id stringlengths 6 42 | title stringlengths 3 499 | abstract stringlengths 0 6.24k | label listlengths 0 6 |
|---|---|---|---|
10.1088/0965-0393/24/2/025005 | An interatomic pair potential with tunable intrinsic ductility | A family of interatomic potentials is constructed for which the intrinsic ductility can be tuned systematically. Specifically, the elastic constants and critical energy release rate for Griffith cleavage, GIc, are held constant, while the critical energy release rate for dislocation emission, GIc, can be varied. This b... | [
"Condensed Matter Physics",
"Materials Engineering"
] |
10.1371/journal.pmed.1001484 | Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions | Background:The global burden of sickle cell anaemia (SCA) is set to rise as a consequence of improved survival in high-prevalence low- and middle-income countries and population migration to higher-income countries. The host of quantitative evidence documenting these changes has not been assembled at the global level. ... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Integrative Biology: from Genes and Genomes to Systems",
"Human Mobility, Environment, and Space"
] |
10.1016/j.palaeo.2013.09.019 | Mountain building and the initiation of the greenland ice sheet | The effects of a new hypothesis about mountain building in Greenland on ice sheet initiation are investigated using an ice sheet model in combination with a climate model. According to this hypothesis, low-relief landscapes near sea level characterised Greenland in Miocene times until two phases of km-scale uplift in t... | [
"Earth System Science"
] |
10.1039/C5TA01224D | Morphology And Local Electrical Properties Of Ptb7 Pc71Bm Blends | The power conversion efficiency of single layer organic solar cells can approach 10% with blends such as the polymer PTB7 and the fullerene derivative PC71BM. Here the detailed structure of PTB7:PC71BM blends deposited with and without addition of diiodooctane is studied by transmission electron microscopy and scanning... | [
"Condensed Matter Physics",
"Synthetic Chemistry and Materials",
"Materials Engineering"
] |
278636 | Pliocene Constraints on Earth System Sensitivity | The magnitude of long-term global temperature rise due to an increasing concentration of carbon dioxide (CO2) in the atmosphere is a question of relevance to policy makers and society. Previous studies have addressed this issue on the basis of the equilibrium response of the climate system due to fast feedbacks such as... | [
"Earth System Science",
"Environmental Biology, Ecology and Evolution"
] |
10.1002/hep.24489 | Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees | Understanding the immunological correlates associated with protective immunity following hepatitis C virus (HCV) reexposure is a prerequisite for the design of effective HCV vaccines and immunotherapeutics. In this study we performed a comprehensive analysis of innate and adaptive immunity following HCV reexposure of t... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
CH 9200125 W | OSTEOSYNTHETIC FIXATION DEVICE | The osteosynthetic fixation device consists of a securing component (1) having a conical head section (11) and an adjoining anchoring component (13) designed for fixing in the bone, and a spherical segment-shaped slotted clamping component (2) with a conical bore (21) to receive the conical head section (11) to clamp i... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
10.1038/s41598-019-51326-2 | Development and application of affordable SNP typing approaches to genotype Mycobacterium tuberculosis complex strains in low and high burden countries | The Mycobacterium tuberculosis complex (MTBC) comprises the species that causes tuberculosis (TB) which affects 10 million people every year. A robust classification of species, lineages, and sub-lineages is important to explore associations with drug resistance, epidemiological patterns or clinical outcomes. We presen... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Immunity, Infection and Immunotherapy",
"Biotechnology and Biosystems Engineering"
] |
175567 | 3D printing of cell laden biomimetic materials and biomolecules for joint regeneration | Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hos... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Materials Engineering"
] |
10.1016/j.bios.2018.03.011 | Disposable electrochemical detection of breast cancer tumour marker CA 15-3 using poly(Toluidine Blue) as imprinted polymer receptor | In this work, electrically-conducting poly(Toludine Blue) was employed for the first time as synthetic receptor film, prepared by Molecular Imprinting strategies and using electrochemical methods, for the specific screening of breast cancer biomarker Carbohydrate Antigen 15-3 (CA 15-3). The protein imprinted poly(Tolui... | [
"Physical and Analytical Chemical Sciences",
"Prevention, Diagnosis and Treatment of Human Diseases",
"Materials Engineering"
] |
10.1093/pcp/pcz078 | Biosynthesis of Long Chain Alkyl Diols and Long Chain Alkenols in Nannochloropsis spp. (Eustigmatophyceae) | AbstractWe investigated potential biosynthetic pathways of long chain alkenols (LCAs), long chain alkyl diols (LCDs), and long chain hydroxy fatty acids (LCHFAs) in Nannochloropsis oceanica and Nannochloropsis gaditana, by combining culturing experiments with genomic and transcriptomic analyses. Incubation of Nannochlo... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Biotechnology and Biosystems Engineering",
"Environmental Biology, Ecology and Evolution"
] |
W622619352 | CYCLIN-DEPENDENT KINASE G2 regulates salinity stress response and salt mediated flowering in Arabidopsis thaliana | Cyclin-dependent protein kinases are involved in many crucial cellular processes and aspects of plant growth and development, but their precise roles in abiotic stress responses are largely unknown. Here, Arabidopsis thaliana CYCLIN-DEPENDENT KINASE G2 (CDKG2) was shown to act as a negative regulator of the salinity st... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Environmental Biology, Ecology and Evolution"
] |
