id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
values |
|---|---|---|---|
converted_3761 | Do nematodes contain architectural proteins like CTCF? | A mode of genetic regulation that involves insulators and insulator binding proteins to establish independent transcriptional units is currently not known in nematodes including Caenorhabditis elegans. , the insulator protein CTCF has been secondarily lost in derived nematodes like C. elegans., he most highly enriched ... | no |
converted_2881 | Is collagen the most abundant human protein? | As the most abundant protein in the body, collagen is essential to maintain the normal structure and strength of connective tissue, such as bones, skin, cartilage, and blood vessels., Collagen is the most abundant protein family in mammals., Collagen is a fibrillar protein that conforms the conjunctive and connective t... | yes |
converted_1589 | Has proteomics been used in the study of the dry eye syndrome? | Tear proteomic analysis of patients with type 2 diabetes and dry eye syndrome by two-dimensional nano-liquid chromatography coupled with tandem mass spectrometry., Dry eye syndrome in diabetic patients is associated with aberrant expression of tear proteins, and the findings could lead to identification of novel pathwa... | yes |
converted_4194 | Is adenosine signaling prognostic for cancer outcome? | Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response., There are several agents in early clinical trials targeting components of the adenosine pathway including A2AR and CD73. The identification of cancers with a significant adenosine drive is critical to unders... | yes |
converted_3863 | Is liraglutide effective for weight reduction? | Liraglutide has been approved at higher dose for obesity. , This meta-analysis finds a significant reduction in body weight with orlistat (N = 10,435; ∆ -3.07 Kg, 95% CI, -3.76 to -2.37), phentermine plus topiramate (N = 2985; ∆ -9.77 Kg; 95% CI, -11.73 to -7.81), lorcaserin (N = 16,856; ∆ -3.08 Kg; 95% CI, -3.49 to -2... | yes |
converted_792 | Is protein CXCR4 used as a prognostic marker of cancer? | Aberrant overexpression of CXCR4 is associated with worse overall survival, adenocarcinoma histology, distant metastasis, lymph node involvement in NSCLC., CXCR4 belongs to a family of G protein-coupled cell surface receptors and has been proved to a prognostic marker in a various tumors, including esophageal squamous ... | yes |
converted_2659 | Is human lysyl oxidase-like 2 a glycoprotein? | This method was successfully applied to a novel recombinant protein, human lysyl oxidase-like 2. Furthermore, the glycosylation PTMs were readily detected at two glycosylation sites in the protein. , application to the characterization of human lysyl oxidase-like 2 glycosylation, These results suggest that the N-glycan... | yes |
converted_4559 | Is there an association between pyostomatitis vegetans and Crohn's disease? | Among the main oral manifestations of IBD are cobblestoning of the oral mucosa, labial swellings with vertical fissures, pyostomatitis vegetans, angular cheilitis, perioral erythema, and glossitis. , Pyostomatitis Vegetans: A Clue for Diagnosis of Silent Crohn's Disease., We present a case of Pyostomatitis vegetans inv... | yes |
converted_1278 | Is there evidence for de novo genesis of enhancers in vertebrates? | De novo genesis of enhancers in vertebrates., Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhan... | yes |
converted_572 | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB, phosphorylation of PLN, at either Ser(16) by PKA , Activation of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB), which relieves the inhibitory effects of PLB... | yes |
converted_1604 | Are pseudogenes enriched with housekeeping protein families? | housekeeping families tend to be enriched with a large number of pseudogenes | yes |
converted_1817 | Is SUMOylation a post-translational modification in eukaryotes? | SUMOylation, the conjugation of target proteins with SUMO (small ubiquitin-related modifier), is a type of post-translational modification in eukaryotes and involves the sequential action of activation (E1), conjugation (E2) and ligation (E3) enzymes. , Plants have evolved to cope with changing environmental conditions... | yes |
converted_2911 | Are there ultraconserved regions in the budding yeast (Saccharomyces cerevisiae)? | The systematic analysis of ultraconserved genomic regions in the budding yeast., In the evolution of species, a kind of special sequences, termed ultraconserved sequences (UCSs), have been inherited without any change, which strongly suggests those sequences should be crucial for the species to survive or adapt to the ... | yes |
