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There is evidence corroborating the relationship of vascular dysfunction during the first decade of life with risk factors such as familial hypercholesterolemia and hypertension . However, the question whether or not people exposed to cigarette smoke also develop these dysfunctions remains controversial . Numerous stud...
The present analysis was performed as part of the diabetes and informatics (dai) study, a multicenter cohort study conducted by the dai study group (diainf) together with the italian association of clinical diabetologists (amd) and the italian national institute of health (iss) since september 1998 . The aim of the dai...
Electrophysiological brain signals are widely studied to get insights into the inner function of the brain . The electro - encephalogram (eeg), as an example, has been analyzed for decades and is particularly popular because of its noninvasiveness, wide availability, relatively small cost and excellent temporal resolut...
Written informed consent was obtained from the patient for publication of this case report and accompanying images . A copy of the written consent is available for review by the editor - in - chief of this journal on request . Lumbar hernias are rare and good history and general physical examination can rule out most o...
Gastroesophageal reflux disease (gerd) is one of the most frequently occurring benign functional disorders in western industrial countries . The effectiveness of laparoscopic antireflux surgery for recalcitrant gerd has been clearly demonstrated in several series . These laparoscopic results, in combination with a shor...
Acute epidural hematoma (edh) accounts for 2.7% to 11% of traumatic brain injuries (tbis), and if the size is large, the disease leads to devastating results.1712) generally, a small edh does not cause neurological deficits, and it has a good prognosis . However, if an initially small edh suddenly expands, the patient'...
Duodeno - duodenal intussusception, which involves the distal invagination of a segment of the duodenum, is a rare condition owing to the retroperitoneal fixation of the duodenum, which is sometime absent in cases of intestinal malrotation . The vast majority (8090%) of cases of intestinal intussusception are secondary...
It is characterized by autoantibodies that target against liver - specific and non - organ - specific antigens (1). Corticosteroids, especially prednisone or prednisolone (pd), have been the key drugs of initial antiinflammatory and immuno - suppressive therapy of autoimmune hepatitis in children (2). However, it is we...
Congenital mitral valve anomalies are very rare clinical entities involving one or more components of the mitral valve apparatus . The majority of these abnormalities are causing mitral valve insufficiency and commonly presenting in the early part of life . Common clinical presentations include left ventricular outflow...
Nontraumatic spontaneous intracranial hemorrhage (ich) causes significant morbidity and mortality throughout the world . Ten to 20% of strokes are caused by ich in western countries.6) over 45 years of age, ich is common,5)16)21) but rare before then . Therefore, the goal of our study was to perform a descriptive analy...
Given that almost three quarters of older adults lack decision - making capacity when urgent choices about life - sustaining treatment need to be made, older adults have long been encouraged by nurses and other health care providers to express their wishes for health care while they are healthy enough to meaningfully p...
Lung cancer is the leading cause of cancer death in most countries . Although much effort has been made over the last few decades to improve the survival of lung cancer patients, overall five - year survival rates remain unsatisfactorily low (14% in the u.s.a .) Brain metastasis (bm) is a major cause of the low surviva...
Hyponatraemia is the most commonly encountered electrolyte abnormality in hospitalised patients particularly in the intensive care unit (icu). In a post - surgical icu, the syndrome of inappropriate secretion of antidiuretic hormone (siadh) is a frequent cause for hyponatraemia . Vaptans, a new group of vasopressin rec...
The introduction and subsequent sustained global spread in the human population of influenza a viruses with a novel hemagglutinin (ha) subtype leads to an influenza pandemic . The novel influenza pandemics that occurred during the last century resulted in considerable mortality and morbidity . Genetic investigations re...
Using best evidence to inform healthcare decisions is widely recognized as a key competency for all healthcare professionals . Academic institutions are implementing evidence - based healthcare (ebhc) as part of learning in the curriculum of healthcare professionals . These curricula usually cover critical enquiry and ...
The regulated expression of different families of retrotransposons and dna transposons has been described in different tissues and species . However, a detailed analysis of the transcripts or their temporal and spatial expression patterns has been reported in only a few cases . During drosophila embryogenesis, spatial ...
We obtained formalin - fixed, paraffin - embedded tissue sections from 30 leiomyosarcoma patients at the university of texas md anderson cancer center (mdacc; houston, texas, usa). These included samples from the retroperitoneum (n = 12), gastrointestinal tract (n = 9), uterus (n = 6), and skin (n = 3). To validate the...
