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values | paper_id stringlengths 10 26 | doi stringlengths 15 34 ⌀ | version int64 1 6 | title stringlengths 22 201 | authors listlengths 1 43 | license stringclasses 2
values | source_url stringlengths 35 60 | published timestamp[s]date 2021-03-03 00:00:00 2026-07-16 00:00:00 | blocks listlengths 19 529 |
|---|---|---|---|---|---|---|---|---|---|
biorxiv | 10.64898/2026.04.28.721434 | 10.64898/2026.04.28.721434 | 1 | Engulfment by brain macrophages in a short-lived vertebrate | [
"Nagvekar, R.",
"Pogson, A. N.",
"Kalakuntla, P. R.",
"Barr, H. J.",
"Martinez Jaimes, A. M.",
"Perry, S. V.",
"Costa, E. K.",
"Chen, J.",
"Boos, F.",
"Navarro Negredo, P.",
"Seeker, L. A.",
"Jaggard, J. B.",
"Barajas, R.",
"Mourrain, P.",
"Priya Singh, P.",
"Quake, S. R.",
"Wyss-Cor... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.28.721434v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The vertebrate brain uses varied strategies to clear extracellular material such as extracellular matrix and aggregation-prone proteins 1 – 3 . Engulfment by specialized cells 4 – 7 – including macrophages ... |
biorxiv | 10.64898/2026.04.27.721197 | 10.64898/2026.04.27.721197 | 1 | TRPV1 antagonism occurs through diverse structural mechanisms | [
"Lopez, K. E.",
"Paduda, A. D.",
"Derrick, M. J.",
"Van Horn, W. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721197v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Chronic pain is a pervasive global health problem 1 . In the United States, chronic pain is estimated to affect 20.9% of adults (∼51.6 million people), and opioids remain among the most effective analgesics... |
biorxiv | 10.64898/2026.04.27.721125 | 10.64898/2026.04.27.721125 | 2 | Constitutive and inducible fibrosis explain immune variation among threespine stickleback populations | [
"Choi, E.",
"Flanagan, B. A.",
"Alexander, H.",
"Berini, J.",
"Yeung, A.",
"Wolf, C. J.",
"Watts, V.",
"Vaziri, G.",
"Vargas, N.",
"Szajada, C.",
"Steffen, P.",
"Srinivas, I.",
"Shahid, M.",
"Santacruz, A.",
"Rochon, K.",
"Rippin, L.",
"Redfield, E.",
"Polard, E.",
"Patterson, C.... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721125v2 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Genetic variation in immunity provides the raw material for host defense evolution and contributes to variation in parasite susceptibility among individuals and populations ( Brodin & Davis, 2016 ; Fumagall... |
biorxiv | 10.64898/2026.04.27.721108 | 10.64898/2026.04.27.721108 | 1 | Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned | [
"Gritz, S.",
"Milstein, A. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721108v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "During spatial learning, excitatory neurons in the hippocampus called “place cells” develop location-specific firing patterns called “place fields,” which are thought to provide a cellular substrate for spa... |
biorxiv | 10.64898/2026.04.27.721072 | 10.64898/2026.04.27.721072 | 1 | Coordinated subpocket engagement underlies nitazene potency at the μ-opioid receptor. | [
"Robinson, M. J.",
"Chen, L.",
"Thakur, A.",
"Lee, K.-H.",
"Shi, L."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721072v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The “opioid epidemic” is a public health crisis characterized by widespread misuse of opioids and rising overdose deaths. 1 The epidemic’s third wave, which began around 2013 with the emergence of illicitly... |
biorxiv | 10.64898/2026.04.27.720990 | 10.64898/2026.04.27.720990 | 1 | Severe malarial anaemia is associated with parasite enrichment and host alterations in the bone marrow | [
"Marti, M.",
"Da Silva Filho, J. L.",
"Meibalan, E.",
"Gupta, H.",
"Beraldi, D.",
"Bopp, S.",
"Wirth, D. F.",
"Moxon, C. A.",
"Macete, E.",
"Moraleda, C.",
"Aguilar, R.",
"Mayor, A.",
"Milner, D.",
"Menendez, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.720990v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "Malaria remains a major global health issue, with over 200 million new infections and about half million fatal cases each year. Most of the fatal cases are in sub-Saharan Africa, in particular in children bel... |
biorxiv | 10.64898/2026.04.26.720968 | 10.64898/2026.04.26.720968 | 1 | Reproductive isolation emerges from coordinated barriers during mating system divergence in plants | [
"Garcia Munoz, A.",
"Ferron, C.",
"Olivieri, E.",
"Abdelaziz, M.",
"Munoz-Pajares, A. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720968v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The speciation process relies on the accumulation of genetic differences among populations, ultimately driven by the emergence of reproductive barriers that reduce or prevent gene flow between them ( Mayr, ... |
biorxiv | 10.64898/2026.04.26.720944 | 10.64898/2026.04.26.720944 | 1 | Early Vertebrates Were Not Slow: Rapid Life Histories in Devonian Agnathans | [
"Okabe, N.",
"Pauly, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720944v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Life history strategies, including growth rate, timing of maturation, and population turnover, form a fundamental link connecting ontogeny, population dynamics, and ecosystem structure in vertebrates ( Aren... |
biorxiv | 10.64898/2026.04.26.720932 | 10.64898/2026.04.26.720932 | 1 | Spatial Single-Cell Proteomics Reveals Molecular Trajectories Of Tangle-Bearing Neurons In Alzheimer's Disease | [
"Foiani, M. S.",
"Bourdenx, M.",
"Lukas, K.",
"Raja, N. S.",
"Angela, Y.",
"Hannah, D.",
"Saisha, P.",
"Luiza, D. S.",
"Ludovico, M.",
"Zane, J.",
"Fabian, C.",
"Karen, D. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720932v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "Alzheimer’s disease (AD), the most common cause of dementia, is characterized by the extracellular accumulation of amyloid-β plaques and intraneuronal aggregates of hyperphosphorylated tau into neurofibrillary tang... |
biorxiv | 10.64898/2026.04.26.720929 | 10.64898/2026.04.26.720929 | 1 | Focused ultrasound alters neural time irreversibility independently of response amplitude | [
"Dmochowski, J. P.",
"Wolpert, D. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720929v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive approach for modulating deep brain activity with millimetre-scale spatial precision and access to targets that are difficult to... |
biorxiv | 10.64898/2026.04.26.720921 | 10.64898/2026.04.26.720921 | 1 | Diagnosing protein sequence search in the era of language models | [
"Zhou, H.",
"Yang, Y.",
"Lu, Y. Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720921v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Protein sequence search is a foundational operation in biological research, supporting tasks that range from homology detection and functional annotation to evolutionary analysis and structure prediction [ ... |
biorxiv | 10.64898/2026.04.26.720914 | 10.64898/2026.04.26.720914 | 1 | CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens | [
"Halvorsen, A. T.",
"Narayanan, A.",
"Link, G. M.",
"Wagner, T. J.",
"Waterman, A. K.",
"Cowen, M. H.",
"Tonn Eisinger, K. R.",
"Glickfeld, L. L.",
"West, A. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720914v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Arc (activity-regulated cytoskeleton-associated protein) transcription is rapidly and transiently induced in both developing and adult neurons by neuronal activity ( Lyford et al., 1995 ). The observation t... |
biorxiv | 10.64898/2026.04.26.720911 | 10.64898/2026.04.26.720911 | 1 | A Bayesian approach for identifying similar transcript dynamics using curve registration | [
