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gen_42ecc64bc4961485414088e6bd111f13 | Strengthening the quality of adolescent primary healthcare in South Africa: preliminary work on a complex public health intervention | Medical Research Council | University of Cape Town | HRCS22_02513 | Over half the world's adolescents live in countries like South Africa, with high levels of communicable and non-communicable diseases, obesity, high adolescent fecundity and unmet need for contraception. Although at increased risk, adolescents are marginalised and face barriers in accessing healthcare. In South Africa ... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_e11c80763c6105790dbc691a3f47f4fd | Building a sustainable model to promote menstrual, sexual and reproductive health (MSRH) amongst secondary school girls in Tanzania | Medical Research Council | Mwanza Intervention Trials Unit | HRCS22_02514 | The project addresses a critical evidence gap in how to comprehensively address menstrual, sexual, and reproductive health (MSRH) challenges of adolescent girls in Tanzania. Poor MSRH is associated with subsequent psychosocial (high levels of shame, depression, anxiety) and physical (pain, increased risk of reproductiv... | 3.2 Interventions to alter physical and biological environmental risks / Research Grant | 6project_grants_public |
gen_4dcac5332114637177cfc2c8bbc1f621 | Impact of prophylactic CPAP in the delivery room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial | Medical Research Council | Mbale Clinical Research Institute | HRCS22_02591 | Complications of prematurity are the leading cause of deaths in children under the age of five and the majority occur in low income countries. The predominant reason for these preterm deaths is respiratory distress syndrome (RDS). In high-income countries (HICs), the use of early CPAP, within 15 minutes of delivery, ca... | 6.3 Medical devices / Research Grant | 6project_grants_public |
gen_3b0381a25647d59d20e3348aa3826957 | Patient-led support groups in the management of hypertension and diabetes in low-resource settings: mixed methods study of an innovative model | Medical Research Council | African Population and Health Research Center | HRCS22_02592 | The long term ambition of this project is to improve the lives of low and middle-income people living with untreated hypertension and diabetes across Africa through a patient-led model of care. Our work is motivated by the rising burden of hypertension and diabetes in a rapidly urbanising Africa and scarce public resou... | 7.3 Management and decision making / Research Grant | 6project_grants_public |
gen_253df1104a294b0ad6fe2cecab7a29f4 | Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa | Medical Research Council | Wits Health Consortium | HRCS22_02609 | South Africa faces a complex health burden with rising non-communicable disease against a background of prevalent infection. Malnutrition, undernutrition alongside overweight/obesity, is widely prevalent, imposing risks along the life course especially among adolescent girls. We propose an intervention to optimise adol... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / Research Grant | 6project_grants_public |
gen_833483a3b797d0af3da128dc5c173ac1 | Nutrition-sensitive epigenetic mechanisms in the early human embryo - developing insights from stem cell and organoid models | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02610 | A seasonal 'experiment of nature' in rural Gambia has revealed the presence of DNA methylation (DNAm) hotspots sensitive to periconceptional environment. These are enriched for metastable epialleles, endogenous retroviruses and parent-of-origin-specific methylation (PofOm) suggesting establishment in the early embryo. ... | 1.1 Normal biological development and functioning / Research Grant | 6project_grants_public |
gen_61e7ee6934863ca7044e0f6f5f26b569 | Duration of protection and density of colonisation following pneumococcal conjugate vaccination with a booster dose | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02653 | Global control of pneumococcal disease is hampered by the cost of PCV. More than 20 countries are projected to 'transition' from GAVI vaccine subsidies in the next 5 years. Continuation of PCV programmes will require substantial increases in country expenditure on PCV. Gambia introduced a three-dose PCV schedule withou... | 3.4 Vaccines / Research Grant | 6project_grants_public |
gen_d3bd0c6fc044e0a3ea8d3c62db41f0ee | Doctors under siege: Making sense of the rising incidence of violence against doctors in India. | Medical Research Council | Gokhale Inst of Politics and Economics | HRCS22_02673 | Society grants medical professionals' status, respect, and privilege with the expectation that physicians would be competent, altruistic, moral, and conscientious. A well-functioning social contract and a harmonious relationship between the medical profession and the people it serves is essential for a country's health... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_eedd5125a586004fada1a8fde287dcb5 | Developing an mHealth intervention to strengthen the community mental health system in the context of the COVID-19 pandemic in Peru | Medical Research Council | Cayetano Heredia University | HRCS22_02674 | The COVID-19 pandemic and the mandatory social distancing have made visible the challenges the Peruvian health system faces to provide remote care. People with mental disorders are particularly vulnerable in this context, due to the impact of the pandemic on their health, as well as the limitations in accessing service... | 2.3 Psychological, social and economic factors / Research Grant | 6project_grants_public |
gen_7bea01300256253bac06fc70ef3b2649 | Strengthening the health system for a people-centred community orientation in South Africa. A formative study. | Medical Research Council | University of KwaZulu-Natal | HRCS22_02675 | Health systems in sub-Saharan Africa are typically fragile, reactive and vertically organised - being ill-equipped to deal with multiple co-existing health problems, such as malaria, tuberculosis, HIV and non-communicable diseases; as well as emerging shocks such as COVID-19. The Lancet Commission on the future of heal... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_3422cc2e13123f66fd290d014a5fb403 | Promoting Universal Health Coverage for Amputees through Social Enterprise and Engineering Innovation | Medical Research Council | Makerere University | HRCS22_02677 | In Uganda, as in many other LMICs, prosthetics services have been developed, and supported by international NGOs (e.g. ICRC), in humanitarian responses to conflict. When support is withdrawn, post-conflict, health systems struggle to integrate and maintain such services. Despite the government's commitment to universal... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_0b4fb628510513c6891cac82e4c03105 | Learning health systems: fostering participatory learning and action to equip rural health workers as change agents for maternal and newborn care. | Medical Research Council | South African Medical Research Council | HRCS22_02686 | Our study aims to create a culture of organizational learning within rural health facilities towards maternal and newborn health (MNH) care quality improvements. We will evaluate an innovative health system strengthening approach in rural KwaZulu-Natal, South Africa (SA) using participatory learning and action (PLA) gr... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_91184a03ca8f605c6c98c39751790358 | Developing Strategies to coordinate HEalthcare provision between The GAmbia and Senegal (SHEGAS) | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02688 | An increasingly mobile global population (there were an estimated 1 billion international and national migrants in 2019) poses challenges to policymakers, who must ensure their health systems can provide good quality healthcare to an increasing number of patients with diverse health needs. This is a particular challeng... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_34886efec3a32ee3dbdd9f49abb6cd8d | Gates Foundatoin | Arcady Group, LLC | INV-024993 | to improve the adherence to TB treatment, this grant will help address the market access, uptake, implementation, and utilization challenges of digital adherence technologies in low-middle-income countries | Agricultural Development / Global Health | 4other_research_funding | |
gen_14eb09d49c92711a1085bfafcccafa09 | SARS-CoV-2 infection, transmission dynamics and household impact in Malawi (SCATHIM) | Medical Research Council | University of Malawi | HRCS22_02717 | Sub-Saharan African countries have adopted prevention measures similar to those used in developed countries to combat the SARS-CoV-2 virus (COVID-19) pandemic, although their social, cultural and economic contexts are markedly dissimilar. Limited empirical data exist on SARS-CoV-2 transmission dynamics and the feasibil... | 2.3 Psychological, social and economic factors / Research Grant | 6project_grants_public |
gen_d78cc0b99ed8b7ea24bef86ac7c48761 | To investigate the spectrum, determinants and long-term outcome of SARS-CoV-2 in African children, immune responses and protective role of prior sHCoV | Medical Research Council | University of Cape Town Lung Institute | HRCS22_02720 | To prospectively investigate SARS-CoV-2 in African children, we will leverage 2 ongoing cohorts: (i) the Drakenstein Child Health Study (DCHS), a birth cohort study with comprehensive longitudinal measurement of risk factors, a very well phenotyped population and large biobank of samples. Children will be followed for ... | 2.1 Biological and endogenous factors / Research Grant | 6project_grants_public |
gen_6859c540590f0117e2cd7e34b836b99a | Evaluation of low birth weight infant post-discharge outcomes and development of community-based follow-up and monitoring strategies in Africa | Medical Research Council | Aga Khan University, Kenya | HRCS22_02738 | Globally, every year 2.5 million newborns die. Low birth weight (LBW) infants (birth weight< 2,500g) who constitute 15% of all newborns, have the highest risk of mortality and adverse long-term growth, health and neurodevelopmental outcomes. They include both preterm and intrauterine growth restricted infants and major... | 8.1 Organisation and delivery of services / Research Grant | 6project_grants_public |
gen_48d0cb4fdcb3cad21d7f47725486f2b9 | Host-virus interactions in KSHV-related malignancies: evaluating the role of STIP1 as a therapeutic target | Medical Research Council | Rhodes University | HRCS22_02739 | Molecular chaperones are essential for protein homeostasis. Hsp90 and Hsp70 function as broad host factors for viral protein folding and are essential for both KSHV latent and lytic replication cycles. As such, we believe KSHV is exquisitely sensitive to perturbations in molecular chaperone systems and inhibition of th... | 2.1 Biological and endogenous factors / Research Grant | 6project_grants_public |
gen_bfc56ae67e7702f03548d849eb1652da | Development and pilot testing of an m-health intervention to reduce COVID-19 associated psychosocial distress among Nigerian healthcare workers | Medical Research Council | Obafemi Awolowo University | HRCS22_02740 | The advent of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) across the globe has brought severe disproportionate distress on individuals, communities, health resources, and nations. The distress is increasingly eroding the mental health and wellbeing of patients and caregivers in c... | 7.1 Individual care needs / Research Grant | 6project_grants_public |
gen_676761ae23c8340d11d6169719025221 | Two-way risk communication mobile application versus traditional methods of adverse drug reaction reporting in Uganda: a randomized controlled trial | Medical Research Council | Makerere University | HRCS22_02798 | There is an urgent need to improve pharmacovigilance in Uganda. Despite efforts to improve reporting using web- and paper-methods, adverse drug reaction (ADR) reporting by healthcare professionals (HCPs) remains critically low. We aim to complete a cluster-randomised controlled trial to evaluate the effectiveness of a ... | 7.3 Management and decision making / Research Grant | 6project_grants_public |
gen_06c6ecea0ed0536adf1d12eef879141c | Healthcare and Socio-economic Impacts of COVID-19 on Patients with Diabetes in Tanzania and Kenya | Medical Research Council | Ifakara Health Institute | HRCS22_02810 | This project will provide much-needed, timely and unique evidence from rural and urban areas of neighbouring East African Countries (Tanzania and Kenya) with different approaches to the control of COVID-19. The project aims to explore the experiences of people with type 2 diabetes (T2D) and healthcare providers on mana... | 2.3 Psychological, social and economic factors / Research Grant | 6project_grants_public |
gen_2c212af183572baecb85a93cdc6d40c7 | The Impact of COVID-19 Control measures on NCD risk factors and Metabolic health: A comparison of 3 Caribbean countries | Medical Research Council | University of the West Indies | HRCS22_02824 | Low and middle income countries (LMICs) have a disproportionate burden of noncommunicable diseases (NCDs) and limited resources for prevention and treatment. The COVID-19 pandemic has served to highlight and also exacerbate these disparities. With limited resources for tertiary level care and no evidence-based treatmen... | 2.4 Surveillance and distribution / Research Grant | 6project_grants_public |
