DOI stringlengths 13 47 | Year int64 2.01k 2.02k | Journal stringlengths 3 170 | Title stringlengths 1 281 ⌀ | Abstract stringlengths 14 62.9k ⌀ | Full Text stringlengths 22 5M |
|---|---|---|---|---|---|
10. 1002/admi. 201300085 | 2,014 | Advanced Materials Interfaces | Modulation of Biointeractions by Electrically Switchable Oligopeptide Surfaces: Structural Requirements and Mechanism | Understanding the dynamic behavior of switchable surfaces is of paramount importance for the development of controllable and tailor-made surface materials. Herein, electrically switchable mixed self-assembled monolayers based on oligopeptides have been investigated in order to elucidate their conformational mechanism a... | 1. Introduction Materials and surfaces with stimuli-responsive properties, which mimic biology, 1 are being developed experimentally for biomedical applications. 2 Active and switchable surfaces comprising domains that confer tailored responsiveness are playing an important part in the development of tissue engineering... |
10. 1002/admi. 201400026 | 2,014 | Advanced Materials Interfaces | Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus | No abstract available | Control and reversibility of biomolecular interactions at engineered interfaces presents opportunities to develop highly efficient substrates and devices for a wide range of biomedical applications. 1 – 4 A major challenge nowadays in the field of stimuli-responsive interfaces is to acquire a molecular understanding of... |
10. 1002/admt. 201900592 | 2,020 | Advanced materials technologies | Stereolithographic 3D Printing for Deterministic Control over Integration in Dual-Material Composites | This work introduces a rapid and facile approach to predictably control integration between two materials with divergent properties. Programmed integration between photopolymerizable soft and stiff hydrogels was investigated for their promise in applications such as tissue engineering where heterogeneous properties are... | No full text available |
10. 1002/admt. 202000683 | 2,021 | Advanced materials technologies | Microfluidic Printing of Tunable Hollow Microfibers for Vascular Tissue Engineering | Bioprinting of vascular tissues holds great potential in tissue engineering and regenerative medicine. However, challenges remain in fabricating biocompatible and versatile scaffolds for the rapid engineering of vascular tissues and vascularized organs. Here, we report novel bioink-enabled microfluidic printing of tuna... | No full text available |
10. 1002/admt. 202100551 | 2,021 | Advanced materials technologies | Biologically enhanced starch bio-ink for promoting 3D cell growth | The excellent rheological property has legitimated the suitability of starch hydrogel for extrusion-based 3D printing. However, the inability to promote cell attachment and migration has precluded the non-modified starch hydrogel from direct applications in the biomedical field. Herein, we develop a novel 3D printable ... | No full text available |
10. 1002/admt. 202101636 | 2,023 | Advanced materials technologies | Latest Advances in 3D Bioprinting of Cardiac Tissues | Cardiovascular diseases (CVDs) are known as the major cause of death worldwide. In spite of tremendous advancements in medical therapy, the gold standard for CVD treatment is still transplantation. Tissue engineering, on the other hand, has emerged as a pioneering field of study with promising results in tissue regener... | No full text available |
10. 1002/admt. 202101696 | 2,022 | Advanced Materials Technologies | Collagen‐Tannic Acid Spheroids for β‐Cell Encapsulation Fabricated Using a 3D Bioprinter | Abstract Type 1 Diabetes results from autoimmune response elicited against β‐cell antigens. Nowadays, insulin injections remain the leading therapeutic option. However, injection treatment fails to emulate the highly dynamic insulin release that β‐cells provide. 3D cell‐laden microspheres have been proposed during the ... | 1 Introduction Type 1 Diabetes Mellitus (T1DM) is an autoimmune disease characterized by an insulin deficiency caused by pancreatic β‐cell destruction, which leads to persistent high blood glucose levels. [ 1 ] Currently, a therapy based on daily exogenous insulin administration is the primary treatment for patients wi... |
10. 1002/admt. 202300026 | 2,023 | Advanced materials technologies | Spatial-Selective Volumetric 4D Printing and Single-Photon Grafting of Biomolecules within Centimeter-Scale Hydrogels via Tomographic Manufacturing | Conventional additive manufacturing and biofabrication techniques are unable to edit the chemicophysical properties of the printed object postprinting. Herein, a new approach is presented, leveraging light-based volumetric printing as a tool to spatially pattern any biomolecule of interest in custom-designed geometries... | 1 Introduction 3D printing technologies have rapidly become fundamental tools for biomedical research and personalized implant generation. These technologies have exceptional ability to generate biomaterial-based constructs with customized architecture and precise spatial patterning of different biocompatible materials... |
10. 1002/adom. 201800419 | 2,018 | Advanced Optical Materials | Additive Manufacturing: Applications and Directions in Photonics and Optoelectronics | Abstract The combination of materials with targeted optical properties and of complex, 3D architectures, which can be nowadays obtained by additive manufacturing, opens unprecedented opportunities for developing new integrated systems in photonics and optoelectronics. The recent progress in additive technologies for pr... | 1 Introduction Additive manufacturing (AM) is experiencing a rapid evolution in its relevant technologies, which are constantly shifting from object prototyping at small scale to much more comprehensive fabrication platforms. Currently available AM techniques encompass various methods, categorized in seven groups highl... |
10. 1002/adsu. 202000167 | 2,020 | Advanced sustainable systems | Strategies for Fabricating Protein Films for Biomaterials Applications | Proteins are naturally occurring functional building blocks that are useful for the fabrication of materials. Naturally-occurring proteins are biodegradable and most are biocompatible and non-toxic, making them attractive for the fabrication of biomaterials. Moreover, the fabrication of protein-based materials can be c... | No full text available |
10. 1002/adtp. 202000203 | 2,020 | Advanced Therapeutics | Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus | Abstract Systemic delivery of therapeutics for treatment of lung diseases has several limitations including poor organ distribution of delivered payload with relatively low accumulation of active substances in the lungs and severe adverse side effects. In contrast, nanocarrier based therapeutics provide a broad range o... | 1 Introduction Lung diseases are one of the main causes of death among both men and women worldwide. The mortality rates for lung diseases have been increasing by each year. [ 1, 2 ] Therefore, methods of developing new therapeutic solutions as well as improving the current therapies for the common lung diseases such a... |
10. 1002/advs. 201400010 | 2,015 | Advanced Science | Nanoparticle–Hydrogel Composites: Concept, Design, and Applications of These Promising, Multi‐Functional Materials | New technologies rely on the development of new materials, and these may simply be the innovative combination of known components. The structural combination of a polymer hydrogel network with a nanoparticle (metals, non‐metals, metal oxides, and polymeric moieties) holds the promise of providing superior functionality... | 1 Introduction Wichterlie and Lim 1 reported the first synthetic hydrogels with control of properties such as swelling and shrinking over several orders of magnitude. This initial discovery provided the foundation for stimuli‐responsive systems. The cross‐linked polymer network was highly sensitivity to stimuli such as... |
