DOI stringlengths 13 47 | Year int64 2.01k 2.02k | Journal stringlengths 3 170 | Title stringlengths 1 281 ⌀ | Abstract stringlengths 14 62.9k ⌀ | Full Text stringlengths 22 5M |
|---|---|---|---|---|---|
10. 1002/adhm. 201500728 | 2,016 | Advanced healthcare materials | Tuning Reaction and Diffusion Mediated Degradation of Enzyme-Sensitive Hydrogels | Enzyme-sensitive hydrogels are promising for cell encapsulation and tissue engineering, but result in complex spatiotemporal degradation behavior that is characteristic of reaction-diffusion mechanisms. An experimental and theoretical approach is presented to identify dimensionless quantities that serve as a design too... | No full text available |
10. 1002/adhm. 201500892 | 2,016 | Advanced healthcare materials | Poly(limonene thioether) Scaffold for Tissue Engineering | A photocurable thiol-ene network polymer, poly(limonene thioether) (PLT32o), was synthesized, characterized, fabricated into tissue engineering scaffolds, and demonstrated in vitro and in vivo. Micromolded PLT32o grids exhibited compliant, elastomeric mechanical behavior similar to grids made of poly(glycerol sebacate)... | No full text available |
10. 1002/adhm. 201600136 | 2,017 | Advanced healthcare materials | Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds | Collagen I foams are used in the clinic as scaffolds to promote articular cartilage repair as they provide a bioactive environment for cells with chondrogenic potential. However, collagen I as a base material does not allow for precise control over bioactivity. Alternatively, recombinant bacterial collagens can be used... | 1 Introduction Articular cartilage is a highly complex and dynamic connective tissue that covers the surfaces of bones in synovial joints, [ 1 ] where it provides a low-friction, wear-resistant surface and contributes to load transmission to the underlying subchondral bone. [ 2 ] The unique biochemical microenvironment... |
10. 1002/adhm. 201600181 | 2,016 | Advanced healthcare materials | The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials | The tendon-bone junction (TBJ) is a unique, mechanically dynamic, structurally graded anatomical zone which transmits tensile loads between tendon and bone. Current surgical repair techniques rely on mechanical fixation and can result in high re-failure rates. We have recently described a new class of collagen biomater... | No full text available |
10. 1002/adhm. 201600699 | 2,017 | Advanced healthcare materials | Pericyte seeded dual peptide scaffold with improved endothelialization for vascular graft tissue engineering | The development of synthetic vascular grafts for coronary artery bypass is challenged by insufficient endothelialization, which exposes to the risk of thrombosis, and lack of native cellular constituents, which favours pathological remodelling. Here, an bifunctional electrospun poly(ε-caprolactone) (PCL) scaffold with ... | No full text available |
10. 1002/adhm. 201600820 | 2,016 | Advanced healthcare materials | Local delivery of PHD2 siRNA from ROS-degradable scaffolds to promote diabetic wound healing | siRNA delivered from ROS-degradable tissue engineering scaffolds promotes diabetic wound healing in rats. Porous poly(thioketal-urethane) (PTK-UR) scaffolds implanted in diabetic wounds locally deliver siRNA that inhibits the expression of prolyl hydroxylase domain protein 2 (PHD2), thereby increasing the expression of... | No full text available |
10. 1002/adhm. 201601225 | 2,017 | Advanced healthcare materials | Biofunctionalized plants as diverse biomaterials for human cell culture | The commercial success of tissue engineering products requires efficacy, cost effectiveness and the possibility of scale-up. Advances in tissue engineering require increased sophistication in the design of biomaterials, often challenging our current manufacturing techniques. Interestingly, several of the properties tha... | No full text available |
10. 1002/adhm. 201601451 | 2,017 | Advanced healthcare materials | Extrusion Bioprinting of Shear-Thinning Gelatin Methacryloyl Bioinks | Bioprinting is an emerging technique for the fabrication of three-dimensional (3D) cell-laden constructs. However, the progress for generating a 3D complex physiological microenvironment has been hampered by a lack of advanced cell-responsive bioinks that enable bioprinting with high structural fidelity, particularly i... | No full text available |
10. 1002/adhm. 201700015 | 2,024 | Advanced healthcare materials | Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue | Fabricating three-dimensional (3D) large-scale bone tissue constructs with functional vasculature has been a particular challenge in tissue engineering to repair large bone defects. To address this challenge, a direct-writing bioprinting strategy is utilized to fabricate microstructured bone-like tissue constructs cont... | No full text available |
10. 1002/adhm. 201700311 | 2,020 | Advanced healthcare materials | Melt Electrospinning Writing of Poly-Hydroxymethylglycolide- | Current limitations in cardiac tissue engineering revolve around the inability to fully recapitulate the structural organization and mechanical environment of native cardiac tissue. This study aims at developing organized ultrafine fiber scaffolds with improved biocompatibility and architecture in comparison to the tra... | No full text available |
10. 1002/adhm. 201700433 | 2,018 | Advanced healthcare materials | Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications | During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanc... | 1. Introduction The supercritical fluid (SCF) technology is perhaps one of the most renowned high-pressure techniques so far to obtain products with better performances. This technology has been commercially used for many years in the pharmaceutical, textile, and food industries. [ 1 ] The reasons behind the wide adopt... |
10. 1002/adhm. 201700523 | 2,018 | Advanced healthcare materials | Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs | Gradient hydrogels have been developed to mimic the spatiotemporal differences of multiple gradient cues in tissues. Current approaches used to generate such hydrogels are restricted to a single gradient shape and distribution. Here, a hydrogel is designed that includes two chemical cross-linking networks, biofunctiona... | No full text available |
