id stringlengths 6 42 | title stringlengths 3 499 | abstract stringlengths 0 6.24k | label listlengths 0 6 |
|---|---|---|---|
10.1136/jmedgenet-2013-102038 | A type i interferon signature identifies bilateral striatal necrosis due to mutations in ADAR1 | Background: We recently observed mutations in ADAR1 to cause a phenotype of bilateral striatal necrosis (BSN) in a child with the type I interferonopathy Aicardi-Goutières syndrome (AGS). We therefore decided to screen patients with apparently non-syndromic BSN for ADAR1 mutations, and for an upregulation of interferon... | [
"Immunity, Infection and Immunotherapy",
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.3389/fnbot.2018.00023 | Fetal origin of sensorimotor behavior | The aim of this article is to track the fetal origin of infants’ sensorimotor behavior. We consider development as the self-organizing emergence of complex forms from spontaneously generated activity, governed by the innate capacity to detect and memorize the consequences of spontaneous activity (contingencies), and co... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Neuroscience and Disorders of the Nervous System"
] |
AU 2023/050668 W | ENGINEERED HUMAN CARDIAC TISSUE | The present application relates to methods for the generation of engineered human pluripotent stem cell-derived cardiac tissue, engineered cardiac tissue produced by such methods and methods for their use. | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1038/nrmicro2939 | Microbial life under extreme energy limitation | A great number of the bacteria and archaea on Earth are found in subsurface environments in a physiological state that is poorly represented or explained by laboratory cultures. Microbial cells in these very stable and oligotrophic settings catabolize 10 4 - to 10 6 -fold more slowly than model organisms in nutrient-ri... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Environmental Biology, Ecology and Evolution"
] |
174424 | Kac-Moody groups and computer assistants in mathematics | This fellowship will enable the experienced Researcher Dr Rieuwert Blok - a currently USA-based European Union national - and Dr Corneliu Hoffman - as Host researcher based at the University of Birmingham - to carry out innovative and mutually beneficial research utilising their complementary skill sets. Blok brings ... | [
"Mathematics",
"Computer Science and Informatics"
] |
10.4161/viru.1.4.12364 | The relevance of heat shock regulation in fungal pathogens of humans | Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essentia... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Immunity, Infection and Immunotherapy"
] |
10.1007/978-3-642-22935-0_43 | Dense Locally Testable Codes Cannot Have Constant Rate And Distance | A q-query locally testable code (LTC) is an error correcting code that can be tested by a randomized algorithm that reads at most q symbols from the given word. An important question is whether there exist LTCs that have the c3 property: constant rate, constant relative distance, and that can be tested with a constant ... | [
"Mathematics",
"Computer Science and Informatics"
] |
979057 | Biopolymers for the generation of 3d tissue engineering scaffolds by solution mask liquid lithography | Three-dimensional (3D) printing in biomedical science has recently advanced the development of tailor-made implants. Designing structural and functional 3D constructs mimetic of both tissues and organs offers a genuine route to personalised implants, improving the patients' quality of life and reducing healthcare costs... | [
"Materials Engineering",
"Biotechnology and Biosystems Engineering",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Synthetic Chemistry and Materials"
] |
714429 | Multicomponent Aerogels with Tailored Nano-, Micro- Macrostructure | Aerogels and hydrogels from nanocrystal building blocks are a fascinating novel class of materials with extremely low densities and large specific surfaces, which partially exhibit the advantageous properties of their nanoscopic building blocks (e.g. size quantized fluorescence or catalytic activity). In the present pr... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics",
"Materials Engineering"
] |
10.1038/emboj.2011.245 | Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture | Vaccinia virus (VACV), the model poxvirus, produces two types of infectious particles: mature virions (MVs) and extracellular virions (EVs). EV particles possess two membranes and therefore require an unusual cellular entry mechanism. By a combination of fluorescence and electron microscopy as well as flow cytometry, w... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.3847/2041-8205/826/1/L1 | Lost And Found Evidence Of Second Generation Stars Along The Asymptotic Giant Branch Of The Globular Cluster Ngc 6752 | We derived chemical abundances for C, N, O, Na, Mg and Al in 20 asymptotic giant branch (AGB) stars in the globular cluster NGC 6752. All these elements (but Mg) show intrinsic star-to-star variations and statistically significant correlations or anticorrelations analogous to those commonly observed in red giant stars ... | [
"Universe Sciences"
] |
10.1371/journal.pgen.1004674 | The Kinesin AtPSS1 Promotes Synapsis and is Required for Proper Crossover Distribution in Meiosis | Meiotic crossovers (COs) shape genetic diversity by mixing homologous chromosomes at each generation. CO distribution is a highly regulated process. CO assurance forces the occurrence of at least one obligatory CO per chromosome pair, CO homeostasis smoothes out the number of COs when faced with variation in precursor ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1088/1742-6596/509/1/012048 | Heavy Flavor Suppression Boltzmann Vs Langevin | The propagation of heavy flavor through the quark gluon plasma has been treated commonly within the framework of Langevin dynamics, i. e. assuming the heavy flavor momentum transfer is much smaller than the light one. On the other hand a similar suppression factor $R_{AA}$ has been observed experimentally for light an... | [
