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gen_a2beb335b2c19415945779006122cb2b | Historic Ice Core | Arcadia Fundation | Harvard University (Department of History) | 360G-ArcadiaFund-4190 | To document and interpret historical environmental data captured in an ice core from a glacier in the Alps. | Other / Strategic | 6project_grants_public |
gen_51ffb2a79c3b97e5808eea7706c86b40 | Historical Ice Core Project | Arcadia Fundation | Harvard University (Department of History) | 360G-ArcadiaFund-3862 | To continue extraction and interpretation of data from an ice core documenting European climate in the last 3,500 years. | Other / Strategic | 6project_grants_public |
gen_84532a96025a151c41c506b0909f1db0 | Mapping Africa's endangered sites and monuments | Arcadia Fundation | University of Cambridge McDonald Institute for Archaeological Research | 360G-ArcadiaFund-4179 | To undertake large-scale documentation of heritage sites in Sub-Saharan Africa and to make the results available online through an open-access database. | Heritage sites / Strategic | 6project_grants_public |
gen_9037569aabc408670819602dc5fb921a | Endangered Archaeology of the Middle East and North Africa | Arcadia Fundation | University of Oxford (School of Archaeology) | 360G-ArcadiaFund-4178 | To document archaeological heritage in the Middle East and North Africa using satellite imagery. | Heritage sites / Strategic | 6project_grants_public |
gen_28cd5e03a4bb3cae7f982846aca64cca | Developing non-destructive methods to read texts in mummy cartonnages | Arcadia Fundation | University College London | 360G-ArcadiaFund-3733 | To assess the feasibility of nondestructive digital imaging technology to read texts on papyri in mummy cartonnages. All data, findings and methodologies will be freely available online for further research. | Other / Strategic | 6project_grants_public |
gen_d254647a09e082ad3fff64a958dced42 | Mosfell Archaeological Project | Arcadia Fundation | Vikingaminjar ehf | 360G-ArcadiaFund-3119 | To excavate and research a Viking-age archaeological site in western Iceland, in partnership with UCLA and the Institute for Viking and North Atlantic Studies. | Heritage sites / Strategic | 6project_grants_public |
gen_c04fe5ad85f80fa4cc536239a3b2653c | Noves estratègies per la identificació i caracterització funcional de marcadors genètics pronòstics en les síndromes mielodispàsiques/leucèmies agudes mieloblàstiques hereditàries de la infància | La Marató de TV3 | Fundació per a la Recerca i la Docència Hospital Sant Joan de Déu - FSJD | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_ed09a2d7b889b6b7ebb6d216f95ffa5c | Transcripció espurial neuronal i desregulació d'estimuladors en l'etiologia de la discapacitat intel·lectual | La Marató de TV3 | Institut de Neurociències - Universitat Miguel Hernández, Alacant | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_bc7dd453c1f52688d7f8a6caef6c825f | iGenCO: anàlisi genòmica exhaustiva i anàlisi cross-òmica per a malalties minoritàries no diagnosticades en una plataforma col·laborativa amigable | La Marató de TV3 | Fundació Privada Centre de Regulació Genòmica - Centre Nacional d'Anàlisi Genòmica CRG | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_24697349f8b239bac8779c79164823ab | Anàlisi preclínica de nous tractaments combinats per a l'atròfia muscular espinal: efectes sobre la supervivència de la moroneurona, la integritat sinàptica i la preservació del múscul esquelètic | La Marató de TV3 | Institut de Recerca Biomèdica de Lleida Fundació Dr. Pifarré - IRBLL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_d50aab7938c04a00721ad68ec39b48e0 | Genòmica avançada i lipidòmica per a la identificació de noves causes genètiques de trastorns de moviment hereditaris | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica Hospital Universitari de Bellvitge - IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_3ff7115203df53d8fa39b9a8d0fc7cf8 | Recerca centrada en el pacient: estudi de les necessitats dels pacients, fenotipació clínica i patogènesi molecular en la Neurofibromatosi tipus 2 | La Marató de TV3 | Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol - IIGTP | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_78cb1cf2c7d6dc925f7a0fef7b780a63 | Predisposició germinal a la síndrome de poliposi serrada: caracterització funcional de gens candidats mitjançant CRISPR/CAS i organoides | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_88d28d5312822a31f280d8ae38065215 | Registre PSP: estudi de cohort clínics, recerca de biomarcadors i programa d'educació sanitària | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clìnic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_ca3954694330d0a3e7ee6306fb525012 | Avaluació de la teràpia cel·lular mitjançant cèl·lules RPE corregides genèticament en mamífers inferiors i superiors per al tractament de les distròfies hereditàries de la retina | La Marató de TV3 | Fundació Centre d'Investigació Príncep Felip, València - CIPF | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_273b3526c051fc57cb7499a85e9939b0 | Desenvolupament de tractaments personalitzats en malalties genètiques rares causants de parkinsonisme pediàtric | La Marató de TV3 | Fundació per a la Recerca i la Docència Hospital Sant Joan de Déu - FSJD | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_23a1ebbe1a5b48198d16a092724ca799 | Gliotransmissors i receptors de cannabinoides en l'origen dels dèficits cognitius i de plasticitat sinàptica en la malaltia de Huntington | La Marató de TV3 | Universitat de Barcelona - Facultat de Medicina i Ciències de la Salut UB | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_e970d2f4a3853f9ade61576486c865b2 | Fenilcetonuria: de la infantesa als adults a través del connectoma cerebral, canvis cardiovasculars, característiques metabòliques i de la microbiota intestinal | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_2332d23bbb8ef63941008a54d126aa11 | Eliminar cèl·lules