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10. 1002/advs. 201903129 | 2,020 | Advanced Science | Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise | Abstract Developing efficient, sustainable, and biocompatible high‐tech nanoplatforms derived from naturally existing components in living organisms is highly beneficial for diverse advanced biomedical applications. Melanins are nontoxic natural biopolymers owning widespread distribution in various biosystems, possessi... | 1 Introduction Rapid advances in nanotechnology and biomedicine offer great opportunities in the field of nanomedicine. Nature is an immense treasury for scientists, which provides inexhaustible sources of inspiration to design and construct multifunctional biomaterials and devices with extraordinary properties. Develo... |
10. 1002/advs. 201903359 | 2,020 | Advanced Science | Cell‐Inspired All‐Aqueous Microfluidics: From Intracellular Liquid–Liquid Phase Separation toward Advanced Biomaterials | Abstract Living cells have evolved over billions of years to develop structural and functional complexity with numerous intracellular compartments that are formed due to liquid–liquid phase separation (LLPS). Discovery of the amazing and vital roles of cells in life has sparked tremendous efforts to investigate and rep... | 1 Introduction Nature has evolved for billions of years to develop elaborate and sophisticated living organisms, 1, 2, 3, 4, 5, 6, 7, 8, 9 which can provide sources of inspired solutions for various intriguing and enduring scientific and technique questions. 10, 11, 12, 13 Although a single cell is the simplest unit of... |
10. 1002/advs. 201903395 | 2,020 | Advanced Science | Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment | Abstract The treatment of bone defects with recombinant bone morphogenetic protein‐2 (BMP‐2) requires high doses precluding broad clinical application. Here, a bioengineering approach is presented that strongly improves low‐dose BMP‐2‐based bone regeneration by mobilizing healing‐associated mesenchymal progenitor cells... | 1 Introduction Bone defects resulting from trauma or disease are currently treated by transplantation of autologous bone. 1 However, due to limited supply and transplantation‐associated donor site morbidity, great efforts were put into development of off‐the‐shelf materials including recombinant osteogenic factors such... |
10. 1002/advs. 201903516 | 2,020 | Advanced Science | Targeted Repair of Vascular Injury by Adipose‐Derived Stem Cells Modified with P‐Selectin Binding Peptide | Abstract Percutaneous coronary intervention for coronary artery disease treatment often results in pathological vascular injury, characterized by P‐selectin overexpression. Adipose‐derived stem cells (ADSCs) therapeutic efficacy remains elusive due to poor ADSCs targeting and retention in injured vessels. Here, conjuga... | 1 Introduction Cardiovascular diseases, including coronary artery occlusions, are the leading cause of mortality worldwide. [ 1 ] The predominant surgical intervention for occluded coronary and peripheral arteries is percutaneous coronary intervention (PCI), which comprises balloon angioplasty and endoluminal stenting ... |
10. 1002/advs. 201903553 | 2,020 | Advanced Science | A Biomimetic 3D‐Self‐Forming Approach for Microvascular Scaffolds | Abstract The development of science and technology often drew lessons from natural phenomena. Herein, inspired by drying‐driven curling of apple peels, hydrogel‐based micro‐scaled hollow tubules (MHTs) are proposed for biomimicking microvessels, which promote microcirculation and improve the survival of random skin fla... | Recently, some materials became attractive for their self‐forming properties. Self‐forming properties of 2D materials can transform into complex 3D constructions, responding to their varying internal strains. For example, López‐Valdeolivas et al. reported secondary molding of liquid crystalline elastomer to form a 3D s... |
10. 1002/advs. 201903718 | 2,020 | Advanced Science | Designer Self‐Assembling Peptide Hydrogels to Engineer 3D Cell Microenvironments for Cell Constructs Formation and Precise Oncology Remodeling in Ovarian Cancer | Abstract Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and physiochemical properties to serve as biomimetic extracellular matrix (ECM) for biomedical applications. The advantages and benefits are ... | 1 Introduction Ex vivo culture of tumor cells from patients has a low culture success rate and a limited proliferative capacity. The most promising strategy expected to improve the success rates is the utility of current nanomedicine involved in the novel biomaterials and advanced hydrogel technologies. Since healthy m... |
10. 1002/advs. 201903739 | 2,020 | Advanced Science | A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering | Abstract Organoids derived from self‐organizing stem cells represent a major technological breakthrough with the potential to revolutionize biomedical research. However, building high‐fidelity organoids in a reproducible and high‐throughput manner remains challenging. Here, a droplet microfluidic system is developed fo... | There has been a growing interest in building functional 3D organ models in vitro. Organoids are multicellular tissues formed by self‐organization of stem cells in 3D culture, which can mimic corresponding in vivo organ. They represent a major technological breakthrough in creating a new class of organ models. [ 1, 2, ... |
10. 1002/advs. 201903783 | 2,020 | Advanced Science | Advanced Near‐Infrared Light for Monitoring and Modulating the Spatiotemporal Dynamics of Cell Functions in Living Systems | Abstract Light‐based technique, including optical imaging and photoregulation, has become one of the most important tools for both fundamental research and clinical practice, such as cell signal sensing, cancer diagnosis, tissue engineering, drug delivery, visual regulation, neuromodulation, and disease treatment. In p... | 1 Near‐Infrared Light and Its Biomedical Applications Light is an essential physical element that governs a wide range of essential physiological processes in almost all living organisms, including sensing, energy capturing, and metabolism. For instance, animals capture light signals through their eyes to sense the env... |
10. 1002/advs. 201970094 | 2,019 | Advanced Science | Self‐Healable Hydrogels: Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? (Adv. Sci. 16/2019) | The inherent ability of native tissues to regenerate on demand has sparked enormous motivation to develop tissue engineering hydrogels with similar self‐repair mechanisms. However, self‐healable hydrogels still face several shortcomings, which limit their specific application for the replacement of electrically active ... | No full text available |
10. 1002/advs. 202000439 | 2,020 | Advanced Science | Photochemical Activity of Black Phosphorus for Near‐Infrared Light Controlled In Situ Biomineralization | Abstract The photochemical activity of black phosphorus (BP) in near‐infrared (NIR) light controlled in situ biomineralization is investigated. Owing to the excellent NIR absorption, irradiation with NIR light not only promotes degradation of BP into PO 4 3−, but also enhances the chemical activity to accelerate the re... | 1 Introduction As a new and emerging 2D semiconductor containing a single element of phosphorus, black phosphorus (BP) has been shown to have superior physical properties and great potential in a myriad of applications including optoelectronics, catalysis, energy, and biomedicine. [ 1, 2, 3, 4, 5, 6, 7, 8 ] Particularl... |
10. 1002/advs. 202000443 | 2,020 | Advanced Science | Interface Coassembly and Polymerization on Magnetic Colloids: Toward Core–Shell Functional Mesoporous Polymer Microspheres and Their Carbon Derivatives | Abstract Core–shell structured magnetic mesoporous polymer or carbon‐based microspheres not only possess the combined merits of magnetic particles and stable mesoporous shell but also provide various organic functional groups for further modification and immobilization of active sites, thus opening up more possibility ... | Ever since their discovery, ordered mesoporous materials have aroused tremendous research interests owing to their unique properties including tunable mesostructures, high surface area, large pore volume, and various framework components. [ 1, 2, 3 ] Benefiting from these merits, mesoporous materials exhibit potential ... |
10. 1002/advs. 202000494 | 2,020 | Advanced Science | Chemoreactive Nanotherapeutics by Metal Peroxide Based Nanomedicine | Abstract The advances of nanobiotechnology and nanomedicine enable the triggering of in situ chemical reactions in disease microenvironment for achieving disease‐specific nanotherapeutics with both intriguing therapeutic efficacy and mitigated side effects. Metal peroxide based nanoparticles, as one of the important bu... | 1 Introduction The progress of material science has substantially contributed to clinical medicine by the development of versatile high‐performance therapeutic modalities for disease treatment. [ 1, 2, 3, 4, 5 ] This interdisciplinary field promotes the construction of abundant biomaterials with intrinsically unique st... |
