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gen_0be1c7ae5c3aa742530fb52e2d396b03 | Contribution of fatty acid metabolism to the advanced and metastatic phenotype of pancreatic cancer | Worldwide Cancer Research | Instituto de Investigación Sanitaria Aragón | HRCS22_13690 | Pancreatic Ductal Adenocarcinoma (PDAC) is an extremely lethal disease due to the current lack of effective therapies and extreme malignancy of the tumours once diagnosed. We have recently shown that PDAC is hierarchically organised with Cancer Stem Cells (CSCs) constituting a major source for disease progression, incl... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_635bd8cd7972480f4c0ea93ac63abafb | Tools to Highlight Impact and Aid Curation of Scholarly Outputs | Wellcome Trust | American Society for Cell Biology | HRCS22_13707 | The proliferation of scholarly content and implementation of transparent peer review are creating challenges for readers and evaluators to assess research significance and review outcomes, and for journals to curate field-specific content. We propose controlled experiments in which we test the utility of badges and imp... | No Research Activity assigned | 6project_grants_public |
gen_2fd8b1bedcd8851386a3bf43a9a4b34a | Filling in the gaps during a crisis of care: social and political constructions of lay care work during the HIV/AIDs epidemic and the Covid-19 pandemic in South Africa. | Wellcome Trust | University of the Western Cape | HRCS22_13713 | The project aims to explore the various social and political constructions of lay care work during the Covid-19 pandemic and the early stages of the HIV/AIDs epidemic in Cape Town. It will analyse the tensions and possibilities that arise when informal, self-organised and localised care work done by ordinary people int... | No Research Activity assigned | 6project_grants_public |
gen_ee8f01dd9c1ef3bd9097c8ce4b50a15d | PRECISION - supplementary award | Cancer Research UK | University of Texas MD Anderson Cancer Center | HRCS22_13775 | Background Ductal carcinoma in situ (DCIS) now represents 20-25% of all breast neoplasia. This is due to large-scale detection by widely adopted population-based breast cancer screening programs . As a result, thousands of women are confronted with DCIS each year: more than 8,000 in the UK, 2,300 in the Netherlands, an... | 2.6 Resources and infrastructure (aetiology) | 6project_grants_public |
gen_cee277dd4d3fff26bd3c01a14f1b1071 | Social security for children with disabilities in rural South African communities: family caregiver, health worker, civil society, and policy implementer perspectives on access to and the use of the Care Dependency Grant in the Cape Winelands | Wellcome Trust | Stellenbosch University | HRCS22_13786 | In South Africa, state-funded social protection for disabled children has primarily been through the Care Dependency Grant (CDG). The CDG is distributed to the caregivers of these children and provides important financial assistance, but it is under-researched. Little is known about caregivers’ access and utilisation o... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_f550a07b390fe0c9a67f2758d61bf665 | Improving the prediction of endometrial cancer risk using genetics | Worldwide Cancer Research | QIMR Berghofer Medical Research Institute | HRCS22_13825 | Endometrial cancer (cancer of the uterine lining) is the most commonly diagnosed gynaecological cancer in developed countries, including Australia. Its incidence is rapidly increasing due to the ageing population and rising rates of obesity, the strongest known risk factor for endometrial cancer. This is a global probl... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_b7217427976bbf234e2b66a35b98bc13 | Assessment of the impact of mycotoxins on the epigenome and their synergistic role with EBV in endemic Burkitt lymphoma in African children | Children with Cancer UK | International Agency for Research on Cancer | HRCS22_13849 | Chronic exposure to toxins (Mycotoxins) produced by moulds (Fungi) and infection with oncogenic viruses have been shown to increase a person’s chances of developing cancer; for example, the synergy between Aflatoxin B1(AFB1) and Hepatitis B virus infection have been shown to increase the development of Liver cancer 1. ... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_fb0bf5f01ec0788f101a2c66dc7a95a8 | Liraglutide: A phase II, randomized, double-blinded, placebo-controlled trial of Liraglutide in Parkinson’s disease (Extension 1) | Cure Parkinson's | Cedars-Sinai Medical Center | HRCS22_13854 | Extension to MT011. See above. | 6.1 Pharmaceuticals | 6project_grants_public |
gen_cd0d1462819e5d8ae760e511ee9978c2 | Silence, solitude, and serotonin: how hearing loss and social isolation converge to influence serotonergic regulation of the auditory midbrain | Royal National Institute for Deaf People | Indiana University | HRCS22_13910 | The social isolation that often accompanies hearing impairment in older adults co-occurs with other health concerns, including depression, anxiety, and cognitive decline. A contributing factor to these negative outcomes may be dysfunctional communication driven by deficits in auditory processing and perception. We will... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_63a21e7a089e8aa4079861a955044896 | The development of a best-in-class iron chelator to prevent oxidative stress, iron regulated cell death (ferroptosis) and synucleinopathy as a treatment for Parkinson’s Disease, to-gether with the integration of biomarkers of target engagement and efficacy. | Cure Parkinson's | Centre Hospitalier Universitaire de Lille | HRCS22_13946 | Excessive labile iron in the Substantia Nigra pars compacta (SNpc) is a pathognomonic hallmark of PD and leads to increased production of noxious reactive oxygen species. Alpha-synuclein regulates dopamine and iron transport, with PD associated mutations in this protein causing functional disruption of these processes.... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_7a22b8bf23c4f9bddc1d26b78136023e | Enteric Pathogens and Post-discharge Outcomes among Children in sub-Saharan Africa and South Asia (The EPPO-SASA Study) | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_13957 | Enteric pathogens are a major cause of hospitalisation among children and are associated with diarrhoea, enteric dysfunction, dysbiosis, and increased risk of mortality and readmission especially in low- and middle-income countries. When admitted to hospital, treatment failure may occur despite following guidelines. Fu... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_57027a0cb8aef15033ac39477a2a5a07 | RECOVER (Real World Clinical Outcomes with Novel Modulator Therapy Combinations in People with CF) | Cystic Fibrosis Trust | Children's Health Ireland at Crumlin | HRCS22_13961 | Triple combination CFTR modulator therapy (TCMT), has shown promising results on important health outcomes in clinical trials in PWCF and has been approved in the US for use in people>12 years of age with one or more copy of F508del. Approval in Europe is pending, subsequent to which the drug will be provided for use i... | No Research Activity assigned | 6project_grants_public |