senescents per controlar les comorbiditats de la síndrome de Cushing | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_57ed88e3460d8d17e2f7ecc951ce51c6 | CoALeS: Optimitzant els resultats a llarg termini de nens amb coartació de l'aorta mitjançant l'aprenentatge automàtic integrant dades des del fetus fins a la infància | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_cd13f4c0f76706b5327dfba1447f9651 | Rol de l'Apolipoproteïna A-Ib en la síndrome nefròtica idiopàtica | La Marató de TV3 | Fundació Hospital Universitari Vall d'Hebron Institut de Recerca - VHIR | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_88b047ed434aa48cb3e051c75545320c | Alteracions bioquímiques i del neurodesenvolupament en la malaltia de Lesch-Nyhan | La Marató de TV3 | Universitat Autònoma de Barcelona - Institut de Neurociències UAB | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_2ae490f3e0d8d008c2ef8a8b197568fb | Vinculació de defectes cel·lulars amb manifestacions clíniques a la síndrome de Cohe | La Marató de TV3 | Fundació Institut de Recerca Biomèdica de Barcelona - IRBB | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_c5ad294e3c9e525a198175fc5d1a33de | Desoxiribonucleòsids com a teràpia per als trastorns de la replicació de l'ADN mitocondrial: investigació dels mecanismes terapèutics i ampliació del tractament a les mutacions en POLG i altres gens | La Marató de TV3 | Fundació Hospital Universitari Vall d'Hebron Institut de Recerca - VHIR | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_dd181764041697c1847a204c99f87dbb | La senescència cel·lular, un nou objectiu per combatre i millorar la distròfia muscular de Duchenne | La Marató de TV3 | Universitat Pompeu Fabra - Facultat de Ciències de la Salut i de la Vida UPF | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_56da632247102543f6db1c792fc6cf64 | ArmTracker: Un sistema portable per avaluar la funció motora de les extremitats superiors durant la vida diària per a pacients amb distròfia muscular de Duchenne i atròfia muscular espinal | La Marató de TV3 | Fundació per a la Recerca i la Docència Hospital Sant Joan de Déu - FSJD | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_2a1351d508232816089aa626b6a0f35e | Noves aplicacions terapèutiques a l'acondroplàsia | La Marató de TV3 | Institut de Neurociències d'Alacant - CSIC | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_0fe9a1b96faaea357edaf6e0020fdfbc | Estratègies terapèutiques per a la cistinúria | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica Hospital Universitari de Bellvitge - IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_fe4629edda25bf14463826678909efbe | Anàlisi del sistema de complement en la preeclàmpsia greu i la síndrome de Hellp com a diana terapèutica | La Marató de TV3 | Fundació Recerca Clínic BCN – Institut d’Investigacions Biomèdiques August Pi i Sunyer | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_1b9c9efd175958b432c7076bca4ea7f2 | Impulsa la integració de cèl·lules trasplantades per regenerar retines amb Retinitis Pigmentària | La Marató de TV3 | Fundació Privada Centre de Regulació Genòmica - CRG | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_c390f6babf37d6cbd2839d9f36e62632 | Caracterització dels esdeveniments moleculars inicials de la carcinogènesi associada a la síndrome de Deficiència Reparadora Constitucional (CMMRD) per millorar el seguiment i la prevenció del càncer | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica de Bellvitge - Institut Català d'Oncologia ICO IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_c8717fcadd4774609732c2701a365967 | Cap a la millora de l'assistència clínica i la cura de la linfangioleiomiomatosi: estudi integrat de biomarcadors i teràpies | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica de Bellvitge - Institut Català d'Oncologia ICO IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_5925e086069db4d1407a102e737a9015 | Modulació de la senyalització retrògrada mitocondrial com a tractament de la síndrome de Leigh | La Marató de TV3 | Universitat Autònoma de Barcelona - Facultat de Medicina UAB | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_86fd243d84483acbd886ef13ddb3e97a | Alteracions de la tiroide en pacients amb un defecte heretat de la maquinària de biogènesi del miRNA | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica Hospital Universitari de Bellvitge - IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_663206c605c9db460705e820a865a814 | La malaltia de Lafora: paper de la glia en la producció de glicogen aberrant i neuroinflamació | La Marató de TV3 | Institut de Biomedicina de València, CSIC | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_a055bbdcc9661c7288e98d0eb9766128 | Lipodistròfia i sarcopènia en la síndrome de progèria Hutchinson-Gilford: mecanismes i paper en la progressió de la malaltia | La Marató de TV3 | Universitat Pompeu Fabra - Facultat de Ciències de la Salut i de la Vida UPF | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_dc9d90492ebd8cda59894e15c5db91a4 | Noves teràpies dirigides contra subpoblacions de cèl·lules fibroadipogèniques implicades en la degeneració muscular | La Marató de TV3 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau - IRHSCSP | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_e4fed8952425105f1be70b7827e9879b | Disfunció de la barrera hematoencefàlica i modulació de l'estrès oxidatiu en malformacions arteriovenoses cerebrals: Un estudi translacional del dany secundari posterior a la resecció quirúrgica | La Marató de TV3 | Consorci Institut d'Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic - IDIBAPS | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_6dadb4457b4fb6a8864c1306d8b03a75 | Ús de la intel·ligència artificial i la biologia de sistemes per a la diagnosi i l'avaluació de risc personalitzat per a les malalties renals hereditàries, centrat en la síndrome d'Alport | La Marató de TV3 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau - IRHSCSP | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_9db9700fca5fafb456ed4746b26b550f | Desxifrant els mecanismes de l'autoimmunitat de cèl·lules B específiques de PLA2R a la nefropatia membranosa primària (PMN) (BCELL-MEM) | La Marató de TV3 | Fundació Institut d'Investigació Biomèdica Hospital Universitari de Bellvitge - IDIBELL | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_eb0fbb3b81d574762d922aff73a767f4 | Inhibició d'ACVR1-PI3K a Fibrodisplàsia ossificant progressiva: noves teràpies per a l'ossificació heterotòpica | La Marató de TV3 | Universitat de Barcelona - Facultat de Medicina i Ciències de la Salut UB | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_76512b0e2edf95a19d3f841af6311e00 | Relació de la infertilitat genètica masculina amb les regions d'unió entre toroides de l'espermatozoide | La Marató de TV3 | Universitat de Girona - Departament de Ciències Mèdiques UDG | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_72417b4ba9fdd32683688094fc261aae | Mecanismes aritmogènics específics del genotip en la síndrome d'Andersen-Tawil | La Marató de TV3 | Fundación para la Investigación del Hospital Universitario La Fe - FIHFE | Not available | La Marató 2019 Malalties minoritàries | 6project_grants_public | |
gen_2bf029061f90f61fd5109956a0489cb1 | A randomised, observer-blind, non-inferiority trial to evaluate alternative human papillomavirus vaccination schedules in young females in West Africa | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_00757 | The trial will investigate the potential future utility of alternative HPV vaccination schedules in West Africa. The schedules aim to reduce the financial and logistical burden of HPV vaccine rollout and to provide new opportunities to optimise coverage. The following questions will be addressed: 1. Does the administra... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_8d97ad5ca923cbdf97e6e728e3a19b5d | A non-inferiority trial to assess the safety and immunogenicity of yellow fever vaccine dose sparing strategies for campaign and programmatic use | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_00759 | A phase 3, randomized, observer-blind non-inferiority trial will be undertaken to assess the safety and immunogenicity of fractional doses of the yellow fever vaccine when administered to 9-12 month olds in The Gambia. In 2016, the worst epidemic of yellow fever in 30 years occurred in Central Africa on a background of... | 3.4 Vaccines / Research Grant | 6project_grants_public |
gen_85f17067dd28f985da8ab86f1ed276b4 | SUPPLEMENTARY FUNDING OFFER FOR THE MRC UNIT, THE GAMBIA AT LSHTM (resource to support a clinical trial of Hydroxychloroquine and Azithromycin, studies on the transmission and antibody dynamics to SARS-CoV-2 infection, and to further support | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_00851 | This £4.4m award provides resource to support a clinical trial of Hydroxychloroquine and Azithromycin, studies on the transmission and antibody dynamics to SARS-CoV-2 infection, and to further support surveillance activities funded by BMGF. Including PaTS-COVID CLINICAL TRIAL – led by Professor Beate Kampmann with an e... | 2.2 Factors relating to physical environment / P&Cs | 6project_grants_public |
gen_ec150e5ae6f02f91d95e69dbf3004761 | Enhancing the Unit Support of Uganda’s Efforts to Contain COVID-19 - part 2 | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_00854 | Following the initial rapid successes in supporting the national diagnostic capacity and to characterise the viruses, the Unit now recognizes its ability and responsibility to continue working as a close partner and reliable ally of the Government in ramping up the response to prevent the further spread of this deadly ... | 2.6 Resources and infrastructure (aetiology) / P&Cs | 6project_grants_public |
gen_a193486af86348a1286693130ae7f4fb | Community surveillance for SARS-CoV-2 and COVID-19 in the general and in high risk populations in Uganda and assessment of the wider impact of infection and of pandemic mitigation. | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_00855 | In collaboration with MoH, we will undertake rigorous community SARS-CoV2/COVID-19 surveillance in high-risk and general populations, to identify infected individuals with and without symptoms. This would provide a robust foundation for answering critical scientific questions relating to the pandemic, including on tran... | 2.1 Biological and endogenous factors / P&Cs | 6project_grants_public |
gen_5c848934184f9fe38c34ba0042d3855a | Excess mortality during the COVID-19 pandemic in The Gambia: a denominator based analysis within the HDSSs | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_00861 | The COVID-19 pandemic is causing an unprecedented global burden of mortality. Mathematical models predicted that most West African countries, one of the poorest regions in the world, would exceed 100,000 COVID-19 cases by June 2020. As a result, most countries reacted pragmatically closing borders after the first few c... | 2.4 Surveillance and distribution / P&Cs | 6project_grants_public |
gen_627b7f0839b8fa1e3d89099c280a44e6 | Population differences in vaccine response (POPVAC)-2: the impact of environmental exposures and selected interventions on waning of vaccine-induced immune responses | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_00901 | We propose that parasite infections contribute substantially to population differences in vaccine response; and that their effects are mediate We will test this hypothesis through four linked objectives among Ugandan adolescents. An immunisation programme comprising relevant live and inert vaccines will be given over o... | 3.4 Vaccines / P&Cs | 6project_grants_public |