converted_1978 | Do histone variant mH2A (macro-H2A) levels decrease upon differentiation? | Through manipulation of macroH2A isoforms, we further demonstrate that macroH2A2 is the predominant barrier to reprogramming., In particular, we find macroH2A isoforms to be highly enriched at target genes of the K27me3 demethylase, Utx, which are reactivated early in iPS reprogramming, Therefore, we propose that macr... | no |
converted_705 | Is Bladder training an effective method to treat urge incontinence ? | Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of drug treatment and bladder training in reducing urge incontinence and incontinence-related quality of life., All patients, irrespective of the results of cystometry wer... | yes |
converted_3610 | Is g-H2AX a marker for double strand breaks? | The specific phosphorylation of histone H2AX on serine residue 139, described as γ-H2AX, is an excellent indicator or marker of DNA double-strand breaks (DSBs). , expression of the DNA double-strand break marker gamma-H2AX (γH2AX) , pH2AX, a marker of the DNA double-strand break (DSB) | yes |
converted_3475 | Is the protein ABCG2 (ATP-Binding Cassette, subfamily G, member 2, transporter) excreting uric acid? | TP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a well-studied urate transporter expressed on apical membranes in several tissues, including the intestine, liver, and kidney., the discovery that ABCG2 plays a central role on extra-renal uric acid excretion, | yes |
converted_2590 | Does temsirolimus improve survival of glioblastoma patients? | RESULTS: fourteen randomized clinical trials were identified (7 with bevacizumab, 2 cilengitide, 1 enzastaurin, 1 dasatinib, 1 vandetanib, 1 temsirolimus, 1 cediranib) including 4330 patients. Antiangiogenic drugs showed no improvement in overall survival with a pooled HR of 1.00, a trend for an inferior outcome, in te... | no |
converted_95 | Does the CTCF protein co-localize with cohesin? | To investigate cohesin-non-CTCF (CNC) binding events in vivo we mapped cohesin and CTCF, as well as a collection of tissue-specific and ubiquitous transcriptional regulators using ChIP-seq in primary mouse liver., In contrast to regions of the genome where cohesin and CTCF colocalize, CNC sites coincide with the bindin... | yes |
converted_3399 | Does CXorf21 escape X chromosome inactivation? | This revealed a 637-kb tandem duplication that in addition to DAX1 includes the four MAGEB genes, the hypothetical gene CXorf21, GK, and part of the MAP3K7IP3 gene, Among statin users, diabetes cases had marginal but insignificantly different expression of ZNF532 (up-regulated 15%, Q-value=0.0584), CXORF21 (up-regulate... | yes |
converted_1826 | Is the protein lefty an inhibitor of nodal? | The expression of lefty, an inhibitor of nodal is often reduced in tumor cells., Nodal, and an inhibitor, Lefty., as well as the expression of Lefty, an inhibitor of nodal signaling,, he Nodal inhibitor lefty, The morphogen Nodal was proposed to form a long-range signaling gradient via a reaction-diffusion system, on ... | yes |
converted_3368 | Is the CADM2 gene associated with differences in information processing speed? | GWAS for executive function and processing speed suggests involvement of the CADM2 gene., A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(... | yes |
converted_1297 | Is micro RNA 1 (miR-1) implicated in cardiac arrhythmias? | Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT)., miR-1 overexpression may contribute to the increased susceptibility of the heart to AVB, which provides us novel insights into the molecular mechanisms underly... | yes |
converted_1596 | Have thyronamines effects on fat tissue? | Intraperitoneal or central injection of 3-T(1)AM or T(0)AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. | yes |
converted_1551 | Can we use platelet biomarkers to study Alzheimer's disease? | Platelet biomarkers in Alzheimer's disease., platelets are the most important source of circulating forms of the amyloid precursor protein and other important proteins such as Tau and glycogen synthase kinase-3B., Alternative plasma and platelet measures are described,, The success of these studies led to the applicati... | yes |
