in gonads, retr... |
Human ifn-2 (il-28a) is a relatively new cytokine, in which the genomic structure resembles that of the il-10 family, but the protein structure is more closely related to type i ifn than to interleukin- (il-) 10 [1, 2]. For example, it can induce antiviral activity in cell lines, though the potency is weaker than other... |
Sodium nitrate (nano2) is one of important environmental toxicants and poses important health risks . Most countries use nano2 as food additive as a source of color and flavor preservation in meat products and this chemical can also be found in water resources . Consumption of nano2 at low levels for long time caused h... |
Placental polyp is a somewhat pedunculated remnant of chorionic tissue retained in the uterine cavity for an indefinite time . It may result in abnormal uterine bleeding and slightly elevated detectable titers of serum -human chorionic gonadotropin (hcg). These pedunculated masses of villi are often found within days t... |
Halogen bonding has emerged in recent years as an effective alternative to hydrogen bonding in directing the formation of self - assembling architectures, with fruitful applications in many chemical and biological systems . Halogen bonding is an electrostatically driven noncovalent interaction between a halogen atom in... |
In recent years, the development of an integrated nanotherapeutic system which can allow for an online imaging and deliver targeted therapy has been the subject of interest in clinical oncology . This emerging nanotechnology has allowed the manipulation of nanoparticles (nps) to assume multiple functionalities.14 inter... |
Benign prostatic hyperplasia (bph) is found in over half of 60-year - old men and in almost all 80-year - old men who develop bladder outlet obstruction (boo) and lower urinary tract symptoms (luts). Boo is the initial pathophysiological change caused by an enlarged adenoma and is followed by detrusor overactivity (do)... |
Apert syndrome (acrocephalosyndactylia) is a developmental malformation characterized by craniosynostosis, a cone - shaped calvarium (acrocephaly), hypertelorism, midface hypoplasia, pseudo cleft - palate, a parrot beak - shaped nose, pharyngeal attenuation, and syndactyly of the hands and feet.1 - 3 the inheritance of... |
Electrostatic potentials and free energies were calculated with a modified version of the delphi program, adapted to solve the nonlinear poisson - boltzmann equation for protein - membrane systems . Delphi yields finite - difference solutions to the poisson - boltzmann equation (the fdpb method) for a system where the ... |
, it accounts for the largest number of deaths from malignant neoplasms in women and the third largest number in men . However, since the recurrence rate of t1 colorectal cancer (invasion no deeper than the submucosa) without lymph node metastasis is approximately 1%, the outcome of t1 colorectal cancer is considered t... |
The cases were collected from our melanoma database, and 30 patients who were treated from january 2001 to december 2010 were retrospectively reviewed . Medical records were reviewed for demographics, clinical and pathological information, immediate as well as remote postoperative events and outcomes, with a minimal fo... |
Granulocyte macrophage colony - stimulating factor (gm - csf) is a hematopoietic growth factor which was originally recognized as a stimulator for the proliferation of granulocytes and macrophages from bone marrow precursor cells . It has also been shown to promote the survival and activation of mature myeloid cells an... |
Hypertrophic cardiomyopathy (hcm) is the most common cause of sudden death in young patients . Whereas especially patients with a nonobstructive form of hcm are thought to stay stable for a long time; a small distinct subset of patients can develop end stage heart failure, which includes a reduction of systolic functio... |
Bacteriocins are toxins produced by the bacteria to inhibit the growth of similar or closely related bacterial strain(s) during stress conditions . They are structurally, functionally, and ecologically diverse, produced by almost all major lineages of eubacteria and archaebacteria . Ribosomal encoded bacteriocins are g... |
Comet lysis buffer (2.5 m sodium chloride, 100 mm edta (ph 8.0), 1% sarkosyl, 10 mm tris hcl (ph 8.0), 10% dmso, 10% triton x-100). Comet alkali solution (0.3 m sodium hydroxide, 1 mm edta). Cryopreservation medium (50% foetal calf serum [fcs], 10% dmso, 40% dulbecco's modified eagle's medium [dmem]). Culture medium fo... |