10.1016/j.molcel.2017.08.016 | SAGA Is a General Cofactor for RNA Polymerase II Transcription | Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA. We reassessed the role of SAGA by mapping its genome-wide location and role in global transcription in budding yeast. We find that SAGA maps to t... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems"
] |
interreg_708 | “COmmunity Nurse Supporting Elderly iN a changing SOciety” | European population’s ageing challenges health and social services. Cooperation in several welfare sectors is required, since the demographic change involves both health and social issues. CO.N.S.E.N.SO project accepts the challenge by developing a care model that puts the elderly at the centre of health and social ser... | [
"Physiology in Health, Disease and Ageing",
"The Social World and Its Interactions",
"Human Mobility, Environment, and Space"
] |
10.1039/c3sm52378k | Poly(3-hexylthiophene) nanowires in porous alumina: Internal structure under confinement | We study the structure of poly(3-hexylthiophene) (P3HT) subjected to nanoscale confinement in two dimensions (2D) as imposed by the rigid walls of nanopore anodic aluminum oxide (AAO) templates. P3HT nanowires with aspect ratios (length-to-diameter) above 1000 and diameters ranging between 15 nm and 350 nm are produced... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials",
"Materials Engineering"
] |
W3022774600 | Pandemic Recession: L or V-Shaped? | We develop and calibrate a search-theoretic model of the labor market in order to forecast the evolution of the aggregate US labor market during and after the coronavirus pandemic. The model is designed to capture the heterogeneity of the transitions of individual workers across states of unemployment, employment and a... | [
"Individuals, Markets and Organisations"
] |
10.1523/JNEUROSCI.1747-14.2014 | Excitatory Effects Of Parvalbumin Expressing Interneurons Maintain Hippocampal Epileptiform Activity Via Synchronous Afterdischarges | Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer clonic phase that is characterized by rhythmic bouts of synchronized network activity called afterdischarges (ADs). Here we investi... | [
"Neuroscience and Disorders of the Nervous System",
"Cell Biology, Development, Stem Cells and Regeneration",
"Physiology in Health, Disease and Ageing"
] |
10.1042/BST20130234 | Mitochondrial Trafficking In Neurons And The Role Of The Miro Family Of Gtpase Proteins | Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a precisely distributed and healthy mitochondrial network, so that local energy demands or Ca2+-buffering requirements within the intricate architecture of the ne... | [
"Neuroscience and Disorders of the Nervous System",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.1109/ICTON.2018.8473622 | Thermally Stable External Cavity Laser Based On Silicon Nitride Periodic Nanostructures | In this paper we demonstrate a thermally stable silicon nitride external cavity (SiN EC) laser based on a 250 μm sized Reflective Semiconductor Optical Amplifier (RSOA) butt-coupled to a series of Si 3 N 4 Bragg gratings acting as wavelength selective reflectors. The laser shows power outputs over 3 mW, a very low lasi... | [
"Systems and Communication Engineering",
"Condensed Matter Physics"
] |
EP 2008004965 W | COMPOSITE FIBER, TEXTILE PRODUCT COMPRISING SUCH A COMPOSITE FIBER, METHOD FOR INSCRIBING OPTICAL CODE ELEMENTS, ARRANGEMENT FOR CARRYING OUT SAID METHOD, AND READING DEVICE | In order to make textile products (32) counterfeit-proof, a composite fiber is disclosed which comprises a core (2) extending at least along part of the fiber length and a shell (3) surrounding the core (2). The shell is made of a plastic which can be locally modified, especially melted, with the help of light radiatio... | [
"Materials Engineering",
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
10.1364/OE.24.000092 | Optimization Of A Nanotip On A Surface For The Ultrafast Probing Of Propagating Surface Plasmons | We theoretically analyze a method for characterizing propagating surface plasmon polaritons (SPPs) on a thin gold film. The SPPs are excited by few-cycle near-infrared pulses using Kretschmann coupling, and a nanotip is used as a local field sensor. This geometry removes the influence of the incident excitation laser f... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
W2032434317 | Efficient assignment respecting priorities | Abstract A widespread practice in assignment of heterogeneous indivisible objects is to prioritize some recipients over others depending on the type of the object. Leading examples include assignment of public school seats, and allocation of houses, courses, or offices. Each object comes with a coarse priority ranking ... | [
"Computer Science and Informatics",
"Individuals, Markets and Organisations"
] |
10.1016/j.jclepro.2019.119755 | China's sustainable water-energy-food nexus by 2030: Impacts of urbanization on sectoral water demand | In the context of China's rapid and perennial urbanization, it is of profound importance to understand how to enable and accelerate progress towards achieving the country's sustainable water-energy-food nexus by 2030. In this study, a quantitative spatial scenario analysis was performed to identify the provinces that a... | [
"Earth System Science",
"Human Mobility, Environment, and Space",
"Products and Processes Engineering"
] |
10.1038/nature11923 | CLP1 links tRNA metabolism to progressive motor-neuron loss | CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo function has been elusive. Here we generated kinase-dead Clp1 (Clp1K/K) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of neuromuscular junct... | [
"Neuroscience and Disorders of the Nervous System",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.1088/0953-4075/49/7/074003 | The Virtual Atomic And Molecular Data Centre Vamdc Consortium | The Virtual Atomic and Molecular Data Centre (VAMDC) Consortium is a worldwide consortium which federates atomic and molecular databases through an e-science infrastructure and an organisation to support this activity. About 90% of the inter-connected databases handle data that are used for the interpretation of astron... | [
"Fundamental Constituents of Matter",
"Universe Sciences",