10. 1002/advs. 201500026 | 2,015 | Advanced Science | Virus Nanoparticles Mediated Osteogenic Differentiation of Bone Derived Mesenchymal Stem Cells | There are few methodologies that allow manipulating a biomaterial surface at nanometer scale, which controllably influence different cellular functions. In this study, virus nanoparticles with different structural features are selected to prepare 2D substrates with defined nanoscale topographies and the cellular respon... | 1 Introduction It is well established that cell–material interactions regulate numerous cellular functions. 1 Biological processes such as adhesion, growth, differentiation, and apoptosis, are controlled by cell shape and cytoskeletal organization which is directed by cell–surface interactions. 2 Meanwhile, the surface... |
10. 1002/advs. 201500069 | 2,015 | Advanced Science | Multifunctional Hydrogels with Reversible 3D Ordered Macroporous Structures | Three‐dimensionally ordered macroporous (3DOM) hydrogels prepared by colloidal crystals templating display highly reversible shape memory properties, as confirmed by indirect electron microscopy imaging of their inverse replicas and direct nanoscale resolution X‐ray microscopy imaging of the hydrated hydrogels. Modific... | Hydrogels are synthetic or natural polymer networks crosslinked either chemically or physically to maintain 3D structures that are able to absorb and retain large amounts of water. 1 Porous biocompatible hydrogels combine porosity with biocompatibility and play an important role in various biomedical applications, such... |
10. 1002/advs. 201500082 | 2,015 | Advanced Science | Multistimuli Sensitive Behavior of Novel Bodipy‐Involved Pillararene‐Based Fluorescent Rotaxane and Its Supramolecular Gel | Fluorescent rotaxane BC12P5 is successfully constructed with 1, 4‐diethoxypillararene as wheel over a long alkyl axle with Bodipy chromophore as one stopper for the first time. NMR spectra clearly reveal its molecular shuttle nature triggered by multiple external stimuli including solvent polarity and temperature. In p... | 1 Introduction This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Inspired by naturally occurring biological motors such as the ATPase rotary motor and the kinesin or my... |
10. 1002/advs. 201500118 | 2,015 | Advanced Science | Rational Design of Materials Interface for Efficient Capture of Circulating Tumor Cells | Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and biochemical properties o... | 1 Introduction Metastasis, the spread of tumor cells from the primary tumor site to vital distant organs through the circulatory system, is directly responsible for most carcinoma‐related deaths in cancer patients. 1, 2, 3 Understanding the metastasis process and investigating the cause of metastasis will benefit the d... |
10. 1002/advs. 201500122 | 2,015 | Advanced Science | Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction | Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombos... | 1 Introduction Heart diseases are among the major causes of death worldwide. The main difficulties in the treatment of cardiac injuries arise from the limited capability of cardiac tissue to regenerate itself, i. e. , the irreversibility of cardiac damages, the inability of cardiac tissues to tolerate ischemia, and the... |
10. 1002/advs. 201500125 | 2,015 | Advanced Science | Simple 3D Printed Scaffold‐Removal Method for the Fabrication of Intricate Microfluidic Devices | An easy and cheap fabrication method for intricate polydimethylsiloxane microfluidic devices is presented. The acrylonitrile butadiene styrene scaffold‐removal method uses cheap, off‐the‐shelf materials and equipment for the fabrication of intricate microfluidic devices. The versatility of the method is proven by the f... | Microfluidics 1, 2 is a continuously growing field, of great interest in chemistry, 3 physics, 4, 5 drug discovery, 6 biology, 7, 8 chemical biology, 9 biomedical research, 10 tissue engineering, 11 and most recently, organs‐on‐chip. 12 The small amounts of liquid required for experiments, the physics of fluids at the ... |
10. 1002/advs. 201500149 | 2,015 | Advanced Science | High‐Throughput Contact Flow Lithography | High‐throughput fabrication of graphically encoded hydrogel microparticles is achieved by combining flow contact lithography in a multichannel microfluidic device and a high capacity 25 mm LED UV source. Production rates of chemically homogeneous particles are improved by two orders of magnitude. Additionally, the cust... | Recent advances in fabrication techniques have created new opportunities for applications of polymer particles, beyond spherical particles. 1 Anisotropic polymer particles with precise shapes or heterogeneous chemistries, in particular anisotropic hydrogel particles, have demonstrated unique advantages in numerous fiel... |
10. 1002/advs. 201500393 | 2,016 | Advanced Science | Sustained Delivery Growth Factors with Polyethyleneimine‐Modified Nanoparticles Promote Embryonic Stem Cells Differentiation and Liver Regeneration | Stem‐cell‐derived hepatocyte transplantation is considered as a potential method for the therapy of acute and chronic liver failure. However, the low efficiency of differentiation into mature and functional hepatocytes remains a major challenge for clinical applications. By using polyethyleneimine‐modified silica nanop... | 1 Introduction This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Hepatic failure including cirrhosis and fibrosis is a serious threat to human health, and recently embr... |
10. 1002/advs. 201500413 | 2,016 | Advanced Science | Two‐Dimensional Fluorinated Graphene: Synthesis, Structures, Properties and Applications | Fluorinated graphene, an up‐rising member of the graphene family, combines a two‐dimensional layer‐structure, a wide bandgap, and high stability and attracts significant attention because of its unique nanostructure and carbon–fluorine bonds. Here, we give an extensive review of recent progress on synthetic methods and... | 1 Introduction Since Andre Geim and Kostya Novoselov first isolated high‐quality few‐atom‐thick nanosheets (including single‐layer) from graphite, the ability to prepare graphene and its derivatives have triggered intense research in two‐dimensional nanomaterials all over the world. 1 Subsequently, graphene‐based mater... |
10. 1002/advs. 201600058 | 2,016 | Advanced Science | Biologically Inspired Smart Release System Based on 3D Bioprinted Perfused Scaffold for Vascularized Tissue Regeneration | A critical challenge to the development of large‐scale artificial tissue grafts for defect reconstruction is vascularization of the tissue construct. As an emerging tissue/organ manufacturing technique, 3D bioprinting offers great precision in controlling the internal architecture of a scaffold with preferable mechanic... | 1 Introduction Vascularization of large‐scale artificial bone tissue grafts is the most critical challenge for various large bone defect reconstruction. Traditional tissue engineering has been focusing on combining osteoconductive scaffolds, osteoinductive growth factors, and osteogenic precursor cells to repair and re... |
10. 1002/advs. 201600160 | 2,016 | Advanced Science | In Vivo Long‐Term Biodistribution, Excretion, and Toxicology of PEGylated Transition‐Metal Dichalcogenides MS | With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of diffe... | 1 Introduction In the past few years, 2D nanomaterials have received tremendous attention and been applied in various fields due to their fantastic physical and chemical properties. 1, 2, 3, 4, 5, 6, 7, 8 As an analogue of 2D graphene, transition metal dichalcogenides (TMDCs), generally described as the formula MX 2, i... |
10. 1002/advs. 201600285 | 2,017 | Advanced Science | Self‐Assembled Bifunctional Peptide as Effective Drug Delivery Vector with Powerful Antitumor Activity | E‐cadherin/catenin complex is crucial for cancer cell migration and invasion. The histidine‐alanine‐valine (HAV) sequence has been shown to inhibit a variety of cadherin‐based functions. In this study, by fusing HAV and the classical tumor‐targeting Arg‐Gly‐Asp (RGD) motif and Asn‐Gly‐Arg (NGR) motif to the apoptosis‐i... | 1 Introduction Lung cancer is the leading cause of cancer death among males in many parts of the world, and in more developed countries, it has surpassed breast cancer among females. 1, 2 Advanced non‐small‐cell lung cancer (NSCLC) is responsible for most of the death. Docetaxel (DOC), erlotinib, and pemetrexed are the... |
