id stringlengths 11 14 | sentence1 stringlengths 20 192 | sentence2 stringlengths 50 19.2k | label stringclasses 2
values |
|---|---|---|---|
converted_4055 | Is progeria caused by an autosomal recessive gene? | Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic disease that leads to accelerated aging and often premature death caused by cardiovascular complications. , Hutchinson-Gilford progeria syndrome is an autosomal dominant, rare, fatal pediatric segmental premature aging disease., Progeria is sp... | yes |
converted_909 | Does resveratrol reduce cardiac remodeling? | In conclusion, resveratrol attenuated cardiac oxidative damage and left ventricular remodeling and enhanced the decreased expression of SIRT1 in hearts of old rats with emphysema and thus might be a therapeutic modality for cardiac injury complicated in chronic obstructive pulmonary disease (COPD)., In conclusion, resv... | yes |
converted_4344 | Does trimetazidine protect from myocardial injury after percutaneous coronary intervention? | After a median follow-up of 47·5 months (IQR 42·3-53·3), incidence of primary endpoint events was not significantly different between the trimetazidine group (700 [23·3%] patients) and the placebo group (714 [23·7%]; hazard ratio 0·98 [95% CI 0·88-1·09], p=0·73). When analysed individually, there were no significant di... | no |
converted_1626 | Can adult humans be induced to produce fetal hemoglobin? | At the time of birth, HbF accounts for approximately 70% of the total Hb. , whereas in the trace amounts of HbF that is found in the adult it reverses to 40:60 because of a gamma- to beta-globin gene switch, With the increased understanding and discovery of molecular regulators of haemoglobin switching, such as BCL11... | yes |
converted_3884 | Is there high nucleotide diversity in the Drosophila suzukii species? | Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here, we investigate the genetic population str... | yes |
converted_2801 | Is ibudilast effective for multiple sclerosis? | Ibudilast slowed brain atrophy in PPMS and SPMS patients in a multicenter phase 2b study., Ibudilast inhibits several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and toll-like receptor 4 and can cross the blood-brain barrier, with potential salutary effects in progressive multiple scl... | yes |
converted_1615 | Are high-flow nasal cannulae effective for treatment of preterm infants? | The use of high-flow nasal cannulae is an increasingly popular alternative to nasal continuous positive airway pressure (CPAP) for noninvasive respiratory support of very preterm infants (gestational age, <32 weeks) after extubation., The use of high-flow nasal cannulae was noninferior to the use of nasal CPAP, with tr... | yes |
converted_4210 | Is the zelda transcription factor a chromatin remodeller? | ncreasing the number of Zelda binding sites accelerates the kinetics of nuclei transcriptional activation regardless of their transcriptional past, Zelda facilitates transcriptional activation by accumulating in microenvironments where it could accelerate the duration of multiple pre-initiation steps., Zelda acts throu... | yes |
converted_2670 | The TRPM2 gene is associated with development of spontaneous thromboembolism? | TheTransientReceptorPotentialMelastatin 2 (TRPM2) is a member of G protein coupled receptor superfamily and a novel dual-function protein that possesses both ion channel andAdenosine 5'-DiphosPhataseRibose (ADPR) hydrolase function. TRPM2 is involved in Ca2+signaling in various cells as an endogenous redox sensor for o... | no |
converted_1536 | Are OATP1B1 and OATP1B3 associated with bilirubin transport? | OATP1B1 and OATP1B3-mediated transport of bilirubin was confirmed and inhibition was determined for atazanavir, rifampicin, indinavir, amprenavir, cyclosporine, rifamycin SV and saquinavir. , Examples of adaptive nontoxic changes in liver function, which may elevate direct (conjugated) and/or indirect (unconjugated) bi... | yes |
converted_3117 | Are there tools for visualizing and processing long-read sequencing data? | NanoPack: visualizing and processing long-read sequencing data., Here we describe NanoPack, a set of tools developed for visualization and processing of long-read sequencing data from Oxford Nanopore Technologies and Pacific Biosciences.Availability and implementation: The NanoPack tools are written in Python3 and rele... | yes |
converted_3677 | Has the Spanich flu virus been reconstructed? | Reconstruction of the 1918 influenza virus has facilitated considerable advancements in our understanding of this extraordinary pandemic virus., These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights i... | yes |