gen_cfca34f1f6fde4ffb411423bce3e59d1 | Developing native strains of insect-killing Metarhizium spp. fungi to prevent malaria transmission in Burkina Faso | Wellcome Trust | Institut de Recherche en Sciences de la Santé | HRCS22_13969 | Despite efforts developing entomopathogenic fungi as biocontrol agents against disease vectors, expectations have not been met due to their relatively poor efficacy compared to cheaper chemical insecticides. The vast majority of mosquito control studies have focused on a single fungal isolate. However, the recent disco... | 3.2 Interventions to alter physical and biological environmental risks | 6project_grants_public |
gen_567f6468ad03f1e0e112c724db15378a | A digital dashboard to support institutions implementing open science: Establishing a core set of open science metrics to track | Wellcome Trust | University of Ottawa | HRCS22_13974 | The completion of the proposed research program will result in two key outputs: 1) a core outcome set of open science (OS) metrics relevant to, and developed by, the biomedical community; and 2) a usable flexible, tailorable, and automated tool, developed using user-centred design best practices, that reports on these ... | No Research Activity assigned | 6project_grants_public |
gen_cb46733854f3ce314377df6c2c11a4c3 | Accelerating Drug Discovery with Symbolic-Numerics in SciML | Wellcome Trust | Boston University | HRCS22_14003 | Pharmaceutical companies understand the need for modeling stochasticity, by which we can improve the reliability and effectiveness of drugs across the whole population. Our 2020 review in Trends in Pharmacological Sciences, one of the highest impact journals in pharmacology, argued that deterministic models that ignore... | No Research Activity assigned | 6project_grants_public |
gen_d6179e7774b38ede89a677d01cdb127a | Data-driven drug discovery for A-T – interrogation of dysfunctional pathways at single-cell resolution in cerebellar organoids | Action for A-T | QIMR Berghofer Medical Research Institute | HRCS22_14090 | Using a data-driven approach, informed by single-cell sequencing of a large cohort of ATM_x0002_deficient cerebellar brain organoids - the hypothsis is that computational prediction of drugs will allow selective, positive modulation of aberrant pathways and behaviour in the team's in vitro model of the A-T cerebellum. ... | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_a4d8dad4026b2da9b5bc8fe060a0d402 | Innovative methods for gene therapy in A-T | Action for A-T | University of Granada | HRCS22_14091 | This project will be looking at Innovative methods for the potential of delivering gene therapy in A-T | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_0a6ad8a2d5b65b37a12332585eff8573 | Discovering new aminoglycosides to alleviate inner ear toxicity | Royal National Institute for Deaf People | Stanford University | HRCS22_14099 | Aminoglycosides are a class of widely used, broad spectrum antibiotics that cause hearing impairments in upwards of 20% of treated patients and even higher percentages if repeated treatments are needed or susceptible genetic mutations are present. Although aminoglycoside ototoxicity is a well-documented side-effect, th... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_5e6a6863485bf426599a7c8bfd7e5f86 | Preclinical development of an amelioration therapy for Dentatorubro-Pallidoluysian Atrophy | Ataxia UK | Inserm | HRCS22_14108 | Dentatorubro-Pallidoluysian Atrophy (DRPLA) is a polyglutamine ataxia caused by mutations in the ATROPHIN-1 gene, for which no cure is available. This group have significant experience in models of ataxia and spastic paraplegia with ataxia, and in particular of DRPLA. Following the recent success of antisense oligonucl... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_16ece7846d935d935e76ee5cb7e6b113 | Graphene-based disruptive technologies | European Commission | CENTRO DE INVESTIGACION COOPERATIVADE ENERGIAS ALTERNATIVAS FUNDACION; HORIBA JOBIN YVON S.A.S.; Queen Mary University of London; Sorbonne University; BRETON SPA; University of Augsburg; BRUNO BALDASSARI & FRATELLI SPA | CORDIS-696656 | This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flags... | H2020-EU.1.2. / 1.2 Future and Emerging Technologies (FET) | 6project_grants_public |
gen_e2c9ce9a8c9b6ecfb8ff9188983bb500 | Intimate partner violence against women in low- and middle-income countries: associations with parenting practices and early childhood development. | Wellcome Trust | Associação Brasileira de Saúde Coletiva | HRCS22_14182 | The 2030 Agenda for Sustainable Development highlights the need to prevent and respond to violence against women and girls. It also affirms the need to invest in early childhood care for the promotion of sustainable development in low and middle-income (LMICs). Intimate partner violence (IPV) is one of the most common ... | 2.3 Psychological, social and economic factors | 6project_grants_public |
gen_17dfd315c8331f2682f3cea00fe55c68 | Identifying innate and adaptive immune mechanisms associated with fibrosis in animal models of RDEB | DEBRA | New York Medical College | HRCS22_14225 | We recently demonstrated that TGFβ signaling is activated in RDEB (col7a1-/-) mice as early as a week after birth in the interdigital folds of murine paw skin. At the same time, many critical genes involved in wound healing and fibrosis are significantly upregulated. In preliminary studies, we also observed infiltratio... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_2a72ff736c62a437f0eb41c40b425fe1 | NT3 treatment for brain coding restoration after cochlear synaptopathy | Royal National Institute for Deaf People | University of Michigan Health System | HRCS22_14228 | After noise-exposure that produces TTS, and thus clinically ‘normal’ audiograms, there is nonetheless permanent damage to auditory nerve (AN) - hair-cell synapses. 'Hidden' hearing loss is a potential major health issue, as temporal bone and ABR studies suggest it is common in humans, causing difficulties understanding... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_cbf4e4602db01f5942203dae6a9108c4 | Accelerating the development of lorlatinib to improve cure rates for patients newly diagNOsed ALK-driven high-risk neuroblastoma | Solving Kids' Cancer | Children's Hospital of Philadelphia | HRCS22_14317 | Neuroblastoma, the most common solid tumor malignancy of childhood, encapsulates the full spectrum of cancerheterogeneity. This cancer of the developing peripheral sympathetic nervous system shows widely divergent clinical manifestations, with approximately half of patients exhibiting explosively malignant disease with... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_3d3fc267fa17ce3a91f59793045f055e | Extreme dose rate proton therapy - reducing side effects for brain cancer treatments. | The Brain Tumour Charity | Harvard University | HRCS22_14355 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_7bd2a94c34c915271a4d213bd6be0888 | Establishing the content coverage of available Patient-Reported Outcome (PRO) measures used in neuro-oncology and provide recommendations on the use of these PRO measures: part of the Response Assessment in Neuro-Oncology – Patient Reported Outcome (RANO-PRO) initiative | The Brain Tumour Charity | Leiden University Medical Center | HRCS22_14356 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_d30103d4cf44ae1c9eed9399fda6f394 | fASt and Smart charging solutions for full size URban hEavy Duty applications | European Commission | D'APPOLONIA SPA; RUPPRECHT CONSULT - FORSCHUNG & BERATUNG GMBH; TOFAS – Turk Otomobil Fabrikasi A.S. | CORDIS-769850 | The ASSURED Project proposal addresses the topic GV-08-2017, “Electrified urban commercial vehicles integration with fast charging infrastructure” of the Green Vehicle work programme. A 39-member consortium from 12 different EU Member States will conduct the work. The overall objectives of ASSURED are: - Analysing the... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_3d7a488a964f455d75f7e6a9d1587f75 | Baseline pathology image analyses by deep learning approaches to predict the onset of ESR1 mutations, an exploratory study on samples collected in PADA-1, a UCBG/GINECO phase 3 trial | Worldwide Cancer Research | Institute Curie | HRCS22_14403 | Background Pathology image analysis by deep neural networks has been successfully applied to the detection of numerous mutations (EGFR in NSCLC, BRCA…) already present in tumor cells; these approaches have however never been used to predict whether a resistance mutation will appear later during therapy. Mutations in ES... | 6.1 Pharmaceuticals | 6project_grants_public |
gen_1e5e056f4f6379cf489de6387a835933 | Music, Performing Arts and Artists in the North: The French and Italian Diasporas (1600-1900) | Carlsberg Foundation | Det nationalhistoriske Museum, Frederiskborg Slot and Château de Versailles | CF18-0357 | Not available | Research / Conferences / Award | 6project_grants_public |
gen_9e61d146a48b9c42163a5f163a14e969 | Modelling neuroblastoma - immune cell interactions in a tissue- engineered 3D platform | Neuroblastoma UK | Royal College of Surgeons in Ireland | HRCS22_14420 | Combining 3D printing with cancer research | No Research Activity assigned | 6project_grants_public |
gen_d0acd25723dd0053dcc54bafa035ce92 | Making the invisible visible: In vivo mapping of molecular biomarkers in adult diffuse glioma with CEST MRI | The Brain Tumour Charity | Erasmus MC | HRCS22_14464 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_40ee77306980dbbb51726e2a783c5a95 | Preventing EGFR activation in glioblastomas | The Brain Tumour Charity | Erasmus MC | HRCS22_14481 | Not available | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_4fa88b5eca2f75669a656bd402cddb94 | Extrachromosomal DNA maintenance mechanisms and targeting in glioblastoma | The Brain Tumour Charity | Jackson Laboratory | HRCS22_14497 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_d7178a0d8c26b3c254d87f49f6f90bab | Intra-host genetic diversity of Hepatitis B virus among mother-infant pairs in Botswana | Wellcome Trust | Botswana Harvard AIDS Institute Partnership | HRCS22_14505 | Perinatal transmission is a major route of hepatitis B virus (HBV) transmission in countries with high prevalence rates. 80-90% of HBV infections acquired in the first year of life result in a chronic infection. HBV e antigen positivity and/or HBV viral loads, increases risk of perinatal transmission. HBV vaccination h... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_bf88dd207bf0c426a2c1a2fd38e15ecf | Field evaluation and implementation of rapid diagnostic test for the diagnosis of syphilis in people living with HIV/AIDS. | Wellcome Trust | Centro Internacional de Entrenamiento e Investigaciones Medicas | HRCS22_14508 | Syphilis remains as a public health concern despite effective treatment, especially in people living with HIV/AIDS (PLWHA) since central nervous system and ocular involvement is more frequent. Syphilis screening is an integral component of HIV care, but its coverage is suboptimal and current diagnostic approach in Colo... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_920029dfd4fc8be678c583cbbe050c5f | Investigations into how Anopheles-specific flaviviruses affect arbovirus and Plasmodium transmission | Wellcome Trust | International Centre of Insect Physiology and Ecology | HRCS22_14509 | Despite the vast diversity of arboviruses endemic in East Africa, most research efforts have focused on just a few key viral pathogens. Additionally, estimates of arbovirus diversity in the tropics are likely to be underestimated, especially in Anopheles spp. Many arboviruses are vertically transmitted in mosquitoes, a... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_e710e8d5dfe740f9734b2926f077dc62 | Investigating mechanisms for disseminating the Plasmodium-inhibiting Microsporidia MB symbiont in Anopheles arabiensis | Wellcome Trust | International Centre of Insect Physiology and Ecology | HRCS22_14510 | There has been recent research interest in the prospect of modifying mosquito vectors to make them resistant to Plasmodium infections. One method of modifying mosquitoes involves symbiotic microbes which protect their hosts from infection and are known to persist across multiple generations (transmitted from mother to ... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_318f779c7699239d31d27356a667c86f | Using light to treat fungal infections: photodynamic therapy as an alternative technology to overcome candidiasis | Wellcome Trust | FUNDAÇÃO DE APOIO AO DESENVOLVIMENTO DA UNIVERSIDADE FEDERAL DE PERNAMBUCO (FADE) | HRCS22_14513 | Candidiasis is the 7th most common bloodstream infection in Brazilian hospitalized patients and represents 74% of serious fungal infections in Brazil. Superficial forms of candidiasis can lead to disfiguration, disability, and can potentially become systemic and lethal. There is a limited number of antifungal drugs ava... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_08b39300bd5a990713b885b905ad5e76 | TCR/BCR repertoire sequencing in the conjunctival associated lymphoid tissue from trachoma longitudinal studies | Wellcome Trust | Kilimanjaro Clinical Research Institute | HRCS22_14515 | The primary aim of this study is to use next generation sequencing to investigate the T and B cell receptor repertoire in the conjunctival tissue in those susceptible to repeated ocular infection with Ct and those resistant despite similar exposures.RNA samples selected from archived conjunctival swab samples from a 4-... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_628936e225e8ce1e53b5f817c02a3975 | Can patients understand and use regulatory results? Investigating the influence of risk-rating of health facilities on community engagement and accountability mechanisms in two Kenyan counties. | Wellcome Trust | Strathmore University | HRCS22_14529 | Strategies to address poor implementation of health facility regulation in developing countries have mainly been supply driven, with the emergence of innovative risk-based regulatory frameworks that respond to facility performance. However, there has been less emphasis placed on demand side strategies, with little know... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_b066d104cf26b0ee28e34921439b4a88 | Prioritisation and Risk Evaluation of Medicines in the EnviRonment | European Commission | Eli Lilly and Company Ltd; F. Hoffmann-La Roche AG | CORDIS-875508 | There are around 1900 active pharmaceutical ingredients (APIs) in use, yet the environmental risks of only a small proportion of these has been assessed. This calls for pragmatic science-based approaches for prioritising existing APIs in terms of their environmental risk. Such approaches could also be used pro-actively... | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_933e86855997b917fc5124c8a13c01a0 | Interaction between ionising radiation and genetic susceptibility in the aetiology of childhood acute lymphoblastic leukaemia | Children with Cancer UK | Yale University | HRCS22_14562 | The aetiology of childhood acute lymphoblastic leukaemia (ALL) is largely unknown. Various studies have evaluated the role of ionising radiation and genetic susceptibility, but potential interaction between the two factors has rarely being examined. A major barrier to this type of research is the limited availability o... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_1a14c3e52ee2eb84f53dcf11c2d4618e | Systemic Inflammation and Growth following Acute Illness in Children. | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_14572 | Medical and nutritional management in acutely-ill undernourished children in developing countries aim to support rapid weight gain. However, such children remain at risk of death and poor catch-up growth post-hospital discharge. Little is known about mechanisms regulating childhood growth after acute illness. I hypothe... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_2719cf11c622436d56e731beeaa8381c | Uncovering chromatin aberrations and molecular mechanisms associated with Alternative Lengthening of Telomeres in cancers | Worldwide Cancer Research | Monash University | HRCS22_14594 | Cancer cells gain replicative immortality by activating one of two telomere maintenance pathways. The aberrant ALT (alternative lengthening of telomeres) pathway is found in 15% of cancers. Recent studies have identified chromatin factor ATRX and histone H3.3, which are frequently mutated in ALT cancers to be the key c... | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_3141ea7fea4ccb9825c828fbce540783 | Biomimetic nanocarriers for boosting chemotherapy by restoring breast cancer immunosurveillance | Worldwide Cancer Research | National Research Council | HRCS22_14604 | Triple-negative breast cancer (TNBC) still lacks effective treatment options; thus, innovative targeted therapies are urgently needed to tackle this disease. Emerging evidence suggests that chemotherapeutic drugs, including paclitaxel (PTX), can re-establish immunosurveillance by inducing immunogenic cell death (ICD) a... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_7f78e4335db3742c7f9a2face5afc17c | Improving anti-cancer therapy by stromal remodelling | Worldwide Cancer Research | University of Western Australia | HRCS22_14611 | Despite recent breakthroughs, cancer immunotherapy remains challenging. One of the problems is that anti-tumour T cells - even when activated - do not reach the cancer core in sufficient numbers to be effective. The lead investigator’s laboratory has pioneered the field of tumour blood vessel normalization which signif... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_98c2be89a58e6515e653cec05d073e85 | Checkpoint receptors expressed by dendritic cells- do they play a role in immunotherapies? | Worldwide Cancer Research | Monash University | HRCS22_14612 | The preliminary data of this proposal indicate that PD-1 and other checkpoint inhibitors are upregulated on DC upon activation both in vitro and in vivo. The panel of immune checkpoint proteins expressed by DC is governed by their specific subset. Moreover, human DC subsets show similar upregulation of PD-1 upon activa... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_c9a30fac9104c7e87c823a49a96cf428 | The Development and Optimization of Anti-CLEC12A Targeted Umbilical Cord Blood Derived CAR-NK Cells in Acute Myeloid Leukaemia. | Wellcome Trust | National University of Ireland, Galway | HRCS22_14640 | Acute myeloid leukaemia (AML) is an aggressive form of blood cancer. Current chemotherapy-based treatments cure less than half of all patients with AML. In many cases a relapse occurs which is very difficult to treat effectively. ‘Leukaemia stem cells’ which resist the effects of chemotherapy are an important cause of ... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_26d8d9c5ca6751ccfdad78059825d22b | The Impact of Intensive Medical and Surgical Control of Diabetes on Experimental Rodent Diabetic Kidney Disease. | Wellcome Trust | University College Dublin | HRCS22_14641 | Background: Kidney disease affects 12 in every 100 people, most commonly due to diabetes. Kidney damage due to diabetes often persists despite treatment with the best available drugs. Most people with kidney damage from diabetes are overweight. Drug and surgical weight loss treatments help overweight people to lose m... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_aef73df45e332860f7b17c38d880b6c1 | Respiratory immune responses and their interaction in control of nasal colonization with Bordetella pertussis and Staphylococcus aureus in humans | Wellcome Trust | Trinity College Dublin | HRCS22_14642 | This research study is designed to examine how the human immune system responds to different types of vaccines and to bacteria that commonly live in the nose, in particular Bordetella pertussis and Staphylococcus aureus. Infection with the bacteria Bordetella pertussis (‘B.pertussis’) causes whooping cough. Vaccines ar... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_3bfcdf8a0ac8d0a2c4140098c49303f7 | Investigation of the role of the VWF-ADAMTS13 axis in the pathogenesis of sickle cell vasculopathy in children | Wellcome Trust | Royal College of Surgeons in Ireland | HRCS22_14643 | Sickle cell disease (SCD) is responsible for major global morbidity and mortality and more than 1,000 SCD children are born every day. Globally over half will die before five years of age and <10% survive to adulthood. Even in developed countries, SCD causes significant morbidity with 10% of US patients developing stro... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_16313cecfacd60dce54a59a7200a6ab9 | Clinical ApplicatioN of DEep Learning and Intelligent Vision in Radiology: CAN DELIVeR | Wellcome Trust | University College Dublin | HRCS22_14646 | The workload associated with medical imaging has greatly increased both in terms of volume and complexity in recent years. The amount of clinicians trained in expert interpretation of these data has however, failed to keep pace with demand. This project encompasses the application of Machine Learning to specific radiol... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_d81980f4a6017cc9992fe030943f0e12 | The DRPLA Natural History and Biomarker Study | Ataxia UK | New York University | HRCS22_14659 | The DRPLA Natural History and Biomarker Study aims to longitudinally collect data in patients affected by DRPLA and gather information from different biomarker modalities in order to facilitate the implementation and development of clinical trials. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_b0e61ed78477fffa2af2b86937163404 | Ultrasensitive assays for tau and aSyn aggregates in AD and PD | Alzheimer's Research UK | Case Western Reserve University | HRCS22_14667 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_ad0a0c66daf52c6eac2da8d42d88c79a | Innate Immune Response | Duchenne UK | Binghamton University | HRCS22_14697 | Targeting the innate immune system to block acute inflammatory and chronic immune responses to transgene and AAV vector in DMD | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_efd137ca5ccbda2299546622d16a7299 | Immunological pathways in Hidradenitis Suppurativa and potential therapeutic targets. | Wellcome Trust | University College Dublin | HRCS22_14698 | Hidradenitis Suppurativa (HS) is a chronic skin condition consisting of abscesses, boils and sometimes scarring in the groin, armpits and under the breasts. It has a severe impact on quality of life. There is dysregulation of the immune system. There is only 1 licensed treatment for moderate to severe HS, adalimumab, a... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_b700854eead57b82316c5ec6ecbe39e8 | Plasma glycated CD59 (gCD59), a Novel Biomarker for the Diagnosis, Management and Follow up of Women with Gestational Diabetes (GDM). | Wellcome Trust | National University of Ireland, Galway | HRCS22_14699 | The frequency of diabetes diagnosed during pregnancy is increasing. The diagnosis for diabetes in pregnancy (DIP) is very long, cumbersome and inconvenient for most women. CD59 is a new blood test that has been shown to be more elevated in people with diabetes than in people without diabetes. The purpose of this study ... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_76eddd47b388a569f98e3426cef4c7a1 | DRPLA Natural History and Biomarkers Study (DRPLA NHBS) | Ataxia UK | University of North Carolina at Charlotte | HRCS22_14709 | Currently, there is no effective treatment for DRPLA, this study objective is to obtain natural history data of the condition, and valid biomarkers, which can be used as outcome measures in order to facilitate the implementation and development of clinical trials. This study will collect longitudinally clinical measure... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_9f4cedcb36809eb64cd171e83fc2080c | Improving help-seeking for depression care in Nepal: Development and testing the feasibility, acceptability and appropriateness of a social contact-based community intervention | Wellcome Trust | Transcultural Psychosocial Organization (TPO) Nepal | HRCS22_14712 | Depression is a highly prevalent mental health condition which has enormous emotional and financial burden on individuals, families, and society as a whole. Despite the availability of effective treatment, a large number of people needing depression care do not receive treatment. Individual often delay or avoid seeking... | 6.6 Psychological and behavioural | 6project_grants_public |
gen_071f04665f6d3fae7e03ae4942d6741a | Improving Understanding of the Biological Basis of Tinnitus: A Multi-Omics Approach in Two Large Cohorts of Women | Royal National Institute for Deaf People | Brigham and Women's Hospital | HRCS22_14716 | There is a critical need to improve understanding of the biological basis of tinnitus, unravel the diverse etiologies that underlie this heterogeneous condition, and advance development of tailored treatments based on a precision medicine data-driven approach. Accumulating evidence suggests complex interactions between... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_c5bd1db0f17656ba5b0ff1a990f0a4ea | Understanding and addressing intimate partner violence (IPV) in forced migrant (refugee) communities in Durban, South Africa | Wellcome Trust | South African Medical Research Council | HRCS22_14723 | Forced migrants’ health is a global concern, especially because forced migration is expected to increase substantially driven by war and human caused climate change [1]. In South Africa, there are approximately 2.1 million forced migrants (refugees). This population experiences poor health, driven by exposure to violen... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_905a99b6e29893f437298a2ae02f4a33 | Investigating the Impact of the International Response to the 2014 West African Ebola Crisis | Wellcome Trust | University of Cape Town | HRCS22_14728 | The 2014 West African Ebola crisis was the deadliest outbreak in this region. While the international response was delayed, eventually international actors, including scientists, clinicians, NGOs, and governments came to the aid of affected countries. What remains unclear is the impact of the international response on ... | 8.3 Policy, ethics and research governance | 6project_grants_public |