Telemedicine utilization is rising due to the increased availability and decreased cost of communication technology, in parallel with growing recognition of key areas of health care that may benefit from its use . Although phone communication continues to be a common form of patient - provider communication, internet -... |
Chromosome 22q13.3 deletion syndrome is a well - recognized cause of global developmental delay (gdd) [1, 2] while duplication of the same chromosome is a rare occurrence [35]. The presence of both abnormalities in the same family has never been reported, to our knowledge . We report the presence of 22q13.3 deletion an... |
In this study, we retrospectively selected 75 cases of formalin - fixed, paraffin - embedded hair - bearing adult skin samples between 2002 and 2009 at asan medical center . Samples were taken from the margins of routine surgical procedures such as excisional biopsy or excision for benign / malignant skin lesions that ... |
Glaucoma remains the third or fourth most common cause of blindness in different regions around the globe . Since this is a treatable disease, early diagnosis and adequate follow - up are gaining importance . Also, direct and indirect economic burdens tend to increase for governments with patients extended lifetime exp... |
In order to introduce a new plant variety to the markets commercially, it is necessary to register a newly bred variety, which relies upon the results of dus (distinctness, uniformity, and stability) tests; that is, for a new genotype to be registered as a commercial variety, it needs to be distinct (d) from all other ... |
Sequence - defined biopolymers, such as proteins and nucleic acids, incorporate backbone and side - chain constituents that endow these macromolecules with the ability to fold into well - defined secondary and tertiary structures . The complexity and functionality of these folded biopolymers has spurred intensive resea... |
Malaria remains a serious global health problem, killing more than one million people per year . The number of malaria cases has fallen by more than 50% in 43 countries over the past decade . A modeling analysis of malaria prevention activities in 34 african countries suggested that about 730,000 lives were saved betwe... |
Hydrocephalus refers to the accumulation of excessive cerebrospinal fluid (csf) within the brain or cranial vault . Medical treatment of hydrocephalus, which aims to reduce csf production, is usually only palliative . Surgical shunting of csf from the ventricular system to another body cavity, usually the peritoneum an... |
Between 25% and 30% of non - small cell lung cancer (nsclc) patients will develop metastatic disease in the brain (brain metastases from non - small cell lung cancer frequently they are the first site of recurrence in early - stage nsclc patients treated with definitive therapies [15]. The prognosis is poor for untreat... |
Many organs can be herniated into the scrotum such as small intestine, appendix, colon, and ovaries . Ureteral herniation is extremely rare, usually asymptomatic and is reported as isolated case report or small series . We report the case of an 88-year - old man treated for inguinoscrotal hernia where the left ureter w... |
The incidence of non - hodgkin lymphoma (nhl) is 100200-fold higher in hiv - infected individuals than in the general population . Nhl is an aids - defining illness and in 35% of cases, the lymphoma is the initial manifestation of aids . The most common hiv - associated lymphomas are diffuse large b cell lymphoma (dlbc... |
Cardiovascular disease (cvd) is the main cause of death in maintenance hemodialysis (mhd) patients . Both aortic artery calcification (aac) and cardiac valve calcification (cvc) have a high incidence in dialysis patients . The diagnosis of vascular calcification is usually based on very expensive and highly technical d... |
In an era of finite resources and ever - increasing medical possibilities, every health care system faces challenges in determining which new health technologies, including medical devices, should be introduced into clinical practice.1 while technology can improve safety2 and have other benefits, it can also bring new ... |
In anterior cruciate ligament (acl) reconstruction, the use of bone patellar tendon bone graft (bptb) has been decreasing due to increased anterior knee pain, weakness of extensor power and difficulty of kneeling position . Instead, the use of hamstring tendon has been increasing1,2); however, the disadvantages of hams... |