Child abuse is defined as any physical or emotional injury which causes harm or substantive risk of harm to the child's health or welfare . It includes sexual abuse, neglect, or being physically dependent upon an addictive drug at birth . Types of child abuse, include physical abuse, emotional abuse and neglect, health...
Oncocytes are observed in lesions of several organs such as the thyroid, kidney, pancreas, ovary, liver, and salivary gland . In the salivary glands, oncocytes are known to arise in warthin tumor, oncocytoma, oncocytic carcinoma, and oncocytosis . Oncocytosis is a rare non - neoplastic lesion that is classified as diff...
A 59 year - old female with a family history of mcd presented to our clinic with progressive loss of vision over a 40-year period . There were multiple irregular grayish - white, dense, poorly delineated spots in the stroma . Because her parents died at an early age, her family history was unclear . Of note, her only s...
Various methods including chemical, electro - chemical, and physical deposition techniques have been employed to synthesize 1d zno nanostructures [3 - 5]. On the other hand, the wet - chemical methods [6 - 8] have been used for producing varied zno one - dimensional (1d) nanostructures, such as nanotube, nanopencil, na...
The adverse consequences of the acquired immune deficiency syndrome (aids) or t cell immunodeficiency provide evidence of the vital role of cytotoxic t - lymphocytes (ctl) in the immune response . Indeed, ctl are well - known elements of the immune response to virus - infected, tumour and allogeneic cells [13]. More re...
Skin tissue integrity is a crucial factor to maintain the homeostasis generated through physical barriers, separating the organism from the environment . Every disruption of dermal integrity triggers a complicated cascade of events, including rapid blood clot formation, inflammatory response, and wound healing, leading...
Acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection occurring mostly in intensive care units.1 members of genus acinetobacter is gram negative, nonmotile nonspore forming encapsulated coccobacilli belonging to family neisseriaceae.2 it is an opportunistic pathogen ...
Bone grafting is common in neurosurgery for spinal fusion and in orthopedic reconstruction surgery for revision hip replacement, repairing skeletal defects after a trauma, and for support when removing a tumor . Three types of bone graft are used: autograft (autologous graft), allograft, and alloplastic graft . An allo...
Globally, mother - to - child transmission of hiv-1 results in approximately 370 000 infant infections each year . Hiv-1 early infant diagnosis (eid) programs aims to detect hiv infection as early as possible in hiv - exposed infant and to link them to care and treatment . Eid of hiv confers substantial benefits to inf...
Regulation of gene expression is fundamental for the coordinate synthesis, assembly and localization of the macromolecular structures of cells . This is achieved by a multi - step program that is highly interconnected and regulated at diverse levels (fig . It starts in the nucleus, where transcription factors bind to s...
Fetus in fetu (fif) was first described by meckel in the early 19th century, and it was defined as a mass containing a vertebral axis often associated with other organs or limbs around this central axis in 19351). Since then, this disease entity has been rarely reported . With advance in prenatal diagnosis techniques, ...
During october 1, 2010july 31, 2011, the centers for disease control and prevention (cdc; atlanta, georgia, usa) asked all state public health laboratories to submit pandemic (h1n1) 2009 virus positive respiratory specimens and virus isolates for antiviral susceptibility testing . Laboratories were asked to provide the...
The incidence of cutaneous melanoma (cm) is rapidly increasing in europe, especially in the caucasian population . Incidences are known to vary amongst white populations, reaching 15 cases per 100,000 inhabitants per year in scandinavia and 57 cases per 100,000 inhabitants per year in mediterranean countries [24]. Fort...
Head and neck squamous cell carcinoma (hnscc) is one of the most prevalent and lethal cancers worldwide (argiris et al ., 2008). Despite recent advances in early detection, surgical techniques, radiation and chemotherapeutic regimes (temam et al . 2009), the survival rate and quality of life for patients with hnscc has...
Crohn's disease (cd) is a form of inflammatory bowel disease (ibd) affecting the entire gastrointestinal (gi) tract [14]. Cd is characterized by transmural inflammation of gi wall in a noncontiguous pattern anywhere from the mouth to the anus [5, 6]. It is believed that, in genetically predisposed individuals, interact...