gen_f6c305639ac24b0bbc32cf0043d482b3 | MGMT methylation score for predicting benefit from TMZ in patients with IDHmt low grade glioma to guide treatment decisions | The Brain Tumour Charity | University Hospital of Lausanne | HRCS22_14735 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_06d61076710ed2db713f754d3a0c929d | Developing optimized implementation strategies to improve the efficiency of genetic control approaches against malaria vectors in Burkina Faso. | Wellcome Trust | Centre National de la Recherche Scientifique et Technologique | HRCS22_14833 | Genetic control approaches through application of CRISPR/Cas9-based gene drives represent a promising strategy to control vector borne diseases such as malaria. While the technology is still being optimized, there is urgent need to address several knowledge gaps crucial for safe and effective field implementation. One ... | No Research Activity assigned | 6project_grants_public |
gen_2e06fceaa03e09995e0c519a7a4a73c1 | Developing and pretesting a sexual reproductive health and rights (SRHR) school health promotion intervention to reduce sexual transmission of HIV in a high-burden rural setting in KwaZulu-Natal | Wellcome Trust | Africa Health Research Institute | HRCS22_14838 | Adolescents in SA face huge, interlinked epidemic of poor sexual reproductive health (SRH) and high HIV-incidence. Innovative approaches to improve demand and uptake of SRH and HIV-prevention is critical. Schools present an opportunity to deliver effective health-interventions within sustainable infrastructure. The aim... | 3.1 Primary prevention interventions to modify behaviours or promote well-being | 6project_grants_public |
gen_8e7131b42ee9cc353a12af84c8e8e768 | Pharmacometrics to advance novel regimens for drug-resistant tuberculosis (PandrTB) | Wellcome Trust | Institute of Tropical Medicine Antwerp | HRCS22_14841 | PandrTB is a study of the pharmacokinetics(PK) and pharmacodynamics(PD) of bedaquiline, delamanid, clofazimine, linezolid, moxifloxacin, levofloxacin and pyrazinamide used in novel combinations to treat multidrug-resistant tuberculosis(MDR-TB). PandrTB is nested in the endTB trial, a randomized study that will evaluate... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_63b76ed3338a0d7c5b8bf54fe22e7406 | DNA damage-induced nuclear envelope (NE) rupture is a new vulnerability of homologous recombination (HR)-deficient cancers | Worldwide Cancer Research | Institute Curie | HRCS22_14878 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_3c18396b007dcbffbb7500925cfe5e39 | Advancing product development and use of monoclonal antibodies for infectious disease in low and middle income countries (LMICs)’ | Wellcome Trust | World Health Organization | HRCS22_14879 | The project supports activities in the Immunization, Vaccines and biologicalsdepartment of the WHO that aim to advance the product development and use ofmonoclonal antibodies (mAbs) for infectious diseases, with a focus on meeting theneeds of Low and Middle Income Countries (LMICs). Three specific activities will becar... | No Research Activity assigned | 6project_grants_public |
gen_74f9bce0887d516c6da16dd4a1b90732 | Development of Nanoparticle Antibiotic Adjuvant for the Treatment of Chronic Suppurative Otitis Media | Royal National Institute for Deaf People | Stanford University | HRCS22_14902 | We request support to investigate the use of functionalized gold nanoclusters as an adjuvant therapy for chronic suppurative otitis media (CSOM). CSOM is characterized by a chronically discharging infected middle ear that is most frequently caused by Pseudomonas aeruginosa (PA) and Staphylococcus aureus and is a leadin... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_de3cc0f9b634dff35a9965c7ca648cdd | Mapping the miRNA atlas of CF airway epithelial cells using patient-derived gene-edited iPSC | Wellcome Trust | Royal College of Surgeons in Ireland | HRCS22_14903 | CF is the most common lethal monogenic disease in Caucasians with F508del being the most common mutation (>80%). MicroRNA (miRNA) have emerged as key players in disease pathogenesis and are differentially expressed in the CF airway epithelium. Current in vitro models of CF do not represent the genetic background of ind... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_12830ba0b84652dc3700dad5ffac3080 | Optimization and pharmacokinetics of allele-specific antisense oligonucleotide therapy for late-onset sensorineural hearing impairment DFNA9 | Royal National Institute for Deaf People | Radboud University Nijmegen Medical Centre | HRCS22_14927 | BACKGROUND: Hearing loss (HL) is the most prevalent and disabling sensory deficit worldwide. The c.151C>T founder mutation in COCH (DFNA9) is amongst the most important causes of (dominantly) inherited, adult-onset HL and affects >1,500 Dutch and Belgian individuals. Hearing aids or cochlear implants can relieve part o... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_7d2a1877f19c68d5897e3b416f55241f | Assessing the impact of a new class of insecticide treated net (Interceptor G2) on malaria vectors population dynamics, ecology and behaviours in the Cascades Region of Burkina Faso. | Wellcome Trust | Centre National de Recherche et de Formation sur le Paludisme | HRCS22_14996 | Long-Lasting Insecticide-Treated Nets (ITNs) are the most successful method for malaria vector control in Africa. Growing evidence indicates changes in mosquito vector biting and resting behaviours in several African settings where high ITN coverage has been achieved. These combined with growing resistance to pyrethroi... | 3.2 Interventions to alter physical and biological environmental risks | 6project_grants_public |
gen_bb280b84b4581f47a92e54cf1b6c44d8 | Identification of genetic modifiers modulating the diseases severity of LMNA-CMD | Muscular Dystrophy UK | INSERM | HRCS22_15011 | LMNA gene mutations are responsible for a wide spectrum of disorders, the majority of which affecting striated muscles with dilated cardiomyopathy. They may be associated with variable severity of muscular dystrophy, i.e. LGMD1B (mild/late muscle phenotype), EDMD (strong/young muscle phenotype) and LMNA-CMD (severe/con... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_356a0fa06c255cf2ed30fb7c7bb6ea91 | Interactive play: a strategy to improve nurturing care and movement behaviours for infants | Wellcome Trust | University of the Witwatersrand | HRCS22_15048 | The persistence of under- and over-nutrition, in conjunction with poor adherence to movement guidelines and lack of stimulation evident among South African children, is indicative of a generation being raised in an environment that is not conducive to optimum early childhood development. This perpetuates an intergenera... | 3.1 Primary prevention interventions to modify behaviours or promote well-being | 6project_grants_public |