converted_3768 | Is tocilizumab a tumor necrosis factor inhibitor? | For the first-line bDMARD/tsDMARD, either tumor necrosis factor inhibitors (TNFi), non-TNFi (abatacept, tocilizumab, rituximab), or tsDMARDs, may be considered. | no |
converted_1585 | Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection? | This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. , Although many clinics o... | yes |
converted_2533 | Are paralog genes co-regulated? | Co-regulation of paralog genes in the three-dimensional chromatin architecture., Consequently, paralogs show correlation in gene expression whereby the mechanisms of co-regulation remain unclear. In eukaryotes, genes are regulated in part by distal enhancer elements through looping interactions with gene promoters. The... | yes |
converted_450 | Can SUMO affect calcium homeostasis? | Increasing SUMOylation levels correlated inversely with calcium influx in sensory neurons., CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant., Thus, our results identify a novel role for SUMO modification in CRMP2/CaV2.2 signaling pathway, Moreover, SUMO1 o... | yes |
converted_34 | Do mutations of AKT1 occur in meningiomas? | The recent identification of somatic mutations in components of the SHH-GLI1 and AKT1-MTOR signaling pathways indicates the potential for cross talk of these pathways in the development of meningiomas., A mutation in PIK3CA or AKT1 was found in around 9 % of the cases., AKT1E17K mutations cluster with meningothelial an... | yes |
converted_156 | Is the gene MAOA epigenetically modified by methylation? | Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men., We found significant interindividual differences in methylation status and methylation patterns of the core MAOA promoter. , In the present study, DNA methylation patterns in the MAOA regu... | yes |
converted_3239 | Is TNF-α an activator of pancreatic stellate cells? | TNF-α is the prime factor responsible for the activation of pancreatic stellate cells, Activated PSCs expressed IL-33 in the nucleus, and the expression was increased by IL-1β, TNF-α, PDGF-BB, and IFN-γ, but not TGF-β1. | yes |
converted_1272 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals, The phytochemical, curcumin, has been reported to play many beneficial roles., Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive p... | yes |
converted_1347 | Is the protein product of the cylindromatosis gene (CYLD) a deubiquitinating enzyme? | CYLD was originally identified as a tumor suppressor gene mutated in familial cylindromatosis, an autosomal dominant predisposition to multiple benign neoplasms of the skin known as cylindromas. The CYLD protein is a deubiquitinating enzyme that acts as a negative regulator of NF-κB and JNK signaling through its intera... | yes |
converted_1865 | Is adalimumab effective for hidradenitis suppurativa? | If patient is not improved, then Adalimumab 160 mg at week 0, 80 mg at week 2; then 40 mg subcutaneously weekly should be administered (LOE Ib, SOR A). If improvement occurs then therapy should be maintained as long as HS lesions are present., Reduction in pain scores and improvement in depressive symptoms in patients ... | yes |
converted_4601 | Is Epistaxis associated with dental implant placement? | The overall survival rate of the implants into the sinus cavity was 95.6%, without statistical differences according to the level of penetration. The clinical and radiological complications were 3.4% and 14.8% respectively. The most frequent clinical complication was the epistaxis, , implant placement and protrusion o... | yes |
converted_3555 | Is AZD5153 active in prostate cancer? | AZD5153 Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo., Bromodomain-containing protein 4 (BRD4) overexpression participates in prostate cancer progression by enhancing the transcriptional activity and expression of several key oncogenes. AZD5153 is a novel BRD4 inhibitor.METHODS: Prostate cancer cells were ... | yes |
converted_3058 | Is Miller-Dieker syndrome associated with abnormalities of chromosome 1? | A complete ophthalmic examination is not routinely performed on infants with Miller-Dieker syndrome (MDS, chromosome 17p13.3 microdeletion). , Chromosome microdeletions within 17p13.3 can result in either isolated lissencephaly sequence (ILS) or Miller-Dieker syndrome (MDS). , We report a fetus with lissencephaly diagn... | no |
