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Cerebellar ataxia is a frequent and often - disabling syndrome that is mainly characterized by limb and gait ataxia as well as speech and ocular function impairment . In the majority of cases so far, treatment of cerebellar ataxia has remained a difficult task as no medication has yet been proven really effective . The...
There had been no pain or dysphonia but a bothersome sensation related to progressive surface roughness that prompted her to seek care . She was otherwise healthy; a small congenital melanocytic nevus affecting the right inner thigh had been excised during early childhood . On examination, there was no palpable cervica...
The production of nano- and microfibers has gained increasing interest due to the large number of promising applications, including filtration, textiles, medical, protective, structural, electrical, and optical materials and coatings . In particular, an intriguing feature of electrospun fibers is the high surface - are...
Cataract development is one of the major causes of visual impairment and eventual blindness.1,2 while cataract surgery has the potential of decreasing blindness due to this disease, the problem is so huge that it is difficult to eliminate it to the desired level, even by 2020 . In fact, despite enhancement of surgical ...
We describe the first documented case of gallbladder agenesis where the clinical presentation was consistent with biliary colic, and radiological investigation suggested the presence of gallstones within a collapsed, fibrosed gallbladder . Subsequent operative findings revealed a solitary haemangioma of the liver sited...
Despite contemporary evidence - based care, including revascularization and dual antiplatelet therapy, patients with acute coronary syndromes (acss) remain at risk of recurrent ischaemic events . Oral vitamin k antagonists have been shown to prevent recurrent ischaemic events after acs, both as mono - therapy and in co...
Agitation, referring to a syndrome involving emotional distress, excessive psychomotor activity, aggression, irritability, disinhibition, and/or vocal disruptive behaviors unexplained by apparent needs, or confusion,1,2 is a very common phenomenon in the course of dementia.35 it can afflict patients at any level of dem...
During 20052010 (time span needed to cover the study area) and during the months more favorable for infection (october april), foxes were either shot at night or trapped . Therefore, a grid of 5 km 5 km to 10 km 10 km, depending on the department size, was superimposed over the sampling area, and no more than 1 fox was...
The most recent 2009 usrds report observed high first- and second - month death rates after hd initiation . The choice study reported 50% higher mortality rates in patients initiating hd with a tc as compared to patients with an avf . There was a trend toward higher mortality rates (21% increased) in incident hd patien...
With the increased incidence of chronic renal failure, radiocontrast studies are important for diagnosis and treatment . Therefore, the use of iodinated radiocontrast media in computed tomography (ct) and angiography is often required in these patients [13]. The european society for urogenital radiology guidelines, whi...
Traumatic brain injury (tbi) caused by motor vehicle accidents, firearms, and falls are recorded as a leading cause of death and lifelong disability among young adults. [14] the glasgow coma scale (gcs) has been extensively studied for its ability to predict outcomes in tbi patients . Representative tbis that could ind...
The subversionary thoughts of many researchers in the field of implants have resulted in an unprecedented rise of several implant surfaces and research . The osteoblastic cell behavior acts as a yardstick to assess the success of such surfaces . The quest for better osseointegration has not only fuelled the demand of m...
Recently, endoscopic papillotomy (e.p.t .) Has achieved wide acceptance as an alternative to surgery for the management of choledocholithiasis . However, there are several of problems, one of which relates to the size of the stone . A stone larger than 2.5 cm in diameter has been regarded as a contraindication of endos...
Massively parallel sequencing, also called next - generation sequencing, has dramatically lowered the cost of genomic sequencing for multiple genetic conditions . Best ethical and clinical practice for clinical diagnostic testing using traditional targeted sequencing technologies requires obtaining informed consent and...
Personality disorders are made up of a group of psychiatric disorders that all share a common feature of an enduring, maladaptive behavior pattern markedly deviating from social expectations . Personality disorders are often diagnosed in early adulthood, and though some symptoms can be mitigated, they last a lifetime ....
The differential diagnosis of predominant plasmacytoid cells on thyroid fine - needle aspirates should also include ptl with extensive plasmacytic differentiation, besides plasmacytoma . Further studies are required to assess plasmacytic differentiation in various thyroid lymphomas so as to differentiate them from plas...