converted_3054 | Is the yeast (Saccharomyces cerevisiae) genome organized into topologically associated domains (TADs)? | Recent advances in our understanding of the three-dimensional organization of the eukaryotic nucleus have rendered the spatial distribution of genes increasingly relevant. In a recent work (Tsochatzidou et al., Nucleic Acids Res 45:5818-5828, 2017), we proposed the existence of a functional compartmentalization of the ... | yes |
converted_4696 | Do Afamin bind Vitamin E? | The plasma glycoprotein afamin has been previously identified as an alternative carrier protein for vitamin E in extravascular fluids such as plasma and cerebrospinal, ovarian follicular, and seminal fluids., afamin, a vitamin E-binding protein in human plasma, the human vitamin E-binding protein afamin, Afamin is a pl... | yes |
converted_2496 | Does prolactinoma increase osteoporosis risk? | Prolactinoma: A Massive Effect on Bone Mineral Density in a Young Patient., Osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. This case shows a similar impact on bone health in a young male resulting in low bone mineral density for age based on Z-score. This case report highlights t... | yes |
converted_3168 | Tocilizumab is an anti-TNF antibody, yes or no? | was treated with tocilizumab, an anti-interleukin-6 receptor monoclonal antibody , Tocilizumab (TCZ) is a humanized monoclonal antibody against IL-6 receptor licensed in 2009 that has demonstrated clinical efficacy in various adult RA populations. RA management guidelines and recommendations consider TCZ as one of the ... | no |
converted_2245 | Is there a sequence bias in MNase digestion patterns? | In addition, unlike MNase, MPE-Fe(II) cleaves nuclear DNA with little sequence bias., These findings collectively indicate that MPE-seq provides a unique and straightforward means for the genome-wide analysis of chromatin structure with minimal DNA sequence bias., Micrococcal nuclease does not substantially bias nucleo... | yes |
converted_1846 | Can Diabetes be caused by a defect in a potassium chanel? | Mutations in KATP channel genes can result in hypo- or hypersecretion of insulin, as in neonatal diabetes mellitus and congenital hyperinsulinism, respectively., To date, all patients affected by neonatal diabetes due to a mutation in the pore-forming subunit of the channel (Kir6.2, KCNJ11) are heterozygous for the mut... | yes |
converted_317 | Have mutations in the Polycomb group been found in human diseases? | We identify a novel mutation in PHC1, a human orthologue of the Drosophila polyhomeotic member of polycomb group (PcG), which significantly decreases PHC1 protein expression, increases Geminin protein level and markedly abolishes the capacity to ubiquitinate histone H2A in patient cells., In clinical specimens of head ... | yes |
converted_3889 | Is Hunter's disease is associated with the X Chromosome? | Segregation analysis on five samples of families with Hunter's syndrome (158 cases overall) shows that the mutant allele segregates in agreement with Mendelian expectations for an X linked recessive, The utility of polymerase chain reaction (PCR) amplification of amelogenin gene as a reliable and rapid means of determi... | yes |
converted_1466 | Is the HRC Ser96Ala variant associated with sudden cardiac death in patients with dilated cardiomyopathy? | The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM., The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been ... | yes |
converted_1203 | Is muscle regeneration possible in mdx mice with the use of induced mesenchymal stem cells? | Purified iMSCs displayed fibroblast-like morphology, formed three-dimensional spheroid structures, and expressed characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105. Moreover, iMSCs were capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Transpl... | yes |
converted_1758 | Has Glucose-6-phosphate dehydrogenase (G6PD) deficiency an X-linked inheritance? | Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance. , This genetic defect shows sex linked inheritance and a marked heterogeneity., G6PD deficiency is the most common enzymopathy in the world. , Study of the deficiency pattern amongst fami... | yes |
converted_1057 | Are there clinical trials on stem cells in multiple sclerosis | Cells are generally given intravenously. Multiple sclerosis, rheumatoid arthritis and lupus have been successfully treated in human clinical trials, Human multipotent mesenchymal stem cell (MSC) therapies are currently being tested in clinical trials for Crohn's disease, multiple sclerosis, graft-versus-host disease, t... | yes |