"Computer Science and Informatics"
] |
W1520706115 | Adolescent childbearing experiences in Kenya : geographical and socioeconomic determinants | Sub-Saharan Africa has one of the highest level of teenage pregnancies in the world. Some studies on this topic highlight the presence of unmet reproductive health needs of adolescent in different regions. Improving maternal health has been established as a key development priority among the Millennium Development Goal... | [
"Human Mobility, Environment, and Space",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1109/CCA.2012.6402682 | Identification Of A Pulsatile Endocrine Model From Hormone Concentration Data | This paper presents two approaches to estimate parameters of a mathematical model of a bipartite endocrine axis. Secretion of one of the involved hormones is stimulated by the concentration of another one, with the latter secreted in a pulsatile manner. The system output can be modeled as the response of a linear time-... | [
"Mathematics",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
10.1080/09500340.2014.920934 | Advanced Technologies For Future Ground Based Laser Interferometric Gravitational Wave Detectors | We present a review of modern optical techniques being used and developed for the field of gravitational wave detection. We describe the current state-of-the-art of gravitational waves detector technologies with regard to optical layouts, suspensions and test masses. We discuss the dominant sources and noise in each of... | [
"Universe Sciences",
"Fundamental Constituents of Matter"
] |
10.1093/nar/gku1043 | euL1db: The European database of L1HS retrotransposon insertions in humans | Retrotransposons account for almost half of our genome. They are mobile genetics elements-also known as jumping genes-but only the L1HS subfamily of Long Interspersed Nuclear Elements (LINEs) has retained the ability to jump autonomously in modern humans. Their mobilization in germline-but also some somatic tissues-con... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Computer Science and Informatics"
] |
10.1098/rspb.2014.1195 | Effects of deception in social networks | Honesty plays a crucial role in any situation where organisms exchange information or resources. Dishonesty can thus be expected to have damaging effects on social coherence if agents cannot trust the information or goods they receive. However, a distinction is often drawn between prosocial lies ('white' lies) and anti... | [
"The Social World and Its Interactions",
"The Human Mind and Its Complexity",
"Computer Science and Informatics"
] |
10.1163/19606028-bja10009 | The preservation of proto-Japanese tone class 2.5 in the Izumo region explained | In 1981, Okumura Mitsuo reported that the dialect of Izumo Taisha in western Japan had preserved remnants of the separate tone class 2. 5, which until then had only been found in dialects in central Japan. His discovery proved that this tone class had formed part of proto-Japanese, but the phonetic realization in Izumo... | [
"The Human Mind and Its Complexity"
] |
W2921623269 | Experimental and Computational Studies of Unimolecular 1,1-HX (X = F, Cl) Elimination Reactions of C<sub>2</sub>D<sub>5</sub>CHFCl: Role of Carbene:HF and HCl Adducts in the Exit Channel of RCHFCl and RCHCl<sub>2</sub> Reactions | The gas-phase unimolecular reactions of C2D5CHFCl molecules with 94 kcal mol-1 of vibrational energy have been studied by the chemical-activation experimental technique and by electronic-structure computations. Products from the reaction of C2D5CHFCl molecules, formed by the recombination of C2D5 and CHFCl radicals in ... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
215451 | Microrna isoforms for molecular interception of cervical cancer using self-samples | With 13,000 deaths each year in the EU, cervical cancer (CC) is one of the deadliest cancers worldwide. This is unnecessary, since CC is well detectable and treatable at early stages. For this reason, most EU countries have screening programs in place. These screening programs have had (varying) success in reducing CC ... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1038/s41375-018-0350-3 | Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome | RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q- syndrome, but mouse models of each gene deficiency recapitulate only a subset of the composite clinical features. We analyzed the combinatorial effect of haploinsufficiency for Rps14, Csnk1a1, and miRNA-145, using mice with genetically engineered, condit... | [
"Immunity, Infection and Immunotherapy",
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1073/pnas.1514076113 | An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response | Inhibitors of the HIV aspartyl protease [HIV protease inhibitors (HIV-PIs)] are the cornerstone of treatment for HIV. Beyond their well-defined antiretroviral activity, these drugs have additional effects that modulate cell viability and homeostasis. However, little is known about the virus-independent pathways engaged... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Immunity, Infection and Immunotherapy"
] |
3738810 | The developing communicator: pragmatics, sense conventions and non-literal uses of language | Children are born communicators. A growing body of developmental evidence suggests that the cognitive abilities enabling the expression and comprehension of communicative intentions – so-called pragmatic abilities – which underlie language use and understanding, develop early. However, a puzzling feature of pragmatic d... | [
"The Human Mind and Its Complexity",
"Texts and Concepts"
] |
10.1083/jcb.201704119 | Structure–function insights into direct lipid transfer between membranes by Mmm1–Mdm12 of ERMES | The endoplasmic reticulum (ER)–mitochondrial encounter structure (ERMES) physically links the membranes of the ER and mitochondria in yeast. Although the ER and mitochondria cooperate to synthesize glycerophospholipids, whether ERMES directly facilitates the lipid exchange between the two organelles remains controversi... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W2744250313 | Using Government Resettlement Projects as a Sustainable Adaptation Strategy for Climate Change | Given that increasing migration has been addressed as a major consequence of climate change, a growing number of scholars suggest that the planned relocation of people or Government Resettlement Projects (GRPs) should be included in climate change adaptation. This paper reviews the status of climate change and environm... | [