10. 1002/advs. 202000735 | 2,020 | Advanced Science | Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers | Abstract Electrospun nanofibers have been extensively explored as a class of scaffolding materials for tissue regeneration, because of their unique capability to mimic some features and functions of the extracellular matrix, including the fibrous morphology and mechanical properties, and to a certain extent the chemica... | 1 Introduction Tissue regeneration can be considered as a medical procedure that integrates the principles of materials science, biology, and engineering to provide a roadmap for recovering the functions of damaged tissues and even organs. [ 1 ] Key to the success of such a treatment is to understand the interactions b... |
10. 1002/advs. 202000769 | 2,020 | Advanced Science | Facile Production of Large‐Area Cell Arrays Using Surface‐Assembled Microdroplets | Abstract Techniques that enable the spatial arrangement of living cells into defined patterns are broadly applicable to tissue engineering, drug screening, and cell–cell investigations. Achieving large‐scale patterning with single‐cell resolution while minimizing cell stress/damage is, however, technically challenging ... | Patterning large‐scale single‐cell arrays enables high‐throughput single‐cell analysis and facilitates in vitro studies of cell–cell communication. [ 1 ] Several strategies have been developed to create arrays of cells on engineered substrata, including programmed stress fields; [ 2, 3, 4, 5 ] microfluidic processing; ... |
10. 1002/advs. 202000843 | 2,020 | Advanced Science | A Rotating Spiral Micromotor for Noninvasive Zygote Transfer | Abstract Embryo transfer (ET) is a decisive step in the in vitro fertilization process. In most cases, the embryo is transferred to the uterus after several days of in vitro culture. Although studies have identified the beneficial effects of ET on proper embryo development in the earlier stages, this strategy is compro... | 1 Introduction Micromotors, untethered devices that move and operate at a microscale, are especially relevant for biomedical applications, potentially enabling localized and controllable material‐to‐cell interactions for therapeutic, [ 1, 2, 3 ] diagnostic, [ 4, 5 ] or microsurgical [ 6, 7 ] purposes in vivo, that is, ... |
10. 1002/advs. 202000863 | 2,020 | Advanced Science | Light‐Responsive Inorganic Biomaterials for Biomedical Applications | Abstract Light‐responsive inorganic biomaterials are an emerging class of materials used for developing noninvasive, noncontact, precise, and controllable medical devices in a wide range of biomedical applications, including photothermal therapy, photodynamic therapy, drug delivery, and regenerative medicine. Herein, a... | 1 Introduction Light has been used in modern medicine as an alternative tool for treating conditions such as skin disorders, melanoma, acne, and depression. [ 1, 2 ] Compared to other forms of energy, such as thermal or magnetic energy, which are widely used as an external impetus to control stimuli‐responsive biomater... |
10. 1002/advs. 202000900 | 2,020 | Advanced Science | A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials | Abstract Angiogenic therapy involving delivery of pro‐angiogenic growth factors to stimulate new blood vessel formation in ischemic disease is promising but has seen limited clinical success due to issues associated with the need to deliver supra‐physiological growth factor concentrations. Bio‐inspired growth factor de... | 1 Introduction Blood vessels allow exchange of oxygen, carbon dioxide, nutrients, and waste at the tissue level and provide conduits for transport of hormones and components of the immune system throughout the body. Inadequate or aberrant vascular supply is a hallmark of many disorders characterized by tissue ischemia,... |
10. 1002/advs. 202000938 | 2,020 | Advanced Science | Atlas of Musculoskeletal Stem Cells with the Soft and Hard Tissue Differentiation Architecture | Abstract Although being of utmost importance for human health and mobility, stem cell identity and hierarchical organization of musculoskeletal progenitors remain largely unexplored. Here, cells from E10. 5, E12. 5, and E15. 5 murine limbs are analyzed by high throughput single‐cell RNA sequencing to illustrate the cel... | 1 Introduction The limb is a complexly patterned, easily observable and experimentally modifiable organ, leading it to be widely used as a model in developmental biology. [ 1 ] Limb development is a complex morphogenetic process that integrates cells from multiple origins into a well‐organized structure. [ 2 ] The corr... |
10. 1002/advs. 202001000 | 2,020 | Advanced Science | Direct Ink Writing Based 4D Printing of Materials and Their Applications | Abstract 4D printing has attracted academic interest in the recent years because it endows static printed structures with dynamic properties with the change of time. The shapes, functionalities, or properties of the 4D printed objects could alter under various stimuli such as heat, light, electric, and magnetic field. ... | 1 Introduction 3D printing or additive manufacturing, which was invented in 1986, is a technique that creates complex and customer‐designed objects without the use of any molds. [ 1, 2, 3 ] This technique has overcome the limitations of traditional processing methods and driven great innovations in various applications... |
10. 1002/advs. 202001264 | 2,020 | Advanced Science | Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides | Abstract Polysaccharides are a class of carbohydrates that play pivotal roles in living systems such as being chemical messengers in many vital biological pathways. However, the complexity and heterogeneity of these natural structures have posed daunting challenges on their production, characterization, evaluation, and... | 1 Introduction Carbohydrates represent a major class of biomolecules existing in nature that have multifaceted functions across the fields from energy source to biological structures. [ 1, 2 ] A prominent feature of carbohydrates is their extremely diverse and complex structures. For instance, several types of carbohyd... |
10. 1002/advs. 202001379 | 2,020 | Advanced Science | Extrusion 3D Printing of Polymeric Materials with Advanced Properties | Abstract 3D printing is a rapidly growing technology that has an enormous potential to impact a wide range of industries such as engineering, art, education, medicine, and aerospace. The flexibility in design provided by this technique offers many opportunities for manufacturing sophisticated 3D devices. The most widel... | 1 Introduction Additive manufacturing (AM), the formal term for 3D printing, was first introduced in the 1980s by Hull. [ 1 ] Since then, fabrication methods have been revolutionized, which has further intensified the influence of polymers on our society. This technology has become the leading rapid prototyping technol... |
10. 1002/advs. 202001419 | 2,020 | Advanced Science | 3D Bioprinting of Macroporous Materials Based on Entangled Hydrogel Microstrands | Abstract Hydrogels are excellent mimetics of mammalian extracellular matrices and have found widespread use in tissue engineering. Nanoporosity of monolithic bulk hydrogels, however, limits mass transport of key biomolecules. Microgels used in 3D bioprinting achieve both custom shape and vastly improved permissivity to... | 1 Introduction Microextrusion 3D bioprinting has recently been used to create functional analogues of many tissues including myocardium, skeletal muscle, liver, skin, bone, and cartilage. [ 1 ] Importantly, in vivo evaluation of bioprinted constructs have shown key advantages compared to non‐printed, control samples ma... |
10. 1002/advs. 202001572 | 2,020 | Advanced Science | Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming | Abstract As an essential and fundamental process of life, cell development involves large‐scale reorganization of the 3D genome architecture, which forms the basis of gene regulation. Here, a landscape‐switching model is developed to explore the microscopic chromosomal structural origin of embryonic stem cell (ESC) dif... | 1 Introduction Cell is the basic unit of life. Cells have two essential functions. One is the division for reproduction, and the other is differentiation for multipurpose functionality. Cell differentiation has been suggested to be determined by the underlying gene regulatory network. [ 1 ] A fundamental question is ho... |
10. 1002/advs. 202001766 | 2,020 | Advanced Science | Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications | Abstract DNA computing is recognized as one of the most outstanding candidates of next‐generation molecular computers that perform Boolean logic using DNAs as basic elements. Benefiting from DNAs’ inherent merits of low‐cost, easy‐synthesis, excellent biocompatibility, and high programmability, DNA computing has evoked... | 1 Introduction In the current information technology (IT) age, silicon‐templated semiconductor computers play the predominant roles and are confirmed as essential tools for communicating, working, and even scientific research. [ 1, 2 ] However, the word “computation” was proposed much earlier than the appearance of tra... |
10. 1002/advs. 202002002 | 2,020 | Advanced Science | Modeling Endothelialized Hepatic Tumor Microtissues for Drug Screening | Abstract Compared to various traditional 2D approaches, the scaffold‐based 3D tumor models have emerged as an effective strategy to investigate the complex mechanisms behind cancer progression and responses to drug treatments, by providing biomimetic extracellular matrix and stromal‐like microenvironments including the... | 1 Introduction Over the past few decades, enormous efforts have been dedicated to exploring diverse effective preclinical screening methods toward explicitly demonstrating the pharmacological as well as toxicological attributes of various therapeutic drugs. Despite the advantages, the widely applied, traditional cell m... |
