id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
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converted_4165 | Is belimumab effective for the lupus nephritis? | Long-term effects of combined B-cell immunomodulation with rituximab and belimumab in severe, refractory systemic lupus erythematosus: 2-year results., CONCLUSIONS: Combined B-cell targeted therapy with RTX and BLM prevented full B-cell repopulation including DN B cells, with concomitant specific reduction of SLE-relev... | yes |
converted_2476 | Can canagliflozin cause euglycemic diabetic ketoacidosis? | CASE REPORT: We present a case of a 57-year-old woman with type 2 diabetes mellitus taking a combination of canagliflozin and metformin who presented with progressive altered mental status over the previous 2 days. Her work-up demonstrated a metabolic acidosis with an anion gap of 38 and a venous serum pH of 7.08. The ... | yes |
converted_3040 | Is baricitinib effective for rheumatoid arthritis? | CONCLUSION: Baricitinib 2 mg and 4 mg administered once daily, in combination with DMARD, were efficacious interventions for active RA that had no significant risk of TEAE development., CONCLUSIONS: The efficacy and safety profile of baricitinib was maintained during long-term treatment of Japanese patients with RA and... | yes |
converted_4226 | Is phosphoenolpyruvate carboxykinase 1 (PCK1) the rate-limiting enzyme in gluconeogenesis? | Phosphoenolpyruvate carboxykinase (PEPCK) is a metabolic enzyme in the gluconeogenesis pathway,, PEPCK, a key enzyme involved in gluconeogenesis associated with a decrease in the expression of master genes involved in the VLDL synthesis , Transcriptome analysis of rate-limiting enzymes involved in hepatic gluconeogenes... | yes |
converted_4291 | Is histone variant H3.3K27M associated with gliomas? | Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling., Well-known oncohistones, with mutations on both H3.1 and H3.3, include H3K36M in chondroblastoma, H3K27M in glioma, Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children w... | yes |
converted_216 | Are there any DNMT3 proteins present in plants? | De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3., Here we describe DNA methyltransferase genes from both Arabidopsis and maize that show a high level of sequence similarity to Dnmt3, suggesting that they encode plant ... | yes |
converted_3007 | Can mitochondria be inherited by both parents in humans? | Biparental Inheritance of Mitochondrial DNA in Humans., Although there has been considerable debate about whether paternal mitochondrial DNA (mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally believed that mitochondria and mtDNA are exclusively maternally inherited in humans. Here, we... | yes |
converted_480 | Are epigenetic modifications implicated in cardiovascular development and disease? | Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored., The study of epigenetic markers is, therefore, a very promising frontier of scienc... | yes |
converted_1156 | Is armodafinil used for treatment of insomnia? | Other therapies, such as sedative hypnotics, target daytime insomnia, while pharmacologic agents such as modafinil, armodafinil, and caffeine and non-pharmacologic approaches such as napping promote nighttime alertness., Other treatment options may include pharmacologic interventions such as modafinil and armodafinil,... | no |
converted_2665 | Is Lysyl oxidase crosslinking collagen? | Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. , Lysyl oxidase-like 1, a crosslinking enzyme implicated in collagen and elastin biogenesis, LOXL2 mediates collagen crosslinking, The same was true for assaying lysyl ox... | yes |
converted_1502 | Can Alzheimer's disease related miRNAs be detected in patients' blood? | miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD., miRN... | yes |
converted_2111 | Does the TOP2B/TOP2A expression ratio affect the response to AML chemotherapy? | High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia, Genes with distinct expression profiles such as TOP2B/TOP2A expression ratio at diagnosis can be employed for outcome prediction after the treatment with standard regimens in AML patie... | yes |
converted_3444 | Does ProSavin use an adenoviral vector? | Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease., ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolerated in a Phase I/II first-in-human study, with significant improvements in... | no |
