id
stringlengths
6
42
title
stringlengths
3
499
abstract
stringlengths
0
6.24k
label
listlengths
0
6
10.1016/j.ymssp.2017.10.007
Efficient multidimensional regularization for Volterra series estimation
This paper presents an efficient nonparametric time domain nonlinear system identification method. It is shown how truncated Volterra series models can be efficiently estimated without the need of long, transient-free measurements. The method is a novel extension of the regularization methods that have been developed f...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
EP 18248109 A
QUATERNARY NICOTINAMIDE DERVIATIVES AS PRECURSORS FOR RELEASE OF MNA
The invention concerns pyridine salts derivatives which are O-substituted halides of 3-oxymethylaminocarbonyl-1-methylpyridine and their pharmaceutically acceptable salts. Disclosed compounds may be used as a medicament due to observed release of the active substance - N1-methylnicotinamide (MNA) by these compounds. Pr...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
W2900743499
Definition and Time Evolution of Correlations in Classical Statistical Mechanics
The study of dense gases and liquids requires consideration of the interactions between the particles and the correlations created by these interactions. In this article, the N-variable distribution function which maximizes the Uncertainty (Shannon’s information entropy) and admits as marginals a set of (N−1)-variable ...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Mathematics" ]
10.1109/TVT.2015.2483541
Spectral Efficient Bidirectional Decode And Forward Relaying For Full Duplex Communication
As a benefit of sophisticated interference cancelation techniques, full-duplex (FD) transceiver design may become feasible, even possibly on the aggressive time-scale of fifth-generation (5G) wireless communication systems. Hence, we further develop the recent bidirectional relaying [i. e. , the two-way half-duplex (HD...
[ "Systems and Communication Engineering", "Computer Science and Informatics" ]
10.1039/c9sm00428a
Light-regulated molecular diffusion in a liquid crystal network
Photo-responsive liquid crystal polymer networks offer promising means to generate useful functional devices, but many of them focus on their mechanical response so as to generate surface features or shape change. Here, we present the photomechanical effect of the polymer network for molecular transport purposes.
[ "Condensed Matter Physics", "Synthetic Chemistry and Materials", "Materials Engineering" ]
W2125799355
Measurement of Intraocular Pressure with Pressure Phosphene Tonometry in Children
To study the accuracy and acceptability of intraocular pressure (IOP) measurement by the pressure phosphene tonometer, non-contact tonometer, and Goldmann tonometer in children.Fifty children (5 to 14 years old) participated in this prospective comparative study. IOP was measured with the pressure phosphene tonometer, ...
[ "Prevention, Diagnosis and Treatment of Human Diseases", "Physiology in Health, Disease and Ageing" ]
864189
Music at the Frontiers of Artificial Creativity and Criticism
Artificial intelligence (AI) is an especially disruptive technology, impacting a growing number of domains in ways both beneficial and detrimental. It is even showing surprising impacts in the Arts, provoking questions fundamental to philosophy, law, and engineering, not to mention practices in the Arts themselves. MUS...
[ "Computer Science and Informatics", "Studies of Cultures and Arts", "The Human Mind and Its Complexity" ]
W2089511272
Hydrothermal carbonization of anaerobically digested maize silage
Hydrochars were prepared by hydrothermal carbonization (HTC) of maize silage previously treated at 55 °C in a two-stage solid-state reactor system. The HTC was carried out in a 1-L stirred pressure reactor with pH regulation by citric acid. The treated silage carbonized at relatively mild conditions (190 °C, 2 h), and ...
[ "Products and Processes Engineering", "Environmental Biology, Ecology and Evolution", "Materials Engineering" ]
W2000540363
Unilateral hearing during development: hemispheric specificity in plastic reorganizations
The present study investigates the hemispheric contributions of neuronal reorganization following early single-sided hearing (unilateral deafness). The experiments were performed on ten cats from our colony of deaf white cats. Two were identified in early hearing screening as unilaterally congenitally deaf. The remaini...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1007/978-3-319-05161-1_17
Modulation Of Trp Ion Channels By Venomous Toxins
Venoms are evolutionarily fine-tuned mixtures of small molecules, peptides, and proteins—referred to as toxins—that have evolved to specifically modulate and interfere with the function of diverse molecular targets within the envenomated animal. Many of the identified toxin targets are membrane receptors and ion channe...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physical and Analytical Chemical Sciences" ]
10.1016/j.cub.2013.10.038
Modeling framework for the establishment of the apical-basal embryonic axis in plants
The apical-basal axis of the early plant embryo determines the body plan of the adult organism. To establish a polarized embryonic axis, plants evolved a unique mechanism that involves directional, cell-to-cell transport of the growth regulator auxin. Auxin transport relies on PIN auxin transporters [1], whose polar su...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.actbio.2016.10.042
Microfluidic assembly of a nano-in-micro dual drug delivery platform composed of halloysite nanotubes and a pH-responsive polymer for colon cancer therapy
Harsh conditions of the gastrointestinal tract hinder the oral delivery of many drugs. Developing oral drug delivery systems based on commercially available materials is becoming more challenging due to the demand for simultaneously delivering physicochemically different drugs for treating complex diseases. A novel arc...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases", "Materials Engineering" ]
10.1084/jem.20151100
Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging
Dietary restriction (DR) improves health, delays tissue aging, and elongates survival in flies and worms. However, studies on laboratory mice and nonhuman primates revealed ambiguous effects of DR on lifespan despite improvements in health parameters. In this study, we analyzed consequences of adult-onset DR (24 h to 1...