10. 1002/advs. 202002025 | 2,020 | Advanced Science | Fabrication of 3D Ordered Structures with Multiple Materials via Macroscopic Supramolecular Assembly | Abstract Integration of diverse materials into 3D ordered structures is urgently required for advanced manufacture owing to increase in demand for high‐performance products. Most additive manufacturing techniques mainly focus on simply combining different equipment, while interfacial binding of distinctive materials re... | Additive manufacture, especially three dimentional (3D) printing, is a revolutionary concept with applications in diverse fields. [ 1, 2, 3, 4 ] Owing to the increase in demand for differently processed materials with multiple functions for advanced applications such as tissue engineering, the research of additive manu... |
10. 1002/advs. 202002135 | 2,020 | Advanced Science | Engineered Plant‐Based Nanocellulose Hydrogel for Small Intestinal Organoid Growth | Abstract Organoids are three‐dimensional self‐renewing and organizing clusters of cells that recapitulate the behavior and functionality of developed organs. Referred to as “organs in a dish, ” organoids are invaluable biological models for disease modeling or drug screening. Currently, organoid culture commonly relies... | Introduction Organoids are complex 3D cell culture systems able to self‐renew and reorganize in vitro. These “mini‐organs” mimic many of the physiological properties of tissues and organs including much of their behavior and functionality. [ 1, 2 ] These attributes make organoids a robust and reliable biological model ... |
10. 1002/advs. 202002203 | 2,020 | Advanced Science | Medical Micro/Nanorobots in Precision Medicine | Abstract Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine. In this review, the current trends of medical micro and nanorobotics for therapy, surgery, diagnosis, and medical... | 1 Introduction The miniaturization of robotic platforms has the potential for advancing medical treatment and diagnosis of patients. These tiny robotic surgeons could give us access to remote and hard to reach sections of the body and perform diverse medical procedures [ 1, 2, 3, 4, 5 ] Despite the progress of medical ... |
10. 1002/advs. 202002425 | 2,021 | Advanced Science | Ice Inhibition for Cryopreservation: Materials, Strategies, and Challenges | Abstract Cryopreservation technology has developed into a fundamental and important supporting method for biomedical applications such as cell‐based therapeutics, tissue engineering, assisted reproduction, and vaccine storage. The formation, growth, and recrystallization of ice crystals are the major limitations in cel... | 1 Introduction Cryopreservation is a basic and important technique to achieve long‐term storage of organs, tissues, cells, and other biological materials by using a very low temperature (at −80 or −196 °C). [ 1, 2 ] At the cryopreserved temperature condition, the chemical and biological reactions in living cells signif... |
10. 1002/advs. 202002464 | 2,021 | Advanced Science | Bioinspired Soft Robots Based on the Moisture‐Responsive Graphene Oxide | Abstract Graphene oxide (GO), which has many oxygen functional groups, is a promising candidate for use in moisture‐responsive sensors and actuators due to the strong water–GO interaction and the ultrafast transport of water molecules within the stacked GO sheets. In the last 5 years, moisture‐responsive actuators base... | 1 Introduction Stimuli‐responsive actuators (SRAs) that directly convert environmental signals to mechanical work have been considered as key components in the development of micro‐electro‐mechanical‐systems (MEMS) and robotic devices. [ 1, 2, 3, 4, 5 ] Through their sensitive response to environmental stimuli (e. g. ,... |
10. 1002/advs. 202002489 | 2,020 | Advanced Science | Controllable Cell Deformation Using Acoustic Streaming for Membrane Permeability Modulation | Abstract Hydrodynamic force loading platforms for controllable cell mechanical deformation play an essential role in modern cell technologies. Current systems require assistance from specific microstructures thus limiting the controllability and flexibility in cell shape modulation, and studies on real‐time 3D cell mor... | 1 Introduction Living cells are always undergoing continuous internal and external mechanical forces. Response to these forces can trigger the deformation of cells, which will further influence the functions and biological properties of cells. [ 1, 2, 3, 4 ] Exogenous mechanical stimulation can regulate the growth, [ 5... |
10. 1002/advs. 202002601 | 2,020 | Advanced Science | A 3D‐Printed Self‐Adhesive Bandage with Drug Release for Peripheral Nerve Repair | Abstract Peripheral nerve injury is a common disease that often causes disability and challenges surgeons. Drug‐releasable biomaterials provide a reliable tool to regulate the nerve healing‐associated microenvironment for nerve repair. Here, a self‐adhesive bandage is designed that can form a wrap surrounding the injur... | 1 Introduction Peripheral nerve injury (PNI) is one of common diseases resulting from trauma, tumors and other illnesses, which always leads to longstanding disability with loss of motor and/or sensory function. [ 1 ] Unlike the central nervous system, the peripheral nervous system has pro‐regenerative factors, which e... |
10. 1002/advs. 202002683 | 2,021 | Advanced Science | Reconfigurable Mechanical Anisotropy in Self‐Assembled Magnetic Superstructures | Abstract Enhancement of mechanical properties in self‐assembled superstructures of magnetic nanoparticles is a new emerging aspect of their remarkable collective behavior. However, how magnetic interactions modulate mechanical properties is, to date, not fully understood. Through a comprehensive Monte Carlo investigati... | Self‐assembly of magnetic nanoparticles of different sizes and shapes has been successfully applied to design superstructured materials of novel morphologies, including helices, rods, stripes, supercubes, and labyrinths. [ 1, 2, 3, 4 ] Such magnetic superstructures have gained widespread interest owing to the extraordi... |
10. 1002/advs. 202002693 | 2,021 | Advanced Science | The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics | Abstract Neurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brai... | 1 Introduction Neural interface recording and stimulation has been demonstrated as an effective diagnosis and treatment for numerous neurological disorders. [ 1 ] With an emphasis on building closed‐loop systems, modern neural probes must incorporate both these functionalities while addressing the disparate design requ... |
10. 1002/advs. 202003074 | 2,020 | Advanced Science | Advancing Versatile Ferroelectric Materials Toward Biomedical Applications | Abstract Ferroelectric materials (FEMs), possessing piezoelectric, pyroelectric, inverse piezoelectric, nonlinear optic, ferroelectric‐photovoltaic, and many other properties, are attracting increasing attention in the field of biomedicine in recent years. Because of their versatile ability of interacting with force, h... | 1 Introduction Human bodies can sense and respond to different physical cues from the surrounding environment and perform physiological activities correspondingly. Over the past years considerable efforts have been made to utilize physical stimuli to understand and manipulate biological processes. For instance, in term... |
10. 1002/advs. 202003119 | 2,021 | Advanced Science | Therapeutic Biomaterial Approaches to Alleviate Chronic Limb Threatening Ischemia | Abstract Chronic limb threatening ischemia (CLTI) is a severe condition defined by the blockage of arteries in the lower extremities that leads to the degeneration of blood vessels and is characterized by the formation of non‐healing ulcers and necrosis. The gold standard therapies such as bypass and endovascular surge... | 1 Introduction Chronic limb threatening ischemia (CLTI) is a peripheral vascular disease that occurs with the occlusion of arteries of the lower extremities, mainly due to the formation of the atherosclerotic plaque. [ 1 ] CLTI has an incidence of 500–1000 new cases per million individuals every year in Western society... |
10. 1002/advs. 202003129 | 2,021 | Advanced Science | Proteinaceous Hydrogels for Bioengineering Advanced 3D Tumor Models | Abstract The establishment of tumor microenvironment using biomimetic in vitro models that recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is in high demand for accelerating the discovery and preclinical validation of more effective anticancer therapeutics. To date, ECM‐mimeti... | 1 Introduction Cancer is currently the second leading cause of death worldwide, requiring that pharmaceutical and biotechnological industries invest a significant amount of resources and effort every year in the discovery and development of more promising therapeutics. However, the attrition rates of most candidate the... |