10. 1002/adhm. 201700605 | 2,018 | Advanced healthcare materials | Programmable hydrogels for cell encapsulation and neo-tissue growth to enable personalized tissue engineering | Biomimetic and biodegradable synthetic hydrogels are emerging as a promising platform for cell encapsulation and tissue engineering. Notably, synthetic-based hydrogels offer highly programmable macroscopic properties (e. g. , mechanical, swelling and transport properties) and degradation profiles through control over s... | No full text available |
10. 1002/adhm. 201700681 | 2,018 | Advanced healthcare materials | Fundamentals of Laser-Based Hydrogel Degradation and Applications in Cell and Tissue Engineering | The cell and tissue engineering fields have profited immensely through the implementation of highly-structured biomaterials. The development and implementation of advanced biofabrication techniques has established new avenues for generating biomimetic scaffolds for a multitude of cell and tissue engineering application... | No full text available |
10. 1002/adhm. 201700939 | 2,018 | Advanced Healthcare Materials | Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine | Abstract Regenerative medicine aims to tackle a panoply of challenges from repairing focal damage to articular cartilage to preventing pathological tissue remodeling after myocardial infarction. Hydrogels are water‐swollen networks formed from synthetic or naturally derived polymers and are emerging as important tools ... | 1 Introduction Hydrogels are water‐swollen polymer networks formed by cross‐linked polymer chains and are ubiquitous in nature. The slime‐producing, eel‐like hagfish releases a mucin‐based hydrogel to choke its predators, 1 and humans rely on a hydrogel network composed of collagen and hyaluronic acid (HA) to form the ... |
10. 1002/adhm. 201700988 | 2,017 | Advanced healthcare materials | Hydrogel Encapsulation Facilitates Rapid-Cooling Cryopreservation of Stem Cell-Laden Core-Shell Microcapsules as Cell-Biomaterial Constructs | Core-shell structured stem cell microencapsulation in hydrogel has wide applications in tissue engineering, regenerative medicine, and cell-based therapies because it offers an ideal immunoisolative microenvironment for cell delivery and 3D culture and differentiation. Long-term storage of such microcapsules as cell-bi... | No full text available |
10. 1002/adhm. 201701069 | 2,018 | Advanced healthcare materials | Biodegradable nanoparticles enhanced adhesiveness of mussel-like hydrogels at tissue interface | Popular bioadhesives, such as fibrin, cyanoacrylate and albumin–glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. We developed a musse... | No full text available |
10. 1002/adhm. 201701161 | 2,018 | Advanced healthcare materials | Recent advances in extrusion-based 3D printing for biomedical applications | Additive manufacturing, or 3D printing, has become significantly more commonplace in tissue engineering over the past decade, as a variety of new printing materials have been developed. In extrusion-based printing, materials are used for applications that range from cell free printing to cell-laden bioinks that mimic n... | No full text available |
10. 1002/adhm. 201701213 | 2,018 | Advanced healthcare materials | Advances in Carbon Nanotubes - Hydrogel Hybrids in Nanomedicine for Therapeutics | In-spite of significant advancement in hydrogel technology, low mechanical strength and lack of electrical conductivity has limited their next level biomedical applications for skeletal muscles, cardiac and neural cells. Host-guest chemistry based hybrid nanocomposites systems have gained attention as they completely o... | No full text available |
10. 1002/adhm. 201701347 | 2,019 | Advanced healthcare materials | Patient-specific bioinks for 3D bioprinting of tissue engineering scaffolds | Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various three dimensional (3D) printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance o... | No full text available |
10. 1002/adhm. 201701407 | 2,018 | Advanced healthcare materials | Current Concepts in Meniscus Tissue Engineering and Repair | The meniscus is the most commonly injured structure in the human knee. Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex thr... | No full text available |
10. 1002/adhm. 201800132 | 2,019 | Advanced healthcare materials | Micelle-coated, Hierarchically Structured Nanofibers with Dual-release Capability for Accelerated Wound Healing and Infection Control | Tailoring nanofibrous matrices ‒ a material with much promise for wound healing applications ‒ to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocom... | No full text available |
10. 1002/adhm. 201800160 | 2,018 | Advanced healthcare materials | Assembly of PEG Microgels into Porous Cell-Instructive 3D Scaffolds via Thiol-Ene Click Chemistry | The assembly of microgel building blocks into 3D scaffolds is an emerging strategy for tissue engineering. A key advantage is that the inherent microporosity of these scaffolds provides cells with a more permissive environment than conventional nanoporous hydrogels. Here, norbornene-bearing poly(ethylene glycol) (PEG) ... | No full text available |
10. 1002/adhm. 201800222 | 2,018 | Advanced healthcare materials | Tunable Elastomers with an Antithrombotic Component for Cardiovascular Applications | Here we report the development of a novel family of biodegradable polyurethanes for use as tissue engineered cardiovascular scaffolds or blood-contacting medical devices. Covalent incorporation of the antiplatelet agent dipyridamole into biodegradable polycaprolactone-based polyurethanes yields biocompatible materials ... | No full text available |
10. 1002/adhm. 201800750 | 2,019 | Advanced healthcare materials | Micropatterned Scaffolds with Immobilized Growth Factor Genes Regenerate Bone and Periodontal Ligament-Like Tissues | Periodontal disease destroys supporting structures of teeth; however, tissue engineering strategies offer potential to enhance regeneration. Here, we combined the strategies of patterned topography, spatiotemporally-controlled growth factor gene delivery, and cell-based therapy to repair bone-periodontal ligament (PDL)... | No full text available |
10. 1002/adhm. 201800845 | 2,019 | Advanced healthcare materials | Facile Engineering of Long-Term Culturable Ex Vivo Vascularized Tissues Using Biologically Derived Matrices | Recent advances in tissue engineering and 3D bioprinting have enabled construction of cell-laden scaffolds containing perfusable vascular networks. Although these methods partially address the nutrient-diffusion limitations present in engineered tissues, they are still restricted in both their viable vascular geometrie... | No full text available |