[ "Physiology in Health, Disease and Ageing", "Immunity, Infection and Immunotherapy", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1088/0004-637X/810/1/49
The Final Parsec Problem In The Collisionless Limit
A binary supermassive black hole loses energy via ejection of stars in a galactic nucleus, until emission of gravitational waves becomes strong enough to induce rapid coalescence. Evolution via the gravitational slingshot requires that stars be continuously supplied to the binary, and it is known that in spherical gala...
[ "Universe Sciences", "Mathematics" ]
IN 2018050789 W
PROCESS FOR PREPARATION OF ENZALUTAMIDE USING NOVEL INTERMEDIATE
Process for preparation of Enzalutamide using novel intermediate Provided herein is a process for the preparation of a novel [4-cyano-3- (trifluoromethyl)phenyl]carbamodithioic acid and its use in preparation of Enzalutamide being cost effective with higher yield, higher HPLC purity with reduced impurities.
[ "Synthetic Chemistry and Materials", "Products and Processes Engineering" ]
10.1364/OPN.24.12.000055
Ultrafast Single Shot Measurements In Modulation Instability And Supercontinuum
The real-time measurement of ultrafast noisy processes is challenging because it requires single-shot resolution, broadband fidelity and long-record length. It is especially difficult to measure fluctuations in the optical supercontinuum, a white light source that can span over an octave in bandwidth.
[ "Physical and Analytical Chemical Sciences", "Systems and Communication Engineering" ]
W4283727521
Juan DÍAZ ÁLVAREZ (coord.), «Cultura académica y monarquía en el siglo XVIII», Gijón, Ediciones Trea, 2020, 319 págs.
Sin resumen.
[ "Texts and Concepts", "The Study of the Human Past", "Studies of Cultures and Arts" ]
W4289263243
RAZÃO E INTELECTO
O mundo sensível é conhecido por intermédio da nossa sensibilidade. Além da faculdade da sensibilidade, a pessoa humana possui também as faculdades da razão e do intelecto. No entanto, parece que nossa cultura do século XXI tenha perdido o sentido dessas duas faculdades; que tenha entendido que o intelecto nada mais se...
[ "Texts and Concepts" ]
10.1016/j.biomaterials.2011.09.030
Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats
Various attempts have been made to develop artificial conduits for nerve repair, but with limited success. We describe here conduits made from Bombyx mori regenerated silk protein, and containing luminal fibres of Spidrex ®, a silk-based biomaterial with properties similar to those of spider silk. Assessment in vitro d...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration", "Materials Engineering" ]
217673
Innovative production system for work boat catamarans
Catmarine Production System (CPS) delivers to the market work-boat catamaran conceived to fit several work-boats target markets, focusing on building flexibility and a high quality/price ratio. CPS combines together different construction technology; Motherboard Production System (MPS), Modular Moulding System (MMS) an...
[ "Products and Processes Engineering", "Materials Engineering" ]
W4392258766
On the narratives of the joys and aporias of individuation: the approximation of youth practices in the Brazilian popular neighborhoods
Les discussions proposées dans cet article se situent dans le cadre de la sociologie de la jeunesse et narrent des pratiques juvéniles dans des quartiers populaires, en vue de les articuler analytiquement à des processus d'individuation dans des contextes quotidiennement traversés de marqueurs d'inégalité sociale. Nous...
[ "The Social World and Its Interactions", "Texts and Concepts" ]
309540
Compensatory Evolution and Epistasis in Multidrug-resistant Mycobacterium tuberculosis
Multidrug-resistant bacteria are a global threat to public health and the economy. Studies in model organisms suggest compensatory evolution and epistatic interactions between drug resistance-conferring mutations are important drivers of drug resistance. However, the relevance of these factors for the emergence and tra...
[ "Immunity, Infection and Immunotherapy", "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Prevention, Diagnosis and Treatment of Human Diseases" ]
10.1007/JHEP02(2016)068
Evaluation Of Conformal Integrals
We present a comprehensive method for the evaluation of a vast class of integrals representing 3-point functions of conformal field theories in momentum space. The method leads to analytic, closed-form expressions for all scalar and tensorial 3-point functions of operators with integer dimensions in any spacetime dimen...
[ "Mathematics", "Fundamental Constituents of Matter" ]
10.1007/s11406-016-9726-7
Forgiveness, Representative Judgement and Love of the World: Exploring the Political Significance of Forgiveness in the Context of Transitional Justice and Reconciliation Debates
The article examines the political challenge and significance of forgiveness as an indispensable response to the inherently imperfect and tragic nature of political life through the lens of the existential, narrative-inspired judging sensibility. While the political significance of forgiveness has been broadly recogniz...
