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gen_e987771e87df5ff696b4debead2c39a1 | Understanding how clonal hematopoiesis feeds lymphoma | Worldwide Cancer Research | Institute of Oncology Research | HRCS22_15962 | As the fifth most frequently occurring cancer type in humans, lymphoma still requires to be mechanistically better understood in order to achieve a satisfactory relative survival. A promising approach to close this knowledge gap concerning lymphoma consists in investigating the microenvironment and potentially occurrin... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_de1a6783eba71dee9b3619f6076e1feb | Early exposure to radio-frequency electromagnetic fields and cancer: complete evaluation of the Ramazzini Institute long-term carcinogenicity bioassays on Sprague-Dawley rats | Children with Cancer UK | Istituto Ramazzini | HRCS22_15966 | Humans in modern society are exposed to an ever-increasing number of radiofrequency electromagnetic fields (RFR). Key sources of RFR include mobile phones, wireless networks and base station antenna. Concern is expressed about possible health effects, particularly children appears to be more sensitive to RFR than adult... | No Research Activity assigned | 6project_grants_public |
gen_32649fa9a27b236ed545112a763deac1 | Biomarkers Part 2 | Duchenne UK | Duke University | HRCS22_15982 | This project will be looking at biomarkers to be used in clinical trials. | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_216a3d785370cc502f5b1dd798bb4c0f | Exploring the functional role of EZH2-dependent autocrine signaling in T-cell leukemia | Worldwide Cancer Research | Casa Sollievo della Sofferenza | HRCS22_15987 | BACKGROUND: T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is a malignancy with refractory/relapsed cases, presumably due to the ineffective targeting of leukemia initiating cells (LICs). DNA mutations, leading to the hyperactivation of Notch1 signaling, are found in >50% of human T-ALL. NOTCH1 binding induces th... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_f54ec7d406a1b5bf92bb518f137478a7 | Targeting GH signalling: a novel radiosensitising strategy | Worldwide Cancer Research | University of Auckland | HRCS22_15993 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_efac2d3960b02e7f52d7cfe480d2672c | Role of PI3K-C2G in pancreatic cancer metabolism | Worldwide Cancer Research | University of Turin | HRCS22_15995 | Pancreatic cancer (PC) is the most lethal cancer across the world, with incidence equaling mortality. Recently, PC emerged as a metabolic outlier characterized by several metabolic dependencies, representing an unmet opportunity for the development of novel therapeutic approaches. A wealth of studies report that enhanc... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_717cf461daf5404dbd6e59f3c727f716 | NUMB splicing modulation with AONs as a novel lung cancer treatment | Worldwide Cancer Research | Centre for Genomic Regulation | HRCS22_15997 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_29b67c9117ecbf97c79e003bcb62a1f8 | Identifying key amino acid metabolic steps as potential drug targets for Chagas disease treatment | Wellcome Trust | University of Sao Paulo | HRCS22_16008 | Trypanosoma cruzi, the causal agent of Chagas disease, has a complex digenetic life cycle. This organism is well adapted to handle environmental changes, presenting high metabolic flexibility. In this context, amino acids and their metabolism play crucial roles in cell differentiation, maintenance of cell volume and re... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_0c93fb3636de6edfdd63ec36359fbcd6 | Research Enrichment Funding for the Public engagement programme of CIDRI-Africa | Wellcome Trust | University of Cape Town | HRCS22_16027 | The Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa) at the University of Cape Town leads research programmes on high-burden infectious diseases, particularly HIV and tuberculosis. Through this enrichment grant, we will develop our researcher community as public engagement champions, improve ou... | 7.1 Individual care needs | 6project_grants_public |
gen_60ff6246b8b55ab2fd56a82a1c02d80f | Decoding the role of lipids in the metabolic control of CD8+ T cells by the gut microbiota to improve outcomes in colorectal cancer. | Worldwide Cancer Research | European Institute of Oncology | HRCS22_16034 | Over a third of resected early-stage colorectal cancer (CRC) relapse and patients die from metastatic disease. Infiltrating lymphocytes are independent positive predictor of survival in CRC, however only a small fraction of patients respond to immune checkpoint inhibitors (ICI). This project originates from two milesto... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_71360dbc15ca1d51bf69d731fa5a8b61 | Dissecting the molecular mechanisms that sustain frequent oncogenic BAP1 mutations | Worldwide Cancer Research | European Institute of Oncology | HRCS22_16035 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_2cacb7896490467096a363147d172390 | Investigating the roles of NF-κB subunits as master regulators of CD8+ T-cell function in cancer immunity and immunotherapy. | Worldwide Cancer Research | Cancer Center of Lyon | HRCS22_16036 | Cancer progression is greatly influenced by a delicate balance between tolerance to and immune response against tumors. The recent success of immunotherapies such as checkpoint-blockade therapies, demonstrates that this balance can be shifted effectively towards enhanced anti-tumor immunity, to delay or even stop cance... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_431da97927d45c6519c56d8db25052f7 | Identifying properties of tumour suppressive pericytes for cancer therapy (PERISUPPRESS) | Worldwide Cancer Research | CERCA Institution | HRCS22_16064 | Non-transformed co-habitant cells, defined as stroma, play key roles in the development and progression of tumours. Thus, understanding their function is instrumental for the efficacious eradication of the disease. Taking advantage of computational analyses, a unique collection of prostate cancer (PCa) mouse models, an... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_00c124ae962579836cb4cb0bb2f9d026 | ‘We are the heroin capital of Europe’: Marginal Communities, Health, Identity, and the Opioid Epidemic in Twentieth-Century Ireland | Wellcome Trust | University College Dublin | HRCS22_16079 | Keywords: Heroin, drugs, Ireland. By 1990 heroin had devastated working-class communities across Dublin and, in some families, wiped out entire generations. But how did things reach that stage when three decades previously heroin was only known in Ireland as a symbol of distant, undesirable, foreignness? This project w... | 8.1 Organisation and delivery of services | 6project_grants_public |
gen_66f98f411b2deb166b213db3216ce699 | Unravelling the requirement of Rad18 in glioblastoma proliferation | Worldwide Cancer Research | Cancer Research Center of Toulouse | HRCS22_16094 | Glioblastoma is the most frequent and aggressive primary brain tumor characterized by a strong resistance to therapy involving treatment with ionizing radiations and alkylating agents. The molecular grounds of this acquired resistance are currently unknown. The identification of novel therapeutic targets constitutes th... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_db4c505020bebfa2fb6acba203da3e18 | Impact of a Typhoid Conjugate Vaccine Campaign on Antimicrobial Use in Harare, Zimbabwe | Wellcome Trust | Biomedical Research and Training Institute | HRCS22_16112 | Typhoid fever is a common cause of non-specific febrile illness in low-resource settings. Empirical treatment for typhoid may be a major driver of AMR in typhoid-endemic communities, where estimates suggest that up to 25 additional cases receive antimicrobial treatment for each one confirmed. Harare in Zimbabwe has exp... | 3.4 Vaccines | 6project_grants_public |
gen_156df0077ff39bd9ec6e643d49f29902 | Defining NRF2-independent ROS management as bottleneck to tumor initiation | Worldwide Cancer Research | New York University | HRCS22_16120 | Cancer is generally viewed as a genetic disease, which develops when cells acquire mutations in proto-oncogenes and tumor suppressors. These mutations are thought to progressively derail tissue homeostasis, allowing for an expansion of tumorigenic clones with unlimited proliferative potential that fuels long-term tumor... | 1.1 Normal biological development and functioning | 6project_grants_public |
gen_ec4962254d6cab4c2bef16eeb33d31fb | Preclinical development of antisense oligonucleotide therapy for RIPOR2-associated adultonset hearing loss | Royal National Institute for Deaf People | Radboud University Nijmegen Medical Centre | HRCS22_16125 | We recently identified a 12-nucleotide deletion in RIPOR2 (rs760676508) as a frequent cause of dominantly inherited adult-onset sensorineural hearing loss (DFNA21). Based on the allele frequencies in gnomAD, it is estimated that ~30,000 individuals in Northwest Europe are at risk to develop hearing loss due to this RIP... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_67a2749fc72a81a51cca8712f9289f03 | Characterising the role of RET in breast cancer brain metastasis as a facilitator of colonisation and a novel targeted therapy | Breast Cancer Now | Royal College of Surgeons in Ireland | HRCS22_16127 | Brain metastasis occurs in 10-30% of breast cancer patients and is fast becoming the foremost clinical challenge in the management of metastatic disease. Limited therapeutic options exist for patients with brain metastasis and the current treatment paradigm consists of surgical resection, stereotactic radiosurgery and ... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_184fb2511af737ecc47b0160f942738d | Improved surveillance of zoonotic Mycobacteria through rapid direct detection and genotyping in livestock, wildlife, and their environment from low-resource areas in South Africa. | Wellcome Trust | Stellenbosch University | HRCS22_16129 | Recent studies in Africa and India (countries with high TB- and HIV-burdens) reported increased frequency of zoonotic tuberculosis (zTB) in humans caused by other members of the Mycobacterium tuberculosis complex (MTBC) like M. orygis, indicating that M. bovis infection may be an inadequate proxy for zTB. Similarly, no... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_689ecadafb4996278c5e4c8b07f6e97a | PPS - RTI | Duchenne UK | RTI International | HRCS22_16136 | This is a collaboration funded by Duchenne UK. It involves RTI International, Parent Project Muscular Dystrphy and Newcastle University, who are all recepients of funding based on their contribution. This collaborative project will assess and explore clinician, patient, and caregiver attitudes, priorities, and risk tol... | 7.1 Individual care needs | 6project_grants_public |