"Fundamental Constituents of Matter"
] |
10.3762/bjnano.5.72 | Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone | Calcium carbonate is the material that builds up the spicules of the calcareous sponges. Recent results revealed that the calcium carbonate/biocalcite-based spicular skeleton of these animals is formed through an enzymatic mechanism, such as the skeleton of the siliceous sponges, evolutionarily the oldest animals that ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Materials Engineering"
] |
311704 | The role of CpG island RNAs and Polycomb-RNA interactions in developmental gene regulation | A great challenge in developmental biology research has been to understand how cell type specific expression programs are orchestrated through regulated access to chromatin. The interaction between non-coding RNAs and chromatin regulators is emerging as an exciting new research area with the potential to explain how ch... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Integrative Biology: from Genes and Genomes to Systems"
] |
EP 2014002723 W | NEW USE FOR JNK INHIBITOR MOLECULES FOR TREATMENT OF VARIOUS DISEASES | The present invention relates to the use of novel JNK inhibitor molecules and their use in a method of treatment of the human or animal body by therapy. | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1111/arcm.12274 | Lead Isotope Analyses Revealed the Key Role of Chang'an in the Mirror Production and Distribution Network During the Han Dynasty | Chang'an (now Xi'an) was the capital of the Western Han Dynasty and the starting point of the Silk Road. In the light of the importance of Chang'an as the centre of politics, economy and cultural interaction, the overarching question proposed in this paper is focused on its role in the mirror production and distributio... | [
"The Study of the Human Past",
"Physical and Analytical Chemical Sciences"
] |
10.1186/s12915-019-0656-2 | Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly | Background: At the beginning of mitosis, the cell forms a spindle made of microtubules and associated proteins to segregate chromosomes. An important part of spindle architecture is a set of antiparallel microtubule bundles connecting the spindle poles. A key question is how microtubules extending at arbitrary angles f... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W3005313438 | Refining early stage interventional composite catheter design | Abstract The development paths of interventional medical devices are long and involve a significant numbers of iterative design steps. Composite interventional catheters deliver implants, facilitate the deployment of delicate therapeutic instruments, measure pressures and temperatures and can remove clots and foreign b... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.1016/j.carbon.2020.01.115 | Influence of diamond crystal orientation on the interaction with biological matter | Diamond has been a popular material for a variety of biological applications due to its favorable chemical, optical, mechanical and biocompatible properties. While the lattice orientation of crystalline material is known to alter the interaction between solids and biological materials, the effect of diamond's crystal o... | [
"Condensed Matter Physics",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Materials Engineering"
] |
10.1088/2041-8205/785/1/L7 | Patchy Accretion Disks In Ultra Luminous X Ray Sources | The X-ray spectra of the most extreme ultra-luminous X-ray sources - those with L ≥ 10^(40) erg s^(-1) remain something of a mystery. Spectral roll-over in the 5-10 keV band was originally detected in in the deepest XMM-Newton observations of the brightest sources; this is confirmed in subsequent NuSTAR spectra. This e... | [
"Universe Sciences",
"Fundamental Constituents of Matter"
] |
interreg_799 | Cultural (garden) heritage as focal points for sustainable tourism | CultTour aims at implementing strategies to preserve/valorise cultural garden and open space heritage sites by giving it a modern use in tourism, conserving the "genius loci" of the site. The need for professional tourism offer and well-educated staff according to international standards is constantly growing in SEE. T... | [
"Human Mobility, Environment, and Space",
"Studies of Cultures and Arts",
"The Study of the Human Past"
] |
640638 | Making Scientific Inferences More Objective | What makes scientific inferences trustworthy? Why do we think that scientific knowledge is more than the subjective opinion of clever people at universities? When answering these questions, the notion of objectivity plays a crucial role: the label ""objective"" (1) marks an inference as unbiased and trustworthy and (2)... | [
"Texts and Concepts",
"The Human Mind and Its Complexity"
] |
230261 | Islamic Law materialized: Arabic legal documents (8th to 15th century) (ILM) | The project examines edited and unedited Arabic legal documents from a new comparative perspective. Documents, immediate manifestations of legal practice, were instruments to assure subjective rights of persons for whom the copy had been issued. Most studies on early Islamic legal practice however focus on literary sou... | [
"The Study of the Human Past",
"Texts and Concepts"
] |
Q4295420 | Atlantic Network of Innovative Toxicity Alert Systems in Safer Marine Products | Main seafood toxins are emerging toxins, non-regulated marine toxins that have proliferated in the Atlantic Area as a consequence of climate change and which are harmful towards public health. ALERTOX-NET aims to facilitate market delivery of safer seafood products by putting at disposal of affected industries a new to... | [