gen_b614a0b9e47755a15c752f3d8bef3ecb | Evaluating the implementation of the Peer Educator Intervention for improving adolescent health in India's National Adolescent Health Programme | Medical Research Council | Public Health Foundation of India (PHFI) | HRCS22_00921 | India is home to 243 million adolescents, yet they remain an understudied population in India with lack of data on the health indicators for this age group and current levels of knowledge on adolescent health issues and effective approaches on reaching marginalized adolescents. In 2014, the Ministry of Health and Famil... | 8.4 Research design and methodologies (health services) / Research Grant | 6project_grants_public |
gen_7bcd0ff5f84840c02583f9d7b525f059 | A randomised controlled trial (RCT) to evaluate a scalable active case finding primary care-based intervention for tuberculosis using a point-of-care | Medical Research Council | University of Cape Town | HRCS22_00923 | A startling statistic is that more than 40% of TB cases in endemic countries are "missing" (~4.2 million cases globally remain undiagnosed or unreported)! Most of these undiagnosed cases, which continue to transmit disease, are concentrated in the peri-urban 'slums' and 'shanty towns' of large African cities. Without a... | 2.5 Research design and methodologies (aetiology) / P&Cs | 6project_grants_public |
gen_18ae9effe140ccabece4c4174c5756cf | Two decades of primary health care expansion in Latin America: evaluation and forecasting study for health-related SDGs | Medical Research Council | Federal University of Bahia (UFBA) | HRCS22_00924 | A strong Primary Health Care(PHC) is essential for achieving Universal Health Coverage(UHC) and should be an integral part of and coordinate multi-sectoral actions addressing economic and social determinants of health, acting synergistically with social interventions such as cash transfer programmes(CCT) and social pen... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_91b732bf910d7647ee8ecdb4f7c445d1 | The risk of a chronic clinical condition following a previous hospitalisation by a psychiatric disorder: a linkage nationwide study in Brazil | Medical Research Council | Fiocruz (Oswaldo Cruz Foundation) | HRCS22_00928 | This project will analyse electronic data routinely collected within the Brazilian Public Health System (SUS). It involves enriching this type of data by linking them to other Brazilian governmental databases destined to national social protection programmes, which have important socio-economic variables of the individ... | 2.1 Biological and endogenous factors / P&Cs | 6project_grants_public |
gen_7b55d04f512318b25e23a3c8846f52b1 | The Khayelitsha Comorbidity Cohort: Establishing a multimorbidity cohort with integrated clinical, genomic and epidemiological data in South Africa. | Medical Research Council | University of Cape Town | HRCS22_00931 | There is high multimorbidity in South Africa, consisting both infectious and non-communicable diseases. Elucidating diagnostic, therapeutic and prognostic genetic drivers of morbidities can help tailor preventative and therapeutic patient care at both population and individual levels, and requires research into associa... | 4.1 Discovery and preclinical testing of markers and technologies / P&Cs | 6project_grants_public |
gen_eb9b1ecaad9361f9c491f612bf1bc0bb | Exploring treatment burden and capacity for self care among patients with HIV/NCD multimorbidity in South Africa to inform interventions (EXTRA) | Medical Research Council | University of Cape Town | HRCS22_00932 | In Sub-Saharan Africa the rising burden of non-communicable diseases (NCDs) against a background of chronic infectious disease epidemics, most notably HIV, is giving rise to patterns of multimorbidy that are occurring in people of working age, with implications for productivity and social stability. Chronic care for pa... | 7.1 Individual care needs / P&Cs | 6project_grants_public |
gen_810a22d5b07954b690f943dbd1a85ae0 | Developing a Digital Health-enabled Intervention to tackle Multimorbidity in Primary care in India | Medical Research Council | Centre for Chronic Disease Control | HRCS22_00936 | More than a quarter of adult patients attending primary care facilities in India have multimorbidity. However, national health programmes are disease-centric, including the ongoing National Programme for Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS), which caters to large population groups in primary ca... | 8.2 Health and welfare economics / P&Cs | 6project_grants_public |
gen_6784b3f85bb352fcededea9a93f951fc | Self-management approaches for individuals with multiple chronic health conditions in rural South Africa | Medical Research Council | University of the Witwatersrand | HRCS22_00938 | South Africans are experiencing a complex, protracted health transition characterised by ongoing burdens from epidemic infectious diseases, particularly HIV/AIDS, rapidly increasing morbidity and mortality from chronic diseases such as heart diseases, stroke, cancer and metabolic disorders and ill-prepared healthcare s... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / P&Cs | 6project_grants_public |
gen_26dae5ea3087e2c13354a6d978362f86 | 2018 - DTA - Gambia (at LSH&TM) | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01015 | In developing societies characterised by complete absence of vital registration systems, the continuous demographic surveillance (DSS) approach to data collection provides the best opportunity to generate the quantitative and qualitative evidence of disease burden needed for the formulation and/or adjustment of health ... | HRCS Research Uncodeable / Studentship | 6project_grants_public |
gen_5221aaeb96a8e0631bf1eb98dab77d07 | Pathogen Genomics, Phenotype and Immunity (PGPI) & Basic Sciences Programme | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_01304 | We propose to monitor the HIV epidemic by characterising the circulating HIV-1 subtypes especially in recent infections and use full length genome sequencing to understand better the increasing recombinant viruses using better bioinformatics tools. We will use molecular in combination with social-epidemiological and mo... | 1.1 Normal biological development and functioning / Unit | 6project_grants_public |
