id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
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converted_4214 | Are there antimicrobial proteins in royal jelly? | Jellein, a peptide derived from royal jelly of honeybee has been shown to have promising effect against several bacterial and fungal species. , It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action agai... | yes |
converted_3978 | Can radiosurgery be used for the DNET tumors? | Salvage gamma knife radiosurgery in the management of dysembryoplastic neuroepithelial tumors: Long-term outcome in a single-institution case series., BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT/DNET) are rare epileptogenic tumors. Microsurgery remains the best treatment option, although case reports exist... | yes |
converted_525 | Are BBS mutations involved in syndromic Hirschsprung disease? | Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease, Here, we report 3 families with BBS and HSCR with concomitant mutations in BBS genes and regulatory RET elements, whose functionality is tested in physiologically relevant assays. Our data suggest that BBS m... | yes |
converted_353 | Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | In humans, the TCR coupling factor, CSB, plays a critical role in restoring transcription following both UV-induced and oxidative DNA damage. It also contributes indirectly to the global repair of some forms of oxidative DNA damage. The Escherichia coli homolog, Mfd, is similarly required for TCR of UV-induced lesions.... | yes |
converted_2658 | Does International Citicoline Trial on acUte Stroke trial supports efficacy of citicoline for stroke treatment? | The meta-analysis showed that no significant differences were found in the long-term mortality (OR=0.91, 95% CI 0.07 to 1.09, P=0.30), the rate of dependency (OR=1.02, 95% CI 0.87 to 1.24, P=0.85), and the effective rate (OR=0.98, 95% CI 0.84 to 1.14, P=0.82) between citicoline group and control group. , In conclusion... | no |
converted_386 | Is pesticide exposure associated with polyneuropathy? | As the syndrome occurred after the acute cholinergic syndrome but before organophosphate-induced delayed polyneuropathy, the syndrome was called 'intermediate syndrome'., The characteristic features of the IMS are weakness of the muscles of respiration (diaphragm, intercostal muscles and accessory muscles including nec... | yes |
converted_150 | Is PTEN involved in follicular thyroid carcinoma? | Two of the 259 patients (0.8%), with both follicular thyroid carcinoma and macrocephaly, were found to carry a germline mutation in the PTEN gene. The PTEN mutation frequency in unselected cases of follicular thyroid carcinoma was 4.8%, The frequency of germline pathogenic PTEN mutations in an unselected series of pati... | yes |
converted_3570 | Is palbociclib effective for glioblastoma? | Although further research is needed, cyclin-dependent kinase 4/6 inhibitors represent intriguing developments in the treatment of various malignancies, including those with such poor prognoses as glioblastoma multiforme, mantle cell lymphoma, and metastatic melanoma., CONCLUSION: In this trial, despite adequate tissue ... | no |
converted_154 | Does strenuous physical activity affect thyroid hormone metabolism? | The results of the present study in a unique experimental human model of maximal exposure to altitude and physical exercise demonstrate that extreme HA and strenuous physical exercise are coupled with specific endocrine adaptations. These include increased activity of the GH/IGF-I axis and a low T(3) syndrome, 3,5,3'-t... | yes |
converted_1800 | Does Vitamin D induce autophagy? | 1,25(OH)2D treatment was accompanied by autophagy activation , Autophagy signaling pathway was regulated by vitamin D3, vitamin D induces autophagy, Vitamin D shows promise for the prevention and amelioration of pathologic responses in IBD, an effect that is mediated, at least in part, by the induction and modulation ... | yes |
converted_2585 | Can CD55 deficiency cause thrombosis? | The loss of CD55 and CD59 renders PNH erythrocytes susceptible to intravascular haemolysis, which can lead to thrombosis and to much of the morbidity and mortality of PNH. , CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis., CONCLUSIONS: CD55 deficiency with hyperactivation of complement, angiop... | yes |
converted_1510 | Is gastro esophageal reflux related to burning mouth syndrome? | Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients., As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those... | no |