Partial sacrectomy is usually performed when a sacral tumor involves high - level sacral vertebra . Traditionally, surgical treatment without reconstruction often damaged the sacroiliac joint and the ligaments around it, and was often associated with prolonged immobilization during the recovery phase . Thus, lumbosacra...
Laparoscopic surgery provides a higher degree of patient satisfaction than does open surgery from a cosmetic perspective, and it is also effective in reducing postoperative pain, operative wound complications, blood loss, and the length of hospital stay . Accordingly, it has been remarkably developed in the field of ur...
Nonscalpel vasectomy (nsv) is a modified and sophisticated technique of vasectomy that requires no incision but only a small puncture and no stitches . This is a safe and simple procedure that can be performed in low - resource settings . Nsv technique was introduced in india in 1992 to increase male participation in f...
With the proliferation of cross - sectional imaging, detection of an incidental adrenal mass has become a common problem . Adrenal incidentalomas are detected on approximately 5 to 8% of all high - resolution abdominal imaging studies . The diagnostic strategy is well established for adrenal adenomas and relies on the ...
Classical (pre-1950) biophysics (reviewed in gratzer, 2011; pederson, 2014) did not worry much about differences between nucleus and cytoplasm, mainly because the focus of physiology was on the latter compartment (needham, 1971) and in particular on actomyosin function (hanson and huxley, 1953). Francis crick studied t...
It occurs in 0.4% to 2% of patients with ibd, with a slightly higher prevalence in patients with uc than in those with cd.12 approximately 36% to 50% of patients with pg have underlying ibd.2 the correlation between clinical activity of the intestinal disease and the appearance of skin lesions is controversial . As thi...
Medical education aims to prepare medical students for clinical practice . Educational environment is the most important factor effecting on students training and achievements (1 - 3). Therefore, evaluating the educational setting can show defects in medical education and help to solve them (4). This study was designed...
Thousands of dental restorations are placed everyday in children by dentists, dental students and ancillary personnel with reasonable clinical background knowledge in the management of dental caries . These restorations are performed at any time and place on the planet earth, yet it is well known that the earth does no...
The 21-day experimental gingivitis model is an established noninvasive model in humans for investigating the induction and resolution of inflammation in response to increasing bacterial accumulation . From its inception in 1965, this model of inflammation has been used to assess how drugs,(3) bioactive compounds in den...
Infertility, a reproductive health condition prevalent among one in every four couples in the developing countries, is a neglected problem . India alone accounts for 30 million couples of infertility of the total 48.5 million globally affected couples . Assisted reproductive technologies (art) such as in vitro fertiliz...
Hamartomas of the head and neck generally, as well as the sinonasal tract specifically, are very rare . Respiratory epithelial adenomatoid hamartoma (reah) and chondro - osseous respiratory epithelial adenomatoid hamartoma (coreah) are examples of hamartomas comprising both epithelial and mesenchymal components . Altho...
Kidney transplantation is the standard of care for many patients with end stage renal disease (esrd), and has been found to be significantly more effective in improving patient quality of life, physical functioning, and psychosocial functioning (1). Since 1988, the prevalence of both dialysis patients and transplant pa...
Each year, 5000 new cases of oropharyngeal cancer are diagnosed in the us, and 8590% of these are confirmed as squamous cell carcinoma (scc). Cervical lymph node status remains the most important prognosticator in head and neck squamous cell carcinoma (hnscc) in the absence of distant metastases, reducing 5-year surviv...
In recent years, use of electrical stimulation instead of acoustical stimulation has made much objective electrophysiological evaluation possible, that is useful for management process in young children before and after cochlear implant . These evaluations have been used for assessment of neuronal survival before cochl...
The online version of this article (doi:10.1007/s13555 - 015 - 0068 - 3) contains supplementary material, which is available to authorized users . Psoriasis is a chronic, immune - mediated, inflammatory, systemic disease with predominant skin and joint manifestations . As such, it has significant implications on physic...
Fd may occur in one bone (monostotic) or multiple bones (polyostotic) and may be associated with other conditions like mccune albright syndrome . Clinical presentation may occur at any age, with the majority of lesions being detected by the age of 30 years . Common sites of skeletal involvement are the long bones, ribs...