10. 1002/advs. 201600410 | 2,017 | Advanced Science | Bioinspired Mechano‐Sensitive Macroporous Ceramic Sponge for Logical Drug and Cell Delivery | On‐demand, ultrahigh precision delivery of molecules and cells assisted by scaffold is a pivotal theme in the field of controlled release, but it remains extremely challenging for ceramic‐based macroporous scaffolds that are prevalently used in regenerative medicine. Sea sponges (Phylum Porifera), whose bodies possess ... | On‐demand delivery of molecules and cells is a pivotal theme in the field of controlled release. While most on‐demand delivery systems developed so far have placed much emphasis on achieving the release of cargos at controllable rates or by various release gates, some recently reported systems have achieved ultrahigh p... |
10. 1002/advs. 201600480 | 2,017 | Advanced Science | Draw‐Spinning of Kilometer‐Long and Highly Stretchable Polymer Submicrometer Fibers | A new method is developed to directly spinning perfectly uniaxial fibers in an ultrafast manner. Besides, this method can tune the fibers' diameter through adjusting processing parameters such as the feeding rate of precursors. Uniaxial nylon 66 fibers prepared via this method show superior mechanical properties due to... | In this study, we report draw‐spinning method that can produce aligned polymer ultrathin fibers with diameter down to 200 nm. Apart from creating perfectly aligned fibers, this method can draw fibers at a high speed and can thus reorient molecular chains. Tensile tests show that nylon 66 fiber bundles fabricated by dra... |
10. 1002/advs. 201700029 | 2,017 | Advanced Science | Recent Progress on Piezoelectric and Triboelectric Energy Harvesters in Biomedical Systems | Implantable medical devices (IMDs) have become indispensable medical tools for improving the quality of life and prolonging the patient's lifespan. The minimization and extension of lifetime are main challenges for the development of IMDs. Current innovative research on this topic is focused on internal charging using ... | 1 Introduction Over last decades, implantable medical devices (IMDs) have experienced tremendous growth, becoming indispensable medical tools for improving the quality of life and prolonging the patient's lifespan. Currently, the IMDs have been implanted in various parts of human body as artificial treatments and diagn... |
10. 1002/advs. 201700191 | 2,017 | Advanced Science | Precise Protein Photolithography (P | Precise patterning of biomaterials has widespread applications, including drug release, degradable implants, tissue engineering, and regenerative medicine. Patterning of protein‐based microstructures using UV‐photolithography has been demonstrated using protein as the resist material. The Achilles heel of existing prot... | 1 Introduction Precise patterning of micro and nanostructures using polymer‐based biomaterials has widespread applications including drug release, degradable implants, tissue engineering, and regenerative medicine. 1, 2, 3, 4 In this context, natural silk proteins obtained from cocoons of the silkworm Bombyx mori provi... |
10. 1002/advs. 201700278 | 2,017 | Advanced Science | Netrin‐1 Promotes Inflammation Resolution to Achieve Endothelialization of Small‐Diameter Tissue Engineering Blood Vessels by Improving Endothelial Progenitor Cells Function In Situ | Abstract The transplant of small‐diameter tissue engineering blood vessels (small‐diameter TEBVs) (<6 mm) in vascular replacement therapy often fails because of early onset thrombosis and long‐standing chronic inflammation. The specific inflammation state involved in small‐diameter TEBVs transplants remains unclear, an... | 1 Introduction Cardiovascular disease is a leading cause of death that creates a significant burden on patients and requires replacement therapy to treat the damaged vessels. Small‐diameter tissue engineering blood vessels (TEBVs) have been used with increasing frequency for vascular replacement therapy, and the constr... |
10. 1002/advs. 201700310 | 2,017 | Advanced Science | Sequentially Programmable and Cellularly Selective Assembly of Fluorescent Polymerized Vesicles for Monitoring Cell Apoptosis | Abstract The introduction of controlled self‐assembly into living organisms opens up desired biomedical applications in wide areas including bioimaging/assays, drug delivery, and tissue engineering. Besides the enzyme‐activated examples reported before, controlled self‐assembly under integrated stimuli, especially in t... | 1 Introduction Construction of self‐assembled nanomaterials aiming to biomedical applications is attractive ever‐growing interests, including various biosensing/imaging probes, drug delivery systems, tissue engineering materials for the purpose of diagnosis and therapy. 1, 2, 3, 4, 5 On demand of precise medicine with ... |
10. 1002/advs. 201700401 | 2,017 | Advanced Science | 3D Printing of Lotus Root‐Like Biomimetic Materials for Cell Delivery and Tissue Regeneration | Abstract Biomimetic materials have drawn more and more attention in recent years. Regeneration of large bone defects is still a major clinical challenge. In addition, vascularization plays an important role in the process of large bone regeneration and microchannel structure can induce endothelial cells to form rudimen... | 1 Introduction With natural evolution for millions of years, organisms have achieved multifunctional and sophisticated structures, textures or patterns spontaneously for survival, of which the unparalleled advantages have inspired the biomimetic synthesis of materials and structures in recent years. By imitating the sp... |
10. 1002/advs. 201700402 | 2,018 | Advanced Science | A Modular Strategy to Engineer Complex Tissues and Organs | Abstract Currently, there are no synthetic or biologic materials suitable for long‐term treatment of large tracheal defects. A successful tracheal replacement must (1) have radial rigidity to prevent airway collapse during respiration, (2) contain an immunoprotective respiratory epithelium, and (3) integrate with the h... | 1 Introduction Patients suffering from tracheal stenosis have a significantly reduced quality of life. The diseased region of the trachea cannot be resected when more than half of the airway is affected in adults. 1 Thus, tracheal tissue engineering has the exciting potential to fill this gap and will have a tremendous... |
10. 1002/advs. 201700499 | 2,018 | Advanced Science | 3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis | Abstract Treating peripheral nerve injury faces major challenges and may benefit from bioactive scaffolds due to the limited autograft resources. Graphene oxide (GO) has emerged as a promising nanomaterial with excellent physical and chemical properties. GO has functional groups that confer biocompatibility that is bet... | 1 Introduction Although peripheral nerves exhibit some self‐healing potential after mild and moderate trauma as they spontaneously start new axons sprouting after injury, 1 successful reinnervation cannot be achieved, especially for long‐range nerve defects and it calls for implantation of a nerve graft to bridge the g... |
10. 1002/advs. 201700513 | 2,018 | Advanced Science | Polysaccharide‐Based Controlled Release Systems for Therapeutics Delivery and Tissue Engineering: From Bench to Bedside | Abstract Polysaccharides or polymeric carbohydrate molecules are long chains of monosaccharides that are linked by glycosidic bonds. The naturally based structural materials are widely applied in biomedical applications. This article covers four different types of polysaccharides (i. e. , alginate, chitosan, hyaluronic... | 1 Introduction The clinical efficacy of low‐molecular‐weight chemotherapeutics and functional biological macromolecules (i. e. , proteins and oligonucleotides) is often limited by a number of obstacles, including unfavorable solubility, loss of bioactive structure prior to reaching the disease lesion site, inadequate c... |