converted_4119 | Can propofol cause green urine? | Reasons for discontinuing propofol are signs of rhabdomyolysis (92.9%), green urine, elevated liver enzymes (71.4% each) and elevated triglycerides (57.1%)., Propofol-Induced Green Urine in a Patient with Refractory Status Epilepticus., We present the case of a 52-year-old man, who developed green urine following propo... | yes |
converted_3008 | Can Diazepam be beneficial in the treatment of traumatic brain injury? | he present experiment examined the effects of diazepam, a positive modulator at the GABA(A) receptor, on survival and cognitive performance in traumatically brain-injured animals. I | yes |
converted_618 | Does molindone affect body weight? | Mean weight increased by 0.54 kg, and mean body mass index by 0.24 kg/m(2). , A large-scale trial comparing a first-generation antipsychotic (molindone) with newer agents did not find significant differences in treatment response, although the newer antipsychotics were associated with more severe weight gain. , No agen... | yes |
converted_3488 | Does metformin has as an antitumor effect? | an association between metformin and tumorigenesis, Metformin, an antidiabetic drug, inhibits the endometrial cancer cell growth in vivo by improving the insulin resistance;, There is no evidence of antitumor effect of metformin. A possible decrease only for breast, liver and prostate cancer, is compatible with random... | yes |
converted_1283 | Is factor XI deficient in Hemophilia C? | Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic,, Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C), rare case of an acute cerebral aneurysm rupture in a patient with a known factor XI defic... | yes |
converted_1125 | Does smoking increase risk for glioblastoma? | Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility., No relation was observed between glioma risk and smoking (odds ratio = 0.92, 95% confidence interval: 0.77, 1.10; P = 0.37), and there were no interactions for glioma risk of... | no |
converted_2616 | Is Tocilizumab effective for Giant-Cell Arteritis? | Emerging evidence for adjunctive therapy with tocilizumab, methotrexate, aspirin, angiotensin receptor blockers, and statins is encouraging and may lead to a more mainstream role for these therapies among patients with GCA., TNF-α blockers are ineffective in giant cell arteritis, while observational evidence and a pha... | yes |
converted_3683 | Is there an increased risk for meningiomas in childhood leukemia survivors? | Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). , Combined chemotherapy and prophylactic cranial irradiation has improv... | yes |
converted_530 | Is there an association between bruxism and reflux | Rhythmic masticatory muscle activity, including sleep bruxism (SB), can be induced in healthy individuals by experimental esophageal acidification, which plays an important role in the pathogenesis of gastroesophageal reflux disease (GERD). However, no robust evidence supports the association between SB and GERD., Slee... | yes |
converted_2856 | Can exposure to heavy metals like lead(Pb) or cadmium(Cd) cause changes in DNA methylation patterns in Isoetes sinensis? | DNA methylation in endangered plants after exposure to heavy metals, the Isoetes sinensis, an endangered plant, was stressed with three different concentrations of two heavy metals lead (Pb) and cadmium (Cd), The results showed that the DNA methylated profile of I. sinensis was affected by Pb and Cd stress., The propor... | yes |
converted_1377 | Is there a relation between ANP and transcapillary albumin escape? | Thus, in a large ethnically homogeneous cohort of diabetic subjects, our data show: (1) a significant association of C708/T polymorphism with microalbuminuria in long-term diabetes and with both lower plasma ANP levels and widespread albumin leakage, hese results suggest a possible role of PND gene in conferring protec... | yes |
converted_2558 | Is the gene CDKN2A nevogenic? | Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts., Phenotypic characteristics of members of a melanoma prone kindred with a V126D CDKN2A gene mutation were monitored over approximately 15 y., Rare germline mutations in CDKN2A predisp... | yes |
converted_4238 | Does daily atemoya juice intake change the pharmacokinetics of CYP1A2 substrates? | Atemoya juice significantly inhibited CYP1A2 activity in human liver microsomes, but not the activities of CYP2C9 and CYP3A. In spite of this inhibition, preadministration of atemoya had no effect on the pharmacokinetics of phenacetin, a CYP1A2 substrate, in rats. , The results indicate that a daily intake of atemoya w... | no |