5-hydroxytryptamine (5-ht, serotonin) is a common biogenic amine found in both vertebrates and invertebrates as well as in plants [1, 2]. The precursor to 5-ht, tryptophan, is likey important in the early evolution of life and perhaps the early presence of tryptophan is a reason for 5-ht to be potentially the first neu...
Vascular smooth muscle cells (smcs) play a vital role in the formation of mature and contractile intracranial vessel walls through smc proliferation, migration, and differentiation, and in the change in the extracellular matrix (ecm) components17). Accordingly, an abnormal smc production pathway and altered ecm compone...
The methods of the original study from which these data were acquired have been previously published (10). Briefly, 50 nursing homes with> 100 beds in four provinces (ontario, manitoba, alberta, saskatchewan) and four states (minnesota, michigan, north dakota, montana) were enrolled in the study . During a 12-month per...
The group was composed of consecutive patients reporting to the department of endocrinology because of pcos and/or weight excess and of healthy nonhyperandrogenic nonobese volunteers recruited from the staff of hospital universitario ramn y cajal . Women were classified according to their bmi into obese (bmi 30 kg / m,...
Coronary artery disease (cad) is one of the most important causes of left ventricular systolic dysfunction (lvsd) and it is found in approximately 68% of patients with lvsd.1) because left ventricular (lv) function and prognosis can be improved with successful revascularization, differentiation of significant cad from ...
Venous thromboembolism (vte), which includes both deep vein thrombosis (dvt) and pulmonary embolism (pe), is a common complication of critical illness . Critically ill patients harbor many coincident risk factors for dvt, such as the need for surgery, catheters, immobility, and use of sedatives and paralytic agents [3 ...
One of the most interesting properties of the brain is its ability to change in response to experience . This property has been termed plasticity and is involved in the reorganization of cortical maps during development, and in learning and memory processes in the adult animal (for review, see malenka and bear, 2004). ...
Drug - resistant tuberculosis and multidrug - resistant tuberculosis (mdr - tb) in particular represent a major threat to the fight against tuberculosis globally . Mdr - tb is defined as disease caused by strains of mycobacterium tuberculosis resistant to at least isoniazid and rifampicin, the two most powerful first -...
Interface fluid syndrome (ifs) can develop after laser in situ keratomileusis (lasik). If ifs occurs, intraocular pressure (iop) measurements become unreliable . As a result, glaucomatous optic neuropathy progresses, followed by a detectable increase in iop and a rapid decline in visual function . Reports have describe...
The human genome project had made the scientific community and public believe that all biology and medicine would become understandable after the sequencing of the dna . As biology is much more complicated than the structure and function of nucleic acids, the study of living systems has now expanded past genomics based...
Learning disorder is one of the issues that attract a great deal of attention . The term was primarily suggested by samuel kerck in 1963 to describe a group of children who had problems in developing language, speech, reading, and communicative skills . Students suffering from these disorders, without some special help...
The scientific community may view recovery as an outcome defined by its emphasis on symptoms amelioration and ability to function independently . However for the consumer - focused activists and proponents, recovery is a process toward achieving, among other things, empowerment, hope, and respect . In contrast to clini...
Estimate body composition of children is not an easy task, since the relationships between body components during growth are not constant as in adults . Anthropometric - based equations remain an adequate alternative for determining the body composition of pediatric populations in field settings . However, the advent o...
Tobacco is consumed in two forms: the smoked tobacco products, like cigarettes and shisha (water pipe) and the smokeless tobacco (st). Also known as moist snuff or spit tobacco, is held in the mouth between the cheeks and gums instead of being smoked . The dip rests on the inside lining of the mouth usually for a perio...
Anastomotic leakage and protective urinary diversion in pediatric pyeloplasty continue to be a controversial issue among pediatric urologists (1, 2). Some surgeons prefer a tubeless repair, while others use some varied combination of instruments, including an internal ureteral stent, nephrostomy tube, or a nephron - ur...
Injection drug use is the second leading cause of hiv and the leading cause of hepatitis c virus (hcv) infection in california.1 according to california hiv / aids surveillance data, injection drug use accounts for 10.4% of all newly reported aids cases and 19.1% of cases when male injection drug users (idus) who also ...
The aim of therapy is recuperation or increasing life expectancy in patients with cancer . Yet in order to destroy cancerous cells, various treatments including chemotherapy, radiotherapy, immunotherapy and surgery have been used . However, a common feature of malignancy is resistance to radiation and chemotherapy whic...
