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|---|---|---|---|---|---|---|---|
gen_2f5344d64aa2c9237b59ae4a3c2adc43 | Gates Foundatoin | University of Florida | INV-028844 | to support development of novel resources to accelerate student mastery of algebra | K-12 Education / U.S. Program | 6project_grants_public | |
gen_a3a15549144c9e9590e3a8c33c4eef4f | Gates Foundatoin | TB Alliance | INV-004641 | to discover and develop improved TB drug regimens effective against all forms of TB that are shorter, simpler, and safer | HIV / Global Health | 6project_grants_public | |
gen_f35716ec516687737d57c1a6e1ee8db1 | Gates Foundatoin | University of Washington Foundation | INV-004743 | to co-fund the clinical development program of Islatravir for HIV prevention, specifically for the IMPOWER phase 3 efficacy and safety trial among women and adolescent girls in sub-Saharan Africa | Empower Women and Girls|Global Health and Development Public Awareness and Analysis|Polio|Vaccine Delivery / Global Health | 6project_grants_public | |
gen_f0b6c049c116a32c3b39d41393504522 | Gates Foundatoin | Clinton Health Access Initiative Inc | INV-006419 | to landscape diagnostic needs and opportunities of Burkina Faso and Mali. | Enterics, Diagnostics, Genomics & Epidemiology|Global Health and Development Public Awareness and Analysis|Maternal, Newborn, Child Nutrition and Health|Nutrition|Pneumonia & Pandemic Preparedness|Vaccine Delivery / Global Development | 6project_grants_public | |
gen_74bfe01278042bfa9bc17682c5f6a645 | Gates Foundatoin | Fundação Manhiça | INV-019032 | to develop malaria genomic epidemiology capacity in Mozambique order to inform programatic decisions to eliminate malaria | Water, Sanitation and Hygiene / Global Health | 6project_grants_public | |
gen_1cf585ac6498bde6f60558c8ec799bad | Gates Foundatoin | University of California San Francisco | INV-024346 | to support countries to tailor malaria intervention strategies through use of innovative entomological, high-risk population, and molecular surveillance methods | Public Awareness and Knowledge Sharing / Global Health | 6project_grants_public | |
gen_c95ae4a3a7553c006e46a78b53a864ef | Gates Foundatoin | Hilleman Laboratories Singapore Pte Ltd | INV-002058 | to develop alternative host for lower cost production of key protein used for production of vital vaccines | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_7456073f9ee7dc653f83745a4a730444 | Gates Foundatoin | Oxitec | INV-025721 | to assess the feasibility of a self-limiting R microplus for sustainable tick control | Global Health and Development Public Awareness and Analysis / Global Growth & Opportunity | 6project_grants_public | |
gen_3133b9e6ce67af27d90713f6970844c4 | Gates Foundatoin | The William Davidson Institute at the University of Michigan | INV-026701 | to fund deployment of a previously developed tool to support patient flow analysis to support smooth operation of primary healthcare services during and post Covid-19 | Neglected Tropical Diseases / Global Development | 6project_grants_public | |
gen_ecf7a53b27379bcd7dc1d6a4039957e0 | Gates Foundatoin | NALA Foundation | INV-026720 | to better equip endemic countries in Africa to eliminate morbidities caused by soil-transmitted-helminths through water, sanitation, and hygeine program integration. | Create Novel Technology Platform Capabilities / Global Health | 6project_grants_public | |
gen_5fc0efda28909d5578640928edcef3e2 | Gates Foundatoin | Helix Nanotechnologies Inc | INV-026743 | to develop synthetic immune synapses to trigger rapid and long-lasting immunity against global health pathogens | HIV / Global Health | 6project_grants_public | |
gen_6226cab619df2c614243708dbc93f773 | Gates Foundatoin | Texas Tech University Health Sciences Center | INV-027122 | to develop a functional assay of enzymatic activity to serve as a surrogate for protection of the schistosomiasis vaccine | K-12 Education / Global Health | 6project_grants_public | |
gen_c0422076e9f2086c26aa4a71d3850412 | Gates Foundatoin | University of Oxford | INV-027520 | to identify monoclonal antibodies, against pre-erythrocytic merozoite targets, which prevent plasmodium falciparum infection | HIV / Global Health | 6project_grants_public | |
gen_5df0fcd031945f17347115dff858a467 | Gates Foundatoin | Johns Hopkins University Bloomberg School of Public Health | INV-028023 | to develop co-variate adjustment statistical methods and open-source, validated software to improve the efficiency and outcomes of randomized clinical trials | Agricultural Development / Global Health | 6project_grants_public | |
gen_086394ca612ecb5d2e4aa50f5c8cb259 | Gates Foundatoin | Virginia Commonwealth University | INV-029019 | to identify alternative drug formulation and manufacturing methods for a novel, inhalational synthetic surfactant for treatment of infants with Respiratory Distress Syndrome | Development of Solutions to Improve Global Health / Gender Equality | 6project_grants_public | |
gen_d38c29f91da9288994005a22715a4967 | Gates Foundatoin | International Vaccine Institute | INV-029131 | to support the development of International Vaccine Institute's 2021 - 2026 global health impact strategic plan | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_4e5c591e98bfbc3d564c18d038f3dbb9 | Gates Foundatoin | BlueSquare | INV-029666 | to improve timeliness and effectiveness of Polio Outbreak responses through strengthened systems for data integration and use | Vaccine Delivery / Global Development | 6project_grants_public | |
gen_848d6d6b43a8253a1a719039b2e570b5 | Gates Foundatoin | PATH | INV-029679 | to monitor the syringe market and inform key decisions to stabilize routine immunization syringe capacity for low and middle income countries | Inclusive Financial Systems|Polio / Global Development | 6project_grants_public | |
gen_c257fe846b2589c6caf016b8086f13c1 | Gates Foundatoin | World Health Organization Pakistan Country Office | INV-030215 | to interrupt wild poliovirus transmission in Pakistan | Vaccine Development / Global Development | 6project_grants_public | |
gen_435b312c3b9295339ff71534ec5c2452 | Gates Foundatoin | Instituto D'OR de Pesquisa e Ensino | INV-030336 | to improve durability, efficacy and deliverability of COVID-19 vaccines | Postsecondary Education / Global Health | 6project_grants_public | |