Autosomal - recessive renal tubular dysgenesis (ar - rtd) is a rare inherited disorder caused by mutations in the genes encoding any of the components of the renin angiotensin system (ras) including renin, angiotensinogen, angiotensin - converting enzyme (ace) and type 1 angiotensin ii receptor . Fetuses may die in ute... |
Patients with ibd should be periodically examined regarding their dermatologic conditions . In a previous report from iran, the prevalence of dermatological manifestations was reported to be 5.9% in patients with ibd with a higher rate in crohn s disease (7.29%) compared with patients with ulcerative colitis (4.07%). T... |
Sepsis is the main cause of mortality in pediatric intensive care units (picus). It is caused by numerous infectious agents, inducing multiple organ dysfunction syndrome (mods), multiple organ failure (mof), and even death . Several studies have demonstrated that the severity of sepsis, as well as early diagnosis and p... |
Rna can play an important functional role in catalysis, e.g. Ribozymes are rna enzymes that cleave rna phosphodiester bonds at specific sites (1); see (2) for an overview of potential therapeutic applications of ribozymes to cleave mrnas of oncogenes (ras or bcr - abl) and viral transcripts (hiv-1), to overcome drug re... |
Central neuropathic pain (central pain) is pain caused by a disease or lesion in the central nervous system . Central pain develops in about 8% of stroke patients (andersen et al 1995), 25% of patients with multiple sclerosis (osterberg et al 2005), and 40%50% of patients with spinal cord injury (budh et al 2003; sidda... |
Toxic cyanobacterial blooms in eutrophic lakes, ponds, and reservoirs are a common occurrence around the world [13]. Cyanobacteria of the genera microcystis, anabaena, nostoc, and planktothrix produces a wide range of potent toxins, including a family of heptapeptide hepatotoxins, referred to as microcystins (mcs). Mic... |
Pancreatic heterotopia is defined as the presence, outside its usual location, of pancreatic tissue which lacks anatomical and vascular continuity with the pancreas proper (1). The heterotopic pancreas (hp) is a relatively uncommon congenital anomaly, with an incidence between 0.55% and 13.7% in autopsy series and mean... |
Cytomegalovirus (cmv) infection still remains a major cause of morbidity and mortality in allogeneic stem cell transplantation (sct) recipients . While cmv infection of the central nervous system (cns) in acquired immune deficiency syndrome patients has been reported relatively frequently, it is an unusual presentation... |
Lateral gene transfer (lgt) is a phenomenon central to prokaryotic evolution and adaptation . With the increasing use and sophistication of genomics technologies and bioinformatics tools, estimates of the extent of laterally transferred genes a recent study estimated that an average of 81% of the genes in any given pro... |
Diabetes mellitus (dm) is a clinical syndrome characterized by hyperglycemia because of absolute or relative deficiency of insulin . The diagnosis of dm is based on blood glucose estimations . Blood collection is an invasive procedure, and may be traumatizing, especially in diabetic patients who require routine daily m... |
Due to increasing life expectancy of the dentition, older adults are experiencing root caries and gingival recession, putting them at even higher risk for periodontal disease . Root caries is the major cause of tooth loss in older adults, and tooth loss is the most significant oral health - related negative variable of... |
Overweight and obesity is an increasing problem globally . The prevalence is often estimated by body mass index (bmi; weight in kg divided by squared height in meters). In epidemiological surveys, height and weight are often gathered using self - report questionnaires . This type of data collection is advantageous beca... |
The functions of the salivary glands are controlled by the autonomic nervous system and influenced by the sensory nervous system . When parasympathetic impulses dominate, salivary flow is greatly enhanced and the saliva has a low protein content . Studies of animal and human innervation have revealed that parasympathet... |
The technique of lymphatic mapping and sentinel lymph node biopsy (slnb) has emerged in the last two decades as a minimally invasive approach to evaluate regional lymph node basins in patients with intermediate and high - risk primary cutaneous melanoma . In particular, slnb is now recommended as a staging procedure fo... |