10. 1002/advs. 202003177 | 2,021 | Advanced Science | Melt Electrospinning Writing of Magnetic Microrobots | Abstract The magnetic microrobots actuated by an external magnetic field can access distant, enclosed, and small spaces under fuel‐free conditions, which is apromising technology for manipulation and delivery under microenvironment; however, the complicated fabrication method limits their applications. Herein, three te... | 1 Introduction Microrobots were reported with high expectations for inspection and exploration tasks, [ 1 ] micro‐unmanned air vehicles, [ 2 ] minimally invasive medical procedures, [ 3 ] and targeted drug delivery. [ 4 ] Different types of motors driven by ultrasound, [ 5 ] light, [ 6 ] thermal, [ 7 ] bubbles, [ 8 ] a... |
10. 1002/advs. 202003186 | 2,021 | Advanced Science | Precision Surface Microtopography Regulates Cell Fate via Changes to Actomyosin Contractility and Nuclear Architecture | Abstract Cells are able to perceive complex mechanical cues from their microenvironment, which in turn influences their development. Although the understanding of these intricate mechanotransductive signals is evolving, the precise roles of substrate microtopography in directing cell fate is still poorly understood. He... | 1 Introduction Understanding how mechanical or physical cues in the extracellular environment invoke a cellular response has developed as a key topic of interest in recent years. It is well documented that cells generate traction forces induced by cytoskeletal tension, [ 1, 2 ] and that through the application of micro... |
10. 1002/advs. 202003273 | 2,021 | Advanced Science | A Fast Alternative to Soft Lithography for the Fabrication of Organ‐on‐a‐Chip Elastomeric‐Based Devices and Microactuators | Abstract Organ‐on‐a‐chip technology promises to revolutionize how pre‐clinical human trials are conducted. Engineering an in vitro environment that mimics the functionality and architecture of human physiology is essential toward building better platforms for drug development and personalized medicine. However, the com... | 1 Introduction Microfluidic devices are well established as experimental platforms in life sciences. Devices designed for cell sorting, DNA sequencing, electrophoresis, 3D cell culture are just a few examples of what can be achieved at the microscale. [ 1, 2 ] Miniaturization of biological procedures has many advantage... |
10. 1002/advs. 202003332 | 2,021 | Advanced Science | Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion | Abstract Epithelial, stem‐cell derived organoids are ideal building blocks for tissue engineering, however, scalable and shape‐controlled bio‐assembly of epithelial organoids into larger and anatomical structures is yet to be achieved. Here, a robust organoid engineering approach, Multi‐Organoid Patterning and Fusion (... | 1 Introduction Engineered fusion of multicellular materials, such as spheroids and organoids, represents a biomimetic cell assembly process fundamental to the fields of biofabrication, tissue engineering and in vitro tissue modelling, [ 1, 2, 3 ] Organization and fusion of cell aggregates to achieve prescribed shapes (... |
10. 1002/advs. 202003387 | 2,021 | Advanced Science | Synergistic Ice Inhibition Effect Enhances Rapid Freezing Cryopreservation with Low Concentration of Cryoprotectants | Abstract Despite recent advances in controlling ice formation and growth, it remains a challenge to design anti‐icing materials in various fields from atmospheric to biological cryopreservation. Herein, tungsten diselenide (WSe 2 )‐polyvinyl pyrrolidone (PVP) nanoparticles (NPs) are synthesized through one‐step solvoth... | 1 Introduction Water is a fundamental element for all life on earth and will turn into ice when the temperature is below the freezing point. However, ice formation on materials surface causes serious threat to the activities of human beings, ranging from technological applications to economic fields. [ 1, 2, 3, 4, 5, 6... |
10. 1002/advs. 202003390 | 2,021 | Advanced Science | Crosstalk between Bone and Nerves within Bone | Abstract For the past two decades, the function of intrabony nerves on bone has been a subject of intense research, while the function of bone on intrabony nerves is still hidden in the corner. In the present review, the possible crosstalk between bone and intrabony peripheral nerves will be comprehensively analyzed. P... | 1 Introduction Studies on the intersection of bone mass, body weight, and gonadal function in the early 2000s provided insight on how the neural system regulates bone remodeling. Augmentation of vertebral trabecular bone mass was identified in obese mice and hypogonadic ones that were deficient in leptin or its recepto... |
10. 1002/advs. 202003535 | 2,021 | Advanced Science | MgFe‐LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self‐Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells | Abstract Leukemia inhibitory factor (LIF), an indispensable bioactive protein that sustains self‐renewal and pluripotency in stem cells, is vital for mouse embryonic stem cell (mESC) culture. Extensive research is conducted on reliable alternatives for LIF as its clinical application in stable culture and large‐scale e... | 1 Introduction Embryonic stem cells (ESCs) are characterized by self‐renewal and pluripotency. They have been successfully differentiated into several cell types—including nerve cells, retinal pigmented epithelium, cardiomyocytes, islet cells, and liver cells—that are used in the therapy of spinal cord injury, [ 1, 2 ]... |
10. 1002/advs. 202003699 | 2,022 | Advanced Science | Ocular Nanomedicine | Abstract Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechno... | 1 Introduction The human eye is an exclusive and intricate organ of the visual senses. [ 1 ] Anatomically, the human eye includes unique physiological barriers, including the tear film, cornea, and conjunctival barriers constituting the anterior segment barriers, and the inner limiting membrane and blood‐retinal barrie... |
10. 1002/advs. 202003701 | 2,021 | Advanced Science | Reversible Deactivation Radical Polymerization: From Polymer Network Synthesis to 3D Printing | Abstract 3D printing has changed the fabrication of advanced materials as it can provide customized and on‐demand 3D networks. However, 3D printing of polymer materials with the capacity to be transformed after printing remains a great challenge for engineers, material, and polymer scientists. Radical polymerization ha... | 1 Introduction Polymer networks can be formed in bulk, solution or using 3D printing and they can be classified into four main categories: thermosets, thermoplastics, elastomers, and gels. [ 1 ] Recent advances in the field of polymer networks have conferred new properties, for instance, self‐healing, ultrahigh permane... |
10. 1002/advs. 202003708 | 2,021 | Advanced Science | Local Immunomodulatory Strategies to Prevent Allo‐Rejection in Transplantation of Insulin‐Producing Cells | Abstract Islet transplantation has shown promise as a curative therapy for type 1 diabetes (T1D). However, the side effects of systemic immunosuppression and limited long‐term viability of engrafted islets, together with the scarcity of donor organs, highlight an urgent need for the development of new, improved, and sa... | 1 Introduction 1. 1 Background of Type 1 Diabetes Type 1 diabetes (T1D) is an autoimmune disease which affects millions of people worldwide and causes tremendous economic and societal burdens. [ 1 ] T1D onset occurs when a patient's own immune system attacks pancreatic β cells, resulting in the deficiency of insulin, a... |
10. 1002/advs. 202003738 | 2,021 | Advanced Science | A Stretchable Scaffold with Electrochemical Sensing for 3D Culture, Mechanical Loading, and Real‐Time Monitoring of Cells | Abstract In the field of three‐dimensional (3D) cell culture and tissue engineering, great advance focusing on functionalized materials and desirable culture systems has been made to mimic the natural environment of cells in vivo. Mechanical loading is one of the critical factors that affect cell/tissue behaviors and m... | 1 Introduction Cells in vivo reside in a three‐dimensional (3D) dynamic microenvironment consisting of soluble factors, cell‐matrix interactions, cell–cell contacts, and specific physicochemical properties. [ 1 ] Over the past decades, to better mimic such physiological conditions in vivo, 3D cell culture systems have ... |
10. 1002/advs. 202003751 | 2,021 | Advanced Science | 3D Tissue and Organ Printing—Hope and Reality | Abstract Three‐dimensional (3D) bioprinting is an emerging, groundbreaking strategy in tissue engineering, allowing the fabrication of living constructs with an unprecedented degree of complexity and accuracy. While this technique greatly facilitates the structuring of native tissue‐like architectures, many challenges ... | 1 Introduction Since ancient times, humans have been fascinated by the unimaginable complexity of living creatures. The orchestrated function of multiple structures with incredible geometries ignited the imagination of our ancestors, making them raise existential questions. The invention of the microscope further enhan... |
10. 1002/advs. 202003937 | 2,021 | Advanced Science | Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges | Abstract Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain is severely hampered by the presence of the blood–brain barrier (BBB). Drug delivery systems have been extensively explored in recent decades aiming to... | 1 Introduction 1. 1 Neurological Disorders Neurological disorders that affect the brain and spinal cord are leading causes of morbidity and disability globally, with stroke being the second most common cause of death. [ 1 ] Common neurological disorders include Alzheimer's disease, Parkinson's disease, Huntington's dis... |
