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gen_cedac252baff2fbbcf37b19ea33eb593 | Transforming environmental engagement: Scrutinising the digital-environment nexus in Indonesia | Independent Research Fund Denmark | Københavns Universitet | 2102-00040A | Miljøødelæggelser i Indonesien forårsaget af plantage- og minedrift i stor skala har en katastrofal indvirkning på menneskers levebrød i nærområdet, men også i verden som helhed, da ødelæggelserne truer de globale økosystemers skrøbelige balancer. Her er digitale medier, som har spredt sig hurtigt i Indonesien, blevet afgørende for at kunne øge bevidstheden om sådanne miljøspørgsmål. Vi har dog stadig en meget begrænset viden om, hvordan medieaktiviteten fører til mere bæredygtig adfærd hos mediebrugere. Dette etnografiske projekt ’Transforming environmental engagement: scrutinising the digital-environment nexus in Indonesia’ søger at lukke dette videnshul gennem tre analytiske spor formuleret i spørgsmålene: 1) Hvordan bliver miljøspørgsmål skildret i onlinenyheder og sociale medier (italesættelse/’framing’)? 2) Hvordan bliver medier brugt til at mobilisere befolkningen mod miljøødelæggelser (aktivisme)? 3) Hvordan påvirker italesættelsen og aktivismen mediebrugernes miljøpraksis (rutiner)? Samlet sigter projektet altså mod at udvikle en bred forståelse af, hvilket forandringspotentiale forbindelserne mellem miljøudfordringerne og de digitale medier (the digital-environment nexus) rummer i forhold til at skabe større miljømæssig bæredygtighed. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 - Grøn omstilling/forskning / grant | 6project_grants_public |
gen_ee7bab9c63c9e8139be15e58e439ce38 | Targeting the sweet spot for splicing correction | Novo Nordisk Foundation | University of Southern Denmark, Odense | NNF19OC0058588 | Små syntetiske gensekvenser, Splice Switching Oligonukleotider (SSO), har et enormt potentiale, som individualiserede lægemidler fordi de kan binde specifikt til sygdomsgener og styre den del af genudtrykket, der kaldes splicing. For nyligt har SSOen, Spinraza, revolutioneret behandlingen af den hyppige og alvorlige sygdom, muskelsvind og understreget SSOernes enorme terapeutiske potentiale. At undersøge om en sygdom kan korrigeres med SSOer og identificere det sted, hvor SSOen skal binde, anses for at være meget vanskelig og kræve test af mange hundrede SSOer. Vi har i forbindelse med udviklingen af SSOer til adskillige gener observeret, at placering af SSOer i en region tæt ved exons virker i mere end 50% af generne. Vi kalder stedet: ”Sweet Spot”. Vi vil i projektet behandle exons fra >400 gener med SSOer for at karakterisere Sweet Spots og undersøge deres udbredelse, samt udvikle et program til forudsigelse af Sweet Spots i sygdomsgener så evt. terapeutisk potentiale kan afgøres. | Research / Projects / Award | 6project_grants_public |
gen_b9d40af427ec7b4d9b1679734d9cee2e | FysikLAB: an inspiring project based learning lab environment for high school students | Novo Nordisk Foundation | University of Southern Denmark, Odense | NNF23OC0086685 | Not available | Research Dissemination / Projects / Award | 6project_grants_public |
gen_0865809ec3c06d4dd26102579b3a41dc | Situational Crime Prevention and Ethics (SITE) | Independent Research Fund Denmark | Roskilde Universitet | 2027-00023A | Er det etisk acceptabelt at nægte visse borgere adgang til visse boligområder, eller er dette i modstrid med retten til fri bevægelse? Bør tidligere straffede borgere nægtes adgang til at kunne bo i udsatte boligområder, eller vil det være at betragte som en ekstra straf? Er det etisk acceptabelt af nægte visse gruppe af unge mennesker adgang til dele af byen (fx i parker og indkøbscentre)? Hvornår er ’gated communities’ etisk problematisk? Etiske spørgsmål af denne type bliver mere og mere aktueller og relevante i forhold til rets- og boligpolitik. Det er derfor påfaldende og problematisk, at en systematisk analyse af argumenter for og i mod denne type kriminelt præventive tiltag, stort set, er ikke-eksisterende i den internationale faglitteratur inden for Jura, Moralfilosofi og Statsvidenskab. Projektet søger at råde bod på denne mangel. Men ambitionen er også at forbedre beslutningsgrundlaget for politikere, bygherrer, byplanlæggere, designere og arkitekter når der skal træffes beslutninger der vedrører kriminalpræventive tiltag via design og byplanlægning. Tiltag som i den internationale faglitteratur bliver kaldt Situational Crime Prevention (SCP). Projektet vil også inddrage bland andet Arkitetsskolen i København og Det Kriminalpræventive Råd, som løbende kommentatore. Ideen er her at nogle etiske guidelines som beslutningstagere, kan anvende i forhold til etiske refleksioner over eksisterende og mulige former for SCP praksis. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_e3cd3e6761131cd2b95a686a6573f15b | Hunting Life: Explorations of Biosociality in Greenland | Carlsberg Foundation | Aarhus University | CF21-0306 | What? Hunting has always been the backbone of Inuit existence in Greenland. While fewer people hunt today than only 10 years ago, hunting remains the main livelihood of families and communities throughout the country. Moving beyond standard deterministic approaches to hunting, this anthropological project aims to explore the deep-seeded entanglements of human-animal worlds expressed in hunting, and how hunting is affected by (and affects) changes such as pollution, (un-)regulated hunting, fisheries, resource extraction, and sea ice. Thus, exploring dynamic practices around food, family, species, and hunting areas, the project seeks a deeper understanding of the ways in which hunting lives are made and unmade, affording new ones to emerge and old ones to reshape or disappear. Why? Using the notion of the biosocial this project contributes to understanding the many ways in which so-called biological and social worlds are not demarcated, but co-constituted: to anthropological theorization about human-animal relations within and beyond Anthropocene realities: and to the development of a conceptual understanding of fluctuations, change, and resilience in small Arctic communities. Finally, the project ethnographically tests the notion and limits of the biosocial as an analytical concept. All aspects are important to the understanding the growing complexities and nuances of sustainable human-and-animal life in the Arctic. How? The project carries out long-term ethnographic fieldwork using participant observation and interviews in three different communities in West, North, and East Greenland, taking part in, and following the everyday lives of hunting families, including retired and aspiring hunters. The project shall also work with biologists and specialists in wildlife ecosystem management - in academic settings and if possible, also in the field. We shall collaborates with hunters and their families, using inclusive and multimodal methods, for instance mobile phone camera and video, thus giving opportunity to hunters and their families to document their own practices, and, using this material as catalyst for the co-creation of knowledge and dissemination. | Research Projects (Max 10 MDKK) / Semper Ardens: Accelerate / Award | 6project_grants_public |
gen_ae99ef0c2da8400efbe75838795e7004 | Compaction of Magnets, a Property and Structure Study (COMPASS) | Independent Research Fund Denmark | Aarhus Universitet | 1127-00235A | Da Hans Christian Ørsted for 200 år siden opdagede elektromagnetismen ved hjælp af en magnetisk kompasnål, blev fundamentet for vores moderne civilisation lagt. Permanente magneter spiller i moderne tid en afgørende rolle for elektrificeringen af vores samfund, da det er magneter, som om-danner bevægelse til strøm og vice versa. I det forslåede projekt vil de nyeste videnskabelige metoder blive anvendt til at opbygge nye keramiske magneter med forbedrede egenskaber. Det sker ved at styre materialet på flere længdeskalaer, fra den atomare over nanometerskala og op til mikrome-terskala, da de endelige egenskaber af magneterne bestemmes af egenskaberne på samtlige længde-skalaer. Kontrolleret hierarkisk opbygning af materialer er nøglen til nye og forbedrede magneter, som kan være medvirkende til at fremskynde grøn omstilling inden for energiproduktion i vindmøl-ler, energibesparelser i bilindustrien og energilagring i svinghjul. Svinghjul kan også bruges til hur-tig og effektiv opladning af elbiler uden store investeringer i el-nettet. Projektet er en fælles indsats mellem Aarhus Universitet, Rutherford Appleton Laboratories (UK), University of Alabama (USA) og MAXlab (Sverige). Teknologisk Institut er inkluderet som industriel partner for at tage potentielle forskningsresultater fra laboratoriet til en industriel skala. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 - Grøn omstilling/forskning / grant | 6project_grants_public |
gen_9e1e0d2ec8b05a209631f4c6cdd5cea4 | Beyond citizen science: Hybrid intelligences | Carlsberg Foundation | Aarhus University | CF18-0019 | What? This proposal aims to create an extensive, interdisciplinary effort combining natural, social, cognitive, and computer science to address three fundamental modern challenges: Increasing the understanding of human behavior. Developing tools for systematic mapping of cognitive and psychological demographics and individualized profiling as a step towards population-scale benchmarking and individualized mental health diagnostics. These will allow us to lay the foundations for future algorithms using machine learning to build upon uniquely human search characteristics. Why? The impressive advances within artificial intelligence (AI) and machine learning (ML) are largely due to two distinct novelties: increasing computational power and the increasing availability of massive labeled datasets. Despite their success in specialized applications, they also clearly demonstrate that future AI systems will continue to rely on human insight and intuition, or even interoperate with human intelligence. Humans sometimes exhibit the ability to solve high dimensional, complex problems relying on the ability to extrapolate from sparse data, by applying domain-specific heuristics in the form of ‘intuition’. Recognizing this, we explore the potential of citizen science to better understand human cognitive processes and design human-AI systems to tackle complex challenges. How? Our unique approach is to exploit three novel uses of the citizen science: We will setup a novel infrastructure allowing for simple and flexible initialization of online, large-scale social science experiments (social science supercollider). We will create a suite of simple online games, which can be used as an orthogonal basis from which individual player cognitive characteristics can be extracted. We will utilize the massive amounts of human player data generated in natural science research games to train machine learning algorithms to tackle various problems such as search and optimization. | Research Projects (Between 10 MDKK and 50 MDKK) / Semper Ardens: Advance / Award | 6project_grants_public |
gen_d54394ea4efb588ffc78b40071b82f55 | The formation history and early habitability of Mars - Did life in our Solar System first occur on Mars? | Carlsberg Foundation | University of Copenhagen | CF18-1105 | What? Unravelling the origin and emergence of life in our Solar System is perhaps one of the most fundamental pursuits in natural sciences as it allows us to assess the potential for complex life to exist in other planetary systems in the Galaxy. Although the earliest record of life on Earth comes from ~3.8 billion years old sedimentary rocks from Greenland, little is known about the potential early habitability of other planets in the Solar System such as Mars. This project will assess the potential early habitability of Mars by probing the physico-chemical conditions that existed at the surface of the planet ~4.4 billion years ago. We will determine the early volatile inventory of the planet, including the presence of water and atmosphere, and search for signs of early biologic activity. Why? As a planetary embryo, Mars offers a unique opportunity to better constrain planet-formation processes, including the stabilization of a primordial crust. Indeed, unlike Earth, which has an active plate tectonic regime resulting in the continuous recycling of its surface, Mars lacks active plate tectonics. Thus, ancient crustal domains that date back to the earliest history of the planet can be readily preserved. A recent study from our group has suggested that Mars may have been fully formed within only 20 millions years after the birth of our Sun. Thus, conditions amiable to life may have existed on Mars much earlier than on Earth, allowing for the possibility that life in our Solar System first evolved on Mars. How? The NWA 7034 martian meteorite, discovered in the Moroccan desert in 2011, contains very ancient minerals such as zircon that date back to ~4.4 billion years ago. We will provide a detailed account of the physico-chemical conditions that existed at the surface of Mars during its solidification by investigating the geochemistry of a large population of ancient zircons extracted from the NWA 7034 meteorite. These data will allow us to assess the epoch in the early history of the planet when conditions amiable to life may have existed, including the presence of a hydrosphere. Moreover, this new and substantive zircon archive will enable a systematic search for carbon-rich inclusions encapsulated in zircons, with the objective of identifying evidence for biologic activity on early Mars. | Research Projects (Between 10 MDKK and 50 MDKK) / Semper Ardens: Advance / Award | 6project_grants_public |
gen_9438afbbaecd50118c1474b5ce721ec5 | The potential of carbon sequestration in a cost-effective EU climate policy | Independent Research Fund Denmark | Aarhus Universitet | 0217-00124A | Regulering som øger kulstofbindingen i skov og landbrug er en relativt billig måde at imødegå klimaforandringer, og kan derfor supplere andre klimaindsatser tiltag som energiafgrøder og reduceret brug af fossile brændstoffer. Der mangler imidlertid afgørende viden om, hvor og hvornår sådanne tiltag skal anvendes. Til trods for det store potentiale for øget kulstofbinding, er policy instrumenter målrettet mod kulstofbinding fraværende på EU niveau, og benyttes sjældent på nationalt niveau. Formålet med dette projekt er at analysere mulighederne for overgangen til omkostningseffektive policies for kulstofbinding i skov og landbrug i EU. Fokus for analysen er hvordan regulering skal udformes for at tage højde for at effekten af tiltag til kulstofbinding ikke er varig, samt at tiltagene er behæftet med omkostninger for effektmåling, overvågning og verifikation. Resultaterne fra analysen kan belyse mulighederne for omkostningseffektiv regulering på EU niveau, og mulighederne for at handle kulstofbinding mellem EU lande. I dansk kontekst kan analysen bidrage med nødvendig viden for at udvikle f.eks. det nationale skovprogram, det danske landdistriktsprogram samt klimapartnerskabet med fødevare- og landbrugssektoren, således at der tages højde for varigheden af tiltagenes effekt, samt målings-, overvågnings- og verifikationsomkostninger. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 - Grøn omstilling/forskning / grant | 6project_grants_public |
gen_1a287ee6031c7f75246bfe65b1269d3e | Firm Formalization and Sustainable Development | Independent Research Fund Denmark | Copenhagen Business School Handelshøjskolen | 1053-00019A | Den uformelle økonomi beskriver dele af økonomien som ikke overvåges, beskyttes eller skatlægges af myndighederne og er stort udbredt i udviklingslande verden over. Formålet med dette projekt er at undersøge om virksomheders formalisering er forbundet med bæredygtig udvikling. Selvom officielle udviklingsprogrammer som FNs verdensmål for bæredygtig udvikling og ILOs Decent Work agenda fremhæver virksomheders formalisering som en vigtig brik i at skabe bæredygtig udvikling, så foreligger der meget lidt bevismateriale som kan dokumentere denne påstand. For at belyse dette emne, vil dette projekt etablere et samarbejde med lokale forskere og brancheorganisationer i Uganda. Vi vil foretage et felteksperiment hvor tilfældigt udvalgte grupper af uregistrerede Ugandiske virksomheder vil modtage en kort erhvervsuddannelse omkring bæredygtige arbejdsmetoder samt information om formaliseringsprocessen, og efterfølgende blive sammenlignet med virksomheder, som ikke vil modtage interventionerne. Dette projekt har derfor potentiale til at bidrage med vigtige teoretiske og empiriske indsigter til gavn for både fremtidig forskning og samfundsdebatten om, hvordan formalisering er forbundet med bæredygtig udvikling. | Research Projects (Max 10 MDKK) / Sapere Aude: DFF-Forskningsleder / grant | 6project_grants_public |
gen_eb55007737f6f53423c34fdc898080e7 | Nanoscale Energy Generators (NEG) | Novo Nordisk Foundation | Aalborg University | NNF20OC0064735 | Driven by the fast miniaturization of electronic devices, development of portable electronics for sensing and monitoring of environmental conditions, personal health, or powering electrically aided body functions, is a field that currently gains strongly increasing attention. However, wearable devices are today powered by Li-ion batteries that are much larger and heavier than the devices they drive. This project aims at demonstrating that enough electrical energy to drive such devices can be harvested form body motions by generators comparable in size to microchips. These micro-generators will be based on piezoelectric materials engineered at the nanometer scale to optimize the mechanical –to – electrical energy conversion. The goal is to demonstrate a prototype of a generator on a silicon substrate with significantly increased efficiency compared to current technology and with mechanical properties designed for adoption in soft tissue. | Research Projects (Between 10 MDKK and 50 MDKK) / Projects / Award | 6project_grants_public |