gen_47b99446cc136a2c2ad97a0d50824cd1 | Gates Foundatoin | World Health Organization | INV-030439 | to end the circulation of vaccine-derived polioviruses through timely and quality vaccination campaigns within six months of detection of cVDPVs | Malaria / Global Development | 6project_grants_public | |
gen_27c35a8e3328249599d1e6e5d33d3a29 | Gates Foundatoin | Swiss Tropical & Public Health Institute | INV-030449 | to calibrate country-specific models; this investment will build on a previous one-year pilot to scale up work with country programs, largely through WHO's High Burden, High Impact program | Maternal, Newborn, Child Nutrition and Health / Global Health | 6project_grants_public | |
gen_8ea9427a11eb0bcfc88d37504531205d | Gates Foundatoin | JSI Research & Training Institute, Inc. | INV-030665 | to provide technical assistance to the Government of India for completing national scale-up of pneumococcal conjugate vaccine in India | K-12 Education / Global Development|Global Health | 6project_grants_public | |
gen_ac6684f125ea4220beae527adf278244 | Invasive plant species and the farming sector in Ireland | Irish Research Council | Institute of Technology, Sligo | Not available | Early Career / Employment-Based Programme | 6project_grants_public | |
gen_e66e9a14bf4e0ce08475d64afdb3f836 | IMAXT : imaging and molecular annotation of xenografts and tumors | Cancer Research UK | Memorial Sloan Kettering Cancer Center | HRCS22_14116 | We propose to develop an entirely new way for scientists and physicians to understand cancer and predict its clinical behaviour. Our integrated approach will produce faithful three-dimensional representations of tumours and their host environments, wherein each cell is identified and molecularly annotated. These models will be presented in an interactive, virtual reality (VR) framework. Investigators will literally be able to walk inside a tumour, visualize the arrangement of tumour cells in relation to each environmental cell type, and perform interactive comparative molecular analyses in real time. We call this project IMAXT, Imaging and Molecular Annotation of Xenografts and Tumours. This approach harnesses our innate pattern recognition capabilities while maintaining the statistical rigour of molecular measurements. We wish not only to provide research tools that allow us to better understand how cancer develops and responds to therapy but also to transform the way that patients are diagnosed and treatments planned. Though this approach will be applicable to nearly all tumour types, we will begin in breast cancer, where both inter- and intra-individual heterogeneity are apparent and inform treatment decisions and prognosis. | 2.1 Biological and endogenous factors | 6project_grants_public |
gen_7f8a7da443334cf8d2810de65b78215a | Gates Foundatoin | Advanced Education Research & Development Fund | INV-001159 | to conduct a portfolio of bold education R&D programs that fund and direct the work of teams of researchers, developers, and practitioners to demonstrate a breakthrough approach to an important K-12 education challenge. | Family Planning / U.S. Program | 6project_grants_public | |
gen_bd4331c2ffd7e6e6f00c780aea767ac0 | Gates Foundatoin | National Institute for Communicable Diseases (NICD) - South Africa | INV-031512 | to assist malaria elimination efforts in South Africa by integrating a genomic surveillance platform into the existing routine malaria surveillance program to better identify the source of malaria infections and track parasite spread | Malaria / Global Health | 6project_grants_public | |
gen_96b40b3247cf845b80ab5bfdb4dbb48e | Gates Foundatoin | Infectious Diseases Research Collaboration | INV-031515 | to better track the spread of malaria in Uganda by integrating a molecular surveillance system into their national control program that can identify a currently under-detected variant of the causative parasite Plasmodium falciparum | Vaccine Development / Global Health | 6project_grants_public | |
gen_b0fce35585e403da1fe26c1c1fef5b2c | URBiNAT - Healthy corridors as drivers of social housing neighbourhoods for the co-creation of social, environmental and marketable NBS | European Commission | NEW GROWING SYSTEMS SL; ASSOCIACAO BIOPOLIS; UNIVERSITET PO ARCHITEKTURA STROITELSTVO I GEODEZIJA | CORDIS-776783 | URBiNAT focuses on the regeneration and integration of deprived social housing urban developments through an innovative and inclusive catalogue of Nature-Based Solutions (NBS), ensuring sustainability and mobilising driving forces for social cohesion. Interventions focus on the public space to co-create with citizens new urban, social and nature-based relations within and between different neighbourhoods. Taking the full physical, mental and social well-being of citizens as its main goal, URBiNAT aims to co-plan a healthy corridor as an innovative and flexible NBS, which itself integrates a large number of micro NBS emerging from community-driven design processes. URBiNAT consists of a worldwide consortium of academic and business partners around 7 European cities (Porto, Nantes and Sofia as ‘frontrunners’; Siena, Nova Gorica, Brussels and Høje-Taastrup as followers), that will act as living laboratories to implement healthy corridor solutions. The cities will be supported by local partners, associations and research centres, and by Europe-wide centres, universities and companies. These will develop a participatory process, an NBS catalogue and a healthy corridor, while monitoring impacts, disseminating and marketing results. Together, they form an inclusive community of practice (CoP), collaborating with partners from Iran and China, and NBS observers located in Brazil, Oman, Japan and a Chinese city, bringing experiences and an international dimension to the project. Partners will contribute their innovative NBS experience deployed through an array of transdisciplinary knowledge, methodologies and tools, as nature-based solutions. This will be supplmented by ‘smart’ digital tools, citizen engagement, solidarity and social economy initiatives, social innovation for value-generation, incubation for business development and capacity building, and ICT governance platforms. The social, economic and urban impacts will be measured and replicated by URBiNAT Observatory. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 3networking_collaborative |