gen_b07f7b80e43b703f4e65e7f30e6254ad | Does household food biodiversity protect adults against malnutrition and favour the resilience of Shawi Indigenous households to climate change related events? | Wellcome Trust | Cayetano Heredia University | HRCS22_15093 | Undernutrition is a major consequence of climate change. Biodiversity could enhance climate change resilience of local food systems by improving human nutritional outcomes and providing healthy local food resources during/after climate-related risks. What is unclear, however, is how food biodiversity (FBD) is linked to... | 2.3 Psychological, social and economic factors | 6project_grants_public |
gen_d0abbb2ca61ad749be85e50c45d995c1 | Understanding the drivers of persistent malaria transmission in a region targeted for elimination in southern Mozambique | Wellcome Trust | Manhiça Health Research Centre | HRCS22_15109 | Mozambique aims to eliminate malaria in several low transmission zones between 2020-2025 by intensifying core malaria intervention measures including universal coverage with long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS). Successful efforts will also aid in the elimination efforts in n... | 3.2 Interventions to alter physical and biological environmental risks | 6project_grants_public |
gen_bf78627a8e34756a3a729b32a4d16e88 | Risk variants and genetic architecture of ALS in sex- and population-specific subgroups | MND Association | Trinity College Dublin | HRCS22_15137 | Amyotrophic lateral sclerosis (ALS) is significantly heritable, but, despite considerable investment, remains enigmatic in its root causes for the majority of cases. Genomic studies of ALS such as genome-wide association studies have yielded relatively few definitively associated genetic loci and limited insight into t... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_88269b1e3ed71f6f6ded7330d33853d0 | Role of LIN28B-mTOR axis in supporting cell plasticity and hair cell regeneration | Royal National Institute for Deaf People | Johns Hopkins University | HRCS22_15169 | The aim of the proposed study is to address whether re-activation of LIN28B-mTOR pathway allows for auditory hair cell regeneration in mammals. Loss of auditory hair cells due to disease or trauma is permanent and is the leading causes for hearing impairments and deafness in humans. Immature auditory supporting cells d... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_edc86eef2bb9158f116b31e57cd9b80f | Development of ALS progNOstic biomarkers based on patterned neural network dysfunction | MND Association | Trinity College Dublin | HRCS22_15174 | Despite substantial heterogeneity of presentation and progression, ALS is currently managed as though it is a single neurodegenerative disorder. With the exception of gene based therapies, most clinical trial designs rely exclusively on clinical parameters to stratify patients into “fast” and “slow” progressors, and on... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_ec8613bfa40f02973c49a9d5e527b411 | Chicken liver and eggshell crackers as a safe and affordable animal-source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind randomised controlled trial | Wellcome Trust | SEAMEO Regional Center for Food and Nutrition | HRCS22_15176 | A double-blind two-phase cluster randomized controlled trial will be conducted in West Java, Indonesia. Total 308 pregnant women will be recruited from 28 clusters (villages) in Sumedang district. Women who fulfil trial criteria will be randomly selected and invited into the trial. Clusters will be randomly assigned to... | 6.1 Pharmaceuticals | 6project_grants_public |
gen_c294380658e78cb7e3db7af7811581f7 | Does neuromodulation have what it takes to silence tinnitus for the long-term? | Royal National Institute for Deaf People | Flinders University | HRCS22_15180 | It is estimated that 1 in 8 people in the UK suffer from chronic tinnitus. Currently, the most effective treatment strategies are psychological management approaches that reduce the distress caused by the tinnitus, but do not change the tinnitus itself, and to date there is no treatment that has a consistent and reliab... | No Research Activity assigned | 6project_grants_public |
gen_f0fcee544948a17f51f81f1af258161f | CLIC5 functions in hearing and deafness | Royal National Institute for Deaf People | Indiana University | HRCS22_15185 | Mutations in CLIC5, which encodes a protein of undetermined function, cause hearing loss by unknown mechanisms. CLIC5 is concentrated at the basal taper region of stereocilia and interacts with taperin, which could modulate the actin cytoskeleton in cochlear hair cells. By performing comprehensive genetic, biochemical ... | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_1ae23bf3ef0d77f55a6275dce06055d1 | Exploring mitochondria-to-nuclear communication in pancreatic cancer initiation | Worldwide Cancer Research | Venetian Institute of Molecular Medicine | HRCS22_15702 | Pancreatic cancer is characterized by poor overall survival and few efficacious therapeutic interventions. One area that has offered significant scope for further exploration are the numerous metabolic disturbances in preclinical models of pancreatic cancer. Several of these derangements lead to imbalances in metabol... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_523da40d5f6202bf97b56f0b157bbeaa | Digital Health Research Programme Year 2 | Cystic Fibrosis Trust | Cystic Fibrosis Canada | HRCS22_15718 | Use smart technologies to explore if it is possible for adults with CF to safely avoid the current routine CF clinic appointments when stable and provide more timely interventions to individuals based on the measurements taken at home. Use advanced analytical tools to interrogate existing UK CF Registry data to addres... | 4.2 Evaluation of markers and technologies | 6project_grants_public |