Dental caries in primary dentition has been mentioned as an important matter in the recent years because it may be predictive of later caries and also special attention is necessary to overcome this problem . The relative influence of each factor differs noticably in individuals and is not completely recognized . Aberr...
Chronic myeloproliferative diseases include essential thrombocythemia (et), polycythemia vera, chronic myelocytic leukemia and myelofibrosis, and cause hemorrhagic and thrombotic symptoms in many organs of the body . Purpura, subcutaneous hemorrhage, ulcer, acral gangrene, livedo symptoms, and erythromelalgia can occur...
The public has wondered why the humidifier disinfectant disaster (hdd) only occurred in south korea (here after korea). The issue of how a demand for humidifier disinfectant (hd) formed in korea, how the product was released, and how it was distributed for over 20 years needs specialized analysis . This study intends t...
Biliary atresia is the most common neonatal cholestatic disorder with a varying incidence of 1:8000 - 1:18000 . The disease is characterized by obliteration or discontinuity of the extrahepatic bile ducts with persistent jaundice in an infant who usually looks well . Most patients with extrahepatic biliary atresia (ehb...
Dna repair processes are indispensable for maintaining the integrity of genetic information in all organisms . Environmental agents such as chemicals, uv light, and ionizing radiation, as well as endogenous metabolic processes involving dna constantly challenge the chemical structure and stability of the genome . Dna l...
Integration of iii v semiconductor devices on silicon substrates would allow the fabrication of high efficiency optoelectronic and photonic devices using the well - established complementary metal oxide semiconductor (cmos) technology . Although of the great technological interest, results in this field are far from be...
Globally, chronic illnesses are the leading cause of mortality (60%), and this is no different in developing countries, particularly in the caribbean[26]. Statistics indicate that 79% of all mortalities are attributable to chronic diseases, and that they are occurring in developing countries such as those in the caribb...
Mohan s diabetes specialities center in chennai city (formerly madras), in southern india, called diabetes electronic medical records, was established at the time of inception of the center in 1991 and has data of> 200,000 diabetic patients registered between 1991 and 2011 . A preliminary analysis of the diabetes elect...
Severe aplastic anemia (saa) is a fatal disease characterized by pancytopenia and hypocellular bone marrow . Bone marrow transplantation is the treatment of choice for young patients who have a human leukocyte antigen (hla) matched sibling donor . Immunosuppressive treatment (ist) with antithymocyte globulin (atg) and ...
The manual determination of cellular differentials in blood, bone marrow, and body fluids (including urine and pleural, peritoneal, and pericardial fluids) is a well - established diagnostic method useful in the evaluation of hematopoiesis, hematopoietic disorders, and infectious diseases . Similar methods are also emp...
Hepatitis b virus- (hbv-) related end stage liver diseases (esld) account for over 80% of orthotopic liver transplantations (olts) in china, and active hbv replicative status prior to olt is present in over 50% of patients . Although hbv graft reinfection and hepatitis b (hb) recurrence have been controlled to an accep...
Among the neonatal seizure syndromes, benign familial neonatal convulsions (bfnc), a rare autosomal dominant epilepsy characterized by unprovoked, generalized convulsions occurring in the first days of life, must be differentiated from non - epileptic paroxysmal events of the newborn and from other etiologies of neonat...
A recent report in critical care demonstrates the types of steps hospitals are taking to address the growing problem of icu capacity constraints . These steps are often necessary, as icu strain leads to serious, real - world problems . For example, both admission delays from the emergency department to the icu and prem...
The nematode abbreviata hastaspicula (spirurida: physalopteridae) occurs predominantly in varanus gouldii lizards, principally in the arid interior of australia . It requires an arthropod intermediate host to complete its life - cycle (mnnig, 1934, alicata, 1937). Distribution of the nematode genus abbreviata is worldw...
As a common head and neck cancer, nasopharyngeal carcinomas are generally either keratinizing or nonkeratinizing squamous cell carcinomas . Primary nasopharyngeal adenocarcinomas (npacs) are rare neoplasms, constituting only 0.38% to 0.48% of all malignant nasopharyngeal neoplasms . Thyroid - like low - grade nasophary...