The chronic diseases like cardiovascular diseases, diabetes and cancer contributes to almost half of the all - cause mortality in india . Weighted prevalence of ischemic heart diseases was observed as 25.3/1000 population, and 118.0/1000 population for diabetes mellitus in an urban area of india . It was observed due t... |
Proinflammatory cytokines (il-1, il-6, and tnf-) may significantly influence the development of obesity and concomitant disorders such as type 2 diabetes, arterial hypertension and metabolic disorders . It is suggested, that il-6 may affect the increase of free fatty acids level . Tnf- is secreted mainly by macrophages... |
The empa - reg outcome trial (clinicaltrials.gov identifier, nct01131676) recently announced the effects of empagliflozin on the cardiovascular outcomes (cvo) and mortality in persons with type 2 diabetes mellitus (t2 dm). In this seminal cvo trial (cvot), 7020 patients with t2 dm with coexisting cardiovascular disease... |
Primary neuroendocrine carcinoma (nec) of the breast is a rare distinct clinicopathological entity, comprising 0.5 - 2% of breast carcinomas world - wide . In 2003, primary nec of the breast was identified as a distinct entity by the world health organization (who) classification of tumors . The who classification defi... |
Malignant unilateral or bilateral ureteral obstruction may be secondary to direct tumor invasion, extrinsic compression, or encasement by metastatic retroperitoneal or pelvic lymph nodes . The selection of cancer patients for diversion should take into account factors such as tumor stage, prognosis of the primary cance... |
Typically, using standard assessment criteria, approximately 50 to 100 channel targets are detected in chondrocytes . Not surprisingly the dataset from each study are rather different to each other, but there is a common set of 7 probes that are detected in all 10 of these studies . It is important to note that this an... |
Chronic obstructive pulmonary disease (copd) is characterized by progressive and partially reversible airflow limitation, and it is among the leading causes of mortality worldwide.1 copd is a multicomponent disease, and patients present a range of comorbidities that have an impact on prognosis and may increase the risk... |
Intestinal helminths are among the most common and widespread of human infections, contributing to poor nutritional status, anemia and impaired growth (1). Intestinal helminthiases are also known to aggravate pre - existing anemia by decreasing appetite and thus food and iron intake (2, 3). Worldwide, anemia is an impo... |
Soft tissue sarcomas are very rare tumors; however, there are many histologic subtypes . Among those subtypes, furthermore, among sarcomas originating within the retroperitoneum, which constitute 1015% of all soft tissue sarcomas, liposarcomas are the most common histologic type, accounting for 41% of these tumors [2, ... |
Eight members with schwannomatosis from four consecutive generations of a family included in this study were selected according to the following criteria: age:> 30 years; two or more nonintradermal schwannomas, at least one with histological confirmation; no evidence of vestibular tumor on high - quality magnetic reson... |
Emergence of bacterial resistance to many different antibiotics is considered as a great concern in human health . Pseudomonas aeruginosa (pa) has been recognized as one of the significant pathogens of nosocomial infections (1). Key mechanism of antibiotic resistance in p. aeruginosa is the expulsion of antibiotics thr... |
Severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit (icu) setting . The endotoxin (lipopolysaccharide [lps]) derived from the outer membranes of gram - negative bacteria is considered a major factor in the pathogenesis of sepsis . The toll - like receptor (tlr) family c... |
A recent report published by the american association of colleges of nursing (aacn) noted that over 67,000 qualified applicants were not accepted into baccalaureate and graduate nursing programs in the usa in 2010 . The report also noted that almost two - thirds of the nursing schools participating in the survey noted ... |
Ameloblastoma is seen to have a benign appearance on histology, irrespective of its variable clinical behavior . Microscopically various patterns have been described (follicular, plexiform, acanthomatous, papilliferous - keratotic, granular cell type, desmoplastic, vascular, and dentinoameloblastoma). [13] majority of ... |