converted_2630 | Is there any role of interleukin-11 in cardiovascular fibrosis? | IL11 is a crucial determinant of cardiovascular fibrosis., Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect. IL11 and its receptor (IL11RA) are expr... | yes |
converted_4633 | Is PCAT6 a microRNA? | In this work, we investigated the role and regulatory mechanism of lncRNA prostate cancer-associated transcript 6 (PCAT6) in breast cancer progression. | no |
converted_1619 | Does triiodothyronine play a regulatory role in insulin secretion from pancreas? | Our findings establish that p43 is an important regulator of glucose homeostasis and pancreatic β-cell function and provide evidence for the first time of a physiological role for a mitochondrial endocrine receptor., The p43(-/-) mice had a major defect in insulin secretion both in vivo and in isolated pancreatic islet... | yes |
converted_3959 | Are PDXK mutations linked to polyneuropathy? | PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation., To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy.METHODS: We performed genome-wide sequencing, homozygosity mapping, and segregation ana... | yes |
converted_1238 | Is the Snord116 cluster associated with the Prader-Willi syndrome? | All three deletions included SNORD116, but only two encompassed parts of SNURF-SNRPN, implicating SNORD116 as the major contributor to the Prader-Willi phenotype. Our case adds further information about genotype-phenotype correlation and supports the hypothesis that SNORD116 plays a major role in the pathogenesis of Pr... | yes |
converted_511 | Is Alpers disease inherited in an autosomal recessive mode? | Alpers-Huttenlocher syndrome (AHS) is a very rare autosomal recessive disorder, Alpers syndrome is an autosomal recessive mitochondrial DNA depletion disorder that affects children and young adults, Alpers' syndrome is a fatal neurogenetic disorder first described more than 70 years ago. It is an autosomal recessive, d... | yes |
converted_895 | Does the histidine-rich Ca-binding protein (HRC) interact with triadin? | The HRC effects on RyR may be regulated by the Ca(2+)-sensitivity of its interaction with triadin., In rabbit skeletal and cardiac muscles, HRC binds to sarcoplasmic reticulum (SR) membranes via triadin, a junctional SR protein. , HRC may play a key role in the regulation of SR Ca cycling through its direct interaction... | yes |
converted_5 | Does metformin interfere thyroxine absorption? | LT4 absorption is unchanged by concomitant metformin ingestion., It has been hypothesized that metformin may suppress serum thyrotropin (TSH) concentrations by enhancing LT4 absorption or by directly affecting the hypothalamic-pituitary axis. | no |
converted_967 | Are CTCF and BORIS involved in genome regulation and cancer? | CTCF is ubiquitously expressed and plays diverse roles in gene regulation, imprinting, insulation, intra/interchromosomal interactions, nuclear compartmentalisation, and alternative splicing. CTCF has a single paralogue, the testes-specific CTCF-like gene (CTCFL)/BORIS. CTCF and BORIS can be deregulated in cancer. The ... | yes |
converted_129 | Is amantadine effective for treatment of disorders conciousness? | We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from coma. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, leading sometimes to dramatic ... | yes |
converted_3900 | Are Toll-like receptors (TLRs) induced by microbes? | The C-type lectin receptor CLEC4E and Toll-like receptor TLR4 expressed by host cells are among the first line of defense in encountering pathogens., Gram-negative bacteria and endogenous molecules coordinate to trigger inflammatory cascades via Toll-like receptor 4 to induce excessive expression of cytokines such as t... | yes |
converted_4377 | Can bergapten cause phototoxicity? | Furthermore, the phototoxicity of bergapten combined with ultraviolet light has always been mentioned., The phototoxicity of bergapten as a side effect should be further avoided. | yes |
converted_3024 | Is deletion at 6q24.2-26 associated with longer survival of patients with high-grade serous ovarian carcinoma (HGSOCs)? | Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients., We found that loss at 6q24.2-26 was significantly associated with the cluster of longer survival independently from other confounding factors (HR = 0.06, 95%CI = 0.01-0.43, Padj = 0.005). The prognostic value of thi... | yes |
converted_1766 | Is ocrelizumab effective for treatment of multiple sclerosis? | Advances made in immunomodulation are driving the progress being made in the treatment of MS. Ocrelizumab is the first treatment with positive results in the primarily progressive forms and tocilizumab, a drug product for rheumatoid arthritis, stands out as a potential candidate for the treatment of neuromyelitis opti... | yes |