converted_766 | Does GC content vary markedly within a given isochore? | The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes., Isochores are large regions of relatively homogeneous nucleotide composition, Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) regions with a relatively h... | no |
converted_2106 | Does GATA-1 regulate ribosomal protein genes? | Mutations in exon 2 interfere with the synthesis of the full-length isoform of GATA-1 and lead to the production of a shortened isoform, GATA-1s. These mutations have been found in patients with Diamond-Blackfan anemia (DBA), a congenital erythroid aplasia typically caused by mutations in genes encoding ribosomal prote... | yes |
converted_724 | Are there any clinical trials of the effect of evening primrose oil on postmenopausal symptoms ? | To analyze whether the time (morning/evening) of administration of a compound containing 60 mg of dry soy seed extract (glycine max) with 40% of total isoflavones, primrose oil and α-tocopherol modifies the effect on the climacteric syndrome., The object of this study was to evaluate the effect of different doses of a ... | yes |
converted_4606 | Is REGN5458 a single-targeted antibody? | CD3-engaging bispecific antibodies (bsAbs) and chimeric antigen receptor (CAR) T cells are potent therapeutic approaches for redirecting patient T cells to recognize and kill tumors. Here we describe a fully human bsAb (REGN5458) that binds to B-cell maturation antigen (BCMA) and CD3, and compare its antitumor activiti... | no |
converted_764 | Is insulin-like growth factor-I (IGF-I) able to affect tendon protein synthesis in classic Ehlers-Danlos syndrome patients? | Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I, IGF-I injections significantly increased FSR values in cEDS patients but not in controls, In conclusion, baseline protein synthesis rates in connective tissue appeared normal in cEDS patients, and the pa... | yes |
converted_2307 | Do cephalopods use RNA editing less frequently than other species? | Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions, By adopting a method originally designed to detect linkage disequilibrium of DNA mutations, we exa... | no |
converted_3776 | Is MAGE-A3 immunotherapeutic effective for non-small-cell lung cancer? | INTERPRETATION: Adjuvant treatment with the MAGE-A3 immunotherapeutic did not increase disease-free survival compared with placebo in patients with MAGE-A3-positive surgically resected NSCLC. Based on our results, further development of the MAGE-A3 immunotherapeutic for use in NSCLC has been stopped., In the overall po... | no |
converted_2207 | Is Prochlorococcus the most abundant photosynthetic organism? | The marine cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism on Earth., The marine cyanobacterium Prochlorococcus is the numerically dominant photosynthetic organism in the oligotrophic oceans, and a model system in marine microbial ecology., The marine cyanobacterium Prochlorococ... | yes |
converted_4502 | Is autism thought to be related to the Arginine Vasopressin Peptide (AVP)? | However, we recently found that cerebrospinal fluid (CSF) concentration of the "social" neuropeptide arginine vasopressin (AVP) is significantly lower in pediatric ASD cases vs. controls., A large number of controlled trials demonstrated that exogenous oxytocin or arginine-vasopressin administration can mitigate social... | yes |
converted_4628 | Is tirabrutinib effective for lymphoma? | In March 2020, oral tirabrutinib was approved in Japan for the treatment of recurrent or refractory primary central nervous system lymphoma. Tirabrutinib is also under regulatory review in Japan for the treatment of Waldenström's macroglobulinemia and lymphoplasmacytic lymphoma. Clinical development is underway in the ... | yes |
converted_1225 | Is the regulation of Vsr endonuclease independent of the growth phase of bacteria? | Growth phase-dependent regulation of Vsr endonuclease, Vsr endonuclease levels are growth phase dependent., Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli., Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylas... | no |
converted_1487 | Does Serca2a bind PLN in the heart? | The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase., Moreover, PLN-R14Del did not co-immunoprecipitate with SERCA2a (as did WT-PLN),, n this review, we attempted to highlight the functional significance of PLN in vertebrate cardiac physiology. We will refer to ... | yes |
converted_3952 | Has ubrogepant entered clinical phase III trials? | Ubrogepant (MK-1602) is a novel, oral, calcitonin gene-related peptide receptor antagonist in clinical development with positive phase III outcomes for acute treatment of migraine., A population pharmacokinetic model describing the effect of formulations was included in the E-R simulation framework to assess potential ... | yes |