converted_308 | Is nucleosome eviction ATP-dependent? | ATP-dependent chromatin remodeling and nucleosome-depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, ATP-dependent nucleosome-remodeling factors endow chromatin with structural flexibility by promoting assembly or disruption of nucleosomes and the exchange of histone variants., remodel... | yes |
converted_2602 | Is Rucaparib effective for ovarian cancer? | INTERPRETATION: In patients with BRCA mutant or BRCA wild-type and LOH high platinum-sensitive ovarian carcinomas treated with rucaparib, progression-free survival was longer than in patients with BRCA wild-type LOH low carcinomas., High LOH is associated with response to the PARP inhibitor rucaparib in BRCA wild-type ... | yes |
converted_790 | Is recommended the use of perioperative treatment with thyroid hormone therapy in patients undergoing coronary artery bypass grafting? | Short duration postoperative iv T(3) therapy increases cardiac index and does not alter mortality., We conclude that although widespread interest has been shown on the use of thyroid hormones in the perioperative period, and the effect of cardiopulmonary bypass on thyroid hormone metabolism widely studied, there is no ... | no |
converted_4053 | Does hypofractionated radiotherapy offers any benefit for DIPG? | CONCLUSION: Hypofractionated RT for children with newly diagnosed DIPG is well tolerated and feasible from the viewpoint of reducing a patient's burden of treatment. Re-irradiation at first progression is suggested to be beneficial., Median OS and time to progression were similar between conventionally fractionated and... | no |
converted_437 | Is there a role for the cylindromatosis tumor suppressor (CYLD) in lung cancer? | Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells, increased expression of CYLD directly blocks TRAIL-induced NF-κB activation, and consequently increases TRAIL-induced apoptosis in lung cancer cells. CYLD may act as a therapeutic target of lung ca... | yes |
converted_1013 | Is farnesoid X receptor (FXR) a nuclear receptor? | Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism, Farnesoid X receptor (FXR) is an ascending target for metabolic and infl... | yes |
converted_3994 | Is there an association of alterations in ADCY7 and ulcerative colitis? | To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population controls across 73.5 million variants. We then imputed from these sequences i... | yes |
converted_4223 | Has the companion diagnostic HercepTest received FDA approval? | The FDA-Approved Breast Cancer HER2 Evaluation Kit (HercepTest; Dako) May Miss Some HER2-Positive Breast Cancers., HER2 fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests were performed on 52 cases using a US Food and Drug Administration (FDA)-approved kit (HercepTest, FDA kit) and a laborat... | yes |
converted_2848 | Is inositol effective for trichotillomania? | Patients assigned to inositol failed to show significantly greater reductions on primary or secondary outcomes measures compared with placebo (all P>0.05)., This is the first study assessing the efficacy of inositol in the treatment of trichotillomania, but found no differences in symptom reductions between inositol an... | no |
converted_2049 | Are the genes for marneral biosynthesis scattered in the genome of A. thaliana? | Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thaliana, compare the features of these two clusters, and investigate the evolutionary events that have led to cluster formation, Here we characterize a second operon-like triterpene cluster (the marneral cluster) from A. thalia... | no |
converted_1878 | Is there alternative polyadenylation during zebrafish development? | Extensive alternative polyadenylation during zebrafish development., At 2 h post-fertilization, thousands of unique poly(A) sites appear at locations lacking a typical polyadenylation signal, which suggests a wave of widespread cytoplasmic polyadenylation of mRNA degradation intermediates. Our insights into the identit... | yes |
converted_1082 | Are there any Decision support systems for chronic pain management ? | a project to operationalize the 2003 VA/DOD Clinical Practice Guideline for Opioid Therapy for Chronic Non-Cancer Pain into a computerized decision support system (DSS), We based the DSS on the existing ATHENA-DSS, Use of this iterative process led to development of a multifunctional DSS, interactive decision dashboard... | yes |
converted_4631 | Is taxilin a cancer marker? | Αlpha-Taxilin (α-Taxilin) has been found as one of the novel, significantly up regulated protein in RA, Expression of α-taxilin has been implicated in the development of human glioblastoma, hepatocellular carcinoma and renal cell carcinoma. , α-Taxilin, a binding partner of the syntaxin family, is a candidate tumor mar... | yes |