"Products and Processes Engineering",
"Environmental Biology, Ecology and Evolution",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1103/PhysRevB.87.125406 | Phase-locked magnetoconductance oscillations as a probe of Majorana edge states | We calculate the Andreev conductance of a superconducting ring interrupted by a flux-biased Josephson junction, searching for electrical signatures of circulating edge states. Two-dimensional pair potentials of spin-singlet d-wave and spin-triplet p-wave symmetry support, respectively, (chiral) Dirac modes and (chiral ... | [
"Condensed Matter Physics",
"Fundamental Constituents of Matter"
] |
10.1007/JHEP08(2014)079 | Lhc Signatures Of Warped Space Vectorlike Quarks | We study the LHC signatures of TeV scale vectorlike quarks $b'$, $t'$ and $\chi$ with electromagnetic charges -1/3, 2/3 and 5/3 that appear in many beyond the standard model (BSM) extensions. We consider warped extra-dimensional models and analyze the phenomenology of such vectorlike quarks that are the custodial partn... | [
"Fundamental Constituents of Matter"
] |
10.1088/0004-637X/763/2/129 | Keck Spectroscopy Of 3 Z 7 Faint Lyman Break Galaxies The Importance Of Nebular Emission In Understanding The Specific Star Formation Rate And Stellar Mass Density | The physical properties inferred from the SEDs of z>3 galaxies have been influential in shaping our understanding of early galaxy formation and the role galaxies may play in cosmic reionization. Of particular importance is the stellar mass density at early times which represents the integral of earlier star formation. ... | [
"Universe Sciences",
"Physical and Analytical Chemical Sciences"
] |
W2077552010 | A spatial decision support system for the Portuguese public transportation sector | SIGGESC is a spatial decision support system (SDSS), based on a Geographic Information System (GIS), directed towards the public transportation sector. This SDSS contributes to a paradigm shift at the Portuguese Transportation Authority (IMTT) in terms of the process of registering and granting concessions to the bus c... | [
"Computer Science and Informatics",
"Products and Processes Engineering",
"Human Mobility, Environment, and Space"
] |
10.1137/140975255 | Nonlocal Systems Of Conservation Laws In Several Space Dimensions | We present a Lax--Friedrichs-type algorithm to numerically integrate a class of nonlocal and nonlinear systems of conservation laws in several space dimensions. The convergence of the approximate solutions is proved, also providing the existence of a solution in a slightly more general setting than in other results in ... | [
"Mathematics",
"Computer Science and Informatics"
] |
10.1109/ECC.2014.6862461 | Identification Method For Nonlinear Lfr Block Oriented Models With Multiple Inputs And Outputs | Recently, the nonlinear LFR model has been proposed as a candidate model with high potential, due to its surprising flexibility and parsimony. It is a quite general block-oriented model consisting of a static nonlinearity (SNL) and multiple-input-multiple-output (MIMO) dynamics. It can cope with both nonlinear feedforw... | [
"Systems and Communication Engineering",
"Computer Science and Informatics",
"Mathematics"
] |
10.1038/ncomms5905 | A unified design space of synthetic stripe-forming networks | Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been successfully built and modelled, but largely on a case-by-case basis. Here we go beyond individual networks and explore both computationally and synthetically the de... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Biotechnology and Biosystems Engineering"
] |
10.1007/978-3-319-08575-3_22 | The Nitrogen Cycle | This chapter focuses on the nitrogen (N) cycle, a complex network of mainly microbial transformations in which various nitrogen compounds are interconverted. Both microorganisms and plants absorb N from and excrete N into the environment. First, N assimilation is addressed (22. 1), after which N transformations by micr... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution"
] |
223821 | Deconstruction as critical method in political theory | Deconstruction as Critical Method in Political Theory
‘Deconstruction as Critical Method in Political Theory’ (DECON) explores the critical potential of deconstruction for three important - but contested - concepts in political theory: democracy, sovereignty and universality, and systematises deconstruction as a metho... | [
"Institutions, Governance and Legal Systems",
"Texts and Concepts"
] |
10.1021/nn201132a | Single-step injection of gold nanoparticles through phospholipid membranes | We propose and demonstrate a new method of an all-optical, contactless, one-step injection of single gold nanoparticles through phospholipid membranes. The method is based on the combination of strong optical forces acting on and simultaneous optical heating of a gold nanoparticle exposed to laser light tuned to the pl... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
W1175662894 | Formulating Dynamic Agents’ Operational State via Situation Awareness Assessment | Managing autonomy in a dynamic interactive system that contains a mix of human and software agent intelligence is a challenging task. In such systems, giving an agent a complete control over its autonomy is a risky practice while manually setting the agent’s autonomy level is an inefficient approach. This paper address... | [
"Computer Science and Informatics",
"Systems and Communication Engineering"
] |
W1557535254 | Selective oxidation processes of organic substances in water by means of photocatalytic systems | Selective oxidation of benzyl alcohol into benzaldehyde in anoxic acidic aqueous solution, through a TiO2/Cu(II)/solar UV photocatalytic system, has been investigated both in a laboratory scaled reactor equipped with a high-pressure mercury lamp as well as in a solar pilot plant.