converted_828 | Is muscle lim protein (MLP) involved in cardiomyopathies? | Muscle LIM protein (MLP) has been proposed to be a central player in the pathogenesis of heart muscle disease. In line with this notion, the homozygous loss of MLP results in cardiac hypertrophy and dilated cardiomyopathy. Moreover, MLP is induced in several models of cardiac hypertrophy such as aortic banding and myoc... | yes |
converted_160 | Is there any software for automated analysis of FISH images? | he study demonstrated the feasibility of automated FISH signal analysis that applying a CAD scheme to the automated generated 2-D projection images., A color imaging technique, multiplex fluorescent in situ hybridization (M-FISH), has been developed to ease the analysis of the process. Using an M-FISH technique each ch... | yes |
converted_4409 | Does addition of valproic acid improve survival of patients with diffuse intrinsic pontine glioma? | Median event-free survival (EFS) and overall survival (OS) for DIPG were 7.8 (95% CI 5.6-8.2) and 10.3 (7.4-13.4) months, and estimated one-year EFS was 12% (2%-31%). Median EFS and OS for HGG were 9.1 (6.4-11) and 12.1 (10-22.1) months, and estimated one-year EFS was 24% (7%-45%). , CONCLUSION: Addition of VPA and bev... | no |
converted_275 | Is shotgun lipidomics the direct infusion of a lipid sample into a mass spectrometer? | In direct infusion/injection (or shotgun) lipidomics, An efficient shotgun lipidomics strategy was established and optimized for fast phospholipid profiling of viscera from three fish species: Lateolabrax japonicas, Ctenopharyngodon idellus, and Carassius auratus. This strategy relies on direct infusion of total lipid ... | yes |
converted_2598 | Does MC1R palmitoylation reduce pigmentation? | The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and enhances DNA repair after ultraviolet irradiation. , MC1R palmitoylati... | no |
converted_1835 | Do statins cause diabetes? | Statin use has been associated with increased risk of developing type 2 diabetes (T2DM), and with impaired glycemic control in T2DM patients, The relationship between T2DM and statins is further complicated since these drugs can cause new onset diabetes (NOD) although there is an overall benefit in terms of preventing ... | yes |
converted_900 | Are there plasma membrane receptors for thyroid hormones? | ntegrins are heterodimeric structural components of the plasma membrane whose ligands include a large number of extracellular matrix (ECM) proteins. , Recently, integrin αvβ3 has been shown to have a panel of previously unappreciated small molecule receptor sites for thyroid hormone and hormone analogues, for dihydrote... | yes |
converted_2229 | Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | Recently it was revealed that the secreted Proprotein Convertase Subtilisin Kexin 9 (PCSK9) binds with LDL-receptor (LDL-R) causing its degradation in the lysosome with the result of LDL-C accumulating in the blood., The major goal of this study is to identify peptide/s from the catalytic domain of hPCSK9 that can bloc... | no |
converted_3434 | Can CMB305 be used against sarcomas? | CMB305 induces NY-ESO-1 specific T cell responses in both SS and MRC patients and these patients had excellent overall survival (OS) outcomes in the initial phase I study., Data suggesting this vaccine may improve OS for SS and MRCL patients is exciting but early, and on-going work is testing the impact of CMB305 on pa... | yes |
converted_1989 | Does CRISPR inversion of CTCF sites alter genome topology? | CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function, To test the functional significance of this observation, we combined CRISPR/Cas9-based genomic-DNA-fragment editing with chromosome-conformation-capture experiments to show that the location and relative orientations of CBSs determine... | yes |
converted_1542 | Is thyroid hormone therapy indicated in patients with heart failure? | Patients with chronic heart failure and subclinical hypothyroidism significantly improved their physical performance when normal TSH levels were reached., Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarct scar size and prevents the progression towards heart failure. This b... | no |
converted_278 | Is the tricarboxylic acid (TCA) cycle affected in inflammation? | In this study, the levels of amino acids and trichloroacetic acid (TCA) cycle-related molecules in the colonic tissues and sera of patients with ulcerative colitis (UC) were profiled by gas chromatography/mass spectrometry (GC/MS), with the aim of evaluating whether the clinical state induced by UC leads to variations ... | yes |