gen_a346b078bc8447e355fc08f394c7f98b | Cancer Epidemiology | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_01305 | We will build on our work showing that the malignant and non-malignant consequences of oncogenic infections (including HIV) are a major cause of morbidity and mortality in Uganda and that lifestyle risk-factors such as tobacco are currently relatively less important in this setting. We will i) examine the transmission ... | 2.1 Biological and endogenous factors / Unit | 6project_grants_public |
gen_5258662cd625c5edeaef01b3b601f0a9 | HIV Epidemiology and Prevention Programme | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_01306 | This Programme has two broad areas within which there are specific projects. a) Prevent acquisition of new infections in general and in key populations: i) assess knowledge and preferences for biomedical HIV prevention interventions and adherence to oral PrEP and determine best recruitment and retention strategies for ... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Unit | 6project_grants_public |
gen_0a054175559d216008aed7a04fb9a7d5 | Social Aspects of Health across the Life Course Programme | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_01307 | The aim of the programme is to further our understanding of the social aspects of health and wellbeing for specified individuals and populations to inform the design, implementation and evaluation of interventions, as well as contribute to policy development. We will work primarily across the HIV and Non-Communicable D... | 2.3 Psychological, social and economic factors / Unit | 6project_grants_public |
gen_751d569f08353ba050a0647369486076 | Immunomodulation and Vaccines | Medical Research Council | MRC/UVRI and LSHTM Research Unit Uganda | HRCS22_01308 | Our goal is to understand the impact of infection exposure on human immunological programming and health. Our overarching hypothesis is that chronic and cumulative infection exposure influences immunological mechanisms through active processes (during current infection), lasting epigenetic modifications, and genetic se... | 2.1 Biological and endogenous factors / Unit | 6project_grants_public |
gen_52a5b102a24708a9cddba7e2411d41b9 | Thematic Support - Disease Control and Elimination | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01342 | The theme answers scientific questions related to the control and elimination of infectious diseases by designing large epidemiological studies and clinical trials (i.e., individually and cluster randomized). These projects target, beyond clinical cases, asymptomatic infections as these are key for maintaining transmis... | 2.2 Factors relating to physical environment / Unit | 6project_grants_public |
gen_1c1f10369e15ef6c883222fc86d56fee | Thematic Support - Vaccines and Immunity | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01344 | The Vaccines & Immunity (V&I) Theme aims to contribute to the evidence‐based development and delivery of vaccines through integration of laboratory science with clinical trials and longitudinal cohort studies, including for tuberculosis. Using cutting‐edge immunological methods and bioinformatic approaches, we investig... | 3.4 Vaccines / Unit | 6project_grants_public |
gen_3e61604abee26d4995a2066e84b82471 | Thematic Support - Nutrition Planetary Health | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01345 | Emerging nations such as The Gambia suffer a double burden of malnutrition: rates of undernutrition in mothers and young children are gradually diminishing but remain a major threat to health and well-being; meanwhile rates of overweight and obesity are escalating rapidly with the attendant risks of diabetes and hypert... | 2.1 Biological and endogenous factors / Unit | 6project_grants_public |
gen_5d6cc9261b9cda9d26f4a30e61c0c880 | Surveillance & Epidemics Preparedness | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01347 | Surveillance & Epidemics Preparedness | HRCS Research Uncodeable / Unit | 6project_grants_public |
gen_169e22356dc4b88fd40cec2691d1c7be | A randomized controlled trial of influenza vaccine to prevent adverse vascular events. | Medical Research Council | McMaster University | HRCS22_01393 | The goal of this study is to assess whether inactivated influenza vaccine can reduce adverse vascular events in high risk participants. We will address the question by randomizing patients at high risk for adverse vascular events to either annual inactivated influenza vaccine or to placebo over three influenza seasons.... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_5ab0b550e0335ea1d235ab2fdfad6605 | Designing and evaluating provider results-based financing for tuberculosis care in Georgia: understanding costs, mechanisms of effect and impact | Medical Research Council | Curatio International Foundation | HRCS22_01486 | The study will first inform how the problem is conceptualised and the intervention is designed in collaboration with the policy makers at national level. Once piloting is started, the research will seek to answer the following research questions: (1) What is the impact of provider-focused Results Based Financing (RBF) ... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_477397e7c8c420cc5e7032dc13932cb8 | Examining the level and variation in the efficiency of county health systems in Kenya, and how it can be improved | Medical Research Council | KEMRI Wellcome Trust Research Programme | HRCS22_01633 | This research aims to measure the level of efficiency of the 47 county health systems in Kenya, and to examine its determinants. It also aims to examine the potential for efficiency gains and how this can in turn result in increased fiscal space for the Kenyan health sector. Further, the research aims to test the appli... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_d6012a09ab0cfb33779eeb031a1e7faf | Infection, inflammation and hepcidin-mediated iron deficiency anaemia in African children | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_01722 | The 2016 Global Burden of Disease analysis estimates that 1.225 billion people suffer from iron deficiency anaemia (IDA) and it is the fourth largest contributor to years lived with disability (YLD) globally. The burden is concentrated in sub-Saharan Africa and South Asia. Iron is crucial for neural development and ear... | 2.1 Biological and endogenous factors / Research Grant | 6project_grants_public |