During the laboratory experiments, benz... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials",
"Products and Processes Engineering"
] |
US 2016/0037374 W | CYCLOHEXANECARBOXYLIC ACIDS FOR SELECTIVE TASTE MASKING | The use of cyclohexanecarboxylic acids in a consumable to provide taste specific masking effect is provided. | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
W2019567610 | Modulation of Antimicrobial Host Defense Peptide Gene Expression by Free Fatty Acids | Routine use of antibiotics at subtherapeutic levels in animal feed drives the emergence of antimicrobial resistance. Development of antibiotic-alternative approaches to disease control and prevention for food animals is imperatively needed. Previously, we showed that butyrate, a major species of short-chain fatty acids... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Biotechnology and Biosystems Engineering"
] |
interreg_1840 | INUNDA - Actions pilote de prévention des risques d'inondation dans des zones fortement urbanisées | Floods cause extensive human and material damage so are amongst the greatest natural risks for the EU. There were more than 181 large floods on the continent between 1971 and 2001. Germany, Belgium, France, Italy, Spain, Portugal and several countries in Eastern Europe have suffered from the devastating effects of floo... | [
"Products and Processes Engineering",
"Earth System Science"
] |
224292 | Ligustinus project: new survey techniques for an ancient riparian landscape. | The lacus Ligustinus was the great paleo-estuary of ancient Baetis or current Guadalquivir river (Southern Spain). It is a radically transformed landscape because of the intensive sedimentation and other geomorphological dynamics. The estuary banks were highly populated during the Roman period. Important cities and tow... | [
"The Study of the Human Past",
"Human Mobility, Environment, and Space",
"Earth System Science"
] |
W2473308289 | Reversible Increase of Central Choroidal Thickness During High-Altitude Exposure | This study aimed to quantify the impact of high altitude on choroidal thickness and relate changes of altered choroidal blood flow to clinical parameters and acute mountain sickness (AMS). This work is related to the Tübingen High Altitude Ophthalmology (THAO) study.Enhanced depth imaging spectral-domain optical cohere... | [
"Physiology in Health, Disease and Ageing",
"Earth System Science"
] |
10.1038/s41598-018-32997-9 | Cytometry meets next-generation sequencing – RNA-Seq of sorted subpopulations reveals regional replication and iron-triggered prophage induction in Corynebacterium glutamicum | Phenotypic diversification is key to microbial adaptation. Currently, advanced technological approaches offer insights into cell-to-cell variation of bacterial populations at a spatiotemporal resolution. However, the underlying molecular causes or consequences often remain obscure. In this study, we developed a workflo... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Cell Biology, Development, Stem Cells and Regeneration",
"Biotechnology and Biosystems Engineering"
] |
10.1016/j.cbpa.2014.12.020 | Recent developments in enzyme promiscuity for carbon-carbon bond-forming reactions | Numerous enzymes have been found to catalyze additional and completely different types of reactions relative to the natural activity they evolved for. This phenomenon, called catalytic promiscuity, has proven to be a fruitful guide for the development of novel biocatalysts for organic synthesis purposes. As such, enzym... | [
"Synthetic Chemistry and Materials",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
IB 2021052712 W | AIRCRAFT STRUCTURE AND ASSOCIATED TOOLS AND METHODS | An aircraft including a fuselage with one or more wings extending from the fuselage. The aircraft may include one or more apertures in a surface of at least one of the fuselage and the one or more wings. The one or more apertures may be configured to enable air to pass through the one or more apertures when the aircraf... | [
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
172350 | Establishing a european knowledge and learning mechanism to improve the policy-science-society interface on biodiversity and ecosystem services | The aim of EKLIPSE is to establish an innovative, light, self-sustainable EU support mechanism for evidence-based policy on biodiversity and ecosystems services open to all relevant knowledge holders and users, and to hand over this mechanism to the wider knowledge community by the end of the project. The mechanism wil... | [
"Environmental Biology, Ecology and Evolution",
"Institutions, Governance and Legal Systems",
"The Social World and Its Interactions"
] |
172767 | Cell-Cell interactions at the neurovascular interface | The coordinated orchestration of cell movements is a vital process for assembling functional structures. In recent years we have learned a simplifying lesson: organ development is governed by a limited set of conserved cell-to-cell communication signaling pathways repeatedly used in different contexts. Particularly fas... | [
"Neuroscience and Disorders of the Nervous System",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.5194/acp-10-1885-2010 | Atmospheric data over a solar cycle: No connection between galactic cosmic rays and new particle formation | Aerosol particles affect the Earth's radiative balance by directly scattering and absorbing solar radiation and, indirectly, through their activation into cloud droplets. Both effects are known with considerable uncertainty only, and translate into even bigger uncertainties in future climate predictions. More than a de... | [
"Physical and Analytical Chemical Sciences",
"Earth System Science"
] |
interreg_3461 | SUstainable fiSHeries wIth DROnes data Processing | Within SUSHI-DROP, a customized unmanned underwater vehicles will be developed and equipped with acoustical and optical technologies in order to implement a non-invasive mean to assess environmental status of habitats, fish stocks population and, in general, to monitor the biodiversity of marine ecosystems. We are plan... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution",
"Computer Science and Informatics",
"Products and Processes Engineering"
] |