[ "Texts and Concepts", "Institutions, Governance and Legal Systems", "The Social World and Its Interactions" ]
W2495752092
CO<sub>2</sub>-full factorial optimization of an ultra-high performance concrete mix design
This article presents a factorial modelling, as well as an optimization, of the mix proportion of ultra-high performance concrete (UHPC) in terms of maximising the 28-day strength and minimising CO2 emissions. A full factorial design and desirability function optimization method were performed to find the best UHPC ing...
[ "Products and Processes Engineering", "Materials Engineering", "Environmental Biology, Ecology and Evolution" ]
294650
Oncogene-Induced DNA Damage in Cancer
I recently proposed a model that helps explain the presence of p53 mutations and genomic instability in human cancers (Nature, 2005; Nature 2006; Science 2008). The key features of this model are that oncogenes induce DNA replication stress, which in turn leads to DNA double-strand breaks, genomic instability and p53-i...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1016/j.neuron.2015.03.013
Lengthening of the stargazin cytoplasmic tail increases synaptic transmission by promoting interaction to deeper domains of PSD-95
PSD-95 is a prominent organizer of the postsynaptic density (PSD) that can present a filamentous orientation perpendicular to the plasma membrane. Interactions between PSD-95 and transmembrane proteins might be particularly sensitive to this orientation, as"long" cytoplasmic tails might be required to reach deeper PSD-...
[ "Neuroscience and Disorders of the Nervous System", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1007/jhep02(2020)039
Invisible and displaced dark matter signatures at Belle II
Abstract Many dark matter models generically predict invisible and displaced signatures at Belle II, but even striking events may be missed by the currently implemented search programme because of inefficient trigger algorithms. Of particular interest are final states with a single photon accompanied by missing energy ...
[ "Fundamental Constituents of Matter" ]
Q14722
AVL export support
The aim of the project is to support the participation in a series of international trade fairs between 2016 and 2018 (strengthening position on international markets, mainly European and Asian), the long-term competitiveness of the company in the high-pressure armaments market and metalworking. a.
[ "Individuals, Markets and Organisations", "Products and Processes Engineering" ]
10.1093/jxb/erw392
Companion cells: A diamond in the rough
Vascular plants have developed highly specialized cells to transport nutrients and developmental signals. The differentiation process includes the degradation of multiple organelles of the sieve element cells (SEs) to facilitate transport and, as a consequence, SEs become dependent on neighboring companion cells (CCs)....
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1103/PhysRevA.95.043426
Control of photoemission delay in resonant two-photon transitions
The photoelectron emission time delay τ associated with one-photon absorption, which coincides with half the Wigner delay τW experienced by an electron scattered off the ionic potential, is a fundamental descriptor of the photoelectric effect. Although it is hard to access directly from experiment, it is possible to in...
[ "Fundamental Constituents of Matter", "Physical and Analytical Chemical Sciences" ]
219742
Deciphering the mycobiome of indoor environments by high-throughput sequencing
Fungi have ubiquitous distribution in natural ecosystems and are also common in the built environment, where people spend major parts of their lifetime. When moisture is present, fungal growth can cause material deterioration and adverse effects on the occupant’s health. Traditional methods for analyzing the indoor myc...
[ "Environmental Biology, Ecology and Evolution", "Biotechnology and Biosystems Engineering", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1039/C5CP02145F
Anion Resonances And Above Threshold Dynamics Of Coenzyme Q0
Temporary radical anions (resonances) of isolated co enzyme Q0 (CQ0) and their associated above-threshold dynamics have been studied using frequency-, angle-, and time-resolved photoelectron imaging (FAT-PI). Experimental energetics and dynamics are supported with ab initio calculations. All results support that CQ0 ex...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
3740997
Towards comprehensive maps of tree structure and function: linking tree architecture, anatomy and physiology
There is a striking diversity of tree architectural and anatomical forms worldwide. The functional meaning of several conspicuous architectural and anatomical spectra, and their costs and benefits remain obscure. For example, it is unknown why some tree stems are composed of large portions of living cells while others ...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution" ]
10.1371/journal.pcbi.1002934
Measurements of the Impact of 3′ End Sequences on Gene Expression Reveal Wide Range and Sequence Dependent Effects
A full understanding of gene regulation requires an understanding of the contributions that the various regulatory regions have on gene expression. Although it is well established that sequences downstream of the main promoter can affect expression, our understanding of the scale of this effect and how it is encoded in...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1002/ecs2.3078
Disentangling local, metapopulation, and cross-community sources of stabilization and asynchrony in metacommunities
Asynchronous fluctuations of populations are essential for maintaining stable levels of biomass and ecosystem function in landscapes. Yet, understanding the stabilization of metacommunities by asynchrony is complicated by the existence of multiple forms of asynchrony that are typically studied independently: Community ...
[ "Environmental Biology, Ecology and Evolution" ]
Q4590164
Marketing support of MOCCA, spol. s r.o.
The subject of the proposed project is to support the individual repeated participation of MOCCA, spol. s r.o. at the ISM 2020, 2022 and ANUGA 2021 trade fairs held in Germany in Cologne in the period 2020-2022. It is a fair focused on the presentation of sweets and confectionery. The implementation of the project will...