gen_3806d039adf3dd495e3f5a04aff46c97 | Determining the neuroprotective and neurorestorative efficacy of AAV-hGDF5 in the AAV-α-synuclein rat model of Parkinson’s. | Cure Parkinson's | University College Cork | HRCS22_16139 | In Europe, 1.2 million people have Parkinson’s disease (PD), with a total socioeconomic cost of €13.9 billion per annum, which will double by 2030. No current therapy stops the symptoms of PD from worsening. This project proposes that a neurotrophic factor called growth differentiation factor 5 (GDF5) can be applied as... | 5.2 Cellular and gene therapies | 6project_grants_public |
gen_567c42aca34551493d87189788a1bf64 | Notch3 as a regulator of cancer-associated fibroblast reprogramming and functions in intestinal cancer | Worldwide Cancer Research | Alexander Fleming Biomedical Sciences Research Center | HRCS22_16166 | The Notch signaling pathway plays an important role in development, homeostasis, and disease, such as cancer, where its therapeutic potential is under consideration. However, the role of individual receptors, their cell-specific functions, and their implication in cancer therapy is not yet fully understood. Notch3 is o... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_cc1c24b75904911738d57444b0766583 | Pre-clinical evaluation of lonafarnib as a treatment for Parkinson's disease | Cure Parkinson's | Northwestern University | HRCS22_16195 | Genetic and pathological evidence strongly suggests that alpha-synuclein (a-syn) accumulation and lysosomal dysfunction are major contributors to Parkinson’s disease pathogenesis. Dr Mazzulli's group recently discovered a novel mechanism for a-syn-induced toxicity and lysosomal dysfunction using patient-derived iPSC-mi... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_65734e05463318635939a86c5d427b54 | Uncovering the effects of DNA replication stress on cell fate determination in cancer and stem cells. | Worldwide Cancer Research | University of Milan | HRCS22_16200 | Several studies have indicated that most cancer cells are associated with stress caused by the perturbation of DNA replication inducing replication stress (RS). RS and in general genome instability are major causes of genetic and epigenetic heterogeneity in human tumors. However, despite this heterogeneity, tumor mass ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_ce72dcebc272d150014e00ac915d6e36 | Targeting TFEB transcription factor as a novel therapeutic approach for the treatment of Birt-Hogg-Dube’- associated kidney cancer | Worldwide Cancer Research | Telethon Institute Of Genetics And Medicine | HRCS22_16209 | Birt-Hogg-Dube’ is a hereditary cancer syndrome, due to loss of function mutations in the gene encoding Folliculin and characterized by benign skin tumors, lung and kidney cysts and renal cell carcinoma. Renal tumors represent the most severe manifestation of the disease and to date surgery is the only available therap... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_303c4bb32b2cfd131161892c09827889 | Pre-clinical evaluation of combination treatments for invasive lobular breast cancer | Worldwide Cancer Research | Royal College of Surgeons in Ireland | HRCS22_16210 | Invasive lobular carcinoma (ILC) is the second most common type of breast cancer (approximately 10-15% of all breast tumors). Women with ILC are usually older, used hormone replacement therapy and are more likely to have ER+ disease. Compared to other ER+ breast cancers, ILCs are more likely to metastasize to the perit... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_462388c127e3278955c13cf742959e02 | Understanding spontaneous loss of heterozygosity | Worldwide Cancer Research | Institute Curie | HRCS22_16214 | Using a novel model established in my team of spontaneous stem cell genome instability in fruit flies, our proposed work will address several important currently open questions about a major pathway of tumor suppressor inactivation: loss of heterozygosity via mitotic recombination. How do genomic features contribute to... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_9ab61cd6bc4a972e1cc2e12f9a8e12ff | Novel BBB penetrating peptide for the treatment of Parkinson’s disease | Cure Parkinson's | University of Helsinki | HRCS22_16255 | The prevalence of neurodegenerative diseases, such as Parkinson’s disease (PD), is growing rapidly due to an aging population. Current treatments for PD only relieve symptoms and cannot stop the progression of the disease, thus there is an urgent need for new therapies. Neurotrophic factors (NTFs) are secretory protein... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_c09925a5fe2e427501ebed470e67ec22 | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Mesotrypsin for Cancer Therapy | Worldwide Cancer Research | Ben-Gurion University of the Negev | HRCS22_16274 | Mesotrypsin is a serine protease that is upregulated with tumor progression and associated with poor prognosis in many human cancers. In cancer models, mesotrypsin promotes tumor growth, invasion, and metastasis, making it an attractive target for therapeutic intervention. To date, no selective inhibitors against mesot... | 5.1 Pharmaceuticals | 6project_grants_public |
gen_7f843d36245720da689a8b3c93783a15 | Climate adaptation and sustainable rural health outcomes in Southern Africa | Wellcome Trust | Human Sciences Research Council | HRCS22_16275 | The proposed project seeks to assess the complex health impacts of some of the major climate adaptation actions in rural Southern Africa, using case studies of Zimbabwean communities located in the mid-Zambezi Valley area, in the north of the country, along the borders with Zambia and Mozambique. The specific focus wil... | No Research Activity assigned | 6project_grants_public |