converted_4538 | Is lumbar puncture the first test that should be performed on a patient with increased intracranial pressure? | As an emergency diagnostic procedure, spinal puncture is indicated when CNS infection is suspected or to establish the diagnosis of subarachnoid hemorrhage when results of cranial computed tomography are normal. The major contraindication is elevated intracranial pressure with evidence of a mass lesion., Brain shift is... | no |
converted_3031 | Is cabozantinib effective for Hepatocellular Carcinoma? | However, clinical trials of nonselective kinase inhibitors with c-Met activity (tivantinib, cabozantinib, foretinib, and golvatinib) in patients with HCC have failed so far to demonstrate significant efficacy. , Rationale for use, clinical trial data, and current recommendations for cabozantinib in renal cell cancer, t... | yes |
converted_2436 | Is CREB a key memory protein? | Human cyclic AMP response element binding protein (CREB) transcription factor which plays a crucial role in memory, The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. , A mouse genetic study showed that cAMP-responsive element-binding prot... | yes |
converted_2050 | Is Dupilumab used for treatment of atopic dermatitis? | Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases., Background Dupilumab, a human monoclonal antibody against interleukin-4 receptor alpha, inhibits signaling of interleukin-4 and interleukin-13, type 2 cytokines that may be importan... | yes |
converted_3681 | Is Aptiganel effective for treatment of stroke? | Trends for increased mortality with three NMDA antagonists were seen - selfotel (OR 1.19 [0.81-1.74]), aptiganel (OR 1.32 [0.91-1.93]) and gavestinel (OR 1.12 [0.95-1.32]) - but this did not achieve significance for the NMDA antagonists considered as a class (1.09 [0.96-1.23]). Aptiganel was also associated with a tren... | no |
converted_3785 | Is yeast fbp1 affected by glucose starvation stress? | Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression, chromatin is reconstituted in the fission yeast Schizosaccharomyces pombefbp1 gene, which is robustly induced upon glucose starvation but tightly repressed under glucose-rich conditions., ... | yes |
converted_4691 | Is HYDIN (Hydrocephalus-inducing protein homolog) an axonemal protein? | Hydin was recently identified as an axonemal protein; however, its function is as yet unknown., precise axonemal location of hydin, a protein that, when mutated, causes hydrocephalus, and defined a unique role for hydin in ciliary motility. | yes |
converted_3184 | Are Crocus sativus compounds being considered against Alzheimer's disease? | Previous evidence suggested that Crocus sativus is linked to improving cognitive function in Alzheimer's disease (AD) patients. The aim of this study was to in vitro and in vivo investigate the mechanism(s) by which Crocus sativus exerts its positive effect against AD. , Collectively, findings from this study support t... | yes |
converted_745 | Is rivaroxaban metabolized in kidneys? | The novel oral anticoagulants (i.e., dabigatran, apixaban, rivaroxaban) all undergo renal metabolism to varying degrees, and hence dosing, efficacy, and safety require special consideration in CKD patients., The new oral anticoagulants have relatively little data in patients with severe renal impairment, and all have a... | yes |
converted_1167 | Is COL5A2 gene associated to ischemic heart disease? | Analysis of a gene co-expression network establishes robust association between Col5a2 and ischemic heart disease, Col5a2, a gene previously not specifically linked to MI response but responsible for the classic type of Ehlers-Danlos syndrome, was found to have many and strong co-expression associations within this com... | yes |
converted_4449 | Is Belimumab used for lupus nephritis? | In particular, depletion (Obinutuzumab, anti-CD20 monoclonal antibody) or neutralization (Belimumab, anti-"B-cell activating factor" monoclonal antibody) of B lymphocytes, and the use of a calcineurin inhibitor with a low profile of renal and systemic toxicity (Voclosporin) demonstrated an improvement in renal response... | yes |
converted_4681 | Is paxillin affected by RANKL? | Western blotting assays presented upregulated expressions of TNF receptor-activating factor 6 (TRAF6) and integrin β3 induced by gingipains and RANKL compared to RANKL alone. Enhanced integrin-related signaling was also demonstrated by elevated phosphorylations of FAK and paxillin compared to control. Moreover, the pit... | yes |