gen_77bf5807ff4c64e0de0516a6d53c8ff9 | Structural basis of B-cell Receptor-mediated cell-autonomous signalling in chronic lymphocytic leukaemia | Worldwide Cancer Research | Fondazione Centro San Raffaele | HRCS22_15720 | B cell receptor (BcR) signaling is a central event in the pathogenesis of chronic lymphocytic leukemia (CLL). Inhibitors of downstream effectors of BcR signaling display good clinical efficacy, yet have a limited capacity to induce profound clinical responses, and frequently lead to side effects due in part to off-targ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_64c5afa2c2724265bde51231d9c1e17c | Local and Sustained Release of ChondroitinaseABC-37 to the Chronically-Injured Spinal Cord | Spinal Research | University of Toronto | HRCS22_15808 | Chondroitinase ABC (ChASE) is a potent enzyme that has repeatedly shown great promise in spinal cord injury; yet, its inherent instability and the few choices for sustained delivery have limited clinical translation. We invented a more stable and active form of ChASE, ChASE37, and a strategy for sustained local delive... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_be1f717e12a9debecd3a1e5236b46fae | Lassa fever near-patient PCR and haemostasis diagnostics | Wellcome Trust | University of Sierra Leone | HRCS22_15810 | Lassa fever is a life-threatening viral haemorrhagic fever and a major public health burden in West Africa, causing tens of thousands of cases annually with high patient mortality. The signs and symptoms of LF mimic common febrile illnesses in the early phase of the disease which makes diagnosis of the disease difficul... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_3f4b65f8408e2413bfa8a436b6ae5bea | Guidance on methodologies to measure the impact of vaccines on antimicrobial resistance (AMR) | Wellcome Trust | World Health Organization | HRCS22_15817 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_02a46326f5f186f645cf8843ee7f7fe7 | Genetic dissection of factors contributing to disease severity in a fly brain tumour model | Worldwide Cancer Research | Foundation for Research and Technology Hellas | HRCS22_15818 | Since the discovery of oncogenes and tumour suppressors, it is known that a small number of genetic insults can transform healthy cells into precancerous. Decades later, we are still trying to fathom the multitude of additional defects that underlie full-blown malignancy. Model organism cancer models with carefully con... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_36e184fdf57f9b7b200b1facf1f8d943 | Analysis of somatic recombination in lymphoid cells to unravel DNA end joining regulation in cancer | Worldwide Cancer Research | Institut Pasteur | HRCS22_15819 | DNA double-strand breaks (DSBs) are toxic cellular lesions that must be efficiently repaired to maintain genome stability and prevent cancer. The two main DSB repair pathways are homologous recombination (HR) and nonhomologous end joining (NHEJ), with pathway choice partly determined by functional antagonism between th... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_872ce9942af59d3057e9cd587adb7032 | ImmuNOlogy Project | Duchenne UK | University of Florida | HRCS22_15836 | This project is looking at immune responses to gene therapy | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_bd7e074925d2515bf2b64196e759cc5d | Eradicating the minimal residual disease in melanoma | Worldwide Cancer Research | Vlaams Instituut voor Biotechnologie | HRCS22_15847 | Inhibitors of MAPK signalling have led to unprecedented clinical responses in patients with BRAF-mutant metastatic melanoma. However, the clinical benefit of such agents is limited by genetic alterations that occur (by chance) before or during the treatment, leading to intrinsic or acquired resistance respectively. Add... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_60198f8fc0cb08342e546da176afe45b | Innovative aptamer-based approaches to specifically target DNA methylation in non-small-cell lung cancer | Worldwide Cancer Research | National Research Council | HRCS22_15859 | The development of effective therapeutics has become an unmet need to reduce non-small-cell lung cancer (NSCLC) patient’s mortality. DNA methylation is a key epigenetic modification regulating gene expression and its alteration is the most common molecular lesion in several cancers, including NSCLC. It thus offers an i... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_e5d1701eb09be5fb118afc4446962f43 | Using crowdsourcing to identify, characterize and target swarms of Anopheles funestus mosquitoes in rural Tanzania | Wellcome Trust | Ifakara Health Institute | HRCS22_15897 | Malaria burden in Tanzania has significantly declined following scale-up of long-lasting insecticide treated nets (LLINs)6. In some areas such as rural south-eastern Tanzania, Anopheles gambiae s.s, which was previously the number one vector has also disappeared under the intervention pressures. Unfortunately, a differ... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_344fd6a1c846074bcdaa0f25efbb5938 | Characterizing the role of regulatory T (Treg) cells in the progression of aggressive mesenchymal-type colorectal cancer | Worldwide Cancer Research | University Medical Center Utrecht | HRCS22_15915 | Colorectal cancer (CRC) is one of the most common types of cancer in the Western world and the second most common cause of cancer-related mortality. Analysis of recurrent patterns of gene expression in CRC has led to the identification of four Consensus Molecular Subtypes (CMS1-4). Of all newly diagnosed CRC cases in t... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_aa62356b940a5017ecbef97f6f71f0d9 | Determining the effects of pediatric vaccination status on the burden of antimicrobial-resistant commensal organisms in a Guatemalan community | Wellcome Trust | Washington State University | HRCS22_15937 | We are initiating a CDC-funded study of antimicrobial-resistant bacteria in the western highlands of Guatemala. This study is in collaboration with investigators at Washington State University (WSU, USA), University de Valle de Guatemala (UVG), the Guatemalan Ministry of Health and Social Assistance (MSPAS), and the Ce... | No Research Activity assigned | 6project_grants_public |
gen_96461c188c1a0244749f711917598c1f | Effectiveness of vaccines to prevent antibiotic prescribing for acute respiratory tract infections in high risk adults | Wellcome Trust | UNSW Australia | HRCS22_15956 | In high income countries the greatest use of antibiotics is in community (primary care) settings in the context of acute respiratory tract infections. Within these settings, both the very young, the very old and those with respiratory conditions such as asthma and chronic obstructive pulmonary disease are known to be t... | 7.3 Management and decision making | 6project_grants_public |
gen_7b966e822bb74ccfcb4ef3c9b4c6c56c | Targeting the innate immune system to fight glioblastoma | The Brain Tumour Charity | Mass General Brigham | HRCS22_15959 | No abstract available for this analysis. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_ca017a35b62e2fd0cd664442e2e8abef | Strategies to optimize use of MDM2 inhibitors in glioblastoma multiforme | The Brain Tumour Charity | Dana Farber Cancer Institute | HRCS22_15960 | No abstract available for this analysis. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_7aed67abb06d5b0079825ef6f464d9eb | Targeting astrogliosis to ablate post-treatment tumour recurrence | The Brain Tumour Charity | University Hospital of Lausanne | HRCS22_15961 | No abstract available for this analysis. | 2.1 Biological and endogenous factors | 6project_grants_public |
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