10. 1002/advs. 201700527 | 2,018 | Advanced Science | Antibacterial Hydrogels | Abstract Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical researc... | 1 Introduction Since the first discovery of penicillin in 1928, 1 antibiotics have been widely used in the antibacterial field. With the development of public hygiene and biomedical technology, many infections have been effectively suppressed or even conquered, and the quality of life for human beings has been signific... |
10. 1002/advs. 201700550 | 2,017 | Advanced Science | 3D‐Bioprinted Osteoblast‐Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo | Abstract An osteoblast‐laden nanocomposite hydrogel construct, based on polyethylene glycol diacrylate (PEGDA)/laponite XLG nanoclay ([Mg 5. 34 Li 0. 66 Si 8 O 20 (OH) 4 ]Na 0. 66, clay )/hyaluronic acid sodium salt (HA) bio‐inks, is developed by a two‐channel 3D bioprinting method. The novel biodegradable bio‐ink A, c... | 1 Introduction Traditional strategies for bone tissue engineering are based on the facilitation of cell growth into engineered interconnecting scaffolds to generate a functional tissue construct for the reestablishment of structure and function in damaged bone tissues. 1 However, the realization of the desired levels o... |
10. 1002/advs. 201700666 | 2,018 | Advanced Science | Engineering a Tumor Microenvironment‐Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells | Abstract The insufficient number of cells suitable for transplantation is a long‐standing problem to cell‐based therapies aimed at tissue regeneration. Xenogeneic cancer cells (XCC) may be an alternative source of therapeutic cells, but their transplantation risks both immune rejection and unwanted spreading. In this s... | 1 Introduction Cell transplantation aimed at tissue reconstruction and regeneration holds promise to solve the fundamental challenges with organ transplantation, including an extreme shortage of whole organs suitable for medical implantation as well as its associated medical, social, and ethical issues. 1, 2, 3 Ideally... |
10. 1002/advs. 201700678 | 2,017 | Advanced Science | Valence State Manipulation of Cerium Oxide Nanoparticles on a Titanium Surface for Modulating Cell Fate and Bone Formation | Abstract Understanding cell–biomaterial interactions is critical for the control of cell fate for tissue engineering and regenerative medicine. Here, cerium oxide nanoparticles (CeONPs) are applied at different Ce 4+ /Ce 3+ ratios (i. e. , 0. 46, 1. 23, and 3. 23) to titanium substrate surfaces by magnetron sputtering ... | 1 Introduction Understanding the interactions between stem cells and biomaterials surface is essential for controlling stem cell fates, including adhesion, proliferation, and osteogenic differentiation, in bone tissue engineering and regenerative medicine. 1 Tremendous advancements have been made in tailoring bone biom... |
10. 1002/advs. 201700817 | 2,018 | Advanced Science | A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair | Abstract Polyetheretherketone (PEEK)/β‐tricalcium phosphate (β‐TCP) scaffolds are expected to be able to combine the excellent mechanical strength of PEEK and the good bioactivity and biodegradability of β‐TCP. While PEEK acts as a closed membrane in which β‐TCP is completely wrapped after the melting/solidifying proce... | 1 Introduction Polyetheretherketone (PEEK) is a promising biopolymer, as its mechanical strength and elastic modulus are close to those of human cortical bone. 1 β‐tricalcium phosphate (β‐TCP), a bioceramic material, has good bioactivity as well as biodegradability. 2 The binary scaffold composed of PEEK and β‐TCP may ... |
10. 1002/advs. 201700931 | 2,018 | Advanced Science | Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future | Abstract At the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend directly within organs and tissues. These sophisticated devices are mediators, recorders, and ... | A Pathway toward a Cybernetic Future Journal: Advanced Science Publish Date: 2018 Abstract: Abstract At the crossroads of chemistry, electronics, mechanical engineering, polymer science, biology, tissue engineering, computer science, and materials science, electrical devices are currently being engineered that blend di... |
10. 1002/advs. 201800006 | 2,018 | Advanced Science | Histone Deacetylase 7‐Derived Peptides Play a Vital Role in Vascular Repair and Regeneration | Abstract Cardiovascular disease is a leading cause of morbidity and mortality globally. Accumulating evidence indicates that local resident stem/progenitor cells play an important role in vascular regeneration. Recently, it is demonstrated that a histone deacetylase 7‐derived 7‐amino acid peptide (7A, MHSPGAD) is criti... | 1 Introduction Cardiovascular disease (CVD) represents a major cause of morbidity and mortality globally. Intimal injury is a common pathological basis of the process of CVD, and the recovery of injured endothelium is essential for protection against CVD. 1, 2 Dysfunction of endothelial cells (ECs) is thought to play a... |
10. 1002/advs. 201800252 | 2,018 | Advanced Science | DIY 3D Microparticle Generation from Next Generation Optofluidic Fabrication | Abstract Complex‐shaped microparticles can enhance applications in drug delivery, tissue engineering, and structural materials, although techniques to fabricate these particles remain limited. A microfluidics‐based process called optofluidic fabrication that utilizes inertial flows and ultraviolet polymerization has sh... | Engineered microparticles with nonspherical shapes have attracted increased attention recently due to different shape‐dependent functionalities that emerge from specific particle geometries. 1 Examples of these shape‐dependent functionalities are seen in biology where the shape and surface area of drug carrier particle... |
10. 1002/advs. 201800261 | 2,018 | Advanced Science | A Modular Assembly of Spinal Cord–Like Tissue Allows Targeted Tissue Repair in the Transected Spinal Cord | Abstract Tissue engineering–based neural construction holds promise in providing organoids with defined differentiation and therapeutic potentials. Here, a bioengineered transplantable spinal cord–like tissue (SCLT) is assembled in vitro by simulating the white matter and gray matter composition of the spinal cord usin... | 1 Introduction Spinal cord injury (SCI) causes massive death of neurons and glia, leaving a hostile microenvironment that impedes nerve fiber regeneration and tissue repair. 1 Although endogenous neural stem cells (NSCs) have the potential for spinal repair, their bias toward astrocytic differentiation hinders the rest... |
10. 1002/advs. 201800361 | 2,018 | Advanced Science | Nanoscale Coatings for Ultralow Dose BMP‐2‐Driven Regeneration of Critical‐Sized Bone Defects | Abstract While new biomaterials for regenerative therapies are being reported in the literature, clinical translation is slow. Some existing regenerative approaches rely on high doses of growth factors, such as bone morphogenetic protein‐2 (BMP‐2) in bone regeneration, which can cause serious side effects. An ultralow‐... | 1 Introduction Active lifestyles in the young, obesity, diabetes, and osteoporosis in the elderly are driving an increase in the occurrence of traumatic injury. In 2010, >250 000 people in the USA over the age of 65 were hospitalized for hip fractures, 1 with an increasing number of patients experiencing nonhealing (kn... |
10. 1002/advs. 201800448 | 2,018 | Advanced Science | Recent Advances in Engineering the Stem Cell Microniche in 3D | Abstract Conventional 2D cell culture techniques have provided fundamental insights into key biochemical and biophysical mechanisms responsible for various cellular behaviors, such as cell adhesion, spreading, division, proliferation, and differentiation. However, 2D culture in vitro does not fully capture the physical... | 1 Introduction In vivo, stem cells reside in a complex, specialized, and dynamic microenvironment, or “microniche. ” 1 Although these microenvironments are extremely diverse, they share a number of characteristic features of function and composition. 2 The microenvironment serves as a structural support for cells, but ... |