converted_4698 | Can autophagy related lncRNAs be used for colorectal cancer prognosis? | A Novel Prognostic Prediction Model for Colorectal Cancer Based on Nine Autophagy-Related Long Noncoding RNAs, A prognostic prediction model of CRC was built based on nine ARlncRNAs (NKILA, LINC00174, AC008760.1, LINC02041, PCAT6, AC156455.1, LINC01503, LINC00957, and CD27-AS1). The 5-year overall survival rate was sig... | yes |
converted_3273 | Has the drug Afrezza been approved by the FDA? | In contrary, MannKind Corporation started developing its ultra-rapid-acting insulin Afrezza in a bold bid, probably by managing the issues in which Exubera was not successful. Afrezza has been marketed since February, 2015 by Sanofi after getting FDA approval in June 2014. | yes |
converted_3760 | Are bacteria in the genus Clostridium facultative anaerobes? | strict anaerobe Clostridium acetobutylicum, Clostridia belong to those bacteria which are considered as obligate anaerobe, e.g. oxygen is harmful or lethal to these bacteria., We report here the closed genome of Clostridium pasteurianum ATCC 6013, a saccharolytic, nitrogen-fixing, and spore-forming Gram-positive obliga... | no |
converted_4266 | Is cytokeratin a tumor marker? | cytokeratin fragment antigen 21-1 (CYFRA21-1) in patients with laryngeal squamous cell carcinoma (LSCC) and its correlation with tumorigenesis and progression, cytokeratin fragment 19 (AUC=0.6882, p<0.0001) proved best in detecting relapse., The immunohistochemistry staining for cancer antigen 19-9, carcinoembryonic a... | yes |
converted_577 | Is paramyxovirus involved in human subacute thyroiditis? | Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus. Influenza immunization or infection may cause subacute thyroiditis., Coxsackie virus has been reported to be one of the viruses associated with the disease., The etiology o... | no |
converted_3094 | Can cardiospheres be produced from skin fibroblasts? | Therefore, there is an emerging interest in generating cardiosphere-like stem cells from somatic cells via somatic reprogramming. , Here we provide the detailed protocol for generating induced cardiospheres (iCS) for cardiac regeneration by somatic reprogramming of mouse fibroblasts using a panel of pluripotent transcr... | yes |
converted_700 | Can FOXOs modulate longevity? | Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan., In contrast to FoxO1, FoxO3a and FoxO6 were specifically diminished in the CNS of HFD animals possibly contributing to the reduced lifespan observed in these animals., Interestingly, many target proteins of AMPK are ... | yes |
converted_93 | Have Quantitative Trait Loci affecting splicing (splicing QTLs) been linked to disease? | The spontaneously hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. Previously we identified thousands of cis-regulated expression quantitative trait loci (eQTLs) across multiple tissues using a panel of rat recombinant inbred (RI) strains derived from Brown Norway and SHR pro... | yes |
converted_3231 | Is CD63 an exosomal marker? | f exosome marker proteins (e.g., CD63, Alix) , CD63 levels and acetylcholinesterase (AChE) activity were used as markers of exosome,, The results demonstrated these exosomes all expressed CD9, CD63, CD81, Alix | yes |
converted_3280 | Is Protoporphyrinogen oxidase localized to the mitochondrium? | We showed that 28 amino acids in the amino terminus of PPOX contain an independently functioning signal for mitochondrial targeting., Based on our results we propose a mechanism for protoporphyrinogen oxidase targeting to the mitochondrion., Mitochondrial targeting of human protoporphyrinogen oxidase., In the present s... | yes |
converted_2056 | Is PUVA therapy indicated for eczema treatment? | With bath PUVA treatment, the best results were found in patients with hyperkeratotic eczema (17/22; 77% good clinical response) followed by patients with palmoplantar psoriasis (26/41; 63%) and patients with dyshidrotic eczema (8/16; 50%). , Oral vs. bath PUVA using 8-methoxypsoralen for chronic palmoplantar eczema., ... | yes |
converted_882 | Is nivolumab used for treatment of Non–Small-Cell Lung Cancer? | BACKGROUND: Patients with advanced squamous-cell non-small-cell lung cancer (NSCLC) who have disease progression during or after first-line chemotherapy have limited treatment options. This randomized, open-label, international, phase 3 study evaluated the efficacy and safety of nivolumab, a fully human IgG4 programmed... | yes |