"Kristianingsih, R.",
"Calderwood, A.",
"Sidhu, G.",
"Woodhouse, S.",
"Woolfenden, H. C.",
"Kurup, S.",
"Wells, R.",
"Morris, R. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720911v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Analysis of gene expression over time can shed light on the inner workings of cells and provide insights into transcriptional regulation and gene function. Variation in gene expression can lead to phenotypi... |
biorxiv | 10.64898/2026.04.26.720906 | 10.64898/2026.04.26.720906 | 1 | Selection favors context-dependent bias in altruism | [
"Bavik, L. M.",
"Mehta, R. S.",
"Weissman, D. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720906v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "One lesser-discussed aspect of Hamilton’s rule for the evolution of social traits ( r > c/b ) is that relatedness is not only a function of the genetic distance between an actor and recipient, but a functio... |
biorxiv | 10.64898/2026.04.26.720902 | 10.64898/2026.04.26.720902 | 1 | Pharmacodynamic profiles inform systematization, efficacy and whole-brain drug distribution profiles in 18 antidepressants | [
"Hänisch, B.",
"Valk, S. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720902v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Depressive disorders are major contributors to the global burden of disease ( 1 ), and antidepressant medication is an important constituent of guideline-based care for major depressive disorder. Most antid... |
biorxiv | 10.64898/2026.04.26.720864 | 10.64898/2026.04.26.720864 | 1 | Post-GWAS functional annotation of the RPTOR locus identifies rs12950541 as a candidate regulatory variant for type 2 diabetes and metabolic traits | [
"Gallardo-Blanco, H. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720864v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Type 2 diabetes mellitus (T2D) represents one of the most significant global health challenges of the 21st century, affecting an estimated 537 million adults worldwide. The pathophysiology is multifactorial... |
biorxiv | 10.64898/2026.04.26.720863 | 10.64898/2026.04.26.720863 | 1 | Atlantic and Indo-Pacific separation in Palythoa sibling species: phylogenomic analyses using ultraconserved elements | [
"Hansen, L. A. J.",
"Santos, M. E. A.",
"Kise, H.",
"Zamora-Jordan, N.",
"Reimer, J. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720863v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Zoantharians (Cnidaria; Anthozoa; Zoantharia) occupy diverse marine habitats, including shallow tropical coral reefs, intertidal flats, and mesophotic environments, often colonising biotic substrates throug... |
biorxiv | 10.64898/2026.04.26.720725 | 10.64898/2026.04.26.720725 | 1 | Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination | [
"Moser, B. A.",
"Points, M.",
"Agrawal, S.",
"Didier, A. C.",
"Mennie, A. K.",
"Lim, C. J.",
"Xu, Y.-j.",
"Nakamura, T. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720725v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Telomeres, the ends of linear chromosomes, consist of repetitive double-stranded DNA (dsDNA) terminating in a 3’ single-stranded G-rich overhang. Telomerase, composed of the catalytic subunit TERT and an as... |
biorxiv | 10.64898/2026.04.25.720849 | 10.64898/2026.04.25.720849 | 1 | Adenoviral-mediated gene transfer into the scala media of the mouse cochlea in vivo | [
"Iguchi, F.",
"Bratt, D.",
"Xiao, M.",
"Erdman, A. D.",
"Sekijima, A. E.",
"Hume, C. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720849v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Gene therapy may provide a way to restore function to patients with hearing and balance disorders. Experimental gene delivery to the inner ear in mammals was first reported in 1996 ( Raphael et al., 1996 ).... |
biorxiv | 10.64898/2026.04.25.720827 | 10.64898/2026.04.25.720827 | 1 | Glucocorticoid - endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution | [
"Coutens, B.",
"Bouchet, C. A.",
"Gvon, I.",
"Patti, L. C.",
"De Anda Gamboa, C. M.",
"Jewett, D. C.",
"Klawitter, J.",
"Klawitter, J.",
"Heinricher, M. M.",
"Ingram, S. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720827v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cannabis has been used to manage pain for millennia, but the current push to legalize marijuana and other cannabinoids has increased use substantially in the past 5 years [ 1 ]. Randomized, controlled clini... |
biorxiv | 10.64898/2026.04.25.720815 | 10.64898/2026.04.25.720815 | 1 | Allogeneic CRISPR-Engineered CAR-T Cells Drive Potent Antitumor Activity in Solid Tumors | [
"Huo, M.",
"Li, D.",
"Li, N.",
"Quan, A.",
"Liang, T.",
"Henderson, D.",
"Sagert, J.",
"Pharm, M.",
"Hanley, L.",
"Maeng, K.",
"Eule, M.",
"Ho, M."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720815v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape for hematologic malignancies. 1 However, the clinical success of conventional CAR-T therapies has not translated effect... |
biorxiv | 10.64898/2026.04.25.720801 | 10.64898/2026.04.25.720801 | 1 | Getting a head: Evidence for a conserved anterior head patterning gene network in arthropods | [
"Cocker, B. M. J.",
"Peel, A. D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720801v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Classically referred to as “The arthropod head problem” or the “Endless dispute”, our understanding of arthropod head evolution has progressed, but some key aspects remain unresolved ( 1 – 3 ). In particula... |
biorxiv | 10.64898/2026.04.25.720782 | 10.64898/2026.04.25.720782 | 1 | Deterministic retrieval recovers biomedical associations lost by language models | [
"Halder, A.",
"Singh, M.",
"Kesarwani, R.",
"Mathew, B.",
"Bhattacharya, N.",
"Chikhaliya, O.",
"Motwani, D.",
"Peela, S. C. M.",
"Samanta, S.",
"Muddemmanavar, P.",
"Farooq, M.",
"Ahuja, G.",
"Sengupta, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720782v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "How many biomedical associations do conversational retrieval systems miss? The question matters because missing associations can compromise downstream analyses in drug discovery and translational research 1 , yet t... |
biorxiv | 10.64898/2026.04.25.720622 | 10.64898/2026.04.25.720622 | 1 | More Efficient Walking via Temporal and Spatial Energy Transfer in a Passive Biarticular Exosuit | [
"Firouzi, V.",
"Ahmadi, A.",
"Davoodi, A.",
"Haufe, D.",
"Seyfarth, A.",
"Sawicki, G. S.",
"Sharbafi, M. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720622v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Biological systems feature embodied musculoskeletal structures integrated with neural control architectures enabling emergent agile, stable, and economical locomotion that engineered locomotor systems strug... |
biorxiv | 10.64898/2026.04.24.720674 | 10.64898/2026.04.24.720674 | 2 | Immunization With Herpes Simplex Virus Nanoparticles Targeting Both Attachment and Fusion Protect Against Infection | [
"Maciorowski, D.",
"Vostal, A. C.",
"Bu, W.",
"Pytel, I. S.",
"Antonioli-Schmit, S.",
"Zhu, J.",
"Hoyt, F. H.",
"Lei, H.",
"Liu, G.",
"Kaiser, K.",
"Herbert, R.",
"Dowdell, K. C.",
"Schiller, J. T.",
"Wang, K.",
"Howarth, M. R.",
"Cohen, J. I."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720674v2 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Prevention of herpes simplex virus type 2 (HSV-2) disease is a global health priority 1 , with an estimated 520 million people affected worldwide, with twice as many women infected as men 1 , 2 . During pri... |