converted_3544 | Is AND-1/Ctf4 essential for proliferation? | AND-1 fork protection function prevents fork resection and is essential for proliferation., AND-1/Ctf4 bridges the CMG helicase and DNA polymerase alpha, facilitating replication. Using an inducible degron system in avian cells, we find that AND-1 depletion is incompatible with proliferation, owing to cells accumulatin... | yes |
converted_930 | Is the length of the poly(A) tail involved in human disease? | In human mitochondria, polyadenylation of mRNA, undertaken by the nuclear-encoded mitochondrial poly(A) RNA polymerase, is essential for maintaining mitochondrial gene expression. Our molecular investigation of an autosomal-recessive spastic ataxia with optic atrophy, present among the Old Order Amish, identified a mut... | yes |
converted_2527 | Can doxycycline cause photosensitivity? | Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention., BACKGROUND: One of the most important dermatologic side effects of doxycycline is photosensitivity. , While there are many publications on the phototoxicity of tetracyclines in general, only a few exist ... | yes |
converted_2975 | Is dupilumab effective for treatment of asthma? | The appropriate use of these biologics, and of those in development (e.g., benralizumab and dupilumab), should be aided by further understanding of asthma phenotypes and endotypes, utilizing appropriate biomarkers., Simultaneous targeting of both IL-4 and IL-13 by blocking IL-4 receptor α using dupilumab has yielded mo... | yes |
converted_2279 | Is there increased recombination rate in human regulatory domains? | Evidence of reduced recombination rate in human regulatory domains., We study the relationship between recombination rate and gene regulatory domains, defined by a gene and its linked control elements. We define these links using expression quantitative trait loci (eQTLs), methylation quantitative trait loci (meQTLs), ... | no |
converted_2626 | Can nanoparticles be used for afterglow imaging? | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging, Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rar... | yes |
converted_4421 | Is the 22-item sino-nasal outcome test (SNOT-22) a widely used measure for Health-Related Quality-of-Life (HRQOL) associated with chronic rhinosinusitis (CRS)? | The Sino-Nasal-Outcome-Test-22 (SNOT-22) represents the reference questionnaire to assess symptoms, health-related quality-of-life (HRQOL) and treatment-response in patients with chronic rhinosinusitis (CRS). , Assessment of health-related quality-of-life in patients with chronic Rhinosinusitis - Validation of the Germ... | yes |
converted_3566 | Has LB-100 been tested in clinical trials? | To determine the MTD and to assess the safety, tolerability, and potential activity of LB-100, a first-in-class small-molecule inhibitor of protein phosphatase 2A (PP2A) in adult patients with progressive solid tumors., Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in... | yes |
converted_3440 | Does teplizumab hold promise for diabetes prevention? | Anti-CD3 teplizumab and anti-CD3 otelixizumab have been shown to provide C-peptide preservation. , Underway are secondary prevention studies with teplizumab and with abatacept., INTERPRETATION: Findings of exploratory analyses suggest that future studies of immunotherapeutic intervention with teplizumab might have incr... | yes |
converted_2424 | Are organisms in the genus Morexella associated with sepsis? | Out of 130 culture proven cases of neonatal sepsis, gram negative bacteria were found in 71 (54.6%) cases and gram positive bacteria in 59 (45.4%) cases. Staphylococcus aureus was the most common bacteria found in 35 (26.9%) cases followed by Escherichia coli in 30 (23.1%) cases. Acinetobacter species, Staphylococcus e... | yes |
converted_3686 | Does saracatinib promote oncogenesis? | Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer., We evaluated the antitumor effect of a c-Src/Abl kinase inhibitor, saracatinib (AZD0530), alone or combined with chemotherapeutic agents in gastric cancer cell lines and a ... | no |
converted_1655 | Are ultraconserved elements depleted among copy number variants (CNVs)? | We have demonstrated that nonexonic UCEs are depleted among segmental duplications (SDs) and copy number variants (CNVs) and proposed that their ultraconservation may reflect a mechanism of copy counting via comparison. Here, we report that nonexonic UCEs are also depleted among 10 of 11 recent genomewide data sets of ... | yes |