gen_f89490a58bc1eb8a012e36d126798fbf | Structured treat-to-target prednisolone taper in patients with polymyalgia rheumatica | Independent Research Fund Denmark | Aarhus Universitet | 2096-00042A | Muskelgigt rammer ca. 2500 danskere årligt og er karakteriseret ved smerter omkring skuldre og hofter samt almensymptomer såsom træthed. Patienterne behandles med prednisolon, hvilket er forbundet med alvorlige bivirkninger, herunder infektioner, knogleskørhed og diabetes. Derfor er det vigtigt, at prednisolon udtrappes så hurtigt som muligt. Indførelse af en systematisk tilgang til behandlingsændringer har været det største fremskridt nogensinde ved flere andre gigtsygdomme, herunder leddegigt. Vi har lavet et studie baseret på historiske data, som viser at en systematisk prednisolon-udtrapning er effektiv. Resultatet mangler imidlertid at blive verificeret i et lodtrækningsforsøg. I studiet vil vi derfor undersøge fordele, ulemper og kost-effektivitet ved en systematisk prednisolonudtrapning via en sygeplejestyret hospitalsklinik sammenlignet med vanlig individuel udtrapning via praktiserende læge hos 120 patienter med nykonstateret muskelgigt. Patienterne følges med blodprøver og spørgeskemaer hver 3. måned og besøg efter et og to år, hvor der undersøges for kæmpecelle karbetændelse med ultralydsskanning. Projektet kan revolutionere behandlingsstrategien ved muskelgigt, da patienterne kommer hurtigere ud af prednisolon, og vi vil hermed kunne mindske sygelighed hos patienterne, bivirkninger til prednisolon samt behandlingsomkostningerne. Desuden vil vi på et tidligere tidspunkt kunne finde patienter med kæmpecelle karbetændelse, så komplikationer til denne sygdom undgås. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 - Styrket klinisk og uafhængig forskning / grant | 6project_grants_public |
gen_c31d9872e2fb3b4734cb3caef921ee4a | Chronic disease in childhood: Consequences, mechanisms, and inequality in health | Independent Research Fund Denmark | Aarhus Universitet | 8019-00055A | Projektet belyser hvorledes sygdom hos børn og unge påvirker deres trivsel, uddannelsesvalg og senere arbejdsmarkedstilknytning. I forlængelse heraf vil vi undersøge, om sygdom opstået hos et barn har negative effekter på andre familiemedlemmer end barnet selv, dvs. påvirkes søskende af at have en bror eller søster, der er syg? Ændrer forældrene deres tilknytning til arbejdsmarkedet? Ved at anvende detaljerede danske registerdata identificerer vi børn og unge, der bliver diagnosticerede med Type 1 diabetes, og sammenligner dem med børn, der ikke har diagnosen. Diabetes hos børn og unge er karakteriseret ved ikke at være livsstilsrelateret og rammer stort set tilfældigt. Vi betragter derfor diagnosen som et naturligt eksperiment, hvor tilfældige børn/familier får påvirket deres helbred og dagligdag. Vi vil undersøge, om børn med dårligere socioøkonomisk baggrund i særlig grad påvirkes af sygdommen, og om noget af denne effekt kan tilskrives evnen til at drage egenomsorg. Såfremt sygdom hos et barn også påvirker andre familiemedlemmer, skal disse også regnes med, når vi vurderer omkostningerne ved sygdom. Vi forventer, at projektet vil give indblik i mulige mekanismer, der skaber ulighed i sundhed. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 / grant | 6project_grants_public |
gen_c1b1506da15a493c13f9223b7a77bb1b | Identification of signals secreted by the gut that regulate food intake and metabolism | Novo Nordisk Foundation | University of Copenhagen | NNF19OC0054632 | The twin epidemics of diabetes and obesity are major, fast-growing global health challenges. Some of the most promising and innovative approaches to treat these conditions involve manipulating hormonal signals from the gastrointestinal tract. The gut talks to the brain and other organs by releasing hormones into the blood that relay how hungry we are, what we should or should not eat, and whether the body should store energy or burn it. Although some important gut hormones have been discovered, over 2,000 proteins with potential hormonal function exist, representing a significant unexploited resource for the discovery of new therapies against metabolic disorders. The aim of this project is to systematically identify the hormones used by the gut to communicate with the brain and other tissues to regulate appetite and metabolism. Identifying gut hormones that regulate hunger and energy storage may provide new treatments for diabetes and obesity. | Research Projects (Max 10 MDKK) / Investigators / Award | 6project_grants_public |
gen_e400be3f9281b9337d4e77fe40cabcc5 | In Adipose Tissue: Identifying Genetic Mechanisms that Uncouple Obesity from Insulin Resistance | Novo Nordisk Foundation | University of Copenhagen | NNF22OC0074128 | Obesity often leads to insulin resistance and an increased risk of type 2 diabetes. However, not all individuals with obesity are similarly affected. Given the same weight gain, individuals may be either protected from or predisposed to insulin resistance. The aim of the present project is to understand the reasons for these individual differences through genetic studies. Previously, we have found that certain DNA variants lead to a person having higher body fat but lower insulin resistance and diabetes-risk than others. We have also found that these DNA variants relate to differences in the properties of the fat tissue that the person carries. In the present project, we will use a combination of genetic studies and laboratory experiments to explain how the DNA variants change the properties of fat tissue and protect from insulin resistance and diabetes-risk. This new understanding may point towards new ways of treating obesity-related insulin resistance and diabetes. | Research Projects (Max 10 MDKK) / Investigators / Award | 6project_grants_public |
gen_9d6197e5e051967be22e45bf38cc7a12 | Structure-based engineering of glucuronoyl esterases for separation of lignin and carbohydrates | Novo Nordisk Foundation | University of Copenhagen | NNF17OC0027698 | Not available | Research / Projects / Award | 6project_grants_public |
gen_225d9346f1d0c75e9c0018c527a3a436 | Corporate Subjects: An Intellectual History of the Corporation | Carlsberg Foundation | Copenhagen Business School | CF21-0401 | What? The main aim of this project is to analyse how corporations are given existence and legitimacy as political subjects through similarities and analogies as well as delineations from human subjects and states. It argues that a central part of the existence and power of corporations is not only their status as legal persons, but that they are ascribed existence and legitimacy as political subjects. Understanding how corporations are legitimized as individuals is central to understanding how they wield political and economic power and influence. The project uses intellectual history to analyse how corporate subjects are constituted through notions of property, rights, citizenship, responsibility, liability and accountability. Why? Corporations are today powerful economic and political entities. As a result, critical research on the corporation has sprouted in a number of disciplines where it has not earlier been a focal point. This research has significantly increased the understanding of the corporation and corporate power. Intellectual history contributes to this understanding by analyzing how corporations are and have been ascribed existence and legitimacy through comparisons and similarities as well as distinctions and delineations from on the one hand human subjects, and on the other the state or political power. Intellectual history contributes by reading economic and legal texts and documents as political texts that produce and constitute political subjects. How? The project consists of three work-packages (WPs). WP1 investigates the notion of the legal person in 19th century English and German historical-legal thought and its transmission into Anglo-American corporate law. WP2 investigates the notion of the corporation found in American economic 'theory of the firm' and 'agency theory', which have been central to dominant contemporary corporate governance theory and practice. WP3 investigates the specific Danish corporate subject of the foundation, which in distinction to other corporations is truly self-owning, and which through enterprise foundations is central to Danish economic life. | Research Projects (Max 10 MDKK) / Semper Ardens: Accelerate / Award | 6project_grants_public |
gen_8c53d47b2ac75f81def4cd23c4561468 | Specialized Palliative Care – Comparing interventions | Novo Nordisk Foundation | Roskilde Hospital | NNF17OC0030144 | Not available | Research / Projects / Award | 6project_grants_public |
gen_6dc543df09dec1a732f6511462bd32c5 | Social Media and Political Representation (SoMeRep) | Independent Research Fund Denmark | Københavns Universitet | 0133-00034A | Sociale medier har ændret rammerne for den politiske dialog og bruges i stigende grad af både politikere og borgere til at diskutere politik. Med udgangspunkt i de nyeste metoder indenfor social datavidenskab undersøger projektet, hvad den øgede brug af sociale medier betyder for den demokratiske debat og uligheder i demokratisk repræsentation i tre lande: Danmark, Storbritannien og USA. Det undersøger bl.a., om der er forskelle i, hvilke grupper af borgere, der er repræsenterede i den politiske kommunikation, afhængigt af om den foregår på sociale medier eller offline. Projektet undersøger også, hvor lydhøre politikere er overfor de politiske ønsker og prioriteringer, borgere udtrykker på sociale medier, samt hvordan politikeres brug af sociale medier varierer. Endeligt zoomer projektet ind på digital dannelse og undersøger, om der er forskel på, hvilke reaktioner sociale minoriteter og kvinder får på deres adfærd på sociale medier sammenlignet med resten af befolkningen. Projektet indsamler et omfattende datamateriale ved blandt andet at koble data fra spørgeskemaundersøgelser blandt borgere og politikere i de tre lande med en analyse af deres adfærd på sociale medier. Samtidig gennemfører det felteksperimenter i de tre lande. Projektet har både tværfaglig og samfundsmæssig relevans og vil generere resultater, som kan bidrage til at styrke det repræsentative demokrati. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 / grant | 6project_grants_public |
gen_dd433cd386e9b7da51929f33cf40307e | Intensive Beta-cell Rescue at Diagnosis of Type 1 Diabetes | Novo Nordisk Foundation | Oslo University Hospital | NNF23OC0084371 | We have demonstrated a low-grade, persistent infection with live enteroviruses in the insulin producing beta-cells at diagnosis of type 1 diabetes (T1D). We also detected inflammation, antiviral tissue responses, increased cellular stress and several possible mechanisms that may kill the beta-cells and cause T1D. In a randomized clinical trial we recently demonstrated a beneficial effect of antiviral therapy in preserving residual insulin production. To improve these effects we want address several mechanisms and test a 6 months combination treatment: 1) Intensified insulin treatment by automated insulin pumps to near-normalize blood sugar, 2) Antiviral drugs (pleconaril and ribavirin), 3) Anti-inflammatory drug (etarnecept) to reduce inflammation around the beta-cells, 4) verapamil to reduce cell stress. 24 patients aged 10-18 years will be included in an open, controlled pilot trial for one year and compared with 100 age and gender matched patients using traditional treatment. | Research / Projects / Award | 6project_grants_public |
gen_4c80eaa965b29e6304161835c5085425 | Overleveringer – en empirisk undersøgelse af billedhugger Kirsten Justesens virke og arbejdsarkiv | Novo Nordisk Foundation | National Gallery of Denmark | NNF17OC0025368 | Not available | Research / Projects / Award | 6project_grants_public |
gen_d3fdcc17b7ce1e7386320b312a76f47c | Anyons in new settings | Independent Research Fund Denmark | Aarhus Universitet | 8049-00074A | Anyoner er en form for partikler, der har meget usædvanlige egenskaber. De kan opstå i grænselaget mellem to halvledere under de rette betingelser. Deres eksistens har udfordret flere grundlæggende fysiske principper og ledt til ny indsigt. Den næste generation af teknologi vil bygge på kvantemekaniske effekter, og det har vist sig, at anyoner også er en lovende platform til at bygge en kvantecomputer. Anyoner er blevet detekteret under ekstreme forhold, men der er stadig meget, vi ikke ved om dem, og der er brug for mere forskning, inden vi kan udnytte dem teknologisk. Vores mål er dels at rykke grænserne for anyonforskning ved at realisere anyoner i systemer, der har andre egenskaber end de systemer, hvor anyoner tidligere er blevet fundet, og dels at udvikle metoder til at opnå mere kontrol over anyoners dynamik, hvilket er afgørende for teknologiske anvendelser. Vi vil undersøge muligheder for at have anyoner i strukturer med forskellige dimensioner, hvilket kan lede til grundlæggende ny fysik. Vi vil også lede efter anyoner i systemer, hvor anyoner kun kan bevæge sig, hvis de aktivt bliver skubbet. Det er et skridt på vejen til at bygge anyonkvantecomputere, der kan operere ved høje temperaturer. Endelig vil vi undersøge, hvordan man skal styre anyonerne i en anyonkvantecomputer for at få de mest pålidelige resultater ud af en beregning, hvis man kræver, at beregningerne er gennemført i løbet af en bestemt tid. | Research Projects (Max 10 MDKK) / Sapere Aude: DFF-Forskningsleder / grant | 6project_grants_public |
gen_e889283757ad682f1bf9c44ad3692168 | Examining the association between maternal BCG scar status and pregnancy outcomes – A hospital-based study from Guinea-Bissau | Independent Research Fund Denmark | Syddansk Universitet (University of Southern Denmark) | 2117-00033A | I >40 år har Bandim Health Project forsket i vacciners effekt på den samlede sundhed. Herigennem blev det opdaget, at mange vacciner har uspecifikke effekter - altså effekter, der rækker udover beskyttelsen mod målsygdommen. Studierne har primært fokuseret på børn, men nu har forskerne også fundet en sammenhæng mellem tilstedeværelse af et ar fra tuberkulosevaccinen BCG (også kendt som Calmette) hos mødre og lavere risiko for barnedød i de første måneder efter fødslen. Disse studier har primært omfattet børn som forskerne fulgte efter at de var blevet vaccineret ved udskrivelse fra fødeafdelingen, men et nyligt studie har indikeret, at BCG-vaccinerede mødre måske også har en mindre risiko for at tabe barnet i løbet af graviditeten. Dødfødsler er et stort problem, især i lavindkomstlande, og vi mangler effektive midler til at forebygge dem. På fødeafdelingen på det største hospital Guinea-Bissau har ca. 60% af de fødende kvinder et ar fra BCG vaccinen. Via en dataindsamling over 1 år, tæt superviseret af vores forskerhold, vil vi indsamle individuelle data om de fødendes BCG ar og koble disse til forekomsten af dødfødsler og dødsfald kort efter fødslen, med kontrol for baggrundsfaktorer. Såfremt tilstedeværelsen af et BCG ar sænker risikoen for disse udfald vil studiet bane vejen for at vi kan forhindre mange dødfødsler og dødsfald kort efter fødslen ved at vaccinere kvinder, der ikke har et ar, og dermed nå ud til og beskytte de sidste ca. 40% af børnene. | Research Projects (Max 10 MDKK) / Skolarstipendier | Sundhed og Sygdom / grant | 6project_grants_public |
gen_63f710428597e601e32e7e443184fc1d | Screening and intervention for subclinical coronary artery disease in patients with type 2 diabetes (Steno INTEN-CT Study) | Novo Nordisk Foundation | University of Aarhus | NNF22SA0081107 | Not available | Research Projects (Between 10 MDKK and 50 MDKK) / Programmes and collaborations / Award | 6project_grants_public |
gen_bfa1b1f18eefea0629610abbb3bcc8ec | BOON - Behavior Oracle for always-ON electrical mobility | Independent Research Fund Denmark | DTU Management Engineering | 0217-00065A | Not available | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt2 - Grøn omstilling/forskning / grant | 6project_grants_public |
gen_8e78306c069507c20442b034c971b0dd | In-depth studies of glucagon sensitivity to glucose and lipid kinetics, IGF1 axis, liver histology and lipid intermediates in Non-alcoholic fatty liver disease | Independent Research Fund Denmark | Aarhus Universitetshospital | 9039-00177A | De seneste årtier er befolkningen blevet tiltagende overvægtig og derfor ramt af overvægtsrelateret diabetes og fedtlever (NAFLD), som findes hos op til 30% af mennesker i den vestlige verden. NAFLD kan potentielt give anledning til øget sygelighed og dødelighed, og især den sværere form for NAFLD, non-alkoholisk steatohepatitis (NASH), giver risiko for hjertekarsygdom og skrumpelever. Der forskes intensivt i, hvordan NAFLD udvikler sig, for at man mere effektivt kan forebygge og behandle. Der findes aktuelt ikke godkendte lægemidler mod NASH. Vi ved at NAFLD opstår hos patienter med unormal lipid- og glucoseomsætning i leveren. Især er glucose- og lipidproduktionen øget i leveren, og triglycerid eksporteres til blodbanen. Hormonet glucagon er en vigtig regulator af leverens lipid- og glucoseregulation, men vi ved aktuelt ikke om glucagons effekt er påvirket hos NAFLD patienter. Vi ønsker at undersøge glucagons effekt på især lipidomsætningen hos 12 raske, 12 patienter med mild NAFLD og 12 patienter med NASH med avancerede metoder. Vores hypotese er at NAFLD patienter har en påvirket lipid- og glucoseomsætning under infusion af glucagon, hvilket bl.a. resulterer i at NAFLD patienter frisætter for meget triglycerid og glucose til blodet, og at forandringerne er størst hos NASH patienter. Resultaterne vil hjælpe til at identificere nye behandlinger for NAFLD og dermed danne grundlag for fremtidige studier i NAFLDs udvikling og behandling, lokalt og internationalt. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_e5af04b7713d2595da7f39f2d6a7d6ac | Angiotensin-(1-5): Characterisation of a new blood-pressure lowering mediator within the renin-angiotensin-system | Independent Research Fund Denmark | Syddansk Universitet | 0134-00297A | Angiotensin II (Ang II) er et vigtigt hormon når det kommer til regulering af blodtrykket. For store mængder af kan dog Ang II forårsage hypertension, dvs. abnormalt højt blodtryk, som kan føre til organskade. Udover Ang II, findes der flere forskellige biologiske aktive fragmenter af Ang II. Bemærkelsesværdigt er det, at disse fragmenter har modsatrettede effekter set i forhold til Ang II, dvs. de virker blodtrykssænkende og beskytter organerne. Dette foreslået projekt, vil teste hvorvidt et af disse Ang II fragmenter, kaldet Angiotensin-(1-5) [Ang-(1-5)], som på nuværende tidspunkt er anset for at være inaktivt, i virkeligheden er aktivt og virker beskyttende. I de første forsøg i celler, isolerede arterier samt anæsteserede mus, har vi observeret stor evidens for at Ang-(1-5) virker blodtrykssænkende ved at frigive et molekyle kaldet nitrogenmonooxid. Vi vil i detaljer studere de mekanismer der giver Ang-(1-5) arterieudvidende- og blodtrykssænkende egenskaber samt undersøge hvorvidt denne for nyligt identificeret egenskab ved Ang-(1-5), eller lignende molekyler, i fremtiden kan anvendes som lægemiddel til behandling af hypertension. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_f7e3d46af9ab0d8fb991d9f7dcc731d4 | Neutron scattering assisted quantitative design of high pressure synthesized polymer hydrogels dedicated to antibiotics carriers | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 6111-00140A | Not available | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_f6b85011582e4dcfb4462283d07c07f2 | Next-generation route choice models for behavioural realism and large-scale applications | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 0136-00242A | Trængslen på de danske veje er stigende, og dagligt spildes hundredtusindvis af timer pga. forsinkelser specielt i Hovedstadsområdet og andre stærkt trafikerede områder. Forsinkelserne giver et enormt samfundsøkonomisk tab, og også på det personlige plan påvirker trængslen og den medfølgende uforudsigelighed af rejsetider vores liv og dagligdag. Derfor er det essentielt, at den eksisterende infrastruktur udnyttes optimalt med mindst mulig trængsel til følge, samt at udbyttet af potentielle infrastrukturinvesteringer maksimeres. I den forbindelse er det vigtigt, at beslutningstagere har adgang til en velfungerende trafikmodel, der giver en realistisk repræsentation af rejsendes rutevalg. Selv de mest avancerede af nutidens rutevalgsmodeller er imidlertid adfærdsmæssigt urealistiske. Desuden kan de ikke anvendes i storskala-trafikmodeller uden at der gås på kompromis med den teoretiske konsistens. Projektets formål er at udvikle en adfærdsmæssig realistisk model til beskrivelse af rejsendes rutevalg. Denne model vil på konsistent vis kun allokere trafik til relevante ruter, og lade ruter der er alt for lange eller indeholder urealistiske omveje være ubenyttede. Projektet vil også udvikle tilhørende efficiente løsningsalgoritmer, der muliggør konsistent anvendelse af modellen i storskala. Modellen og algoritmerne vil blive valideret via et case-studie, der beskriver daglig transport i Danmark samt en datakilde baseret på GPS-data indeholdende en stor mængde faktiske rutevalg. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_d87001863733710b00b0f4692b80c783 | PRECISE - PREdiction of Ice Sheets on Earth | Novo Nordisk Foundation | University of Copenhagen | NNF23OC0081251 | Sea level rise is one of the most dangerous risks of global warming, threatening coastal communities across the world and potentially flooding hundreds of millions of people annually by the year 2100. Projections of sea level rise are uncertain with a metre-scale uncertainty in the projections from the International Panel of Climate Change (IPCC), and not including additional uncertainties related to ice sheet-instability processes. This uncertainty presents a major challenge for planning adaptation strategies and assessing mitigation solutions. PRECISE will develop current ice flow models used for projections to enable them to react to extreme weather and more melting in a future warmer climate. New descriptions of crevasses and porous ice will be used, and climate feedbacks will be estimated using AI and new data. The goal is to provide robust projections of sea level rise for IPCC assessments with quantified uncertainties and to communicate the results to relevant stakeholders. | Research Projects (Between 10 MDKK and 50 MDKK) / Programmes and collaborations / Award | 6project_grants_public |
gen_00ed49fea0283ffde34caf4f0db664ba | TIPARP and mono-ADP-Ribosylation Regulate PPAR activity | Novo Nordisk Foundation | Oslo University | NNF17OC0027072 | Not available | Research / Projects / Award | 6project_grants_public |
gen_cf2d24b29e44dbcc6356087ddcaa650e | Metabolic Mechanism(s) Supporting Stem Cell Potency | Independent Research Fund Denmark | Københavns Universitet | 0134-00022A | Ændret metabolisme, eller hvordan celler genererer energi, har stor indflydelse på differentiering og sygdom, men hvordan forårsager ændringer i en celles energitilstand unikke celleidentiteter? Vi har for nylig forbundet cellemetabolisme med øget funktion af embryonale stamceller (ESC) - deres evne til at blive til alle celletyper i den fremtidige organisme, både embryonale og ekstra-embryonale. ESC er cellelinjer, der etableres ved at gro tidlige pattedyrsembryoer i en petriskål og isolere celler, der kan vokse videre i kultur, men samtidig har bevaret evnen til at udvikle sig til de specialiserede celler, der udgør organismen. Dog har ESC mistet evnen til at lave ekstra-embryonale celletyper, som moderkagen, og anses derfor ikke som totipotente, men pluripotente. Vi har opdaget, at vi kan give ESC et medie, der ændrer deres metabolisme og gør dem totipotente, så de spejler de tidligste stadier i embryonal udvikling. Her spørger vi, hvordan metabolisme transformerer ESC til dette "mere potente" stadie. Hvordan instruerer metabolisme ESC til at aktivere gener, der specificerer denne særlige celletype? Derudover ønsker vi at identificere naturlige signaler, der giver tidlige embryonale celler besked om at ændre metabolisme og potentiale. Med dette studie ønsker vi at klargøre, hvordan energiforbrug hænger sammen med genetisk regulering og dermed give indsigt i cellers reaktion på skiftende miljøer med forskellige energikilder - under udvikling, aldring og tumordannelse. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_4138b412fb3ffb2ee3ff17bb3ca91cef | PURE_CAP: Preventing the Use of Restrictive practices in Child and Adolescent mental health Patients: A Multiple case study and qualitative interview study | Independent Research Fund Denmark | Psykiatrisk Afdeling Middelfart | 3166-00023A | Undersøgelser har vist at sammenlignet med voksne har børn og unge større risiko for at blive udsat for tvang under indlæggelse. Herudover udsættes den enkelte hyppigere for tvang og de er ofte underlagt tvangen i længere tid. Tvangen kan være i form af overvågning, fastholdelse, anvendelse af bælte og/eller remme og medicin. De fysiske konsekvenser af anvendelse af tvang mod børn og unge er øget risiko for blodpropper, for udvikling af læsioner, kvælning og for tidlig død. De psykologiske konsekvenser er ikke undersøgt, men det formodes, at tvang skader relationen mellem barnet/den unge og personalet, at tvangen skader barnets muligheder for udvikling af sunde tilhørsforhold samt tryg og sammenhængende udvikling af identitet, selvopfattelse og relationære kunnen. Derfor er det vigtigt at nedbringe anvendelsen af tvang mod børn og unge. Formålet med dette projekt er at skabe viden om brugen af tvang i blandt indlagte børn og unge i psykiatrien herunder igennem journaler, patienters, de pårørendes og personales perspektiver at udvikle viden om de udløsende og forværrende forhold før brug, forlængende forhold under brug og ift pleje efter brug af tvang. Ved at forstå disse sammenhænge ønsker vi at kunne tilrettelægge målrettede interventioner der kan nedbringe brugen af tvang i børne-unge psykiatrien. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 - Bedre rammer for psykiatrien / grant | 6project_grants_public |
gen_06432cc73e26e99233e6ed7452006fa2 | Chromium-Catalyzed (De)Hydrogenation Reactions | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 9041-00171A | Reaktioner med brint udgør de vigtigste katalytiske transformationer til fremstilling af organiske molekyler. Det gælder især hydrogeneringer, hvor brint reageres med et umættet substrat, men også dehydrogeneringer er væsentlige transformationer, hvor brint spaltes fra et organisk molekyle. Desværre er homogene katalysatorer til disse reaktioner meget kostbare, da de ofte består af ædelmetaller eller andre dyre metalforbindelser. Desuden kræver disse metaller i reglen ligander, som består af bekostelige og følsomme fosforforbindelser. I projektet vil homogene kromforbindelser derfor blive udviklet som katalysatorer til både hydrogeneringer og dehydrogeneringer. Krom koster kun $10/kg, som skal sammenlignes med $35000/kg for palladium og $80000/kg for rhodium. Desuden fungerer krom med nitrogenholdige ligander, som er billigere og mere stabile end de tilsvarende fosforforbindelser. Krom findes i flere oxidationstrin, og der vil kun blive anvendt relativt uskadelige forbindelser i de lavere oxidationstrin. Projektet vil først optimere en kromkatalysator til fraspaltning af brint fra alkoholer og analysere mekanismen for denne reaktion. Derefter vil den nye katalysator blive anvendt til en række dehydrogeneringer og hydrogeneringer, hvor de mest værdifulde anvendelser er fremstilling af amider og estere direkte fra alkoholer samt asymmetriske hydrogeneringer til syntese af optisk aktive molekyler. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_238314cf836016dbca77d488f656ae45 | Exploring new ways of classifying medication use in pregnancy for better observational research | Independent Research Fund Denmark | STATENS SERUM INSTITUT | 9039-00055A | Om en gravid kvinde skal anvende en given medicin under graviditeten eller ej, er en afvejning af fordele og ulemper, og det er ofte ikke muligt at give et sikkert svar. Dette skyldes at gravide kvinder ikke deltager i de kliniske lægemiddelafprøvninger og, at man derfor i mange tilfælde er henvist til studier af kvinders medicin forbrug i den virkelige verdens mere ukontrollerede rammer. I mange af den slags studier, sammenligner man kvinder der har brugt en bestemt type medicin under graviditeten med kvinder der ikke har anvendt denne type medicin. Dette er en forsimpling, der dækker over mange komplicerede medicin forbrugs mønstre. Forskellige kvinder bruger forskellige doser af medicinen, starter og stopper på forskellige tidspunkter i graviditeten, og bruger måske andre typer af medicin samtidigt. I dette projekt ønsker vi at undersøge brugbarheden af forskellige metoder der bedre tager højde for disse ”naturalistiske” medicin forbrugs mønstre. Vi tager udgangspunkt i de unikke danske sundhedsregistre, og fokuserer på den konkrete problemstilling om brug af antidepressiver i graviditeten udgør en risiko for barnet. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_a89e71ea408dedd3a86bddcd64ea122a | Quantum Mechanical Cluster Perturbation in Condensed Phases | Independent Research Fund Denmark | Københavns Universitet | 3103-00261A | Bølgefunktion baseret elektronisk strukturteori har udviklet sig omkring tre standardmodeller: konfiguration-interaktion (CI) teori, koblet klynge (CC) teori og Møller-Plesset (MP) perturbationsteori. Hver model har sine egne styrker og svagheder med hensyn til nøjagtighed og beregningseffektivitet. Til sidst har CC-modellerne udviklet sig til at blive de foretrukne metoder. Formålet med dette forslag er at udvikle en ny klasse af universelle bølgefunktionsmodeller – cluster perturbation (CP)-modellerne – hvor styrkerne af standard CC-, CI- og MP-modellerne kombineres for at opnå en enklere og mere effektiv beskrivelse af jord- og exciterede energier og molekylære egenskaber, end der kan opnås ved brug af standardmodellerne for for molekylære systemer i kondenserede faser og ved nanopartikler. Derved vil vi udvikle cluster perturbation (CPET) miljøteori. CPET-modellerne ved design har potentialet til at erstatte de nuværende avancerede modeller. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_34b67344c260a171376c58b6c55eb32c | The role of membrane vesicles in bacterial resistance to antimicrobials and their potential for targeted therapeutic interventions | Carlsberg Foundation | University of Copenhagen | CF20-0385 | What? Bacterial and host membrane vesicles (MVs) play important roles during infection. Whereas host MVs are released in response to bacteria and may bind and neutralise bacterial toxins, bacterial MVs may counteract detrimental host responses, bind and disable various antibiotics, and may play a role in antibiotic resistance. Antimicrobial host defence peptides (HDPs) are regarded as very promising alternatives to antibiotics. However, it is unknown whether MVs may bind and incapacitate HDPs as well. Therefore, in this project we will focus on understanding the interplay between HDPs and MVs during infection. Additionally, we will study specificity of host MVs, as well as bacterial MVs from different strains, to explore their potential for targeted delivery of antimicrobials. Why? Antibiotic resistance development in bacteria has become an increasing issue in human medicine, animal husbandry and agriculture. As more antibiotics have become ineffective, focus has shifted towards alternative antimicrobial therapies such as HDPs, which may not only kill a broad spectrum of microbes, including multi-resistant strains, but also modulate host inflammatory responses. However, the antimicrobial activity of many HDPs is compromised under physiological conditions. Moreover, pathogenic bacteria may mimic the formation of HDPs to evade host responses. Therefore, the use of HDPs as antimicrobials is not as straightforward as once thought, and understanding extracellular resistance mechanisms of bacteria towards the antimicrobial activity of HDPs is essential. How? In order to address the roles of host and bacterial MVs in relation to the function of HDPs, we will investigate the effect of various HDPs on bacterial and host MV release, composition and function. We will also investigate how binding of HDPs to these vesicles affect the biological activity of the peptides. For this purpose, we will use a broad range of methods within physical chemistry, molecular biology, microbiology, cell biology, immunology, microscopy, and proteomics. Furthermore, we will investigate how HDP-MV binding affect bacterial recognition and antibacterial responses by host cells. Finally, we will investigate the existence of species selectivity of MVs. | Research Projects (Max 10 MDKK) / Semper Ardens: Accelerate / Award | 6project_grants_public |
gen_26d2a35c380cf23909481143f08d5693 | Resolving beta-cell dysfunction in Type 2 and Mitochondrial Diabetes | Novo Nordisk Foundation | Lund University | NNF22OC0078267 | Type 2 Diabetes is caused by the combined action of gene variants and environmental factors. This results in reduced insulin secretion due to an impact on the cells that release insulin. It has been nearly impossible understand how these risk genes cause loss of insulin secretion – scientists have neither had access to insulin-secreting cells from risk patients nor been able to correct underlying genetic variation. These hurdles have now been removed – we can make insulin-secreting cells from skin cells in patients carrying risk genes, using stem cell technology. In these insulin-secreting cells, we can correct the risk genes, by replacing a single DNA base, that confers the genetic risk. Using this approach, we will examine how risk genes, as well as mitochondrial DNA mutations, contribute to the development of diabetes. Stem cell lines we have created will be deposited in a biobank – LUNiPS – available to the research community. Our results may result in novel drugs for diabetes. | Research / Projects / Award | 6project_grants_public |
gen_eaa784227603ab0ac4bf4b8bf0acb300 | Synergetic impacts of stressors on biodiversity in a rapidly changing Arctic | Independent Research Fund Denmark | Aarhus Universitet, Bygning 1130 - 1131, 1134 | 3120-00045A | Det arktiske klima er i hurtig forandring. Faktisk stiger temperaturerne her op til fire gange hurtigere end på resten af kloden, og de arktiske økosystemer beskrives ofte som de værende de mest følsomme overfor klimaforandringer. De dramatiske klimaforandringer forventes at medføre store og uoprettelige skader på økosystemet. Desværre er den nuværende viden om arktisk biodiversitet for mangelfuld til at forstå disse forandringer. Dette skyldes at det marine dyre og planteliv kun i ringe grad er blevet undersøgt, men også at klimaforskningsstudier oftest kun har undersøgt organismers respons på én enkelte stress-faktorer (f.eks. temperatur). Denne respons er så blevet brugt til at estimere følsomheden af hele samfund og økosystemer. I kystnære økosystemer udsættes organismer dog for mange stressende faktorer på en gang (f.eks. varme og forurenende stoffer). Når en organisme udsættes for flere faktorer kan effekterne mangedobles. For at forstå klimaforandringerne i Grønland, undersøger dette projekt hvordan havets biodiversitet er, og bliver, påvirket af ændringer i miljøet. Ved at kombinere biodiversitetsundersøgelser med komplekse eksperimenter og molekylære analyser på udvalgte nøglearter, kan projektet belyse hvordan artsspecifikke responser vil påvirke følsomheden af de kystnære samfund og økosystemer over klimaforandringer. Ultimativt til projektet give de første indikation på hvordan den arktiske natur vil se ud i en varmere fremtid. | Research Projects (Max 10 MDKK) / Sapere Aude: DFF-Forskningsleder / grant | 6project_grants_public |
gen_ddf51e645765fac550f33d0568dd2468 | Reduction of emotional and physical harm at surgery cancellation - Development, pilot-testing and evaluation of a complex intervention | Novo Nordisk Foundation | Aarhus University Hospital | NNF21OC0072570 | This project concerns the issue of harm in relation to surgery cancellation. Surgery cancellation is an ongoing challenge in healthcare systems, and it may cause emotionally and physically harm on patients, including feelings such as lack of control, anxiety and mistrust. Furthermore, symptoms such as sleeping disturbances, stomach trouble and depression in the new waiting period. Thus, the purpose of this project is to explore how the health sector can manage surgery cancellation in a far more systematic and supportive manner by developing a Surgery Cancellation Care Programme, pilot-testing and evaluating the effect. The care program will contain different components at the cancellation procedure and in the new waiting period tailored patients' individual needs. Our goal is to reduce anxiety and depression, raise quality of life and care experience in patients. A strong supervisor team with national and international participants will support completion of the project. | Research / Fellowships / Award | 6project_grants_public |
gen_1a0967c27b760347b86c135b1c57cbfc | Mispricing in Financial Markets and its Real Effects | Independent Research Fund Denmark | Aarhus Universitet | 7024-00020A | Finanskrisen har endnu engang rejst spørgsmålet om, hvorvidt de finansielle markeder altid afspejler den rigtige pris på finansielle aktiver, eller om de lejlighedsvis over- eller undervurderer deres værdi. Formålet med dette forskningsprojekt at forbedre vores forståelse af hvornår og hvorfor de finansielle markeder værdiansætter aktiver forkert, samt at forstå de samfundsøkonomiske konsekvenser herfra. Traditionelt har man indenfor finansiering og makroøkonomi alene brugt økonomiske strukturer til at forstå de finansielle markeder, men det er velkendt at psykologiske faktorer også har en betydning for udviklingen på de finansielle markeder. I projektet inddrages derfor psykologiske aspekter i en makroøkonomisk model, så betydningen heraf kan vurderes. Derudover gør dette forskningsprojekt det også muligt at afdække eventuelle finans- og pengepolitiske tiltag, som kan mindske de negative samfundsmæssige effekter af et overvurderet aktiemarked. | Research Projects (Max 10 MDKK) / Sapere Aude: DFF-Forskningsleder / grant | 6project_grants_public |