A 6-year - old girl presented with unilateral hearing loss . At the physical examination, the otologic status and head and neck status were normal . Pure tone audiometry and speech testing showed total deafness of the right side, but normal hearing thresholds in the left side . An examination with brain stem electric r...
Tumor of the follicular infundibulum (tfi) is a rare benign neoplasm providing two distinctive clinical patterns: the solitary and the eruptive form . The clinical presentations resemble many other dermatologic conditions and require histopathological study to make a definite diagnosis . Although the tumor is called a ...
Obturator hernias (ohs) are rare; they represent only 0.051.4% of all abdominal wall hernias . The typical patient with an women are affected nine times more frequently than men, because of broader pelvis with a larger triangular obturator canal opening with a greater transverse diameter, and a history of pregnancy . A...
Humeral head resurfacing was proposed as a treatment for glenohumeral arthrosis in an attempt to preserve the original anatomy and avoid humeral head resection . Preservation of humeral head maintained the native inclination, offset, head shaft angle, and version of humerus [13]. Other advantages include a shorter oper...
Topiramate is a sulfa - derivative antiepileptic drug which is also used for other indications such as migraine, personality disorders, weight loss, neuropathic pain and, recently, essential tremor [1, 2]. The pharmacodynamic picture of this drug generally reflects the modulation of voltage - gated sodium and calcium c...
Over the past two decades, the single most common cause of withdrawal or restriction of a medication that has already entered the market has been prolongation of the qt interval associated with polymorphic ventricular tachycardia or torsades de pointes.1 nine structurally unrelated drugs marketed in the united states f...
To successfully generate organotypic cerebellar cultures use mice between p0-p3 or p8-p12 . For our experiment we used mice in the p8-p12 range because this developmental stage was more appropriate for our study . Prepare the dissection and the culture medium: brain dissection and slice preparation are carried out in l...
The development of new agents targeting important cellular pathways involved in cancer progression, although promising, has so far resulted in relatively short - term benefits for the majority of patients with advanced malignancy . Cell therapy can be numbered among the novel biologic therapeutics that will increase ou...
This study evaluated variables already in the literature, but the breakdown and comparison among different ethnic groups is new and important to understand and be able to address the specific needs of older adults from these groups . We evaluated a convenience sample of ethnically diverse community - dwelling older adu...
A traumatic right diaphragmatic rupture as the result of blunt trauma is a rare condition . The overall incidence of diaphragmatic rupture after blunt trauma is 0.8 - 3.6% (1). Most injuries are due to vehicular - related incidents (79.5%) and falling from a height (15.9%) (2). Right - sided tears are significantly les...
Kaposi's varicelliform eruption (kve), also known as eczema herpeticum, is a rare and potentially fatal viral infection, caused mainly by reactivation of herpes simplex virus (hsv), predominantly type i. other viruses such as coxsackie a 16, vaccinia, and varicella zoster have also been implicated in its pathogenesis ....
Within 4 days, 5 patients with skin lesions suggestive of an opv infection were reported to the infectious disease task force at the bavarian health and food safety authority . Infected patients were from 2 unrelated families living in 2 different counties in the greater munich area, germany . The families had bought 1...
Melanoma diagnosis presents important unmet clinical challenges . On the one hand, the ramatic mismatch between increases in detection and mortality rates (report, 2010) may suggest significant overcalling (glusac, 2011; swerlick and chen, 1996). On the other hand, nearly one in ten patients with thin melanomas (<1 mm)...
Recently, the european hernia society (ehs) has systematised and introduced classifications of inguinal and ventral (primary and incisional) hernias [1, 2]. Both classifications are based on the stipulation that a good classification must be simple; these classifications should mention the most appropriate and practica...
Zimbabwe is in sub - saharan africa which is at the epicenter of the human immune deficiency virus (hiv) epidemic . According to unaids the prevalence of hiv in zimbabwe has decreased to about 1 in 10 adults (2012) from a high one of almost 1 in 4 in 2002 . While the decline is commendable hiv infection still remains a...
A male patient (165 cm in height, 61 kg and 62-year - old) was transferred to our hospital because of the chief complaint of back pain . The back pain had developed approximately 2 months previously without specific trauma, and the area around the left buttock was most painful . The pain worsened while standing up and ...