biorxiv | 10.64898/2026.04.24.720642 | 10.64898/2026.04.24.720642 | 2 | Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease | [
"Lin, Z.",
"Parker, J.",
"Nithianandam, V.",
"Mathivanan, S.",
"Wang, T.",
"Liao, Z.",
"Simmons, S. K.",
"Tuncali, I.",
"Adiconis, X.",
"Haywood, N.",
"Weykopf, B.",
"Teng, X.",
"Sharma, M.",
"Yuan, J.",
"Baecher-Allan, C.",
"Dong, X.",
"Beach, T. G.",
"Serrano, G. E.",
"Levin, J... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720642v2 | 2026-04-24T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Neuronal alpha-synuclein diseases 1 , 2 —Parkinson’s disease (PD) and Lewy body disease—affect more than 15 million people worldwide 3 , 4 . Their pathological hallmark is the Lewy body, an intraneuronal ag... |
biorxiv | 10.64898/2026.04.24.720601 | 10.64898/2026.04.24.720601 | 1 | CMV Replication Drives IFNγ-Mediated Sensitization of AML Cells to Cytotoxic Killing Through the NKG2C-HLA-E Axis | [
"Moskorz, W.",
"Cadeddu, R. P.",
"Uhrberg, M.",
"Jäger, P. S.",
"Grutza, R.",
"Grothmann, R.",
"Trilling, M.",
"Dietrich, S.",
"Cosmovici, C.",
"Haas, R.",
"Timm, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720601v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cytomegalovirus (CMV) infection is highly prevalent especially in older adults, a population with an increased risk for hematologic malignancies. Among patients undergoing hematopoietic stem cell transplant... |
biorxiv | 10.64898/2026.04.22.720240 | 10.64898/2026.04.22.720240 | 1 | Teleport-Stabilized Quantum-Walk Ranking in Near-Tie Neoantigen Regimes | [
"GRIGORIADIS, I.",
"Emmanouilides, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720240v1 | 2026-04-29T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Selecting a manufacturable neoantigen set for a personalized cancer vaccine is a constrained, high-leverage decision: per patient, thousands of mutant peptide candidates are enumerated, but only a small top... |
biorxiv | 10.64898/2026.04.22.720196 | 10.64898/2026.04.22.720196 | 2 | Multi-Modal Deep Learning Integrates Spatial Topologies and Sequential Motifs to Identify Class I HDAC Inhibitors as Pan-Cancer Therapeutics | [
"Tong, S.",
"Zhang, W.",
"Ji, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.22.720196v2 | 2026-04-25T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "I ntroduction"
},
{
"type": "para",
"text": "Cancer is an inherently complex, polygenic, and highly dynamic disease driven by a multitude of genomic, transcriptomic, and epigenetic alterations [ 1 ]. Over the past decade, landmark international initi... |
biorxiv | 10.64898/2026.04.15.718635 | 10.64898/2026.04.15.718635 | 2 | Evolution and adaptations of the seminal proteome in an insect with traumatic insemination | [
"Garlovsky, M. D.",
"Otti, O.",
"Reinhardt, K.",
"Karr, T. L."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.15.718635v2 | 2026-04-18T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The proteomic composition of sperm and seminal fluid is central to fertility and fitness ( Snook 2005 ; Perry et al. 2013 ). Proteins are a major component of gametes, in large part dictating spermatozoa fo... |
biorxiv | 10.64898/2026.04.13.718236 | 10.64898/2026.04.13.718236 | 2 | Environment and host infection history jointly predict disease risk in a multi-pathogen system | [
"Scott, C. B.",
"Cleary, S.",
"Grunberg, R.",
"Halliday, F. W.",
"Joyner, B.",
"O'Keeffe, K.",
"Stiver, I.",
"Mitchell, C. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.13.718236v2 | 2026-04-15T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The success of pathogen transmission is jointly shaped by both abiotic environmental factors and the biotic context. During transmission, many pathogens are exposed to environmental conditions, such as temp... |
biorxiv | 10.64898/2026.04.06.716678 | 10.64898/2026.04.06.716678 | 2 | Structural principles of transcriptional collisions | [
"Watters, J. W.",
"Mueller, A. U.",
"Ju, X.",
"Chuquimarca, S. J.",
"Ye, H. J.",
"Darst, S. A.",
"Alushin, G. M.",
"Liu, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.06.716678v2 | 2026-04-06T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The genome has been described as a molecular highway where the macromolecular machines that carry out fundamental central dogma processes (e.g. replication and transcription) function in a densely crowded e... |
biorxiv | 10.64898/2025.12.12.694075 | 10.64898/2025.12.12.694075 | 2 | A 0.6-meter resolution canopy height model for the contiguous United States | [
"Morford, S. L.",
"Allred, B. W.",
"Coons, S. P.",
"Marcozzi, A. A.",
"McCord, S. E.",
"Smith, J. T.",
"Naugle, D. E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2025.12.12.694075v2 | 2025-12-16T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background & Summary"
},
{
"type": "para",
"text": "Accurate characterization of ecosystem structure is essential for addressing foundational questions in ecology, carbon science, and land management 1 – 5 . While airborne and terrestrial lidar syste... |
biorxiv | 10.1101/2025.09.29.679204 | 10.1101/2025.09.29.679204 | 2 | Fast and haplotype-aware assembly of high-fidelity reads based on MSR sketching: the Alice assembler | [
"Faure, R.",
"Hilaire, B.",
"Flot, J.-F.",
"Lavenier, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.29.679204v2 | 2025-09-30T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "With the rise of high-throughput sequencing, genomic experiments have been producing vast amounts of data, far outpacing the growth of computing power predicted by Moore’s law [ 12 ]. It is now common for a s... |
biorxiv | 10.1101/2025.09.18.675430 | 10.1101/2025.09.18.675430 | 2 | Morphological heterogeneity of human astrocytes in cerebral organoids | [
"Szederkenyi, K.",
"Au, A.",
"Attisano, L.",
"Oheim, M.",
"Yip, C. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.18.675430v2 | 2025-09-18T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The macro- and micro-anatomical differences between the human and rodent brain are well established ( 3 , 4 ). However, due to restricted access to healthy human brain tissue, rodents remain the predominant... |
biorxiv | 10.1101/2025.09.17.676269 | 10.1101/2025.09.17.676269 | 2 | Phase separation determines treadmilling-like movement ofactin bundles | [
"Nast-Kolb, T.",
"Nettuno, B.",
"Toffenetti, D.",
"Striebel, M.",
"Frey, E.",
"Bausch, A. R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.17.676269v2 | 2025-09-18T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The ability of cells to constantly reshape for movement, division, and interaction with their environment critically relies on the ability of cytoskeletal filaments to build dynamically reorganizing higher-... |
biorxiv | 10.1101/2025.09.09.675061 | 10.1101/2025.09.09.675061 | 2 | Bidirectional Crosstalk Between Bladder Cancer Cells and Normal Fibroblasts Drives Phenotypic Reprogramming and Modulates Chemosensitivity | [
"Gao, J.",
"Ji, C. X.",
"Ren, C.",
"Hines, J.",
"Stride, E.",
"Bryan, R. T.",
"Rohn, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.09.09.675061v2 | 2025-09-14T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bladder cancer is among the most common malignancies worldwide, with non-muscle-invasive disease (NMIBC) accounting for 75% of diagnoses [ 1 ]. Despite standard-of-care transurethral resection, BCG immunoth... |
biorxiv | 10.1101/2025.08.16.670680 | 10.1101/2025.08.16.670680 | 2 | The centriculum, a membrane reticulum that surrounds C. elegans centrosomes, may serve as a microtubule filter | [
"Maheshwari, R.",
"Rahman, M. M.",
"Ruddick, A.",
"Drey, S.",
"Mirabello, R. S.",
"Cohen-Fix, O."