converted_2832 | Is durvalumab used for lung cancer treatment? | In the phase III PACIFIC trial consolidation with durvalumab, an anti-PDL-1 antibody, was associated with survival benefit in patients diagnosed with LA-NSCLC who responded to concurrent chemoradiotherapy., METHODS: An electronic literature search was performed of public databases (MEDLINE, Excerpta Medica dataBASE [E... | yes |
converted_3370 | Is Nivolumab (Opdivo) a PD-L1 inhibitor? | Fatal Myocarditis Following Treatment with the PD-1 Inhibitor Nivolumab, PD-1 inhibitor nivolumab (Opdivo), programmed cell death protein 1 (PD-1)-blocking antibodies nivolumab or pembrolizumab , An improvement in the understanding of the role of the immune system in tumor immunosurveillance has led to the development... | no |
converted_3749 | Is the TFR1 gene dispensable for erythropoiesis? | These studies describe how point mutations of the transferrin receptor can cause a microcytic anemia that does not respond to iron therapy and would not be detected by routine iron studies, such as serum ferritin., Ret-He was the only red cell marker affected prior to the onset of brain ID. The clinical practice of usi... | no |
converted_4161 | Does Curare function by stimulating the acetylcholine receptor? | Usual clinical concentrations of curare cause competitive inhibition of muscle nicotinic acetylcholine receptors while higher concentrations may induce open channel blockade., nicotinic acetylcholine receptor (nAChR)-blocking agents [e.g., curare or alpha-bungarotoxin (alpha-BTX), The short neurotoxins to which erabuto... | no |
converted_3157 | Is Apelin usually decreased in diabetes? | Apelin has been shown to act on glucose and lipid metabolism but also to modulate insulin secretion. Moreover, different studies in both animals and humans have shown that plasma apelin concentrations are usually increased during obesity and type 2 diabetes., Upregulated expression of resistin, vaspin, apelin and TNF-α... | no |
converted_3364 | Is PRDM9 essential for meiosis? | Our findings do not identify the nature of the underlying DNA sequences, but argue against the proposed role of Prdm9 as an essential transcription factor in mouse meiosis, PRDM9 gene polymorphism may not be associated with defective spermatogenesis in the Chinese Han population, PRDM9 is essential for the progression ... | yes |
converted_1980 | Could divalent metal transporter 1 deficiency lead to anemia? | The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Loss of DMT1 function results in microcytic anemia. , Dysfunction of human DMT1 is associated with several pathologies such as iron deficiency anemia hemochromatosis, Parkinson's disease and Alzheimer's ... | yes |
converted_3256 | Is ACE2 expressed on cell surfaces? | Recent studies reported that shedding of the enzymatically active ectodomain of ACE2 from the cell surface, ACE2 is a type 1 integral membrane protein and contains a catalytically active ectodomain that can be shed from the cell surface into the extracellular space, | yes |
converted_76 | Is CD56 useful in Ewing sarcoma prognosis? | Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry, There was a highly significant correlation between CD56 expression and progression-free survival (PFS; 69% in low/negative expression versus 30% in high expression groups, P = 0.024), In patients with lo... | yes |
converted_2210 | Is dupilumab an antibody targeting the IL-1 receptor? | Atopic dermatitis (AD) is characterized by type 2 helper T (Th2) cell-driven inflammation. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that blocks the signaling of IL-4 and IL-13, both key cytokines in Th2-mediated pathways., Dupilumab, a humanized monoclonal antibody to ... | no |
converted_727 | Is the optogenetics tool ChR2 light-sensitive? | Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology., Light-sensitive genes chiefly including the genetically targeted light-gated channels channelrhodopsin-2 (C... | yes |
converted_4608 | Is Benralizumab effective for Chronic Spontaneous Urticaria? | Finally, treatments aimed at reducing eosinophil accumulation and activation, such as the anti-IL-5 antibodies mepolizumab, reslizumab, and benralizumab, have been reported to reduce CSU symptoms. , The treatments that are under clinical trials for CSU are anti-IgE treatments such as ligelizumab, molecules targeting in... | yes |
converted_2150 | Is skin color affected by variations of the SLC24A5 gene? | the alleles of single-nucleotide polymorphisms rs1426654 and rs1834640 (SLC24A5) associated with light skin pigmentation in Eurasian populati, Associations between five single nucleotide polymorphisms (SNPs) known to play a role in pigmentation (rs1426654-SLC24A5, rs1042602-TYR, rs16891982-SLC45A2, rs6058017-ASIP, and ... | yes |