W2021873779 | Advances in inductive position sensor technology | Purpose The purpose of this paper is to outline the basic principles of inductive position sensors. Design/methodology/approach The paper explains one company's advances in inductive position technology in detail, together with some of the applications for which they are now suitable. Findings It is shown that concentr... | [
"Systems and Communication Engineering",
"Products and Processes Engineering"
] |
W2089527954 | Unfolding of electronic structure through induced representations of space groups: Application to Fe-based superconductors | We revisit the problem that relevant parts of bandstructures for a given cell choice can reflect exact or approximate higher symmetries of subsystems in the cell and can therefore be significantly simplified by an unfolding procedure that recovers the higher symmetry. We show that bandstructure unfolding can be underst... | [
"Condensed Matter Physics",
"Mathematics"
] |
10.1534/g3.114.014845 | Population genetics of Anopheles coluzzii immune pathways and genes | Natural selection is expected to drive adaptive evolution in genes involved in host-pathogen interactions. In this study, we use molecular population genetic analyses to understand how natural selection operates on the immune system of Anopheles coluzzii (formerly A. gambiae "M form"). We analyzed patterns of intraspe... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Environmental Biology, Ecology and Evolution",
"Immunity, Infection and Immunotherapy"
] |
W2587084227 | Strategy with Externalities (Version 1) | The purpose of this model is to explore the effects of technological and social shifts on the behavior of incumbent and startup firms. The model was constructed to provide insight into the choices firms make regarding adoption of new energy technologies. A firm’s performance is determined by its location on an NK fitne... | [
"Computer Science and Informatics",
"Individuals, Markets and Organisations"
] |
215728 | Computational design of novel functional proteins for immunoengineering | Finely orchestrated protein activities are at the heart of the most fundamental cellular processes. The rational and structure-based design of novel functional proteins holds the promise to revolutionize many important aspects in biology, medicine and biotechnology. Computational protein design has led the way on ratio... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Immunity, Infection and Immunotherapy",
"Computer Science and Informatics"
] |
10.1098/rsta.2013.0027 | Performance and optimization of X-ray grating interferometry | The monochromatic and polychromatic performance of a grating interferometer is theoretically analysed. The smallest detectable refraction angle is used as a metric for the efficiency in acquiring a differential phase-contrast image. Analytical formulae for the visibility and the smallest detectable refraction angle are... | [
"Physical and Analytical Chemical Sciences",
"Systems and Communication Engineering"
] |
617777 | COLONISATION AND CULTURAL DIVERSIFICATION IN UNFAMILIAR LANDSCAPES | This project explores the relationship between climate change and human behaviour. During the harshest conditions of the last ice age European human populations abandoned northern latitudes, with their range contracting to southern regions. By the time ice sheets retreated and large areas of land became available for r... | [
"The Study of the Human Past",
"Earth System Science"
] |
950427 | A GLOBAL THEORY OF REFLEXIVE DEBT (DELIBERATION) | Modern capitalism is essentially built on the institution of debt. The unlimited conception of debt reinforces an infinite growth logic and drives economic, political, cultural and ecological unsustainability. A crucial research question is how to constitute debt as more sustainable socio-economic medium. The RESOLVENC... | [
"Institutions, Governance and Legal Systems",
"Individuals, Markets and Organisations"
] |
10.1103/PhysRevB.90.201305 | Excitonic ring formation in ultrapure bulk GaAs | We report on spatially resolved low-temperature photoluminescence (PL) measurements of excitons in ultrapure bulk GaAs. At moderate excitation densities we observe butterfly-shaped luminescence images in the wavelength-radial distance plane with a pronounced quench of the exciton PL intensity at the excitation center. ... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences"
] |
10.1016/j.neuropharm.2015.09.019 | Purinergic mechanisms in neuroinflammation: An update from molecules to behavior | The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all neuropathology. Understanding the mechanisms that control the three st... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
643352 | Pathways, memory and information processing in matter | Imagine squeezing a crumpled plastic sheet – what is its response? For complex materials – crumpled sheets, granular media, glassy materials – tiny forces already cause a nonlinear response, associated with hopping in the energy landscape, for which we lack a coherent description. The central tenet of this proposal is ... | [
"Condensed Matter Physics",
"Materials Engineering",
"Computer Science and Informatics"
] |
W2015399519 | Surgical treatment of stress incontinence in men | The committee was charged with the responsibility of reviewing and evaluating all published data relating to surgical treatment of male urinary incontinence since the previous consultation in 2004.Articles from peer-reviewed journals, abstracts from scientific meetings, and literature searches by hand and electronicall... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physiology in Health, Disease and Ageing"
] |
10.5194/amt-8-2037-2015 | Airborne in situ vertical profiling of HDO / H<sub>2</sub><sup>16</sup>O in the subtropical troposphere during the MUSICA remote sensing validation campaign | . Vertical profiles of water vapor (H2O) and its isotope ratio D / H expressed as δD(H2O) were measured in situ by the ISOWAT II diode-laser spectrometer during the MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water (MUSICA) airborne campaign. We present recent modifications... | [
"Physical and Analytical Chemical Sciences",
"Earth System Science"
] |