gen_942fe357e14805c1a47cfa34a4a226d4 | HPV, STI and AMR in West Africa: estimating population burden and understanding exposures to accelerate vaccine impact and drive new interventions | Medical Research Council | London School of Hygiene and Tropical Medicine | HRCS22_02905 | This multi-stage, probability-based, cluster survey will be undertaken within an established Health and Demographic Surveillance System in The Gambia. It will generate key data on the population prevalence of human papilloma viruses - associated with cervical cancer, other sexually transmitted infections, viral hepatit... | 4.4 Population screening / Research Grant | 6project_grants_public |
gen_2497b399a10afd516fdcbb835051b1bc | C-it DU-it: Community Data Use for Integrated ANC | Department of Health and Social Care | LVCT Health Healthy Societies | HRCS22_05095 | Facility and community health data is rapidly changing from paper to electronic across Kenya. Multiple digital systems are being developed, but these do not link. Community health volunteers (CHVs) and facility staff need to work together using data to monitor and improve uptake of services. Antenatal care (ANC) is an ... | 8.1 Organisation and delivery of services / GHPSR | 6project_grants_public |
gen_201c9a1786a10172416d9d284dcfc6e7 | Community Voices in Health Governance - Translating Public Participation Into Practice in a World of Pluralistic Health System | Department of Health and Social Care | University of Cape Town | HRCS22_05098 | India, Brazil and South Africa are countries with public health care systems, that assure some space, even if nominal, for citizen participation in its daily routines. This proposal focuses on ongoing changes in these systems, which increasingly rely on new ways of combining public and private provision, calling attent... | 8.1 Organisation and delivery of services / GHPSR | 6project_grants_public |
gen_b4d89fd8b4017aa8877611b42a46d9b1 | Implementation of the COmmunity HEalth System InnovatiON Project, COHESION - I | Department of Health and Social Care | Cayetano Heredia University | HRCS22_05108 | The COmmunity HEalth System InnovatiON (COHESION) project was a 3-year project that started in 2016 as a collaboration between research teams from Mozambique, Nepal, Peru and Switzerland. It enabled formative research to be conducted at policy, health system and community levels using tracer chronic conditions that inc... | 8.1 Organisation and delivery of services / GHPSR | 6project_grants_public |
gen_faf16b0543fea2c65c533517eb6686c2 | Strengthening health systems by addressing community health workers’ mental wellbeing and agency | Department of Health and Social Care | BRAC James P. Grant School of Public Health, BRAC University | HRCS22_05118 | Community Health Workers (CHWs) are the backbone of the health system. In remote rural and slum settings, they are often the only point of contact with formal health services for many communities. COVID-19 has demonstrated how CHWs are critical in ensuring adaptability of health systems during crises. Supporting CHWs i... | 7.1 Individual care needs / GHPSR | 6project_grants_public |
gen_08506b1104dd062a5e75254e37b26168 | Calling time on avoidable morbidity from asthma in African children | Department of Health and Social Care | University of KwaZulu-Natal | HRCS22_05425 | Research question In a poor rural population in KwaZulu-Natal using a pragmatic adaptive randomised controlled trial in 2028 children and adolescents to answer the questions: a) Is a combination inhaled steroid/ fast onset long acting 2 agonist (ICS/LABA) clinically effective? b) Is the ICS/LABA cost-effective compared... | 6.1 Pharmaceuticals / NIHR Professorships | 6project_grants_public |
gen_f1c6fda9cb13b725cb0fd1b713ed14f3 | Psychosocial, Pharmacological, and Legal Interventions for Improving the Psychosocial Outcomes of Children with Substance Misusing Parents | Department of Health and Social Care | Saint Louis University | HRCS22_09156 | Global estimates indicate approximately 5-10 per cent of children are raised in families where parents misuse alcohol or other drugs. Extensive research documents the adverse health, developmental and psychosocial outcomes for children raised in these families. Parental substance misuse also typically co-occurs with mu... | 6.1 Pharmaceuticals / ESP | 6project_grants_public |
gen_69c0a193ee13b6fb14ea87c8667f6fe5 | Physical interventions to interrupt or reduce the spread of respiratory viruses | Department of Health and Social Care | Cochrane Acute Respiratory Infections Group | HRCS22_09162 | Acute respiratory infection (ARI) is the leading cause of infectious disease morbidity and mortality and imposes a significant burden on healthcare systems. Viral epidemics or pandemics of ARIs pose a global threat, such as severe acute respiratory syndrome (SARS) in 2003, influenza (H1N1) in 2009, and the current coro... | 3.1 Primary prevention interventions to modify behaviours or promote well-being / ESP | 6project_grants_public |
gen_a7e46f85eae7e2fb6d3fc75bf238e521 | Individual-level interventions for reducing occupational stress in healthcare workers | Department of Health and Social Care | AMC Medical Research B.V. | HRCS22_09169 | In the UK, one in ten workers are employed in health and social care. In 2020, 104,000 healthcare workers suffered from work-related stress, depression or anxiety. This is around half of all ill health among healthcare workers.(1) Financial and non-financial costs are high and quality of care is in jeopardy. Total econ... | 6.6 Psychological and behavioural / ESP | 6project_grants_public |
gen_fcad1299ca937d2d814e05a424d9ee70 | Semaphorin/plexin interactions in regenerative neurogenesis in zebrafish | Biotechnology and Biological Sciences Research Council | Technical University Dresden | HRCS22_10421 | Zebrafish, in contrast to mammals, show regeneration of neurons after spinal cord injury. The immune reaction to injury promotes regenerative neurogenesis in zebrafish, but how cross-talk between immune cells and neural progenitors occurs is poorly understood. We hypothesize that immune cells signal directly to neural ... | 1.1 Normal biological development and functioning / Responsive Mode | 6project_grants_public |
gen_114483ea722399c85085658dbff6b5fb | Demonstrating impact of mosquito-assisted larviciding (autodissemination) as a complementary malaria intervention in rural Tanzania | Wellcome Trust | Ifakara Health Institute | HRCS22_11808 | Long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS) have significantly reduced malaria burden across sub-Saharan Africa [1], but are increasingly threatened by challenges such as mosquito resistance against common public health insecticides [2]. This necessitates innovative complementary to... | 3.2 Interventions to alter physical and biological environmental risks | 6project_grants_public |