"Earth System Science",
"Human Mobility, Environment, and Space",
"The Social World and Its Interactions"
] |
interreg_3721 | TUDESLOVE II | This Decentralized Tourism project between Italy and Slovenia is the natural development of projects “TUDESLOVE” and “CULTUCADSES” (Culture in the North – Cadses area) funded under Community Initiative Programme INTERREG II. Specifically, it serves to implement and enhance the tourist-cultural itineraries set up in the... | [
"Human Mobility, Environment, and Space",
"Studies of Cultures and Arts"
] |
10.1088/0957-4484/21/36/365705 | Nanocompression Of Individual Multilayered Polyhedral Nanoparticles | Inorganic layered materials can form hollow multilayered polyhedral nanoparticles. The size of these multi-wall quasi-spherical structures varies from 4 to 300 nm. These materials exhibit excellent tribological and wear-resisting properties. Measuring and evaluating the stiffness of individual nanoparticle is a non-tri... | [
"Condensed Matter Physics",
"Materials Engineering"
] |
EP 2009063970 W | DRIVE APPARATUS FOR MOVING A SLIDING DOOR BY MOTOR AND METHOD FOR ACTUATING THE DRIVE APPARATUS | A drive apparatus (1) for moving - in particular for opening and/or closing - moving furniture parts by motor, said apparatus being designed, in particular, for opening and/or closing a sliding door (2) on an item (3) of furniture having at least one or more sliding doors (2), and said apparatus having the following: a... | [
"Products and Processes Engineering",
"Systems and Communication Engineering"
] |
W2890486612 | The rise of inter-firm agreements in the Japanese video game industry | The purpose of this paper is to examine inter-firm agreements between small firms and a large well-established firm, focusing on agreements involving complementary products. The well-documented emergence of the Japanese home video game industry is sourced for stylised facts to contribute to literature about the nature ... | [
"Individuals, Markets and Organisations"
] |
10.1109/TMI.2015.2480061 | Wide Angle Tissue Doppler Imaging At High Frame Rate Using Multi Line Transmit Beamforming An Experimental Validation In Vivo | Color tissue Doppler imaging (TDI) is a well-established methodology to assess local myocardial motion/deformation. Typically, a frame rate of $\sim 200~{\rm Hz}$ can be achieved by imaging a narrow sector ( $\sim 30^{\circ}$ , covering one cardiac wall) at moderate line density, using a dedicated pulse sequence and mu... | [
"Systems and Communication Engineering",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W2332797094 | Review of Existing QSAR/QSPR Models Developed for Properties Used in Hazardous Chemicals Classification System | The development of a globally harmonized system (GHS) on an international level requires various countries to classify chemicals according to hazardous properties using similar categories. The classification criteria include physical, toxic (health), and environmental properties. The GHS is also being included in the U... | [
"Physical and Analytical Chemical Sciences",
"Computer Science and Informatics"
] |
US 2007/0086958 W | SYSTEM AND METHOD FOR LOW-DELAY, INTERACTIVE COMMUNICATION USING MULTIPLE TCP CONNECTIONS AND SCALABLE CODING | Systems and methods for communication of scaleable-coded audiovisual signals over multiple TCP/IP connections are provided. The sender schedules and prioritizes transmission of individual scalable-coded data packets over the plurality of TCP connections according to their relative importance in the scalable coding stru... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1038/nri.2016.55 | C-type lectin receptors in the control of T helper cell differentiation | Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as ot... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.3390/rs11060681 | A comparative review of manifold learning techniques for hyperspectral and polarimetric sar image fusion | In remote sensing, hyperspectral and polarimetric synthetic aperture radar (PolSAR) images are the two most versatile data sources for a wide range of applications such as land use land cover classification. However, the fusion of these two data sources receive less attention than many other, because of their scarce da... | [
"Computer Science and Informatics",
"Earth System Science"
] |
10.1261/rna.038794.113 | S6:S18 ribosomal protein complex interacts with a structural motif present in its own mRNA | Prokaryotic ribosomal protein genes are typically grouped within highly conserved operons. In many cases, one or more of the encoded proteins not only bind to a specific site in the ribosomal RNA, but also to a motif localized within their own mRNA, and thereby regulate expression of the operon. In this study, we compu... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Computer Science and Informatics"
] |
10.1007/s10329-016-0542-2 | Vertical bipedal locomotion in wild bearded capuchin monkeys (Sapajus libidinosus) | When carrying objects, nonhuman primates often show bipedal locomotion. Studies of primate bipedality, however, in both nature and captivity, have concentrated on locomotion on horizontal substrates, either terrestrially or arboreally. No observational or experimental study seems to have looked at non-horizontal bipeda... | [
"Environmental Biology, Ecology and Evolution",
"Integrative Biology: from Genes and Genomes to Systems"
] |
184495 | Synthetic viability of homologous recombination-deficient cancers | Although various effective anti-cancer drug treatments have become available over the last decades, drug resistance remains the major cause of death of cancer patients. Striking examples are patients with tumors that are defective in DNA repair by homologous recombination (HR). Despite initial responses to cancer thera... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