10.1038/labinvest.2012.2 | Loss of angiotensin-converting enzyme 2 enhances TGF-Β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy | It is known that angiotensin (Ang)-converting enzyme (ACE) 2 catalyzes Ang II to Ang 1-7 to prevent the detrimental effect of Ang II on blood pressure, renal fibrosis, and inflammation. However, mechanisms of renoprotective role of Ace2 remain largely unclear. The present study tested the hypothesis that deficiency of ... | [
"Physiology in Health, Disease and Ageing",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1007/JHEP02(2016)052 | One Point Functions In Ads Dcft From Matrix Product States | One-point functions of certain non-protected scalar operators in the defect CFT dual to the D3-D5 probe brane system with k units of world volume flux can be expressed as overlaps between Bethe eig . . . | [
"Fundamental Constituents of Matter",
"Mathematics"
] |
W2053673091 | Estimates of Genetic Variability of <i>Mycobacterium tuberculosis</i> Complex and Its Association with Drug Resistance in Cameroon | The present study investigates the genetic diversity among Mycobacterium tuberculosis complex circulating in the Centre region of Cameroon and analyzes the relationship between genotypes and drug resistance patterns. Spoligotyping was performed by PCR-amplification followed by the reverse hybridization of 298 cultured ... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Immunity, Infection and Immunotherapy",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1103/PhysRevLett.119.040402 | Bell Inequalities Tailored to Maximally Entangled States | Bell inequalities have traditionally been used to demonstrate that quantum theory is nonlocal, in the sense that there exist correlations generated from composite quantum states that cannot be explained by means of local hidden variables. With the advent of device-independent quantum information protocols, Bell inequal... | [
"Fundamental Constituents of Matter",
"Computer Science and Informatics"
] |
W2785768012 | Fotokemijske i termičke transformacije diklor-supstituiranog butadienskog derivata | In order to study the influence of chlorine as a substituent on the thermal and photochemical behavior of conjugated butadiene systems, new dichloro derivative of butadiene 1 was synthesized by Wittig reaction. The new synthesized derivative 1 was exposed to thermal and photochemical reactions to prepare new unexplored... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1111/tpj.12488 | Strigolactones and the control of plant development: Lessons from shoot branching | Strigolactones (SLs) were originally identified through their activities as root exudates in the rhizosphere; however, it is now clear that they have many endogenous signalling roles in plants. In this review we discuss recent progress in understanding SL action in planta, particularly in the context of the regulation ... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1080/08940886.2017.1289799 | Local Maps Of Potential Energy Surfaces And Chemical Pathways | Potential energy surfaces are a central tool to rationalize, in a multidimensional system, how distortions along defined degrees of freedom link conformation and structural modifications to energy. The local and global mimima define stable conformations and the ground state. Crossings between the ground- and electronic... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics",
"Synthetic Chemistry and Materials"
] |
10.1016/j.celrep.2012.08.019 | Structural Basis for a Reciprocal Regulation between SCF and CSN | Skp1-Cul1-Fbox (SCF) E3 ligases are activated by ligation to the ubiquitin-like protein Nedd8, which is reversed by the deneddylating Cop9 signalosome (CSN). However, CSN also promotes SCF substrate turnover through unknown mechanisms. Through biochemical and electron microscopy analyses, we determined molecular models... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1093/cid/ciaa075 | Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance | Abstract
When H3N2 replaced H1N1 as the dominant influenza A subtype during the 2018–2019 season, the pattern of age-specific incidence shifted due to the lingering effects of antigenic imprinting. The characteristic shape that imprinting leaves on influenza susceptibility could foster important advances in understandi... | [
"Immunity, Infection and Immunotherapy",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1038/nature23013 | T<inf>FH</inf>-derived dopamine accelerates productive synapses in germinal centres | Protective high-affinity antibody responses depend on competitive selection of B cells carrying somatically mutated B-cell receptors by follicular helper T (TFH) cells in germinal centres. The rapid T-B-cell interactions that occur during this process are reminiscent of neural synaptic transmission pathways. Here we sh... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W4281794547 | Non-institutionalized frail elderly: are there any medications associated with falls? A case-control study. | Objetivo: Analisar a associação entre queda e o uso de medicamentos em idosos frágeis não institucionalizados.Materiais e Métodos: Trata-se de um estudo caso-controle realizado com usuários da Atenção Básica do Sistema Único de Saúde (SUS) na cidade de Divinópolis, interior de Minas Gerais, Brasil. Os casos eram idosos... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physiology in Health, Disease and Ageing"
] |
10.1038/srep22633 | Dragon kings of the deep sea: Marine particles deviate markedly from the common number-size spectrum | Particles are the major vector for the transfer of carbon from the upper ocean to the deep sea. However, little is known about their abundance, composition and role at depths greater than 2000 m. We present the first number-size spectrum of bathy- and abyssopelagic particles to a depth of 5500 m based on surveys perfo... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution"
] |
10.1109/ICASSP.2018.8462100 | Accounting For Room Acoustics In Audio Visual Multi Speaker Tracking | Multiple-speaker tracking is a crucial task for many applications. In real-world scenarios, exploiting the complementarity between auditory and visual data enables to track people outside the visual field of view. However, practical methods must be robust to changes in acoustic conditions, e. g. reverberation. We inve... | [
"Computer Science and Informatics",
"Systems and Communication Engineering"
] |