Mesenteric and omental mesothelial cysts are responsible for only 1 in 100,000 of adult hospital admissions, and are thus left low on the list of differential diagnoses for abdominal pain . Further evaluation of such masses is first directed at determining a tissue origin if possible . Lymphangioma accounts for the mos... |
In the past, a number of studies1,2 have given insight into the epidemiology of primary open - angle glaucoma . For caucasians, it is estimated that almost 2% of the population will suffer from the disease, and for afro - caribbeans this percentage goes to almost 8% . According to the world health organization, age - r... |
In the united states, 166 million dental restorations were placed in 2005,1 and clinical studies suggest that more than half were replacements for failed restorations.2 it is anticipated that the emphasis on replacement therapy will increase with the phasing out of dental amalgam . Global concerns regarding mercury in ... |
Sarcoidosis is a rare condition with a prevalence of 4.46.3 patients per 100,000 personyears in australia, a figure similar to that of the united state 1, 2 . It is a multisystem granulomatous disorder of unknown etiology predominantly affecting young and middleaged adults 3, 4 . Diagnostic criteria are based on a comp... |
Apratoxins are potent cytotoxins derived from marine cyanobacteria . Because of their biological activity and intriguing structures, we recently established that apratoxins prevent cotranslational translocation and thereby downregulate various receptors, including receptor tyrosine kinases (rtks), and inhibit trafficki... |
Seizure in patients with systemic lupus erythematosus (sle) is considered to be one of the major manifestations of the disease . The prevalence of seizure has been documented as about 10 to 20% in the patients with sle (1, 2). This neuropsychiatric event is likely to be primary to the sle or secondary due to other conc... |
Stress urinary incontinence (sui), pelvic organ prolapse, and chronic pelvic pain are frequent complaints of women in perimenopause and menopause and result mainly from pelvic floor insufficiency . Proper statics of the pelvic floor provides adequate support for the urethra and bladder, which determines the correct mec... |
Thermal spring's microbiomes have been in attention of the scientific community since past few decades . These springs, being hub of diverse microflora, increase the probability of vast gene pool of uncultured microbiota . Metagenomics have helped the microbiologist to reveal the genome of the rest of the 99% of non - ... |
An article recently published demonstrated the efficacy of eculizumab in the treatment of children with severe hematopoietic stem cell transplantation - associated thrombotic micro - angiopathy (hsct - tma). We report the case of an adult with hsct - tma successfully treated with eculizumab . Hsct - tma is a rare but v... |
Numerous medical conditions are known to produce psychotic symptoms that resemble schizophrenia, including metabolic and neurological disorders (cummings 1996). We describe a young woman with schizophrenia - like psychotic symptoms and functional decline in the context of diagnosed aceruloplasminemia, a disorder which ... |
We screened a collection of sponge- and marine fungi - derived extracts (n = 2500) and pure compounds (n = 400) using a primary cell - based in vitro model of hiv-1 latency that is re - engineered for optimal sensitivity and miniaturized for high - throughput screening . Two hits were initially given high priority for ... |
Warfarin is highly effective in reducing stroke risk in patients with atrial fibrillation (af). However, using warfarin is not easy; effort is needed to educate patients about drug and dietary interactions, and serial monitoring of the international normalization ratio (inr) is required . As a result, a recent populati... |
The author has not received any funding or benefits from industry or elsewhere to conduct this study. |
Attention to women's health has evolved from a limited focus on reproductive and breast health to encompassing all aspects of health from birth through old age . In the era of individualized and precision medicine, innovative medical, surgical, pharmacological, regenerative, and genetic technologies are available to im... |
Thymic neuroendocrine (ne) tumors associated with multiple endocrine neoplasia type 1 (men-1) are rare, variably documented in 1 - 8% cases . Thymic ne tumors are usually detected about 7 - 29 years following surgical treatment of primary hyperparathyroidism (phpt) in men-1 . Transcervical thymectomy (tct) at the time ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.