gen_805cd64213744b64f17d12f5495467b3 | Gates Foundatoin | Centre for Science and Environment | INV-015819 | to provide independent measurement of fecal sludge treatment capacity, utilization, and environmental impact | AFRICA / Global Development|Global Growth & Opportunity | 6project_grants_public | |
gen_7089deb23d23c98fc44ff2983f42e560 | Gates Foundatoin | PATH | INV-024428 | to examine primary health care (PHC) cold chain equipment (CCE) needs holistically, and identify lessons from immunization CCE maintenance for broader PHC equipment maintenance | Discovery and Translational Sciences|Global Health and Development Public Awareness and Analysis|Vaccine Development / Global Development | 6project_grants_public | |
gen_d0fbd62ba995f4bc4545c65c389902eb | Gates Foundatoin | Christian Medical College Vellore | INV-024915 | To investigate Covid re-infection rates and immune correlates of disease | Maternal, Newborn, Child Nutrition and Health / Global Development|Global Health | 6project_grants_public | |
gen_e94844a326fc98270c9ade12688a274e | Gates Foundatoin | University of Washington Foundation | INV-025397 | to support microsimulation modeling of MNCH and nutrition interventions | Discovery and Translational Sciences|Tuberculosis / Gender Equality | 6project_grants_public | |
gen_216e9889d7e2cacb2ddd9b4265e67875 | Gates Foundatoin | Seattle Children's Hospital | INV-026296 | to develop improved models for testing of TB vaccine candidates that will be predictive of human vaccine protective efficacy and help accelerate development of safe, effective, affordable TB vaccines | Vaccine Delivery / Global Health | 6project_grants_public | |
gen_bdd04b0c1617129d619f303fe1b20c31 | Gates Foundatoin | University of Kansas Center for Research, Inc. | INV-027417 | to provide formulations research expertise to leading CoV2 vaccines ahead of advanced preclinical and clinical studies | HIV / Global Health | 6project_grants_public | |
gen_58106ec825556a1bf29fe83c2d03749b | Gates Foundatoin | The General Hospital Corporation d/b/a Massachusetts General Hospital | INV-029123 | to understand the burden of HPV and Syphilis in women | Enterics, Diagnostics, Genomics & Epidemiology / Gender Equality|Global Health | 6project_grants_public | |
gen_e7d233b513522ff47e8537d1b208d2c8 | Gates Foundatoin | International Centre for Diarrhoeal Disease Research, Bangladesh | INV-029234 | to understand the persistence of Hepatitis E vaccine-induced antibody responses 2-3 years after the last dose | Postsecondary Education / Global Health | 6project_grants_public | |
gen_51f4af240c50703fcad6e3437bf1c1be | Gates Foundatoin | California Institute of Technology | INV-030223 | to complete the development of a fast, cost, effective diagnostic system that will enable rapid quantification of SARS-CoV-2 pathogens in environmental samples, through analysis at the point of sampling | Postsecondary Education / Global Growth & Opportunity | 6project_grants_public | |
gen_185200c3543ccacda4e9d638bc1e4961 | Gates Foundatoin | University of Maryland, Baltimore | INV-030705 | to develop an animal model of Klebsiella pneumoniae neonatal sepsis | Global Health and Development Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_b39e92e7afa201e76aa9a72b5871551d | Gates Foundatoin | Quantigen LLC | INV-028115 | to develop an alternative methods for TB specimen collection testing that will be simpler and cheaper to use, benefiting LMICs, and may be successful in detecting TB in patients for whom specimen collection is a challenge | Washington State Education and Human Service Needs / Global Health | 6project_grants_public | |
gen_879ff1c7b82ad8e6ad774aa04b9be5f7 | Gates Foundatoin | Uganda Virus Research Institute | INV-031335 | to develop a relational database to automate the analysis of routine HIV sequence data to detect potential HIV outbreaks. | Development of Solutions to Improve Global Health|Research and Learning Opportunities / Global Health | 6project_grants_public | |
gen_2ce90713d616d684c95e2a4c02e0739a | Gates Foundatoin | University of Michigan | INV-032019 | to identify broad-spectrum antiviral drugs that trigger an innate immune response and could be used against a range of viruses such as SARS-CoV by using a computational approach to analyze drug repurposing libraries | K-12 Education / Global Health | 6project_grants_public | |
gen_16c0fa219536b703f44f2da112282085 | Gates Foundatoin | University of Washington Foundation | INV-032481 | to provide additional data analysis for the Goalkeepers 2021 data report | Postsecondary Education / Communications | 6project_grants_public | |
gen_38713a8adc88b5f7da2f65b8535d68bf | Post-transcriptional Regulatory Networks | NIH | SLOAN-KETTERING INST CAN RESEARCH | 1R01HG013328-01A1 | RNA-binding proteins (RBPs) play key roles in RNA splicing, editing, nuclear export, translation, turnover, and subcellular localization. Reflecting their importance, RBPs and their cis-regulatory elements (CREs) have broad implications in human health: mutations in RBPs or CREs have well-established roles in cancer, developmental defects, particularly in neural development, and in neural degenerative diseases. Using a combination of a high-throughput, in-vitro-selection-based RNA binding assay, RNAcompete, and machine learning (ML) models trained to map from an RBP’s protein sequence to its RNA binding preferences, this project will endeavor to assign RNA sequence- and structural-context binding preferences to all human RBPs, all vertebrate RBPs, and the vast majority of metazoan RBPs. These specificities will then be used to detect and assign function to RBPs and cis-regulatory elements (CREs) in human genomes, as well as those of other model organisms. The specificities, machine learning models, and predicted CREs will be distributed widely via publication, open-source software, and user-friendly web tools like cisBP-RNA. This project has the potential to transform cancer and human genetics research supporting the estimation of the functional impact of germline or somatic mutations on post-transcriptional regulation (PTR). By improving the reconstruction of PTR networks, this project will speed research in this