[ "Individuals, Markets and Organisations" ]
EP 2007010166 W
FAS BLEACHING
The invention relates to lignin-preserving bleaching of lignocellulosic primary fibres produced by the action of sulfites, by means of formamidine sulfinic acid (FAS). The invention also relates to a bleached primary fibrous material consisting of lignocellulosic material produced by the action of sulfites. Primary fib...
[ "Products and Processes Engineering", "Materials Engineering" ]
W2946083570
Enabling multiscale modeling in systems medicine: From reactions in cells to organ physiology
Systems medicine is an interdisciplinary approach that integrates data from basic research and clinical practice to improve our understanding and treatment of diseases. Systems medicine can be seen as a further development of systems biology and bioinformatics towards applica-tions of clinical relevance. The term 'syst...
[ "Integrative Biology: from Genes and Genomes to Systems", "Physiology in Health, Disease and Ageing" ]
W2000803991
Prediction of the drug release stability of different polymeric matrix tablets containing metronidazole
The aim of the present study was to predict the structural changes of polymeric excipients in the course of storage causing undesired changes in drug release stability of tablets containing different polymers. Matrix tablets were formulated with metronidazole as a model drug, using polyvinylpyrrolidone and carbopol as ...
[ "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials", "Materials Engineering" ]
10.1038/s41588-018-0084-1
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes article
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2. 2 × 10-7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-f...
[ "Integrative Biology: from Genes and Genomes to Systems", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
175369
Exploring the human gut microbiome at strain resolution
With the genome sequencing of hundreds of bacterial isolates per day and a vast and growing number of metagenomic sequencing projects on gut microbiomes in healthy and diseased people all over the world, it becomes feasible to explore the microbial diversity in us not only at the level of genera and species, but at str...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Environmental Biology, Ecology and Evolution", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1021/jp507422s
(2 n × 1) reconstructions of TiO<inf>2</inf>(011) revealed by noncontact atomic force microscopy and scanning tunneling microscopy
We have used noncontact atomic force microscopy (NC-AFM) and scanning tunneling microscopy (STM) to study the rutile TiO2(011) surface. A series of (2n × 1) reconstructions were observed, including two types of (4 × 1) reconstruction. High-resolution NC-AFM and STM images indicate that the (4 × 1)-α phase has the same ...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1007/s00220-014-2008-y
Universality of one-dimensional fermi systems, i. Response functions and critical exponents
The critical behavior of one-dimensional interacting Fermi systems is expected to display universality features, called Luttinger liquid behavior. Critical exponents and certain thermodynamic quantities are expected to be related among each other by model-independent formulas. We establish such relations, the proof of ...
[ "Condensed Matter Physics", "Mathematics" ]
W4281960706
Host preference and survivorship of <i>Euschistus heros</i> (Hemiptera: Pentatomidae) strains on cotton and soybean
Abstract The Neotropical brown stink bug Euschistus heros (Fabricius) (Hemiptera: Pentatomidae) is a key pest of soybeans, Glycine max , and recently became an economically important pest of cotton, Gossypium hirsutum . This stink bug has two allopatric strains, one prevalent in southern Brazil (SS), and another in the...
[ "Environmental Biology, Ecology and Evolution" ]
10.1016/j.cortex.2014.11.009
Visual imagery influences brain responses to visual stimulation in bilateral cortical blindness
Mental imagery is a powerful mechanism that may facilitate visual perception as well as compensate for it. The role of V1 in mental imagery is still a matter of debate. Our goal here was to investigate whether visual imagery was still possible in case of bilateral V1 destruction behaviorally evidenced by total clinical...
[ "Neuroscience and Disorders of the Nervous System", "Physiology in Health, Disease and Ageing" ]
263643
Musical Transitions to European Colonialism in the eastern Indian Ocean
MUSTECIO's aim is to produce, for the first time, a history of transitions from pre-colonial to colonial musical fields in the eastern Indian Ocean. It will focus on India and the Malay peninsula, largely during the period of British expansion, c.1750-1900, and combine research methodologies from both history and ethno...
[ "The Study of the Human Past", "Studies of Cultures and Arts" ]
W2046640629
Fixed outline multi-bend bus driven floorplanning
Modern hierarchical SOC design flows need to deal with fixed-outline floorplanning under the interconnect constraints, in this paper, we address the problem of bus driven floorplanning in a fixed-outline area. Given a set of blocks, the bus specification, and the height and width of the chip area, a floorplan solution ...
[ "Computer Science and Informatics", "Systems and Communication Engineering" ]
10.1145/3328778.3366886
A Modular Practical Test For A Programming Course
In order to evaluate students' programming skills during a university course, a practical programming test can be administered, in which students are required to implement a short yet complete program according to a provided specification. However, such tests often suffer from drawbacks that prevent comprehensive and a...
[ "Computer Science and Informatics" ]
10.18632/oncotarget.19033
Inhibitor of growth protein 4 interacts with Beclin 1 and represses autophagy
Beclin 1 (BECN1) is a multifunctional protein that activates the proautophagic class III phosphatidylinositol 3-kinase (PIK3C3, best known as VPS34), yet also interacts with multiple negative regulators. Here we report that BECN1 interacts with inhibitor of growth family member 4 (ING4), a tumor suppressor protein that...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
683154
Wiring synaptic circuits with astroglial connexins: mechanisms, dynamics and impact for critical period plasticity
Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial elements of the brain circuitry that control synapse formation, maturation, activity and eliminat...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1063/1.4976690
Microfluidic Devices Fabricated Using Fast Wafer Scale Led Lithography Patterning
Current lithography approaches underpinning the fabrication of microfluidic devices rely on UV exposure of photoresists to define microstructures in these materials. Conventionally, this objective is achieved with gas discharge mercury lamps, which are capable of producing high intensity UV radiation. However, these so...