converted_1883 | Is there any tool that facilitates the functional analysis of cis-regulatory regions in zebrafish? | Zebrafish enhancer detection (ZED) vector: a new tool to facilitate transgenesis and the functional analysis of cis-regulatory regions in zebrafish., he cis-regulatory sequences control when, where, and how much genes are transcribed and can activate (enhancers) or repress (silencers) gene expression. Here, we describe... | yes |
converted_2227 | Is Downs syndrome associated with decreased risk of leukemia? | The association of Down's syndrome and leukemia has been documented for over 50 years. Multiple studies have established the incidence of leukemia in Down's syndrome patients to be 10- to 20-fold higher than that in the general population., We present a case of congenital acute myeloid leukemia manifesting from the ver... | no |
converted_1216 | Can desvenlafaxine be used at a dose of 50mg/day? | Long-term use of desvenlafaxine was safe and well tolerated, with a clinical benefit/risk profile similar to that in other populations., e objective of this study was to evaluate the long-term safety of desvenlafaxine for continuation treatment of major depressive disorder (MDD) in Japanese patients. This was a phase 3... | yes |
converted_2800 | Is P. gingivalis bacteria found in brain? | studies using animal model of periodontitis and human post-mortem brain tissues from subjects with AD strongly suggest that a gram-negative periodontal pathogen, Porphyromonas gingivalis (Pg) and/or its product gingipain is/are translocated to the brain., The polymicrobial dysbiotic subgingival biofilm microbes associa... | yes |
converted_2244 | Does RNA polymerase II have RNA cleavage activity? | In addition to RNA synthesis, multisubunit RNA polymerases (msRNAPs) support enzymatic reactions such as intrinsic transcript cleavage., msRNAP active sites from different species appear to exhibit differential intrinsic transcript cleavage efficiency and have likely evolved to allow fine-tuning of the transcription pr... | yes |
converted_2788 | Is pembrolizumab effective against Ewing's sarcoma? | None of the 13 patients with Ewing's sarcoma had an objective response. , Between March 13, 2015, and Feb 18, 2016, we enrolled 86 patients, 84 of whom received pembrolizumab (42 in each disease cohort) and 80 of whom were evaluable for response (40 in each disease cohort). | no |
converted_1754 | Could BRCA gene test used for breast and ovarian cancer risk? | Participation of Korean families at high risk for hereditary breast and ovarian cancer in BRCA1/2 genetic testing., The prevalence of BRCA1/2 mutations in Korean ovarian cancer patients irrespective of the family history was significantly higher than previously reported. Possible founder mutations in Korean ovarian can... | yes |
converted_1241 | Is poly (ADP- ribosylation) involved in transcriptional control? | Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivotal roles in the maintenance of transcriptional fidelity, oly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear protein that is involved in DNA r... | yes |
converted_4392 | Are TAMs good anticancer therapeutic targets? | Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients. | yes |
converted_2324 | Are mutations in the nf1 gene associated with memory? | We hypothesized that NF1 mutations disturb the expression of genes important for memory formation, Our previous work has shown that defective cAMP signaling leads to the learning phenotype in Drosophila Nf1 mutants. In the present report, our experiments showed that in addition to learning, long-term memory was also ab... | yes |
converted_172 | Is cytisine superior to nicotine replacement therapy for smoking cessation? | The effectiveness of cytisine for continuous abstinence was superior to that of nicotine-replacement therapy at 1 week, 2 months, and 6 months. In a prespecified subgroup analysis of the primary outcome, cytisine was superior to nicotine-replacement therapy among women and noninferior among men., CONCLUSIONS: When comb... | yes |
converted_420 | Are messenger RNA molecules epigenetically methylated? | The most abundant mRNA post-transcriptional modification is N(6)-methyladenosine (m(6)A), which has broad roles in RNA biology., N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate., Recently, methylation patterns have also been revealed ... | yes |
converted_2264 | Does deflazacort have more side effects than prednisone? | Though Deflazacort and prednisone improve clinical endpoints in Duchenne muscular dystrophy (DMD) patients, Deflazacort produces fewer side effects. | no |