] | CC0-1.0 | https://www.biorxiv.org/content/10.1101/2025.08.16.670680v2 | 2025-08-18T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Centrosomes are cytoplasmic structures that nucleate microtubules, polymers made of α- and β-tubulin heterodimers that form linear, side-by-side, protofilaments, creating a hollow microtubule tube (reviewed... |
biorxiv | 10.1101/2025.07.17.665450 | 10.1101/2025.07.17.665450 | 3 | Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer | [
"Kitoi, M.",
"Gitau, J.",
"Kinyori, G.",
"Mwangi, K.",
"Ngonga, F.",
"Makokha, F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.07.17.665450v3 | 2025-07-22T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Breast cancer remains a major global health challenge, with approximately 20 million new cancer cases reported in 2022, of which breast cancer accounted for 11.6% and ranked as the second most common malign... |
biorxiv | 10.1101/2024.02.12.579892 | 10.1101/2024.02.12.579892 | 4 | Zapit: Open Source Laser-Scanning Photostimulation For Neuroscience | [
"Lohse, M.",
"Gauld, O. M.",
"Quigley, M. T.",
"Masood, A.",
"Bao, C.",
"Li, J.",
"Miska, N. J.",
"Nabbefeld, G.",
"Pajot-Moric, Q.",
"Townsend, S.",
"Vincent, P.",
"Yang, A. Y.",
"Zervogiannis, N.",
"Akrami, A.",
"Duan, C. A.",
"Erlich, J. C.",
"Hofer, S. B.",
"Mrsic-Flogel, T. D.... | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.02.12.579892v4 | 2024-02-12T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Optogenetics is now the principal experimental tool for manipulating neural activity in systems neuroscience due to its high temporal precision, non-invasive options, reversibility, and genetically and spat... |
biorxiv | 10.1101/2024.02.09.579615 | 10.1101/2024.02.09.579615 | 3 | The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles | [
"Boudjema, A.-R.",
"Balague, R.",
"Jewett, C. E.",
"Serizay, J.",
"LoMastro, G. M.",
"Mercy, O.",
"Al Jord, A.",
"Faucourt, M.",
"Schaeffer, A.",
"Nous, C.",
"Delgehyr, N.",
"Holland, A. J.",
"Spassky, N.",
"Meunier, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.02.09.579615v3 | 2024-02-12T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Centriole amplification is a characteristic of multiciliated cell (MCC) differentiation, necessary for the nucleation of dozens of motile cilia that propel physiological fluids in the brain, the respiratory... |
biorxiv | 10.1101/2022.05.05.490401 | 10.1101/2022.05.05.490401 | 4 | Resetting of H3K4me2 during mammalian parental-to-zygote transition | [
"Wang, C.",
"Li, Y.",
"Wang, Y.",
"Shi, Y.",
"Meng, X.",
"Li, W.",
"Guo, J.",
"Hu, K.",
"chen, H.",
"Xu, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2022.05.05.490401v4 | 2022-05-05T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Drastic epigenetic reprogramming occurs during early mammalian embryo development. Epigenetic marks, such as DNA methylation and histone modification, play important roles in the epigenome reprogramming pro... |
biorxiv | 10.64898/2026.04.28.721328 | 10.64898/2026.04.28.721328 | 1 | Distinct virus-derived circular RNA molecule influences host response during SARS-CoV-2 infection | [
"Grossi-Soyster, E. N.",
"Gullberg, R. C.",
"Rustagi, A.",
"Lee, J. S.",
"Blish, C. A.",
"Cherry, S.",
"Salzman, J.",
"Sarnow, P."
] | CC0-1.0 | https://www.biorxiv.org/content/10.64898/2026.04.28.721328v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Since emerging in 2019[ 1 ], Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has exemplified rapid evolution and viral persistence resulting in continued global spread. SARS-CoV-2 is a positive... |
biorxiv | 10.64898/2026.04.27.721221 | 10.64898/2026.04.27.721221 | 1 | Coenzyme A is a redox sensing cofactor for malic enzyme 2 regulating oxidative stress and mitochondrial metabolism | [
"Chen, W.",
"Nelson, O. D.",
"Li, X.",
"Zhang, M.",
"Lu, X.",
"Yu, T.",
"Yao, C.-H.",
"Zhang, S.",
"Zhang, Y.",
"Francisco, A.",
"Ahn, B.",
"Lundberg, E.",
"Song, M.",
"Rahbani, J. F.",
"Chen, Z.",
"Lin, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721221v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Coenzyme A (CoA), discovered by Fritz Lipmann in the 1940s 1 , is a central metabolic cofactor that carries acyl groups via a high-energy thioester bond. It is required for mitochondrial energy production, ... |
biorxiv | 10.64898/2026.04.27.721184 | 10.64898/2026.04.27.721184 | 1 | Protein Function Prediction with Pretrained ProtT5 Embeddings and Gradient Boosting | [
"Appel, J.",
"Butcher, N."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721184v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Accurately annotating protein function is essential for understanding biological systems, yet experimental characterization remains costly and incomplete. As a result, large public databases such as the Gen... |
biorxiv | 10.64898/2026.04.27.721109 | 10.64898/2026.04.27.721109 | 1 | Charged agar surfaces affect E. coli biofilm properties by balancing curli amyloid quantity and quality | [
"Siri, M.",
"Vazquez-Davila, M.",
"Bidan, C. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721109v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Bacteria attach to surfaces, gather in colonies and get embedded in a self-produced polymeric matrix to form biofilms. 1 , 2 This prevalent bacterial form of life is sessile, cooperative and enhances resist... |
biorxiv | 10.64898/2026.04.27.721100 | 10.64898/2026.04.27.721100 | 2 | Murine osteosarcoma recapitulates the driver landscape and genomic complexity of osteosarcoma evolution in humans | [
"Smith, G. A.",
"van Belzen, I. A. E. M.",
"Epinette, M.",
"Herdes, E.",
"Mercer, K. L.",
"Butterworth, C. G.",
"Rust, A. G.",
"Flanagan, A. M.",
"Jones, M. G.",
"Cortes-Ciriano, I.",
"Jacks, T."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721100v2 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Osteosarcoma (OS) is the most common primary bone cancer and primarily affects adolescents and young adults. 1 Treatment has not changed significantly in over 40 years. Though current treatment is effective... |
biorxiv | 10.64898/2026.04.27.721080 | 10.64898/2026.04.27.721080 | 1 | Connecting polygenic disease risk to cell states and regulatory programs through single-cell chromatin accessibility | [
"Yu, L.",
"Deary, L. T.",
"Liu, Q.",
"Zhang, Q.",
"Zhao, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721080v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Identifying the tissues and cell types that contribute to a disease is a crucial step toward understanding disease mechanisms. Many complex diseases exhibit substantial heritability, indicating that genetic... |
biorxiv | 10.64898/2026.04.27.721047 | 10.64898/2026.04.27.721047 | 1 | PqqU (PA2289) is responsible for Pyrroloquinoline Quinone Uptake in Pseudomonas aeruginosa | [
"Paschalidis, C.",
"Ferry, M.",
"Revillot-Schmidt, A.-E.",
"Hoegy, F.",
"Mislin, G. L. A.",
"Chicher, J.",
"Schalk, I. J.",
"Cunrath, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721047v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Pseudomonas aeruginosa , a ubiquitous Gram-negative bacterium, is renowned for its metabolic versatility and opportunistic pathogenicity. Its ability to thrive in diverse environments is underpinned by a hi... |
biorxiv | 10.64898/2026.04.27.720995 | 10.64898/2026.04.27.720995 | 1 | Genome-wide association study of morphometric and metabolic characteristics in the European populations of the sugar kelp Saccharina latissima | [
"MAUGER, S.",
"AVIA, K.",
"JAUGEON, L.",
"RUGGERI, P.",
"NEHR, Z.",
"SALIA, O. I.",
"COUDRET, J.",
"GOUHIER, E.",
"BAUD, A.",