10. 1002/advs. 201800450 | 2,018 | Advanced Science | Stretchable Multiresponsive Hydrogel with Actuatable, Shape Memory, and Self‐Healing Properties | Abstract Smart hydrogels with responsive behaviors have attracted tremendous attention. However, it is still a challenge to synthesize stretchable hydrogels capable of changing their original properties in response to multiple external stimuli. Here, integration of actuation function, shape memory, and self‐healing cap... | Functional materials, like actuation hydrogel, 1 shape memory, 2 and self‐healing polymers, 3 have drawn increasing attentions and perform extensive applications in fields of tissue engineering, 4 drug delivery, 5 smart coating, 6 and soft robotics. 7 Up to now, efforts devoted to the development of functional material... |
10. 1002/advs. 201800471 | 2,018 | Advanced Science | Elucidating Self‐Assembling Peptide Aggregation via Morphoscanner: A New Tool for Protein‐Peptide Structural Characterization | Abstract Self‐assembling and molecular folding are ubiquitous in Nature: they drive the organization of systems ranging from living creatures to DNA molecules. Elucidating the complex dynamics underlying these phenomena is of crucial importance. However, a tool for the analysis of the various phenomena involved in prot... | 1 Introduction The spontaneous organization of initially chaotic biological systems has helped scientists to explore the origins of Life on Earth. 1, 2, 3, 4, 5 Indeed, it is widely accepted that the self‐assembling propensity of DNA, RNA, proteins, and peptides is one of the main molecular mechanisms that may have spa... |
10. 1002/advs. 201800506 | 2,018 | Advanced Science | Oscillatory Strain Promotes Vessel Stabilization and Alignment through Fibroblast YAP‐Mediated Mechanosensitivity | Abstract Endothelial cells form the interior layer of blood vessels and, as such, are constantly exposed to shear stress and mechanical strain. While the impact of shear stress on angiogenesis is widely studied, the role of mechanical strain is less understood. To this end, endothelial cells and fibroblasts are cocultu... | 1 Introduction During vascularization, endothelial cells (ECs) sense two forms of mechanical stimulation, shear stress, as a consequence of blood flow, and mechanical strain, as a consequence of rhythmic heart beating and tissue contraction. 1, 2, 3, 4 While many studies have focused on the effect of shear stress on ve... |
10. 1002/advs. 201800518 | 2,018 | Advanced Science | Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead | Abstract Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because of their unique planar structure and prominent physiochemical properties. Generally, ceramic‐based biomaterials, fabricated by high‐temperature solid‐phase reactions, are preferred as bone scaf... | 1 Introduction The rapid progress of clinic biomedicine and nanobiotechnology has stimulated the generation of diverse novel inorganic nanosystems, which offers multiple theranostic modalities as potential alternatives in combating various diseases by synergistic therapy and multimodal imaging, especially in cancer the... |
10. 1002/advs. 201800560 | 2,018 | Advanced Science | Enhanced Raman Investigation of Cell Membrane and Intracellular Compounds by 3D Plasmonic Nanoelectrode Arrays | Abstract 3D nanostructures are widely exploited in cell cultures for many purposes such as controlled drug delivery, transfection, intracellular sampling, and electrical recording. However, little is known about the interaction of the cells with these substrates, and even less about the effects of electroporation on th... | 1 Introduction The cellular membrane is an extremely complex and dynamic environment that represents the gateway for all cell reactions and exchanges with the surrounding biological environment. Nutrients as well as molecules that drive the interactions with other cells and tissues pass through the plasma membrane. The... |
10. 1002/advs. 201800638 | 2,018 | Advanced Science | Adaptable Fast Relaxing Boronate‐Based Hydrogels for Probing Cell–Matrix Interactions | Abstract Hydrogels with tunable viscoelasticity hold promise as materials that can recapitulate many dynamic mechanical properties found in native tissues. Here, covalent adaptable boronate bonds are exploited to prepare hydrogels that exhibit fast relaxation, with relaxation time constants on the order of seconds or l... | Hydrogels have been widely used as matrices to culture and grow primary cells in 3D with applications in tissue engineering and regenerative medicine. 1 By incorporating various biochemical, biophysical, and mechanical cues into a single system, hydrogels provide a powerful in vitro model to probe and understand the fu... |
10. 1002/advs. 201800776 | 2,018 | Advanced Science | Silicon‐Enhanced Adipogenesis and Angiogenesis for Vascularized Adipose Tissue Engineering | Abstract The enhancement of adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and sufficient vascularization remain great challenges for the successful reconstruction of engineered adipose tissue. Here, the bioactive effects of silicon (Si) ions on adipogenic differentiation of human BMSCs (HBMSC... | 1 Introduction Adipose tissue engineering strategies have shown great potential in the treatment of soft tissue defects originated from severe burns, trauma, tumor resection, and congenital deformities. 1 Bone marrow mesenchymal stem cells (BMSCs) are a promising cell type for tissue engineering due to their strong pro... |
10. 1002/advs. 201800808 | 2,019 | Advanced Science | Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration | Abstract MicroRNAs effectively modulate protein expression and cellular response. Unfortunately, the lack of robust nonviral delivery platforms has limited the therapeutic application of microRNAs. Additionally, there is a shortage of drug‐screening platforms that are directly translatable from in vitro to in vivo. Her... | 1 Introduction MicroRNAs (miRs) are short noncoding RNAs that effectively regulate protein translation by enabling mRNA degradation and/or repressing protein translation. 1, 2 This process plays significant roles in modulating protein expression by RNA interference (RNAi). Correspondingly, miRs have been recognized as ... |
10. 1002/advs. 201801037 | 2,018 | Advanced Science | Bio‐Inspired Micropatterned Platforms Recapitulate 3D Physiological Morphologies of Bone and Dentinal Cells | Abstract Cells exhibit distinct 3D morphologies in vivo, and recapitulation of physiological cell morphologies in vitro is pivotal not only to elucidate many fundamental biological questions, but also to develop new approaches for tissue regeneration and drug screening. However, conventional cell culture methods in eit... | Cells in the body reside in a distinct 3D microenvironment – highly structured extracellular matrix (ECM) that is a nanofibrous network and possesses well‐organized hierarchic architecture ranged from nano to macro scales. When cells are removed from the in vivo microenvironment and are cultured on an artificial matrix... |
10. 1002/advs. 201801039 | 2,018 | Advanced Science | Engineering Precision Medicine | Abstract Advances in genomic sequencing and bioinformatics have led to the prospect of precision medicine where therapeutics can be advised by the genetic background of individuals. For example, mapping cancer genomics has revealed numerous genes that affect the therapeutic outcome of a drug. Through materials and cell... | 1 Introduction Each person responds differently to certain drugs. When prescribed with ineffective drugs, the patients may not only pay for the financial cost, but also suffer from the physiological side effects that could be catastrophic in certain circumstances. 1 This calls for the tailoring of therapies to fit each... |
10. 1002/advs. 201801175 | 2,018 | Advanced Science | Exogenous Physical Irradiation on Titania Semiconductors: Materials Chemistry and Tumor‐Specific Nanomedicine | Abstract Titania semiconductors can be activated by external physical triggers to produce electrons (e − ) and holes (h + ) pairs from the energy‐band structure and subsequently induce the generation of reactive oxygen species for killing cancer cells, but the traditional ultraviolet light with potential phototoxicity ... | 1 Introduction As one of the mostly explored multidisciplinary research frontiers, nanomedicine has attracted the broad attention of scientific community ranging from material science, chemistry, pharmacy, biology, and biomedicine. 1, 2, 3, 4, 5, 6 It has shown the intriguing performance and application prospect in mol... |