[ "Physical and Analytical Chemical Sciences", "Materials Engineering", "Products and Processes Engineering" ]
169910
Advertisement displays manufactured by hybrid in-mould integration
OptIntegral develops and demonstrates LED displays for advertisement manufactured by in-mould hybrid integration of TOLAE electronics and photonics components. The aim is to proof the flexibility and sustainability of the novel manufacturing process enabling a diversity of LED display products competitive with EU-labou...
[ "Products and Processes Engineering", "Materials Engineering", "Systems and Communication Engineering" ]
10.1103/PhysRevD.89.084012
Spinning fluids: A group theoretical approach
The aim of this article is to introduce a Lagrangian formulation of relativistic non-Abelian spinning fluids in group theory language. The corresponding Mathisson-Papapetrou equation for spinning fluids in terms of the reduction limit of the de Sitter group has been proposed. The equation we find correctly boils down t...
[ "Fundamental Constituents of Matter", "Mathematics" ]
10.1182/blood-2014-01-550467
Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
Key Points Liver-specific hepcidin KO mice fully recapitulate the severe iron overload phenotype observed in the total KO mice. The hepcidin produced by hepatocytes is the main regulator of body iron homeostasis.
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Physiology in Health, Disease and Ageing" ]
10.1017/S0305004119000252
Enumerating Coloured Partitions In 2 And 3 Dimensions
We study generating functions of ordinary and plane partitions coloured by the action of a finite subgroup of the corresponding special linear group. After reviewing known results for the case of ordinary partitions, we formulate a conjecture concerning a basic factorisation property of the generating function of colou...
[ "Mathematics" ]
10.1128/JB.00615-17
Translocation through the conjugative type IV secretion system requires unfolding of its protein substrate
Bacterial conjugation, a mechanism of horizontal gene transfer, is the major means by which antibiotic resistance spreads among bacteria (1, 2). Conjugative plasmids are transferred from one bacterium to another through a type IV secretion system (T4SS) in the form of single-stranded DNA covalently attached to a protei...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Immunity, Infection and Immunotherapy" ]
Q118253
Proporcionar una herramienta innovadora para apoyar la comunicación y el funcionamiento de cualquier proceso de negocio entre una empresa y un contratista externo en la nube
Como parte del proyecto, la compañía planea crear una herramienta innovadora para crear y automatizar procesos de negocio en empresas principalmente en el sector PYME. La solución permitirá acelerar la implementación de la integración entre empresas, así como la integración de la relación emprendedor-cliente final. De ...
[ "Products and Processes Engineering", "Computer Science and Informatics" ]
W185452566
STATISTICAL METHODS | Data Analysis
A sequence of data entries is called a time series. Most time series have a random character. A time series where there is no correlation from one member of the series to another is called white noise . Models of time series can be constructed from white noise by having each new entry a sum of a white noise contributio...
[ "Mathematics" ]
10.1016/j.chom.2015.01.011
Structure and function of the bacterial root microbiota in wild and domesticated barley
The microbial communities inhabiting the root interior of healthy plants, as well as the rhizosphere, which consists of soil particles firmly attached to roots, engage in symbiotic associations with their host. To investigate the structural and functional diversification among these communities, we employed a combinati...
[ "Environmental Biology, Ecology and Evolution", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1172/JCI58109
Gut Microbiome Obesity And Metabolic Dysfunction
The prevalence of obesity and related disorders such as metabolic syndrome has vastly increased throughout the world. Recent insights have generated an entirely new perspective suggesting that our microbiota might be involved in the development of these disorders. Studies have demonstrated that obesity and metabolic sy...
[ "Physiology in Health, Disease and Ageing", "Integrative Biology: from Genes and Genomes to Systems", "Environmental Biology, Ecology and Evolution" ]
10.1007/978-1-4939-2522-3_16
Stress Responses During Ageing Molecular Pathways Regulating Protein Homeostasis
The ageing process is characterized by deterioration of physiological function accompanied by frailty and ageing-associated diseases. The most broadly and well-studied pathways influencing ageing are the insulin/insulin-like growth factor 1 signaling pathway and the dietary restriction pathway. Recent studies in divers...
[ "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.15252/embj.2018100056
Conformational dynamics of the ABC transporter McjD seen by single-molecule FRET
ABC transporters utilize ATP for export processes to provide cellular resistance against toxins, antibiotics, and harmful metabolites in eukaryotes and prokaryotes. Based on static structure snapshots, it is believed that they use an alternating access mechanism, which couples conformational changes to ATP binding (out...