gen_dc870535546ddcbb213b10c3f2923fce | Brain-gut-pancreas immune axis regulates FoxA1+Tregulatory cells to prevent multi-organ inflammation | Novo Nordisk Foundation | University of Copenhagen | NNF21OC0072256 | Inflammatory diseases like inflammatory bowel disorders, diabetes, and brain inflammatory disease, multiple sclerosis are among growing diseases worldwide. These illnesses afflict more than 23.5 million people in America alone, and the prevalence is rising, expected to double over the next 25 years. These diseases are mainly caused by disturbed immune cells. Immune cells normally are responsible for patrolling body for search of invading bacteria and viruses, to fight and clean them, and finally withdraw from the fight. However, sometimes immune cells get confused and keep attacking our own tissues causing chronic inflammatory illnesses. Therefore, it is important to understand how these diseases are developing and how to change the fate of inflammatory immune cells to become anti-inflammatory and withdraw from harm-causing. We have identified one such group of cells called FoxA1+Tregulatory cells. We wish to study if they are relevant for controlling inflammatory diseases. | Research / Projects / Award | 6project_grants_public |
gen_704105de025b26386dc6214fc90aef1a | The effect of chronic cold stimulation on brown fat and health in humans | Novo Nordisk Foundation | Copenhagen University Hospital | NNF17OC0029918 | Not available | Research / Projects / Award | 6project_grants_public |
gen_44f9da5e25dc7bbea4794761af8a9a4c | Establishing the significance of brite/beige versus classical brown adipocytes in the control of energy metabolism | Novo Nordisk Foundation | Stockholm University | NNF21OC0070165 | Obesity is not only a significant problem in itself but is also a major inducer of type 2 diabetes, cardiovascular disease and certain forms of cancer. At present there is little understanding of the cause of obesity, except for the self-evident statement that it arises from an imbalance between energy intake and energy expenditure. Even minor but chronic perturbations in either of these two components can lead to an increase in body weight. The identification of a novel type of adipocytes, so-called brite or beige adipocytes, that appear to possess the ability to increase energy expenditure and that are localized within the white adipose depots themselves, has provided a basis for studying new opportunities for counteracting the development of obesity. It is the goal of the present studies to gain insight into the functional significance of the brite/beige adipocytes by understanding how to reactivate them in a mouse model relevant for human physiology. | Research / Projects / Award | 6project_grants_public |
gen_8f28af5169e6c95014c166c159569e42 | The effect of metoprolol on myocardial function, perfusion and hemodynamics in symptomatic patients with hypertrophic obstructive cardiomyopathy. | Novo Nordisk Foundation | University of Aarhus | NNF19OC0052289 | Hypertrophic obstructive cardiomyopathy (HOCM) is a hereditary disease with thickening of the heart muscle, causing shortness of breath and fatigue. Symptoms are provoked by exercise. No curable treatment exists, and the first step in managing symptoms is with the use of the medicine beta-blocker (BB). Metoprolol is the most commonly used BB in HOCM patients, but evidence of the presumed positive effect is very sparse. In a group of HOCM patients, we will carry out the so far largest study of metoprolols effect on the cardiac function during exercise. Patients will be examined with blood pressure catheters in the chambers of the right heart at rest and while conducting a bicycle load test. Each patient is examined twice, during metoprolol and during placebo treatment. The results will 1) document the effects of metoprolol in HOCM patients 2) provide unique insight into disease mechanisms in HOCM, and 3) guide whether a HOCM patient should be offered more invasive treatment. | Research / Projects / Award | 6project_grants_public |
gen_7909697dc26190e6d9183174929a4acf | Roman Carthage: A Reappraisal | Carlsberg Foundation | University of Southern Denmark | CF23-1813 | Publication of papers from an international conference on Roman Carthage in Rome in January 2022.What? Why? How? | Research / Publication / Award | 6project_grants_public |
gen_43f6d3e71b196544101d894e48227bd9 | Circular Economy and Women Entrepreneurship for the UN-SDGs | Carlsberg Foundation | University of Southern Denmark | CF21-0679 | What? The aim of CEWE-UN SDGs is to launch a new research agenda exploring the nexus of women entrepreneurship (WE) and circular economy (CE). The project also aims to develop a novel toolkit for women entrepreneurs to perform circular business, which contributes to the United Nations' Sustainable Development Goals (UN SDGs). Specifically, this project helps to reverse the declining rate of women/female entrepreneurs in Denmark by innovative thinking and designing business practices for a circular economy to achieve the UN SDGs. Why? Circular economy and UN SDGs have been a popular topic in recent years. Smaller, less-established businesses are more likely to pursue sustainability-related opportunities because entrepreneurial ventures are more flexible and can adapt their business models to bring about radical sustainability-oriented innovations. Recently, from a sustainability perspective, women entrepreneurs represent the fastest-growing category of entrepreneurship worldwide who positively contribute to true sustainable development. However, despite the topic's popularity, there is a scarcity of knowledge in the academic literature and business practice about how entrepreneurs behave and launch new ventures in a circular economy. How? This project includes three interrelated work packages that uniquely contribute to developing a new theory named circular women entrepreneurship to achieve UN SDGs. This project utilizes various qualitative and quantitative research methods such as systematic literature reviews, surveys, focus groups, expert opinion, case studies, and interviews. Thus, this project paves the way for collaboration with national and international experts within the fields of the circular economy and women entrepreneurship. | Research Projects (Max 10 MDKK) / Semper Ardens: Accelerate / Award | 6project_grants_public |
gen_efad2bc6ca36a093e8686bc73fa3064a | Greenhouse gases dynamics in shallow lakes: patterns and processes from cells to ecosystems (GreenLakes) | Independent Research Fund Denmark | Aarhus Universitet | 9040-00195A | Lavvandede søer udgør den mest hyppige type søer ikke kun i Danmark men også globalt. Disse søer er også en vigtig kilde af drivhusgasser så som kuldioxid, metan og lattergas, og en stigende drivhusgaskoncentrationen i atmosfæren fører til ændringer af Jordens klima. Vi vil forstå hvordan drivhusgasfrigivelsen fra disse søer påvirkes af fremtidige klimaændringer samt en stigende næringssaltbelastning. Begge faktorer kan føre til en stigende drivhusgasfrigivelse som igen fører til temperaturstigninger. Vi gør brug af en enestående eksperimentelle opstilling ved Aarhus Universitet for at undersøge denne sammenhæng. Opstilling består af 24 kunstige søer, hvoraf 8 følger omgivelsestemperaturen, i 8 søer holdes temperaturen ca 2 grader og i de restende 8 søer ca. 4 grader over omgivelsestemperaturen. Desuden tillsattes ekstra næringssalte til halvdelen af søerne. Dette resulterer i søer med høj såvel som med lav næringssaltbelastning. Vi vil bestemme drivhusgasfrigivelse samt antal og aktivitetsstatus af de bakteriegrupper som er ansvarlig for produktion og forbrug af drivhusgasserne ved de forskellige behandlinger. Vores resultater vil hjælpe os til at forstå sammenhæng mellem stigende temperaturer, næringssaltbelastning og drivhusgasfrigivelse og dermed forbedre vore forudsigelser af hvordan drivhusgasfrigivelsen ændres i fremtiden og endnu mere vigtigt hvordan forskellig forvaltningspraksis vil påvirke drivhusgasfrigivelsen fra denne dominerende type søer. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_ab6a88291b7ae29edcb3575c78c95cc1 | Danish data collection for a large multi-country study hosted at Yale University: Global moral messaging to change the public’s behavioral intentions during the COVID-19 pandemic | Independent Research Fund Denmark | Københavns Universitet | 0213-00052A | COVID19-pandemien udfordrer samfund over hele kloden. Der er lange udsigter til at egentlige vacciner eller antiviral medicin er færdigudviklede til at stoppe pandemien. I mellemtiden viser forskningen, at vores bedste løsning er at ændre folks adfærd i dagligdagen for at hindre yderlige sygdomsspredning. Det handler om god hånd hygiejne, holde afstand til andre og aflyse sociale begivenheder med venner og familie. Spørgsmålet er, hvordan man mest effektivt overtaler mennesker til at foretage denne form for gennemgribende ændringer i deres hverdagsliv? Dette er et socialvidenskabeligt spørgsmål, der grundlæggende handler om, hvilke typer af moralske argumenter, man skal bruge for at sikre adfærdsændringer. Skal man tale til argumenter om generel nytte eller pligter som samfundsborger? I dette projekt bliver spørgsmålet undersøgt blandt danskere i en række surveyeksperimenter. Projekt indgår i stort tværnationalt forskningsprojekt, der dækker over 10 lande med forskningshold fra de fleste verdensdele og som ledes fra Yale University. Dermed giver projektet viden om effektive argumenter til ændring af borgernes adfærd under COVID19, der, ligesom sygdommen, går på tværs af landegrænser. Viden fra projektet kan hjælpe regeringer og myndigheder med at målrette og optimere effekten af adfærdskampagner rettet mod borgerne. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 - Corona / grant | 6project_grants_public |
gen_3709472b00529006eb00d354f9b1ff18 | Identification and functional characterization of novel regulators of genome maintenance | Independent Research Fund Denmark | Københavns Universitet | 8020-00221A | DNA udgør grundlaget for biologisk liv og det er derfor afgørende for biologiske organismers udvikling og sundhed at vedligeholde dets integritet. DNAs integritet udfordres kontinuerligt af både interne og udefrakommende påvirkninger og manglende reparation af beskadiget DNA kan have katastrofale konsekvenser. Således er genomisk instabilitet en vigtig årsag til sygdomme som kræft og præmatur aldring. Cellers mekanismer til at reparere DNA skader involverer akkumulering af mange proteiner på det sted hvor skaden er opstået, men vi har endnu ikke en fuld forståelse af DNA reparationsmekanismerne. Målet med dette forskningsprojekt er at anvende innovative proteomiske metoder til systematisk at kortlægge det netværk af proteiner der udfører reparation af DNA skader og karakterisere deres cellulære funktioner og molekylære mekanismer. Et positivt udfald af dette projekt vil øge vores forståelse af de molekylære mekanismer der vedligeholder genomet og kan give os ny indsigt i sygdomsmekanismer samt potentielt føre til identifikation af nye behandlingsmuligheder for humane sygdomme. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_0de5dfb319d8e0f4eab575033011ad30 | Urinary Extracellular Vesicles as Novel Tools for Diabetes Management | Novo Nordisk Foundation | University of Helsinki | NNF18OC0034200 | Not available | Research / Projects / Award | 6project_grants_public |
gen_1fb298364f9c792bfd82ea00f6929d8c | PAST PAIN: A Pathway Approach to STop neuropathic PAIN with spinal cord stimulation | Independent Research Fund Denmark | Aalborg Universitet | 3163-00013A | Smerte er en sensorisk og emotionel oplevelse. Nuværende kliniske og videnskabelige metoder fokuserer dog udelukkende på den sensoriske del af smerte, og tager ikke højde for den emotionelle eller affektive side. Dette projekt vil bruge rygmarvsstimulation (SCS) til at mindske aktivitet i både de sensoriske og affektive smertebaner. SCS mindsker smerte intensiteten og forbrug af smertestillende i mere end 50% af neuropatiske smerte patienter. Terapien retter sig kun til de sensoriske smertebaner, dog har dyrestudier vist at den også påvirker neuroner i de affektive smertebaner. Yderlige er der forhøjet aktivitet i de affektive smertebaner efter en neuropatisk skade. Det forventes at SCS kan mindske den forhøjede aktivitet i både de affektive og sensoriske smertebaner samtidig (WP1), hvilket resulterer i mindre smerte-relateret adfærd (WP2). De aktivitetsmønstre der ses på rygmarvsniveau anvendes til udvikling af en computer model, som kan frembringe stimulationsmønstre der mere effektivt end nu, mindsker aktiviteten i de sensoriske og affektive smertebaner. | Research Projects (Max 10 MDKK) / Inge Lehmann-programmet / grant | 6project_grants_public |
gen_60d858f98e9b44aec9a0383f3a1bbe2f | Understanding how diet and metabolism affect cancer | Independent Research Fund Denmark | Københavns Universitet | 0134-00045A | Dannelsen af kræft og dens videre udvikling er i høj grad afhængig af ændringer I den cellulære metabolisme idet kræftceller undergår et metabolisk skifte til et øget glukoseforbrug ved en proces kaldet aerob glykolyse, eller Warburg-effekten. Derudover er det kendt, at risikoen for at udvikle særlige typer af kræft er stærkt associeret med flere metaboliske lidelser, herunder type 2 diabeses og overvægt, og at patienter med metabolisk dysfunktion har øget kræftrelateret dødelighed. Selvom både metabolismerelaterede sygdomme, og et metabolisk skifte i de maligne celler per se, har betydning for dannelsen og udviklingen af kræft, er forståelsen af de molekylære mekanismer, som forbinder disse metaboliske forandringer med sygdomsudviklingen i cancer, fortsat meget begrænset. I dette projekt vil vi bruge dyremodellen Drosophila melanogaster til at undersøge hvordan metabolisk reprogrammering og metabolismerelaterede sygdomme påvirker udviklingen af kræft. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_cdf313cdfc537b940de4471b14604978 | Metabolic and Transcriptomic Profiling of Women with Postpartum Depression | Independent Research Fund Denmark | Statens Serum Institut | 6120-00099A | Fødselsdepression (FD) er en alvorlig lidelse, der rammer 5-15% af alle kvinder efter fødslen. Ubehandlet, kan sygdommen have alvorlige konsekvenser for mor og barn på både kort og lang sigt. I langt de fleste tilfælde er FDs episoder ikke behandlingskrævende, og forekommer i mange tilfælde hos kvinder, der ikke tidligere har haft nogen former for psykiske lidelser. Man ved meget lidt om de specifikke årsager til FD hos kvinder uden tidligere psykiske lidelser. Der er dog noget der tyder på, at reproduktive hormoner, muligvis i samspil med gener, spiller en vigtig rolle i udviklingen af FD hos disse kvinder. Vi vil udnytte helt ny teknologi til at undersøge metabolisk aktivitet og hvilke gener der udtrykke i FD kvinder sammenlignet med raske kvinder kort efter fødsel. Kvinderne vil blive rekrutteret i samarbejde med sundhedsplejersker fra Københavns Kommune som systematisk screener alle kvinder kort efter fødslen. Samtidig udnytter vi det nationale fødselskohorte studie hvor 100,000 kvinder har deltaget, og hvor der nu findes opbevaret blodprøver taget i løbet af deres graviditet. Som en del af denne kohorte vil vi undersøge blodprøver fra 600 kvinder taget under deres graviditet, og som senere udvikler en alvorlig FD og sammenligne dem med blodprøver fra 600 raske kvinder. På baggrund af resultaterne fra første studie vil vi undersøge markører der er specifikke for FD for deres evne til at forudse en kommende FD. Ved at studere metaboliske markører og gener associeret med FD | Research Education (PhD) / Forskeruddannelse uden for universiteterne / grant | 6project_grants_public |
gen_a35393f13afe6cf3fc313750d25f61b5 | Who Influences Child Health? The Impact of Physician Characteristics and Practice Styles on Preventive Care Take-Up and Outcomes | Independent Research Fund Denmark | VIVE - Det Nationale Forsknings- og Analysecenter for Velfærd | 8019-00051A | Projektets formål er at undersøge betydningen af alment praktiserende lægers karakteristika og behandlerstil for børns deltagelse i de forebyggende børneundersøgelser, det danske vaccinationsprogram, og deres sundhed på kort og længere sigt. Selvom der er universel adgang til forebyggelse for alle børn i Danmark, er der stor forskel i tilslutningen til fx de forebyggende børneundersøgelser. Denne variation kan have langsigtede negative konsekvenser for nogle børn, og vi vil undersøge, hvilken rolle alment praktiserende lægers karakteristika og behandlerstil kan spille for at fremme take-up af forebyggende behandlinger og (på længere sigt) børns sundhed og udvikling. Projektet bidrager til to områder i økonomisk forskning: På den ene side viser en stor empirisk litteratur, at faktorer, tidligt i børns liv, deriblandt interaktioner med deres forældre, har stor betydning for børns sundhed og sociale udfaldsmål på længere sigt—men vi ved lidt om betydningen af tidlige interaktioner med fagprofessionelle, som praktiserende læger. På den anden side tyder et voksende antal studier på, at karakteristika og behandlerstilen af udbyderne af sundhedsydelser kan have stor betydning for omkostninger, patienternes behandling og sundhed—men man har ikke fokuseret på børn og ambulante kontakter. Vores projekt udnytter danske registerdata og et kvasi-eksperimentelt design til at bidrage med ny viden, som kan anvendes til at forbedre børns adgang til og udbytte af forebyggende sundhedsydelser. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_fb5700c28c2cbd6aa9259a9fd503276a | Controlling ice growth to create micro-channel structures | Independent Research Fund Denmark | Danmarks Tekniske Universitet | 6111-00073A | Mikrokanaler er interessante for en række teknologier, fra rensning af vand til varmevekslere. I en mikrokanal komponent er arbejdet der skal anvendes på at skubbe en væske igennem komponenten lav, mens interaktionen mellem væsken og selve komponenten er høj. Dette er fordelagtigt for eksempelvis varmevekslere, da en stor mængde varme kan overføres mellem væsken og komponenten. I dette projekt vil vi anvende frysestøbning til at producere komponenter med mikrokanaler, og efterfølgende teste disse i en magnetisk kølemaskine, da forskning har vist at denne teknologi bliver 50% mere effektiv med mikrokanaler. I frysestøbning fryses is så det danner mikroskopiske istapper igennem en pulveropløsning og presser pulveret ud af istapperne. Efterfølgende frysetørres isen væk og komponenten brændes for at konsolidere den til ét fast stykke. Udfordringen med frysestøbning er at det er svært at producere mikrokanaler som er længere end få millimeter, fordi frysestøbningsprocessen ikke kontrolleres fint nok. Den videnskabelige hypotese i dette projekt er at hvis den præcise grænse mellem is og vand under frysestøbningen kan følges, gennem infrarøde målinger, så kan der udvikles en metode til at styre hastigheden hvormed istapperne vokser, hvilket gør styring af bredden og længden af mikrokanalerne muligt. Dette vil blive gjort eksperimentelt og eftervist med simuleringer. Succeskriteriet for projektet er at producere komponenter med en længde på 5 cm med 100 mikrometer bredde kanaler. | Research Projects (Max 10 MDKK) / DFF-Forskningsprojekt1 / grant | 6project_grants_public |