10. 1002/advs. 201801260 | 2,018 | Advanced Science | Ion Therapy: A Novel Strategy for Acute Myocardial Infarction | Abstract Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling,... | 1 Introduction Eliminating vascular obstruction and promoting angiogenesis can reduce myocardial apoptosis and necrosis, which is critical in the treatment of acute myocardial infarction (AMI). 1 Despite the most advanced pharmacological and medical device treatment methods were used, neither of these promote cardiac a... |
10. 1002/advs. 201801290 | 2,018 | Advanced Science | Matrix Rigidity‐Dependent Regulation of Ca | Abstract The dynamic regulation of signal transduction at plasma membrane microdomains remains poorly understood due to limitations in current experimental approaches. Genetically encoded biosensors based on fluorescent resonance energy transfer (FRET) can provide high spatiotemporal resolution for imaging cell signali... | 1 Introduction Cell‐based therapeutics are revolutionizing the medicine field. 1 One promising branch is stem cell‐based therapy, which has developed from preclinical to early clinical studies for treatment of various diseases. 2 Human mesenchymal stem cells (hMSCs) are a type of adult stem cells (ASCs) that are multip... |
10. 1002/advs. 201801452 | 2,018 | Advanced Science | In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells | Abstract The preparation and characterization of a porous hybrid cryogel based on the two organic polymers, poly(vinyl alcohol) (PVA) and karaya gum (KG), into which polyphosphate (polyP) nanoparticles have been incorporated, are described. The PVA/KG cryogel is prepared by intermolecular cross‐linking of PVA via freez... | 1 Introduction Advanced tissue engineering, as a branch of regenerative medicine, focuses on the replacement/regeneration of impaired/damaged tissues and organs to restore their biophysiological function within an organism. In the beginning of the last century, Alexis Carrel and Charles Lindbergh succeeded to keep enti... |
10. 1002/advs. 201801555 | 2,018 | Advanced Science | Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration | Abstract The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing–promoting properties that match the dynamic healing process of skin flap reg... | Hydrogels are biomaterials widely used for tissue repair in tissue engineering. With their biocompatibility and tunable architecture, hydrogels can simulate the physical structure of the extracellular matrix to promote cell proliferation and tissue regeneration. 1, 2, 3 Hydrogels are able to encapsulate and deliver dif... |
10. 1002/advs. 201801664 | 2,019 | Advanced Science | Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering? | Abstract Given their durability and long‐term stability, self‐healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self‐healing remain... | 1 Introduction In recent years, tissue engineering has emerged as a promising technology to grow organs from scratch, 1, 2, 3 replicate biological mechanisms of various diseases, 4, 5, 6, 7 address tissue‐related ailments 8, 9, 10, 11, 12 and enable life extension in the growing aging population. 13, 14 So far, most of... |
10. 1002/advs. 201802033 | 2,019 | Advanced Science | On‐Demand Coalescence and Splitting of Liquid Marbles and Their Bioapplications | Abstract Coalescence and splitting of liquid marbles (LMs) are critical for the mixture of precise amount precursors and removal of the wastes in the microliter range. Here, the coalescence and splitting of LMs are realized by a simple gravity‐driven impact method and the two processes are systematically investigated t... | 1 Introduction Liquid marbles (LMs) are mainly composed of liquid droplets that are encapsulated and stabilized by solid micro or nanoscale lyophobic particles at the spherical liquid–air interface. 1 They show extreme mobility, elasticity, and stability on both hydrophilic and hydrophobic surfaces. LM has attracted in... |
10. 1002/advs. 201802045 | 2,019 | Advanced Science | Bioinspired Preservation of Natural Killer Cells for Cancer Immunotherapy | Abstract The ability to cryopreserve natural killer (NK) cells has a significant potential in modern cancer immunotherapy. Current cryopreservation protocols cause deterioration in NK cell viability and functionality. This work reports the preservation of human cytokine‐activated NK cell viability and function followin... | Natural killer (NK) cells represent our body's first line of defense against cancers. 1, 2, 3 These cells play a key role in innate immune system, and have a unique ability to fight cancer cells without prior sensitization (unlike T and B‐ lymphocytes). 4, 5 Recently, various cell lines (e. g. , NK‐92, NK‐YS, and KHYG‐... |
10. 1002/advs. 201802077 | 2,019 | Advanced Science | Cytocompatible, Injectable, and Electroconductive Soft Adhesives with Hybrid Covalent/Noncovalent Dynamic Network | Abstract Synthetic conductive biopolymers have gained increasing interest in tissue engineering, as they can provide a chemically defined electroconductive and biomimetic microenvironment for cells. In addition to low cytotoxicity and high biocompatibility, injectability and adhesiveness are important for many biomedic... | 1 Introduction Hydrogels have drawn a lot of attention as promising extracellular matrix (ECM) mimicking biological materials. Various characteristics, such as swelling degree, water content, stiffness, porosity, viscoelastic properties, and biocompatibility can be tailored for different applications. 1, 2, 3 The incor... |
10. 1002/advs. 201802112 | 2,019 | Advanced Science | A Reversibly Responsive Fluorochromic Hydrogel Based on Lanthanide–Mannose Complex | Abstract Fluorochromic materials that are dynamic in response to external stimuli are of great interest for the development of advanced sensors and luminescent materials. Herein, a design based on a lanthanide‐containing polymeric hydrogel possessing characteristic emission of lanthanides (Eu and Tb) and showing respon... | 1 Introduction Adaptive optical materials that can adapt or actuate in response to external stimuli such as light, temperature, pH, metal ions, mechanical stress, and chemical stress are critical to the development of smart material systems. 1 In recent years, there are profound interests to develop new fluorochromic m... |
10. 1002/advs. 201802342 | 2,019 | Advanced Science | Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach | Abstract Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro‐ and nanosc... | Multicompartmental microparticles (MCMs) are under investigation for applications such as multidrug delivery systems, 1 in cell culturing technologies, 2 for multienzyme tandem reactions, 3 as micromotors, [[qv: 1f, 4]] for multitarget detection, 5 as multifunctional encoded materials, 6 etc. 7 The full potential of MC... |
10. 1002/advs. 201870020 | 2,018 | Advanced Science | Tissue Engineering: 3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis (Adv. Sci. 4/2018) | In this article number https://doi. org/10. 1002/advs. 201700499, Yuanming Ouyang, Weien Yuan, Cunyi Fan, and co‐workers present 3D integration molding of a graphene oxide/polycaprolactone nanoscaffold. The nanoscaffold has high electrical conductivity, has excellent biocompatibility with multiple pores for free exchan... | No full text available |
10. 1002/advs. 201900043 | 2,019 | Advanced Science | DNA Nanotechnology Enters Cell Membranes | Abstract DNA is more than a carrier of genetic information: It is a highly versatile structural motif for the assembly of nanostructures, giving rise to a wide range of functionalities. In this regard, the structure programmability is the main advantage of DNA over peptides, proteins, and small molecules. DNA amphiphil... | 1 Introduction Embedded in a unique language, deoxyribonucleic acid (DNA) carries the lion's share of the hereditary information in living cells. Ever since Friedrich Miescher isolated DNA in 1869, 1 the scientific community extensively investigated its properties and possible applications. James Watson and Francis Cri... |