10. 1002/advs. 202004000 | 2,021 | Advanced Science | The Dynamic Counterbalance of RAC1‐YAP/OB‐Cadherin Coordinates Tissue Spreading with Stem Cell Fate Patterning | Abstract Tissue spreading represents a key morphogenetic feature of embryonic development and regenerative medicine. However, how molecular signaling orchestrates the spreading dynamics and cell fate commitment of multicellular tissue remains poorly understood. Here, it is demonstrated that the dynamic counterbalance b... | Tissue spreading over a substratum is a fundamental morphogenetic phenomenon in numerous physiological and pathological processes. [ 1 ] Examples include the development of the embryo, which requires the orchestrated movement of the blastoderm over the yolk sac to shape the body plan of multicellular creatures. [ 1b, c... |
10. 1002/advs. 202004014 | 2,021 | Advanced Science | Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management | Abstract The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally‐administered medications against diseases affecting these oral milieus ma... | 1 Introduction For a long time, systemic administration has been the most important route for delivery of drugs for treating oral diseases. This pathway of drug administration produces problems such as drug resistance and dysbiosis, as well as adverse side effects on tissues and organs unrelated to the targeted tissue.... |
10. 1002/advs. 202004082 | 2,021 | Advanced Science | Advanced Switchable Molecules and Materials for Oil Recovery and Oily Waste Cleanup | Abstract Advanced switchable molecules and materials have shown great potential in numerous applications. These novel materials can express different states of physicochemical properties as controlled by a designated stimulus, such that the processing condition can always be maintained in an optimized manner for improv... | 1 Introduction 1. 1 Motivations in Oil Recovery Applications Recovering oil from natural resources is one of the essential activities in human society. Currently, oil recovery is mostly referred to as the extraction of petroleum hydrocarbons that exist in various forms, including light oil, heavy crude, offshore oil re... |
10. 1002/advs. 202004205 | 2,021 | Advanced Science | One‐Step 3D Printing of Heart Patches with Built‐In Electronics for Performance Regulation | Abstract Three dimensional (3D) printing of heart patches usually provides the ability to precisely control cell location in 3D space. Here, one‐step 3D printing of cardiac patches with built‐in soft and stretchable electronics is reported. The tissue is simultaneously printed using three distinct bioinks for the cells... | 1 Introduction Cardiac tissue engineering has emerged as a promising therapy to regenerate the diseased heart. In this approach, rather than simply introducing cells into the diseased area to repopulate the injured heart and restore function, the cells are seeded in or onto 3D biomaterials prior to transplantation. The... |
10. 1002/advs. 202004213 | 2,021 | Advanced Science | Nanostructured Dense Collagen‐Polyester Composite Hydrogels as Amphiphilic Platforms for Drug Delivery | Abstract Associating collagen with biodegradable hydrophobic polyesters constitutes a promising method for the design of medicated biomaterials. Current collagen‐polyester composite hydrogels consisting of pre‐formed polymeric particles encapsulated within a low concentrated collagen hydrogel suffer from poor physical ... | 1 Introduction Collagen is the most abundant protein in the mammalian world and benefits from a wide popularity in tissue engineering thanks to its biocompatibility, biodegradability, and capability to promote cell adhesion and proliferation. [ 1, 2 ] It can be applied in the form of film, [ 3, 4 ] hydrogel, [ 5, 6 ] o... |
10. 1002/advs. 202004226 | 2,021 | Advanced Science | Long‐Term Imaging of Wound Angiogenesis with Large Scale Optoacoustic Microscopy | Abstract Wound healing is a well‐coordinated process, necessitating efficient formation of new blood vessels. Vascularization defects are therefore a major risk factor for chronic, non‐healing wounds. The dynamics of mammalian tissue revascularization, vessel maturation, and remodeling remain poorly understood due to l... | 1 Introduction Skin reacts to injury via a well‐coordinated healing process, which follows four overlapping phases, namely hemostasis, inflammation, proliferation, and remodeling. The skin microvasculature plays a central role in each regeneration phase, as it controls blood flow to the site of injury. This allows dist... |
10. 1002/advs. 202004393 | 2,021 | Advanced Science | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities | Abstract Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to ... | 1 Introduction Cell is the basic unit for all living organisms. The cell membrane acts as a barrier to prevent the free entry of extracellular substances into the cell, which ensures the relative stability of the intracellular environment. [ 1 ] Nevertheless, to maintain a sequence of biochemical reactions inside the c... |
10. 1002/advs. 202004506 | 2,021 | Advanced Science | A High‐Resolution Ternary Model Demonstrates How PEGylated 2D Nanomaterial Stimulates Integrin | Abstract Bio–nano interfaces are integral to all applications of nanomaterials in biomedicine. In addition to peptide‐ligand‐functionalized nanomaterials, passivation on 2D nanomaterials has emerged as a new regulatory factor for integrin activation. However, the mechanisms underlying such ligand‐independent processes ... | 1 Introduction Bio–nano interfaces are established when nanomaterials interact with biological components, such as cells, proteins, and membranes, [ 1, 2 ] and comprise a series of time‐dependent dynamic interactions, which dominate the physicochemical reactions, kinetics, and thermodynamic exchanges between the surfac... |
10. 1002/advs. 202004586 | 2,021 | Advanced Science | Smart Cargo Delivery System based on Mesoporous Nanoparticles for Bone Disease Diagnosis and Treatment | Abstract Bone diseases constitute a major issue for modern societies as a consequence of progressive aging. Advantages such as open mesoporous channel, high specific surface area, ease of surface modification, and multifunctional integration are the driving forces for the application of mesoporous nanoparticles (MNs) i... | 1 Introduction Bone diseases, such as bone cancer (e. g. , osteosarcoma, bone metastasis), bone infection, osteoporosis, osteoarthritis (OA), and nonunion defects constitute a major issue that threatens public health as a consequence of progressive aging of bone. [ 1 ] Autografts and allografts are regarded as the most... |
10. 1002/advs. 202004616 | 2,021 | Advanced Science | Cell‐Laden Multiple‐Step and Reversible 4D Hydrogel Actuators to Mimic Dynamic Tissue Morphogenesis | Abstract Shape‐morphing hydrogels bear promising prospects as soft actuators and for robotics. However, they are mostly restricted to applications in the abiotic domain due to the harsh physicochemical conditions typically necessary to induce shape morphing. Here, multilayer hydrogel actuator systems are developed usin... | 1 Introduction Continuous changes in tissue and organ architecture, such as reorganization, [ 1 ] remodeling, [ 2 ] and morphogenesis, [ 3 ] occur throughout development. [ 4 ] The resulting shapes of tissues and relative positions of different cell types, extracellular matrix molecules, and soluble factors ultimately ... |
10. 1002/advs. 202004699 | 2,021 | Advanced Science | Hybrid Living Capsules Autonomously Produced by Engineered Bacteria | Abstract Bacterial cellulose (BC) has excellent material properties and can be produced sustainably through simple bacterial culture, but BC‐producing bacteria lack the extensive genetic toolkits of model organisms such as Escherichia coli ( E. coli ). Here, a simple approach is reported for producing highly programmab... | 1 Introduction Living systems have evolved the ability to produce materials—from bacterial biofilms to skeletal tissue—that can respond to environmental cues, self‐regenerate, and dynamically alter their physical properties. There is great potential for the development of engineered living materials (ELMs) with these s... |
10. 1002/advs. 202004819 | 2,021 | Advanced Science | Recent Advances in Ionic Liquids in Biomedicine | Abstract The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of dru... | 1 Introduction Ionic liquids (ILs) are defined as solvents that consist of bulky and asymmetric organic anions and cations that exist as liquids below 100 °C. Deep eutectic solvents (DES) are defined as materials that, once combined, experience a depression in the melting point due predominantly to the formation of hyd... |
10. 1002/advs. 202100126 | 2,021 | Advanced Science | Tailoring Materials with Specific Wettability in Biomedical Engineering | Abstract As a fundamental feature of solid surfaces, wettability is playing an increasingly important role in our daily life. Benefitting from the inspiration of biological paradigms and the development in manufacturing technology, numerous wettability materials with elaborately designed surface topology and chemical c... | 1 Introduction As a common phenomenon in our daily life, the wettability of solid surfaces, which is determined by the interfacial interaction among solid, liquid, and gas phases, has attracted great attention and been extensively investigated. The concept of wettability and contact angle (CA) can be traced back to You... |