W2296244854 | Correlation functions of three-dimensional Yang-Mills theory from Dyson-Schwinger equations | The two- and three-point functions and the four-gluon vertex of three-dimensional Yang-Mills theory are calculated from their Dyson-Schwinger equations and the 3PI effective action. Within a self-contained truncation various effects of truncating Dyson-Schwinger equations are studied. Estimates for the errors induced b... | [
"Fundamental Constituents of Matter",
"Mathematics"
] |
W1829809973 | Survey of Hypoglycemia in Elderly People With Type 2 Diabetes Mellitus in Japan | The number of elderly type 2 diabetes mellitus (T2DM) patients in Japan is increasing continuously. Hypoglycemia is a significant issue in their treatment. However, the actual situation and related details of their hypoglycemia remain unclear. In order to elucidate them, the Japan Physicians Association conducted a lar... | [
"Physiology in Health, Disease and Ageing",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1016/j.procir.2018.08.275 | Stability of turning process with tool subjected to compression | This study investigates how the stability of the turning process changes when the tangential component of the cutting force is also taken into account as a compressive force acting on the cutting tool. The tool is modelled by a cantilever beam; the mathematical model is based on the Euler-Bernoulli beam theory. The eff... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
W565412643 | Palace of Culture: Andrew Carnegie's Museums and Library in Pittsburgh | Andrew Carnegie is remembered as one of the world s great philanthropists. As a boy, he witnessed the benevolence of a businessman who lent his personal book collection to laborer s apprentices. That early experience inspired Carnegie to create the Free to the People Carnegie Library in 1895 in Pittsburgh, Pennsylvania... | [
"Studies of Cultures and Arts",
"The Study of the Human Past"
] |
interreg_2262 | Development and promotion of Mediterranean Sustainable Adventure Tourism | The Mediterranean region is one of the world’s leading tourist destinations. Facing growing competition and deterioration of the political and security situation, the destination has demonstrated symptoms of a slowdown, which makes the recovery of the sector an economic priority. This downturn may also present an oppor... | [
"Human Mobility, Environment, and Space",
"Individuals, Markets and Organisations",
"Environmental Biology, Ecology and Evolution"
] |
W2188351152 | PENGARUH PERBEDAAN TEMPORER ANTARA LABA AKUNTANSI DENGAN LABA KENA PAJAK TERHADAP PERTUMBUHAN LABA KE DEPAN (Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia 2010-2012) | This study aims to examine the effect of temporary differences between accounting income and taxes income for future earning growth. The independent variable of this study is deductible temporary differences and taxable temporary differences, the dependent variable is future earning growth, and the control variable are... | [
"Individuals, Markets and Organisations"
] |
277588 | Advancing the Green Chemistry of Singlet Oxygen and Applying it to Synthetic Challenges | Novel synthetic methods are vital to the work of a host of key chemical disciplines; from new materials and nanotechnology to pharmaceuticals, practitioners constantly need cleaner, greener, milder and more efficient ways to synthesize their chosen targets. In this proposal, we seek to develop, and then apply to some v... | [
"Synthetic Chemistry and Materials",
"Physical and Analytical Chemical Sciences",
"Products and Processes Engineering"
] |
10.1038/ncomms8118 | Photoswitchable fatty acids enable optical control of TRPV1 | Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare ... | [
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1007/s10455-012-9341-1 | Interlacing inequalities for eigenvalues of discrete Laplace operators | The term "interlacing" refers to systematic inequalities between the sequences of eigenvalues of two operators defined on objects related by a specific operation. In particular, knowledge of the spectrum of one of the objects then implies eigenvalue bounds for the other one. In this paper, we therefore develop topologi... | [
"Mathematics"
] |
interreg_1262 | EXPERIENCE, DISCOVER & VALORISE HIDDEN TREASURE TOWNS AND SITES OF THE ADRIATIC AREA | In Italy and Croatia it is easy to identify many small towns with very relevant historical, cultural and natural assets, but visited by a little number of tourists, lower than the potentiality of the local natural and cultural resources. The main goal of this project is to reduce this gap between resources and tourists... | [
"Human Mobility, Environment, and Space",
"Studies of Cultures and Arts"
] |
10.1021/acs.jpcc.9b00945 | Tuning the Structure of Pt Nanoparticles through Support Interactions: An in Situ Polarized X-ray Absorption Study Coupled with Atomistic Simulations | Interactions of nanoparticles (NPs) with their environment may have a pronounced effect on their structure and shape as well as on their functionality in applications such as catalysis. It is therefore crucial to disentangle the particle-adsorbate and particle-support interaction effects on the particle shape, its loca... | [
"Condensed Matter Physics",
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials"
] |
10.1111/nyas.12148 | Vision: Are models of object recognition catching up with the brain? | Object recognition has been a central yet elusive goal of computational vision. For many years, computer performance seemed highly deficient and unable to emulate the basic capabilities of the human recognition system. Over the past decade or so, computer scientists and neuroscientists have developed algorithms and sys... | [
"Neuroscience and Disorders of the Nervous System",
"Computer Science and Informatics"
] |
10.1001/jamaneurol.2014.1358 | Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-Amyloid 42: A cross-validation study against amyloid positron emission tomography | Results The agreement between Aβ classification with CSF Aβ42 and 18F-flutemetamol positron emission tomography was very high (? = 0. 85). Of all the cases, 92%were classified identically using an Aβ42 cutoff of 647 pg/mL or less. Cerebrospinal fluid Aβ42 predicted abnormal cortical Aβ deposition accurately (odds ratio... | [