Contaminated sites are extensively present in europe where approximately 250,000 sites require cleanup interventions, as listed by the european environment agency . Several thousands of these sites are located in italy, and a total of 57 sites, defined in 2009 as national priority contaminated sites (npcss), qualify fo...
Simultaneous bipolar dislocation of the clavicle is uncommon and unusual, although it has been documented as panclavicular dislocation, floating clavicle, and complete dislocation of the clavicle . A review of the recent literature indicated that most bipolar clavicular dislocations have been treated non - operatively ...
Neural stem cells (nscs) are multipotent cells that can give rise to various cell types in the central nervous system (cns), including neurons, astrocytes, and oligodendrocytes (alvarez - buylla et al ., 2002). In adult mammals, neurogenesis is limited to two brain regions; the subventricular zone (svz) by the lateral ...
Torus hyperplasia is a very rare condition also known as focal pyloric hypertrophy (1). This lesion is caused by a circular muscle hypertrophy affecting the lesser curvature near the pylorus . Pathogenesis of the lesion is unclear, some considering it as a persistence of infantile pyloric hypertrophy to adulthood, othe...
The incidence of non - hodgkin lymphoma (nhl) is rising worldwide and is higher in developed countries than in africa and asia . B cell non - hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis c virus (hcv) infection . The prevalence of hcv infection in patients with b cell no...
We studied 22 samples, from dogs, cattle, wildlife, and humans in cear, obtained from 1997 to 2003 (table). Samples were antigenically characterized by using a monoclonal antibody (mab) panel against the viral nucleoprotein (35). Isolates were injected into the brains of suckling mice, and brain impressions were made f...
Toxoplasma gondii (t. gondii) is an obligate intracellular protozoan parasite that causes toxoplasmosis, a usually asymptomatic disease in most immune - competent individuals but potentially severe in immune - compromised hosts . Successful control of this pathogen depends on the early production of the proinflammatory...
Implantation always involves penetration to the skin and damage of smaller or larger blood vessels through the surgical procedure and the implanted scaffold material will have direct contact with human blood . Scaffolds as medical implants require assessment of hemocompatibility to predict potential procoagulation or i...
The purpose of this study was to investigate the efficacy and safety of fixed dose combination (fdc) of olanzapine 5 mg and fluoxetine 20 mg in indian patients with severe or treatment resistant depression . This was an open, non - comparative study of seven weeks duration with an initial placebo run in period of one w...
For ensuring post - endodontic restorations which provide tooth function and form with adequate force distribution, placement of fiber posts to the root canal are used commonly.1 moreover, the placement of a post is often needed for the restoration of a root canal treated tooth in order to support the core material.2,3...
Pediatric soft - tissue sarcomas (stss) account for approximately 7% of all childhood tumors . Out though surgery is the mainstay of treatment, advent of neoadjuvant chemotherapy (nact) has reduced the incidence of recurrence / metastasis . We present a case of ifs with early and unusual distant metastasis, localized o...
We studied 1,297 patients with type 1 diabetes from the nationwide finnish diabetic nephropathy study (finndiane). Patients were required to have an onset of diabetes before 35 years of age and initiation of permanent insulin treatment within 1 year of diagnosis . Patients were classified into four groups based on the ...
Gwas2 included 450 unrelated generalized vitiligo patients (cases) of non - hispanic / latino european ancestry (eur) from north america and europe, who met strict clinical criteria for generalized vitiligo . Controls for gwas2 were 3182 eur individuals not specifically known to have any autoimmune disease or malignant...
Now they need more attention because as the average life expectancy, elderly population, and subsequent resulting osteoporosis continue to increase, orthopaedic surgeons will get more such cases [14]. Intertrochanteric fractures in the elderly are associated with high rates of mortality, ranging from 15 to 20%, as they...
Nucleic acids are highly attractive class of therapeutics due to their potential to regulate any selected gene of interest . Given their capacity to modulate conventionally undruggable targets, oligonucleotides (ons) have been extensively investigated as potential therapeutics to treat cancer, viral infections, genetic...
Increasing numbers of aesthetic procedures - especially cosmetic nonsurgical injection procedures - are performed every year (1). These procedures are generally safe, although cosmetic facial filler injections could lead to devastating complications such as blindness . There are several reports (most of which were case...