gen_596da1d97f19ac1a1a08416066348dcd | Directional Data Delivery for Wireless Immersive Digital Environments (3D-WIDE) | The Finnish Research Impact Foundation | University of Oulu | Extended reality and immersive digital environments will set extremely high-performance requirements for wireless networks. Field tests in the first 5G networks have proven 5G capability for a Gbps access link on mm-waves. However, immersive viewing in multi-user environments requires extremely high area capacity, which is not yet achieved with 5G. In this project, Nokia Bell Labs and Centre for Wireless Communications of University of Oulu devise an emerging vision of mmWave-based mobile immersive digital environment, delivers a physical layer connectivity framework accounting for specific effects of directional mmWave connectivity, and allows efficient utilization of the increasingly affordable in-device memory via multipoint coded caching. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_db65a1af28653a4b0c9fe44a537840cb | Improving immuno-oncology tools to fight cancer: the use of complex immune organoids for testing the efficacy of peptides coated oncolytic viruses (PeptiCRAd / PeptiENV) | The Finnish Research Impact Foundation | University of Helsinki | Immunotherapy has revolutionized cancer treatment in the past 10 years, however the access for patients to experimental trials is still slow. It is clear that there is a need to develop new “human-based” models that better recapitulate the disease. Organoids are “mini-tumors” grown in the laboratory. They retain very similar characteristics as patients’ tumors and are excellent platforms to test new immunotherapies and accelerate their track to the clinic. To this end, scientists at iCAN have decided to partner with Valo Therapeutics to explore the possibility to use complex immune organoids to test the two lead immunotherapy drugs that Valo is developing. If successful, this will generate scientific breakthrough and significantly accelerate Valo’s path towards personalized cancer therapy. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_737d8ed2baa92b16e71b1d85e660b3c7 | Surface passivation for semiconductor devices and electroluminescent cooling | The Finnish Research Impact Foundation | Aalto University | Surface defects play a role in essentially all semiconductor devices. In SuperDevice we study the use of the controlled oxidation developed by Comptek Solutions Oy in eliminating the detrimental surface recombination in thermophotonic GaAs based optical cooler prototypes investigated at Aalto University. This enables a case study of using controlled oxidation in state-of-the-art compound semiconductor devices, potentially eliminating one of the key bottle-necks presently slowing down the development of optical cooling technologies that may later on revolutionize solid state as well as general cooling applications. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_8f411a1854d53373ba4fb15b53c2bb79 | Constituents of a quantum computer | The Finnish Research Impact Foundation | Aalto University | Quantum computers are projected to revolutionize information processing. This project taps into the core of this revolution and helps the growing ecosystem to bring forward major innovations paving the way for a useful quantum computer. Thus this project is of great importance and the ambition level is very high. However, taking the exceptionally strong foundations of the local quantum community, we foresee this project to be feasible. Namely, here the strong academic expertise of Aalto University and especially that of the Quantum Computing and Devices (QCD) research group meets with a European leader in quantum computer hardware, IQM. The joint effort of these two front runners will bring major added value and expedite the growth and scale up of the academia and the industry. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_c1fd6d31e7c5abaee37493eefad0794d | Superior infrared sensors | The Finnish Research Impact Foundation | Aalto University | The project develops new type of infrared sensors with superior sensitivity. The project utilizes material knowhow and expertise present at Aalto University related to so-called black silicon that is proven to have superior optical and electrical properties. Black silicon is, however, not applicable material for detecting infrared radiation. Thereby, the project will develop high quality (and black) material structures to Ge-substrates that are known to absorb well also IR radiation. The developed structures will be then applied directly to devices with the help of the industrial partner (ElFys Inc.) who has relevant knowhow, facilities as well as knowledge for the device requirements. The studied applications include medical tools, optical communication as well as security applications. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_e1557da56b036aadd749293a43d76c4b | The Economies of Ox: Scaling up Oxidative Processes to Streamline Synthesis | The Finnish Research Impact Foundation | University of Jyväskylä | The main goal of the project is to develop safe, scalable methods for oxidations and oxidative couplings for use in the production of active pharmaceutical ingredients (APIs) by chemical synthesis. Oxidations and oxidative reactions are some of the most challenging reactions to scale up in pharmaceutical production. Nevertheless, increasing the oxidation state of the molecule by these reactions often provides very attractive shortcuts to synthetic production routes, cutting off the number of steps and providing alternative, less wasteful and less costly methods for synthesis. The goal of this project is to develop safe oxidation and oxidative coupling methods based on catalytic transfer oxidations and other benign terminal oxidants, bearing the scalability and safety always in mind. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_a1e9af6a0ba637f7eb64a37fa80682d2 | Language Identification of Speech and Text | The Finnish Research Impact Foundation | University of Helsinki | The project is dedicated to the advancement of computational methods for automatic language identification. Speech user interfaces are becoming more popular in everyday life. However, almost all the current commercial products using speech interfaces have to be manually set to understand a certain language as no automated language identification methods are used. The project is situated at the department of Digital Humanities of the University of Helsinki and the industrial partner is Lingsoft Oy. Lingsoft develops and uses their own speech recognition solution for a number of different use cases, the most important from a current business perspective are subtitling for television and medical dictation. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_b99ba20b20f470b6a91e1a717c507d1e | Improved sampling of aerosol nanoparticles | The Finnish Research Impact Foundation | Institute for Atmospheric and Earth System Research | This project improves the reliability of aerosol measurements by developing the sampling methods of nanoparticles and studying the phenomena affecting the particles during sampling. We will measure the possible impact of sampling and dilution on the size and composition of aerosol particles smaller than 10 nm in diameter. We will characterize the losses of nanoparticles in the Airmodus AND sampling system and test its applicability to atmospheric measurements and industrial applications. The project creates new knowledge about the interactions between aerosol nanoparticles, gases and ions. The project partners are Insitute for Atmospheric and Earth System Research at University of Helsinki and Airmodus Ltd. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_ec17bfd59eb5968de18b947cc8dde35d | Thermodynamic properties of aqueous transition metal sulfate solutions of industrial importance | The Finnish Research Impact Foundation | University of Oulu | The aims of the project are experimental and computational research of strong transition metal sulfate solutions, in close collaboration with Boliden Kokkola. These transition metal electrolyte solutions, such as zinc, cobalt, and nickel sulfate solutions, are industrially relevant eg. due to the increased use of lithium-ion batteries. New scientific data of the solubility properties of metal salts is produced, with the aim to understand related process phenomena at the fundamental level. This data is applied to control and/or even to prevent industrially relevant process challenges. Project is highly ambitious, because the properties of electrolyte solutions are not known, and reference data does not exist. Thus, modelling requires also new reliable experimental data, which is produced. | Tandem Industry Academia (2020) | 6project_grants_public | |
gen_4744023106b48da52d6e36b4a1bbc262 | Surface functionalized core/shell drug crystal nanoparticle platform for targeted delivery | The Finnish Research Impact Foundation | Åbo Akademi | Many new drugs show great promise in laboratory trials, but they often have poor solubility or fail to reach their targeted site. This joint project between Åbo Akademi and Bayer uses microfluidics technology to develop surface-functionalized, nanosized drug crystals for more accurate and targeted drug delivery. Improved drug solubility and targeting contributes to improved drug efficacy and safety. The collaborative setting will facilitate the transfer of academic discoveries directly into commercial product development. In this way the project could have momentous impact on pharmaceuticals development globally. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_6026caac94d643b9ba37dc292b3b32fa | Developing optimal methane mitigation strategy for milk production by animal breeding | The Finnish Research Impact Foundation | Natural Resources Institute Finland | Methane emissions from ruminants are a key factor in reducing the environmental footprint of dairy production. Methane levels can be reduced either by selecting low-emitting cows or indirectly by improving feed efficiency. The assessment of feed efficiency, however, has been complicated by the absence of technically and economically feasible tools. This joint project between Natural Resources Institute Finland and Valio will be working to develop a method for detailed analysis of feed efficiency based on the measurement of cows’ respiratory gases. The volume of oxygen consumed and carbon dioxide produced provide crucial information on the metabolism of cows. The same device can be used to simultaneously measure the gas exchange of about 25 cows, and the data generated can help to reduce both methane emissions from dairy production and other environmentally detrimental gases. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_0d00856631ac98c91f5ba9f76156d1ba | Development of an artificial intelligence integrated full life cycle assessment tool for road infrastructure in Finland – AI-FINROADS | The Finnish Research Impact Foundation | Aalto University | What is the environmental impact of road transport? Aalto University and Ramboll have joined forces in a bid to find answers. Their joint project will develop a life cycle analysis (LCA) framework for Finnish road conditions using artificial intelligence. This framework will, for example, help reduce waste from road construction and help design road systems with lower emissions. The LCA framework will incorporate a range of climatic factors unique to Finland, which are often not considered in typical LCA studies. The knowledge created in this project can be used to inform decision-making and the development of a sustainable road infrastructure. Industry representatives will gain access to a practical application that can deliver accurate environmental impact assessments in various project contexts. The results will be shared openly thereby contributing to the development of more sustainable road infrastructure globally and especially in the Nordics. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_251110de3d86425423b43fb89cb25e06 | Sustainable Innovation for Growth: Exploring circular business models for a logistics service provider | The Finnish Research Impact Foundation | Hanken School of Economics | The circular economy is a model to conserve natural resources, reduce emissions, and create sustainable growth. Logistics companies have a critical role in advancing circular economy solutions in that their supply chains and business models provide opportunities to extend the life cycle of products. However, theoretical understanding of the role of supply chain management and logistics in the circular economy is still in its infancy. This collaboration between Hanken School of Business and Posti will explore how logistics service providers can become enablers and value creators in circular business models. Business model experiments will be conducted in a real market environment with customers and partner companies. The project will employ the design science research method, the results of which are directly applicable in company strategies. The Principal Investigator for the project is Anna Aminoff. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_45c065aec773a79c49fb0e4a9a98b24a | Advanced ecosystem models in multiobjective use of forest resources: More raw material and better ecosystem services from every hectare (AEMES) | The Finnish Research Impact Foundation | University of Helsinki | Forests are loaded with both environmental and economic expectations. Attempts to reconcile these diverse objectives may create conflicts and undermine the public acceptability of forestry. This joint project between the University of Helsinki and Metsähallitus is geared to promoting multiobjective forest management and use. It focuses simultaneously on wood production, climate impacts, nutrient loads on waterways, and biodiversity. One of the project’s outputs will be a new tool for comparing different types of forest management chains. A better understanding of these chains will allow for more effective planning and increased wood production while reducing adverse environmental impacts. The scientific information produced by the project will help to support more informed decision-making, and the so-called ecosystem models developed in the project and the related machine learning and optimization applications will be widely available in forest planning, environmental technology, consulting companies, and in the wider society. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_8a5fbe5ac1cb294eefdb35daad92ebdf | GeoAI explained soil mapping of Finnish forests | The Finnish Research Impact Foundation | University of Helsinki | The properties of forest soil are a crucial determinant of what type of forest management yields the best results. Accurate identification of the soil type helps in selecting the most appropriate tree species, assessing the regenerative capacity of forest soil, and determining the passability of the soil during different seasons. Tailoring forest management measures to suit each site helps to improve carbon sequestration, reduce environmental damage, and ultimately increase the public acceptability of forestry. This joint project between the University of Helsinki and Arbonaut will develop a deep-learning based method for producing accurate forecasts of forest soil properties for use by all forestry operators. It will also explore how best to visualize data on soil properties for different types of decision-making situations in forest management. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_d12f7a67bb436f2f27b917bf969dfd7f | Towards real-world neuroscience approaches: Mobile brain-body imaging (MoBI) for predicting dementia risk | The Finnish Research Impact Foundation | Aalto University | Memory disorders have significant economic, social, and indirect treatment costs. Even though memory disorders develop gradually over time, they are hard to predict with existing medical methods. This collaboration between Aalto University and Bittium Biosignals is aimed at developing an early dementia risk screening tool for the ageing population. Its focus is to study mild cognitive impairment (MCI), i.e. the intermediate state between normal brain ageing and memory disorder. About half of the people with MCI progress to dementia, especially Alzheimer’s disease. The project makes use of mobile brain-body imaging (MoBI), which allows data collection in people’s everyday natural environment, and computational modelling, which improves diagnostic sensitivity. In addition to dementia risk screening, the methods developed in the project will contribute to diagnostic tools for other neurological disorders, such as Parkinson’s disease and post-traumatic stress disorder (PTSD). The Principal Investigator for the project is Hanna Renvall. | Tandem Industry Academia (TIA) Postdoc (2024) | 6project_grants_public | |