"Neuroscience and Disorders of the Nervous System",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1109/ECC.2016.7810430 | Hammerstein System Identification Using Ls Svm And Steady State Time Response | In this paper a new system identification approach for Hammerstein systems is proposed. A straightforward estimation of the nonlinear block through the use of LS-SVM is done by making use of the behavior of Hammerstein systems in steady state. Using the estimated nonlinear block, the intermediate variable is calculated... | [
"Systems and Communication Engineering",
"Computer Science and Informatics"
] |
10.1117/12.2265431 | Polarization Insensitive Ge Rich Silicon Germanium Waveguides For Optical Interconnects On Silicon | We propose germanium-rich silicon germanium waveguides as a basic building block for polarization insensitive circuitry on silicon. In this work a detailed study of SiGe waveguides geometries is performed to find optimal parameters to simultaneously obtain low polarization sensitivity and single mode operation at λ=1. ... | [
"Condensed Matter Physics",
"Systems and Communication Engineering"
] |
339787 | Towards the NEXT generation of bb0nu experimets | Neutrinoless double beta decay is a hypothetical, very slow radioactive process whose observation would establish unambiguously that massive neutrinos are Majorana particles --- that is to say, identical to their antiparticles ---, which implies that a new physics scale beyond the Standard Model must exist. Furthermore... | [
"Fundamental Constituents of Matter",
"Systems and Communication Engineering"
] |
221522 | Synthetic dcs for a t cell production platform | Cancer immunotherapy and adoptive transfer of genetically manipulated T cells in particular has shown promising results for the treatment of cancer. Central in cancer immunotherapy is the activation of tumour-specific T cells. However, the wide-spread clinical use of T cell therapies remains limited due to costly, time... | [
"Immunity, Infection and Immunotherapy",
"Biotechnology and Biosystems Engineering",
"Materials Engineering"
] |
10.1145/2600057.2602903 | Cryptographically Blinded Games Leveraging Players Limitations For Equilibria And Profit | In this work we apply methods from cryptography to enable mutually distrusting players to implement broad classes of mediated equilibria of strategic games without trusted mediation. Our implementation uses a pre-play 'cheap talk' phase, consisting of non- binding communication between players prior to play in the orig... | [
"Computer Science and Informatics",
"Individuals, Markets and Organisations"
] |
10.1109/TMI.2016.2589760 | Extended Modality Propagation Image Synthesis Of Pathological Cases | This paper describes a novel generative model for the synthesis of multi-modal medical images of pathological cases based on a single label map. Our model builds upon i) a generative model commonly used for label fusion and multi-atlas patch-based segmentation of healthy anatomical structures, ii) the Modality Propagat... | [
"Computer Science and Informatics",
"Prevention, Diagnosis and Treatment of Human Diseases"
] |
10.1172/JCI74692 | Identification And Validation Of N Acetyltransferase 2 As An Insulin Sensitivity Gene | Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis remains largely unknown. The GENEticS of Insulin Sensitivity consortium conducte... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Integrative Biology: from Genes and Genomes to Systems",
"Physiology in Health, Disease and Ageing"
] |
10.1016/j.healthplace.2015.08.010 | Geographical Text Analysis: A new approach to understanding nineteenth-century mortality | This paper uses a combination of Geographic Information Systems (GIS) and corpus linguistic analysis to extract and analyse disease related keywords from the Registrar-General's Decennial Supplements. Combined with known mortality figures, this provides, for the first time, a spatial picture of the relationship between... | [
"Human Mobility, Environment, and Space",
"The Study of the Human Past",
"Computer Science and Informatics"
] |
10.3390/plants5010014 | Beyond the canon: Within-plant and population-level heterogeneity in jasmonate signaling engaged by plant-insect interactions | Plants have evolved sophisticated communication and defense systems with which they interact with insects. Jasmonates are synthesized from the oxylipin pathway and act as pivotal cellular orchestrators of many of the metabolic and physiological processes that mediate these interactions. Many of these jasmonate-dependen... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Environmental Biology, Ecology and Evolution",
"Integrative Biology: from Genes and Genomes to Systems"
] |
W1044702324 | Design of regeneration recycling water networks by means of concentration potentials and a linear programming method | Abstract Regeneration reuse/recycling of industrial wastewater can effectively reduce freshwater consumption and wastewater discharge amount. A new method is presented in this article to design regeneration recycling water networks with multiple contaminants. The concentration potentials and linear programming approach... | [
"Products and Processes Engineering",
"Physical and Analytical Chemical Sciences",
"Computer Science and Informatics"
] |
10.1371/journal.pone.0067521 | A New Method for the Analysis of Soft Tissues with Data Acquired under Field Conditions | Analyzing soft-tissue structures is particularly challenging due to the lack of homologous landmarks that can be reliably identified across time and specimens. This is particularly true when data are to be collected under field conditions. Here, we present a method that combines photogrammetric techniques and geometric... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Computer Science and Informatics",
"Environmental Biology, Ecology and Evolution"
] |
US 2014/0030070 W | METHODS AND DEVICES FOR SAMPLE COLLECTION AND SAMPLE SEPARATION | Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed compo... | [