With the ever increasing importance of clinical effectiveness, audit and quality assurance; it is becoming mandatory to grade one's own treatment results . The idea of individuals grading their own performance is a self - teaching exercise and improves the quality of future treatment . The assessment of orthodontic tre...
The motility of nk cells in tissue or tumor microenvironment is likely driven by chemotactic signaling resulting in an approximation to key sites of interest, although nk cell motility in tumors is also driven by the expression of nkg2d ligands . Therefore, similar to a t - cell sampling dendritic cells, nk cells under...
Appropriate timing of treatment is the key to successful intensive care; treatment that is delayed could be as detrimental as treatment that is premature . Therefore, lange and colleagues, in this issue of critical care, reported on the time course of the expression of the different isoforms of the nitric oxide synthas...
Steroid hormones have been traditionally associated with regulation of peripheral organs, associated with stress (corticosterone) or with gonadal function (estrogen and androgens). Over the years, it became evident that these hormones also act within the hypothalamus, in a feedback regulatory loop, to affect the releas...
Primary amenorrhea is the absence of menstruation and secondary sexual characteristics in phenotypic women aged 14 years or older . Common hormonal cause of primary amenorrhea includes pituitary dysfunction, chronic systemic disease, and absent ovarian function . Gonadal failure in genetically xx individuals is ovarian...
We report the case of a 13yearold boy with neuromuscular proximal thoracic scoliosis who was found to have significant torsion of the left main bronchus during general anesthesia for posterior instrumented spinal fusion of t2 to l4 . This patient had a background history of multicore myopathy, which resulted in progres...
Portal hypertension, always accompanies by cirrhosis, can lead to lots of complications including varices hemorrhage, ascites, hypersplenism and hepatic encephalopathy . The risk of varices bleeding in patients with portal hypertension was approximately 30% over 2 years . Nowadays, the treatment for patients with varic...
The frequency of prenatal hydronephrosis diagnosed by ultrasound has been reported to be 0.65.4% of newborns [39]. Among infants with hydronephrosis, hydronephrosis has been reported to be transient or physiological in nature (4188%) or secondary to pelviureteric junction obstruction (1030%), vesicoureteric reflux (102...
D - penicillamine has been known as one of the agents that are able to induce pemphigus (1,2). N-(2-mercapto-2-methylpropionyl)-l - cysteine] is a thiol compound contained two free sulfhydryl groups, whereas d - penicillamine has only one sulfhydryl radical (3). While drug - induced pemphigus was not infrequently demon...
The - and -lactam scaffolds are found in various biologically relevant compounds . Additionally, these core structures are crucial intermediates in the synthesis of various natural products as well as pharmaceuticals, prompting the development of new methods for the synthesis of these valuable structures . Our group ha...
Almost 40%60% of patients with colorectal cancer (crc) develop metastasis, predominantly in the liver . Tumor angiogenesis has been implicated as a major factor in the development and spread of these metastases . The recent discovery of vascular endothelial growth factor - c (vegf - c) and vegf receptor-3 (vegfr-3) inv...
Carotid blow - out syndrome is the most feared complication in head and neck surgery . The syndrome occurs in 3% to 4% of all head and neck cancer patients and is easy to happen following fistula formation, bad wound healing and tumor recurrence . Carotid blow - out syndrome presents an average of 2.7 years after the i...
Errors in the health care system are due to a diverse interaction of human behavior, socio - cultural aspects, technical aspects of the system, as well as a range of system weaknesses . Various categories of errors present as an overlap between human and system causes . When working conditions lead to circumstances in ...
Sulfonamides and sulfones serve both as useful intermediates in organic synthesis and as important target molecules in their own right . For example, enantioenriched secondary benzylic sulfonamides and sulfones display a range of biological activity (e.g., protein tyrosine phosphatase inhibitor, antisepsis agent, and -...
Gold nanorods (gnrs) are anisotropic particles whose surface plasmon modes can be tuned as a function of aspect ratio, with optical resonances ranging from visible to near - infrared wavelengths . Gnrs have been investigated as contrast agents for optical biomedical imaging modalities such as optical coherence tomograp...
Are commonly used on the other hand an opioid consumption is traditionally common in iran . The effects of different addictives on body systems have been reported; however, there is not enough information about different blood parameters (2). The effect of some psychoactive substances on commonly observed diseases like...