240132 | Spiking neural models of auditory perception | In classical connectionism, the information is conveyed by the firing rate of neurons. Spiking neuron models offer an additional dimension to the rate: synchrony. Synchronous spike trains are more effective than uncorrelated ones in driving the responses of target neurons. Because neurons can encode their inputs in a s... | [
"Neuroscience and Disorders of the Nervous System",
"Computer Science and Informatics",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1371/journal.pone.0066971 | Genome Analysis and Physiological Comparison of Alicycliphilus denitrificans Strains BC and K601<sup>T</sup> | The genomes of the Betaproteobacteria Alicycliphilus denitrificans strains BC and K601T have been sequenced to get insight into the physiology of the two strains. Strain BC degrades benzene with chlorate as electron acceptor. The cyclohexanol-degrading denitrifying strain K601T is not able to use chlorate as electron a... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Environmental Biology, Ecology and Evolution"
] |
219825 | Single-Cell multi-omics approach to study intra-tumour heterogeneity of soft tissue sarcomas | Recently, multi-omics approaches have led to a plethora of publications describing in detail the ‘omics landscapes of common cancer types. However, at the bulk tissue level, integrating different ‘omics layers remains an uncompleted challenge. Soft tissue sarcomas are rare and often aggressive cancers of mesenchymal or... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Cell Biology, Development, Stem Cells and Regeneration",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Computer Science and Informatics"
] |
W2472665424 | Modelling and simulation of direct solar radiation for cost-effectiveness analysis of V-Trough photovoltaic devices | In the urge to make solar energy competitive enough to directly face fossil fuels, several approaches result crucial for their intended capacity to maximise the energy that can be produced with a given photovoltaic area. Low Concentration Photovoltaics (LCPV) and tracking methods can be integrated in V-Trough solar dev... | [
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
10.1002/wnan.1462 | Antibodies from plants for bionanomaterials | Antibodies are produced as part of the vertebrate adaptive immune response and are not naturally made by plants. However, antibody DNA sequences can be introduced into plants, and together with laboratory technologies that allow the design of antibodies recognizing any conceivable molecular structure, plants can be use... | [
"Biotechnology and Biosystems Engineering",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Materials Engineering"
] |
10.1021/jp511953p | Gas adsorption and separation in realistic and idealized frameworks of organic pillared graphene: A comparative study | In this work, we present a systematic and thorough comparison between gas adsorption and energy storage properties in idealized or realistic models of organic-pillared reduced-graphene-oxide sheets. First, atomistic simulations based on density functional theory are used to generate the structures of these novel system... | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics",
"Materials Engineering"
] |
307023 | Inverse Problems in Partial Differential Equations and Geometry | Inverse problems research concentrates on the mathematical theory and practical interpretation of indirect measurements. Applications are found in virtually every research field involving scientific, medical, or industrial imaging and mathematical modelling. Familiar examples include X-ray Computed Tomography (CT) and ... | [
"Mathematics",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Earth System Science"
] |
174464 | Solution processed low-dimensional oxide semiconducting structures and devices | Progress in thin-film transistor (TFTs) over the past 40 years has been based primarily on the development/processing of new materials and on implementation of innovative device architectures together with new material combinations. The SUPERSOL project is a highly multidisciplinary research effort that aims to develop... | [
"Condensed Matter Physics",
"Materials Engineering",
"Synthetic Chemistry and Materials"
] |
10.1007/s00401-017-1796-5 | A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism | The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is still unclear. Two gain-of-function mechanisms are possible: repeat RNA toxicity and dipeptide repeat protein (DPR) toxicity. We here dissected both possibilitie... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1007/s00125-013-3118-3 | Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe <sup>-/-</sup> mice | Aims/hypothesis: Enhanced vascular inflammation, immune cell infiltration and elevated production of reactive oxygen species (ROS) contribute significantly to pro-atherogenic responses in diabetes. We assessed the immunomodulatory role of NADPH oxidase (NOX)-derived ROS in diabetes-accelerated atherosclerosis. Methods:... | [
"Immunity, Infection and Immunotherapy",
"Physiology in Health, Disease and Ageing",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1167/13.6.8 | Pupil Constrictions To Photographs Of The Sun | The pupil constricts in response to light increments and dilates with light decrements. Here we show that a picture of the sun, introducing a small overall decrease in light level across the field of view, results in a pupillary constriction. Thus, the pictorial representation of a high-luminance object (the sun) can o... | [
"Neuroscience and Disorders of the Nervous System",
"The Human Mind and Its Complexity"
] |
10.1371/journal.ppat.1002657 | Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis | Infectious endocytosis of incoming human papillomavirus type 16 (HPV-16), the main etiological agent of cervical cancer, is poorly characterized in terms of cellular requirements and pathways. Conflicting reports attribute HPV-16 entry to clathrin-dependent and -independent mechanisms. To comprehensively describe the c... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Immunity, Infection and Immunotherapy"
] |