converted_1535 | Are immune cells affected in Amyotrophic Lateral Sclerosis? | Therapeutic immunization of mSOD1 mice with a myelin-derived peptide led to CP activation, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocyte-derived macrophages and Foxp3(+) regulatory T cells, and elevation of the neurotrophic factors IGF-1 and GDNF in the diseased spin... | yes |
converted_2216 | Is Hepatic mesenchymal hamartoma usually a malignant tumor? | Mesenchymal hamartoma of the liver (MHL) is a benign and rare hepatic lesion, , Mesenchymal hamartoma of the liver (MHL) is an uncommon benign hepatic tumor typically affecting children under 2 years of age, This review on the pathology of hepatic tumors in childhood, from a personal series of 245 tumors, focuses on in... | no |
converted_1690 | Is the JNK pathway activated during liver regeneration? | analysis of the role of JNK signaling pathway in regulating cell proliferation and apoptosis of rat liver regeneration, paths of JNK signaling pathway regulate cell proliferation and apoptosis in both LR, c-jun is not mandatory for mouse hepatocyte proliferation , Mice lacking c-jun in the liver display impaired regene... | yes |
converted_1901 | Is there any role for Pds5b in cohesion establishment? | Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres., Here, we demonstrate that Pds5 proteins are essential for cohesion establishment by allowing Smc3 acetylation by the cohesin acetyl transferases (CoATs) Esco1/2 and binding of Sororin. While both proteins contribute to telomere and ... | yes |
converted_3782 | Does radiotherapy for cervical cancer increases risk of colon cancer? | After 8 years, the hazard ratio for developing colon cancer was 2.00 (95% CI 1.43-2.80) for women with radiation versus those without radiation treatment., After 35 years of follow-up, the absolute risk of developing colon cancer was 6.5% for those who received radiation versus 2.5% for those without, and 3.7 versus 0.... | yes |
converted_512 | Is vemurafenib effective for hairy-cell leukemia? | CONCLUSIONS: A short oral course of vemurafenib was highly effective in patients with relapsed or refractory hairy-cell leukemia., Our results strongly support and inform the clinical use of BRAF and MEK inhibitors in HCL., The therapeutic approach of vemurafenib in treatment-refractory hairy cell leukemia is promising... | yes |
converted_2105 | Does the word ovine refers to goats? | Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a transmissible lung cancer of sheep that has rarely been found in goats. , In sheep, a bronchiolo-alveolar carcinoma, known as ovine pulmonary carcinoma (OPC), is caused by jaagsiekte sheep retrovirus (JSRV), an exogenou... | no |
converted_3321 | Is there a vaccine for rotavirus? | Safety and Immunogenicity of Pentavalent Rotavirus Vaccine (RV5), This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5), Effectiveness of rotavirus pentavalent vaccine, rotavirus pentavalent vaccine (RotaTeq®) as a sole vaccine, We describe rotavirus vaccine coverage and missed oppor... | yes |
converted_878 | Is dichlorphenamide effective for periodic paralysis? | BACKGROUND AND PURPOSE: Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP)., In one study dichlorphenamide (DCP) vs placebo was tested in two groups of participants: 42 with hypokalemic periodic paralysis (HypoPP) and ... | yes |
converted_3460 | Can radiotherapy cause radiation induced osteosarcoma? | A case of radiation-induced osteosarcoma of the skull presenting as a cutaneous epidermotropic tumor with a short latent period., Radiation-induced sarcoma (RIS) is an unusual but well documented tumor. , We report a case of a 34-year-old female who developed an osteosarcoma of the scalp, over a previous craniotomy sca... | yes |
converted_3493 | Is there a BRCA mutation analysis in the Greek population? | Comprehensive BRCA mutation analysis in the Greek population. Experience from a single clinical diagnostic center., Germline mutations in the BRCA1 and BRCA2 genes are associated with hereditary predisposition to breast and ovarian cancer. Sensitive and accurate detection of BRCA1 and BRCA2 mutations is crucial for per... | yes |
converted_4686 | Is retinol binding protein 4 an adipokine? | Systematic Quantification of Neurotrophic Adipokines RBP4, PEDF, and Clusterin in Human Cerebrospinal Fluid and Serum., Retinol-binding protein 4 (RBP4) is a prominent adipokine i, Fetuin-A and retinol-binding protein 4 (RBP4) are secreted as both hepatokine and adipokine. | yes |