10. 1002/advs. 202100216 | 2,021 | Advanced Science | Smart and Functionalized Development of Nucleic Acid‐Based Hydrogels: Assembly Strategies, Recent Advances, and Challenges | Abstract Nucleic acid‐based hydrogels that integrate intrinsic biological properties of nucleic acids and mechanical behavior of their advanced assemblies are appealing bioanalysis and biomedical studies for the development of new‐generation smart biomaterials. It is inseparable from development and incorporation of no... | 1 Introduction Over nearly four decades of development, DNA nanotechnology has driven the generation and progress of a cluster of subdisciplines, especially taking a big step in the biomaterial science direction [ 1 ] ( Figure 1 ). In the early 1980s, the groundbreaking study of Seeman established a solid foundation fo... |
10. 1002/advs. 202100363 | 2,021 | Advanced Science | Calcium–Collagen Coupling is Vital for Biomineralization Schedule | Abstract Biomineralization is a chemical reaction that occurs in organisms in which collagen initiates and guides the growth and crystallization of matched apatite minerals. However, there is little known about the demand pattern for calcium salts and collagen needed by biomineralization. In this study, natural bone bi... | 1 Introduction In bone tissue engineering, the promotion of new bone formation similar to that of the original is still the highest goal of bone repair. Numerous bone substitute materials have been designed to regenerate the impaired bone structure. These include bone bioceramics, mesoporous scaffolds, mineralized coll... |
10. 1002/advs. 202100368 | 2,021 | Advanced Science | Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies | Abstract Healthcare‐acquired infections as well as increasing antimicrobial resistance have become an urgent global challenge, thus smart alternative solutions are needed to tackle bacterial infections. Antibacterial materials in biomedical applications and hospital hygiene have attracted great interest, in particular,... | 1 Introduction Bacteria, widely found in human living and working environments, is one type of the oldest specie on the earth. [ 1 ] While most of the bacteria are harmless to human health, bacteria such as Staphylococcus aureus, Helicobacter pylori, Escherichia coli, and Bacillus pestis can invade the host and cause v... |
10. 1002/advs. 202100446 | 2,021 | Advanced Science | Toward a Better Regeneration through Implant‐Mediated Immunomodulation: Harnessing the Immune Responses | Abstract Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early‐stage response to tissue damages. These cells break down extracellular matrix, clear debris, and secr... | 1 Introduction Tissue/organ dysfunction suffering from aging, [ 1, 2 ] injuries, [ 3, 4, 5, 6, 7 ] and diseases [ 8, 9 ] presents a serious threat to human health, and leads to a high demand for organ transplantation. [ 10, 11, 12 ] Organ transplantation is one of the strongest medical field practices to combat this pr... |
10. 1002/advs. 202100627 | 2,021 | Advanced Science | All‐Optical and Label‐Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials | Abstract Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio‐temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing ... | 1 Introduction Cellular activity stimulation is a pivotal technique for restoring the physiological heart contraction, for exploring the electrical functionality of cardiac and neuronal cells in vitro, for investigating the effects of molecular entities on the cells, and for the treatment of patient's cardiovascular or... |
10. 1002/advs. 202100798 | 2,021 | Advanced Science | In Vitro Strategies to Vascularize 3D Physiologically Relevant Models | Abstract Vascularization of 3D models represents a major challenge of tissue engineering and a key prerequisite for their clinical and industrial application. The use of prevascularized models built from dedicated materials could solve some of the actual limitations, such as suboptimal integration of the bioconstructs ... | 1 Introduction In physiological conditions, the tissues of the human body are vascularized thanks to an abundant network of blood vessels, known as the vascular network. Human vasculature has essential biological functions, such as nutrients and gas exchange, metabolic waste removal, and homeostasis maintenance. [ 1, 2... |
10. 1002/advs. 202100820 | 2,021 | Advanced Science | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes | Abstract Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation ... | 1 Introduction Transplantation of stem cell derived insulin producing cells is a promising treatment option for the reversal of Type 1 Diabetes (T1D). [ 1, 2, 3 ] However, successful islet transplantation remains challenging due to the host immune response, and long‐term modulation of this response with immunosuppressa... |
10. 1002/advs. 202100894 | 2,021 | Advanced Science | 3D Printed Wesselsite Nanosheets Functionalized Scaffold Facilitates NIR‐II Photothermal Therapy and Vascularized Bone Regeneration | Abstract Various bifunctional scaffolds have recently been developed to address the reconstruction of tumor‐initiated bone defects. Such scaffolds are usually composed of a near‐infrared (NIR) photothermal conversion agent and a conventional bone scaffold for photothermal therapy (PTT) and long‐term bone regeneration. ... | 1 Introduction Bone related malignancies, including primary bone cancer (osteosarcoma, chondrosarcoma, fibrosarcoma, etc. ) and bone metastatic cancer (primary tumors in breast, lung, kidney, etc. ) seriously threaten the patient's survival. [ 1 ] Although surgical treatment combined with adjuvant chemotherapy in the c... |
10. 1002/advs. 202100961 | 2,021 | Advanced Science | Versatile Mitogenic and Differentiation‐Inducible Layer Formation by Underwater Adhesive Polypeptides | Abstract Artificial materials have no biological functions, but they are important for medical devices such as artificial organs and matrices for regenerative medicine. In this study, mitogenic and differentiation‐inducible materials are devised via the simple coating of polypeptides, which contain the sequence of epid... | 1 Introduction Various biomaterials, including organic and inorganic matters, have been developed for artificial organs or tissue engineering. Non‐biofouling or cell‐adhesive surfaces have been devised for use in the human body. However, the addition of biological activity to biomaterials—such as growth enhancement—is ... |
10. 1002/advs. 202100962 | 2,021 | Advanced Science | Wireless Localized Electrical Stimulation Generated by an Ultrasound‐Driven Piezoelectric Discharge Regulates Proinflammatory Macrophage Polarization | Abstract Proinflammatory (M1) macrophages play a vital role in antitumor immunity, and regulation of proinflammatory macrophage polarization is critical for immunotherapy. The polarization of macrophages can be regulated by biological or chemical stimulation, but investigations of the regulatory effect of physical stim... | 1 Introduction Innate immune cells play a critical role in many biological processes and disease therapies, especially tumor immunotherapy. [ 1, 2, 3 ] Macrophages are one of the most important innate immune cells and have different polarization states, [ 4, 5 ] including the proinflammatory (M1) phenotype and anti‐inf... |
10. 1002/advs. 202100964 | 2,021 | Advanced Science | Rejuvenation of Senescent Bone Marrow Mesenchymal Stromal Cells by Pulsed Triboelectric Stimulation | Abstract Stem cell senescence contributes to stem cell exhaustion and drives various aging‐associated disorders. However, strategies to rejuvenate senescent stem cells are limited. The present study proposes an approach based on triboelectric stimulation to rejuvenate senescent bone marrow mesenchymal stromal cells (BM... | 1 Introduction Aging is a complex physiological process that can lead to the degeneration and dysfunction of multiple tissues and organs. [ 1 ] Stem cells are prone to senescence during organismal aging owing to profound age‐related changes in stem cell niches and intracellular biological dysfunctions. [ 2 ] Recently, ... |
10. 1002/advs. 202100968 | 2,021 | Advanced Science | Design and Synthesis of Quick Setting Nonswelling Hydrogels via Brush Polymers | Abstract Brush polymers have emerged as components of novel materials that show huge potential in multiple disciplines and applications, including self‐assembling photonic crystals, drug delivery vectors, biomimetic lubricants, and ultrasoft elastomers. However, an understanding of how this unique topology can affect t... | 1 Introduction Hydrogels are ubiquitous in both biomedicine (e. g. , wound dressings, tissue engineering scaffolds, and surgical adhesives) and device engineering (e. g. , electronics coatings, adhesives, and soft robotics). [ 1, 2 ] A broad range of polymer species and network structures have been used to tailor the p... |