"Products and Processes Engineering",
"Materials Engineering"
] |
W1911805982 | Protein gels and emulsions from mixtures of Cape hake and pea proteins | Portioning of frozen fish generates by-products such as fish 'sawdust' and cut-offs which can be further processed into protein concentrates and isolates. The objective of the present work was to produce gels and emulsions using recovered Cape hake protein powder (HPP). In previous works, the structures of the gels pro... | [
"Materials Engineering",
"Physical and Analytical Chemical Sciences",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
223596 | Functional exploration of the contributions of brainstem-motor thalamic pathways to motor execution and learning | Motor learning is a fundamental process enabling an organism to improve movement efficiency during a motor task. It is supported by motor cortex, which organizes movements into complex sequences. Yet, how this structure is informed of planned and generated actions is poorly understood. Anatomically, motor cortex is hig... | [
"Neuroscience and Disorders of the Nervous System",
"Integrative Biology: from Genes and Genomes to Systems"
] |
W2171163162 | LA SUCESIÓN ENTRE LOS INCAS | One of the most controversial subjects with regard to the Andean pre Hispanic Organization is the one referring to succession of command. The Incas are not an exception on this matter, and since the sixteenth century the query has been raised and more than one theory has been devised. The subject has not been alien to ... | [
"The Study of the Human Past",
"Studies of Cultures and Arts"
] |
10.1161/HYPERTENSIONAHA.118.11382 | Computed Tomography And Adrenal Venous Sampling In The Diagnosis Of Unilateral Primary Aldosteronism | Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and is usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical and biochemical postsurgical outcomes of patients with unilater... | [
"Prevention, Diagnosis and Treatment of Human Diseases",
"Physiology in Health, Disease and Ageing"
] |
W2288489881 | Measurement and analysis of 3G WCDMA network performance case study: Yogyakarta Indonesia | Yogyakarta is an education and tourism city. The quality of internet services is needed to support the education quality and tourist services. These services are supported by 3G WCDMA technology. This paper will discuss the need of Information Technology (IT) for education and tourism sector, and also assesment of the ... | [
"Systems and Communication Engineering",
"Products and Processes Engineering"
] |
10.1146/annurev-ecolsys-110512-135825 | Geographic mode of speciation and genomic divergence | Understanding speciation requires determining how inherent barriers to gene flow (reproductive isolation, RI) evolve between populations. The field of population genomics attempts to address this question by characterizing genome-wide patterns of divergence between taxa, often utilizing next-generation sequencing. Here... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Environmental Biology, Ecology and Evolution"
] |
10.1371/journal.pgen.1004813 | Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease | Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation are poorly characterised. Here we present the first genome-wide st... | [
"Integrative Biology: from Genes and Genomes to Systems",
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Physiology in Health, Disease and Ageing"
] |
10.1039/C5CC00693G | Tetrabenzocircumpyrene A Nanographene Fragment With An Embedded Peripentacene Core | A new disc-shaped highly symmetric C54H20 nanographene fragment, tetrabenzocircumpyrene, has been synthesized and characterized by scanning tunnelling microscopy, demonstrating the potential of this technique for identifying highly insoluble graphenic molecules. | [
"Physical and Analytical Chemical Sciences",
"Condensed Matter Physics"
] |
170274 | Identification and characterization of cis-regulatory moduledysfunction in rett syndrome with roq-wach | Precise regulation of gene expression is achieved through the coordinated action of genomic cis-regulatory modules (CRMs). The identification of CRMs has long been a goal of functional genomics as CRM dysregulation can have devastating consequences for health and development such as autism. For example, mutations in th... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Neuroscience and Disorders of the Nervous System",
"Integrative Biology: from Genes and Genomes to Systems"
] |
10.1016/j.tplants.2009.09.010 | When more is better: multigene engineering in plants | The genomics revolution has taught us that a great deal of information can be derived from studying many genes or proteins at the same time. We are beginning to see this approach blossoming in applied research. Instead of attempting to generate useful transgenic plants by introducing single genes, we now see an increas... | [
"Molecules of Life: Biological Mechanisms, Structures and Functions",
"Biotechnology and Biosystems Engineering"
] |
10.1016/j.molcel.2017.05.014 | Histone Mutants Separate R Loop Formation from Genome Instability Induction | R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R loops but do not cause instability. R loops containing single-stranded DNA (ssDNA), versus RNA-DNA hy... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
10.1142/S0218202515400059 | Sparse Stabilization And Control Of Alignment Models | Starting with the seminal papers of Reynolds (1987), Vicsek et al. (1995), Cucker–Smale (2007), there has been a lot of recent works on models of self-alignment and consensus dynamics. Self-organization has so far been the main driving concept of this research direction. However, the evidence that in practice self-orga... | [
"Mathematics",
"Systems and Communication Engineering"
] |
W2129875228 | Modelling and control of proton exchange membrane fuel cell | Proton exchange membrane fuel cell (PEMFC) has been considered as one of the most promising energy sources due to its many desirable properties, including high power density, low operating temperature and fast start-up. However, significant technical challenges exist before PEMFC can be commercialized. Among them, the ... | [