gen_0fbae4f6d98a397d5fc3677fd553d520 | Identification of novel drug targets in the Notch pathway that are relevant to tumor formation | Worldwide Cancer Research | University of Milan | HRCS22_16294 | Recent work in Drosophila melanogaster has revealed a central role of the endo-lysosomal compartment in Notch signaling activation. However, endo-lysosomal Notch signaling is ill-understood in mammals and strategies to counteract it have not emerged yet, limiting our ability to act on tumors arising from Notch signalin... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_b15f8f0b58c1a4333cb2c1c3bbd8f905 | Adoptive immunotherapy of acute Leukemia with CD1c retargeted iNKT cells | Worldwide Cancer Research | Fondazione Centro San Raffaele | HRCS22_16304 | We have shown that a group of human T lymphocytes kills acute leukemia blasts by recognizing the leukemia-associated lipid antigen methyl-lysophosphatidic acid (mLPA) presented by the CD1c molecule, which is identical in all individuals, suggesting a donor-unrestricted adoptive immunotherapy approach. Indeed, we effici... | No Research Activity assigned | 6project_grants_public |
gen_8fce168ff591389867faeccc09dbf0af | Translational Control of the Immune Response in the Tumor Microenvironment | Worldwide Cancer Research | University of Milan | HRCS22_16313 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_821844c9c3413023019c2fbde1cd63a9 | Role of the interferon system in DNA replication fork stability and chemo-resistance | Worldwide Cancer Research | University of Zurich | HRCS22_16321 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_6354f90a7d1525287b7f259fc5ee5f92 | Chromatin organization and transcription factor targeting in the establishment of oncogene-induced senescence and cancer progression. | Worldwide Cancer Research | Fondazione Centro San Raffaele | HRCS22_16334 | Background. Oncogene-induced senescence (OIS) acts as a powerful tumor suppressive mechanism by inducing quasi-irreversible cell-cycle arrest when cells experience oncogenic stress. Senescent cells, however, can still overcome OIS leading to cancer onset. Senescence is caused by persistent DNA damage and it is charact... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_db1f6fe56b4301cd9b75b3350b31dc2d | Role of the RNA helicase DDX3X in Myc-induced lymphomagenesis | Worldwide Cancer Research | European Institute of Oncology | HRCS22_16355 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_c82a4c643c1b2c1333b40f525b2c9534 | Effects of intra-uterine HIV exposure on antibody functionality and B cell development | Wellcome Trust | University of Cape Town | HRCS22_16390 | Approximately 30% of pregnant women in South Africa are HIV-infected resulting in over 300 000 infants exposed to HIV in utero every year. Rates of infectious mortality are reportedly higher among HIV-exposed uninfected infants (iHEU) compared to HIV-unexposed uninfected infants (iHUU). Studies evaluating the effects o... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_ad32ffeefe662f7e18d7cfd0d7cbc2fd | Ultra-Sensitive, Switchable MRI Reporters for Lung Metastases | Worldwide Cancer Research | German Cancer Research Center | HRCS22_16398 | Early cancer detection and visualisation of disease progression are highly relevant for succesful therapy. Imaging reporters for minimally invasive methods such as MRI are thus an indispensable component and visualising information of the biological complexity of tumour tissue beecomes increasingly important for choosi... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_d4f0807b2be3a578a274a80b945fe521 | Determinants of EML4-ALK Driven Lung Cancer Growth and Therapeutic Responses | Worldwide Cancer Research | German Cancer Research Center | HRCS22_16421 | Lung adenocarcinomas (LUAD) in non-smokers often harbour specific genetic aberrations, such as gene fusions involving the Anaplastic Lymphoma Kinase (ALK) and the echinoderm microtubule-associated protein-like 4 (EML4). This oncogenic fusion has been reported to have 15 different variants, which harbour the same ALK se... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_a2b783270e9eebd6f811c01fd8d6514f | Oncogene discovery in esophageal cancer through interrogation of 3D regulatory landscapes | Worldwide Cancer Research | Max Planck Institute for Molecular Genetics | HRCS22_16429 | Esophageal cancer is one of the most common and lethal cancers worldwide, yet currently no targeted therapeutics exists for its treatment. A critical roadblock in the development of targeted therapeutics for esophageal cancer is the lack of knowledge of the key oncogenic drivers in this cancer and the regulatory landsc... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_f03e5353734b98356503042328a9f123 | Mechanisms of resistance to anti-TGF-beta therapies in metastatic colorectal cancer | Worldwide Cancer Research | Institute for Research in Biomedicine | HRCS22_16434 | Most colorectal cancer (CRC) patients die as a result of metastasis. Neither conventional chemotherapy nor current targeted therapies offer significant benefits once the disease has spread to distant organs. Immune checkpoint inhibitors have shown efficacy in only a small subset of patients bearing hypermutated CRCs. A... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_885d690711506c6d78ca8beb6599649b | International integrated analysis to identify markers of poor survival in high-risk neuroblastoma | Solving Kids' Cancer | Vall d'Hebron Hospital Universitari | HRCS22_16441 | The outcome for patients with high-risk neuroblastoma is currently inadequate despite intensive multimodal therapy and despite continued treatment intensification (such as the addition of immunotherapy or tandem high-dose chemotherapy). To date, most patients with high-risk are treated in a broadly similar manner. Man... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_62f9927e81b95dd91c2b860fce8bff0e | Targeting CPEB-mediated translational balance in Hepatocellular Carcinoma | Worldwide Cancer Research | Institute for Research in Biomedicine | HRCS22_16442 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_d46680739a45054cad449254bbccacbe | Resolving the tumour suppressor function of the E3 ubiquitin ligase Parkin | Worldwide Cancer Research | Walter and Eliza Hall Institute of Medical Research | HRCS22_16445 | The E3 ubiquitin ligase Parkin is critical for maintaining mitochondrial quality control as it is the key effector in damage-induced mitophagy. As well as a have key role in early onset Parkinson’s disease, Parkin is emerging as an important tumour suppressor, with mounting evidence indicating that the gene encoding Pa... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_8f7aec31911494f31e59c727e2fc5756 | Harnessing immune circadian rhythms to advance anti-tumour immunotherapeutic strategies | Worldwide Cancer Research | Pompeu Fabra University | HRCS22_16446 | No abstract available for this analysis. | HRCS Research Uncodeable | 6project_grants_public |
gen_79d56275bdbb9eeaa8903942708b6eea | PRECISION - supplementary award | Cancer Research UK | Netherlands Cancer Institute | HRCS22_16455 | Background Ductal carcinoma in situ (DCIS) now represents 20-25% of all breast neoplasia. This is due to large-scale detection by widely adopted population-based breast cancer screening programs . As a result, thousands of women are confronted with DCIS each year: more than 8,000 in the UK, 2,300 in the Netherlands, an... | 2.6 Resources and infrastructure (aetiology) | 6project_grants_public |
gen_adcb7da91c067a15c348736677fb974a | How can we harness cancer mechanobiology to prevent tumour progression? | Worldwide Cancer Research | University of South Australia | HRCS22_16463 | Metastatic breast cancer is currently incurable and new methods to halt invasion and metastasis are an important unmet clinical need. Rho-ROCK signalling in tumour cells is a key arbiter of the paracrine program by which cancers shape their microenvironments. We have established using an in vivo model of mammary cancer... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_83e3dbf83ec6033207321f7963d0941e | Motorized Traffic and Risk of Childhood Leukaemia | Children with Cancer UK | University of Modena and Reggio Emilia | HRCS22_16494 | This research project aims to assess the association between exposure to chemicals emitted by motorized traffic and industry emissions and childhood leukaemia onset. Specifically, we plan to carry out measurements of motorized traffic contaminant exposure through laboratory analyses of these pollutants and their metabo... | 2.2 Factors relating to physical environment | 6project_grants_public |
gen_fc40e29d45bbda9de7c3a1ffc5772033 | Characterisation of gene-lifestyle interactions associated with obesity-related traits in African populations | Wellcome Trust | University of the Witwatersrand | HRCS22_16509 | Obesity is increasing in Africa and elsewhere, but little is known of how genetic and environmental factors interact.The proposed research has the following components: (i) discovery phase: heterogeneity of variance analysis (HEVA) to determine candidate gene-environment interacting (GEI) variants in the Human Heredita... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_3e9bfd4a7fefbdfc12d1e75ad06bfc1f | Causes and consequences of mental health challenges in autistic individuals during the transition to adulthood | MQ Mental Health Research | Karolinska Institutet Innovations (Sweden) | HRCS22_16513 | Research Questions Autistic individuals1 face profound challenges across their lives, including high rates of mental health problems. Many of these mental health problems emerge during the transition to adulthood, as illustrated in Figure 1, highlighting the critical need to understand mental health problems faced by a... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_6d17cd26acca2b5ae4e11085d917d909 | Making vital connections; exploring how desmoplasia gets on pancreatic cancer's nerves | Worldwide Cancer Research | Temple University Health System | HRCS22_16520 | Pancreatic ductal adenocarcinoma (PDAC) will soon become the second USA deadliest neoplasia. PDAC features a fibrous stroma, desmoplasia, with low blood/nutritional supply and extensive innervation (neoneurogenesis/axonogenesis) associated with poor prognosis, neuropathy and perineural invasion. The roles of cancer-ass... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_400d5632ef2530d52502b27892b96f78 | Enhancing CAR-T cell therapies for gliomas | The Brain Tumour Charity | Harvard University | HRCS22_16527 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_fe07735477a82674108f8aa1b67877e9 | Understanding the immune cell dysfunction in pediatric lymphoma | Worldwide Cancer Research | Karolinska Institutet Innovations (Sweden) | HRCS22_16528 | Lymphoma is the third most common type of cancer among children and accounts for 10-15% of all childhood cancers. Lymphoma in children and adults are divided into three main groups; Hodgkin lymphoma, B- and T-cell lymphoma. Lymphoma stems from faulty activation of B cells and, less frequently, T cells. Upon an infectio... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_eeb08da993b2c367d522457ad46a5e84 | A computational approach to identifying trans-diagnostic predictors of antidepressant response | MQ Mental Health Research | Trinity College Dublin | HRCS22_16535 | We need to develop tools that can improve the precision with which we allocate treatments in psychiatry. Current psychiatric disease classifications (DSM-5, ICD-10) ensure reliable diagnoses across clinicians, but their diagnostic categories do not allow for individual treatment predictions – for example, most patients... | 4.1 Discovery and preclinical testing of markers and technologies | 6project_grants_public |
gen_cc56e0228e76e5c2e55b1e705687218e | Understanding oncogenic transcriptional processes in synovial sarcoma | Worldwide Cancer Research | Trinity College Dublin | HRCS22_16545 | Synovial sarcoma is an often aggressive malignancy primarily effecting children and young adults. Unfortunately, these tumours often do not respond well to conventional therapeutic interventions and overall survival rates remain poor. The disease is caused by a recurrent chromosomal translocation generating a character... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_32f69f1719f5ab612e881cf48aeaacb6 | Hysteresis conveys the EMT spread to the neighborhood tumor cells and metastasis | Worldwide Cancer Research | CERCA Institution | HRCS22_16556 | Cancer metastasis is a complex process with multiple challenges that disseminated tumour cells need to overcome to form overt metastasis, yet many biological aspects of metastasis are poorly understood. One of the most studied tumour cell phenotypic changes during metastasis is the epithelial-to-mesenchymal transition ... | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_2f1105a4f7a7f4b610ef9810946661a3 | Chlomipramine derivatives to target the ubiquitin ligase NEDD4 in lung cancer | Worldwide Cancer Research | FIRC Institute of Molecular Oncology | HRCS22_16567 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_fb30e657d54aff27c027d377fabd4f11 | Antimicrobials and antimicrobial resistance (AAMR) | Wellcome Trust | University of Nottingham | HRCS22_20539 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_77d92e9a7628adb155b41e092c9daebc | Mechanisms of inflammatory disease. | Wellcome Trust | University of Birmingham | HRCS22_20629 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_5422e382c95be38e247a37f5a624a910 | Tissue Repair | Wellcome Trust | University of Edinburgh | HRCS22_20633 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_cd8822c3d8350c939513b9fdec9ed6c8 | Molecular and Cellular Basis of Infection | Wellcome Trust | Imperial College London | HRCS22_20654 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_06bcffcfaec74710d0ae9796d1f1c6ee | Cell therapies and regenerative medicine. | Wellcome Trust | King's College London | HRCS22_20670 | No abstract available for this analysis. | Missing/Incomplete | 6project_grants_public |
gen_bdb880e2e8f6a642f82387c97eace49d | BeSecAT: Blockchain-enabled Secure and Resilient Supply Networks for Advanced Therapies Medicinal Products | Innovate UK | Cardiff University | HRCS22_21294 | Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details. | Missing/Incomplete | 6project_grants_public |
gen_9ffa039131d68a566654ae5564d8294d | RespiTrain - A novel medical technology to reduce mechanical ventilation duration by 30% | Innovate UK | University of Oxford | HRCS22_21632 | no public description | Missing/Incomplete | 6project_grants_public |
gen_18b3e15d13421cd3f95b56d528b19be1 | Songbirds Music UK: Music Interaction Telepresence Robot Research Trial | Innovate UK | Songbirds Music UK Cic | HRCS22_21895 | Songbirds Music UK: Music Interaction Telepresence Robot Research Trial Songbirds Music UK (Northwest England) run an award-winning hospital musical interaction programme with children with complex healthcare needs and disabilities. SMUK will research, develop and evaluate the use of a telepresence robot as an inter... | Missing/Incomplete | 6project_grants_public |
gen_f2a39981cd68f004ddf9d995d9b06b0e | University of the West of Scotland and Kibble Education and Care Centre | Innovate UK | University of the West of Scotland | HRCS22_22045 | To develop an advanced remote health monitoring and behavioural analysis solution utilising machine vision and artificial intelligence to improve operational efficiency, enhance care provision and generate new revenue streams through commercialisation of resulting IP. | Missing/Incomplete | 6project_grants_public |
gen_b4952a1054c2399518befea36878c8d5 | Advancing Nuclear Science via Theory and Experiment | Science and Technology Facilities Council | University of Surrey | HRCS22_22487 | For a hundred years, atomic nuclei have been probed more or less exclusively by studying collisions between stable beams and stable targets. This restricted the nuclei that could be studied to just a just a small fraction of those that are thought to exist. Most of the nuclei important to making all of the elements (in... | Missing/Incomplete | 6project_grants_public |