converted_848 | Is there a pharmacogenetic test for trastuzumab? | The clinical need for novel approaches to improve drug therapy derives from the high rate of adverse reactions to drugs and their lack of efficacy in many individuals that may be predicted by pharmacogenetic testing., the assessment of the human epidermal growth factor receptor (HER-2) expression for trastuzumab therap... | yes |
converted_3938 | Is carpal tunnel syndrome a type of nerve entrapment? | Carpal tunnel syndrome (CTS) is a common entrapment neuropathy, often requiring carpal tunnel release (CTR) surgery., Carpal tunnel syndrome (CTS) is an entrapment neuropathy accounting for up to 90% of nerve compression syndromes, Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy in humans. , C... | yes |
converted_1570 | Does neuroglobin has neuroprotective properties in the setting of traumatic brain injury? | Neuroglobin has shown rich neuroprotective effects against cerebral hypoxia, and therefore has the potential to impact outcomes after traumatic brain injury (TBI). , Neuroglobin (Ngb) is proposed to be a neuron-specific, hypoxia-responsive, neuroprotective protein. , CONCLUSION: The increased expression of neuroglobin ... | yes |
converted_2263 | Is scuba diving safe during pregnancy? | Scuba diving is contraindicated., Overall, the women did not conduct enough dives per pregnancy, therefore no significant correlation between diving and fetal abnormalities could be established. These data indicate women are increasingly observing the diving industry recommendation and refraining from diving while preg... | no |
converted_4610 | Do RNA binding Proteins that bind to adenine uridine (AU)-rich elements (AREs) in the 5' untranslated region (UTR) of mRNAs (AU-RBPs) regulate the DNA Damage Response? | We investigated 2 mRNA-binding proteins - HuR and TIAR showing specificity to AU-Rich Element (ARE) sites in 3'UTR of mRNA., Bioinformatics analysis of the human SOD1 mRNA 3' untranslated region (3'UTR) demonstrated the presence of HuD binding adenine-uridine (AU)-rich instability-conferring elements (AREs)., We found... | no |
converted_3414 | Is the protein MCL-1 anti-apoptotic? | increased expression of anti-apoptotic proteins (Bcl-xL, Mcl-1 and XIAP) , repression of anti-apoptotic proteins (Mcl-1, Bcl-xl and XIAP), anti-apoptotic BCL-2 family members, such as BCL-2, BCL-XL or MCL-1 | yes |
converted_3326 | Is there a role for MRPL53 in cancer? | MRPL53, a New Candidate Gene for Orofacial Clefting, Identified Using an eQTL Approach., A valuable approach to understand how individual and population genetic differences can predispose to disease is to assess the impact of genetic variants on cellular functions (e.g., gene expression) of cell and tissue types relate... | no |
converted_933 | Are patients with marfan syndrome at increased risk of arrhythmias? | Marfan syndrome (MFS) is a variable, autosomal-dominant disorder of the connective tissue. In MFS serious ventricular arrhythmias and sudden cardiac death (SCD) can occur., Marfan's patients carry increased risk for cardiac arrhythmias. , Ventricular arrhythmias were present in 21% and were associated with increased le... | yes |
converted_3269 | Is Li–Fraumeni syndrome a rare, autosomal recessive, hereditary disorder that predisposes carriers to cancer development? | Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome inherited in an autosomal dominant fashion that involves a germline mutation of tumor protein 53 (TP53). , Li-Fraumeni syndrome (LFS), a multiorgan cancer predisposition caused by germline TP53 mutations, confers significant cancer risks for young peop... | no |
converted_941 | Do selenoproteins and selenium play a role in prostate cancer prevention? | The selenoprotein-deficient mice exhibited accelerated development of lesions associated with prostate cancer progression, implicating selenoproteins in cancer risk and development and raising the possibility that selenium prevents cancer by modulating the levels of these selenoproteins, Notably and in contrast to prev... | no |
converted_1982 | Is lenvatinib effective for renal cell carcinoma? | However, the combination of lenvatinib, a multitargeted agent that inhibits VEGF as well as FGF receptors, and everolimus demonstrated promising results in a randomized phase II trial. , The FDA has approved the combination of lenvatinib and everolimus to treat advanced or metastatic renal cell carcinoma., Moreover, a ... | yes |
converted_478 | Can vitamin B1 deficiency cause encephalopathy? | Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia, Wernicke encephalopathy (or Wernicke-Korsakoff encephalopathy) is a rarely diagnosed neurological disor... | yes |