converted_124 | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | DITPA normalized the elevated serum T(3) and TSH when the dose reached 1 mg/kg · d and T(4) and rT(3) increased to the lower normal range., The identification of 3,5-diiodothyropropionic acid (DITPA) that binds to both α- and β-type TRs with relatively low affinity was unique in that this analog improves left ventricul... | yes |
converted_1992 | Is there a role of proton beam therapy in medulloblastoma treatment? | All papers directly compared outcomes from protons with photons, five papers included medulloblastoma, four papers each included craniopharyngioma and low grade gliomas and three papers included ependymoma., There are many indications of protontherapy for paediatric brain tumours in curative intent, either for localize... | yes |
converted_2851 | Is TIAM1 favoring tumor progression in colorectal cancer (CRC)? | Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling. We demonstrate that TIAM1 shuttles between the cytoplasm and nucleus antagonizing TAZ/YAP by distinct mechanisms in the two compartments. In the cytoplasm, TIAM1 localizes to the destruction c... | no |
converted_767 | Is tubulin acetylation involved in cell motility? | In this study, we found that paclitaxel induced tubulin acetylation in endothelial and tumor cells, at concentrations that affected cell motility but not proliferation (10(-8) to 10(-9) M, for 4 hours). Induction of tubulin acetylation correlated with inhibition of motility but not proliferation based on a comparison o... | yes |
converted_4367 | Can bergapten cross the blood-brain barrier? | Moreover, pharmacokinetic studies showed that bergapten has higher absolute bioavailability and can cross the blood-brain barrier and has a great potential for treating brain disease, but the mechanism needs further clarification to make greater use of its ability to treat brain diseases. | yes |
converted_1981 | Does the hERG gene code for a protein which is part of a sodium channel? | The human ether-à-go-go-related gene (hERG 1a) potassium channel is critical for cardiac repolarization, Human ether-a-go-go-related gene (hERG) channels conduct delayed rectifier K(+) current. , The KvLQT1 and minK genes code the slowly activating, delayed rectifier (Iks) potassium channel, the HERG gene code the rap... | no |
converted_1298 | Are there Conserved Noncoding Elements (CNEs) in invertebrate genomes? | Here, we use genome-wide comparisons between C. intestinalis and C. savignyi to identify putative urochordate cis-regulatory sequences. Ciona conserved non-coding elements (ciCNEs) are associated with largely the same key regulatory genes as vertebrate CNEs, We have identified Conserved Non-coding Elements (CNEs) in th... | yes |
converted_2009 | Can Pentraxin 3 predict outcomes of sepsis? | As compared with low serum PTX3and sTWEAK cases, cirrhotic patients with high serum PTX3/sTWEAK levels a have higher probability of new severe infections, severe sepsis, septic shock, type 1 hepatorenal syndrome, in-hospital, and 3-month follow-up mortalities. , Neonates with high nPTX3 concentrations also have lowered... | yes |
converted_3483 | Is Ubrogepant effective for migraine? | CGRP receptor antagonists such as ubrogepant are effective for acute relief of migraine headache, whereas monoclonal antibodies against CGRP (eptinezumab, fremanezumab and galcanezumab) or the CGRP receptor (erenumab) effectively prevent migraine attacks. , Despite the clear safety concerns, clinical trial data suggest... | yes |
converted_1987 | Is H4K20 methylation associated with DNA replication? | It seems likely that continued study of the methylation of H4K20 will yield extremely valuable insights concerning the regulation of histone modifications before and during cell division and the impact of these modifications on subsequent gene expression., Aberrant rereplication correlates with decreased levels of H4K2... | yes |
converted_1450 | Does the 3D structure of the genome remain stable during cell differentiation? | We identify large, megabase-sized local chromatin interaction domains, which we term 'topological domains', as a pervasive structural feature of the genome organization., The domains are stable across different cell types and highly conserved across species, indicating that topological domains are an inherent property ... | no |