converted_1778 | Is NADPH oxidase 5 expressed in rodents? | Because the Nox5 gene is absent in rodents, we generated transgenic mice expressing human Nox5 in a podocyte-specific manner (Nox5(pod+)). , The NADPH oxidase 5 (NOX5) gene is present in humans but not rodents. , The data document that the NOX5 gene was expressed in cells of lagomorphs unlike rodents, making the rabbit... | no |
converted_1505 | Is it possible to visualize subtahalamic nucleus by using transcranial ultrasound? | After measuring thermal effects of TCS and imaging artefact sizes of DBS lead using a skull phantom, we prospectively enrolled 34 patients with DBS of globus pallidus internus, ventro-intermediate thalamic or subthalamic nucleus. TCS had no influence on lead temperature, electrical parameters of DBS device or clinical ... | yes |
converted_51 | Is peripheral neuroepithelioma related to Ewing sarcoma? | The term "small round-cell tumor" describes a group of highly aggressive malignant tumors composed of relatively small and monotonous undifferentiated cells with high nuclear to cytoplasmic ratios. This group includes Ewing's sarcoma (ES), peripheral neuroepithelioma (aka, primitive neuroectodermal tumor or extraskelet... | yes |
converted_282 | Is the Wnt protein modified by notum? | Notum deacylates Wnt proteins to suppress signalling activity., Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase., the Wnt inhibitor notum, ... | yes |
converted_2040 | Does Yersinia pestis causes a respiratory infection? | Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia, Yersinia pestis causes the fatal respiratory disease pneumonic plague., Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal disease., Pulmon... | yes |
converted_1965 | Is butterfly rash a symptom of Systemic lupus erythematosus? | Diagnosing SLE can be challenging because of the myriad of clinical features and substantial variability between patients. Cutaneous involvement is present in about 60% of cases and typically manifests as a malar or butterfly rash., The prevalence of systemic lupus erythematosus (SLE) is 28 per 100,000. , We report a 1... | yes |
converted_3635 | Can LB-100 downregulate miR-33? | PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation., LB100 profoundly upregulates miR-181b-1, which we show directly binds to the 3' untranslated region of Bcl-2 mRNA leading to its translational inhibition. MiR-181b-1 ectopic overexpres... | no |
converted_2101 | Is Obeticholic Acid used for treatment of Primary Biliary Cholangitis? | Obeticholic acid in primary biliary cholangitis., In a double-blind, randomized, placebo-controlled study including 217 patients with primary biliary cholangitis, the authors show that obeticholic acid (a potent farnesoid X agonist) administered with ursodeoxycholic acid or as monotherapy significantly decreases serum ... | yes |
converted_2799 | Can simvastatin alleviate depressive symptoms? | Simvastatin-treated patients experienced significantly more reductions in HDRS scores compared to the placebo group by the end of the trial (p=0.02). Early improvement and response rates were significantly greater in the simvastatin group than the placebo group (p=0.02 and p=0.01, respectively) but remission rate was n... | yes |
converted_3012 | Is pimavanserin effective for Parkinson's disease psychosis? | Two cases of Parkinson's disease with an unusual delusional misidentification, intermetamorphosis, are presented, along with their improvement with pimavanserin, a novel atypical antipsychotic medication., RATIONALE: Pimavanserin, a selective serotonin 2A receptor inverse agonist, is a promising candidate for treating ... | yes |
converted_634 | Could Arimidex (anastrozole) cause hot flashes? | More than a third of breast cancer patients undergoing aromatase inhibitor (AI) treatment report joint pain., In the first 6 weeks, emergence of joint pain was associated with increase in general pain, fatigue, disturbed sleep, hot flashes, vaginal dryness, and decreased sexual activity., Antiestrogen therapy can cause... | yes |
converted_3701 | Have toll-like receptor 2 activators been found in food? | Toll-like receptor 2 (TLR2) is a widely expressed pattern recognition receptor critical for innate immunity. TLR2 is also a key regulator of mucosal immunity implicated in the development of allergic disease. TLR2 activators are found in many common foods,, TLR2 activators are found in many common foods, but the role o... | yes |