gen_5544becd2d0a0f03d88cd7c67bb29050 | INTEGRATED NOVEL STRATEGIES FOR REDUCING THE USE AND IMPACT OF PESTICIDES, TOWARDS SUSTAINABLE MEDITERRANEAN VINEYARDS AND OLIVE GROVES | European Commission | Centre de Recerca en Economia i Desenvolupament Agroalimentari (CREDA-UPC-IRTA) | CORDIS-101000554 | The DIRECTIVE 2009/128/EC ON THE SUSTAINABLE USE OF PESTICIDES gives directions for attaining the sustainable use of pesticides in the EU. The objective is to minimize risks and impacts for the environment and human health by promoting alternative strategies. Integrated Pest Management (IPM) is one of the cornerstones of the Directive. NOVATERRA aims to reduce the use and negative impacts of CONTENTIOUS PLANT PROTECTION PRODUCTS (PPP) for integrated pest, disease and weed management in the two main Mediterranean crops in Europe: grapevines and olives. NOVATERRA will develop a pool of novel, integrated and sustainable strategies, technically and economically viable, resulting from three different approaches: a) To develop novel combinations of ALTERNATIVE, non-synthetic PRODUCTS and biological control techniques for plant protection, b) To optimize the application and dosage of PPP through SMART FARMING technologies and c) To mitigate the appearance of pest and diseases through the use of new SOIL MANAGEMENT strategies. Those approaches will be evaluated and validated in a combination of integrated solutions for updating and improving IPM strategies. Indicators for measuring the impact of crop management and protection on human health, air, water, soil, biodiversity, energy will be implemented. Further analyses will be done in terms of economic cost-benefit for farmers to adopt the different techniques and farmers and consumers’ willingness to pay. The consortium composition will guarantee a multi-actor approach with contributions coming from research institutions, growers, technological SMEs, auxiliary industry and relevant associations. Finally, the Exploitation Plan together with the Communication and Dissemination Plan will ensure the outreach of results among the stakeholders in the European farming sector. NOVATERRA outputs will also be key for further discussion with policymakers in terms of EU plant health policies and risk assessment around PPPs usage. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_30f7b9221f198dad796245616a62419c | Creating added-value chemicals from bio-industrial CO2 emissions using integrated catalytic technologies | European Commission | AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS; STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK | CORDIS-101000580 | In 2017, EU GHG emissions, including emissions from international aviationEurope has successfully reduced its GHG emissions since 1990 levels. The pace of reducing CO2 emissions is positive, however it is projected to slow after 2020 resulting in difficulties to achieve EU’s reduction target of 55% by 2030 as planned in the European Green Deal. Additional measures and policies are foreseen in EU to forefront this situation. Negative emissions technologies, as carbon capture, utilization and storage (CCUS) ones are currently a priority to explore, especially in non-exploited industrial sectors such as the bio-based industry as they significantly contribute to CO2 emissions. CATCO2NVERS will contribute to reduce GHG emissions from the bio-based industries developing 5 innovative and integrated technologies based on 3 catalytic methods (electrochemical, enzymatic and thermochemical). It will transform waste-CO2 (up to 90%) and residual biomass from 2 bio-based industries into 5 added-value chemicals (glyoxylic acid, lactic acid, furan dicarboxylic methyl ester (FDME), cyclic carbonated fatty acid methyl esters (CCFAMEs) with production yields between 70-90%. Methanol which will not have an energetic use but will be used in CATCO2NVERS own technologies. These target chemicals will be used as building blocks and monomers to obtain biopolymers of 100% bio-origin. Industrial partners will validate the application of the obtained chemical building blocks on the most relevant markets. In addition, the waste-CO2 stream will be conditioned by removing potential inhibitors for the catalysts. CATCO2NVERS will meet some of the principles in green chemistry (atom economy, use of renewable feedstocks, reduce derivatives and use of catalysts instead of stoichiometric reagents). CATCO2NVERS will explore an energy and resource efficient scenario following an industrial symbiosis model to ensure a biorefinery process along the CO2 valorization chain with zero or negative GHG emissions. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_e19def7096885086a5d7b57fcbaa35a7 | Bio-based local sustainable circular wear | European Commission | ANONYMI ETAIREIA VIOMICHANIKIS EREVNAS, TECHNOLOGIKIS ANAPTYXIS KAI ERGASTIRIAKON DOKIMON, PISTOPIISIS KAI PIOTITAS; THE UNIVERSITY OF THE ARTS LONDON; SOURCEBOOK GMBH | CORDIS-101000632 | HEREWEAR innovates with a holistic, systemic approach towards the creation of an EU market for locally-produced circular textiles and clothing made from bio-based waste. New material solutions will build on the latest bio-based polyesters and cellulose developments. Three novel waste streams (seaweed, manure, straw) will be developed for cellulosic textile fibres. Emerging sustainable technologies for wet and melt spinning, for yarn and fabric making, will be developed and piloted at semi-industrial scale. For finishing innovation, coating and colouring biobased agents will be evolved. Microfibre release will be significantly reduced via measures all along the textile manufacturing process. Garment prototypes for streetwear and corporate clothing will be produced by connecting up microfactories, organised into regional value creation circles; or by platform-supported, networked production resources. Use phase and end-of-life processing management - repair, re-use, recycle - will be implemented through novel structures. Full transparency will be provided through blockchain-enabled labelling and the configuration of a digital twin, informed with LCA information. A database and guidelines will be produced to support the design of fashion goods; with a focus on the best performance for bio-based materials and for reuse/recycling. Further guidelines will help the industry to take-up these results. The consortium includes 6 research organisations, 1 LE and 8 SMEs coming from EU and 1 from US. To maximise impact, we will build on the TCBL community (>240 sustainable textile businesses) and use the SOURCEBOOK platform (>25000 organisations). Via these networks, blueprints for the transition to bio-based circular textiles will be shared and implemented. That way HEREWEAR aims to establish a bio-based circular textile clothing market segment of ca. €300 million, thus trying to maintain ca. 1200 textile manufacturing jobs in EU. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_29a81d07edf6f11d081468e8bb26f35a | Diversifying revenue in rural Africa through circular, sustainable and replicable bio-based solutions and business models | European Commission | Barcelona Plataforma Empresarial; ASSOCIATION D'APPUI AUX INITIATIVES DE PAIX ET DE DEVELOPPEMENT | CORDIS-101000762 | Africa will need to feed over 2 billion people by 2050 while coping with unprecedented demographic, socio-economic, environmental, climatic and health transitions. Meanwhile, undernourishment is still on the rise, affecting almost 20% of its population now. Under this light, ensuring Africa’s food security becomes imperative, with the bioeconomy posed to play a leading role to this end. It is against this backdrop that BIO4AFRICA sets off to support the deployment of the bioeconomy in rural Africa via the development of bio-based solutions and value chains with a circular approach to drive the cascading use of local resources and diversify the income of farmers. Our focus is on transferring simple, small-scale and robust bio-based technologies adapted to local biomass, needs and contexts (green biorefinery, pyrolysis, hydrothermal carbonisation, briquetting, pelletising, bio-composites and bioplastics production). In doing so we aim at empowering farmers to sustainably produce a variety of higher value bio-based products and energy (animal feed, fertiliser, pollutant absorbents, construction materials, packaging, solid fuel for cooking and catalysts for biogas production), significantly improving the environmental, economic and social performance of their forage agri-food systems. To this end, we have set up 4 pilot cases with over 8 testing sites in Uganda, Ghana, Senegal and Ivory Coast, offering more than 300 farmers and farmer groups of all sizes (incl. small dairy and lower-income farmers, women farmer groups and transhumant pastoralists among others) the opportunity to test them in real productive conditions. Along the way, our balanced mix of 13 African and 12 EU partners will engage in solid multi-actor collaboration with rural communities and government, co-developing novel sustainable value chains driven by circular business models and supporting deployment in other areas, all while safeguarding agronomic, environmental, social and economic sustainability. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_b396b05a01154aba5e72024ebb04c777 | Climate Resilient Orphan croPs for increased DIVersity in Agriculture | European Commission | SAATZUCHT STEINACH GMBH & CO KG | CORDIS-101000847 | Agrobiodiversity is a vital subset of biodiversity and is the result of the interaction between the environment, genetic resources and management systems used by culturally diverse people. It is a crucial prerequisite for ecologically and economically sustainable agricultural systems and is an important tool for ecological intensification. The aim of CROPDIVA is to reinforce agrobiodiversity on different levels and along distinct geographic and socio-economic areas. The activities of CROPDIVA are clustered around five connected research work packages and three pillars, each with a set of specific objectives: i) promotion of six key underutilised arable crops: oats, hull-less barley, triticale, buckwheat, faba bean and lupin; ii) creation of value chains for selected underutilised crops ; and iii) study of the socio-economic impact of project results. The concept of CROPDIVA is an innovative challenge driven approach based on the promotion of underutilised crops in sustainable cropping systems and new regional value chains. Project activities will focus on the following major challenges: improved resilience of cropping systems, alignment of the economic and social needs of farmers with ecological goals as well as marketing of new food/non-food products meeting consumer demands. The results gathered in CROPDIVA will not be descriptive, but will be used for innovative solutions along the entire food and non-food chain to enable biodiversity management on all levels, including diversifying the use of genetic resources, crop production systems, new food/non-food products, market opportunities while satisfying producers and investigated consumer requirements. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_2bcb93a34a1993ff32ab56c59a59a382 | CO-creating sustainable and competitive FRuits and vEgetableS’ value cHains in Europe | European Commission | Stichting Food Valley; Wageningen University and Research Centre; ASSOCIATION EUROPEENNE DU COMMERCEDE FRUITS ET LEGUMES DE L'UE | CORDIS-101000852 | Starting from current best practices and key success factors observed and analysed in innovative value chains and the state of the art in technological and non-technological approaches, CO-FRESH proposes to develop techniques, tools and insights for the re-design of agri-food value chains. Through collaborative and systemic approaches, the tools and formats will be applied in 7 pilot cases representing diverse fruit and vegetables agri-food value chains (including protein crops for food and feed) across Europe. CO-FRESH will use the Intervention Research approach to study models of collective innovation action within and across organisations. The CO-FRESH consortium brings together key actors from pilot agri-food value chains; actors’ associations (farmers, food producers, cooperatives, consumers); experts in technological (including digital) solutions and non-technological (including social, organizational, and institutional) solutions; as well as experts in environmental, social, economic sustainability, and in consumer’s acceptance. The main objective of CO-FRESH is to (re)design and pilot innovative systemic approaches to agri-food value chains to scale up this innovation at European level. These innovative approaches will improve economic, social and environmental performance/efficiency of these value chains, through smart integration of technological, social, organisational, managerial and institutional innovations; all of which serve to make them more sustainable. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_e20b00c818e2fb7a11340dd1d9802040 | Next Generation Earth Modelling Systems | European Commission | Barcelona Supercomputing Center - Centre Nacional de Supercomputació (BSC-CNS) | CORDIS-101003470 | NextGEMS will develop and apply a new generation of global coupled Storm-Resolving Earth System Models (SR-ESMs) to the study of anthropogenic climate change. SR-ESMs are distinguished by their fine, 3 km, grid in the atmosphere and ocean. This allows a more physical representation of atmospheric and oceanic circulation systems, including their coupling to Earth-system processes such as the carbon, nutrients, water and atmospheric particulate (aerosol) cycles. NextGEMS will develop two prototypes SR-ESMs into production systems and produce multi-decadal (30 y) projections of future climate change. Improved resolution is expected to reduce biases and enhance the realism of these simulations. Ensembles of simulations will address scientific puzzles such as the impact of convective organization on climate sensitivity, the magnitude of aerosol forcing, and the changes in extremes associated with tropical air-sea interaction (including the African Monsoon and Atlantic Hurricanes) and land-surface interaction in the mid-latitudes (dry-spells and links between hydrology and carbon). By developing models that are structurally different than existing ones, NextGEMS will reshape perceptions of uncertainty and provide a basis for reassessing the risk global warming poses for society and ecology. By focusing on just two models, NextGEMS builds a European community of scientists and users around a technologically more ambitious modelling enterprise. This concentration is needed if Europe is to maintain its position at the forefront of Earth-system modelling. By representing the scales of motion and driving forces of high impact weather globally, NextGEMS links more directly to applications, thereby shortening the value chain. Knowledge coproduction projects focusing on how circulation influences both solar energy production and marine nutrients will demonstrate how applications and downstream users can thus be directly integrated into the model development enterprise. | H2020-EU.3.5. / 3.5 Societal Challenges - Climate | 6project_grants_public |
gen_f1213c457b81e24322f0ddfdaa28e9f4 | A global approach for recovery of arable land through improved phytoremediation coupled with advanced liquid biofuel production and climate friendly copper smelting process | European Commission | ITS FORDERBERATUNG GMBH | CORDIS-101006912 | Phy2Climate will validate 5 phytoremediation pilots in Spain (South Europe), Serbia (Balkan region), Lithuania (Baltic region), Argentina (South America) and India (South Asia) at TRL-5. The selected contaminated sites represent the most common soil contaminants worldwide. The phytoremediation pilots will produce energy crops with none indirect Land Use Change (iLUC) issues. The energy crops will feed a pilot biorefinery in Germany that combines cutting edge biomass processing technologies to produce 4 types of clean drop-in biofuels for the road and shipping transport sectors at TRL-5: EN 14214 biodiesel, ISO 8217 marine fuels, EN 590 diesel and EN 228 gasoline. Additionally, bio-coke will be also produced as substitution of petroleum coke in the metallurgical industry. A significant cost reduction in factor >5 for phytoremediation compared with common remediation techniques is target together with conversion costs of drop-in biofuel production <0,45 €/l. The global biofuel production potential of the Phy2Climate approach is estimated up to 137 million m3 per year. Furthermore, estimated specific Greenhouse Gas (GHG) mitigation of the produced drop-in biofuels is 149% compared with the fossil equivalents, resulting in a total saving potential of 500 Mega-tones CO2eq per year. The work programme is divided in 7 work packages that are specifically designed to achieve the objectives of the project as well as to contribute to the Mission Innovation Challenge 4 and to 16 UN Sustainable Development Goals. The Phy2Climate consortium unites 17 partners from 10 different countries with strong interdisciplinary expertise in the fields of project management, soil remediation & phytoremediation, advanced biofuel technologies, environmental and social sustainability, legal analysis, business development and communication &dissemination. Additionally 11 stakeholders from 8 countries and at EU level have already expressed their interest in the project by a letter of support. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_466c09306a36d3c08193c9b680644e37 | Connecting European Cohorts to Increase Common and Effective Response to SARS-CoV-2 Pandemic: ORCHESTRA | European Commission | CBCI Society for Medical Education | CORDIS-101016167 | The ORCHESTRA project provides an innovative approach to learn from the SARS-CoV-2 health crisis and derive recommendations for increasing preparedness for future outbreaks. The main outcome of the project is the creation of a new pan-European cohort built on existing and new large-scale population cohorts in European and non-European countries. Data analysis through a federated learning technique supported by advanced modelling capabilities will allow the integration of epidemiological, clinical, microbiological and genotypic aspects of population-based cohorts with environment and socio-economic features. The ORCHESTRA cohort will include SARS-CoV-2 infected and non-infected individuals of all ages and conditions and thereby enabling a retrospective evaluation of risk factors for the disease acquisition and progression of the disease and prospective follow-up aimed at exploring long term consequences and analysis of vaccination response. To better address these research questions, the ORCHESTRA-cohort will include adequately sampled representatives of general populations, COVID-19 patients and special ‘at risk’ populations of fragile individuals and health-care workers. The project aims also to evaluate how the acquisition of SARS-CoV-2 variants impacts on the severity of disease. ORCHESTRA will specifically assess the immunity function status in vaccinated and not vaccinated health care workers, including assessment in-between the first and the second dosages of any available vaccine and explore differences in level and durability of antibody immune responses and frequency of breakthrough infections (symptomatic and asymptomatic) in fragile population (e.g oncological, transplanted, hematological, HIV-infected and suffering from Parkison disease). The understanding of the evoked immune response by population, variants and type of vaccine are key to better understand how vaccines againstSARS-CoV-2 variants can prevent transmission and severe SARS-CoV-2 infections, why certain variants may be able to escape vaccines, and whether refresher boosters at regular intervals could change any of these outcomes. The participation of non-European and Low-Medium Income Countries and a Global COVID-19 Guidance group of major stakeholders and investigators from successful clinical trials addressing therapeutic approaches to COVID-19, ensures inclusion of all expertise needed and translation of recommendations to different social and economic settings. The project will significantly impact on the responsiveness to SARS-CoV-2 and can be used as a model for responsiveness for new public health threats. | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_3a18075c25a37116049afba36c1ae4db | A Collaborative Paradigm for Human Workers and Multi-Robot Teams in Precision Agriculture Systems | European Commission | Università degli Studi Roma Tre | CORDIS-101016906 | In CANOPIES, our goal is to develop a novel collaborative human-robot paradigm addressing the challenges of Human Robot Interaction and Human-Robot Collaboration in the unstructured highly dynamic outdoor environment of permanent crop farming (Agri-Food Area). Our approach will be demonstrated through an integrated system composed by farming robots and logistics robots with a real-world validation of two economically relevant agronomic operations within a table-grape vineyard: harvesting and pruning. CANOPIES represents the first attempt to introduce a collaborative paradigm in the field of precision agriculture for permanent crops where farmworkers can efficiently work together with teams of robots to perform agronomic interventions, like harvesting or pruning in table-grape vineyards. Both operations require complex processes of perception, communication, shared planning in agreement, prediction of human intentions, interaction and action. But also, both agronomic operations should be done in real life conditions, that is, in changing illumination and cast shadows, changing agronomic situations, where the vine branches or grapes can make it difficult to harvest or prune in a safe manner, due to the robot physical proximity to the human, while operating in real time. CANOPIES ambition will be achieved by introducing: i) novel human-robot interaction methodologies for enhanced safety and coexistence, ii) novel human-robot collaboration methodologies for increased system adaptability and intuitive usability; iii) novel multi-robot coordination methodologies for improved scalability. CANOPIES impact will contribute to filling the current gap in the development of fully autonomous robotic solutions for permanent crops by introducing a novel concept of farming robots, where we leverage an effective interaction with the human workers to mitigate the greater complexity of permanent crops as compared with field crops. | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 6project_grants_public |
gen_eccacd0b545097f781edf4ba5868e31a | Secure and Safe Multi-Robot Systems | European Commission | University of Cyprus; CAVES KOX SARL | CORDIS-101017258 | European strategy and research roadmap documents emphasise the significant societal and economic benefits coming from robotic and autonomous systems. Multi-Robot Systems (MRS) comprise distributed and interconnected robotic teams that can carry out tasks beyond the competency of a single robot. Although MRS offer improved scalability and performance, increased robustness, and mission enablement, the lack of a systematic engineering methodology, covering the complete engineering lifecycle and handling efficiently the salient characteristics of MRS such as openness, uncertainty, variability, and interplay of safety and security, results in solutions that fail because of fragile design and unrealistic assumptions. SESAME addresses these problems through an open, modular, model-based approach for the systematic engineering of dependable MRS. SESAME is underpinned by public meta-models, components and configuration tools supporting the dependable MRS operation in uncertain settings characterised by emergent behaviours and possible cyber-attacks. To demonstrate this timely and ambitious goal, SESAME combines five end- user-led use-cases (in the domains of healthcare, agile manufacturing, agri-food, and inspection and maintenance) with R&D competences of partners that have a long track-record in conducting cutting-edge research on robotics, model- based safety, security analysis, validation, and verification, towards the actual delivery of research results characterised by widely-used, sustainable and industrial-strength open-source software. An advisory board of world-class experts guides the development of SESAME . | H2020-EU.2.1.1. / 2.1.1 LEIT - ICT | 6project_grants_public |
gen_1d4c23523b2336c2a2c2b3e8c5aaa43c | Knowledge At the Tip of Your fingers: Clinical Knowledge for Humanity | European Commission | Eurecat, centre tecnològic de Catalunya | CORDIS-101017453 | AI-empowered Personalized Medicine promises to find tailored, targeted, nearly “hand-made” cures for patients. Cancer treatment desperately needs boosters to find tailored, targeted cures for patients and Personalized Medicine can play a crucial role. Tailored targeted therapies in cancer treatment are already a reality but the current practice of targeted therapies in cancer treatment has been derived with traditional methods of data analysis. AI-empowered Personalized Medicine may help to bring targeted therapies to the next level. However, no matter how precise it is, no matter how many lives it can save in principle, and no matter if it can utilize the entire medical knowledge. If clinicians do not understand its suggestions and decisions, AI-empowered Personalized Medicine will not be a game changer, clinicians will not use it to make everyday decisions and, thus, it is doomed to fail. Hence, the real challenge is building AI-empowered Personalized Medicine systems that can be accepted by clinicians and clinical researchers. In KATY, we grasp the above challenge and we propose an AI-empowered Personalized Medicine system that can bring medical “AI-empowered knowledge” to the tips of the fingers of clinicians and clinical researchers. The AI-empowered knowledge is a human interpretable knowledge that clinicians and clinical researchers can: understand, trust and effectively use in their everyday working routine. KATY is then a AI-empowered Personalized Medicine system built around two main components: A Distributed Knowledge Graph and A pool of eXplainable Artificial Intelligence predictors. As a stress test and due to the lack of personalized clinical responses, KATY will be experimented in a low prevalence and complex cancer: Clear cell renal cell carcinoma (ccRCC). | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_28a7b057298ef49ee3d7ffa98a245fde | Secure management of IoT devices lifecycle through identities, trust and distributed ledgers | European Commission | IDIADA, Automotive Technology | CORDIS-101020416 | ERATOSTHENES will devise a novel distributed, automated, auditable, yet privacy-respectful, Trust and Identity Management Framework intended to dynamically and holistically manage the lifecycle of IoT devices, strengthening trust, identities, and resilience in the entire IoT ecosystem, supporting the enforcement of the NIS directive, GDPR and Cybersecurity Act. ERASTOSTHENES will leverage breakthrough solutions: (a) the first-ever enclosure of cybersecurity features in IoT devices through deployment of Trust Agents and continuous trust evaluation within the network in a contextual and social approach; (b) decentralised identity management mechanisms to conciliate requirements of self-sovereignty and privacy preservation in a distributed/transparent trust model along with disposable identities; (c) self-encryption/decryption at device-level with a whole system automated recovery process (incl. software, crypto-key material, identities) after an attack based on a multi-layer recovery model; (d) threat-analysis models based on federated learning and edge execution to continuously monitor devices and detect attacks; (e) collaborative IoT threat intelligence sharing across ledgers to adapt detection/defense mechanism to the evolving security conditions and assist the IoT life-cycle; (f) integration of Physical Unclonable Functions in trust framework and distributed ledgers. Finally, it will support enforcement of the NIS directive with a security information sharing mechanism based on inter-ledger technologies to support exchange of trust and security information among stakeholders, enhancing collaboration, vulnerabilities’ disclosure, and secure management of software updates. The overall vision of ERATOSTHENES is to provide core cybersecurity features to be adopted by manufacturers as baseline certification elements in the production of devices and throughout their entire lifecycle. The solution will be validated in 3 industrial cases: Automotive, Health, Industry 4.0. | H2020-EU.3.7. / 3.7 Societal Challenges - Secure societies | 6project_grants_public |
gen_7407eab0d1237290f408d131fd4095ac | Next-Generation Integrated Energy Services fOr Citizen Energy CommuNities | European Commission | INSTITUT MIHAJLO PUPIN | CORDIS-101033700 | While building on results of recently (or soon to be) concluded EU projects, NEON will undertake coordination and support activities to advance the leveraging technologies and concepts in order to deliver the next-generation integrated energy services for communities, targeted to enhance the life quality of European citizens, while improving the performance of energy system. In this endeavour, NEON will exploit building energy efficiency, renewable energy generation and storage, and demand flexibility to increase energy savings, reduce CO2 emissions, and provide cost savings across sectors. NEON will engage grid stakeholders, service providers and final consumers to establish, in co-creation, the cross-sectoral arrangements and underlying service concepts. NEON will join multi-measure energy efficiency interventions and advanced control capabilities to maximize the positive impact of energy efficiency by improving the building operation performance and make the demand-side flexibility as manageable and procurable resource. NEON will advance the energy efficiency services already available on the market and couple them with other energy services and non-energy benefits, providing an integrated approach to energy generation, storage and consumption management. To enable servitization of proposed concepts, NEON will bring innovative business and contracting models by integrating EPC with P4P schemes, and establish innovative M&V methodology. The concept of Citizen Energy Communities (CECs), as introduced by Directive (EU) 2019/944, will be leveraged to set the legal and business foundations to enable faster market uptake, and facilitate communities, both residential and non-residential, in becoming energy-efficient. The proposed service concepts and business models will be showcased in 4 CEC setups (residential, non-residential and mixed) serving as early adopters, whereby follow-up replication plans across 7 “follower” communities will be developed during the project. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_491ad22fd48d9c34480c9cb1a5d9175c | Clinical evaluation of carbons of controlled porosity as a new therapeutic for the treatment of liver cirrhosis and non-alcoholic fatty liver disease. | European Commission | Fundació Institut de Recerca Hospital Universitari Vall d’Hebron (FIR-HUVH); AZIENDA OSPEDALE-UNIVERSITÀ PADOVA | CORDIS-634579 | Chronic liver disease affects about 29-million Europeans accounting for about 170,000 deaths at a cost of around €15.8bn. This chronic non-communicable disease is increasing at an alarming rate due to increasing European obesity, alcohol use and ageing. The three main causes of the disease; alcohol, fatty liver and viral hepatitis are amenable to prevention and treatment. Gut-derived endotoxins and bacterial translocation are central factors implicated in the pathogenesis of fatty liver disease and, the development and progression of cirrhosis. In cirrhosis, current state-of-the-art therapy to prevent recurrent complications of advanced cirrhosis is to use poorly absorbed antibiotics but long-term antibiotic therapy has problems associated with bacterial resistance, infection with resistant organisms and the cost. Treatment of fatty liver and modulation of bacterial translocation in early cirrhosis to prevent complications is an unmet need. Our academic-industrial consortium has developed a novel, patented, safe and cheap nanoporous carbon that modulates the effects of bacterial translocation in animal models of liver disease. Our feasibility studies demonstrate that this product advances the current state-of-the-art, is a TRL 4/5 and is now ready for validation through clinical trials. We propose to investigate the safety and efficacy of this novel nanoporous carbon in patients with fatty liver disease and cirrhosis. If successful, we will be able to confirm an innovative, cost-effective and novel strategy for the management of this chronic disease in a European population. Exploitation of the results of the CARBALIVE project will support the continued development of this carbon through additional private and public sector investment. The use of this innovative therapy is expected to reduce the economic burden of the disease in Europe, allow patients to achieve enhanced quality of life, improve survival, and allow many patients to return to economic productivity. | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_0dc1aa9394ba191f8ba17ed7a7f2d202 | Novel marine biomolecules against biofilm. Application to medical devices. | European Commission | KTEDOGEN SRL | CORDIS-634588 | Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 € per infection episode. Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice. For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models. This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems. Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_8be4b443f1ece6d5d837d7edc4094e94 | Novel photo-assisted systems for direct Solar-driven redUctioN of CO2 to energy rich CHEMicals | European Commission | SOLINTEL M&P SL | CORDIS-884444 | Gathering 15 partners from 9 European and associated countries and 3 from Asian countries, SUN2CHEM’s main objective is to develop solutions to achieve efficient solar-driven CO2 reduction, targeting ethylene as the final product. Ethylene, an energy-rich chemical produced from fossil fuels in industry, has both high commercial value and a giant global market. SUNCHEM’s ambitions will simultaneously reduce our dependence on fossil fuels and mitigate carbon emission by CO2 conversion. For that purpose, SUN2CHEM partners will conjointly develop all the components to be integrated into tandem photoelectrochemical (PEC) cells and advanced photocatalytic (PC) reactors. The technical part of this project includes applied and fundamental research on photocatalysis to improve light-harvesting and charge separation in heterojunctions and plasmonic bimetallic nanoparticles united in a PC reactor (WP2). Next WPs focus on the development of up-scalable efficient and stable photoelectrodes (WP3) and the design of earth-abundant catalysts (WP4), which will then be integrated into the tandem PEC (WP5). Both PC reactor and PEC device will be tested and characterised in operating conditions (WP6). In addition to this highly technical core, this project has for ambition to perform related environmental and social studies in order to integrate the developed technology within a context of circular economy, assess the energy security impacts on end-users and increase the social acceptance of chemicals produced from sunlight conversion (WP7). A prospective market analysis and roadmap towards the upscaling of the technology will then evaluate its medium-term potential and establish pathways towards its future industrial development (WP8). Achieving these ambitious developments by tackling photo-electrochemical cells, catalysts for CO2 reduction, light-harvesting and charge separation, SUN2CHEM will contribute answering Mission Innovation’s Converting Sunlight Innovation Challenge. | H2020-EU.3.3. / 3.3 Societal Challenges - Energy | 6project_grants_public |
gen_7b61364637c083d7cc9ead75a96f7ec0 | Resource Efficient Food and dRink for the Entire Supply cHain | European Commission | ALL-CHINA ENVIRONMENT FEDERATION | CORDIS-641933 | The overall aim of the REFRESH project is to contribute significantly towards the objective of reducing food waste across the EU by 30% by 2025 (which amounts to between 25 to 40 million tonnes of food not being wasted in 2025[1], worth tens of billions of Euros a year) and maximizing the value from unavoidable food waste and packaging materials. To achieve this ambitious goal, we will adopt a systemic approach and use cutting edge science to enable action by businesses, consumers and public authorities. A central ambition of the REFRESH project is to develop a ‘Framework for Action’ model that is based on strategic agreements across all stages of the supply chain (backed by Governments), delivered through collaborative working and supported by evidence-based tools to allow targeted, cost effective interventions. Success will support transformation towards a more sustainable and secure EU food system, benefitting Europe’s economy, environment and society. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_d924ac0a025f02b71bd378c52aad1c79 | NANOmaterials for the REStoration of works of ART | European Commission | THE BOARD OF TRUSTEES OF THE TATE GALLERY | CORDIS-646063 | Currently there is a lack of methodologies for the conservation of modern and contemporary artworks, many of which will not be accessible in very short time due to extremely fast degradation processes. The challenge of NANORESTART (NANOmaterials for the REStoration of works of ART) will be to address this issue within a new framework with respect to the state of the art of conservation science. NANORESTART is devoted to the development of nanomaterials to ensure long term protection and security of modern/contemporary cultural heritage, taking into account environmental and human risks, feasibility and materials costs. The market for conservation of this heritage is estimated at some €5 billion per year, and could increase by a significant factor in the next years due to the wider use of nanomaterials. The new tools and materials developed will represent a breakthrough in cultural heritage and conservation science and will focus on: (i) tools for controlled cleaning, such as highly-retentive gels for the confinement of enzymes and nanostructured fluids based on green surfactants; (ii) the strengthening and protection of surfaces by using nanocontainers, nanoparticles and supramolecular systems/assemblies; (iii) nanostructured substrates and sensors for enhanced molecules detection; (iv) evaluation of the environmental impact and the development of security measures for long lasting conservation of cultural heritage. Within the project the industrial scalability of the developed materials will be demonstrated. NANORESTART gathers centres of excellence in the field of synthesis and characterization of nanomaterials, world leading chemical Industries and SMEs operating in R&D, and International and European centres for conservation, education and museums. Such centres will assess the new materials on modern/contemporary artefacts in urgent need of conservation, and disseminate the knowledge and the new nanomaterials among conservators on a worldwide perspective. | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 6project_grants_public |