converted_758 | Is PLK2 involved in alpha-synuclein phosphorylation in the nervous system? | Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system, Here we submit evidence that polo-like kinase 2 (PLK2, also known as serum-inducible kinase or SNK) is a principle contributor to alpha-synuclein phosphorylation at Ser-129 in neurons, PLK2 directly phosphorylates alpha-sy... | yes |
converted_1548 | Is the gene SLC6A2 associated with orthostatic intolerance? | Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. , Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intol... | yes |
converted_4316 | Is fusobacterium associated with Lemierre's syndrome? | Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study., Lemierre's syndrome is defined as an oropharyngeal infection due to Fusobacterium necrophorum,, Lemierre's syndrome is a rare but life-threatening condition characterized by an oropharyng... | yes |
converted_2421 | Is patisiran currently (November 2017) in clinical phase II trials? | This review addresses nine small-interfering RNAs (siRNAs) and one unique microRNA (miRNA) inhibitor, which entered the phase 2-3 clinical trials. The siRNAs in focus are PF-04523655, TKM-080301, Atu027, SYL040012, SYL1001, siG12D-LODER (phase 2), QPI-1002, QPI-1007, and patisiran (phase 3). , patisiran (phase 3), Ph... | no |
converted_2840 | Is Tisagenlecleucel effective for B-Cell Lymphoma? | The phase II JULIET trial suggests that the CD19-targeting CAR T-cell therapy tisagenlecleucel produces durable responses in patients with relapsed and refractory diffuse large B-cell lymphoma., Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia., BACKGROUND: In a single-center phase 1-2a ... | yes |
converted_187 | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | We show that treatment with b-AP15 inhibited tumor progression in four different in vivo solid tumor models and inhibited organ infiltration in an acute myeloid leukemia model. Our results show that the deubiquitinating activity of the 19S regulatory particle is a new anticancer drug target, We further found that ATO t... | yes |
converted_4475 | Is Acute Necrotizing Encephalopathy (ANE) which typically affects young, healthy children usually triggered by exposure to air pollution? | Acute necrotizing encephalopathy (ANE) is a recently identified, uncommon encephalopathy affecting children. ANE is characterized by a preceding viral illness followed by seizures and rapid progressive neurologic deterioration. , Acute necrotizing encephalopathy (ANE) is a specific type of encephalopathy usually follow... | no |
converted_2577 | Is Citrobacter rodentium pathogenic? | One day after colonization, mice were infected with the colonic pathogen, Citrobacter rodentium., The human pathogen enteropathogenic Escherichia coli (EPEC), as well as the mouse pathogen Citrobacter rodentium, colonize the gut mucosa via attaching and effacing lesion formation and cause diarrheal diseases., EPEC-like... | yes |
converted_3643 | Is Selumetinib effective for low-grade glioma? | Conclusion: Selumetinib has promising antitumor activity in children with LGG., INTERPRETATION
Selumetinib is active in recurrent, refractory, or progressive pilocytic astrocytoma harbouring common BRAF aberrations and NF1-associated paediatric low-grade glioma., These results show that selumetinib could be an alterna... | yes |
converted_2117 | Is Lennox-Gastaut Syndrome usually diagnosed in older adults? | We studied 15 LGS patients (mean age ± 1 standard deviation [SD] = 28.7 ± 10.6 years) and 17 healthy controls (mean age ± 1 SD = 27.6 ± 6.6 years), children with Lennox-Gastaut syndrome, Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by mixed seizures, cognitive decline, and genera... | no |
converted_2955 | Are Copy Number Variants (CNVs) depleted in regions of low mappability? | Human copy number variants are enriched in regions of low mappability., Applying PopSV to 640 human genomes, we find that low-mappability regions are approximately 5 times more likely to harbor germline CNVs, in stark contrast to the nearly uniform distribution observed for somatic CNVs in 95 cancer genomes. In additio... | no |
converted_3704 | Does radiotherapy for prostate cancer increase bladder cancer risk? | External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis., On multivariable competing risk regression analyses, treatment with EBRT was independently associated with the risk of developing a second prima... | yes |
converted_1493 | Was modafinil tested for schizophrenia treatment? | Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study., CONCLUSION: The data suggest that modafinil was a safe adjunctive treatment which improved p... | yes |