converted_1354 | Has the presence of delayed enhancement been documented in athletes performing strenuous exercise? | Atypical findings such as marked cardiac dilation, reduced deformation, or small patches of delayed gadolinium enhancement may be commonly encountered in well-trained athletes, but, at present, the prognostic significance of such findings is unknown. , On CMR, DGE localized to the interventricular septum was identified... | yes |
converted_3035 | Is Lasmiditan effective for migraine? | Amongst the ditans, lasmiditan: (i) fails to constrict human coronary arteries; and (ii) is effective for the acute treatment of migraine in preliminary Phase III clinical trials., Although ongoing phase III clinical trials are needed to confirm its efficacy and safety, lasmiditan might offer an alternative to treat ac... | yes |
converted_4485 | Is nerinetide effective for ischaemic stroke? | 337 (61·4%) of 549 patients with nerinetide and 329 (59·2%) of 556 with placebo achieved an mRS score of 0-2 at 90 days (adjusted risk ratio 1·04, 95% CI 0·96-1·14; p=0·35). Secondary outcomes were similar between groups. , INTERPRETATION: Nerinetide did not improve the proportion of patients achieving good clinical ou... | no |
converted_1929 | Can NADPH oxidase be inhibited by apocynin and diphenylene iodonium? | Ang II treatment also led to a significant increment in intracellular reactive oxygen species generation, which could be fully abolished by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors apocynin or diphenylene iodonium, indicating that Ang II enhanced oxidative stress via a NADPH oxidase-depend... | yes |
converted_4152 | Are there sex differences in oncogenic mutational processes? | Sex differences in oncogenic mutational processes. | yes |
converted_4565 | Is Sotrovimab effective for COVID-19? | It seems that monoclonal antibodies (e.g., low dosage bamlanivimab, baricitinib, imatinib, and sotrovimab) are a better choice for treating severe or non-severe COVID-19 patients. , The Food and Drug Administration has granted emergency use authorization to sotrovimab for the treatment of mild to moderate COVID-19 in p... | yes |
converted_1242 | Is nimodipine recommended for prevention of vasospasm in aneurysmal subarachnoid hemorrhage patients? | This article discusses some of these unresolved issues, including the use of medications such as nimodipine, antifibrinolytics, statins, and magnesium; coiling or clipping for aneurysm securement; and the prevention and treatment of potential complications., The results of this study were as follows: nimodipine demonst... | yes |
converted_1236 | Is there any cross-talk between the Wnt and the Akt pathways? | Our data demonstrate that engaging Wnt signaling at the receptor level by this method leads to necessary crosstalk between multiple signaling pathways including activation of Akt, mTOR, Wnt/β-catenin, PKA/CREB, and inhibition of RhoA/ROCK that substantially increase human β-cell proliferation while maintaining the β-ce... | yes |
converted_3898 | Can saponins be used as adjuvant? | We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants, The purified active fraction of Albizia julibrissin saponin (AJSAF) is an ideal adjuvant candidate, BALB/c mice immunized with subcutaneous injections of the recombinant protein... | yes |
converted_1674 | Has field-programmable gate array (FPGA) technology been used to solve sequence alignment problems? | A linear error model for the raw intensity data and Burrows-Wheeler transform (BWT) based alignment are combined utilizing a Bayesian score function, which is then globally optimized over all possible genomic locations using an efficient branch-and-bound approach. The algorithm has been implemented in soft- and hardwar... | yes |
converted_4321 | Unlike DNA, RNA is not methylated, yes or no? | Mapping the position and quantifying the level of 5-methylcytosine (m5C) as a modification in different types of cellular RNA is an important objective in the field of epitranscriptomics., N6-methyladenosine (m6A) is the most abundant internal modification on messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in ... | no |
converted_2313 | Are there RNAi approaches considered for the treatment of kidney injury? | Herein, we describe ammonium-functionalized carbon nanotube (fCNT)-mediated transport of siRNA selectively and with high efficiency to renal proximal tubule cells in animal models of acute kidney injury (AKI)., fCNT enhanced siRNA delivery to tubule cells compared to siRNA alone and effectively knocked down the express... | yes |