Research interest is increasing in biomaterials with the potential to stimulate bone healing have gained interest to improve treatment outcome for patients with osteoporotic fractures . Calcium phosphate cements (cpc) has been used in bone surgery for many years . The bio - inspired combination of the inorganic compone...
M. tuberculosis isolates were obtained from the laboratory of mycobacteriology of the institut pasteur de tunis as part of the national tuberculosis surveillance program . All samples (884 specimens) from patients with suspected tb residing in northern tunisia (bizerte) from august 2001 to october 2003 were forwarded t...
The goals of surgical management include correction and maintenance of sagittal and coronal alignment, establishment of length and rotation, and early functional range of movements of knee and ankle . Interlocking nailing of tibial fractures is desirable because this technique allows some load sharing, spares extra oss...
This was a retrospective study that included consecutive cases undergoing surgery for primary rhegmatogenous rd in patients with pseudophakia after phacoemulsification between the dates of january 2000 and june 2008 that had a follow - up duration of at least 12 months . Eyes were excluded from the study if they had no...
The patient was an 11-year - old boy with no family history of optic neuropathy or dystonia . He presented with focal dystonia in the right upper limb at 3 years of age, and his disease progressed over 4 years to dystonia in both the upper and the lower limbs on his dominant right side . At 5 years of age however, at 7...
Fibrous dysplasia of bone is characterized by the replacement of medullary bone with fibro - osseous tissue . This results in the distortion and overgrowth of bone, leading to characteristic deformities . Based on the bony involvement, fibrous dysplasia is divided into three types: monostotic, polyostotic, and mccune a...
Pseudouridine () is the most abundant post - transcriptional rna base modification and the enzymes responsible for this isomerization of uridine and the positions modified in the rnas, are conserved (14). This modification is important in the structure and function of small rnas (511), including small nuclear rnas (snr...
Midfacial defects are classified as midline midfacial defects, that include the nose and/or upper lip; and lateral defects, which include the orbital contents and cheek . Facial prosthesis is generally considered over surgical reconstruction to restore function and appearance in patients with facial defects that result...
The incidence of well - differentiated thyroid carcinoma, particularly papillary cancer, has been increasing since the last 2030 years . The surveillance, epidemiology and end results (seer) database shows more than a 2-fold increase in thyroid cancer since 1995 . An important contributing factor for the increased inci...
Misdiagnosis of bipolar disorder is a potentially serious problem for patients, which sometimes leads to inappropriate treatment.1 however, it is not unusual for bipolar disorder to be misdiagnosed as a major depressive disorder.2 previous studies have shown that the proportion of cases of bipolar disorder misdiagnosed...
Chronic subdural hematoma (csdh) is a rare complication of unruptured aneurysm clipping surgery5,12). Because csdh signs and symptoms may appear slowly, it can cause problems such as headache, dizziness, seizure, and hemiparesis, and requires surgical drainage . Mori et al.11) reported severe complications of surgical ...
Helicobacter pylori have infected nearly half of the world s population . In the developing countries, more than 90% of adults are typically infected during their early childhood, and once acquired the infection would last for several decades (1). Helicobacter pylori infection is the main cause of gastritis and persist...
Tuberous sclerosis complex (tsc) is a genetic disorder that can affect almost all organ systems . Renal manifestations occur with high frequency, the most prevalent being angiomyolipoma (aml). Tsc - associated amls tend to be larger, more numerous, and more likely to cause spontaneous hemorrhage compared with sporadic ...
The diagnosis of unexplained syncopal episodes and sustained palpitations remains a difficult task in clinical cardiology . Standard 24 h holter monitoring has a low diagnostic yield, while implantable loop recorder (ilr) has a higher diagnostic yield, but it is expensive and mildly invasive, making its role in diagnos...
Conflict of interest: jjf is a consultant for nkt therapeutics and receives research funding from nkt therapeutics and astellas . Red cell transfusions are frequently used to treat severe anemia and to reduce the effects of sickle cells . Unlike many patient populations, patients with scd have a much higher risk of adv...
The vertebral fractures is the most common complications of osteoporosis.13) these fractures result in significant mortality and morbidity including prolonged and intractable pain.4,13) percutaneous vertebroplasty, a therapeutic procedure for filling the collapsed vertebral body with polymethylmethacrylate, provides pa...