"LOISEL, S.",
"FORT, A.",
"SULPICE, R.",
"DESTOMBE, C.",
"POTIN, P.",
"COCK, J. M.",
"VALERO, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.720995v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The sugar kelp Saccharina latissima (Linnaeus) ( Lane et al., 2006 ) is an ecologically and economically important species. It is a sister species of the Asian Saccharina japonica (J.E. Areschoug) ( Lane et... |
biorxiv | 10.64898/2026.04.26.720961 | 10.64898/2026.04.26.720961 | 2 | Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens | [
"Chen, Z.",
"Chen, W.",
"Lee, Y. S.",
"Jones, W.",
"Goetzl, L.",
"Thomas, J. D.",
"Dong, Y.",
"Wang, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720961v2 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cannabis is one of the most commonly used substances in pregnant women 1 , 2 . A recent study reported a prevalence as high as 22.4% for detectable prenatal marijuana exposure based on umbilical cord blood ... |
biorxiv | 10.64898/2026.04.26.720791 | 10.64898/2026.04.26.720791 | 2 | Eutherian NLRP3 is distinguished by conserved regulatory features absent in non-eutherian NLRP3-like proteins | [
"Williams, D. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720791v2 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Inflammasomes are immune signalling complexes that trigger a protective inflammatory response upon detection of damage associated molecular patterns (DAMPs) or pathogen associated molecular patterns (PAMPs)... |
biorxiv | 10.64898/2026.04.25.720804 | 10.64898/2026.04.25.720804 | 1 | Structural basis of dynein interaction with diverse activating adaptors | [
"d'Amico, E. A.",
"Chaaban, S.",
"Abid Ali, F.",
"Michalski, L.",
"Carter, A. P."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720804v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Cytoplasmic dynein-1 (dynein) is the main minus-end directed microtubule motor in human cells. It has a critical role in transporting and maintaining the spatial organisation of a broad range of cargoes, in... |
biorxiv | 10.64898/2026.04.25.719469 | 10.64898/2026.04.25.719469 | 1 | Kilobase-scale compartments enabled by CRUSH reveal regulatory programs across cell types, single-cells, and ancient mammoths | [
"Kalluchi, A.",
"Nolan, B.",
"Reznicek, T. E.",
"Harris, H. L.",
"Udupa, D.",
"Cummings, C. T.",
"Rowley, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.719469v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main Text"
},
{
"type": "para",
"text": "The three-dimensional organization of the genome plays a fundamental role in gene regulation, with chromatin partitioned into active (A) and inactive (B) compartments that reflect distinct nuclear environments... |
biorxiv | 10.64898/2026.04.24.720765 | 10.64898/2026.04.24.720765 | 1 | Tuning the brain at 40 Hz: Synergistic effects of combined tACS and auditory steady-state response | [
"Masina, F.",
"Pezzetta, R.",
"Genero, N.",
"Tonin, A.",
"Arcara, G.",
"Mapelli, D."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720765v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Brain gamma oscillations range approximately from 30 to 100 Hz and are thought to arise from the interplay between inhibitory gamma-aminobutyric acid (GABA)ergic interneurons and excitatory inputs from pyra... |
biorxiv | 10.64898/2026.04.24.720763 | 10.64898/2026.04.24.720763 | 1 | Adjuvants MPLA and SMNP induce antiviral immunity and indirectly revert HIV-1 latency | [
"Jansen, J.",
"Vlaming, K. E.",
"Helgers, L. C.",
"Schumacher, E.",
"Kaptein, T. M.",
"Sanders, R. W.",
"de Bree, G. J.",
"Geijtenbeek, T. B. H.",
"Kootstra, N. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720763v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Adjuvants are important in vaccine strategies to induce innate immunity and thereby elicit strong adaptive immunity. Prophylactic and therapeutic HIV-1 vaccination strategies have been developed to prevent ... |
biorxiv | 10.64898/2026.04.24.720739 | 10.64898/2026.04.24.720739 | 1 | Reverse gingival venipuncture: a refined technique for serial blood collection in small rodents | [
"Luapan, J.",
"Johnson, H.",
"Seiberlich, M.",
"Brayton, C. A.",
"Jimenez, I. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720739v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Venipuncture is an essential technique for collecting blood samples for diagnostic and research purposes. Small rodents such as mice, rats, hamsters, chinchillas, and guinea pigs have grown significantly in... |
biorxiv | 10.64898/2026.04.24.720735 | 10.64898/2026.04.24.720735 | 1 | Chromosome 2q31.2 Deletion Impairs Neuronal Plasticity through Integrated Stress Response Activation | [
"Nakamura, B. N.",
"Sedighi, S.",
"Das, D.",
"Joshi, R. M.",
"Neman, J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720735v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Rare genomic disorders offer a powerful framework for uncovering the molecular mechanisms that govern human brain development and function. Structural chromosomal variants, including microdeletions, can dis... |
biorxiv | 10.64898/2026.04.24.720732 | 10.64898/2026.04.24.720732 | 1 | Topological attention asymmetry in ESM-2 attention implicitly encodes the allosteric hierarchy of the adenosine A2A receptor | [
"Moya-Garcia, A. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720732v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "heading",
"level": 2,
"text": "Allostery as an information channel"
},
{
"type": "para",
"text": "Allostery is the capacity of a biological macromolecule to couple the state of one site to the function of a... |
biorxiv | 10.64898/2026.04.24.720718 | 10.64898/2026.04.24.720718 | 1 | Age-related morphological changes in the C57BL/6J mouse calvaria: implications for stereotaxic neurosurgery | [
"Knight, Z. A.",
"Jang, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720718v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "The mouse calvaria serves as the coordinate reference system for stereotaxic neurosurgery. Targeting of brain structures depends on the positional stability of two cranial landmarks, bregma and lambda, and ... |
biorxiv | 10.64898/2026.04.24.720670 | 10.64898/2026.04.24.720670 | 1 | Structure of a Stand-Alone Homodimeric NRPS Condensation Domain Reveals Occlusion of the Canonical Carrier-Protein Interface | [
"Singh, J.",
"Grant, T. D.",
"Gulick, A. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720670v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Nonribosomal peptide synthetases (NRPSs) are modular enzymatic assembly lines that catalyze the biosynthesis of a wide range of peptide and peptide-like natural products, many of which possess important bio... |
biorxiv | 10.64898/2026.04.24.720667 | 10.64898/2026.04.24.720667 | 1 | Mechanisms of USP7/MAGEL2 Complex Assembly and Its Mutational Disruption in Neurodevelopmental Diseases | [
"Korchak, E. J.",
"Soriano, G.",
"Semenova, I.",
"Hao, B.",
"Stepihar, D.",
"Bayat, T.",
"Fon Tacer, K.",
"Bezsonova, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720667v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Ubiquitination is a reversible post-translational modification that regulates protein degradation, signal transduction, gene expression, and DNA repair. The ubiquitin-mediated signaling is essential for the... |
biorxiv | 10.64898/2026.04.24.720666 | 10.64898/2026.04.24.720666 | 1 | Root system architecture responses to high-temperature stress in synthetic-derived wheat lines reveal distinct adaptive patterns | [
"Islam, S. M. M.",
"Tahir, I. S. A.",