emerging field toward a complete understanding of this key process. This project will also permit the study of the evolution of PTR by developing tools to reconstruct PTR networks in other organisms based solely on genomic and transcriptomic data. RNAcompete will be used to assess the RNA sequence-binding preferences of the 511 still-uncharacterized RBPs in humans and D. rerio (zebrafish), thereby establishing a complete catalog of binding preferences for all likely sequence-specific RBPs in these two species. These data will be combined with binding data for >500 other RBPs from a variety of sources and used to train an ML model that reconstructs RNA-binding preferences given RBP protein sequences. These models will also leverage recent advances in de novo prediction of protein structure from sequence. RBPs will be assigned roles in PTR based on (i) the location and conservation, in human transcripts of their predicted target CREs, (ii) the correlation of their expression with the PTR fate of their putative target transcripts, and (iii) other, more powerful regression methods like the Inferelator. CRE predictions will be continuously improved using in vivo data to recalibrate in vitro motif models and to improve in silico predictions of transcript RNA secondary structure. Our predicted CREs and reconstructed PTR networks will be validated by comparisons with in vivo data collected by our team and others. Project Narrative This project combines large-scale, biochemical assays with artificial intelligence techniques to determine the vocabulary of the instructions used by our cells to determine which genes are active under which conditions. Discovering the words (called motifs) of this vocabulary will help scientists to understand which mutations change these instructions and how these changes lead to cancer and other human diseases. As new motifs are uncovered, the sequences of human messenger RNAs will be scanned to try to assign meaning to the motif vocabulary. | Non-SBIR/STTR | 6project_grants_public |
gen_f9276bc7c3536f05bc1fd6d47da2580c | Gates Foundatoin | Texas Tech University Health Sciences Center | INV-004809 | to reduce the global burden and morbidity from schistosomiasis | Polio / Global Health | 6project_grants_public | |
gen_08f10f61af8453f046fdd59f7e9e4935 | Gates Foundatoin | Viamo PBC | INV-015732 | to improve health seeking behaviors including immunization in hard to reach Union Councils in Quetta and Killa Abdullah in Pakistan through mobile phone-based approaches | Enterics, Diagnostics, Genomics & Epidemiology|Neglected Tropical Diseases|Vaccine Delivery / Global Development | 6project_grants_public | |
gen_41b49a2c68588e5b7089ed02330bd8e3 | Gates Foundatoin | Results for Development Institute, Inc. | INV-015797 | to improve the applicability and uptake of modeling and analytical results, and to identify changes to funding approaches, organizational structures, and policies that may enable better knowledge-to-policy or -program translation | Vaccine Development / Global Development|Global Health | 6project_grants_public | |
gen_6ef041e684ee77412ccd1776bed5c2b6 | Gates Foundatoin | University of Dundee | INV-026519 | to discover new lead compounds for potential treatment of TB and malaria which disproportionally afflicting the people in low and middle income countries | Create Novel Technology Platform Capabilities / Global Health | 6project_grants_public | |
gen_d7f95cf32de2bf96439c0afb40491ddd | Gates Foundatoin | Colorado State University | INV-026740 | to evaluate the potential of cell penetrating peptides to target TB. | Development of Solutions to Improve Global Health / Global Health | 6project_grants_public | |
gen_0e39321d040b8635bc503d4af23e2c2d | Gates Foundatoin | Council for Scientific and Industrial Research (South Africa) | INV-028304 | to identify pharmacoepidemiologic linkages to adverse drug reactions in the African population | Polio / Global Health | 6project_grants_public | |
gen_ecb939f2de46102cae8ec18f41cfe971 | Gates Foundatoin | University of Washington Foundation | INV-027674 | to develop injectable polymer-drug conjugage depot systems for long-acting drug delivery | Water, Sanitation and Hygiene / Global Health | 6project_grants_public | |
gen_39844639a1843e594d04adb77fdbbec9 | Gates Foundatoin | Emory University | INV-028795 | to provide core project support to FFI to enable their continued advancement of cereal grain fortification in strategic geographies. | Public Awareness and Analysis / Global Growth & Opportunity | 6project_grants_public | |
gen_dcc6ad5b7ba731398bb916b13948bf50 | Gates Foundatoin | International Vaccine Institute | INV-029227 | To enhance the impact of the Schistosomiasis vaccine project by applying rigorous research methods for study design, analysis and communication to a Ph 1b-2a study plan | Postsecondary Education|Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_876eac6cdfb934ce0f3c902ce7438c4d | Gates Foundatoin | The Pirbright Institute | INV-029761 | develop novel vaccines for foot-and-mouth disease virus in cattle | Empower Women and Girls / Global Growth & Opportunity | 6project_grants_public | |
gen_74ed00d4c849073cc852a8c59572bf48 | Gates Foundatoin | Emory University | INV-030129 | to understand and address the role of structural racism and discrimination in maternal and infant health disparities, with a focus on the southeastern state of Georgia | Discovery and Translational Sciences / Gender Equality | 6project_grants_public | |
gen_dadd80b9c659e1ae86433244d52f03fa | Gates Foundatoin | University of North Carolina at Chapel Hill | INV-030330 | to identify potent escape-resistant human monoclonal antibodies that prevent COVID-19 for use in low and middle-income countries | Public Awareness and Analysis / Global Health | 6project_grants_public | |
gen_5cb1504fdc043635e492000d12b8026c | Gates Foundatoin | Cardiff University | INV-031379 | to provide safe, low-cost, reusable menstrual products by developing a self-cleaning material impregnated with a biocidal compound, which transforms sunlight into reactive oxygen species that kill bacteria and degrade blood and odors | K-12 Education / Global Health | 6project_grants_public | |