converted_3563 | Are genes that escape X-chromosome inactivation related to mental impairment? | Mutation screening of the MECP2 gene in a large cohort of 613 fragile-X negative patients with mental retardation., The first one, the double nucleotide substitution c.1162_1163delinsTA leading to a premature stop codon (p.Pro388X) was found in a female patient with random X-inactivation, presenting with borderline men... | yes |
converted_2846 | Is phospholipid hydroperoxide glutathione peroxidase a selenoprotein? | Glutathione peroxidase (Gpx1) is the major selenoprotein in most tissues in animals., The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation., the major selenoprotein expressed by germ cells in the testis, the phospholipid hydroperoxide gl... | yes |
converted_3457 | Is Rad4/XPC a DNA damage sensing protein? | Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex., Kinetic gating mechanism of DNA damage recognition by Rad4/XPC., These findings indicate that the lesions recognized by Rad4/XPC thermodynamically destabilize the Watson-Crick double helix in a manner that facilitates t... | yes |
converted_3931 | Is cadherin a plasma membrane marker? | the plasma membrane-bound E-cadherin protein, VE-cadherin protein levels were also increased in the plasma membrane fraction. , recycling of VE-cadherin to the plasma membrane,, E-cadherin, a central component of the adherens junction (AJ), is a single-pass transmembrane protein | yes |
converted_1430 | Is the UGT1A1*28 polymorphism associated with irinotecan response in Caucasians? | These variants are associated with greater risk of serious toxicity., Homozygous carriers of UGT1A1*28 as well as those with additional UGT1A variants can suffer from severe irinotecan toxicity | yes |
converted_3151 | Can oleuropein aglycone interfere with amyloid aggregation? | Oleuropein, a phenolic secoiroid glycoside, is the main polyphenol in the olive oil. It has been reported that the aglycone form of Oleuropein (OleA) interferes in vitro and in vivo with amyloid aggregation of a number of proteins/peptides involved in amyloid, particularly neurodegenerative, diseases avoiding the growt... | yes |
converted_169 | Are there any specific antidotes for rivaroxaban? | Novel oral anticoagulants (NOACs)--apixaban, dabigatran, and rivaroxaban--have a significantly smaller risk of intracerebral hemorrhage (ICH). However, two facts make this situation complicated: First, the risk of hematoma expansion is unknown for NOACs. Second, there is no specific antidote for neither of the NOACs., ... | no |
converted_334 | Is exome sequencing efficient for the detection of germline mutations? | Whole exome sequencing is an efficient and sensitive method for detection of germline mutations in patients with phaeochromcytomas and paragangliomas, Whole exome sequencing is sensitive, rapid and efficient for detection of PCC/PGL germline mutations., These results from deep sequencing demonstrate a higher mutational... | yes |
converted_3167 | Can miR-122 target RUNX2? | MiR-122 functions as a tumor suppressor by inhibiting proliferation and inducing apoptosis, which is achieved by directly targeting RUNX2. | yes |
converted_3804 | Have the rotavirus vaccines changed the predominant rotavirus genotypes? | This study describes the distribution and diversity of rotavirus genotypes before and after rotavirus vaccine introduction into the Australian NIP., G1P[8] was the dominant genotype nationally in the prevaccine era (1995-2006). Following vaccine introduction (2007-2015), greater genotype diversity was observed with flu... | yes |
converted_2797 | Is selenocysteine an aminoacid? | Selenocysteine (Sec), a rare genetically encoded amino acid with unusual chemical properties, is of great interest for protein engineering., Selenocysteine (SeC) is a naturally available Se-containing amino acid that displays splendid anticancer activities against several human tumors. | yes |
converted_1302 | Does thyroid hormone signaling affect microRNAs expression in the heart? | e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a., On the other hand, T₃ treatment increased miR-35... | yes |
converted_4236 | Is SMOC2 expressed during wound healing? | All three fibroblast populations were PDGFRα+/CD34 + but were distinct in their expression of Ngfr/Spon2/Angptl7 (F1), Cxcl14/Smoc2/Rgs2 (F2), and Clec3b/Col14a1/Mmp3 (F3), with potential functions in the regulation of immune responses, response to wounding, and organization of extracellular matrix, respectively., Defi... | yes |