[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.18632/aging.100897
NKG2D ligands mediate immunosurveillance of senescent cells
Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. Induction of cellular senescence commonly coincides with an immunogenic phenotype that promotes self-elimination by components of the immune system, thereby facilitating tumor suppression and limiting excess fibrosis during ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Immunity, Infection and Immunotherapy" ]
10.1016/j.devcel.2011.05.013
Inositol trisphosphate-induced ca<sup>2+</sup> signaling modulates auxin transport and pin polarity
The phytohormone auxin is an important determinant of plant development. Directional auxin flow within tissues depends on polar localization of PIN auxin transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphat...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W1995995262
Autonomous interfacial creation of nanostructured lead oxide
We first established a process for the autonomous creation of PbO nanostructures consisting of a simple three-step procedure for both the formation of Pb nanoparticles and their oxidation. Oxygen contacting aqueous media results in an autonomous conversion from electrodeposited Pb particles to PbO nanostructures; i) fl...
[ "Physical and Analytical Chemical Sciences", "Condensed Matter Physics", "Synthetic Chemistry and Materials" ]
10.1039/C9OB01209E
A Chemical Approach For The Synthesis Of The Dna Binding Domain Of The Oncoprotein Myc
We describe the first chemical synthesis of a functional mutant of the DNA binding domain of the oncoprotein MYC, using two alternative strategies which involve either one or two Native Chemical Ligations (NCLs). Both routes allowed the efficient synthesis of a miniprotein which is capable of heterodimerizing with MAX,...
[ "Synthetic Chemistry and Materials", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1039/C4OB02060J
Cell Penetrating Poly Disulfide S The Dependence Of Activity Depolymerization Kinetics And Intracellular Localization On Their Length
We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.
[ "Physical and Analytical Chemical Sciences", "Molecules of Life: Biological Mechanisms, Structures and Functions", "Cell Biology, Development, Stem Cells and Regeneration" ]
10.1088/0953-8984/26/22/225801
Electronic Structure And Local Distortions In Epitaxial Scgan Films
High energy resolution fluorescence-detected x-ray absorption spectroscopy and density functional theory calculations were used to investigate the local bonding and electronic structure of Sc in epitaxial wurtzite-structure ScxGa1?xN films with x???0. 059. Sc atoms are found to substitute for Ga atoms, accompanied by a...
[ "Condensed Matter Physics", "Physical and Analytical Chemical Sciences", "Synthetic Chemistry and Materials" ]
10.1002/ece3.1274
A phylogenetic analysis of the British flora sheds light on the evolutionary and ecological factors driving plant invasions
Summary: Darwin's naturalization hypothesis predicts that invasive species should perform better in their novel range in the absence of close relatives in the native flora due to reduced competition. Evidence from recent taxonomic and phylogenetic-based studies, however, is equivocal. We test Darwin's naturalization hy...
[ "Environmental Biology, Ecology and Evolution", "Earth System Science" ]
W218885361
A millennium-long management perspective for promoting the geological-social resiliency of barrier islands: a preliminary proposal for Fire Island, NY
Barrier islands, such as Fire Island, NY, are complex geological-social systems, driven by mesoscale (centuries/ millennia) processes. The natural resiliency of these thin, linear landforms depends mainly on their capacity to migrate land- ward (rollover) in response to the slow, persistent rise of sea level. This happ...
[ "Earth System Science", "Products and Processes Engineering" ]
10.1093/bioinformatics/bty1065
Characterizing and ranking computed metabolic engineering strategies
MotivationThe computer-aided design of metabolic intervention strategies has become a key component of an integrated metabolic engineering approach and a broad range of methods and algorithms has been developed for this task. Many of these algorithms enforce coupling of growth with product synthesis and may return thou...
[ "Computer Science and Informatics", "Integrative Biology: from Genes and Genomes to Systems", "Products and Processes Engineering" ]
10.1108/978-1-78769-415-620191005
Children Negotiating Their Place Through Space In Multi Local Joint Physical Custody Arrangements
This chapter focusses on multi-local families and more specifically on the ways in which children of separated parents, living in joint physical custody arrangements, define and construct their ‘home’ in a context of circular mobility. It is based on two case studies drawn from ongoing fieldwork conducted in Belgium wi...
[ "Human Mobility, Environment, and Space", "The Social World and Its Interactions" ]
169532
Language activation and control in the unimodal and bimodal bilingual lexicon
Bilinguals activate words from both languages when listening, reading or speaking in one language, and engage non-linguistic cognitive control abilities to resolve cross-linguistic competition. Most studies of cross-language activation have focused on activation between languages through overlapping phonological repres...
[ "The Human Mind and Its Complexity", "Neuroscience and Disorders of the Nervous System" ]
10.1109/TPAMI.2016.2574706
An Efficient Multilinear Optimization Framework For Hypergraph Matching
Hypergraph matching has recently become a popular approach for solving correspondence problems in computer vision as it allows the use of higher-order geometric information. Hypergraph matching can be formulated as a third-order optimization problem subject to assignment constraints which turns out to be NP-hard. In re...