10. 1002/advs. 201900099 | 2,019 | Advanced Science | Intensified Stiffness and Photodynamic Provocation in a Collagen‐Based Composite Hydrogel Drive Chondrogenesis | Abstract Directed differentiation of bone‐marrow‐derived stem cells (BMSCs) toward chondrogenesis has served as a predominant method for cartilage repair but suffers from poor oriented differentiation tendency and low differentiation efficiency. To overcome these two obstacles, an injectable composite hydrogel that con... | 1 Introduction In regenerative medicine, cartilage repair remains a challenging task, because articular cartilage exhibits a poor self‐repair ability after damages. 1 In an attempt to develop an appropriate method for cartilage defect repair, stem cell therapy that usually seeds bone‐marrow‐derived stem cells (BMSCs) i... |
10. 1002/advs. 201900218 | 2,019 | Advanced Science | Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification | Abstract Peptidomimetic low‐molecular‐weight hydrogelators, a class of peptide‐like molecules with various backbone amide modifications, typically give rise to hydrogels of diverse properties and increased stability compared to peptide hydrogelators. Here, a new peptidomimetic low‐molecular‐weight hydrogelator is desig... | Peptide hydrogels are solid‐like, biocompatible, and biodegradable supramolecular materials, which are hence especially suitable for biological and biomedical applications such as 3D cell culture, tissue engineering, and controlled drug release. 1, 2 Peptide hydrogels can also be utilized for other applications, such a... |
10. 1002/advs. 201900344 | 2,019 | Advanced Science | 3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts | Abstract Generation of thick vascularized tissues that fully match the patient still remains an unmet challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick, vascularized, and perfusable cardiac patches that completely match the immunological, cellular, biochemical, and anatomical properties... | 1 Introduction Cardiovascular diseases are the number one cause of death in industrialized nations. 1 To date, heart transplantation is the only treatment for patients with end‐stage heart failure. Since the number of cardiac donors is limited, there is a need to develop new approaches to regenerate the infarcted heart... |
10. 1002/advs. 201900520 | 2,019 | Advanced Science | Adaptable Microporous Hydrogels of Propagating NGF‐Gradient by Injectable Building Blocks for Accelerated Axonal Outgrowth | Abstract Injectable hydrogels in regeneration medicine can potentially mimic hierarchical natural living tissue and fill complexly shaped defects with minimally invasive implantation procedures. To achieve this goal, however, the versatile hydrogels that usually possess the nonporous structure and uncontrollable spatia... | 1 Introduction Injectable materials with highly integrated functionalities have considerable benefits for regenerative medicine owing to their potential ability to mimic hierarchical natural living tissue and guide tissue regeneration with minimally invasive implantation procedures. 1, 2 Because of their tunable proper... |
10. 1002/advs. 201900566 | 2,019 | Advanced Science | In Situ Subcellular Detachment of Cells Using a Cell‐Friendly Photoresist and Spatially Modulated Light | Abstract Dynamic adhesion and detachment of subcellular regions occur during cell migration, thus a technique allowing precise control of subcellular detachment of cells will be useful for cell migration study. Previous methods for cell detachment were developed either for harvesting cells or cell sheets attached on su... | 1 Introduction Regulated adhesion and detachment of cells is important for various processes in life, including development, homeostasis, wound healing, and immune responses. 1 Engineered surfaces controlling cell adhesion have been developed for implantable devices, tissue engineering, and fundamental study of cell bi... |
10. 1002/advs. 201900597 | 2,019 | Advanced Science | Fine‐Tunable and Injectable 3D Hydrogel for On‐Demand Stem Cell Niche | Abstract Stem‐cell‐based tissue engineering requires increased stem cell retention, viability, and control of differentiation. The use of biocompatible scaffolds encapsulating stem cells typically addresses the first two problems. To achieve control of stem cell fate, fine‐tuned biocompatible scaffolds with bioactive m... | 1 Introduction Stem cells constitute an emerging cell source for regenerative tissue engineering owing to their pluripotency, capacity for self‐renewal, and their potential to provide solutions for various human disorders, such as osteoarthritis and cardiac disease. 1 The potential of stem cell based tissue engineering... |
10. 1002/advs. 201900849 | 2,019 | Advanced Science | Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies | Abstract Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44‐targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44 + tumor cells in culture, and upon local administ... | 1 Introduction Bacterial inclusion bodies (IBs) are insoluble and discrete particles highly enriched by a single protein species, which deposits as interdigitated amyloidal fibers and nonamyloidal protein forms. 1 They organize into porous fibrilar networks 2 that confer mechanical stability, in which native or quasina... |
10. 1002/advs. 201900867 | 2,019 | Advanced Science | Osteochondral Regeneration with 3D‐Printed Biodegradable High‐Strength Supramolecular Polymer Reinforced‐Gelatin Hydrogel Scaffolds | Abstract Biomacromolecules with poor mechanical properties cannot satisfy the stringent requirement for load‐bearing as bioscaffolds. Herein, a biodegradable high‐strength supramolecular polymer strengthened hydrogel composed of cleavable poly( N ‐acryloyl 2‐glycine) (PACG) and methacrylated gelatin (GelMA) (PACG‐GelMA... | 1 Introduction Articular cartilage defects along with subchondral bone degeneration in the knee joint is a common clinical problem, which leads to knee joint dysfunction, significant pain, and even disability. 1, 2, 3, 4 What is worse, the degeneration of subchondral bone in cartilage defect may further aggravate osteo... |
10. 1002/advs. 201901041 | 2,019 | Advanced Science | Endoscopically Injectable Shear‐Thinning Hydrogels Facilitating Polyp Removal | Abstract Submucosal elevation, the process of instilling material in the submucosal space for separation of the surface mucosa and deeper muscularis layer, is a significant aspect of the endoscopic mucosal resection of large lesions performed to facilitate lesion removal and maximize safety. Submucosal injection, when ... | 1 Introduction Polypectomy remains the single intervention facilitating the interruption of polyp progression toward cancer. Approximately over 15 million colonoscopies are performed annually in the United States with ≈20–25% of these involving polypectomies many of which are performed with the aid of a submucosal inje... |
10. 1002/advs. 201901146 | 2,019 | Advanced Science | 3D Printing of Hot Dog‐Like Biomaterials with Hierarchical Architecture and Distinct Bioactivity | Abstract Hierarchical structure has exhibited an important influence in the fields of supercapacitors, catalytic applications, and tissue engineering. The hot dog, a popular food, is composed of bread and sausage with special structures. In this study, inspired by the structure of a hot dog, the strategy of combining d... | Hierarchical structure design is widely studied in various fields including supercapacitor, 1 catalytic applications, 2 and tissue engineering. 3 In the past decades, it is found that the micro/nanoscale hierarchical structures have great influences on material properties. 4 Thus, designing materials with specific micr... |
10. 1002/advs. 201901173 | 2,019 | Advanced Science | A Short Peptide Hydrogel with High Stiffness Induced by 3 | Abstract Biological gels generally require polymeric chains that produce long‐lived physical entanglements. Low molecular weight colloids offer an alternative to macromolecular gels, but often require ad‐hoc synthetic procedures. Here, a short biomimetic peptide composed of eight amino acid residues derived from squid ... | 1 Introduction Peptide hydrogels are increasingly explored for biomedical applications such as wound healing patches, 1, 2 cell culture scaffolds for tissue engineering, 3 drug delivery vehicles, 4 or as substrates to study stem cell differentiation. 5 Peptides are particularly attractive as building blocks for hydroge... |