gen_67a03f2d3ada67b73f7de4f7d46706a0 | Phase III, Multicentre, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy of Probiotic Supplementation for Prevention of Neona | Medical Research Council | Indian Council for Medical Res (ICMR) | HRCS22_01846 | Neonatal infections (pneumonia, septicaemia, meningitis) are responsible for more than a quarter of the 1 million neonatal deaths every year in India(1). Low Birth Weight (LBW) is a very important indirect cause of death in neonates, accounting for 40% to 80% of neonatal deaths (2-3). Management of neonatal sepsis with... | 3.3 Nutrition and chemoprevention / Research Grant | 6project_grants_public |
gen_7a537b0ab3b7752ee4525651213e3ff3 | High Dose Oral Rifampicin to Improve Survival from Adult TB Meningitis - (HARVEST) Trial | Medical Research Council | Infectious Diseases Institute (IDI) | HRCS22_01848 | Tuberculous meningitis, the most severe form of TB, results in death or neurological disability in >50% of those affected, and mortality is 2-3 fold greater in HIV-infected patients. Rifampicin, a primary TB medication, only achieves in cerebrospinal fluid (CSF) 10-20% of the levels observed in blood. We propose a phas... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_38515e5f983819c08693833c505a0c33 | Integrating Refugees into National Health Systems: Enhancing Equity and Strengthening Sustainable Health Services for All. | Medical Research Council | American University of Beirut | HRCS22_01945 | This study will employ a comparative case study approach focusing on three countries currently hosting large numbers of refugees: Lebanon (1.1m), Jordan (655,624), and Uganda (940,800). We plan to focus on Syrian refugees in Lebanon and Jordan, and South Sudanese refugees in Uganda. Our research will seek to: (i) under... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_231b7e92191f4ab00b09286a127ea22f | Adolescents' Resilience and Treatment nEeds for Mental health in Indian Slums (ARTEMIS) | Medical Research Council | The George Inst for Global Health India | HRCS22_02027 | The proposed trial will be a hybrid effectiveness-implementation cluster randomised trial with wards/blocks (only urban slums will be included) being the unit of allocation. The trial will implement a mobile-technology enabled mental health services delivery model for adolescents living in slums in two Indian cities - ... | 6.6 Psychological and behavioural / Research Grant | 6project_grants_public |
gen_5b435c65b1c8580ae6b51a0e381e3cf8 | Crowdsourcing with adolescents in Senegal to address social norms limiting their access to sexual and reproductive health services | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02034 | The overall aim of this research project is to co-develop an intervention with adolescents aged 15 to 19 in order to address the social norms that limit their access to available sexual and reproductive health (SRH) services. The proposed research will take place in two regions of Senegal, one peri-urban area in Dakar ... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_d7e769cf811f27ab80003e2763b868a1 | Project HASHTAG: Health Action in Schools for a Thriving Adolescent Generation | Medical Research Council | Stellenbosch University | HRCS22_02037 | Background. Adolescents suffer a high burden of disease, mostly injuries and mental disorders. Universal school interventions offer opportunities to address early symptoms and risk factors. We conducted a systematic review and meta-analysis of such interventions, finding that most are 'single-issue' interventions from ... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_10a932e9e6a618e716ff107d92257b7f | Prevention of Addiction and Mental Ill Health in Adolescents in Georgia (PAMAd) | Medical Research Council | Curatio International Foundation | HRCS22_02050 | The study will first inform how the PAMAd service (package of interventions) is designed in collaboration with potential service beneficiaries (CA and their family members), service providers, main stakeholders and policy makers at national level and also generate evidence on effectiveness of CA targeted service (clini... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_302b609aa9fa8f72caa8fd286ec6784b | A Novel High Intensity Short Interval Dance Intervention for Non Communicable Disease(NCD) Prevention in Asian Indian Adolescent Girls-THANDAV | Medical Research Council | Madras Diabetes Research Foundation | HRCS22_02201 | The proposal aims to study the effect of the THANDAV intervention on physical activity, fitness levels,body weight and fat % in Asian Indian adolescent girls using digital technology. High intensity interval training (HIIT) is a form of cardiovascular exercise plan alternating short periods of intense aerobic exercise ... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_ea5cc4d087289dbef89e168db4e2f55f | BRIGHT-SAM: BRaIn development, Growth and HealTh in children with Severe Acute Malnutrition | Medical Research Council | National Institute for Medical Research | HRCS22_02203 | The use of ready-to-use therapeutic foods (RUTF) for community-based management of children with severe acute malnutrition (SAM) is well-established and saves lives. However, current RUTF formulations result in a low ratio of n3/n6 essential fatty acids (EFAs) and other data show that low levels of the n3 EFA, docosahe... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_ba9307636ff18b8eadc0086dabc9c349 | Development and application of Novel, Integrated Tools for monitoring and managing Catchments | European Commission | Ajuntament de Manlleu; AZIENDA GARDESANA SERVIZI SPA; Brunel University London | CORDIS-689341 | INTCATCH will instigate a paradigm shift in the monitoring and management of surface water quality that is fit for global waters in the period 2020-2050. INTCATCH will do this by developing efficient, user-friendly water monitoring strategies and systems based on innovative technologies that will provide real time data... | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_a0a5d8eb64de7917cb1d2f4aab919d29 | Latent rheumatic heart disease in West Africa: a pilot multi-country study | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02207 | This trial development grant (TDG) aims at generating epidemiological and feasibility data data to inform the design of a multicentric trial in West Africa to test the efficacy of penicillin to prevent the progression of latent RHD towards overt clinical disease. This is urgently needed to formulate long awaited guidel... | 4.2 Evaluation of markers and technologies / Research Grant | 6project_grants_public |
gen_a1d385019124dfb077ba0df187b90886 | Enhancing brain development by early iron supplementation of African infants: An enabling pilot study | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02208 | Growth and organisation of the human brain is maximally active in late fetal life and early infancy. Breast milk contains very little iron and babies born to iron deficient mothers lack the full endowment of hepatic iron that usually subsidises the needs for growth and brain development in early infancy. We have recent... | 4.1 Discovery and preclinical testing of markers and technologies / Research Grant | 6project_grants_public |
gen_083eac5a74b0e6bfb598c735024c8b1e | MICA: The third, Intensive care bundle with blood pressure reduction in acute cerebral haemorrhage (INTERACT3) trial | Medical Research Council | George Institute for Global Health | HRCS22_02216 | INTERACT3 is an international, multicentre, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial (Phase III-IV). The objective is to determine the effectiveness of a goal-directed care bundle of active management involving intensive BP lowering, glycaemic control, early treatment of pyrexia, and ... | 4.1 Discovery and preclinical testing of markers and technologies / Research Grant | 6project_grants_public |
gen_02d755937309fe0aa9ab4c6e6679d88a | A feasibility and pilot trial of enteral probiotic administration in preterm infants admitted to a neonatal unit in Nigeria | Medical Research Council | University of Ibadan | HRCS22_02219 | Our proposal is based on a fixed effects meta-analysis of 23 RCTs of preterm infants in 10 LMICs (n=4,783; Deshpande 2017). Probiotics reduced all cause mortality (RR 0.73 [95% CI 0.59 to 0.90]; P=0.003), necrotising enterocolitis (RR 0.46 [0.34 to 0.61]; P<0.00001), late-onset sepsis (RR 0.80 [0.71 to 0.91]; P=0.0009)... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_a06c36db975df5a6d6dea4884511fd99 | Concentration and fragmentation: analysing the implications of the structure of Georgia's private healthcare market for quality and accessibility | Medical Research Council | Curatio International Foundation | HRCS22_02313 | To inform decisionmakers on how to engage effectively with the private sector, better evidence is needed of how healthcare markets are structured, the risks of different market structures for patients and for the health system as a whole. This evidence can help design health system policies to (i) shape the market to a... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_0bf4b85a5197144f7d0e838e27c6cc26 | Understanding male engagement in child health and nutrition in urban informal settlements: A formative participatory exploration | Medical Research Council | KEMRI Wellcome Trust Research Programme | HRCS22_02326 | Improving child health requires primary prevention, quality health services and community action. Whilst there is recognition that the health system encompasses both the suppliers of policy, services, and interventions, and the communities and households intended to benefit from them; in health systems research the foc... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_81a0a381f6ec9b4b97c27b89eff7cc00 | Identifying the health systems changes necessary to sustain and scale up the integration of mental health services into primary care in Lagos, Nigeria | Medical Research Council | Lagos State Univ Coll of Med LAUSCOM | HRCS22_02328 | STATEMENT OF THE PROBLEM: There are policy and ethical implications of developing effective heath programmes without sustainability and scale-up. This feasibility study aims to identify the strategies to facilitate the health system changes necessary to sustain and scale up mental health services in primary care in Lag... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_5d4c4c5a7b7e619832e8031f838701a4 | A systems approach to examining health sector responses to cholera epidemics in Kenya | Medical Research Council | Strathmore University | HRCS22_02329 | Technical Summary Kenya has experienced an increased disease burden due to cholera outbreaks characterized by continuous transmission in the refugee camp settings of Garissa and Turkana, and sporadic transmission in cities such as Nairobi and Mombasa. However, while inquiry has been made regarding how the health sector... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_616b48f87f61ad34e5d97364ab410e72 | Examining effects of decision-making space and its practices on health systems performance in Tanzania | Medical Research Council | University of Dar es Salaam | HRCS22_02342 | Many low and middle income countries (LMICs), including Tanzania, have been implementing decentralisation since 1990s as a process to strengthen health systems and its performance through improved efficiency, quality of services and a means of promoting democracy and accountability. While decentralisation is widely pra... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_eea8f20f4ca1030a45c8a293ee297574 | Understanding the consequences for quality and efficiency of expanding services through the private sector in South Africa | Medical Research Council | University of the Witwatersrand | HRCS22_02343 | The private sector provides a large proportion of health services in many low- and middle-income countries (LMICs), particularly for primary health care (PHC), even for the poor. But the role of the private sector in expanding universal health coverage (UHC) in LMICs is contentious. Supporters of private care provision... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_f94b42d390f12bd3822aa39bba3485ff | An inter-disciplinary approach to understanding and intervening on contextual factors that shape HIV-risk for young women and men in South Africa | Medical Research Council | South African Medical Research Council | HRCS22_02420 | Background: South Africa remains the epicentre globally of the HIV-epidemic, driven by harsh contexts of gender inequalities, poverty and community violence. Understandings of how these impact on the syndemic of HIV-acquisition risk, intimate partner violence (IPV), poor mental health and substance misuse, for young wo... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_66ee2592e45bfbdb91ec99c697599873 | Nutrition and the epigenome: early environmental factors influencing human developmental programming | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02477 | A seasonal 'experiment of nature' in rural Gambia has revealed the presence of DNA methylation (DNAm) hotspots sensitive to periconceptional environment. These are enriched for metastable epialleles, endogenous retroviruses and parent-of-origin-specific methylation (PofOm) suggesting establishment in the early embryo. ... | 2.4 Surveillance and distribution / Research Grant | 6project_grants_public |
gen_d6e5a101ac85554bcb081496bea9584c | Understanding and measuring pregnancy-related anxiety in low- and middle-income contexts: A pilot study in northern Ghana | Medical Research Council | University for Development Studies | HRCS22_02499 | Women's anxiety during pregnancy is widespread and has been associated with poor mental and physical health outcomes for both mothers and their children. One type of anxiety which seems to be particularly problematic is anxiety about the pregnancy itself. We know little about pregnancy-related anxiety in LMICs and ther... | 2.3 Psychological, social and economic factors / Research Grant | 6project_grants_public |
gen_fd679e6b38a0acdead398406441f2e81 | Oral Vitamin D supplementation as a safe, affordable treatment for profound vitamin D deficiency in pregnancy | Medical Research Council | CBCI Society for Medical Education | HRCS22_02500 | We aim to address to the extent supplementation with 2000 IU/day vitamin D3 corrects deficiency in pregnant women in India, which has not previously been tested. We propose this is linked to lack of awareness amongst stakeholders of the benefits of offering higher vitamin D doses than current Indian RDA (<500 IU/day). ... | 6.1 Pharmaceuticals / Research Grant | 6project_grants_public |
gen_91d501031e530c6fbcc381b3f41f57a8 | Capacity building for a Centre of Design, Innovation and Translational Excellence (CITE) for clinical trials of healthcare technologies in SS Africa | Medical Research Council | Makerere University | HRCS22_02505 | Great strides have been taken to reduce global maternal and neonatal mortality. However, due to numerous factors such as limited access to resources including funding, healthcare providers among others, means that maternal and neonatal mortality have remained stubbornly high in sub-Saharan Africa. Advances in technolog... | 3.5 Resources and infrastructure (prevention) / Research Grant | 6project_grants_public |
gen_1d8b4b877270e7d308fb7e8cf8ccd086 | Reducing infection risks in maternity and neonatal wards through improved environmental hygiene: an exploratory study in The Gambia. | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02506 | The aim of this research is to explore the links between environmental hygiene and infection risks in maternity and neonatal units in two hospitals in the Gambia. We will use the learning derived from this preliminary work to convene a network of researchers to build the case for a future African trial of this interven... | 3.2 Interventions to alter physical and biological environmental risks / Research Grant | 6project_grants_public |
gen_a625673d2919a2b7decd897415f181fc | Adolescent mental, sexual and reproductive health and wellbeing policy, program and primary care implementation priorities in West Africa | Medical Research Council | Ghana College of Physicians and Surgeons | HRCS22_02510 | The principal research question of this study is: "what and why are adolescent wellbeing policy and program priorities in countries in West Africa, what mental, sexual and reproductive health services are available at primary health care level for adolescent health and wellbeing; are they proven effective, what and why... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_2355cf34df175e087a29e54d99db74fa | If I Were Thabo: Optimisation and feasibility trial of a gender transformative sexual and reproductive health intervention in South Africa and Lesotho | Medical Research Council | Stellenbosch University | HRCS22_02512 | A key social determinant of sexual and reproductive health-related (SRH) morbidity and mortality in Southern Africa is unequal gender norms. The importance of working with men as well as women using Gender-Transformative (GT) approaches, in order to reduce gender inequality and improve SRH outcomes for all is well-reco... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
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