converted_4131 | Can Panitumumab cause trichomegaly? | Xerosis was present in two cases, and paronychia, pyogenic granuloma, trichomegaly, and madarosis were observed in one patient each. , Eyelash trichomegaly is an uncommon drug-associated sequelae experienced during treatment with epidermal growth factor receptor (EGFR) inhibitors. Elongation of the eyelashes induced by... | yes |
converted_1092 | Does amiodarone affect thyroid hormone receptors in the myocardium? | AM and Dron affected TR expression in the RA similarly by decreasing TRalpha 1 and beta 1 expression by about 50%, In the LVW, AM and Dron decreased TRbeta 1 and, interestingly, AM increased TRalpha 1., n the apex, AM also increased TRalpha 2., Both in treated and untreated mice, TRalpha2 mRNA had the highest density i... | yes |
converted_4697 | Is disruption of immune regulation mechanisms associated with adverse pregnancy outcomes, including preeclampsia (PE)? | Maternal systemic and placental inflammatory responses participate in the pathogenesis of hypertensive disorders of pregnancy including preeclampsia, a pregnancy-specific syndrome, although the role of inflammation remains unclear. , Our results indicate these proteins are new factors that play important roles in the ... | yes |
converted_3366 | Should Pentoxifylline be used for treatment of amyotrophic lateral sclerosis? | .RESULTS: At the end of the study, after 547 days of follow-up, 103 patients (51.7%) in the pentoxifylline group and 120 (59.7%) in the placebo group were alive (unadjusted risk 1.28, p = 0.107; adjusted risk 1.43, p = 0.02). In contrast, analysis of secondary outcome functional variables did not show the same negative... | no |
converted_3456 | Is Apremilast effective for Behçet’s Syndrome? | AREAS COVERED: This review provides a digest of all current experience and evidence about pharmacological agents recently described as having a role in the treatment of BS, including interleukin (IL)-1 inhibitors, tocilizumab, rituximab, alemtuzumab, ustekinumab, interferon-alpha-2a, and apremilast., CONCLUSIONS
Aprem... | yes |
converted_4273 | Is tofacitinib a JAK inhibitor? | The Janus Kinase inhibitor tofacitinib impacts human dendritic cell differentiation and favours M1 macrophage development., Tofacitinib, a small JAK inhibitor, is approved for the treatment of RA and has demonstrated good efficacy in psoriasis phase III clinical trials. | yes |
converted_2592 | Are there sex differences in the transcriptome of the mouse hippocampus? | To better understand the possible molecular basis for the sex-biased nature of neurological disorders, we used a developmental series of female and male mice at 1, 2, and 4 months of age to assess both mRNA and protein in the hippocampus with RNA-sequencing and mass-spectrometry, respectively., The bulk of these differ... | yes |
converted_1662 | Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)? | Notch receptors participate in a highly conserved signalling pathway that regulates normal development and tissue homeostasis in a context- and dose-dependent manner. Deregulated Notch signalling has been implicated in many diseases, but the clearest example of a pathogenic role is found in T-cell lymphoblastic leukaem... | yes |
converted_459 | Have mutations in the GARS gene been identified to cause Charcot-Marie-Tooth Disease Type 2D (CMT2D)? | Charcot-Marie-Tooth disease type 2D is a hereditary axonal and glycyl-tRNA synthetase (GARS)-associated neuropathy that is caused by a mutation in GARS. , Mutations in the GARS gene cause Charcot-Marie-Tooth 2D and distal spinal muscular atrophy type V - allelic disorders characterized by predominantly distal upper ext... | yes |
converted_3173 | Can prevnar 13 be used in children? | PCV13 is approved for routine vaccination of all infants as a 4-dose series at age 2, 4, 6, and 12-15 months for children who previously received 1 or more doses of the 7-valent pneumococcal conjugate vaccine (PCV7), and for children with underlying medical conditions that increase their risk for pneumococcal disease o... | yes |
converted_1475 | Is aganglionic megacolon a feature of Down syndrome? | Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS, Of the 17 patients with HD who w... | yes |
converted_1187 | Is there any link between conserved noncoding elements and alternative splicing in vertebrates? | Some of the most highly conserved sequences occur in genes encoding RNA binding proteins, particularly the RNA splicing-associated SR genes. Differences in sequence conservation between plants and animals are likely to reflect differences in the biology of the organisms, with plants being much more able to tolerate gen... | yes |