gen_141e3658e3909088e0e2c303327d7b56 | HIGH SPECIFIC ENERGY ALUMINIUM-ION RECHARGEABLE DECENTRALIZED ELECTRICITY GENERATION SOURCES | European Commission | ACCIONA INFRAESTRUCTURAS S.A. | CORDIS-646286 | The overall objective of the ALION project is to develop aluminium-ion battery technology for energy storage application in decentralised electricity generation sources. ALION pursues an integral approach comprising electroactive materials based on “rocking chair” mechanism, robust ionic liquid-based electrolytes as well as novel cell and battery concepts, finally resulting in a technology with much lower cost, improved performance, safety and reliability with respect to current energy storage solutions (e.g. Pumped hydro storage, Compressed air energy storage, Li-ion battery, Redox Flow Battery...). The project covers the whole value chain from materials and component manufacturers, battery assembler, until the technology validation in specific electric microgrid system including renewable energy source (i.e. mini wind turbine, photovoltaic system…). Thus, the final objective of this project is to obtain an Al-ion battery module validated in a relevant environment, with a specific energy of 400 W.h/kg, a voltage of 48V and a cycle life of 3000 cycles. | H2020-EU.2.1.3. / 2.1.3 LEIT - Advanced materials | 0business_rnd_innovation |
gen_5fd6db3536d08e36a7d0c41c303137e9 | An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century | European Commission | F. Hoffmann-La Roche AG; BIOTALENTUM TUDASFEJLESZTO KFT | CORDIS-681002 | The vision of EU-ToxRisk is to drive a paradigm shift in toxicology towards an animal-free, mechanism-based integrated approach to chemical safety assessment. The project will unite all relevant disciplines and stakeholders to establish: i) pragmatic, solid read-across procedures incorporating mechanistic and toxicokinetic knowledge; and ii) ab initio hazard and risk assessment strategies of chemicals with little background information. The project will focus on repeated dose systemic toxicity (liver, kidney, lung and nervous system) as well as developmental/reproduction toxicity. Different human tiered test systems are integrated to balance speed, cost and biological complexity. EU-ToxRisk extensively integrates the adverse outcome pathway (AOP)-based toxicity testing concept. Therefore, advanced technologies, including high throughput transcriptomics, RNA interference, and high throughput microscopy, will provide quantitative and mechanistic underpinning of AOPs and key events (KE). The project combines in silico tools and in vitro assays by computational modelling approaches to provide quantitative data on the activation of KE of AOP. This information, together with detailed toxicokinetics data, and in vitro-in vivo extrapolation algorithms forms the basis for improved hazard and risk assessment. The EU-ToxRisk work plan is structured along a broad spectrum of case studies, driven by the cosmetics, (agro)-chemical, pharma industry together with regulators. The approach involves iterative training, testing, optimization and validation phases to establish fit-for-purpose integrated approaches to testing and assessment with key EU-ToxRisk methodologies. The test systems will be combined to a flexible service package for exploitation and continued impact across industry sectors and regulatory application. The proof-of-concept for the new mechanism-based testing strategy will make EU-ToxRisk the flagship in Europe for animal-free chemical safety assessment. | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_3c1cbabc32df15e653615eae23137b22 | Exploring the use of CDK4/6 inhibitors in combination with classical chemotherapy | Worldwide Cancer Research | Spanish National Cancer Research Centre | HRCS22_14416 | No abstract available for this analysis. | No Research Activity assigned | 6project_grants_public |
gen_7c11f24ca95c17f9b5cf5e5991641d82 | Sustainable techno-economic solutions for the agricultural value chain | European Commission | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. ; EKO KVARNER ORGANIZATION | CORDIS-690142 | Continuing population and consumption growth are driving global food demand, with agricultural activity increasing to keep pace. Europe has a major agricultural waste problem, generating some 700 million tonnes of waste annually. There is an urgent need and huge opportunity to address the efficient use of agricultural wastes, co-products and by-products (AWCB) towards delivering sustainable value chains in the farming and processing sectors. As such, AgroCycle will convert low value agricultural waste into highly valuable products, achieving a 10% increase in waste recycling and valorisation by 2020. This will be achieved by developing a detailed and holistic understanding of the waste streams and piloting a key number of waste utilisation/valorisation pathways. It will bring technologies and systems from ~TRL4 to ~TRL7 within the 3 years of the project. A post-project commercialisation plan will bring commercially promising technologies/systems to TRL8 and TRL9, ensuring AgroCycle will have an enduring impact by achieving sustainable use of AWCB both inside and outside the agricultural sector, leading to the realisation of a Circular Economy. AgroCycle addresses wastes from several agricultural sectors: wine, olive oil, horticulture, fruit, grassland, swine, dairy and poultry. The AgroCycle consortium is a large (25) multi-national group (including China) comprising the necessary and relevant multi-actors (i.e. researchers; companies in the technical, manufacturing, advisory, retail sectors (Large and SMEs); lead users; end users; and trade/producer associations) for achieving the project’s ambitions goals. Farming’s unique regional (rural) location means that AgroCycle will help reduce the EU’s Innovation Divide and address the Regional Smart Specialisation Strategies for each partner country: impact will be Regional with National and International dimensions. The presence of three partners from China ensures international synergies and a global impact. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_84f21977f13c638622d5c08b846b8fb1 | MIDDLE EAST AND NORTH AFRICA REGIONAL ARCHITECTURE: MAPPING GEOPOLITICAL SHIFTS, REGIONAL ORDER AND DOMESTIC TRANSFORMATIONS | European Commission | EGMONT-INSTITUT ROYAL DES RELATIONS INTERNATIONALES | CORDIS-693244 | The ‘Middle East and North Africa Regional Architecture: mapping geopolitical shifts, regional order and domestic transformations’ -the MENARA Project- will study the geopolitical order in the making in the South and East Mediterranean Countries and the Middle East amid all deep-reaching social and political changes unfolding since 2010. The project aims at describing the main features of the regional geopolitical order, its origins, and evolution; identifying and mapping the decisive domestic, regional and global actors, dynamics and trends; building future scenarios for 2025 and 2040; and informing EU policies and strategies. It will examine whether, where and when conflict and/or cohesion dynamics prevail, the level and depth of regional fragmentation and the effects of regional and domestic processes on global dynamics and vice versa. This will be achieved by analysing ideational and material factors (national, sub and supra-national identities; religion and politics; global identities; demography; energy; economy; military; environment) and by conducting in-depth research on specific case studies on ongoing dynamics at three different levels (domestic, regional and global). All this research will be based on quantitative and qualitative methods -including fact finding missions on the ground, interviews, focus groups, Delphi surveys - and innovative foresight techniques. Research will be accompanied by pioneering dissemination methods willing to increase the project’s impact not only over the specific academic community and policy-making circles but also over broader general public. This will include the translation of research results into accessible deliverables such as audio-visuals, futures notes series, infographics and interactive maps, and a Massive Open Online Course. | H2020-EU.3.6. / 3.6 Societal Challenges - Europe in a changing world | 6project_grants_public |
gen_5068b8968b8b0ccb85cb4447103a1977 | Agri and food waste valorisation co-ops based on flexible multi-feedstocks biorefinery processing technologies for new high added value applications | European Commission | STAZIONE SPERIMENTALE PER L'INDUSTRIA DELLE CONSERVE ALIMENTARI | CORDIS-720719 | Approximately one third of all food produced globally is wasted every year throughout the whole value chain-from farmers to consumers. To extract the significant amounts of valuable compounds contained in these wastes, AgriMax will combine affordable and flexible processing technologies (ultrasound assisted and solvent extraction, filtration, thermal and enzymatic treatments) for the valorization of side streams from the horticultural culture and food processing industry to be used in a cooperative approach by local stakeholders. Through the selection of case-scenarios previously developed to a pilot scale by the participating RTOs and their industrial transfer in new applications as food additives, packaging and agricultural materials among others, the project will disclose the holistic potential of four new agro-value chains (residues and by products from the culture and processing of tomato, cereals, olives, potato). Any by-product generated along the production cycle will be valorized in a cascade manner to reach over 40% of high value use of the waste. This will lead to additional production of active ingredients in lower concentration, but also fibres, biogas and fertilizers from the left biomass (the latter with the aim of being used in closed loop in the culture of the crops used in the project to prevent soil impoverishing). An LCA and LCC will also study the best approach to minimize the environmental impact of the new value chains without jeopardizing the cost effectiveness of the operations. The pilot multi-feedstock bio-refinery processes will be validated in two demonstration sites in Spain and Italy. Societal, ethical, safety, techno-feasibility and regulatory aspects will be studied. Last but not least, a business model and platform for communication between the potential raw materials suppliers will be set up to maximize the use of the cooperative treatment plants throughout the year. | H2020-EU.3.2. / 3.2 Societal Challenges - Food | 6project_grants_public |
gen_3f07134e4244c4fd4b9b6b19b39ebd7c | Compositional security certification for medium- to high-assurance COTS-based systems in environments with emerging threats | European Commission | UNICONTROLS A.S.; Technikon Forschungs- und Planungsgesellschaft mbH | CORDIS-731456 | certMILS develops a security certification methodology for Cyber-physical systems (CPS). CPS are characterised by safety-critical nature, complexity, connectivity, and open technology. A common downside to CPS complexity and openness is a large attack surface and a high degree of dynamism that may lead to complex failures and irreparable physical damage. The legitimate fear of security or functional safety vulnerabilities in CPS results in arduous testing and certification processes. Once fielded, many CPS suffer from the motto: never change a running system. certMILS increases the economic efficiency and European competitiveness of CPS development, while demonstrating the effectiveness of safety & security certification of composable systems. The project employs a security-by-design concept originating from the avionics industry: Multiple Independent Levels of Security (MILS), which targets controlled information flow and resource usage amongst software applications. certMILS reduces certification complexity, promotes re-use, and enables secure updates to CPS throughout its life-cycle by providing certified separation of applications, i.e. if an application within a complex CPS fails or starts acting maliciously, other applications are unaffected. Security certification of complex systems to medium-high assurance levels is not solved today. The existing monolithic approaches cannot cope with the complexity of modern CPS. certMILS uses ISO/IEC 15408 and IEC 62443 to develop and applies a compositional security certification methodology to complex composable safety-critical systems operating in constantly evolving hostile environments. certMILS core results are standardised in a protection profile.certMILS develops three composable industrial CPS pilots (smart grid, railway, subway), certifies security of critical re-useable components, and ensures security certification for the pilots by certification labs in three EU countries with involvement of the authorities. | H2020-EU.3.7. / 3.7 Societal Challenges - Secure societies | 6project_grants_public |
gen_e8ab711b9378407586b5778b43599958 | Towards evidence-based tailored implementation strategies for eHealth | European Commission | EUROPEAN ALLIANCE AGAINST DEPRESSION EV | CORDIS-733025 | ImpleMentAll will develop, apply, and evaluate tailored implementation strategies in the context of on-going eHealth implementation initiatives in the EU and beyond. Common mental health disorders account for an alarming proportion of the global burden of disease. Being regarded as an evidence-based psychotherapeutic eHealth intervention, Internet-based Cognitive Behavioural Therapy (iCBT), has the potential to answer to this societal challenge by providing an efficacious and efficient treatment from which more people can benefit. As a result, various iCBT implementation projects are currently conducted across the world. We propose to use this natural laboratory to develop and evaluate a toolkit for tailored implementation strategies that is expected to make implementation trajectories more efficient. The objectives for ImpleMentAll are: 1) To develop a generic Integrated Theory-based Framework for Intervention Tailoring Strategies (the ItFits-toolkit) for data-driven tailored implementation of evidence-based eHealth services. 2) To demonstrate the impact of the ItFits toolkit on the implementation of eHealth for common mental disorders, in 9 European countries, 2 LMIC, and Australia. 3) To disseminate the validated toolkit in various healthcare contexts across Europe. ImpleMentAll is a true multidisciplinary international collaboration that unites key experts in clinical practice, health innovation, clinical research, and implementation science. Combined with it’s unique setup, ImpleMentAll will be able to test if tailoring implementation strategies lead to more efficient implementation. The resulting ItFits-toolkit will enable data driven evaluation of eHealth implementation projects in terms key performance indicators for process, effectiveness, and efficiency outcomes. Its methods, materials, and strategies will provide concrete guidance on tuning implementation interventions to local determinant of practice across a variety of health care systems. | H2020-EU.3.1. / 3.1 Societal Challenges - Health | 6project_grants_public |
gen_257330bf2e775523fe99b873542b0d75 | Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream | European Commission | University of Birmingham | CORDIS-734522 | The overall vision of INTERWASTE is to develop scientific understanding of issues related to environmental contamination with toxic organic chemicals (specifically flame retardants (FRs) and pharmaceutical and personal care products (PPCPs)) arising from their presence in the waste stream. Specific research objectives include: (a) exchange of knowledge of and best practice in methods for rapid and cost-effective identification of waste items containing restricted FRs; (b) developing scientific understanding of environmental contamination due to processing of waste items containing FRs; and (c) furthering understanding of the sources of PPCPs and FRs in the sewerage system. To facilitate such research on the global level required, INTERWASTE will exchange best practice in the analytical chemistry techniques required to study FRs and PPCPs, and evaluate the measurement capability of INTERWASTE participants via an interlaboratory comparison. INTERWASTE's vision will be achieved via a co-ordinated programme of collaboration and research secondments between world-leading research groups both within and outside the EU; coupled with annual workshops to discuss the latest findings. The research programme will exploit the complementary expertise of the consortium members, and in so doing foster synergies. Cross-sectoral interaction and knowledge sharing will be achieved via the participation of beneficiaries and partner organisations from both academic and non-academic sectors. All secondments and workshops will be conducted within a framework designed to maximise the training and career development benefits to participating staff by providing them with opportunities for knowledge and skills acquisition, with a particular (but not exclusive) focus on early career researchers. INTERWASTE's research and training programme is complemented by communication activities that will both disseminate project findings to scientific stakeholders, and engage the general public. | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 6project_grants_public |
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