"Akashi, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720666v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Wheat ( Triticum aestivum L.) is the most widely cultivated cereal crop worldwide and provides a major source of calories for more than 35% of the global population [ 1 ] . With the global population projec... |
biorxiv | 10.64898/2026.04.24.720662 | 10.64898/2026.04.24.720662 | 1 | The FERONIA receptor kinase is required for high humidity responses in Arabidopsis | [
"Opachaloemphan, C.",
"Hilleary, R.",
"Wu, N.",
"Kuan, C.",
"Nomura, K.",
"He, S. Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720662v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "To survive, plants rely on adaptive responses enabling their survival and resilience in dynamic environments 1 , 2 . Among these environmental variables, air humidity exerts a strong influence on plant biol... |
biorxiv | 10.64898/2026.04.24.720639 | 10.64898/2026.04.24.720639 | 1 | Tipping points are typical in ecosystems with higher-order interactions | [
"Lechon-Alonso, P.",
"Miller, Z. R.",
"Liaghat, A.",
"Breiding, P.",
"Pascual, M.",
"Allesina, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720639v1 | 2026-04-28T00:00:00 | [
{
"type": "para",
"text": "Ecosystems worldwide face environmental changes that will push communities of species beyond the conditions supporting present-day coexistence. Understanding when and how coexistence will be lost are central questions for both ecological theory and conservation [ 1 ]. Structural-s... |
biorxiv | 10.64898/2026.04.24.720638 | 10.64898/2026.04.24.720638 | 1 | Rewiring Oncogenic Transcriptional Complexes with Domain-ALTeration Chimeras (DALTACs) in Prostate Cancer | [
"Luo, J.",
"Yang, J.",
"Tien, J. C.-Y.",
"Wang, M.",
"Das, S.",
"Xiang, W.",
"Young, E.",
"Tosovic, J.",
"Mannan, R.",
"Cai, J.",
"Liu, Y.",
"Gu, K.",
"Mahapatra, S.",
"Li, S.",
"Yin, Y.",
"Eyunni, S.",
"Todd, A. J.",
"Jin, S.",
"Cao, X.",
"Miner, S. J.",
"Sudharshan, R.",
... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720638v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Aberrant transcriptional programs are a hallmark of cancer, driving malignant transformation, particularly in ehancer-driven cancers such as metastatic castration-resistant prostate cancer (mCRPC) 1 , 2 . T... |
biorxiv | 10.64898/2026.04.24.720627 | 10.64898/2026.04.24.720627 | 1 | Thermal niche tracking in thirteen British temperate passerines | [
"Lonero, I.",
"Eddowes, M. J.",
"Burgess, M. D.",
"Pearce-Higgins, J. W.",
"Phillimore, A. B."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720627v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "One way climate change can impact on biodiversity is through a direct effect on the availability of favourable thermal conditions ( Bellard et al., 2012 ; Pörtner & Farrell, 2008 ). A thermal niche defines ... |
biorxiv | 10.64898/2026.04.24.720607 | 10.64898/2026.04.24.720607 | 1 | Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana | [
"Sanchez Lopez, J. F.",
"Stefkova, M.",
"Yang, F.",
"Pecinka, A.",
"Robert, H. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720607v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "In recent decades, average global temperatures have increased due to climate change, negatively affecting ecosystems and causing losses amounting to millions of dollars in decreased food and feed production... |
biorxiv | 10.64898/2026.04.24.720604 | 10.64898/2026.04.24.720604 | 2 | OPM-FLUX: A Pipeline for OPM MEG Data Analysis | [
"Rakshit, A.",
"Ghafari, T.",
"Kowalczyk, A. U.",
"Jensen, O."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720604v2 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Optically pumped magnetometer-based magnetoencephalography (OPM-MEG) has recently emerged as a powerful brain imaging modality in cognitive neuroscience, as demonstrated across multiple OPM-MEG studies ( Bo... |
biorxiv | 10.64898/2026.04.24.720584 | 10.64898/2026.04.24.720584 | 1 | Dibenzoylmethane, a novel β-diketone pore blocker of large-conductance calcium-activated potassium channel | [
"Koprowski, P.",
"Miszta, P.",
"Strawa, J. W.",
"Krempovych, Y.",
"Ziajowska, A.",
"Filipek, S.",
"Szewczyk, A.",
"Tomczyk, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720584v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Large-conductance calcium- and voltage-activated potassium (BK Ca , K Ca 1.1) channels couple membrane depolarization to intracellular Ca 2+ signals and provide powerful negative feedback control of excitab... |
biorxiv | 10.64898/2026.04.24.720565 | 10.64898/2026.04.24.720565 | 1 | When More Is Not Better: Increased Motor Cortex Recruitment In Older Adults Is Associated With Performance Decline During High-Demand Cognitive-Motor Tasks | [
"Keime, M.",
"Ranglani, S.",
"Harvey, M.",
"Sampaio-Baptista, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720565v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Ageing is accompanied by structural ( Fujiyama et al., 2016 ), functional ( Wu et al., 2007 ) and metabolic ( Seidler et al., 2010 ) changes in the brain, which collectively lead to widespread reorganisatio... |
biorxiv | 10.64898/2026.04.24.720555 | 10.64898/2026.04.24.720555 | 1 | Giving you five: A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology | [
"Brammerloh, M.",
"Alkemade, A.",
"Bazin, P.-L.",
"Jantzen, C.",
"Jäger, C.",
"Herrler, A.",
"Pine, K. J.",
"Morawski, M.",
"Balesar, R.",
"Amunts, K.",
"Forstmann, B. U.",
"Weiskopf, N.",
"Kirilina, E."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720555v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background & Summary"
},
{
"type": "para",
"text": "The kidney-bean-sized substantia nigra (SN) is a nucleus in the midbrain, situated between the medio-rostral nucleus ruber (NR), and the ventro-lateral crus cerebri 1 , 2 , with a wide-ranging impac... |
biorxiv | 10.64898/2026.04.24.720543 | 10.64898/2026.04.24.720543 | 1 | The Value of Multi-Year Sampling for Detecting Fine-Scale Population Genetic Structure in Marine Fishes: A Case Study of Juvenile Southern Flounder | [
"Harned, S.",
"Mankiewicz, J.",
"Borski, R.",
"Godwin, J.",
"Burford Reiskind, M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720543v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "The assessment of genetic structure and population connectivity is fundamental for understanding recruitment dynamics in marine species ( Cowen et al., 2007 ; Tova Verba et al., 2023 ). However, high disper... |
biorxiv | 10.64898/2026.04.24.720536 | 10.64898/2026.04.24.720536 | 1 | Accurate ab initio gene prediction in eukaryotes with Tiberius in multiple clades | [
"Gabriel, L.",
"Bruna, T.",
"Kaur, A.",
"Krishnan, A.",
"Ortmann, F.",
"Salamov, A.",
"Talbot, S.",
"Becker, F.",
"Krieg, R.",
"Wheat, C. W.",
"Grigoriev, I. V.",
"Stanke, M.",
"Hoff, K. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720536v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Accurate identification of protein-coding genes is a critical step in genome annotation, yet fewer than 20% of the currently available genomes at NCBI Datasets [ O’Leary et al., 2024 ] have associated gene ... |
biorxiv | 10.64898/2026.04.24.720531 | 10.64898/2026.04.24.720531 | 1 | Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer | [
"Duan, N.",
"Hua, Y.",
"Zhou, Z.",
"Jin, N.",
"Li, W.",
"Yin, Y."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720531v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Breast cancer is currently the most prevalent malignancy affecting women worldwide, with nearly a quarter of all cases being HER2-positive subtypes 1 . Although CDK4/6 inhibitors, tyrosine kinase inhibitors... |