gen_b7ae963ee75db1cf84fd11eec67673ff | Gates Foundatoin | University of Michigan | INV-031381 | to produce reusable sanitary pads that can be cleaned without water by using a hydrophobic material containing carbon nanofibers to clot the blood and microfolds that trap it in small pockets, which can be emptied by stretching the material | K-12 Education / Global Health | 6project_grants_public | |
gen_0a18943e346d8817b7e662d454afa270 | Neurotrophins and Hippocampal Plasticity: Mechanisms of Signal Transduction | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Basic Research Grant Scheme | 6project_grants_public | |
gen_a5f01060c39666569e32427d2d3d1944 | OG(H)AM: Harnessing digital technologies to transform understanding of ogham writing, from the 4th century to the 21st | Irish Research Council | Maynooth University | Not available | Principal Investigator-led / UK-Ireland Collaboration in the Digital Humanities Research Grants | 6project_grants_public | |
gen_cf2eaa84aa75eb23c981fd4f67d06eae | FIT-MIRS as Potential Therapeutics for Muscle Wasting | Irish Research Council | University of Galway | Not available | Principal Investigator-led / Starting Laureate | 6project_grants_public | |
gen_507cfe7dfda92e9cb4f7b8099961f786 | Identifying and Implementing Best Practice Crowdsourcing and Crowdfunding Strategies for Public Funded Research | Irish Research Council | University of Galway | Not available | Principal Investigator-led / Research Project Grants Awards | 6project_grants_public | |
gen_f9db335df1a31516aa4089fe5f15e8df | Crisis Coping for Marginalised Youth: Living and Learning through COVID-19 | Irish Research Council | University of Galway | Not available | Principal Investigator-led / Rapid Response Call - COVID 19 | 6project_grants_public | |
gen_a77ed6b60cb62a71ba7c7a5802f160c1 | Linking natural hazard vulnerabilities and poor sustainable development outcomes: A comprehensive analysis of disaster risk reduction legal frameworks and practices in Africa and their impact on the realisation of the sustainable development Goals in Africa. | Irish Research Council | University College Cork | Not available | Early Career / CAROLINE | 6project_grants_public | |
gen_9d2f7110fffa77c0022efffbe3c37c0d | Irish Droughts: Environmental and Cultural Memories of a Neglected Hazard | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / COALESCE Research Fund | 6project_grants_public | |
gen_80ff621ff671593b92ad151a76d1297c | Development of Reinforced biodegradable polymers for application as a cardiac stent | Irish Research Council | University College Dublin | Not available | Early Career / Employment-Based Programme | 6project_grants_public | |
gen_bc53a004e9ffe2b3d5d2e6f1d385ebba | Online Biography of Overseas Publications on Irish History including the Irish Diaspora | Irish Research Council | Maynooth University | Not available | Principal Investigator-led / Thematic Research Projects Grant | 6project_grants_public | |
gen_df066773318f05632fc4e939d30b6bc8 | An Analysis of the Impact of the European Moetary Union on Irish Macroeconomic Policy | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Thematic Research Projects Grant | 6project_grants_public | |
gen_2f3d0e6cb12f9a5e71e68b7ed25130fe | Investigating the Implications of Technological Change for Privacy Expectations and Policy | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Collaborative Research Project Awards | 6project_grants_public | |
gen_396aa2e842b3a078b8ebe1c741a439df | Developing a Process for the Empowerment of Tourism Stakeholders: to implement the DIT-ACHIEV Model for Sustainable Tourism Management in a City Location | Irish Research Council | Technological University Dublin | Not available | Principal Investigator-led / Research Development Initiative | 6project_grants_public | |
gen_3d511d8bf9e6c120adc81e8235dcaa63 | Surpass: how shared autonomous cars will transform cities | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / New Horizons | 6project_grants_public | |
gen_98d534016caa81acd3943dd7554e0b82 | Trauma-informed care and Positive Behaviour Support in Adverse Childhood Experiences | Irish Research Council | Dublin City University | Not available | Principal Investigator-led / New Foundations | 6project_grants_public | |
gen_cf6f2be35530160f26af36debd1bd911 | The Effects of Education and Training on Cultural Intelligence: Helping Europe Meet the Challenges of a Multicultural Workforce | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Research Development Initiative | 6project_grants_public | |
gen_7c422bbd0a58e7dedcc222900adeebf3 | John Henry Newman: Global and Local Theologian: Retrieving Newman's Theology to Address Contemporary Questions with a Particular Emphasis on the Dublin Writings | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Project Grants in Theology and Religious Studies | 6project_grants_public | |
gen_b6cb2df0619451970577fe64ba020524 | Comparing Third Sector Lobbies in the Developmental Welfare State: A Participatory Policy Analysis of Institutional Contexts and Decision Making Strategies across the Life Cycle | Irish Research Council | University of Galway | Not available | Principal Investigator-led / Research Development Initiative | 6project_grants_public | |
gen_f453af183fec400c643dbc113ef1e327 | Playing Social Roulette: The Impact of Problem Gambling on Individuals and Society in Ireland | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Research Project Grants Awards | 6project_grants_public | |
gen_a3a280a6d0b0dec021e0b895876b6d06 | Investigating Cortical and Subcortical Interactions during Sustained Attention | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Consolidator Laureate | 6project_grants_public | |
gen_7a8de0bc7332c362f1f59308443ef8d6 | Tracing Diatopic Variation in a Corpus of Old Irish | Irish Research Council | Maynooth University | Not available | Principal Investigator-led / Advanced Laureate | 6project_grants_public | |
gen_e18083cad5d4c4389fb7403f59bbc52b | Applying deep learning methods to enrich engineering simulations of advanced manufacturing processes | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Starting Laureate | 6project_grants_public | |
gen_e474e49f9466b7badc6d4ce8d1a7f5ce | ENVIRST – the development of a brief screening tool for the assessment of environmental risk factors in mental health and well-being | Irish Research Council | RCSI University of Medicine and Health Sciences | Not available | Principal Investigator-led / COALESCE Research Fund | 6project_grants_public | |