converted_182 | Does thyroid hormone regulate calcium transient in the myocardium? | 3-iodothyronamine (T(1)AM) is a novel endogenous relative of thyroid hormone, able to interact with trace amine-associated receptors, a class of plasma membrane G protein-coupled receptors, and to produce a negative inotropic and chronotropic effect, In adult rat cardiomyocytes acute exposure to 20 microM T(1)AM decrea... | yes |
converted_1396 | Is Crohn's disease (CD) linked to the consumption of refrigerated food? | Environmental risk factors playing a causative role in Crohn's Disease (CD) remain largely unknown. Recently, it has been suggested that refrigerated food could be involved in disease development., This study supports the opinion that CD is associated with exposure to domestic refrigeration, among other household facto... | yes |
converted_3183 | Are protamines ubiquitously expressed? | Protamines are nuclear proteins which are specifically expressed in haploid male germ cells. | no |
converted_827 | Are histone deacetylase (HDAC) inhibitors good candidates to control metastasis of solid tumors? | JNJ-26481585 also fully inhibited the growth of C170HM2 colorectal liver metastases, whereas again 5-fluorouracil/Leucovorin showed modest activity., Although not meeting the RECIST response criteria for adequate single-agent activity, the observed tolerable toxicities and the potential for clinical benefit in terms of... | yes |
converted_1691 | Is STAT3 transcription factor regulated by mTORC1? | Mechanistically, mTORC1 mediated IL-6-induced Stat3 activation in intestinal epithelial cells to stimulate the expression of downstream targets essential for cell proliferation and tissue regeneration. Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-... | yes |
converted_3539 | Are gut microbiota profiles altered by irradiation? | Specific Members of the Gut Microbiota are Reliable Biomarkers of Irradiation Intensity and Lethality in Large Animal Models of Human Health., Irradiation profoundly impacted gut microbiota profiles in both animals., Our findings suggest that gut symbiont-based probiotics can be used as agents for reversing radiation-i... | yes |
converted_4481 | Can Isradipine slow progression of Early Parkinson Disease? | Adjusted least-squares mean changes in total UPDRS score in the antiparkinson medication ON state over 36 months for isradipine and placebo recipients were 2.99 (95% CI, 0.95 to 5.03) points versus 3.26 (CI, 1.25 to 5.26) points, respectively, with a treatment effect of -0.27 (CI, -3.02 to 2.48) point (P = 0.85)., Conc... | no |
converted_2096 | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous cryptococcosis (PCC) without systemic infection is rare. , Cryptococcus is a ubiquitous fungus and is k... | no |
converted_3357 | Is SARS virus interacting with ACE2 encoded protein? | The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to postfusion conformation transition, The viral spike glycoprotein (S)... | yes |
converted_188 | Is there any link between CTF4 and CTF18 during sister chromatid cohesion? | Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring, These data defined two cohesion pathways, one containing CSM3, TOF1, CTF4, and CHL1, and the second containing MRC1, CTF18, CTF8, and DCC1, Here we show that three proteins requi... | yes |
converted_309 | Is TREM2 associated with Alzheimer's disease in humans? | Genetic deficits and loss of function for the triggering receptor expressed in myeloid cells 2 (TREM2; encoded at chr6p21.1), a transmembrane spanning stimulatory receptor of the immunoglobulin/lectin-like gene superfamily, have been associated with deficiencies in phagocytosis and the innate immune system in Alzheimer... | yes |
converted_3344 | Is marimastat effective for small-cell lung cancer? | The phase III trial in small cell lung cancer was discontinued when the results of study 140 were released in February 2001 showing that marimastat was not significantly more effective than placebo in prolonging the survival of small cell lung cancer patients., CONCLUSION: Treatment with marimastat after induction ther... | no |
converted_1581 | Can the iPS cell technology be used in Fanconi anemia therapy? | We explain a protocol for the reproducible generation of genetically corrected iPSCs starting from the skin biopsies of Fanconi anemia patients using retroviral transduction with OCT4, SOX2 and KLF4, Before reprogramming, the fibroblasts and/or keratinocytes of the patients are genetically corrected with lentiviruses e... | yes |