10. 1002/advs. 202101027 | 2,021 | Advanced Science | Compressive Buckling Fabrication of 3D Cell‐Laden Microstructures | Abstract Tissue architecture is a prerequisite for its biological functions. Recapitulating the three‐dimensional (3D) tissue structure represents one of the biggest challenges in tissue engineering. Two‐dimensional (2D) tissue fabrication methods are currently in the main stage for tissue engineering and disease model... | 1 Introduction Native tissue is composed of multiple types of cells and extracellular matrix (ECM) that are organized into complex spatial patterns. This highly specialized architecture of living tissues is critical for their biological functions during tissue homeostasis, regeneration, and embryonic development. [ 1, ... |
10. 1002/advs. 202101090 | 2,021 | Advanced Science | Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier | Abstract The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain. An intact BBB is also critical for the maintenance of normal neuronal function. In cerebral vascular disea... | 1 Introduction The existence of a special barrier in the brain was noticed in the late 19th century, as particular chemical dyes were excluded from the brain while staining other body tissues. [ 1 ] In the early 1920s, this barrier was further defined as the blood–brain barrier (BBB). [ 2 ] However, the structure of th... |
10. 1002/advs. 202101233 | 2,021 | Advanced Science | Integrating Emerging Polymer Chemistries for the Advancement of Recyclable, Biodegradable, and Biocompatible Electronics | Abstract Through advances in molecular design, understanding of processing parameters, and development of non‐traditional device fabrication techniques, the field of wearable and implantable skin‐inspired devices is rapidly growing interest in the consumer market. Like previous technological advances, economic growth a... | 1 Introduction As we become increasingly dependent on consumer plastics and electronics, it is highly desirable for these materials to be seamlessly integrated with the environment and human health. Their harmonious integration into our ecosystem relies on the design of materials to be recyclable, degradable in environ... |
10. 1002/advs. 202101394 | 2,021 | Advanced Science | 3D Printing of Physical Organ Models: Recent Developments and Challenges | Abstract Physical organ models are the objects that replicate the patient‐specific anatomy and have played important roles in modern medical diagnosis and disease treatment. 3D printing, as a powerful multi‐function manufacturing technology, breaks the limitations of traditional methods and provides a great potential f... | 1 Introduction In the clinical treatment of many diseases, how to better simulate and represent the disease states is the content that people always care about. Simple models to simulate the anatomy and pathological properties of organs have been used in medicine for centuries, such as clay and stone models of humans w... |
10. 1002/advs. 202101739 | 2,021 | Advanced Science | Ultrathin 2D Inorganic Ancient Pigment Decorated 3D‐Printing Scaffold Enables Photonic Hyperthermia of Osteosarcoma in NIR‐II Biowindow and Concurrently Augments Bone Regeneration | Abstract Osteosarcoma (OS) is the primary malignant bone tumor. Despite therapeutic strategies including surgery, chemotherapy, and radiotherapy have been introduced into the war of fighting OS, the 5‐year survival rate for patients still remains unchangeable for decades. Besides, the critical bone defects after surger... | 1 Introduction Osteosarcoma (OS) is the primary malignant bone tumor, which mainly develops in children/adolescents (0–19 years old) and older adults (> 65 years old) suffered from Paget's disease of bone or radiation. [ 1 ] Despite therapeutic strategies including surgery, chemotherapy, and radiotherapy have been intr... |
10. 1002/advs. 202101837 | 2,021 | Advanced Science | Parallels between the Developing Vascular and Neural Systems: Signaling Pathways and Future Perspectives for Regenerative Medicine | Abstract Neurovascular disorders, which involve the vascular and nervous systems, are common. Research on such disorders usually focuses on either vascular or nervous components, without looking at how they interact. Adopting a neurovascular perspective is essential to improve current treatments. Therefore, comparing m... | 1 Introduction The vascular and nervous systems, respectively taking care of blood transport and coordinating sensory and motor information, are essential to the human body and share many similarities. The first begins developing very early after gastrulation. The heart arises from an area of the mesoderm known as the ... |
10. 1002/advs. 202102156 | 2,021 | Advanced Science | Stretchable and Conductive Composite Structural Color Hydrogel Films as Bionic Electronic Skins | Abstract Electronic skins have received increasing attention in biomedical areas. Current efforts about electronic skins are focused on the development of multifunctional materials to improve their performance. Here, the authors propose a novel natural‐synthetic polymers composite structural color hydrogel film with hi... | 1 Introduction As an essential part of artificial intelligence, electronic skins have received increasing attention and achieved remarkable progress in motion and health monitoring, disease diagnosis, implantable devices, soft robots, and so on. [ 1 ] Thus, considerable research efforts are committed to developing nove... |
10. 1002/advs. 202102540 | 2,021 | Advanced Science | Fundamentals and Design‐Led Synthesis of Emulsion‐Templated Porous Materials for Environmental Applications | Abstract Emulsion templating is at the forefront of producing a wide array of porous materials that offers interconnected porous structure, easy permeability, homogeneous flow‐through, high diffusion rates, convective mass transfer, and direct accessibility to interact with atoms/ions/molecules throughout the exterior ... | 1 Introduction 1. 1 Demand of Porous Materials for Environmental Applications Despite the amazing merits of the development in science and technology for the advancement of human society, it is also associated with severe environmental concerns pertaining to population growth‐oriented rapid industrialization and rising... |
10. 1002/advs. 202102545 | 2,021 | Advanced Science | Living Bacterial Hydrogels for Accelerated Infected Wound Healing | Abstract Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial bacteria, thus destroying the balance of the damaged skin microbial ecosystem. Her... | 1 Introduction The skin plays an extremely important role in preventing water loss and blocking the invasion of harmful substances and pathogenic microorganisms as a significant interface between the body and its surroundings, where a variety of microbial communities co‐exist, including bacteria, fungi, and viruses. [ ... |
10. 1002/advs. 202102557 | 2,021 | Advanced Science | A General Protein Unfolding‐Chemical Coupling Strategy for Pure Protein Hydrogels with Mechanically Strong and Multifunctional Properties | Abstract Protein‐based hydrogels have attracted great attention due to their excellent biocompatible properties, but often suffer from weak mechanical strength. Conventional strengthening strategies for protein‐based hydrogels are to introduce nanoparticles or synthetic polymers for improving their mechanical strength,... | 1 Introduction Proteins as intricate macromolecules must fold into very delicate and precise conformations to achieve their biological activities. Due to their unique folding structures, functions, and chemistries, native proteins are often considered as biocompatible building blocks for developing new protein‐based bi... |
10. 1002/advs. 202102627 | 2,021 | Advanced Science | Injectable, Pore‐Forming, Perfusable Double‐Network Hydrogels Resilient to Extreme Biomechanical Stimulations | Abstract Biological tissues hinge on blood perfusion and mechanical toughness to function. Injectable hydrogels that possess both high permeability and toughness have profound impacts on regenerative medicine but remain a long‐standing challenge. To address this issue, injectable, pore‐forming double‐network hydrogels ... | 1 Introduction Injectable hydrogels can be delivered via needle–syringe injection into the human body with low invasiveness. [ 1, 2 ] They have found significant use in many branches of medicine, including drug/cell delivery, tissue engineering, biofabrication, organs on chips, and disease modeling. Despite extensive e... |
10. 1002/advs. 202102662 | 2,021 | Advanced Science | Recent Progress in Active Mechanical Metamaterials and Construction Principles | Abstract Active mechanical metamaterials (AMMs) (or smart mechanical metamaterials) that combine the configurations of mechanical metamaterials and the active control of stimuli‐responsive materials have been widely investigated in recent decades. The elaborate artificial microstructures of mechanical metamaterials and... | 1 Introduction By periodically arranging customized artificial microstructure units, mechanical metamaterials have extraordinary properties that do not exist in natural materials. Typical mechanical metamaterials include stiffness designable metamaterials, [ 1, 2 ] pentamode metamaterials, [ 3, 4, 5, 6 ] negative Poiss... |