Cerebral palsy is a clinical syndrome where permanent disorders in development of posture and movement are caused by non - progressive disturbances occurring in the brain of fetus or infant producing activity limitation, and is frequently accompanied by disorders in sensation, cognition, communication, perception, and ...
In 2010, there were an estimated 35.6 million people in the world suffering from dementia . This is an increasing problem; 65.7 million dementia cases are expected by 2030 and 115.4 million by 2050 . This growing problem presents a pressing need for ad treatments . Repetitive transcranial magnetic stimulation (rtms) is...
Trisomy 21 (also referred to as down syndrome) is the most frequent chromosomal abnormality at birth . It affects approximately one in every 800 newborns 1 . In france, prenatal diagnosis is always suggested when indicated by ultrasound findings and maternal serum marker assays . About 92% of cases of down syndrome are...
Sepsis is a major cause of mortality and morbidity and its incidence is increasing . Despite the major social impact of sepsis, inflammation is ubiquitous during the course of critically ill septic patients and may be modulated by several patient's particularities, such as age, gender, and comorbidities [35]. Neverthel...
Previous research has clearly demonstrated that cognitive change in old age does not occur in a homogenous manner for all individuals [13]. A number of predictors of cognitive change in old age have been identified, such as education, hypertension, objective indices of health and cardiovascular disease, and apolipoprot...
The antiepileptic agent phenytoin (pht) has a narrow range of effective blood concentrations and nonlinearity pharmacokinetics . Therefore, the monitoring of its blood concentration (therapeutic drug monitoring, tdm) is essential for ensuring a proper dosage and successful treatment . Because pht is primarily metaboliz...
Levetiracetam [(s)-alpha - ethyl-2-oxo-1-pyrrolidine acetamide] (lev) is a second generation anticonvulsant approved by the european medicines agency (ema) and/or the u.s . Food and drug administration (fda) for the following: 1) monotherapy treatment of partial seizures, with or without secondary generalization (ema);...
Hereditary hemorrhagic telangiectasia (hht), also known as rendu - osler - weber disease, is an autosomal dominant disorder characterized by atriovenous malformations (avms) and telangiectases in multiple organs . The reported incidence of this disease is 1/10000 in north america but it varies between studies.1) the pa...
It is estimated that about india has about 2.09 million cases of people living with human immunodeficiency virus (hiv)/aids in 2011 . Even though the incidence of new cases has reduced over the past few years thus, although the overall hiv adult prevalence in 2011 was 0.27%, in certain high - risk groups the estimated ...
Complex ventricular arrhythmia and death follows overt congestive heart failure (chf), and it is one of the poor prognostic sign of acromegaly . Though prevalence of biventricular hypertrophy present in 90% of autopsied older and 20% of younger patients with acromegaly, presence of overt chf is less common . The estima...
To demonstrate a capsulorhexis technique using predominantly shearing forces with a cystotome on a virtual reality simulator and on a human eye . Our technique involves creating the initial anterior capsular tear with a cystotome to raise a flap . The cystotome tip is tilted horizontally and is engaged on the flap near...
Precise molecular control of protein glycosylation would advance the development of biopharmaceuticals as well as fundamental studies of glycosylation - dependent biological processes . Biological methods on their own have failed to achieve this long sought - after goal, as cellular biosynthetic pathways produce glycop...
Lower - extremity peripheral arterial disease (pad) is estimated to affect between 8 million and 10 million americans . This prevalence is expected to increase, not only in the united states, but across the world as the population ages, cigarette smoking persists, and the epidemic of diabetes mellitus and obesity grows...
The european union (eu) is committed to improving the health of its ageing population, with growing initiatives to promote active and healthy ageing (supplementary figure s1). Its preferred measure is healthy life years (hly), the average remaining years spent free of activity limitation . Health expectancies, of which...
The tongue is an epithelial sac filled with muscles and connective tissue; these muscles can be controlled willfully and are generally referred to as skeletal muscles or voluntary striated muscles, which are divided into intrinsic and extrinsic muscles (brand and isselhard, 2003). In addition, the tongue has various fu...
The differential diagnosis of mediastinal masses includes primary lung cancer, metastatic cancer, neurogenic tumor, cysts and infections.12 the bronchogenic cysts are the most common cystic lesions of the mediastinum.3 in some cases, these lesions could mimic solid masses.4 most patients with posterior mediastinal cyst...