"Systems and Communication Engineering",
"Products and Processes Engineering",
"Computer Science and Informatics"
] |
758769 | Resonant Electromagnetic Microscopy: Imaging Cells Electronically | Microfluidics technology has been quite successful in fabricating small, low-cost devices with excellent analyte handling capabilities. However, the main detection paradigm in microfluidics has still been optical microscopy — which is a bulky and expensive technique. A chip-scale detection scheme that can provide multi... | [
"Systems and Communication Engineering",
"Condensed Matter Physics",
"Cell Biology, Development, Stem Cells and Regeneration"
] |
10.1073/pnas.1317643111 | Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection | The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 12 (NLRP12) plays a protective role in intestinal inflammation and carcinogenesis, but the physiological function of this NLR during microbial infection is largely unexplored. Salmonella enterica serovar Typhimurium (S. ty... | [
"Immunity, Infection and Immunotherapy",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
W2315628567 | Determination of environmental radioactivity (238U, 232Th and 40K) and indoor natural background radiation level in Chennai city (Tamilnadu State), India | An extensive study on the determination of the natural radioactivity ((238)U, (232)Th and (40)K) levels in soil samples of Chennai city, India has been undertaken and the results of the same are compared with the levels reported in other Indian cities as well as other parts of the world. The radioactivity content in th... | [
"Earth System Science",
"Physical and Analytical Chemical Sciences"
] |
10.1007/s00220-014-2031-z | Mean-Field Evolution of Fermionic Systems | The mean field limit for systems of many fermions is naturally coupled with a semiclassical limit. This makes the analysis of the mean field regime much more involved, compared with bosonic systems. In this paper, we study the dynamics of initial data close to a Slater determinant, whose reduced one-particle density is... | [
"Fundamental Constituents of Matter",
"Mathematics"
] |
interreg_3481 | Saastal Valle Anzasca Bike | The project provides an answer to the tourist vocation of the area by promoting a sustainable enhancement of the environmental heritage. It has specific objectives: the development and promotion of the tourism potential linked to the cycle-hiking in the cross-border area surrounding Monte Rosa; the completion of a rout... | [
"Human Mobility, Environment, and Space",
"Products and Processes Engineering"
] |
10.1017/CBO9780511819049.012 | Selecting Models Of Evolution | THEORY Models of evolution and phylogeny reconstruction Phylogenetic reconstruction is a problem of statistical inference. Since statistical inferences cannot be drawn in the absence of probabilities, the use of a model of nucleotide substitution or amino acid replacement – a model of evolution – becomes indispensable ... | [
"Mathematics",
"Environmental Biology, Ecology and Evolution"
] |
W2511593010 | The Xitieshan volcanic sediment-hosted massive sulfide deposit, North Qaidam, China: Geology, structural deformation and geochronology | Abstract The Xitieshan deposit (~ 64 Mt at 4.86% Zn, 4.16% Pb, 58 g/t Ag, and 0.68 g/t Au) is hosted by the Middle to Late Ordovician Tanjianshan Group of the North Qaidam tectonic metallogenic belt, NW China. This belt is characterized by island arc volcanic, ultra-high pressure (UHP) metamorphic and ophiolitic rocks.... | [
"Earth System Science"
] |
W2593009560 | Missions involvement and interfaith relations: Forming pathways of commonality | The reality of an ever-accelerating globalization, accompanied by an expanding religious pluralism, presents significant challenges to many long-enduring concepts of doing missions. This article will focus on identifying some of those challenges and offering some possible options for ongoing missions involvement. Parti... | [
"The Social World and Its Interactions",
"Studies of Cultures and Arts"
] |
10.1007/s00216-019-01674-9 | Immobilization of proteolytic enzymes on replica-molded thiol-ene micropillar reactors via thiol-gold interaction | We introduce rapid replica molding of ordered, high-aspect-ratio, thiol-ene micropillar arrays for implementation of microfluidic immobilized enzyme reactors (IMERs). By exploiting the abundance of free surface thiols of off-stoichiometric thiol-ene compositions, we were able to functionalize the native thiol-ene micro... | [
"Physical and Analytical Chemical Sciences",
"Synthetic Chemistry and Materials",
"Materials Engineering"
] |
803506 | The Rise and Fall of Populism and Extremism | In the recent years in advanced democracies there has been a wave of electoral successes of populist politicians supporting extreme messages. Is populism caused by negative economic shocks? If so, what are the mechanisms? What explains heterogeneity in responses to such shocks? In this project, I will test empirically ... | [
"Individuals, Markets and Organisations",
"Institutions, Governance and Legal Systems",
"The Social World and Its Interactions"
] |
10.1016/j.celrep.2016.10.007 | The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes | Mammalian oocytes are stored in the ovary, where they are arrested in prophase for prolonged periods. The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood. Here, we identify and characterize an essential pathway for the resumption of meiosis that relies on... | [
"Cell Biology, Development, Stem Cells and Regeneration",
"Molecules of Life: Biological Mechanisms, Structures and Functions"
] |
279980 | Fundamental Physics at the Low Background Frontier | The nature of dark matter is one of the fundamental questions in physics today. Direct signals for dark matter have remained elusive, indicating that multi-tonne scale detectors are needed to measure large numbers of dark matter interactions, while current efforts are at the 100 kg scale. The foremost challenge is di... | [
"Fundamental Constituents of Matter",
"Universe Sciences"
] |
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