converted_1392 | Do RNA:DNA hybrids preferentially form in high or low GC regions? | Intrinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [poly(U)] tract, and it has been proposed that steric clash of the stem-loop with the exit pore of the RNAP imposes a shearing force on the RNA in the downstream RNA:DNA hybrid... | yes |
converted_4351 | Are circRNAs susceptible to degradation by RNase R? | Currently, an increasing body of evidence has demonstrated that 1) majority of circRNAs are evolutionarily conserved across species, stable, and resistant to RNase R degradation, , Circular RNA (circRNA) has a closed-loop structure, and its 3' and 5' ends are directly covalently connected by reverse splicing, which is ... | no |
converted_3337 | Are Spinal Intradural Primary Malignant Peripheral Nerve Sheath Tumors(MPNST) rare in neurofibromatosis patients? | Spinal intradural primary malignant peripheral nerve sheath tumors (MPNST) are rare in patients without neurofibromatosis., Primary malignant peripheral nerve sheath tumors (MPNSTs) are extremely rare in patients without a history of neurofibromatosis; only 18 cases have been reported in the English-language literature... | no |
converted_1274 | Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity? | Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics are stem cell loss, causing progressive bone marrow failure and sterilit... | yes |
converted_3803 | Is Tcf3 associated with the Wnt pathway? | TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments, Furthermore, the role of miR-17 was because of its target gene TCF3 (transcription factor 3), a key transcription factor of canonical Wnt pathway., Co... | yes |
converted_1532 | Is selumetinib effective in thyroid cancer? | A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours., BACKGROUND: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selu... | yes |
converted_3540 | Is TIM-3 a target for cancer immunotherapy in NSCLC? | Our results imply that implementing combined treatment on CIK cells before transfusion via antibodies targeting PD-L1, LAG-3, TIM-3, and CEACAM-1 might improve the efficiency of CIK therapy for NSCLC patients., Furthermore, TIM-3 and CEACAM1 were strongly expressed simultaneously during long-term CIK culture and showe... | yes |
converted_2310 | Is there an association between carcinoid syndrome and mitral valve disease? | Other concomitant operations included mitral valve procedure (11%), aortic valve procedure (9%), patent foramen ovale or atrial septal defect closure (23%), cardiac metastasectomies or biopsy (4%), and simultaneous coronary artery bypass (11%). , High circulating serotonin (carcinoid syndrome) and serotoninergic drugs ... | yes |
converted_2889 | Does Panitumumab prolong survival of biliary tract cancer patients? | Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild-type KRAS advanced biliary tract cancer: A randomized phase 2 trial (Vecti-BIL study)., CONCLUSIONS: Panitumumab in combination with chemotherapy does not improve ORR, PFS and OS in patients with KRAS wild-type, advanced bilia... | no |
converted_3587 | Does Estrogen lead to forkhead FoxA1 activation? | We showed that CTCF acts upstream of the "pioneer" factor FOXA1 in determining the genomic response to estrogen. , Almost all ER-chromatin interactions and gene expression changes depended on the presence of FOXA1 and FOXA1 influenced genome-wide chromatin accessibility, FOXA1 is a key determinant of estrogen receptor ... | yes |
converted_3383 | AhR ligands are attractive drug targets for pharmaceutical development due to their induction of Cyp1a1, yes or no? | Based on our review of the data, there is little evidence to support the indiscriminate exclusion of AhR activators/Cyp1a1 inducers from early drug developmental pipelines. We also found no evidence that short-term treatment with RMAhRLs produce "dioxin-like toxicity", However, recent discoveries of new AhR ligands wi... | yes |
converted_3813 | Is aggrephagy a variant of autophagy? | The selective branch of autophagy that deals with identification, capture and degradation of protein aggregates is called aggrephagy., Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, , , it is largely unknown how misfolded polypeptides form aggresomes and... | yes |
converted_1699 | Is RIP1 (RIP-1) part of the necrosome? | formation of a different necrosome whose components, besides RIP1 and RIP3, are still unknown, necrosome complex consisting of RIP1, RIP3, FADD, caspase-8 and cFLIP(L)., assembly of a supramolecular complex containing the receptor-interacting protein kinases 1 and 3 (RIP1 and RIP3) that delivers a pronecrotic signal. S... | yes |