gen_ed6bbb4acead38f282668c6284631558 | New theory to enable near-real time ecological insights into food-webs using stable isotopes | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Consolidator Laureate | 6project_grants_public | |
gen_b022f77df4fcc30e8ed151b17b264a51 | A Socio-Economic Analysis of Public Policy and Human Development in Ireland from 1847, using the SSISI e-Archive as Primary Source | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Research Development Initiative | 6project_grants_public | |
gen_9d1001ea1e5314b78ce38de41e187860 | Creating an evidence-based toolbox for targeted public health interventions during COVID-19: a cross-border analysis to disentangle psychological, behavioural, media and governmental responses | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Rapid Response Call - COVID 19 | 6project_grants_public | |
gen_abd273fbf9de4c1b156c80fb590028c7 | Identifying mental health needs and best practice for psychological support in frontline healthcare workers during and after the COVID-19 outbreak and in future pandemics. | Irish Research Council | University of Galway | Not available | Principal Investigator-led / Rapid Response Call - COVID 19 | 6project_grants_public | |
gen_cd0e7c894695fd8c0f4462c1b2394e84 | Multidimensional single cell in vivo metabolic flux analyses: Resolving immune cells based on metabolic activities at the site of disease | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Advanced Laureate | 6project_grants_public | |
gen_878675194755bdbd70f08d6c497ee85f | Buddy Walking In Fibrotic Lung Disease – Developing the 2000 Steps Initiative | Irish Research Council | University of Limerick | Not available | Principal Investigator-led / New Foundations | 6project_grants_public | |
gen_9a278bb2e096b60a3a724bb6b7a80bde | A Study Of Damage Initiation and Growth In Composite Bolted Joints | Irish Research Council | University of Limerick | Not available | Principal Investigator-led / Basic Research Grant Scheme | 6project_grants_public | |
gen_b479099efbcf4cda3c8f2079d47f4900 | Staying Engaged: Enhancing young peoples' educational well-being and mental health in post-primary schooling | Irish Research Council | University College Dublin | Not available | Principal Investigator-led / Research for Policy and Society | 6project_grants_public | |
gen_77983877e79a2aaf005d944fb2ce56a7 | Representation beyond political parties: the 2016 Irish general election | Irish Research Council | University of Limerick | Not available | Principal Investigator-led / New Horizons | 6project_grants_public | |
gen_1fab534e60a770860e625da28c05af04 | POP-NETS: Learning from Populations of Networks | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 1032-00349A | Kan man sammenligne transportnetværk fra forskellige byer? Kan vi forudsige forandringer over tid for et epidemiologisk netværk? Kan vi visualisere hvordan et hjernenetværk forandrer sig som følge af en bestemt sygdom? Alle disse vigtige spørgsmål kan besvares ved at analysere komplekse data så som netværk. Netværk beskriver fenomæner hvor interaktioner og relationer spiller en vigtig rolle. Et netværk består af en samling knuder, eller elementer, som er forbundet med kanter eller relationer. Der findes en række metoder til at løse "simple" problemer såsom at klassificere netværk i kategorier. Et langt sværere problem er at opstille sandsynlighedsfordelinger over netværk, eller forudsige nye netværk fra gamle -- for eksempel hvordan et fremtidig transportnetværk vil se ud baseret på hvordan det ser ud i dag. POP-NETS vil udnytte moderne "ækvivariante" deep learning-modeller til at designe modeller, der er i stand til at svare på spørgsmål, hvis svar er et netværk -- præcis som de spørgsmål der blev stillet i starten. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_a6c194e55ff5cc4a6d37a1303ecedba6 | Diagnostics of autoimmune liver diseases by mass-spectrometry based proteomics | Novo Nordisk Foundation | Copenhagen University Hospital - Bispebjerg and Frederiksberg | NNF23OC0084970 | Autoimmune liver diseases are relatively rare, chronic liver diseases which may affect people of all ages. Left untreated, the diseases progress to irreversible cirrhosis, liver failure, or cancer making it important to diagnose the diseases as early as possible. Unfortunately, current diagnostic liver blood tests are non-specific markers of liver damage, and a liver biopsy (tissue sample) is often required but may be inconclusive. The primary aim of this project is to identify new and better diagnostic markers of these diseases. To accomplish this, we use modern technology omics-based analyses on liver tissue and blood from 125 patients with autoimmune liver diseases and 25 healthy control participants recruited from the Gastro Unit, Copenhagen University Hospital Hvidovre. The results will provide insight into disease mechanisms including the discovery of new biomarker candidates and aid the identification of new treatments. | Research / Projects / Award | 6project_grants_public |
gen_2195f2d37159b68aa20717f59913c4ef | Data-driven Inter-Stock Predictive Analytics (DISPA) | Independent Research Fund Denmark | Aarhus Universitet | 9041-00004A | Identifikation af børssvindel og kursmanipulation er et tidskrævende arbejde for eksperter, der ydermere ofte fordrer et vist element af held, da der ikke i alle tilfælde foregår systematiske undersøgelser. Der er et signifikant potentiale for løsninger baseret på maskinlæring til at foretage systematiske analyser af børsaktiviteter, genkende irregulære handler og finde mønstre i aktiekurs-data. Sådanne løsninger kræver mindre manualt arbejde og reducerer dermed omkostninger. Dette projekt arbejder ud fra hypotesen, at handler i en aktie påvirker den fremtidige handel med andre aktier og giver anledning til mønstre, der kan genkendes med data-drevne analyser. Projektet skal designe nye metode til at detektere og forudsige kursmanipulation på tværs af aktier. Vi fokuserer på opsummering af handelsaktivitet, baseret på hop i gennemsnitspriser af aktier. Vi vil detektere disse i faktiske børsdata for at afdække relationer mellem aktiehandler og irregulære handelsaktiviteter. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_9e95717deae97ee677508bd059ca0f13 | PAPRiCaS: Programming technology foundations for Accountability, Privacy-by-design & Robustness in Context-aware Systems | Independent Research Fund Denmark | KU - SCIENCE - DATALOGISK INSTITUT | 9131-00077A | En stor grad af vores interaktion med både offentlige og private institutioner er i dag digitaliseret og styret af software systemer, der i stigende grad behandler personlige data fra forskellige kilder for at yde personaliserede tjenester tilpasset konteksten. Disse systemer består af talrige komponenter på forskellige platforme, udviklet og løbende opdateret af forskellige programmører. Den massive digitalisering har ført til regeringsstrategier, initiativer og lovgivning, ikke mindst persondataforordningen, der stiller krav til privacy-by-design, robusthed og dokumenterbart ansvar for sikkerhed og lovlig behandling data. De programmeringssprog og systemer, der i dag benyttes til at skrive og udføre programmerne med, har imidlertid ingen grundlæggende primitiver i deres design til at sikre beskyttelse af persondata og dokumenterbart ansvar, og de nuværende teknologier til at sikre robusthed er ikke designet til nutidens dynamiske systemer. PAPRiCaS etablerer et samarbejde mellem Datalogisk Institut ved Københavns Universitet og førende forskningsmiljøer i Europa, der vil bidrage til ny viden og forskningskapacitet på dette område, der vil blive overført til undervisning, og til viden og innovation i den offentlige og private sektor, og dermed sikre at vi ikke bare beholder vores førerposition indenfor digitalisering, men også at vi kan styrke vores position som udviklere af effektive og tillidsværdige digitale løsninger. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 - Digitale teknologier / grant | 6project_grants_public |
gen_5d9055ab20f50ce5ce7ee477b72c0d2b | Patient Reported Outcomes in clinical HIV care: The PRO-CARE study | Independent Research Fund Denmark | HVIDOVRE HOSPITAL | 2096-00190A | Moderne medicinsk behandling er i dag så effektiv, at personer smittet med hiv-infektion, lever lige så længe som personer uden hiv-infektion. På trods af disse positive fremskridt, har personer med hiv en øget risiko for følgesygdomme, og forskellige psykiske og seksuelle udfordringer. For at sikre at behandlingen reflekterer patienternes behov og prioriteter, er formålet med projektet at udvikle, implementere og evaluere brugen af patientrapporterede oplysninger (PRO; spørgeskemaer udfyldt af patienten) i klinisk praksis til patienter med hiv. Projektet, som udføres på Infektionsmedicinsk Afdeling, Hvidovre Hospital, består af fire studier, hvor der anvendes både kvalitative og kvantitative forskningsmetoder. Studie I er en kvalitativt fokusgruppeundersøgelse om holdninger til PRO brug i klinisk praksis hos patienter med hiv og sundhedspersonale. Studie II er en kvantitativ undersøgelse om patienternes vilje og evne til at bruge PRO i behandlingen. Studie III er en kvantitativ før-efter undersøgelse om hvorvidt brug af PRO i klinisk praksis medføre et øget fokus hos sundhedspersonalet, og Studie IV er en kvalitativ interview- og observationsundersøgelse om patienternes og sundhedspersonalets oplevelser med at bruge PROs i behandlingen. Projektets resultater kan bruges forbedre den personcentreret behandling, kvalificere mødet mellem patient og sundhedsprofessionel, samt styrke sygdomsrelateret egenomsorg hos patienter, der lever med hiv. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 - Styrket klinisk og uafhængig forskning / grant | 6project_grants_public |
gen_58575b5503c7f1e488fc667046fa5282 | Adipose tissue distribution and cardiometabolic risk in children and adolescents | Independent Research Fund Denmark | Københavns Universitet | 3101-00438A | Børn og unge med overvægt har forskellige fordelinger af fedtvæv. Om fedtcellerne primært sidder i bughulen eller på hofter og lår, og hvordan fedtvævet fungerer, kan have stor betydning for tidlig udvikling af sukkersyge og hjerte-kar-sygdom. I dette studie ønsker vi at undersøge sammenhængen mellem mængden og placeringen af det hvide fedtvæv og forstyrret metabolisme blandt børn og unge, som har modtaget behandling for overvægt. Vi vil undersøge, hvordan fedtvævet og den forstyrrede metabolisme ændrer sig under behandling, og hvorvidt disse ændringer kan forudsiges af vores sammensætning af gener og fedtstoffer og proteiner i blodet. Udover kliniske mål for fedtvævets mængde og fordeling, vil vi også kigge på fedtvævets hormoner og cellebiologi. Studiet tager udgangspunkt i mere end 1.100 børn og unge der har modtaget behandling i Enheden for Børn og Unge på Holbæk Sygehus. Vi forventer, at dette studie vil bibringe os vigtig viden omkring, hvordan fedtvævet opfører sig når man har overvægt, og hvorfor nogle udvikler mere forstyrret metabolisme end andre. Denne viden kan potentielt omsættes til den kliniske hverdag med henblik på at tilbyde en mere individualiseret og intensiveret behandling for overvægt. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_2af6b16ff7d52b53d211df8b8adecb04 | DACALY; A randomized, placebo-controlled, double-blinded Phase 2 trial of dapagliflozin for preventing treatment-associated cardiotoxicity in lymphoma | Novo Nordisk Foundation | Aalborg University Hospital | NNF23OC0085179 | Anthracyclines, mainly doxorubicin, are used in treatment of lymphoma but cardiotoxicity is a serious complication. Anthracycline cardiotoxicity is dose-dependent and even patients exposed to low doses face a risk of congestive heart failure. Patients treated with anthracyclines have excellent survival rates, and the majority become long-term survivors, making prevention of late toxicities, compromising quality of life and life expectancy, critical. This nationwide, randomized, double-blinded, phase 2 clinical trial investigates tolerability and efficacy of dapagliflozin, a SGLT2 inhibitor approved for heart failure treatment, as a cardioprotective drug in this population. The study has a potential to improve prognosis and quality of life for patients exposed to anthracycline treatment. Should dapagliflozin improve early ultrasound measures of cardiotoxicity, the current study will serve as a basis for a larger phase 3 trial to confirm efficacy with heart failure as endpoint. | Research Projects (Max 10 MDKK) / Projects / Award | 6project_grants_public |