gen_68a1d7bb73ee3a06da3b4e970fc4bc16 | Astronomy at the Open University 2017-2020 | Science and Technology Facilities Council | The Open University | HRCS22_22489 | Our research programme, Astronomy at the Open University, covers the breadth of cosmic evolution, from dark energy to the birth of planets. We do this research by observation, laboratory experiments, simulations and modelling. We use purpose-designed laboratories and instruments, and instruments on telescopes and space... | Missing/Incomplete | 6project_grants_public |
gen_c19c07c83850e499fd34db38ef8a56e6 | Demonstration of a base metal Low-temperature Catalytic converter for deNOx (LowCat Demo) | Science and Technology Facilities Council | University of Leeds | HRCS22_22491 | Poor air quality results in around 400,000 excess deaths per year in Europe. In 2017, 39 % of NOx emissions were from road transport, with a further 45 % from sectors which include combustion or chemical processing. 86 % of observations which exceed EU air quality legislation regarding ambient NO2 concentrations were m... | Missing/Incomplete | 6project_grants_public |
gen_3bf75dcbde9f25e56df6f9bc41b2dc39 | Depleted Monolithic CMOS and Ultra-fast silicon detectors for particle physics and other applications | Science and Technology Facilities Council | University of Oxford | HRCS22_22492 | Semiconductor detectors are used widely in particle physics and other applications. This thesis concentrates on the development of two types of novel detectors. LGADs Both ATLAS and CMS are planning precision timing layers outside their trackers for the HL-LHC upgrades. These will be instrumented with a type of ultra-f... | Missing/Incomplete | 6project_grants_public |
gen_fbf32aaaaf707998feb13afac4da4eb4 | Gates Foundatoin | Praedicare Inc | INV-004622 | to evaluate novel TB drug combinations in the in vitro hollow fiber system for TB to inform our understanding of efficacy and dose selection | Family Planning|Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_56f607fe7c4bfa6d3e7207ff0e998b0d | Gates Foundatoin | International Centre for Diarrhoeal Disease Research, Bangladesh | INV-016370 | to develop shelf-stable, locally-sourced, microbiome-directed, ready-to-use therapeutic foods (MD-RUTFs) for malnourished children. | Global Education / Gender Equality | 6project_grants_public | |
gen_06509a572837eaed14375c75d22622f5 | Gates Foundatoin | University of Pretoria | INV-022216 | to support novel imaging and metabolic biomarker discovery in birth asphyxia, and the use of this information for planning for future clinical trials of neuroprotective agents | Global Education / Gender Equality | 6project_grants_public | |
gen_fbef573745455f975921ccc06e3f8fb1 | Gates Foundatoin | Armauer Hansen Research Institute | INV-023730 | to introduce a novel rapid molecular method - digital droplet PCR (ddPCR) - to detect hrp2/3 gene deletions in Plasmodium falciparum in Ethiopia | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_1ebf149db621514a1313b311e72d4a9e | Gates Foundatoin | CDC Foundation | INV-024558 | to evaluate the impact of the pneumococcal conjugate vaccine introduction on pneumococcal nasopharyngeal carriage in children in Indonesia | Research and Learning Opportunities / Global Health | 6project_grants_public | |
gen_4e3ad04e214d9c4c01af4da08d599f31 | Gates Foundatoin | Brigham and Women's Hospital, Inc. | INV-025023 | to assess whether remdesivir administered in a new simplified manner can produce effective antiviral protection in people | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_bc061b28dd6d4637c40d0d9efa16bda6 | Gates Foundatoin | Vector Borne and NTD Division | INV-026449 | to increase MDA coverage through the use of "infotainment" , an effort to modernize delivery and retention of NTD messages with a focus on reaching young populations. | Development of Solutions to Improve Global Health|Malaria / Global Health | 6project_grants_public | |
gen_3423ae516988709745a703082b2f62d8 | Gates Foundatoin | FIOCRUZ | INV-027961 | to fund 12 Ki GCE Brazil-based data science projects that advance and strengthen maternal and child health, women’s health and nutrition efforts, by using administrative data to develop better evidence and insights for policymakers | Tuberculosis / Global Health | 6project_grants_public | |
gen_223d7c23388cbdd213afbfe1d0264155 | Gates Foundatoin | Faecal Sludge Management Alliance | INV-033458 | to build capacity of professionals from low and middle income countries in non-sewered sanitation | Discovery and Translational Sciences / Global Growth & Opportunity | 6project_grants_public | |
gen_5ebd078d3783804bb61d37a120280ac6 | Gates Foundatoin | Mastory | INV-028468 | to support development of novel resources to accelerate student mastery of algebra | Research and Learning Opportunities / U.S. Program | 6project_grants_public | |
gen_d9593cf830c177e08996364bc99ed695 | Gates Foundatoin | Johns Hopkins University | INV-028582 | to guide future programs seeking to improve the nutrition of young women prior to pregnancy in South Asia and elsewhere | Pneumonia & Pandemic Preparedness / Gender Equality | 6project_grants_public | |
gen_a9fb47f67dca8e94a54df3bf846fa2fc | Gates Foundatoin | Calibr-Skaggs Institute for Innovative Medicines | INV-028691 | to deliver a drug candidate to treat coronavirus diseases | Maternal, Newborn, Child Nutrition and Health / Global Health | 6project_grants_public | |