gen_0ea836ee661b74669e424848b841d63b | OA fee for terminated award | Wellcome Trust | Stellenbosch University | HRCS22_11931 | In South Africa, where access to mental health services is poor, the risk of developing mental health issues among children and adolescents is high. Accordingly, there is an urgent need to implement cost-, and time-effective interventions to address these issues in child-friendly, and child-accessible settings. Evidenc... | 6.6 Psychological and behavioural | 6project_grants_public |
gen_739095f6c25491109758813620f0670e | OA fee for Innovator Award | Wellcome Trust | Rare Partners (Italy) | HRCS22_11950 | The availability of funding will allow completion of a first exploratory clinical trial on sirolimus. This would be the first trial with the drug in thalassemia, will involve about 20 patients and will explore a surrogate end point known as an important point in thalassemia, namely HbF. The trial will also explore othe... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_e86be71603b0f1c86b31a51e8b816180 | Open access for terminated award | Wellcome Trust | Fred Hutchinson Cancer Center | HRCS22_11959 | Oral cholera vaccines (OCV), administered in two doses, have emerged recently as a powerful tool for short-term outbreak control. When resources are limited, single-dose vaccination has been used as a way to stretch the supply, however, previous studies have shown that a single dose of vaccine is less effective, and wa... | 3.4 Vaccines | 6project_grants_public |
gen_c067ed8dbbb26d95c34f21714301083d | Identification of key immunogenic post-translational modifications in Trichohyalin: a potential major autoantigen in Alopecia Areata | Alopecia UK | University College Dublin | HRCS22_12096 | This project is aimed at discovery of HF-associated autoantigens in AA. Strong evidence for TCHH as a major AA autoantigen in humans as well as in several other mammals is intriguing. Given that TCHH is a substrate for immunogenic PTMs citrullination and deamidation, we speculate that there might be an abnormal immune ... | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_dfe241ee3579ffe643c8a0f7dfa0c8c1 | HIGH PERFORMANCE POLYHYDROXYALKANOATES BASED PACKAGING TO MINIMISE FOOD WASTE | European Commission | BIOINICIA SL | CORDIS-773872 | The main objective of YPACK is the pre-industrial scale up and validation of two innovative food packaging solutions (thermoformed tray and flow pack bag) based on PHA, with active and passive barrier properties. New packaging will use food industry by-products (cheese whey and almond shells), assure the biodegradabili... | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 0business_rnd_innovation |
gen_cbfad69536755c5eb5f0e3a0bfdaf899 | Motor and cognitive outcomes of non-invasive transcranial alternate current stimulation by entrainment of cerebellar oscillations | Ataxia UK | University of Brescia | HRCS22_12176 | Transcranial alternative current stimulation (tACS) is a non-invasive brain stimulation technique, which is thought to modulate physiologically relevant brain oscillations by a desired frequency. Cerebellar ataxias are characterised by loss of Purkinje cells, which have been shown to oscillate in the gamma frequency ba... | 6.5 Radiotherapy and other non-invasive therapies | 6project_grants_public |
gen_302bffaf5ea5325e4e91c04354d17b21 | Opinions of patients with psychosis, caregivers and key stakeholders on informed consent for research involving people with mental health conditions | Wellcome Trust | University of Botswana | HRCS22_12234 | Research involving people with mental health conditions (PWMHC) has its unique ethical challenges. Conducting research among human participants requires obtaining informed consent. However, PWMHC may have impaired decision-making capacity, which may invalidate consent. Often, surrogates are resorted to for consent whic... | 8.3 Policy, ethics and research governance | 6project_grants_public |
gen_66b93a78d1bdd82b873b841ca728e463 | NanoSCA3: Development of brain-targeted nanobodies for application in spinocerebellar ataxia type 3 therapy | Ataxia UK | i3S consortium | HRCS22_12235 | SCA3 is caused by the expansion of a polyglutamine segment in the ataxin-3 protein, which accumulates protein aggregates. Small variable domains of camelid heavy-chain-only antibodies, known as nanobodies, show promise as therapeutic anti-aggregation agents for other neurodegenerative disorders, such as Parkinson’s Dis... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_6fce11c9c8b47b6bee4d40bf4f715117 | Identifying ethical issues in conducting research with transwomen in India | Wellcome Trust | George Institute for Global Health | HRCS22_12258 | Research on trans communities including transwomen is extremely limited in India, inspite of the huge social and political injustices that they have suffered over ages. Trans communities are often a closed community and in India many of them become part of 'gharanas'. The gharana system is an institutionalized lifestyl... | No Research Activity assigned | 6project_grants_public |
gen_ae0ace450b4fb3919b3389caaca3094d | The role of governance and ethical considerations of mental health research on children and adolescents: A pragmatic framework using mixed method Delphi process | Wellcome Trust | Jos University Teaching Hospital | HRCS22_12272 | The prevalence of children and adolescents (C&A) with mental health conditions is increasing globally. More attention is given to infectious diseases and a paucity of mental health research on C&A exists. This area remains neglected because of lack of effective governance, particularly in LMICs. Effective C&A mental he... | 8.3 Policy, ethics and research governance | 6project_grants_public |
gen_5d50dc46398fcdc8edba60e4878bece0 | A randomised, single blinded, prospective study to compare simulated daylight photodynamic therapy with natural daylight photodynamic therapy for treatment of actinic keratoses. | British Skin Foundation | St. Vincent's University Hospital | HRCS22_12286 | Actinic keratoses (AKs) are dysplastic epidermal lesions considered to be potential precursors of squamous cell carcinoma (SCC). Various studies have 2011 and 2015 inclusive there were 70 deaths per year attributed to keratinocyte cancers. Thus treatment of AKs prior to conversion to SCC is important. Photodynamic ther... | No Research Activity assigned | 6project_grants_public |