converted_3027 | Can mogamulizumab be used for the treatment of cutaneous T-cell lymphoma? | In the large international phase III MAVORIC trial, patients with previously treated cutaneous T-cell lymphoma who received the anti-CCR4 monoclonal antibody mogamulizumab experienced significantly longer progression-free survival and higher response rates, as well as better quality of life, than those who received vor... | yes |
converted_1226 | Are there interactomes available for POU5F1 and SOX2? | The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells., We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent interacting regions mainly overlap with early DNA re... | yes |
converted_3960 | Is avelumab effective for urothelial carcinoma? | ince then, additional checkpoint inhibitors, including avelumab, durvalumab, and nivolumab, have gained approval. , Avelumab, an anti-programmed death-ligand 1 monoclonal antibody approved for the treatment of metastatic Merkel cell carcinoma and platinum-treated urothelial carcinoma, was initially approved with a 10 m... | yes |
converted_2171 | Is tirilazad effective for treatment of aneurysmal subarachnoid haemorrhage? | There was no significant difference between the two groups at the end of follow up for the primary outcome, death (odds ratio (OR) 0.89, 95% confidence interval (CI) 0.74 to 1.06), or in poor outcome (death, vegetative state or severe disability) (OR 1.04, 95% CI 0.90 to 1.21). During the treatment period, fewer patien... | no |
converted_2599 | A bite from the Lone Star Tick Amblyomma americanum, can cause the victim to become allergic to red meat, yes or no? | A recent discovery of an IgE antibody specific to galactose-α-1,3-galactose, which is a carbohydrate abundantly expressed on cells and tissues of beef, pork, and lamb, adds one more tool to aid the clinician in making the appropriate diagnosis. A link has been discovered between the bite of the Lone Star Tick (Amblyomm... | yes |
converted_502 | Is Mycobacterium avium less susceptible to antibiotics than Mycobacterium tuberculosis? | The prevalence of MAC lung infection in two inner city hospitals was four times higher than that of TB., Most patients with combined infection were clinically consistent with MTB and responded to anti MTB treatment alone., The triplex PCR developed by us could be used to detect and differentiate M. tuberculosis, M. avi... | yes |
converted_4482 | Is neurofilament light marker for disease? | sNfL levels during the first demyelinating event of MS are associated with greater impairment of BBB integrity, immune cell extravasation, and brain lesion activity on MRI., Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated the correlat... | yes |
converted_1334 | Is protein Fbw7 a SCF type of E3 ubiquitin ligase? | FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase., However, very few E3 ubiquitin ligases are known to target G-CSFR for ubiquitin-proteasome pathway. Here we identified F-box and WD rep... | yes |
converted_2128 | Is Beta-Thalassemia is associated with a mutation or deletion of the gene that codes for alpha globin? | Beta-thalassemia, one of the most common single-gene disorders, is the result of reduced or absent production of β-globin chains, The beta-thalassemia syndromes are a heterogeneous group of genetic disorders characterized by reduced or absent expression of the beta-globin gene | no |
converted_1367 | Is HER2 active only when it dimerizes? | HER activation is driven by the formation of various dimer complexes between members of this receptor family., rtuzumab is the first humanized monoclonal antibody in a new class of drugs, the HER dimerization inhibitors, approved by the Food and Drug, Pertuzumab is a novel anti-HER2 monoclonal antibody, which blocks HE... | yes |
converted_811 | Is myasthenia gravis associated with osteoporosis? | We performed PVP in 4 patients with generalized MG associated with recent steroid-induced symptomatic VFs. , In this case report, we used tacrolimus to successfully treat a 13-year-old boy with ocular MG who had suffered from severe steroid complications, including a failure of thrive and osteoporosis., INTRODUCTION: ... | yes |
converted_4511 | Is thalidomide used as an immunomodulatory drug nowadays? | Potential immunomodulatory, antiinflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma., In 1990s, however, thalidomide received attention due to the discovery of its anticancer potential derived from antiangiogenic and immu... | yes |