10.1002/anie.201712186 | Visible-Light-Mediated Decarboxylative Radical Additions to Vinyl Boronic Esters: Rapid Access to γ-Amino Boronic Esters | The synthesis of alkyl boronic esters by direct decarboxylative radical addition of carboxylic acids to vinyl boronic esters is described. The reaction proceeds under mild photoredox catalysis and involves an unprecedented single-electron reduction of an α-boryl radical intermediate to the corresponding anion. The reac... | [
"Synthetic Chemistry and Materials",
"Physical and Analytical Chemical Sciences"
] |
EP 0004866 W | ACCESSORY FOR A TRANSANAL ACCESS SURGICAL INSTRUMENT AND, IN PARTICULAR, FOR A MECHANICAL CIRCULAR SUTURING DEVICE | An accessory, unusually capable of painless insertion of a transanal access surgical instrument and, in particular, a mechanical, circular suturing device, including a sleeve-shaped (90) inserter (86), said sleeve (90) having an annular section (98), designed to receive by sliding an operative extremity of said surgica... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.1016/j.pbi.2015.05.013 | Regulation of appressorium development in pathogenic fungi | Many plant pathogenic fungi have the capacity to breach the intact cuticles of their plant hosts using specialised infection cells called appressoria. These cells exert physical force to rupture the plant surface, or deploy enzymes in a focused way to digest the cuticle and plant cell wall. They also provide the means ... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration",
"Immunity, Infection and Immunotherapy"
] |
10.1126/science.abd0811 | Human NLRP1 is a sensor for double-stranded RNA | Inflammasomes function as intracellular sensors of pathogen infection or cellular perturbation and thereby play a central role in numerous diseases. Given the high abundance of NLRP1 in epithelial barrier tissues, we screened a diverse panel of viruses for inflammasome activation in keratinocytes. We identified Semliki... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W1632242929 | Diameter and Height Distributions of Natural Even-Aged Pine Forests (Pinus sylvestris) in Western Khentey, Mongolia | The purpose of this study was to find a suitable probability density function (PDF) to model the diameter at breast height (dbh) and height distributions of even-aged pine (Pinus sylvestris L.) forests. For the study, three different age-classes (AGs) of pine forests were used. Burr, Dagum, and Johnson SB distributions... | [
"Earth System Science",
"Mathematics"
] |
10.1042/bst20160395 | From molecular chaperones to membrane motors: through the lens of a mass spectrometrist | Twenty-five years ago, we obtained our first mass spectra of molecular chaperones in complex with protein ligands and entered a new field of gas-phase structural biology. It is perhaps now time to pause and reflect, and to ask how many of our initial structure predictions and models derived from mass spectrometry (MS) ... | [
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1088/1367-2630/17/9/093004 | Synergy Of Atom Probe Structural Data And Quantum Mechanical Calculations In A Theory Guided Design Of Extreme Stiffness Superlattices Containing Metastable Phases | A theory-guided materials design of nano-scaled superlattices containing metastable phases is critically important for future development of advanced lamellar composites with application-dictated stiffness and hardness. Our study combining theoretical and experimental methods exemplifies the strength of this approach f... | [
"Condensed Matter Physics",
"Materials Engineering",
"Synthetic Chemistry and Materials"
] |
10.1063/1.4820586 | Enhanced Spin Accumulation At Room Temperature In Graphene Spin Valves With Amorphous Carbon Interfacial Layers | We demonstrate a large enhancement of the spin accumulation in monolayer graphene following electron-beam induced deposition of an amorphous carbon layer at the ferromagnet-graphene interface. The enhancement is 104-fold when graphene is deposited onto poly(methyl metacrylate) (PMMA) and exposed with sufficient electro... | [
"Condensed Matter Physics",
"Materials Engineering"
] |
W4226271301 | Alheira | Among the processed pork products, one of the most traditional in Trás-os-Montes, Ne Portugal, is the alheira. Being a regional product it is consumed throughout the country, being part of Portuguese gastronomy. There are a large number of different brands, mostly commercial and three with PGI label, which can have dif... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.5194/acp-13-2391-2013 | Long term measurements of aerosol optical properties at a primary forest site in Amazonia | Abstract. A long term experiment was conducted in a primary forest area in Amazonia, with continuous in-situ measurements of aerosol optical properties between February 2008 and April 2011, comprising, to our knowledge, the longest database ever in the Amazon Basin. Two major classes of aerosol particles, with signific... | [
"Earth System Science",
"Physical and Analytical Chemical Sciences"
] |
10.1117/12.2292533 | Advancing flexible volatile compound sensors using liquid crystals encapsulated in polymer fibers | Until recently, organic vapor sensors using liquid crystals (LCs) have employed rigid glass substrates for confining the LC, and bulky equipment for vapor detection. Previously, we demonstrated that coaxially electrospinning nematic LC within the core of polymer fibers provides an alternative and improved form factor f... | [
"Condensed Matter Physics",
"Materials Engineering",
"Synthetic Chemistry and Materials"
] |
2723033 | Adaptable, compact and maintenance-free cooling systems for onboard equipment | CEDRION, a company incubated in the European Space Agency Business Incubation Centre (ESA-BIC) program, provides refrigerating solutions to the new demands in the electronics industry. More specifically, CEDRION -which has an international patent requested since April 2019 on its technology- designs and produces refrig... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
648379 | Learning to See in a Dynamic World | The goal of SEED is to fundamentally advance the methodology of computer vision by exploiting a dynamic analysis perspective in order to acquire accurate, yet tractable models, that can automatically learn to sense our visual world, localize still and animate objects (e.g. chairs, phones, computers, bicycles or cars, p... | [
"Computer Science and Informatics"
] |
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