gen_22f090e2c04a8004ccaa0bc097434243 | Exploring the feasibility, acceptability and potential impact of an ultra-brief online well-being programme for caregivers of children with tuberous sclerosis complex (TSC) in South Africa and the United Kingdom | Tuberous Sclerosis Association | University of Cape Town | HRCS22_12292 | Background. To date, very little attention has been given to the mental health and well-being of caregivers of children with disabilities and chronic conditions, including caregivers of children with tuberous sclerosis complex (TSC). Acceptance and commitment therapy (ACT) has shown promise in improving the well-being ... | 6.6 Psychological and behavioural | 6project_grants_public |
gen_9dea8c67c35d45933af769c06614fecc | Aetiologies, clinical presentation and neuro-cognitive outcomes of non-HIV associated encephalitis in Cameroon - exploring a neglected disease in a low income African country. | The Encephalitis Society | Filariasis and other Tropical Diseases Research Centre (CRFilMT) | HRCS22_12332 | Acute infectious encephalitis is a frequent infectious disease associated with high mortality rates. It is caused by different etiologic agents and manifests with a wide range of clinical signs. Encephalitis management guidelines in low- and middle-income countries (LMIC) are limited by the absence of local epidemiolog... | 4.2 Evaluation of markers and technologies | 6project_grants_public |
gen_a14710be55e22900e602294257c2f45a | Getting ready to solve the unsolved for SLC26A4 | Royal National Institute for Deaf People | Radboud University Nijmegen Medical Centre | HRCS22_12333 | [none] | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_1397089b0e2f0dcf8974ad882f290bbe | Developing a novel host transcript-based test to diagnose scrub typhus in children with acute encephalitis syndrome | The Encephalitis Society | National Institute of Mental Health and Neurosciences | HRCS22_12359 | Encephalitis, swelling or inflammation of the brain, is a serious global health problem, leading to death of up to one-third of people affected by it, and around half of survivors not recovering fully. Recent research has shown scrub typhus as a major cause of encephalitis in children in India. Scrub typhus is an infec... | 4.2 Evaluation of markers and technologies | 6project_grants_public |
gen_9f94ce80c375c26954cef1b127471e4a | Physiological characteristics of stimulation sites in auditory brainstem and cochlear implants | Royal National Institute for Deaf People | New York University | HRCS22_12365 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_c731116f5cb1d58c832f38a7ae8ca4a4 | Role of striatum in tinnitus pathophysiology | Royal National Institute for Deaf People | National University of Central Buenos Aires | HRCS22_12366 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_92401146eaf24fc58fdf847ced2d747f | iPSC-derived human spiral ganglion models: a pilot study | Royal National Institute for Deaf People | University of Zurich | HRCS22_12367 | [none] | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_c71c4a42b096f7c7b55fbb36bf74de3a | Targeting cellular senescence to slow age-related hearing loss | Royal National Institute for Deaf People | University Medical Center Groningen | HRCS22_12368 | [none] | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_6c817fc243ef9a3f0cf66bdcfaff8b93 | Mechanism-based Approach to Optimization of Noise Reduction in Hearing Aids: Influence of Individual Traits on Outcomes and Preference | Royal National Institute for Deaf People | Purdue University System | HRCS22_12369 | [none] | 1.2 Psychological and socioeconomic processes | 6project_grants_public |
gen_d616e1269ff8fb481c15e8046e452221 | Study of otos genes expression and function in the zebrafish inner ear | Royal National Institute for Deaf People | Mount Desert Island Biological Laboratory | HRCS22_12370 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_6956ecca0f9c41477114e28cd48ac1cd | Assessment of hearing disability in children with auditory neuropathy using novel objective methods | Royal National Institute for Deaf People | Bionics Institute | HRCS22_12371 | [none] | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_be95528c11f43eec9c3d52fd6b91a711 | Investigating the dysregulation of cellular metabolism in hidradenitis suppurativa patients and whether metformin can reverse this altered metabolism | British Skin Foundation | Trinity College Dublin | HRCS22_12383 | Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting approximately 1% of the population. It is characterised by painful nodules and lesions in intertriginous areas of skin. Despite having similar prevalence to psoriasis, the disease is under-recognised, under-diagnosed and its pathogenesis is poorl... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_b11ccc745636637bf2303c58b440e910 | Data-driven drug discovery for AT – interrogation of dysfunctional pathways at single-cell resolution in cerebellar organoids | Ataxia-Telangiectasia Society | QIMR Berghofer Medical Research Institute | HRCS22_12390 | Interrogation of dysfunctional pathways at single-cell resolution in cerebellar organoids | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_17e5b3f919876a82f19877c0946da0d0 | Study of natural killer cells in AT pathogenesis and their therapeutic implications | Ataxia-Telangiectasia Society | University of Rome Tor Vergata | HRCS22_12391 | Study of natural killer cells in AT pathogenesis and their therapeutic implications | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_fb15e591049c7d9e4d03dacf038216bb | Implementing an hospital-based encephalitis surveillance in Senegal to decipher main causes of viral encephalitis in a West-African Low-Income Country. | The Encephalitis Society | Institut Pasteur de Dakar | HRCS22_12397 | The main objective of the project is to characterize the aetiology and the clinics of the encephalitis hospitalized in Senegal. To reach this objective, three specific aims have been identified: Specific aim 1: Detect and estimate prevalence of the different viruses associated to encephalitis. Specific aim 2: Describe ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_310f131b168c26beedde33e215fd4a0e | Genetics of Mitochondrial Diseases | Medical Research Foundation | Venetian Institute of Molecular Medicine | HRCS22_12411 | In “Mitofight” we are engaged in developing suitable therapeutic approaches against mitochondrial disorders in mouse models with a particular but not exclusive emphasis on Pearson syndrome and related conditions associated with instability of mtDNA. The creation of mouse models has to be followed by their characterisat... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_6cd93e1b18f8fe31a7f5a127a050723e | The immunopeptidome of paediatric high-grade osteosarcoma | Myrovlytis Trust | St Anna Children's Hospital | HRCS22_12623 | Success rates in treatment of osteosarcoma (OSA), an aggressive cancer affecting children and adolescents, have not improved over the last 30 years. High-dose, multi-agent chemotherapy followed by radical surgery has remained the standard of care. Clearly, there is an unmet need for novel, personalized therapeutic appr... | No Research Activity assigned | 6project_grants_public |