biorxiv | 10.64898/2026.04.24.720525 | 10.64898/2026.04.24.720525 | 1 | Multiscale structural control of airflow, diffusion and heat transfer in non-fungus farming termite mounds | [
"Karibi-Botoye, N. F.",
"Theraulaz, G.",
"Muljadi, B.",
"Demyanov, V.",
"Singh, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720525v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Termite mounds are complex biogenic structures that have long attracted attention from both scientists and architects due to their remarkable integration of form and function ( 1 ). These structures maintai... |
biorxiv | 10.64898/2026.04.24.720503 | 10.64898/2026.04.24.720503 | 1 | Proteome-aware organ proxy aging clocks | [
"Xu, H.",
"Chen, J.",
"Chen, D.",
"Mao, K.",
"HAN, J.-D. J."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720503v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Accurately quantifying the biological aging process is highly dependent on reliable aging clocks. However, identifying clinically valuable aging biomarkers and constructing universally applicable aging cloc... |
biorxiv | 10.64898/2026.04.24.720455 | 10.64898/2026.04.24.720455 | 1 | The selective OX1R antagonist 1-SORA-51 reduces binge-like feeding behavior in male and female mice without detectable changes in dopamine. | [
"DiLeone, R.",
"Trinko, J. R.",
"Atangana, E.",
"Diaz, D.",
"Ashkenazi, A.",
"Foscue, E. P.",
"Kong, E. M."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720455v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Binge eating disorder (BED) is defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) as an eating disorder that combines aspects of overeating with negative psychological or social ef... |
biorxiv | 10.64898/2026.04.24.720317 | 10.64898/2026.04.24.720317 | 1 | Hepatocellular Carcinoma Revisited from Single Cell Sequencing: Dynamic Evolution from Epithelial Dedifferentiation to Mesenchymal Remodeling | [
"Yan, K.",
"Dong, W.",
"Wu, Y.",
"Han, Z.",
"Hong, J.",
"Ma, H.",
"Zhu, C.",
"Xiong, Y.",
"Yang, Z."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720317v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Single-cell RNA sequencing has revealed pervasive heterogeneity in hepatocellular carcinoma (HCC), consistently highlighting tumor cell plasticity, T-cell exhaustion, and large-scale remodeling of the immun... |
biorxiv | 10.64898/2026.04.24.720222 | 10.64898/2026.04.24.720222 | 1 | PSEN1 mutant marmoset fibroblasts mimic multi-omic signatures of Alzheimer's disease | [
"Kumar, S.",
"Haber, A.",
"Spruce, C.",
"Duong, D.",
"Seyfried, N.",
"Bailey, L.",
"Choi, S.-H.",
"Hachem, S.",
"Mou, Y.",
"Ha, S.-K.",
"Park, J. E.",
"Homanics, G. E.",
"Sukoff Rizzo, S. J.",
"Silva, A. C.",
"Carter, G. W."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720222v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION/BACKGROUND"
},
{
"type": "para",
"text": "The proliferation of genetic and multi-omic studies of Alzheimer’s disease and related dementias (ADRD) has generated abundant molecular hypotheses of disease origins and progression. While analo... |
biorxiv | 10.64898/2026.04.24.718944 | 10.64898/2026.04.24.718944 | 1 | The aging modulator miR-29 is essential for adult cardiomyocyte function | [
"Roiz-Valle, D.",
"Folgueira, C.",
"Moledo-Nodar, L.",
"Tartiere, A. G.",
"Cicuendez, B.",
"Romero-Becerra, R.",
"Rodriguez, F.",
"He, Y.-W.",
"Freije, J. M. P.",
"Sabio, G.",
"Lopez-Otin, C.",
"Caravia, X. M.",
"P. Ugalde, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.718944v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Aging is the strongest risk factor for cardiovascular diseases (CVDs) ( 1 ). As the population ages, understanding the molecular pathways that preserve cardiac homeostasis becomes increasingly important. Ca... |
biorxiv | 10.64898/2026.04.24.718784 | 10.64898/2026.04.24.718784 | 1 | CRISPR activation of PIKFYVE as potential therapy for FIG4 deficiency | [
"Doctrove, Q.",
"Lenk, G. M.",
"Lipuma, V. H.",
"Meisler, M. H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.718784v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Charcot Marie Tooth type 4J (CMT4J) is a rare neurological disorder characterized by motor disfunction, bone deformities, and/or cognitive impairment ( Chow et al., 2007 ; Boura et al., 2024 ; Sadjadi et al... |
biorxiv | 10.64898/2026.04.23.720248 | 10.64898/2026.04.23.720248 | 1 | Local ancestry inference identifies robust evidence of selection in Neolithic Europe | [
"Mies, G.",
"Mathieson, I."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.23.720248v1 | 2026-04-28T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Early farmers from the Anatolian peninsula initiated the European agricultural transition (Neolithic; 10-7 thousand years ago) by introducing domesticated animals, agricultural subsistence, and related life... |
biorxiv | 10.64898/2026.03.11.710688 | 10.64898/2026.03.11.710688 | 2 | Learning to Attend Through Value-Based Hypothesis Testing | [
"Maher, C.",
"Saez, I.",
"Radulescu, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.03.11.710688v2 | 2026-03-12T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Natural environments are high-dimensional and noisy, requiring individuals to determine which features are relevant for learning and choice. Selective attention plays a key role in this process by guiding w... |
biorxiv | 10.1101/2025.08.17.670735 | 10.1101/2025.08.17.670735 | 2 | TissueFormer: Extending single-cell foundation models to predict population-level phenotypes | [
"Benjamin, A. S.",
"Zador, A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2025.08.17.670735v2 | 2025-08-19T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Background"
},
{
"type": "para",
"text": "Many important features such as tissue identity, disease state, or treatment response are defined at the level of cell populations but are driven by patterns of single-cell phenotypes. Observations of populat... |
biorxiv | 10.1101/2024.11.07.622409 | 10.1101/2024.11.07.622409 | 6 | Using a sequential sampling algorithm to apply the niche-neutral model to species occurrence patterns | [
"Kristensen, N. P.",
"Sin, Y. C. K.",
"Lim, H. S.",
"Rheindt, F. E.",
"Chisholm, R. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.1101/2024.11.07.622409v6 | 2024-11-08T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "What determines the pattern of species occurrence across patches in a landscape? One method for identifying patterns of potential ecological interest is null-model analysis using randomised data ( Gotelli, ... |
biorxiv | 10.64898/2026.04.27.721111 | 10.64898/2026.04.27.721111 | 1 | Macrophage-Derived PDGF-BB and GDF-15 Promote Drug Resistance in KRAS-Mutant Colorectal Cancer | [
"Aston, B. S.",
"Badmos, H. A.",
"Cagan, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721111v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Colorectal cancer (CRC) is the second leading cause of cancer deaths globally [ 1 ]. Approximately 45% of patients have an activating KRAS mutation (K-CRC), commonly in codon 12 or 13, that results in oncog... |
biorxiv | 10.64898/2026.04.27.721098 | 10.64898/2026.04.27.721098 | 1 | Unraveling protein conformational plasticity with PROTEUS | [
"Caparelli Piochi, L. F.",
"Karami, Y.",
"Khakzad, H."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721098v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Proteins are not static objects but dynamic ensembles that sample alternative conformations across timescales ranging from picoseconds to seconds. This conformational plasticity underlies diverse biological... |