10. 1002/adhm. 201800992 | 2,020 | Advanced healthcare materials | A Photo-crosslinkable Kidney ECM-derived Bioink Accelerates Renal Tissue Formation | 3D bioprinting strategies in tissue engineering aim to fabricate clinically applicable tissue constructs that can replace the damaged or diseased tissues and organs. One of the main prerequisites in 3D bioprinting is finding an appropriate bioink that provides a tissue-specific microenvironment supporting the cellular ... | No full text available |
10. 1002/adhm. 201801011 | 2,019 | Advanced healthcare materials | A New Era of Cardiac Cell Therapy: Opportunities and Challenges | Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a numbe... | No full text available |
10. 1002/adhm. 201801168 | 2,019 | Advanced healthcare materials | Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration | Although skeletal muscle is highly regenerative following injury or disease, endogenous self-regeneration is severely impaired in conditions of volume traumatic muscle loss. Consequently, tissue engineering approach is a promising approach to regenerate skeletal muscle. Biological scaffolds serve as not only structural... | No full text available |
10. 1002/adhm. 201801236 | 2,020 | Advanced healthcare materials | Tissue engineering for the temporomandibular joint | Tissue engineering potentially offers new treatments for disorders of the temporomandibular joint which frequently afflict patients. Damage or disease in this area adversely affects masticatory function and speaking, reducing patients’ quality of life. Effective treatment options for patients suffering from severe temp... | No full text available |
10. 1002/adhm. 201801471 | 2,023 | Advanced healthcare materials | Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application | The skin is responsible for several important physiological functions and has enormous clinical significance in wound healing. Tissue engineered substitutes may be used in patients suffering from skin injuries to support regeneration of the epidermis, dermis, or both. Skin substitutes are also gaining traction in the c... | No full text available |
10. 1002/adhm. 201900506 | 2,019 | Advanced healthcare materials | Soft-Nanoparticle Functionalized Natural Hydrogels for Tissue Engineering Applications | Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an imp... | No full text available |
10. 1002/adhm. 201900626 | 2,019 | Advanced healthcare materials | Vascularized and Innervated Skeletal Muscle Tissue Engineering | Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising... | No full text available |
10. 1002/adhm. 201900775 | 2,020 | Advanced healthcare materials | Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step | Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart... | 1 The Failing Heart Heart failure (HF) is a leading cause of morbidity and mortality for both men and women worldwide. With an estimated worldwide prevalence of 26 million patients and a severe prognosis of 50% mortality within five years, heart failure imposes an enormous burden on society. [ 1 ] Despite major advance... |
10. 1002/adhm. 201900979 | 2,020 | Advanced healthcare materials | A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues | For creating functional tissue analogues in tissue engineering, stem cells require very specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are used nowadays can find such an environment in a heterogeneous protein mixture with the trade name Matrigel. Several variations of synthetic hyd... | 1 Introduction Shortcomings of autologous tissue transplants and the shortage of donor organs are a major clinical burden to society. Tissue engineering and regenerative medicine are considered as a potential solution to overcome this problem. Considerable advancements over the course of almost 30 years resulted in the... |
10. 1002/adhm. 201901036 | 2,019 | Advanced Healthcare Materials | Mechanical Response of Neural Cells to Physiologically Relevant Stiffness Gradients | Abstract Understanding the influence of the mechanical environment on neurite behavior is crucial in the development of peripheral nerve repair solutions, and could help tissue engineers to direct and guide regeneration. In this study, a new protocol to fabricate physiologically relevant hydrogel substrates with contro... | 1 Introduction Large gap peripheral nerve injuries are highly debilitating, causing paralysis and loss of sensation. The current clinical solution, the nerve graft, is often unsatisfactory 1 in terms of functional recovery and has various limitations such as donor site morbidity and limited availability. 2 Improved per... |
10. 1002/adhm. 201901396 | 2,020 | Advanced healthcare materials | Specialty Tough Hydrogels and their Biomedical Applications | Hydrogels have long been explored as attractive materials for biomedical applications given their outstanding biocompatibility, high water content, and versatile fabrication platforms into materials with different physiochemical properties and geometries. Nonetheless, conventional hydrogels suffer from weak mechanical ... | No full text available |
10. 1002/adhm. 201901556 | 2,020 | Advanced healthcare materials | Thermoresponsive inverted colloidal crystal hydrogel scaffolds for lymphoid tissue engineering | Inverted colloidal crystal (ICC) hydrogel scaffolds represent unique opportunities in modeling lymphoid tissues and expanding hematopoietic-lymphoid cells. Fully interconnected spherical pore arrays direct the formation of stromal networks and facilitate interactions between stroma and hematopoietic-lymphoid cells. How... | No full text available |
10. 1002/adhm. 201901580 | 2,020 | Advanced healthcare materials | Conditioning of 3D Printed Nanoengineered Ionic-Covalent Entanglement Scaffolds with iP-hMSCs Derived Matrix | Additive manufacturing is a promising method for producing customized three-dimensional (3D) bioactive constructs for regenerative medicine. Here, we report 3D printed highly osteogenic scaffolds using nanoengineered ionic-covalent entanglement ink (NICE) for bone tissue engineering. This NICE ink consists of ionic-cov... | No full text available |
10. 1002/adhm. 201901714 | 2,020 | Advanced healthcare materials | Stimuli-Responsive Delivery of Growth Factors for Tissue Engineering | Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half-life within the physiological microenvironment and significant side effects caused by of... | No full text available |