converted_2149 | Is apremilast effective for psoriasis? | CONCLUSION: Apremilast reduces the severity of nail/scalp psoriasis., CONCLUSIONS: Apremilast demonstrated clinically meaningful improvements in psoriatic arthritis and psoriasis at week 16; sustained improvements were seen with continued treatment through 52 weeks., Apremilast: A Novel Drug for Treatment of Psoriasis ... | yes |
converted_1640 | Is Turcot syndrome associated with glioblastoma? | Turcot syndrome is an autosomal recessive disorder clinically characterized by the occurrence of primary tumors of the central nervous system and adenomatous colonic polyps during the first or second decades of life, with a spectrum of clinical features such as "café-au-lait" spots, axillary freckling, and hyperpigment... | yes |
converted_1345 | Are DNA methylation maps applicable to the diagnosis of non-small-cell lung carcinomas? | Here we present a genome-wide DNA methylation analysis of NSCLC samples and paired lung tissues, where we combine MethylCap and next generation sequencing (MethylCap-seq) to provide comprehensive DNA methylation maps of the tumor and paired lung samples., Analysis of the MethylCap-seq data revealed a strong positive co... | yes |
converted_3248 | Is endotrophin derived from collagen? | endotrophin production from type IV collagen, High levels of COL6A3 and its cleaved product, endotrophin (ETP), Endotrophin is released from COL VI | yes |
converted_3471 | Are the members of the KRAB-ZNF gene family promoting gene repression? | The proteins encoded by these genes, whose expression is often tissue-specific, act as epigenetic suppressors contributing to the addition of repressive chromatin marks and DNA methylation., Here, using a reporter system, we show that TRIM28/KRAB-ZNFs alter DNA methylation patterns in addition to H3K9me3 to cause stab... | yes |
converted_3590 | Does association with the nuclear pore promote gene silencing? | Here, we show that the nucleoporin Nup358 plays an important role in this process. Nup358 localizes to the nuclear pore complex and to the cytoplasmic annulate lamellae (AL), and these structures dynamically associate with two mRNP granules: processing bodies (P bodies) and stress granules (SGs). , MicroRNA (miRNA)-gui... | yes |
converted_2246 | Is NEMO a zinc finger protein? | To better understand the thermodynamics and dynamics of the zinc finger of NEMO (NF-κB essential modulator), an alteration in the zinc finger domain of NEMO (K392R) , CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis., our simulations of the zinc finger NEMO, An important re... | yes |
converted_3608 | Is amantadine ER the first approved treatment for akinesia? | Extended-release amantadine (amantadine ER) is the first approved medication for the treatment of dyskinesia. | no |
converted_697 | Are there randomised controlled trials on sevoflurane? | After Ethics Review Board approval, 44 ASA I-III patients undergoing elective gynaecological surgery were randomised after surgery to either hypercapnic hyperpnoea or control groups., Hypercapnic hyperpnoea in spontaneously breathing patients halves the time of recovery from sevoflurane-induced anaesthesia in the opera... | yes |
converted_3390 | Are multipotent adult progenitor cells effective for treatment of stroke? | There was no difference between the multipotent adult progenitor cell group and placebo groups in global stroke recovery at day 90 (odds ratio 1·08 [95% CI 0·55-2·09], p=0·83).INTERPRETATION: Administration of multipotent adult progenitor cells was safe and well tolerated in patients with acute ischaemic stroke. Althou... | no |
converted_3687 | Is BCL11B involved in schizophrenia? | Interacting partners BCL11B and GATAD2A are also schizophrenia risk genes indicating that other genes interacting with or are regulated by SATB2 are making a contribution to schizophrenia and cognition . , Interacting partners BCL11B and GATAD2A are also schizophrenia risk genes indicating that other genes interacting ... | yes |
converted_3232 | Is subdural empyema a complication of sinusitis? | Acute and chronic sinusitis can give rise to a wide array of intracranial and orbital complications. These complications include brain abscess, subdural empyema,, A computed tomography scan showed bilateral paranasal sinus disease, and magnetic resonance imaging showed a right frontal abscess and subdural empyema., Fr... | yes |
converted_733 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
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