converted_167 | Is CD84 genetically associated with arthritis? | The SNP is predicted to disrupt transcription factor binding site motifs in the 3' UTR of an immune-related gene, CD84, and the allele associated with better response to etanercept was associated with higher CD84 gene expression in peripheral blood mononuclear cells (P = 1 × 10(-11) in 228 non-RA patients and P = 0.004... | yes |
converted_3680 | Is Verubecestat effective for Alzheimer's Disease? | The lack of efficacy of verubecestat in mild-to-moderate AD raises important questions about the timing of intervention with BACE-1 inhibitors, and anti-amyloid therapies in general, in AD treatment. , CONCLUSIONS: Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's... | no |
converted_1267 | Does HER2 under-expression lead to favorable response to trastuzumab? | over-expression of HER2 is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. , In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. Addition of... | no |
converted_2668 | Is the protein pelota a ribosomal rescue factor? | a novel binding partner of the ribosome recycling protein Pelota, n eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation. , In eukaryotes, the protein complex of Pelota (yeast Dom34) and Hbs1 translational GTPase recognizes the stalled ribosome cont... | yes |
converted_2394 | Does erythromycin increase risk of hypertrophic pyloric stenosis? | Post-natal erythromycin exposure and risk of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis., PURPOSE: Macrolide antibiotics, erythromycin, in particular, have been linked to the development of infantile hypertrophic pyloric stenosis (IHPS)., Overall, erythromycin exposure was significa... | yes |
converted_3482 | Is PF-05190457 an inverse agonist of the ghrelin receptor? | Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects., To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults., PF-05190457 is a well-tolerated first-in-cl... | yes |
converted_2434 | Is Tofacitinib effective for Ulcerative Colitis? | Tofacitinib, inhibiting signalling via all Janus kinase family members, was effective in phase 2 and 3 trials in moderate-severe ulcerative colitis., Among them, Janus kinase (JAK) inhibitors seem to have the lead, since tofacitinib has received regulatory approval in 2012 for the treatment of rheumatoid arthritis, and... | yes |
converted_432 | Is it possible to detect survivin protein expression in normal human adult tissues? | Survivin (BIRC5) is one of the members of IAP-family apoptosis inhibitors. The BIRCS gene is expressed in most human embryonic tissues and malignant tumors but not in normal differentiated tissues of adult human., Survivin is an inhibitor of apoptosis that is undetectable in most terminally differentiated normal human ... | no |
converted_213 | Is protein M3/6 a dual specificity phosphatase? | Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus., The results revealed upregulation of dual-specificity phosphatase M3/6 (DUSP8) activity at 4 h of reperfusion in rat hippocampi. , This study examines the molecular mechanism... | yes |
converted_3865 | Is Eflornithine and Sulindac are effective for prevention of progression in Familial Adenomatous Polyposis? | Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis, BACKGROUND: The efficacy and safety of combination therapy with eflornithine and sulindac, as compared with either drug alone, in delaying disease progression in patients with familial adenomatous polyposis are unknown., CONCLUS... | no |
converted_4299 | Does αCGRP have amyloidogenic properties? | αCGRP, another amyloidogenic member of the CGRP family., Therefore, in this work, we investigated the amyloidogenic profile of αCGRP, a 37-residue-long peptide hormone, utilizing both biophysical experimental techniques and Molecular Dynamics simulations. These efforts unravel a novel amyloidogenic member of the CGRP f... | yes |
converted_3217 | Is ustekinumab a polyclonal antibody? | Ustekinumab, a human monoclonal IgG1 antibody targeting the p40-subunit shared by interleukin (IL)12 and IL-23, represents a potential treatment for atopic dermatitis (AD). | no |
converted_2970 | Does allele phasing improve the phylogenetic utility of ultraconserved elements? | Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements., Our empirical analyses of Ultraconserved Element (UCE) locus data collected from the South American hummingbird genus Topaza demonstrate that phased allele sequences carry sufficient phylogenetic information to infer the genetic struc... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.