10. 1002/adhm. 202000030 | 2,020 | Advanced healthcare materials | ‘Looping in’ Mechanics: Mechanobiologic regulation of the Nucleus and the Epigenome | Cells respond to physical cues in their microenvironment. These cues result in changes in cell behavior, some of which are transient, and others of which are permanent. Understanding and leveraging permanent alteration of cell behavior induced by mechanical cues, or ‘mechanical memories’, is an important aim in cell an... | No full text available |
10. 1002/adhm. 202000806 | 2,020 | Advanced Healthcare Materials | Microporous Biodegradable Films Promote Therapeutic Angiogenesis | Abstract Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angioge... | 1 Introduction Peripheral arterial disease (PAD) is often caused by the build‐up of atherosclerotic fat in the arteries, which, if left untreated, can develop into limb ischemia and other forms of cardiovascular disease. [ 1 ] PAD is becoming more prevalent with over 200 million people affected worldwide as a result of... |
10. 1002/adhm. 202001028 | 2,020 | Advanced healthcare materials | Microfluidic Biomaterials | Since their initial description in 2005, biomaterials that are patterned to contain microfluidic networks (“microfluidic biomaterials”) have emerged as promising scaffolds for a variety of tissue engineering and related applications. This class of materials is characterized by the ability to be readily perfused. Transp... | No full text available |
10. 1002/adhm. 202001305 | 2,021 | Advanced healthcare materials | Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing and Regeneration | Tendon and ligament injuries caused by trauma and degenerative diseases are frequent and affect diverse groups of the population. Such injuries reduce musculoskeletal performance, limit joint mobility, and lower people’s comfort. Currently, various treatment strategies and surgical procedures are used to heal, repair, ... | No full text available |
10. 1002/adhm. 202001600 | 2,021 | Advanced healthcare materials | Three Dimensional Bioprinting of Neural Tissues | The human nervous system is a remarkably complex physiological network that is inherently challenging to study because of obstacles to acquiring primary samples. Animal models offer powerful alternatives to study nervous system development, diseases, and regenerative processes, however, they are unable to address some ... | No full text available |
10. 1002/adhm. 202001657 | 2,020 | Advanced healthcare materials | Hybrid Bioprinting of Zonally-stratified Human Articular Cartilage Using Scaffold-free Tissue Strands as Building Blocks | The heterogeneous and anisotropic articular cartilage is generally studied as a layered structure of ‘zones’ with unique composition and architecture, which is difficult to recapitulate using current approaches. We here present a novel hybrid bioprinting strategy to generate zonally-stratified cartilage. Scaffold-free ... | No full text available |
10. 1002/adhm. 202001941 | 2,022 | Advanced healthcare materials | Oxidation-responsive, tunable growth factor delivery from polyelectrolyte-coated implants | Polyelectrolyte multilayer (PEM) coatings, constructed on the surfaces of tissue engineering scaffolds using layer-by-layer assembly (LbL), promote sustained release of therapeutic molecules and have enabled regeneration of large-scale, pre-clinical bone defects. However, these systems primarily rely on non-specific hy... | No full text available |
10. 1002/adhm. 202001986 | 2,021 | Advanced healthcare materials | Multi-dimensional Printing for Bone Tissue Engineering | The development of three-dimensional (3D) printing has significantly advanced the field of bone tissue engineering by enabling the fabrication of scaffolds that faithfully recapitulate desired mechanical properties and architectures. In addition, computer-based manufacturing relying on patient-derived medical images pe... | No full text available |
10. 1002/adhm. 202002030 | 2,022 | Advanced healthcare materials | Mechanobiological interactions between dynamic compressive loading and viscoelasticity on chondrocytes in hydrazone covalent adaptable networks for cartilage tissue engineering | Mechanobiological cues influence chondrocyte biosynthesis and are often used in tissue engineering applications to improve the repair of articular cartilage in load-bearing joints. In this work, we explore the biophysical effects of an applied dynamic compression on chondrocytes encapsulated in viscoelastic hydrazone c... | No full text available |
10. 1002/adhm. 202002152 | 2,021 | Advanced healthcare materials | null | Extremity skeletal muscle injuries result in substantial disability. Current treatments fail to recoup muscle function, and properly designed and implemented tissue engineering and regenerative medicine techniques can overcome this challenge. In this study, we present a nanoengineered, growth factor eluting bioink that... | No full text available |
10. 1002/adhm. 202002214 | 2,021 | Advanced healthcare materials | Engineered Cytokines for Cancer and Autoimmune Disease Immunotherapy | Cytokine signaling is critical to a range of biological processes including cell development, tissue repair, aging, and immunity. In addition to acting as key signal mediators of the immune system, cytokines can also serve as potent immunotherapies with more than 20 recombinant products currently FDA-approved to treat ... | No full text available |
10. 1002/adhm. 202100625 | 2,021 | Advanced healthcare materials | Tunable three-dimensional hydrogel microchannel networks to study confined mammalian cell migration | Cells adapt and move due to chemical, physical and mechanical cues from their microenvironment. It is therefore important to create materials that mimic human tissue physiology by surface chemistry, architecture, and dimensionality to control cells in biomedical settings. The impact of the environmental architecture is... | No full text available |
10. 1002/adhm. 202100644 | 2,021 | Advanced healthcare materials | 3D printing of microgel scaffolds with tunable void fraction to promote cell infiltration | Granular, microgel-based materials have garnered interest as promising tissue engineering scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these materials for 3D bioprinting, while maintaining sufficient void space to enable cell migration, can be challenging, since the rheologica... | No full text available |