[ "Computer Science and Informatics", "Mathematics" ]
W2173720115
Hot-cavity studies for the Resonance Ionization Laser Ion Source
The Resonance Ionization Laser Ion Source (RILIS) has emerged as an important technique in many Radioactive Ion Beam (RIB) facilities for its reliability, and ability to ionize target elements efficiently and element selectively. GISELE is an off-line RILIS test bench to study the implementation of an on-line laser ion...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.3934/nhm.2016.11.145
Entropy stability and well-balancedness of space-time dg for the shallow water equations with bottom topography
We describe a shock-capturing streamline diffusion space-time dis-continuous Galerkin (DG) method to discretize the shallow water equations with variable bottom topography. This method, based on the entropy variables as degrees of freedom, is shown to be energy stable as well as well-balanced with respect to the lake a...
[ "Mathematics" ]
10.1007/978-3-319-68288-4_21
Computing Fo Rewritings In El In Practice From Atomic To Conjunctive Queries
A prominent approach to implementing ontology-mediated queries (OMQs) is to rewrite into a first-order query, which is then executed using a conventional SQL database system. We consider the case where the ontology is formulated in the description logic EL and the actual query is a conjunctive query and show that rewri...
[ "Computer Science and Informatics", "Mathematics" ]
W3037271527
Bi-center problem and Hopf cyclicity of a Cubic Liénard system
In this paper we investigate the bi-center problem and the total Hopf cyclicity of two center-foci for the general cubic Lienard system which has three distinct equilibria and is equivalent to the general Lienard equation with cubic damping and restoring force. The location of these three equilibria is arbitrary, speci...
[ "Mathematics" ]
US 82090586 A
Spelling verification system with immediate operator alerts to non-matches between inputted words and words stored in plural dictionary memories
Spelling errors are detected through the comparison of the keyed word with previously stored words of known spelling. The operator is immediately alerted upon the detection of a lack of comparison between the keyed word and the words available in the storage for operator consideration. When the operator is notified thr...
[ "Computer Science and Informatics" ]
714774
Reconstructing a dated tree of life using phylogenetic incongruence
With the advent of genome-scale sequencing, molecular phylogeny, which reconstructs gene trees from homologous sequences, has reached an impasse. Instead of answering open questions, new genomes have reignited old debates. The problem is clear, gene trees are not species trees, each is the unique result of series of ev...
[ "Integrative Biology: from Genes and Genomes to Systems", "Environmental Biology, Ecology and Evolution", "Computer Science and Informatics" ]
638730
Development of functional organization of the visual circuits in mice
The key organizing principles that characterize neuronal systems include asymmetric, parallel, and topographic connectivity of the neural circuits. The main aim of my research is to elucidate the key principles underlying functional development of neural circuits by focusing on those organizing principles. I choose mou...
[ "Neuroscience and Disorders of the Nervous System", "Cell Biology, Development, Stem Cells and Regeneration" ]
interreg_1312
Euromountains.net - 'La mise en réseau des régions de montagne européennes pour la promotion d'un développement territorial durable'
Mountain services (infrastructure, ITC, social/health services, cultural services): common criteria for drawing up inventories, definition of quality and quantity markers, situation in the 13 test areas, identification of transferable successes and innovative solutions; proposed political recommendations at local and E...
[ "Earth System Science", "Human Mobility, Environment, and Space", "Products and Processes Engineering" ]
10.1109/TUFFC.2015.006996
Acoustic Output Of Multi Line Transmit Beamforming For Fast Cardiac Imaging A Simulation Study
Achieving higher frame rates in cardiac ultrasound could unveil short-lived myocardial events and lead to new insights on cardiac function. Multi-line transmit (MLT) beamforming (i. e. , simultaneously transmitting multiple focused beams) is a potential approach to achieve this. However, two challenges come with it: fi...
[ "Condensed Matter Physics", "Products and Processes Engineering" ]
W2492234549
Arabic text summarization based on graph theory
Automatic text summarization is a process of reducing the length of original document without affecting the content by extracting important information from huge amount of text data. The main goal is to facilitate the task of reading and searching information in large documents. Text summarization is the most challengi...
[ "Computer Science and Informatics" ]
W4311945515
“Todo cambia, todo sigue igual”. La gobernanza de la mano de obra migrante en la agricultura española e italiana en el primer año de la pandemia de Covid-19
La pandemia de la COVID-19 junto con las políticas adoptadas para contener la propagación del virus, tensionaron profundamente las cadenas de suministro de alimentos. En ello, la temprana escasez de mano de obra en la agricultura surgida a raíz de estos acontecimientos en España e Italia puso de manifiesto el papel ese...
[ "Institutions, Governance and Legal Systems", "The Social World and Its Interactions", "Human Mobility, Environment, and Space" ]
10.1371/journal.pgen.1007969
Transcription-driven chromatin repression of Intragenic transcription start sites
Progression of RNA polymerase II (RNAPII) transcription relies on the appropriately positioned activities of elongation factors. The resulting profile of factors and chromatin signatures along transcription units provides a “positional information system” for transcribing RNAPII. Here, we investigate a chromatin-based ...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Integrative Biology: from Genes and Genomes to Systems" ]
10.1039/C3CP54715A
On The Gas Phase Reaction Between So2 And O2 H2O 0 3 Clusters An Ab Initio Study
We present an ab initio investigation of the gas-phase reaction between SO2 and a O2−(H2O)n molecular cluster, n = 0–3. The associative product cluster, O2SO2−(H2O)n, is formed with high energy gain although the binding energies decrease with increasing hydration. About 54 kcal mol−1 may be gained by isomerization of O...