gen_7cf4b35edcaf88ac9b516dfaec95e02f | Etravirine as a potential therapeutic for Friedreich's ataxia | Ataxia UK | University of Rome Tor Vergata | HRCS22_12661 | Friedreich’s ataxia is the most common inherited form of ataxia and is caused by a mutation in the frataxin gene, which decreases the production of frataxin protein. This group recently showed that etravirine, an anti-retroviral drug currently in use as a therapeutic for HIV-positive patients, is able to upregulate fra... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_5e78f61a4ae8293d85fd1130a4889e5a | Assessment of ataxia severity under real-life conditions with SARAhome: A multicenter study in spinocerebellar ataxia type 3 (SCA3) | Ataxia UK | Helmholtz Association of German Research Centres | HRCS22_12662 | The aim of the project is to study ataxia severity under real-life conditions in a large cohort of spinocerebellar ataxia type 3 (SCA3) patients. To this end, the researchers will employ SARAhome, a newly developed video-based digital assessment tool. The study will be performed as a substudy of the ESMI cohort. This s... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_983ac36f6dc1e6ea98a7b43ffb60db6d | AT cerebellar neurodegeneration and inositol phosphate signaling | Ataxia-Telangiectasia Society | University of Texas at Austin | HRCS22_12703 | AT cerebellar neurodegeneration | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_1e8da9d2a75074b0c084c310a2c457c2 | A-T cerebellar neurodegeneration and inositol phosphate signalling | Action for A-T | University of Texas at Austin | HRCS22_12704 | The project will aim to gain a high-resolution view of gene expression in A-T affected tissues and will test hypotheses about inositol phosphate_x0002_regulated calcium signaling and its functional relationship to A-T. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_dd3cc82d574c277aef5e636ec6423ba3 | Liraglutide: A phase II, randomized, double-blinded, placebo-controlled trial of Liraglutide in Parkinson’s disease (Extension 2) | Cure Parkinson's | Cedars-Sinai Medical Center | HRCS22_12746 | Extension to MT011. See above. | 6.1 Pharmaceuticals | 6project_grants_public |
gen_c3f3a3ffbeed13d44c6e039bc4884314 | The CRISTAL Index: Developing a combined response index for scleroderma trials assessing limited cutaneous systemic sclerosis | Scleroderma & Raynaud's UK | University of Michigan Health System | HRCS22_12773 | The project will establish a CRISTAL index which is defined as a combined response index for limited scleroderma, consisting of outcome measures and factors such as gut involvement, quality of life and Raynaud's. The purpose of the CRISTAL index is to create a tool of simultaneous parameters to better understand the ef... | 6.9 Resources and infrastructure (evaluation of treatments) | 6project_grants_public |
gen_9f48c1b17ff96795154c39327bb7aabc | Non-invasive transcranial cerebellar stimulation: double blind, randomised, sham-controlled study followed by an open label extension phase | Ataxia UK | University of Brescia | HRCS22_12778 | Cerebellar transcranial Direct Current Stimulation (tDCS) is a non-invasive treatment which has been demonstrated to modulate cerebellar excitability and improve motor symptoms in patients with neurodegenerative cerebellar ataxias. In a previous study, this group showed that two weeks of tDCS improved symptoms, and thi... | 6.6 Psychological and behavioural | 6project_grants_public |
gen_5b9fc56da39af63d29fc61d37af8897a | Development of a selective high throughput screening assay for the discovery of compounds replacing frataxin in FA | Ataxia UK | University of Paris-Saclay | HRCS22_12811 | Friedreich’s ataxia (FA) is a neurodegenerative condition caused by defective expression of frataxin, a mitochondrial protein of elusive function. This group propose to explore new therapeutic approaches based on pharmacological replacement or enhancement of FXN function. They recently developed an assay which allows t... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_871e421a7574f3817d303e62714ad477 | A translatable peptide reduces glial scar to repair chronic spinal cord injury | Spinal Research | Cleveland Clinic | HRCS22_12859 | Analysing the functional recovery of lower urinary tract assesed by urodinamic and EUS EMG recording and anatomical data. | HRCS Research Uncodeable | 6project_grants_public |
gen_b3a783dff988a34400715973859670c2 | Dissemination and Advocacy of COBRA-BPS Trial Findings to Improve BP Control and Reduce CVD Risk in Rural South Asia | Medical Research Foundation | Duke-NUS Medical School | HRCS22_12894 | Hypertension affects up to one in three adults in South Asia and less than 20% have controlled blood pressure, despite availability in treatment guidelines. Serious gaps in knowledge and practices of physicians in the management of hypertension exist in rural areas, and regular monitoring of BP in hypertensive patients... | 7.1 Individual care needs | 6project_grants_public |
gen_12847dc6df64e90bac7a7bb0d7a58588 | Testing the multimodal anti-depressant vortioxetine as a therapeutic strategy to mitigate SCA3 | Ataxia UK | University of Minho | HRCS22_12897 | Spinocerebellar ataxia type 3 (SCA3) is an inherited ataxia, caused by a mutation in the ATXN3 gene. This group previously demonstrated that modulation of serotonin (5-HT) signalling by the selective serotonin reuptake inhibitor, citalopram, suppressed mutant ataxin-3 aggregation and neuronal dysfunction in SCA3 in viv... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_6b5b5a50c8cebbf9fe53593333396d74 | Development of a PRIME editing therapy for Ataxia-8 due to the c.121 A to T point mutation | Ataxia UK | Laval University | HRCS22_12954 | Spastic ataxia-8 with hypo-myelinating leukodystrophy is an autosomal recessive progressive neurodegenerative disorder, which has been described by Chelban et al. in 2017. It is characterized by onset of primarily motor dysfunction within the first year of life. The patients initially have hypotonia and later develop a... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_d46055ffc83878a8becaaf368d2dc9b6 | Development and validation of a digital tool for identifying young people at risk for depression in South Africa. | Wellcome Trust | South African Medical Research Council | HRCS22_13062 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_66eaf0804ddc0271502b2b17c6b650f4 | Preclinical development of an amelioration therapy for Dentatorubro-Pallidoluysian Atrophy - FUNDING EXTENSION | Ataxia UK | Inserm | HRCS22_13114 | Dentatorubro-Pallidoluysian Atrophy (DRPLA) is a polyglutamine ataxia caused by mutations in the ATROPHIN-1 gene, for which no cure is available. This group have significant experience in models of ataxia and spastic paraplegia with ataxia, and in particular of DRPLA. Following the recent success of antisense oligonucl... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_0c60722e39d70c07595b9c6785f3858b | Advanced in Vitro Test Systems with Integrated Multi-"OMICS" to define Pathway Activation and Treatment Response Scores for Patient Stratification Towards Personalised Medicine in Systemic Sclerosis | Scleroderma & Raynaud's UK | Düsseldorf University Hospital | HRCS22_13174 | Develop a novel toolset for the molecular stratification of ssc patients to ensure they are put on the most appropriate therapies, therefore justifying the potential side effects of these therapies. Precision cut skin slices will be exposed to treatment candidates, monitored, and using biostatics an activation score fo... | 4.2 Evaluation of markers and technologies | 6project_grants_public |
gen_a4fc07539864a55f3175bbcb93799b2b | ROTA-biotic: measuring the impact of rotavirus vaccines on pediatric antibiotic usage | Wellcome Trust | Amsterdam Institute for Global Health and Development | HRCS22_13192 | Antimicrobial resistance (AMR) disproportionately impacts low- and middle-income countries (LMIC) and overcoming AMR requires public understanding and engagement (1,2). The ROTA-biotic project evaluates the impact of vaccines on antibiotic usage in Zambia and Ghana. Caregivers in Zambia and other LMICs are often insuff... | 3.1 Primary prevention interventions to modify behaviours or promote well-being | 6project_grants_public |
gen_f0b14406d66dae8f03ac3598f60cdae5 | Improving care for Birt-Hogg-Dubé syndrome patients: clinical and genetic analysis of a unique cohort. | Myrovlytis Trust | Amsterdam UMC Location VUmc | HRCS22_13206 | We propose a clinical PhD project focusing on the risk of malignancies in Birt-Hogg-Dubé syndrome (BHD) and increasing awareness of BHD. Although the knowledge on the main features of BHD (skin, lungs, kidneys) has increased over the years, many unanswered questions remain that are highly relevant for diagnosis and man... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_c729ab4e0d3a5bcef71160c02146301f | Enhancing sleep to delay the progression of tauopathy | Alzheimer's Research UK | University of Camerino | HRCS22_13250 | Not available | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_092d68c98ebdb8e2b59793a0c0a3fcf3 | Redenlab for the DRPLA Natural History Study (Speech and Dysphagia) | Ataxia UK | Redenlab | HRCS22_13317 | Speech directly effects quality of life (Impaired speech dramatically effects social relationships & employability). Communication typically worsens as disease severity increases in DRPLA. We aim to develop a DRPLA specific speech battery and exploratory measures of language function. | HRCS Research Uncodeable | 6project_grants_public |
gen_dd9af2893d470d77aaa73dd58a08d7ba | Aspartyl Protease Inhibitors as Antimalarials | Wellcome Trust | Walter and Eliza Hall Institute of Medical Research | HRCS22_13322 | Malaria is one of the world's most devastating diseases of humans and results in over 450,000 deaths annually. novel therapies are urgently required to populate the antimalarial clinical portfolio, as the current therapeutics that treat this disease are becoming less effective due to emerging resistance. A collaboratio... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_d9382544a3478f9aae38a9b9b6fd02d2 | Study of the role of the NKG2D/NKG2D ligand axis in A-T pathogenesis and its therapeutic implications | Action for A-T | University of Rome Tor Vergata | HRCS22_13393 | Looking at whether NK cell dysfunctions, including defective NKG2D pathway, have a role in A-T disease progression and provide novel prognostic markers and therapeutic targets. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_2cbfbee88b8b5e5a75b81644f17415ff | Strengthening CAre in collaboration with People with lived Experience of psychosis in Uganda (SCAPE-U) | Wellcome Trust | George Washington University | HRCS22_13405 | Mental health services are most effective and equitable when designed, delivered, and evaluated in collaboration with people with lived experience of mental illness. Unfortunately, people with lived experience are rarely involved in health systems strengthening, and when they are, it is limited to specific components (... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_4138393929ff2d72e37478e3c24465c7 | Generating new Friedreich's Ataxia animal models for validating HSV-1 FXN gene therapy in Dorsal Root Ganglia | Ataxia UK | Autonomous University of Madrid | HRCS22_13428 | In a previous Ataxia UK-funded project, this group generated a novel HSV-1 vector, very similar to one already found to be safe in clinical trials for pain therapy (David Fink, Uni Michigan). They used the natural neurotropism of the vector to deliver a frataxin (FXN) transgene to deeply buried dorsal root ganglion (DR... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_2797be68bf3cad352c1cd8904c720625 | A real-time genome sequencing approach to the role of wildlife in transmission of animal trypanosomiasis | Wellcome Trust | International Centre of Insect Physiology and Ecology | HRCS22_13435 | Animal African trypanosomiasis (AAT) is a major livestock disease restricting economic development across Africa. AAT is caused by trypanosomes (Trypanosoma spp.), which are haemoparasites transmitted by blood-feeding flies; infection causes inflammatory anaemia, resulting in wastage and death if untreated. Prevention ... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_cba64ae81392b6f17e9788311da8168d | Examining the implementation of the Kenya Community Health Strategy in urban informal settlements | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_13436 | The Kenya Community Health Strategy (CHS) is a plan of action to expand community access to health care using - amongst other measures - community health volunteers (CHVs). The CHS has had varying degrees of success with ongoing discussions on how to strengthen it. There is limited information on implementation of the ... | 8.3 Policy, ethics and research governance | 6project_grants_public |