10. 1002/adhm. 202101329 | 2,021 | Advanced healthcare materials | Extracellular matrix-mimetic hydrogels for treating neural tissue injury: a focus on fibrin, hyaluronic acid, and elastin-like polypeptide hydrogels | Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide three-dimensional bioactive interfa... | No full text available |
10. 1002/adhm. 202101867 | 2,021 | Advanced healthcare materials | Nucleic Acid Delivery from Granular Hydrogels | Nucleic acid delivery has applications ranging from tissue engineering to vaccine development to infectious disease. Cationic polymer condensed nucleic acids have been used with surface coated porous scaffolds and are able to promote long term gene expression. However, due to surface loading of the scaffold, there is a... | No full text available |
10. 1002/adhm. 202102351 | 2,022 | Advanced healthcare materials | Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks | Recapitulation of the microstructural organization of cellular and extracellular components found in natural tissues is an important but challenging feat for tissue engineering, which demands innovation across both process and material fronts. In this work, we demonstrate a highly versatile ultrasound-assisted biofabri... | No full text available |
10. 1002/adhm. 202102697 | 2,024 | Advanced healthcare materials | Enzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials | Oxygen releasing biomaterials can facilitate the survival of living implants by creating environments with a viable oxygen level. Hydrophobic oxygen generating microparticles (HOGMPs) encapsulated calcium peroxide (CPO) have recently been used in tissue engineering to release physiologically relevant amounts of oxygen ... | No full text available |
10. 1002/adhm. 202102795 | 2,022 | Advanced healthcare materials | Combinatorial Use of Therapeutic ELP-Based Micelle Particles in Tissue Engineering | Elastin-like peptides (ELPs) are a versatile platform for tissue engineering and drug delivery. In this study, micelle forming ELP chains are genetically fused to three therapeutic molecules, keratinocyte growth factor (KGF), stromal cell-derived growth factor 1 (SDF1), and cathelicidin (LL37), to be used in wound heal... | No full text available |
10. 1002/adhm. 202200027 | 2,022 | Advanced healthcare materials | Tunable Microgel-Templated Porogel (MTP) Bioink for 3D Bioprinting Applications | Micropores are essential for tissue engineering to ensure adequate mass transportation for embedded cells. Despite the considerable progress made by advanced 3D bioprinting technologies, it remains challenging to engineer micropores of 100 μm or smaller in cell-laden constructs. Here, a microgel-templated porogel (MTP)... | 1 Introduction Micropores are significantly crucial for tissue engineering scaffolds and many other 3D cell culture systems as they generate a large surface area for cell attachment and mediate mass transportation for cell growth. [ 1 – 3 ] In the past three decades, tissue engineering has seen considerable progress wi... |
10. 1002/adhm. 202200055 | 2,022 | Advanced healthcare materials | Recent advances in designing electroconductive biomaterials for cardiac tissue engineering | Implantable cardiac patches and injectable hydrogels are among the most promising therapies for cardiac tissue regeneration following myocardial infarction (MI). Incorporating electrical conductivity into these patches and hydrogels has been found to be an efficient method to improve cardiac tissue function. Conductive... | No full text available |
10. 1002/adhm. 202200293 | 2,022 | Advanced healthcare materials | Cytoprotection of human progenitor and stem cells through encapsulation in alginate templated, dual crosslinked silk and silk - gelatin composite hydrogel microbeads | Susceptibility of mammalian cells against harsh processing conditions limit their use in cell transplantation and tissue engineering applications. Besides modulation of the cell microenvironment, encapsulation of mammalian cells within hydrogel microbeads attract attention for cytoprotection through physical isolation ... | No full text available |
10. 1002/adhm. 202200471 | 2,022 | Advanced healthcare materials | Growing pains: the need for engineered platforms to study growth plate biology | Growth plates, or physis, are highly specialized cartilage tissues responsible for longitudinal bone growth in children and adolescents. Chondrocytes that reside in growth plates are organized into three distinct zones essential for proper function. Modeling key features of growth plates may provide an avenue to develo... | No full text available |
10. 1002/adhm. 202200481 | 2,022 | Advanced healthcare materials | Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning | The ultimate objective of tissue engineering is to fabricate artificial living constructs with a structural organization and function that faithfully resembles their native tissue counterparts. For example, the deep zone of articular cartilage possesses a distinctive anisotropic architecture with chondrocytes organized... | 1 Introduction The coordinated functions of natural tissues are enabled by the presence of conserved structural features, from the arrangement of cells to the organization of extracellular matrix components. Replicating these structural aspects is critical when seeking to engineer functional tissue grafts or relevant b... |
10. 1002/adhm. 202201138 | 2,022 | Advanced Healthcare Materials | Large‐Scale Production of Wholly Cellular Bioinks via the Optimization of Human Induced Pluripotent Stem Cell Aggregate Culture in Automated Bioreactors | Abstract Combining the sustainable culture of billions of human cells and the bioprinting of wholly cellular bioinks offers a pathway toward organ‐scale tissue engineering. Traditional 2D culture methods are not inherently scalable due to cost, space, and handling constraints. Here, the suspension culture of human indu... | 1 Introduction The promise of biomanufactured autologous tissues and organs on demand has been a long‐standing challenge in the field of tissue engineering. The absence of readily perfusable vascular networks had limited the scale at which traditional scaffold‐based approaches could generate viable solid organ tissues.... |
10. 1002/adhm. 202201378 | 2,022 | Advanced healthcare materials | Tailored Biocompatible Polyurethane-Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial | Polyurethane-based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompati... | 1 Introduction Hydrogels are popular materials in biomedical engineering with myriad applications in drug delivery, [ 1 ] prosthetics and implants, [ 2 ] tissue engineering, [ 3 – 5 ] and soft robotics. [ 6 ] The similarity in water content between hydrogels and soft tissues, as well as the tunability of their mechanic... |