converted_874 | Is cystatin C or cystatin 3 used as a biomarker of kidney function? | to explore the effect of ageing on renal function with cystatin C as the marker of glomerular filtration rate (GFR) in the general population without vascular disease or diabetes., Cystatin C, a more specific kidney function biomarker, was also elevated at 24 h after CLP., This study evaluated FGF-23 as well as traditi... | yes |
converted_1281 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K , We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase,, TNNI3K, a cardiac-specific kinase, , The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy, Human cardiac t... | yes |
converted_3639 | Is poliosis circumscripta another term for a white or unpigmented patch of hair or skin? | "white forelock," poliosis circumscripta, defined as a localized patch of white hair in a group of hair follicle, Although traditionally known as "white forelock," poliosis circumscripta, defined as a localized patch of white hair in a group of hair follicles, can involve any hairy area on the body including the scalp,... | yes |
converted_2866 | Does simvastatin improve outcomes of aneurysmal subarachnoid hemorrhage? | Randomized controlled trials have shown that simvastatin and intravenous magnesium do not prevent DCI or improve functional outcomes after aneurysmal subarachnoid hemorrhage (aSAH)., Conclusions Simvastatin showed no benefits in decreasing the incidence of vasospasm, DCI, or all-cause mortality after aneurysmal SAH. We... | no |
converted_3114 | Is there any association between suicide and autism in adolescents, yes or no? | : In all subjects from our research on PubMed, 21.3% of subjects with autism spectrum disorder reported suicidal ideation, have attempted suicide or died by suicide (115 out of 539 subjects) and 7.7% of subjects supported for suicidal thoughts or attempted suicide exhibited an autism spectrum disorder (62 out of 806 su... | yes |
converted_1287 | Can the apoptosis regulator BAX trigger the release of cytochrome c? | 6-Shogaol reduced the mitochondrial membrane potential (MMP) and released cytochrome c from mitochondria to cytosol via Bax activation. , Moreover, overexpression of ERβ prevented Bax activation, cytochrome c release, caspase-3 activation, and PARP cleavage during apoptosis., In this study, we demonstrated that EV71 in... | yes |
converted_1896 | Has whole exome sequencing been performed in Alzheimer patients? | Pilot whole-exome sequencing of a German early-onset Alzheimer's disease cohort reveals a substantial frequency of PSEN2 variants., We performed whole-exome sequencing in early-onset Alzheimer disease (EOAD) and late-onset Alzheimer disease (LOAD) families followed by functional studies of select variants., Whole-exome... | yes |
converted_3557 | Are astronauts in higher risk for developing cancer? | Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. , No significant associations between space radiation dose and mortality were found using logistic regression with an internal reference group, adjusting for medical radiation., Despite ye... | no |
converted_2936 | Can midostaurin inhibit angiogenesis? | Midostaurin was a prototype kinase inhibitor, originally developed as a protein kinase C inhibitor and subsequently as an angiogenesis inhibitor, based on its inhibition of vascular endothelial growth factor receptor. | yes |
converted_2478 | Is there an association between Klinefelter syndrome and breast cancer? | Screening for breast cancer in male-to-female transsexuals should be undertaken for those with additional risk factors (e.g., family history, BRCA2 mutation, Klinefelter syndrome) and should be available to those who desire screening, preferably in a clinical trial., Klinefelter syndrome (OR = 24.7; 95% CI = 8.94 to 68... | yes |
converted_277 | Is apixaban effective for treatment of acute venous thromboembolism? | Apixaban is a direct inhibitor of factor Xa, and is a potential alternative for the treatment of acute venous thromboembolism. , These results suggest a lack of clear superiority of apixaban relative to enoxaparin. Apixaban is an oral alternative with similar efficacy and safety to existing anticoagulant therapies., A ... | yes |
converted_1623 | Is the Histidine-Rich Calcium Binding protein (HRC) related to arrhythmias and cardiac disease? | A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. , These findings suggest that aberrant SR Ca2+ release and increased susceptibility to delayed afterdepolarizations unde... | yes |
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