[ "Physical and Analytical Chemical Sciences", "Fundamental Constituents of Matter" ]
10.1016/j.isci.2020.100887
Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response
Activation of the hexosamine pathway (HP) through gain-of-function mutations in its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) ameliorates proteotoxicity and increases lifespan in Caenorhabditis elegans. Here, we investigate the role of the HP in mammalian protein quality control. In ...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
W1730013808
”Det kunde lika gärna ha hänt idag” : Maj Bylocks Drakskeppstrilogi och historiemedvetande hos barn i mellanåldrarna
The aim of this thesis, The Historical Novel and Historical Consciousness in ten- to twelve-year-olds - Maj Bylocks Drakskeppstrilogi in Theory and Practice, is to illustrate the possibilities for pupils of the ages between ten to twelve to develop their historical consciousness by participating in classroom work makin...
[ "The Study of the Human Past", "Texts and Concepts" ]
10.1111/1365-2656.13307
Detecting And Quantifying Social Transmission Using Network Based Diffusion Analysis
Although social learning capabilities are taxonomically widespread, demonstrating that freely interacting animals (whether wild or captive) rely on social learning has proved remarkably challenging. Network-based diffusion analysis (NBDA) offers a means for detecting social learning using observational data on freely i...
[ "Computer Science and Informatics", "The Social World and Its Interactions", "Mathematics" ]
10.1038/ncomms13021
Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10
The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology pr...
[ "Cell Biology, Development, Stem Cells and Regeneration", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
interreg_319
Sustainable management and tourist promotion of natural and archaeological heritage in the Adriatic Caves
Fascinating, mysterious, enchanting: the caves are an attractor factor of tourist flows. ADRION area is well established tourism destination with intensive short summer season, but limited tourism in other parts of the year. However, potentials for developing all year tourism destinations are many and natural, cultural...
[ "Earth System Science", "Environmental Biology, Ecology and Evolution", "Human Mobility, Environment, and Space" ]
10.1103/PhysRevLett.124.100402
Classification of Matrix-Product Unitaries with Symmetries
We prove that matrix-product unitaries with on-site unitary symmetries are completely classified by the (chiral) index and the cohomology class of the symmetry group G, provided that we can add trivial and symmetric ancillas with arbitrary on-site representations of G. If the representations in both system and ancilla...
[ "Condensed Matter Physics", "Mathematics" ]
10.1016/j.cub.2017.06.054
Shoot–Root Communication in Flowering Plants
As sessile organisms, terrestrial plants have evolved sophisticated mechanisms to coordinate the growth and development of two distinct systems, the shoot and the root, in response to environmental fluctuations. Adaptive systemic responses are accomplished by shoot–root communication, which involves diverse long-distan...
[ "Molecules of Life: Biological Mechanisms, Structures and Functions", "Environmental Biology, Ecology and Evolution" ]
10.1088/1475-7516/2015/07/001
The Effect Of Massive Neutrinos On The Bao Peak
We study the impact of neutrino masses on the shape and height of the BAO peak of the matter correlation function, both in real and redshift space. In order to describe the nonlinear evolution of the BAO peak we run N-body simulations and compare them with simple analytic formulae. We show that the evolution with redsh...
[ "Universe Sciences", "Fundamental Constituents of Matter" ]
10.1183/09031936.00017810
Osteopontin Expression And Relation To Disease Severity In Human Asthma
Recent studies have associated osteopontin (OPN) with allergic inflammation; however, its role in human asthma remains unclear. The aim of this study was to measure OPN levels in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of healthy controls and asthmatics, identify cellular sources of OPN and ...
[ "Immunity, Infection and Immunotherapy", "Physiology in Health, Disease and Ageing", "Molecules of Life: Biological Mechanisms, Structures and Functions" ]
10.1063/1.5008476
Design Optimization Of A Compact Photonic Crystal Microcavity Based On Slow Light And Dispersion Engineering For The Miniaturization Of Integrated Mode Locked Lasers
We exploit slow light (high ng) modes in planar photonic crystals in order to design a compact cavity, which provides an attractive path towards the miniaturization of near-infrared integrated fast pulsed lasers. By applying dispersion engineering techniques, we can design structures with a low dispersion, as needed by...
[ "Systems and Communication Engineering", "Condensed Matter Physics", "Physical and Analytical Chemical Sciences" ]
10.1016/j.alcr.2016.10.003
The long arm of childhood circumstances on health in old age: Evidence from SHARELIFE
Socioeconomic status (SES) and health during childhood have been consistently observed to be associated with health in old age in many studies. However, the exact mechanisms behind these two associations have not yet been fully understood. The key challenge is to understand how childhood SES and health are associated. ...
[ "Physiology in Health, Disease and Ageing", "The Social World and Its Interactions" ]
10.1088/1751-8121/ab7b21
Volume of the set of LOCC-convertible quantum states
The class of quantum operations known as local operations and classical communication (LOCC) induces a partial ordering on quantum states. We present the results of systematic numerical computations related to the volume (with respect to the unitarily invariant measure) of the set of LOCC-convertible bipartite pure sta...
[ "Fundamental Constituents of Matter", "Mathematics" ]