10. 1002/adhm. 202202591 | 2,023 | Advanced healthcare materials | Linguistic analysis identifies emergent biomaterial fabrication trends for orthopaedic applications | The expanse of publications in tissue engineering and orthopaedics over the past 20 years presents an opportunity to probe emergent trends in the field to better guide future technologies that can make an impact on musculoskeletal therapies. Leveraging this trove of knowledge, we developed a hierarchical systematic sea... | No full text available |
10. 1002/adma. 201303233 | 2,014 | Advanced materials (Deerfield Beach, Fla. ) | 25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine | Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineer... | No full text available |
10. 1002/adma. 201500329 | 2,015 | Advanced materials (Deerfield Beach, Fla. ) | Generation of Electrospun Nanofibers with Controllable Degrees of Crimping through a Simple, Plasticizer-based Treatment | A method was developed for generating crimped features in uniaxially aligned electrospun nanofibers to mimic the anatomic structure of collagen fibrils in tendon tissues. We demonstrated that nanofibers comprised of poly(lactic acid) (PLA) and its copolymers or blends would shrink to generate crimped features along the... | No full text available |
10. 1002/adma. 201500417 | 2,015 | Advanced materials (Deerfield Beach, Fla. ) | Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control | The growth of tissues and organs is regulated by orchestrated signals from biomolecules such as enzymes and growth factors. The ability to deliver signal molecules in response to particular biological events (e. g. , enzyme expression and activation) holds great promise towards tissue healing and regeneration. The curr... | No full text available |
10. 1002/adma. 201501558 | 2,015 | Advanced materials (Deerfield Beach, Fla. ) | Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering | Adaptable hydrogels have recently emerged as a promising platform for three-dimensional (3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels, degradation is typically required to allow complex cellular functions to occur, leading to bulk material degradation. In contrast, adaptable hyd... | No full text available |
10. 1002/adma. 201503844 | 2,015 | Advanced Materials (Deerfield Beach, Fla. ) | Cucurbituril‐Regulated Nanopatterning of Binary Polymer Brushes via Colloidal Templating | Sub‐micrometer/nanoscale patterned polymer brushes are prepared by employing cucurbituril (CB) as a supramolecular recognition motif to assemble functional silica colloids onto Au surfaces as a sacrificial nanopatterning template. By employing CB‐mediated host–guest interactions at the interface, it is possible to read... | Interest in the fabrication of micro‐/nanopatterned polymer surfaces with high precision has grown substantially in recent years, on account of potential applications in surface‐based technologies including photovoltaic devices, 1 semiconductors, 2, 3 photonic crystals, 4 nanofluidic devices, 5 and platforms for tissue... |
10. 1002/adma. 201600240 | 2,016 | Advanced materials (Deerfield Beach, Fla. ) | Anisotropic materials for skeletal muscle tissue engineering | Repair of damaged skeletal muscle tissue is limited by the regenerative capacity of native tissue. Current clinical approaches are not optimal for treatment of large volumetric skeletal muscle loss. As an alternative, tissue engineering represents a promising approach for the functional restoration of damaged muscle ti... | No full text available |
10. 1002/adma. 201602947 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Surface acoustic waves grant superior spatial control of cells embedded in hydrogel fibers | Graphical Abstract By exploiting surface acoustic waves (SAWs) and a coupling layer technique, cells are patterned within a photosensitive hydrogel fiber to mimic physiological cell arrangement in tissues. The aligned cell-polymer matrix is polymerized with short exposure to UV light and the fiber is extracted. Embedde... | No full text available |
10. 1002/adma. 201605750 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Biomimetic anisotropic reinforcement architectures by electrically assisted nanocomposite 3D printing | Many natural structures out-perform the conventional synthetic counterparts due to the specially evolved reinforcement architectures. Here we report an electrically assisted additive manufacturing approach that bio-mimic the Bouligand structure in natural creatures to create highly impact resistant architectures. The a... | No full text available |
10. 1002/adma. 201701115 | 2,017 | Advanced materials (Deerfield Beach, Fla. ) | Inverse Opal Scaffolds and Their Biomedical Applications | Three-dimensional porous scaffolds play a pivotal role in tissue engineering and regenerative medicine by functioning as biomimetic substrates to manipulate cellular behaviors. While many techniques have been developed to fabricate porous scaffolds, most of them rely on stochastic processes that typically result in sca... | No full text available |
10. 1002/adma. 201704878 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Photocrosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Micro-gels of Intrinsically Disordered Polypeptides | Hydrogel particles are versatile materials that provide exquisite, tunable control over the sequestration and delivery of materials in pharmaceutics, tissue engineering, and photonics. The favorable properties of hydrogel particles depend largely on their size, and particles ranging from nanometers to micrometers are u... | No full text available |
10. 1002/adma. 201706616 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy | Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell-derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, and to show reduced immunoge... | Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers for various dispositions, such as cancer, inflammation, or tissue injury, and biomarkers for sensing different pathophysiological conditions. [ 1 ] These naturally relea... |