biorxiv | 10.64898/2026.04.27.721040 | 10.64898/2026.04.27.721040 | 1 | Inhibiting the interaction between the mitochondrial receptor Tom70 and SARS CoV 2 Orf9b with small molecules | [
"San Felipe, C.",
"Verba, K. A.",
"Krogan, N. J.",
"Grabe, M.",
"Fraser, J. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.721040v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "During viral infection, one of the necessary steps to successful replication is the suppression and evasion of the host’s immune system ( Stetson and Medzhitov 2006 ; Takeuchi and Akira 2009 ). The virus SA... |
biorxiv | 10.64898/2026.04.27.720408 | 10.64898/2026.04.27.720408 | 1 | Generative design of sequence specific DNA binding proteins | [
"Sehgal, E.",
"Politanska, Y.",
"Mitra, R.",
"Kim, P. T.",
"Gonzalez Rodriguez, N.",
"Warrier, T.",
"Kubaney, A.",
"Morishita, A.",
"Quijano, R.",
"Butcher, J.",
"Krishna, R.",
"Pecoraro, R.",
"Belmont, B.",
"Roullier, N.",
"Goreshnik, I.",
"Vafeados, D. K.",
"Kwon, P.",
"Ramarao, ... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.27.720408v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Main"
},
{
"type": "para",
"text": "DNA binding proteins interpret and regulate the genome across all domains of life, enabling processes ranging from transcriptional control to genome maintenance 1 . The ability to design proteins that recognize arb... |
biorxiv | 10.64898/2026.04.26.720927 | 10.64898/2026.04.26.720927 | 1 | Triplex formation drives noncontiguous VIPR RNA-guided DNA recognition | [
"Yoon, P. H.",
"Docter, T. A.",
"Zhang, Z.",
"Loi, K. J.",
"Valentin-Alvarado, L. E.",
"Brohawn, S. G.",
"Doudna, J. A."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720927v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "RNA-guided systems solve nucleic acid recognition by coupling programmable base pairing to protein scaffolds. In every characterized instance, contiguous base pairing between the guide RNA and substrate dic... |
biorxiv | 10.64898/2026.04.26.720818 | 10.64898/2026.04.26.720818 | 1 | Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming | [
"Keshri, R.",
"Foreman, Z.",
"Barrett, P.",
"Robinson, A. J.",
"Reyes, G.",
"Phal, A. A.",
"Krishnakumar, A.",
"Narog, E.",
"Chiu, M.",
"Jain, S.",
"Wang, X.",
"Lee, D.",
"Exposit, M.",
"Abedi, M.",
"Smith, A. S. T.",
"Srivatsan, S. R.",
"Shendure, J.",
"Mathieu, J.",
"Mack, D. L... | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720818v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Skeletal muscle strength and function begin to decline as early as the third decade of life, initiating a progressive trajectory toward sarcopenia, a major and growing health burden in the aging population ... |
biorxiv | 10.64898/2026.04.26.720784 | 10.64898/2026.04.26.720784 | 1 | Mechanism of nucleolytic degradation of human ribosomes | [
"Diehl, F. F.",
"Buskirk, A. R.",
"Green, R."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720784v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Ribosome levels are finely tuned to meet cellular protein synthesis demands. Ribosome biogenesis is suppressed during stress, and although mature ribosomes are stable in normal conditions, stress-induced ri... |
biorxiv | 10.64898/2026.04.26.720559 | 10.64898/2026.04.26.720559 | 1 | Molecular mechanism of M1-mediated influenza A virus assembly | [
"Guo, H.",
"Ibiricu, I.",
"Riggi, M.",
"Mohr, R.",
"Villa, R.",
"Schaefer, T.",
"Liu, Z.",
"Boicu, M.",
"Briggs, J. A. G."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.26.720559v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Influenza A virus (IAV) drives annual seasonal epidemics and poses an ongoing pandemic threat. The virion is pleiomorphic – often filamentous when isolated from infected hosts, but commonly bacilliform afte... |
biorxiv | 10.64898/2026.04.25.720767 | 10.64898/2026.04.25.720767 | 1 | Genomic Diversity, Host Associations, and Tissue Tropism of Hydrangea Ringspot Virus: A Global and Regional Perspective | [
"Osorio-Marulanda, J.",
"Lopez-Jimenez, J.",
"Alzate, J. F."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.25.720767v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "INTRODUCTION"
},
{
"type": "para",
"text": "Herbaceous ornamental plants are valued for their aesthetic qualities and represent an important component of the global horticultural industry. They are used for both decorative and practical uses througho... |
biorxiv | 10.64898/2026.04.24.720727 | 10.64898/2026.04.24.720727 | 1 | TFAM organizes DNA into compact higher order structures | [
"Weerawarana, S. R.",
"Tian, W.",
"Luger, K."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720727v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Human mitochondria contain a 16.5 kb circular genome that encodes 13 essential protein subunits of the electron transport chain, along with several essential RNAs 1 . Mutations or damage to mitochondrial DN... |
biorxiv | 10.64898/2026.04.24.720652 | 10.64898/2026.04.24.720652 | 1 | Antarctic fish cell cultures show adaptation of organelle morphology and dynamics to extreme cold | [
"van Tartwijk, F. W.",
"Marty, A.-P. M.",
"Rahmani, A.",
"Jia, Y.",
"Ward, E. N.",
"Hussain, I.",
"Peck, L. S.",
"Kaminski, C. F.",
"Clark, M. S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720652v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Temperature affects the behaviour of living systems, influencing key cellular processes such as enzyme kinetics, membrane fluidity, and macromolecular assembly 1 , 2 . Cold-blooded animals have therefore ev... |
biorxiv | 10.64898/2026.04.24.720612 | 10.64898/2026.04.24.720612 | 1 | Aquarius RNA helicase Protects Pluripotent Stem Cell Identity | [
"Lalonde, M.",
"Marquez-Gomez, E.",
"Lee, C. S. K.",
"Burton, A.",
"Tsirkas, I.",
"Rezende Pabst, F.",
"Werner, M.",
"Sajid, A.",
"Chaves Murriello, A.",
"Karypidou, X.",
"Ettinger, A.",
"Schauer, T.",
"Straub, T.",
"Torres-Padilla, M.-E.",
"Scialdone, A.",
"Hamperl, S."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720612v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Embryonic stem cells (ESCs) display a dynamic epigenome which is linked to its pluripotency features. Differentiation of ESCs relies on transcriptional rewiring and involves reorganization of DNA replicatio... |
biorxiv | 10.64898/2026.04.24.720546 | 10.64898/2026.04.24.720546 | 1 | CD47 Blockade Reprograms the Monocyte-Macrophage Axis to Promote Inflammation Resolution in Atherosclerosis | [
"Kirtay, M.",
"Ispirjan, M.",
"Bonnard, B.",
"Bruggner, A.-L.",
"Boehringer, L.",
"Miessler, M.",
"Frey, N.",
"Leeper, N. J.",
"Jarr, K.-U."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720546v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Atherosclerosis is a lipoprotein-driven chronic inflammatory disease. While lipid-lowering therapies, such as statins and PCSK9 inhibitors 1 , have improved clinical outcomes, residual cardiovascular risk r... |
biorxiv | 10.64898/2026.04.24.720540 | 10.64898/2026.04.24.720540 | 1 | Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis | [
"Russell, D. G.",
"Simwela, N.",
"Johnston, L.",
"Sassetti, C."
] | CC-BY-4.0 | https://www.biorxiv.org/content/10.64898/2026.04.24.720540v1 | 2026-04-27T00:00:00 | [
{
"type": "heading",
"level": 1,
"text": "Introduction"
},
{
"type": "para",
"text": "Macrophages are highly plastic immune cells that eliminate pathogens through potent antimicrobial mechanisms while balancing their own survival and maintaining tissue homeostasis. In the context of Mycobact... |
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