gen_6009e0901ee8068f1d0e662ea298d939 | Hyben: Hybrid Verification of Heterogeneous Message-Passing Applications | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 2032-00310A | Bag websites og digitale webtjenester, som f.eks. rejseplanen, findes et system af distribuerede programmer, som kommunikerer med hinanden. Disse programmer understøtter vigtige funktionaliteter, men de er vanskelige at vedligeholde og udvikle: en ubetydelig fejl i et program kan påvirke hele systemet. Dertil kommer, at hvis et komplekst system ikke performer som forventet, er det både dyrt, tidskrævende og vanskeligt at finde og rette årsagen til at systemet fejler. I dette projekt forsker vi i nye metoder til at udvikle korrekte og pålidelige distribuerede software systemer. De nye metoder vil kombinere to forskellige teknikker inden for software verificering: statisk verificering ved analyse af programkode og dynamisk verificering ved at monitorere programmer medens de kører. I projektet vil vi også udvikle prototypeværktøj til software ingeniører, der vil gøre det lettere at udvikle pålidelige distribuerede systemer. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_27cbec1d805e018ee7c00e8598daa25c | Elucidating the evolutionary consequences of cryptic genetic variation and phenotypic plasticity for fungal host-shifts | Independent Research Fund Denmark | Københavns Universitet | 8049-00086A | Den globale opvarmning, moderne dyrkningsmetoder i landbruget og global transport af biologisk materiale betyder at flere patogene mikroorganismer og nye potentielle værter kommer i kontakt med hinanden. Fugleinfluenza og Ebola er nogle af de seneste eksempler på vira der har foresaget høj dødelighed efter at have skiftet fra fugle og flagermus til mennesker, men generelt ved vi meget lidt om hvorfor nogle patogene mikroorganismer skifter vært mens andre ikke er istand til det. I dette projekt vil vi i laboratoriet skabe kunstige værtsskift ved at tvinge patogene svampe der naturligt kun inficerer græshopper til at inficere sommerfuglelarver, og ligeledes tvinge patogene svampe fra sommerfuglelarver til at inficere græshopper. Dette vil gøre os i stand til at følge ændringerne i de patogene svampe igennem alle faser af disse kunstige værtsskift fra den første kontakt, gennem flere passager i de nye værtsarter til svampene forventes at vise begyndende tilpasning til den nye vært. Disse forsøg vil blandt andet kortlægge om patogen variation efter et værtsskift skyldes de samme og potentielt forudsigelige evolutionære ændringer, og hvilken rolle allerede tilstedeværende genetiske variation spiller for svampepatogeners sandsynlighed for at lave et værtsskifte. En bedre forståelse af de fundamentale genetiske ændringer som et værtsskift kræver har vidtrækkende perspektiver for vores forståelse af og mulighed for at forudsige svampesygdommes værtsskift. | Research Projects (Max 10 MDKK) / Sapere Aude: DFF-Forskningsleder / grant | 6project_grants_public |
gen_aa8e08f9d361e6e3bdbf9f2e081c4669 | Effects of indole-3-propionic acid on neurodegeneration, disease activity and cognitive decline in multiple sclerosis | Independent Research Fund Denmark | Rigshospitalet - Glostrup | 3165-00235A | Formålet med dette projekt er at undersøge, om personer med attakvis multipel sclerose (MS) kan have gavn af kosttilskud med indol-3-propionsyre (IPA). MS er en kronisk sygdom i hjernen og rygmarven og en af de hyppigste årsager til neurologisk handikap blandt yngre voksne. IPA er et molekyle, som dannes, når en lille gruppe af tarmbakterier nedbryder proteinbyggestenen tryptofan fra kosten. Celle- og dyreforsøg understøtter, at IPA kan justere på biologiske processer, som vi mener er vigtige for MS, og som de nuværende sklerosebehandlinger ikke kan rette op på. For at afprøve hypotesen vil vi udføre nedenstående forsøg: 1) et to-ugers pilotforsøg blandt raske personer, som vil hjælpe os med at identificere, den mest lovende dosis af IPA supplementering 2) et placebokontrolleret, lodtrækningsforsøg, der vil undersøge om seks-måneders IPA supplementering med start under eller kort efter akut sygdomsattak kan forhindre permanent nerveskade 3) et placebokontrolleret, lodtrækningsforsøg, der vil undersøge om supplementering med IPA kan begrænse fremtidig sygdomsaktivitet og kognitivt funktionstab blandt 200 personer med MS Vi håber, at IPA vil udgøre en af de første behandlinger, der i stedet for at supprimere immunsystemet virker ved at øge nervecellers evne til at modstå skade. Perspektivet er, at IPA kan supplementere de allerede godkendte behandlinger og på den måde bidrage til at bevare værdifuld funktionsdygtighed hos yngre voksne med MS eller forstadier sygdommen. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 - Styrket klinisk og uafhængig forskning / grant | 6project_grants_public |
gen_01dbcd9076f1b189efe16039dc5dfdec | SUgar Beet REvolution: Enzymatic Biorefining of Sugar Beet Pulp to Nutraceuticals and Recyclable Materials (SURE) | Novo Nordisk Foundation | Technical University of Denmark | NNF22OC0072911 | Sugar beet is one of the highest yielding crops in the Northern Hemisphere, with 2.5 million tons/year produced in Denmark alone. It is grown to produce sugar, but the fibrous pulp is rich in functional cellulose fibers and unique bioactive polysaccharides. Our vision is to convert sugar beet into a biorefinery crop and a leading example of how to shift from one product to sustainable production of several valuable products via side-stream bioprocessing. We propose to meet this challenge by an interdisciplinary research effort providing the scientific foundation to achieve entirely biotechnology-based fiber disassembly and optimal product functionalities. We will target microbial expansins to loosen structural cell wall assemblies, explore enzymatic separation of bioactive pectin elements and cellulose microfibrils, enzymatic lignin removal (lignin-hemicellulose linkages), study anti-inflammatory bioactivity, and learn how assembly, disassembly, and reassembly of biocomposites work. | Research / Programmes and collaborations / Award | 6project_grants_public |
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