10. 1002/adma. 201800242 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Microfluidics-Enabled Multi-Material Maskless Stereolithographic Bioprinting | This communication presents a stereolithography-based bioprinting platform for multi-material fabrication of heterogeneous hydrogel constructs. Dynamic patterning by a digital micro-mirror device (DMD), synchronized by a moving stage and a microfluidic device containing four on/off pneumatic valves, is used to create 3... | No full text available |
10. 1002/adma. 201802649 | 2,018 | Advanced Materials (Deerfield Beach, Fla. ) | Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning | Abstract Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that ultrasound standing waves can be used to organize myoblast populations in... | The majority of bioengineering strategies use materials with isotropic cell distribution to produce homogenous tissue structures. These engineered tissues, however, generally lack the microscale cellular organization necessary for coordinated mechanical function, biological maturation, and in vivo integration. 1 Biopri... |
10. 1002/adma. 201802732 | 2,018 | Advanced materials (Deerfield Beach, Fla. ) | Protein-Corona-by-Design in 2D: A Reliable Platform to Decode Bio–Nano Interactions for the Next-Generation Quality-by-Design Nanomedicines | Hard corona (HC) protein, i. e. , the environmental proteins of the biological medium that are bound to a nanosurface, is known to affect the biological fate of a nanomedicine. Due to the size, curvature, and specific surface area (SSA) 3-factor interactions inherited in the traditional 3D nanoparticle, HC-dependent bi... | Hard corona (HC) protein, i. e. , proteins that are strongly associated with the surface of nanomaterials in biological environments, has drawn much attention in the field of nanomedicine. [ 1 – 3 ] HC profiles critically affect the nanomedicine stealth effect, [ 3 ] cellular uptake, [ 4 ] nanoparticle pathophysiology,... |
10. 1002/adma. 201805460 | 2,019 | Advanced materials (Deerfield Beach, Fla. ) | Aqueous Two-Phase Emulsion Bioink-Enabled 3D Bioprinting of Porous Hydrogels | The three-dimensional (3D) bioprinting technology provides programmable and customizable platforms to engineer cell-laden constructs mimicing human tissues for a wide range of biomedical applications. However, the encapsulated cells are often restricted in spreading and proliferation by dense biomaterial networks from ... | No full text available |
10. 1002/adma. 201900291 | 2,019 | Advanced materials (Deerfield Beach, Fla. ) | Buoyancy-driven Gradients for Biomaterial Fabrication and Tissue Engineering | The controlled fabrication of gradient materials is becoming increasingly important as the next generation of tissue engineering seeks to produce inhomogeneous constructs with physiological complexity. Current strategies for fabricating gradient materials can require highly specialized materials or equipment, and canno... | No full text available |
10. 1002/adma. 201902462 | 2,021 | Advanced materials (Deerfield Beach, Fla. ) | Logic-Based Delivery of Site-Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials | The controlled presentation of proteins from and within materials remains of significant interest for many bioengineering applications. Though “smart” platforms offer control over protein release in response to a single external cue, no strategy has been developed to trigger delivery in response to user-specified combi... | No full text available |
10. 1002/adma. 201904598 | 2,019 | Advanced materials (Deerfield Beach, Fla. ) | Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues | The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3D collagen hydroge... | Directing cellular organization within 3D hydrogel matrices in a controlled manner is of great importance in the field of regenerative medicine and remains a major challenge. A multitude of technologies have been described to control the spatial organization of cells in 3D engineered heart constructs including mechanic... |
10. 1002/adma. 201905914 | 2,020 | Advanced materials (Deerfield Beach, Fla. ) | Ultrasound-Triggered Enzymatic Gelation | Hydrogels are formed using various triggers, including light irradiation, pH adjustment, heating, cooling, or chemical addition. Here, a new method for forming hydrogels is introduced: ultrasound-triggered enzymatic gelation. Specifically, ultrasound is used as a stimulus to liberate liposomal calcium ions, which then ... | Hydrogels are hydrated, 3D polymeric networks that are widely used for applications in tissue engineering, drug delivery, soft robotics, and bioelectronics. [ 1 – 6 ] The base materials encompass a broad range of hydrophilic homopolymers, copolymers, or macromers, which can be natural (e. g. , collagen, alginate, fibri... |
10. 1002/adma. 201906423 | 2,020 | Advanced materials (Deerfield Beach, Fla. ) | From Shape to Function: The Next Step in Bioprinting | In 2013, the “biofabrication window” was introduced to reflect the processing challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable materials that could serve as cell-laden bioinks, as well as the limitations of printing and assembly methods, presented a major constraint. Howev... | 1 Introduction The functionality of living tissues is intimately linked to their intricate and highly specialized architecture. Tissues and organs are composed of multiple types of cells and extracellular matrix (ECM) components and, with few exceptions, are infiltrated with vascular and neural networks. The hierarchic... |
10. 1002/adma. 202001668 | 2,020 | Advanced Materials (Deerfield Beach, Fla. ) | Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions | Abstract Engineered nano–bio cellular interfaces driven by 1D vertical nanostructures (1D‐VNS) are set to prompt radical progress in modulating cellular processes at the nanoscale. Here, tuneable cell–VNS interfacial interactions are probed and assessed, highlighting the use of 1D‐VNS in immunomodulation, and intracell... | 1 Introduction Advances in bionanotechnology have fostered significant improvements in biomedical engineering and preclinical studies. [ 1 ] Impressive progress in the nascent field of programmable nano–bio interfaces—especially in the design of nanotopographies optimized to facilitate biomolecular delivery, genome edi... |
10. 1002/adma. 202003310 | 2,020 | Advanced materials (Deerfield Beach, Fla. ) | Controlled lengthwise assembly of helical peptide nanofibers to modulate CD8 | Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fiber lengths and an incomplete understanding of how nanofiber len... | No full text available |