gen_a1c001dced8681de828355a3a462dc1c | Using economic modelling to determine the optimal package of services against non-communicable diseases (NCDs) in South Africa | Wellcome Trust | University of the Witwatersrand | HRCS22_13438 | The goal of this study is to use economic analysis and disease modelling to determine the economic impact of non-communicable diseases (NCDs) in South Africa and to establish how to optimally allocate public-sector resources across NCD interventions. Under this project I will construct a multi-disease health state tran... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_3c9da12b6eebf62ec08823b39bdf6f59 | Antimicrobial Resistant Enterobacteriaceae: Dairy production systems as potential sources of infection for humans in Kenya | Wellcome Trust | International Livestock Research Institute | HRCS22_13441 | Antimicrobial resistance (AMR) is a global health threat, associated with increased morbidity, mortality, and financial costs. Identifying the potential reservoirs of antibiotic resistance and resistance mechanisms is an important task to tackle AMR. Klebsiella pneumoniae and Escherichia coli which can cause severe and... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_416e83bfc002c40f3399df896d2a4255 | Identifying Community Pharmacists Preferences for Attributes of Public Health Interventions Delivered Through Private Retail Pharmacies: A Discrete Choice Experiment | Wellcome Trust | KEMRI Wellcome Trust Research Programme | HRCS22_13442 | Private retail pharmacies are the first point of contact for most people seeking treatment for minor illness in LMICs. They play a significant role in delivery of public health interventions (PHIs). In Kenya, for example, retail pharmacies are involved in the provision of family planning services, HIV counselling and t... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_4fb79fecbe459c5fd62d7a5e92465aae | Identification and stratification of Parkinson’s patients lacking | Cure Parkinson's | St Vincent's Hospital Sydney | HRCS22_13497 | GBA mutations, which impact lysosomal enzyme GCase activity, are numerically the most significant genetic risk factor for Parkinson’s disease (PD). However, the incomplete penetrance of Parkinson’s amongst GBA carriers is surprisingly low and raises the possibility of genetic modifiers that influence GBA expression and... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_28c6383f963a3d412e18f6b1628cfc1b | Investigating the use of the Ataxia Instrumented Measure – Spoon (AIM-S) in measuring upper limb function in Dentatorubral-pallidoluysian atrophy (DRPLA). | Ataxia UK | Murdoch Children's Research Institute | HRCS22_13553 | Dentatorubral-pallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expanded CAG repeat in the ATN1 gene, resulting in a mutant protein (atrophin-1) with a polyglutamine expanded tract. DRPLA is an ultra-rare disease and information regarding its natural history is very limited. To better understan... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_bd030eb973789159b51b9b54d10d4f5a | MicroRNAs in dystrophic epidermolysis bullosa fibrosis: expression profiling, activity and therapeutic perspectives | DEBRA | Istituti di Ricovero e Cura a Carattere Scientifico | HRCS22_13625 | we hypothesize that: (i) miRNAs exert a role in injury-driven fibrosis of RDEB, and (ii) deregulated miRNAs and their targets can be exploited for the design of novel therapeutic approaches to limit RDEB fibrosis. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_d7a5f621235fc08dca67a50bd5389493 | Learning Data Driven Medical Checklists For Multi-Disciplinary Consult Scheduling | Wellcome Trust | University of Toronto | HRCS22_13646 | Checklists are simple tools that are often used to promote safety in clinical applications, because they can easily be integrated into a clinical workflow deployment without the need for extensive training or additional technology. Currently, machine learning in health focuses on large, complex deep neural networks. In... | No Research Activity assigned | 6project_grants_public |
gen_4a44bfe786db86d2da7f9103b025fb74 | Investigating the interplay between early life factors, the genome and childhood cancer risk | Children with Cancer UK | International Agency for Research on Cancer | HRCS22_13649 | The causes of childhood cancer are still largely unknown. Dr Natália Spitz Toledo Dias and her team will investigate whether environmental exposures during a baby’s life in the womb can cause changes to gene activity that may be associated with childhood cancer risk. The ultimate aim is to provide an evidence base for ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_68b442c8034acef7d390305f3b569551 | Hearing loss and dementia: uncovering the mechanisms of accelerated cognitive decline using comorbid preclinical models | Royal National Institute for Deaf People | Western University | HRCS22_13650 | Hearing loss is one of the most prevalent, chronic health conditions worldwide. In addition to age-related hearing impairment, excessive noise exposure is a leading cause of hearing loss. Beyond the devastating effects of hearing impairment itself, there is epidemiological evidence linking hearing loss to an increased ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_f38d111c6b0fc173d666e5d7549ffb1a | Hearing loss and dementia: uncovering the mechanisms of accelerated cognitive decline using comorbid preclinical models | Alzheimer's Research UK | Western University | HRCS22_13652 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_25de19256a03b75a85a8d650655edc32 | The cerebrovascular system: the missing link between hearing loss and dementia? | Royal National Institute for Deaf People | Institut Pasteur | HRCS22_13666 | Dementia is a major health challenge, as it is predicted to affect 100 million people by 2050. Hearing loss was recently shown to be a major risk factor for dementia. However, the biological mechanisms underlying this correlation are unknown. The neurovascular system plays a crucial role in the neurodegenerative pathop... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_4ac5b4661b7450d0d1e7ac25c0dc14f8 | The cerebrovascular system: the missing link between hearing loss and dementia? | Alzheimer's Research UK | Institut Pasteur | HRCS22_13671 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_86a474b5bc5dc91c9644ec105a616eaa | Functional and metabolomic analysis of iPSC-derived Purkinje neurons from AT patients | Ataxia-Telangiectasia Society | FIRC Institute of Molecular Oncology | HRCS22_13676 | Functional and metabolomic analysis of iPSC-derived Purkinje neurons from AT patients | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_76eb404c41ef2e6002fa0a5e13a57299 | Multicenter, randomised, placebo-controlled, double-blinded, parallel arm proof-of concept trial of Lixisenatide in patients with early Parkinson’s disease (LIXIPARK - Extension) | Cure Parkinson's | Centre Hospitalier Universitaire de Toulouse | HRCS22_13683 | Extension to WM011. Please see above. | 6.1 Pharmaceuticals | 6project_grants_public |
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