gen_69eea08e19d42556981d74cdd6392c34 | Gates Foundatoin | The Pirbright Institute | INV-028944 | to support foot-and-mouth disease control in India | Global Health and Development Public Awareness and Analysis / Global Growth & Opportunity | 6project_grants_public | |
gen_82eb347c241583344d90f11ff8f1e2fa | Gates Foundatoin | The Center for Disease Dynamics, Economics & Policy, Inc. | INV-029062 | to contribute to improved understanding of the epidemiology of COVID-19 in India | Community Engagement Grantmaking / Global Development | 6project_grants_public | |
gen_2bee1c228d3e58d4b9c9e81fd0a8b297 | Gates Foundatoin | WeRobotics | INV-029257 | to determine whether cargo drones can enable more rapid and reliable diagnosis of children who may have polio | AFRICA|ASIA / Global Development | 6project_grants_public | |
gen_eed79f8ee66de21e81de5efa943f1217 | Gates Foundatoin | CARE | INV-029674 | to support rigorous costing and additional analysis of a multisectoral model to support married adolescent girls to delay their first birth and achieve their desired fertility intentions in Niger and Bangladesh | Vaccine Development / Gender Equality | 6project_grants_public | |
gen_57038fff9103244ad48085a830fc19dc | SHared automation Operating models for Worldwide adoption | European Commission | Gruppo Torinese Trasporti S.P.A.; KAPSCH TrafficCom AG; IRIZAR E-MOBILITY SL | CORDIS-875530 | SHOW aims to support the migration path towards affective and persuasive sustainable urban transport, through technical solutions, business models and priority scenarios for impact assessment, by deploying shared, connected, cooperative, electrified fleets of autonomous vehicles in coordinated Public Transport (PT), De... | H2020-EU.3.4. / 3.4 Societal Challenges - Transport | 6project_grants_public |
gen_fed90038b75edec8fc10e21613e8f2e0 | Gates Foundatoin | PATH | INV-030072 | to better understand the risks and external costs of the COVID-19 vaccine rollout | Development of Solutions to Improve Global Health / Global Development | 6project_grants_public | |
gen_e7d47b7daa37603eb8ac80755102f210 | Gates Foundatoin | University of California, Los Angeles | INV-028840 | to support development of novel resources to accelerate student mastery of algebra | Washington State Education and Human Service Needs / U.S. Program | 6project_grants_public | |
gen_a2c75bd607eccc213f9b48577cf6e8f1 | Gates Foundatoin | University of Notre Dame | INV-005898 | to introduce a novel rapid molecular method - digital droplet PCR (ddPCR) - to detect hrp2/3 gene deletions in Plasmodium falciparum in Ethiopia | Postsecondary Education / Global Health | 6project_grants_public | |
gen_44e73cb6b9c2082dae5f6e27c6f918ad | Gates Foundatoin | Penn State | INV-016091 | to develop novel approaches and methodologies to integrate multiple data sources to evaluate and communicate measles risk and inform programmatic decision-making at the national and sub-national level | Vaccine Delivery / Global Development | 6project_grants_public | |
gen_1652d9f30ed2ddbce2aa3db90917ae92 | Gates Foundatoin | Indian Institute of Science | INV-024649 | to develop subunit-based immunogens to the newly emerged Coronavirus as candidate vaccines | Global Health and Development Public Awareness and Analysis / Global Development | 6project_grants_public | |
gen_02a213796cdfd133278016cf39d6ee3d | Gates Foundatoin | Addis Ababa University - Center for Innovative Drug Development and Therapeutic Trials for Africa | INV-024950 | to train clinical trial coordinators to manage trials and support the operations at sites in Africa | Tuberculosis / Global Health | 6project_grants_public | |
gen_ddf3bfcc255f568767acdfa84ac22b89 | Gates Foundatoin | Lgenia Inc. | INV-025337 | to contribute to the generation of new tuberculosis drug candidates | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_4a400b3a378f85fa5f7d9e7cc93d956a | Gates Foundatoin | Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences | INV-025841 | to design and engineering of a synthetic enzyme pathway from AA to Artemisinin | Vaccine Development / Global Health | 6project_grants_public | |
gen_f98323c56980293f20721163dee43659 | Gates Foundatoin | Wuhan University | INV-026361 | to provide scientific evidence to policy makers to lower the price and improve multi-financing policies of TB drugs that lead to improved accessibilities of high quality TB services and reduced financial burden for TB patients | K-12 Education / Global Policy and Advocacy | 6project_grants_public | |
gen_45f54edc4de882bb6a91f7ecdd400b96 | Gates Foundatoin | Indian Institute of Technology Delhi | INV-027027 | to accelerate COVID19 vaccine distribution in India by Ministry of Health and Family Welfare | Polio / Global Development | 6project_grants_public | |
gen_40d5a80a167c5beb7bef30cac65fa5e4 | Gates Foundatoin | Shanghai Jiao Tong University | INV-027291 | To improve global market need for antimalaria treatment supply of artemisinin. | K-12 Education / Global Health | 6project_grants_public | |
gen_24dfc889761445b43ffc0512be94ffab | Gates Foundatoin | The School Board of Broward County, Florida | INV-028815 | to support development of novel resources to accelerate student mastery of algebra | Inclusive Financial Systems / U.S. Program | 6project_grants_public |
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