10. 1002/advs. 202102678 | 2,021 | Advanced Science | Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation | Abstract Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass ... | 1 Introduction As the second leading cause of death worldwide, cancer is a complex disease group that is still largely incurable. [ 1 ] Multiple strategies, including surgery, chemotherapy, radiotherapy, hormone therapy, and targeted therapies, have been developed due to high mortality and morbidity resulting from canc... |
10. 1002/advs. 202102698 | 2,021 | Advanced Science | Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds | Abstract Patients with Alagille syndrome carry monogenic mutations in the Notch signaling pathway and face complications such as jaundice and cholestasis. Given the presence of intrahepatic ductopenia in these patients, Notch2 receptor signaling is implicated in driving normal biliary development and downstream branchi... | 1 Introduction The liver is the largest internal organ in the body and is responsible for performing over 500 different vital functions. These tasks include detoxifying drugs, storing nutrients, and producing essential factors such as albumin, clotting proteins, and bile. At a microscopic view, the liver organization c... |
10. 1002/advs. 202102741 | 2,021 | Advanced Science | Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy | Abstract Supramolecular self‐assemblies of dendritic peptides with well‐organized nanostructures have great potential as multifunctional biomaterials, yet the complex self‐assembly mechanism hampers their wide exploration. Herein, a self‐stabilized supramolecular assembly (SSA) constructed from a PEGylated dendritic pe... | 1 Introduction Supramolecular peptides can be used to create a myriad of well‐organized structures with advanced functions, and they have great potential in biomedicine. [ 1 ] By tailoring the sequences and external stimuli, peptide can be self‐assembled into micelles, vesicles, spheres, fibers, and tubes driven by sup... |
10. 1002/advs. 202102908 | 2,021 | Advanced Science | Scaffolding Biomaterials for 3D Cultivated Meat: Prospects and Challenges | Abstract Cultivating meat from stem cells rather than by raising animals is a promising solution to concerns about the negative externalities of meat production. For cultivated meat to fully mimic conventional meat's organoleptic and nutritional properties, innovations in scaffolding technology are required. Many scaff... | 1 Introduction Large‐scale conventional animal agriculture is associated with a host of environmental and public health issues. Primarily due to the increase in close human–animal contacts from animal agriculture, destruction of wildlife habitats, and rising human population and global mobility, 75% of new infectious d... |
10. 1002/advs. 202102919 | 2,021 | Advanced Science | Injectable Nanocomposite Implants Reduce ROS Accumulation and Improve Heart Function after Infarction | Abstract In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of one of the coronary arteries, leading to ischemia, which further triggers the generation of reactive oxygen species (ROS). These sequential processes eventually lead to the death of contractile cells and affect the i... | 1 Introduction Cardiovascular diseases account for 34% of all deaths in the United States with costs in excess of $500 billion annually. [ 1 ] Myocardial infarction (MI) account for a significant segment of this population and is associated with sudden death, as well significant morbidity and mortality. [ 1, 2 ] In MI,... |
10. 1002/advs. 202103098 | 2,021 | Advanced Science | Hierarchically Multivalent Peptide–Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion | Abstract The multivalent binding effect has been the subject of extensive studies to modulate adhesion behaviors of various biological and engineered systems. However, precise control over the strong avidity‐based binding remains a significant challenge. Here, a set of engineering strategies are developed and tested to... | 1 Introduction The majority of biological events (e. g. , protein folding, signal transduction, material transport, and viral infection) occur through binding/unbinding processes among biological substances. [ 1 ] Such binding events often utilize co‐operative interactions, also known as multivalent interactions, to ex... |
10. 1002/advs. 202103284 | 2,021 | Advanced Science | Acceleration of Bone Regeneration Induced by a Soft‐Callus Mimetic Material | Abstract Clinical implementation of endochondral bone regeneration (EBR) would benefit from the engineering of devitalized cartilaginous constructs of allogeneic origins. Nevertheless, development of effective devitalization strategies that preserves extracellular matrix (ECM) is still challenging. The aim of this stud... | 1 Introduction Over the last years, an interest has grown in the use of decellularized and devitalized extracellular matrices as bioactive scaffolds for in situ tissue engineering (TE). [ 1 ] These decellularization and devitalization processes entail the killing of resident cells while preserving the bioactive compone... |
10. 1002/advs. 202103320 | 2,021 | Advanced Science | Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model | Abstract While decades of research have enriched the knowledge of how to grow cells into mature tissues, little is yet known about the next phase: fusing of these engineered tissues into larger functional structures. The specific effect of multicellular interfaces on tissue fusion remains largely unexplored. Here, a fa... | 1 Introduction Osteoarthritis is a prevalent and intensifying joint disorder, causing significant amount of pain, disability as well as socio‐economic costs worldwide. [ 1, 2, 3 ] Using novel tissue engineering and regenerative medicine (TERM) approaches, it was initially believed that implantation of MSCs, expanded au... |
10. 1002/advs. 202103332 | 2,022 | Advanced Science | ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo | Abstract To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate‐based tissue engineering (ALTEN), a biomimetic tissue platform that all... | 1 Introduction Tissue homeostasis depends on precise cell‐to‐cell communication and assimilation of cell contact, ECM, and paracrine signals. When perturbations are introduced through either small synthetic or biological molecules, each cell's response results from the integration of direct cell intrinsic effects of th... |
10. 1002/advs. 202103469 | 2,021 | Advanced Science | Biobridge: An Outlook on Translational Bioinks for 3D Bioprinting | Abstract 3D‐bioprinting (3DBP) possesses several elements necessary to overcome the deficiencies of conventional tissue engineering, such as defining tissue shape a priori, and serves as a bridge to clinical translation. This transformative potential of 3DBP hinges on the development of the next generation of bioinks t... | 1 Introduction 1. 1 Bioinks—the Present and Future Merriam‐Webster dictionary defines ink as “a colored material for writing and printing, ” where the attributes of the ink lie in the properties of the colloids. Drawing an analogy, in the broadest sense a bioink can be viewed as a medium to deposit biological informati... |
10. 1002/advs. 202103503 | 2,022 | Advanced Science | Light‐Triggered In Situ Biosynthesis of Artificial Melanin for Skin Protection | Abstract Tyrosinase‐mediated melanin synthesis is an essential biological process that can protect skin from UV radiation and radical species. This work reports on in situ biosynthesis of artificial melanin in native skin using photoactivatable tyrosinase (PaTy). The I41Y mutant of Streptomyces avermitilis tyrosinase (... | 1 Introduction Melanin is a polyphenol‐like biopolymer that shows useful biological activity, such as UV absorption, metal chelation, antioxidant, and radical scavenging properties. [ 1, 2, 3, 4 ] The primary function of melanin in the human body is to absorb UV radiation, thus protecting the human skin from photo‐agin... |
10. 1002/advs. 202103525 | 2,021 | Advanced Science | Directed Regeneration of Osteochondral Tissue by Hierarchical Assembly of Spatially Organized Composite Spheroids | Abstract The use of engineered scaffolds or stem cells is investigated widely in the repair of injured musculoskeletal tissue. However, the combined regeneration of hierarchical osteochondral tissue remains a challenge due to delamination between cartilage and subchondral bone or difficulty in spatial control over diff... | 1 Introduction Tissue engineering has achieved significant progress during the past few decades as a paradigm capable of reconstructing damaged organs, in particular, for potentially curing patients with osteochondral disorders. [ 1, 2 ] The osteochondral tissue is composed of cartilage and subchondral bone, which are ... |
10. 1002/advs. 202103526 | 2,022 | Advanced Science | Kidney Decellularized Extracellular Matrix Enhanced the Vascularization and Maturation of Human Kidney Organoids | Abstract Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive potential for disease modelling and regenerative medicine. However, the limited vascularization and immaturity of kidney organoids have been still remained to overcome. Extracellular matrix (ECM) can provide mechanical support an... | 1 Introduction Recent advances in stem cell biology have established several different protocols for generating kidney organoids from human pluripotent stem cells (hPSCs). The hPSC‐derived kidney organoids contain segmented structures with podocytes, proximal tubules, and distal tubules in nephron‐like arrangements. [ ... |
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