converted_1044 | Does Chromatin Immunoprecipitation (ChIP) show a bias for highly expressed loci? | However, several issues in the processing and analysis of ChIP-chip data have not been resolved fully, including the effect of background (mock control) subtraction and normalization within and across arrays, Proper normalization is essential for ChIP-chip experiments. The proposed normalization technique can correct ... | yes |
converted_3674 | Thymoquinone is ineffective against radiation induced enteritis, yes or no? | n this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. , In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation., TQ... | no |
converted_2330 | Is DNA methylation correlated with nucleosome occupancy? | Here I show that CpG islands were associated not only with methylation-free promoters but also with nucleosome-free promoters., Nucleosome-free regions were observed only in promoters containing a CpG island, In contrast to the methylation-and nucleosome-free states of CpG-island promoters, exons were densely methylate... | yes |
converted_3 | Are long non coding RNAs spliced? | Our analyses indicate that lncRNAs are generated through pathways similar to that of protein-coding genes, with similar histone-modification profiles, splicing signals, and exon/intron lengths., For alternative exons and long noncoding RNAs, splicing tends to occur later, and the latter might remain unspliced in some c... | yes |
converted_891 | Is NOD1 activated in inflammation? | Nod1 and Nod2 control bacterial infections and inflammation, The Nod proteins Nod1 and Nod2 are two NLR family members that trigger immune defense in response to bacterial peptidoglycan, Nod proteins fight off bacterial infections by stimulating proinflammatory signaling and cytokine networks and by inducing antimicrob... | yes |
converted_3144 | Is the protein Asporin related to disease? | Accumulating evidence demonstrates the involvement of asporin in OA pathogenesis., Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer., Asporin has been implicated as an oncogene in various types of human cancers; , These results sugg... | yes |
converted_3037 | Are there graph kernel libraries available implemented in JAVA? | graphkernels: R and Python packages for graph comparison., Measuring the similarity of graphs is a fundamental step in the analysis of graph-structured data, which is omnipresent in computational biology. Graph kernels have been proposed as a powerful and efficient approach to this problem of graph comparison. Here we ... | no |
converted_665 | Has overexpression of sirtuins been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)? | In addition, Sir2 overexpression prevents Rif1 deletion from disrupting Sir2 at IGS1 and shortening lifespan. , Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals., Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budd... | yes |
converted_1182 | Is macroautophagy a selective degradation process? | Selective autophagy, Macroautophagy (autophagy) is a bulk degradation system for cytoplasmic components and is ubiquitously found in eukaryotic cells, Here we show that selective autophagy downregulates Ty1 transposition, We propose that selective autophagy safeguards genome integrity against excessive insertional muta... | yes |
converted_1948 | Do IEG create a ripple effect of transcription? | Rapid induction of immediate-early genes (IEGs) in response to growth factor stimulations is accompanied by co-upregulation of their neighbouring genes., Even in surrounding intergenic regions, transcriptional activation took place at the same time. , Here we show that intensive transcription at one locus frequently sp... | yes |
converted_3449 | Can Flotillin be used as exosomal marker? | Flotillin 1 and tumor susceptibility gene 101 (TSG101), two exosomal marker proteins, , expressed exosomal marker tumor susceptibility gene (TSG) 101 and flotillin (Flot) 1. | yes |
converted_876 | Can fetal aneuploidy be detected with non-invasive prenatal testing? | Non-invasive prenatal testing with cell-free DNA: US physician attitudes toward implementation in clinical practice., The aim of this study was to assess awareness, potential adoption, and current utilization of non-invasive prenatal testing (NIPT) analysis for common fetal aneuploidies among obstetricians, Cell-free D... | yes |
converted_4530 | Are functional tests a good biomarker for Duchenne Muscular Dystrophy? | North Star Ambulatory Assessment is practical and reliable., allow assessment of high-functioning boys with Duchenne muscular dystrophy., agnosis and tracking of symptom progression of DMD usually relies on creatine kinase tests, evaluation of patient performance in various ambulatory assessments, and detection of dyst... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.