Stridor in children is usually due to airway pathology but neurological conditions causing stridor are not infrequent . In cases with an underlying neurological pathology causing stridor, the treatment of the underlying cause usually relieves the stridor . We report the association of stridor in a child presenting with...
The success of dental implant is primarily based on good osseointegration, which depends on the biocompatibility of the implant material and implant surface properties, as well as on the quantity and quality of remaining tissue.1 commercially pure titanium and titanium alloys are traditional materials used in most comm...
These techniques have helped surgeons adequately manage complex trauma, tumor, and degenerative pathologies . Hadra in 1890 described the use of wiring and graft techniques to perform the first spinal fusion procedures . These techniques were standard until the start of modern cervical spinal fusion with roy - camille ...
Biological variation allows for a unique craniofacial character and many asymmetries found in each individual . A neurodevelopmental disorder has been defined as an impairment of the growth and development of the brain or central nervous system . A narrower use of the term refers to a disorder of the brain function tha...
The verbal informed patient consent was acquired for the case report publication during the acute rehabilitation . Institutional review board approval was not sought for this case report . Whether a patient visits a clinic or is admitted to the hospital, the importance of a detailed physical examination must be emphasi...
Higher energy intake than expenditure causes excessive accumulation of fat and leads to the development of obesity and associated metabolic disorders, which has reached epidemic proportions not only in developed countries but worldwide . Furthermore, obesity can lead to the development of various co - morbidities, like...
We report herein a modification of existing techniques to enable a small anterior resection to be done without having to open either the abdomen or the rectal lumen . The patient was a 28-year - old woman with a 10-year history of pelvic pain . The most recent had suggested tethering of the rectum to the back of the ce...
Thymic carcinoma is an aggressive anterior mediastinal malignancy that can cause severe chest pain, although its incidence is rare . Echocardiography is useful for assessing chest pain in the emergency room, but the diagnosis of an extracardiac mass can be missed . The purpose of this report is to describe the validati...
Bromodomains are epigenetic readers that specifically recognize acetyl - lysine (kac) marks on proteins . Targeting this protein interaction module with small molecules has recently emerged as a potential therapeutic strategy for the treatment of several diseases including cancer and inflammation . To date, most inhibi...
Every human voice is unique as it was found to be quantitatively composed of components called phonemes that have a pitch, cadence, and inflection . Hence human voice has been used as one of the popular biometrics in biosecurity applications; it can be used to authenticate a person's identity (identification) and contr...
Medical doctors move across borders being motivated by higher salaries, better working conditions, new professional experience, and training and career opportunities . In europe, migration of medical doctors has been observed since the 1940s and has shown various dynamics over the years . European integration has offer...
Imipramine was found to improve mood while being used in a protocol to search for an antipsychotic:' iproniazid, a drug used in the treatment of tuberculosis, was likewise found to have beneficial effects on mood . The former, a tricyclic antidepressant (tca), and the latter, a monoamine oxidase inhibitor (maoi), belon...
Africa, the population size of the city of tshwane in 2011 was roughly equal to 3 million . The city is home to over 5,000 businesses out of which 1,603 businesses operate within the central business district of tshwane, known as pretoria . According to the annual report issued by the city of tshwane metropolitan munic...
Parkinson's disease (pd) is a neurodegenerative condition characterised clinically as a movement disorder consisting of bradykinesia, rigidity and rest tremor, as a consequence of striatal dopamine depletion secondary to degeneration of the dopaminergic neurons of the substantia nigra . In addition, pathology in other ...
Panoramic radiography is a cost - effective, low - dose method used in dental radiology for evaluating oral health status in routine dental practice.1 this technique allows examination of the maxillary and mandibular arches and their supporting structures on a single image.23 the advantages of panoramic radiography are...
Spinal epidural lipomatosis (sel) is a rare disease that is characterized by pathologic overgrowth of lumbar or thoracic epidural fat tissue . Although the etiology of sel is not known, sel has been frequently diagnosed in obese patient groups and exogenous steroid administration groups, so steroid metabolism is presum...
Increased long - term survival following effective treatment of childhood lymphomas has placed greater emphasis on residual sequelae of therapy for lymphoma and the impact of these sequelae as the cause of further morbidity and mortality . Following treatment of childhood hodgkin's disease, cardiac pathology is second ...