10. 1002/adma. 202003754 | 2,020 | Advanced materials (Deerfield Beach, Fla. ) | Converting 2D Nanofiber Membranes to 3D Hierarchical Assemblies with Structural and Compositional Gradients Regulates Cell Behavior | New methods are described for converting two-dimensional (2D) electrospun nanofiber membranes to three-dimensional (3D) hierarchical assemblies with structural and compositional gradients. Pore size gradients are generated by tuning the expansion of 2D membranes in different layers with incorporation of various amounts... | No full text available |
10. 1002/adma. 202005346 | 2,021 | Advanced materials (Deerfield Beach, Fla. ) | High definition single cell printing: Cell-by-cell fabrication of biological structures | Bioprinting is a powerful technology with the potential to transform medical device manufacturing, organ replacement, and the treatment of diseases and physiologic malformations. However, current bioprinters are unable to reliably print the fundamental unit of all living things, single cells. Here, we present high defi... | No full text available |
10. 1002/adma. 202100176 | 2,021 | Advanced materials (Deerfield Beach, Fla. ) | Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing | With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration of chronic wounds is an important challenge. Since immune reaction to the tissue damage is critical in regulating both the quality and duration of chronic wound healing cascade, strategies to modulate the... | No full text available |
10. 1002/adma. 202104730 | 2,021 | Advanced materials (Deerfield Beach, Fla. ) | Emerging Technologies in Multi-Material Bioprinting | Bioprinting, within the emerging field of biofabrication, aims at the fabrication of functional biomimetic constructs. Different three-dimensional bioprinting techniques have been adapted to bioprint cell-laden bioinks. However, single-material bioprinting techniques oftentimes fail to reproduce the complex composition... | No full text available |
10. 1002/adma. 202105883 | 2,022 | Advanced materials (Deerfield Beach, Fla. ) | Bioinks and bioprinting strategies for skeletal muscle tissue engineering | Skeletal muscles play important roles in critical body functions and their injury or diseases can lead to limitation of mobility and loss of independence. Current treatment modalities result in variable functional recovery, while reconstructive surgery, as the gold standard approach, is limited due to donor shortage, d... | No full text available |
10. 1002/adma. 202109394 | 2,022 | Advanced materials (Deerfield Beach, Fla. ) | Jammed Micro-Flake Hydrogel for 4D Living Cell Bioprinting | Four-dimensional (4D) bioprinting is promising to build cell-laden constructs (bioconstructs) with complex geometries and functions for tissue/organ regeneration applications. The development of hydrogel-based 4D bioinks, especially those allowing living cell printing, with easy preparation, defined composition, and co... | No full text available |
10. 1002/adma. 202110441 | 2,022 | Advanced Materials (Deerfield Beach, Fla. ) | Biobased Elastomer Nanofibers Guide Light‐Controlled Human‐iPSC‐Derived Skeletal Myofibers | Abstract Generating skeletal muscle tissue that mimics the cellular alignment, maturation, and function of native skeletal muscle is an ongoing challenge in disease modeling and regenerative therapies. Skeletal muscle cultures require extracellular guidance and mechanical support to stabilize contractile myofibers. Exi... | 1 Introduction Advances in the field of skeletal muscle tissue engineering depend on generating stable and life‐like skeletal muscle microtissues in vitro. This requires an interdisciplinary approach, whereby cells are incorporated into a biological or synthetic mechanical microenvironment. Such work enables accurate m... |
10. 1002/adma. 202206933 | 2,023 | Advanced materials (Deerfield Beach, Fla. ) | Self-Powered Programming of Fibroblasts into Neurons via a Scalable Magnetoelastic Generator Array | Developing scalable electrical stimulating platforms for cell and tissue engineering applications is limited by external power source dependency, wetting resistance, microscale size requirements, and suitable flexibility. Here, a versatile and scalable platform is developed to enable tunable electrical stimulation for ... | No full text available |
10. 1002/adma. 202207255 | 2,023 | Advanced materials (Deerfield Beach, Fla. ) | Engineered Living Intestinal Muscle Patch Produces Macroscopic Contractions that can Mix and Break down Artificial Intestinal Contents | The intestinal muscle layers execute various gut wall movements to achieve controlled propulsion and mixing of intestinal content. Engineering intestinal muscle layers with complex contractile function is critical for developing bioartificial intestinal tissue to treat patients with short bowel syndrome. Here we report... | No full text available |
10. 1002/adma. 202207335 | 2,023 | Advanced materials (Deerfield Beach, Fla. ) | Extracellular Matrix Secretion Mechanically Reinforces Interlocking Interfaces | Drawing inspiration for biomaterials from biological systems has led to many biomedical innovations. One notable bioinspired device, Velcro, consists of two substrates with interlocking ability. Generating reversibly interlocking biomaterials is an area of investigation, as such devices could allow for modular tissue e... | No full text available |
10. 1002/adma. 202207882 | 2,023 | Advanced materials (Deerfield Beach, Fla. ) | Tunable Mesoscopic Collagen Island Architectures Modulate Stem Cell Behavior | The ECM is the physical scaffold by which mammalian cells interact with their surrounding environment, of which the main constituent is collagen. In real tissue, collagen topology is diverse with complex mesoscopic features. While studies have explored the role of density and stiffness in collagen, the role of architec... | No full text available |
10. 1002/adma. 202209904 | 2,023 | Advanced materials (Deerfield Beach, Fla. ) | User-controlled 4D biomaterial degradation with substrate-selective sortase transpeptidases for single-cell biology | Stimuli-responsive biomaterials show great promise for modelling disease dynamics ex vivo with spatiotemporal control over the cellular microenvironment. However, harvesting cells from such materials for downstream analysis without perturbing their state remains an outstanding challenge in 3D/4D culture and tissue engi... | No full text available |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.