10. 1002/advs. 201901198 | 2,020 | Advanced Science | Adult Tissue Extracellular Matrix Determines Tissue Specification of Human iPSC‐Derived Embryonic Stage Mesodermal Precursor Cells | Abstract The selection of pluripotent stem cell (PSC)‐derived cells for tissue modeling and cell therapy will be influenced by their response to the tissue environment, including the extracellular matrix (ECM). Whether and how instructive memory is imprinted in adult ECM and able to impact on the tissue specific determ... | 1 Introduction The control of interactions between cells and their environment is essential for tissue and disease modeling, and regenerative medicine. The extracellular matrix (ECM) serves as a key messenger between cells and the tissue environment by providing a dynamic scaffold. ECM‐embedded cues regulate organ home... |
10. 1002/advs. 201901240 | 2,019 | Advanced Science | Tissue‐Engineered Neural Network Graft Relays Excitatory Signal in the Completely Transected Canine Spinal Cord | Abstract Tissue engineering produces constructs with defined functions for the targeted treatment of damaged tissue. A complete spinal cord injury (SCI) model is generated in canines to test whether in vitro constructed neural network (NN) tissues can relay the excitatory signal across the lesion gap to the caudal spin... | 1 Introduction Spinal cord injury (SCI) causes irreversible tissue loss, including neurons in the gray matter and nerve tracts and oligodendrocytes in the white matter. 1 Spontaneous regeneration after SCI is limited, and there are no satisfactory interventions to enhance endogenous regeneration to replenish lost tissu... |
10. 1002/advs. 201901388 | 2,019 | Advanced Science | Self‐Healing Hydrogels and Cryogels from Biodegradable Polyurethane Nanoparticle Crosslinked Chitosan | Abstract Hydrogels are widely used in tissue engineering owing to their high water retention and soft characteristics. It remains a challenge to develop hydrogels with tunable degradation rates, proper environmental responsiveness, and injectability. In this study, biodegradable difunctional polyurethane (DFPU) nanopar... | 1 Introduction Hydrogels are polymers with high water retention, soft characteristics, and good biocompatibility, which gain wide applications in biomedical fields. Recent attention has been paid to environmentally responsive hydrogels, injectable hydrogels, self‐healing hydrogels, and cryogels as potential biomedical ... |
10. 1002/advs. 201901412 | 2,019 | Advanced Science | The miR‐193a‐3p‐MAP3k3 Signaling Axis Regulates Substrate Topography‐Induced Osteogenesis of Bone Marrow Stem Cells | Abstract Substrate topographical features induce osteogenic differentiation of bone marrow stem cells (BMSCs), but the underlying mechanisms are unclear. As microRNAs (miRNAs) play key roles in osteogenesis and bone regeneration, it would be meaningful to elucidate the roles of miRNAs in the intracellular signaling cas... | 1 Introduction Stem cells reside in a complex microenvironment in which extracellular biophysical cues, such as the topography and stiffness of the extracellular matrix (ECM), as well as various biochemical factors such as growth factors and hormones, play pivotal roles in effecting cell survival, self‐renewal, and dif... |
10. 1002/advs. 201901511 | 2,019 | Advanced Science | 2D MXene‐Integrated 3D‐Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction | Abstract The residual of malignant tumor cells and lack of bone‐tissue integration are the two critical concerns of bone‐tumor recurrence and surgical failure. In this work, the rational integration of 2D Ti 3 C 2 MXene is reported with 3D‐printing bioactive glass (BG) scaffolds for achieving concurrent bone‐tumor kill... | 1 Introduction Bone cancer is a general term for malignant bone tumors such as osteosarcoma, chondrosarcoma, and fibrosarcoma. 1 It is usually divided into autologous skeletal system cancer and bone‐metastases cancer (primary tumors in breast, lung, and kidney). 2 At present, the treatment of bone cancer usually combin... |
10. 1002/advs. 201901719 | 2,019 | Advanced Science | Formation of Polarized, Functional Artificial Cells from Compartmentalized Droplet Networks and Nanomaterials, Using One‐Step, Dual‐Material 3D‐Printed Microfluidics | Abstract The bottom‐up construction of synthetic cells with user‐defined chemical organization holds considerable promise in the creation of bioinspired materials. Complex emulsions, droplet networks, and nested vesicles all represent platforms for the engineering of segregated chemistries with controlled communication... | 1 Introduction The creation of artificial cells with functional properties, that are analogous to their biological counterparts, is envisaged to give rise to a wealth of opportunities, in a diversity of application areas, in both biotechnology and therapeutics, 1, 2, 3, 4, 5 for example, in tumor cell targeted drug del... |
10. 1002/advs. 201901818 | 2,020 | Advanced Science | Direct Conversion of Human Dermal Fibroblasts into Cardiomyocyte‐Like Cells Using CiCMC Nanogels Coupled with Cardiac Transcription Factors and a Nucleoside Drug | Abstract Using direct conversion technology, normal adult somatic cells can be routinely switched from their original cell type into specific differentiated cell types by inducing the expression of differentiation‐related transcription factors. In this study, normal human dermal fibroblasts (NHDFs) are directly convert... | 1 Introduction Heart failure, a major health problem associated with critical complications, is one of the most lethal diseases in the world. 1 When cardiomyocyte cells are damaged, they cannot be regenerated to restore the beating action of the heart. Therefore, complete heart transplantation is the only way to cure h... |
10. 1002/advs. 201901878 | 2,020 | Advanced Science | A 3D‐Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction | Abstract Advances in biomanufacturing techniques have opened the doors to recapitulate human sensory organs such as the nose and ear in vitro with adequate levels of functionality. Such advancements have enabled simultaneous targeting of two challenges in engineered sensory organs, especially the nose: i) mechanically ... | 1 Introduction The rapid growth of the biomedical engineering field in the past few decades has enabled the emergence of bionic organs, a highly serviceable asset for replicating specific organ functions and increasing the accuracy of in vitro test models, with the aim to eventually replace native organs. To create bio... |
10. 1002/advs. 201902295 | 2,019 | Advanced Science | Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing | Abstract Clinical translation of cell‐based products is hampered by their limited predictive in vivo performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue products through processes that mimic development and regeneration, a strategy applicable for the healing of large bone defects, ... | 1 Introduction Tissue‐engineered advanced therapy medicinal products (TE‐ATMPs) are poised to revolutionize health care by replacing or restoring the function of damaged organs. Although major advances in the field of cell therapy manufacturing have been witnessed, only a small fraction of TE‐ATMPs exhibit quality attr... |
10. 1002/advs. 201902307 | 2,020 | Advanced Science | Multi‐Material 3D and 4D Printing: A Survey | Abstract Recent advances in multi‐material 3D and 4D printing (time as the fourth dimension) show that the technology has the potential to extend the design space beyond complex geometries. The potential of these additive manufacturing (AM) technologies allows for functional inclusion in a low‐cost single‐step manufact... | 1 Introduction The world's major industrial countries are promoting 3D printing or additive manufacturing (AM) as a technology foundation of future manufacturing. Due to special characteristics of AM such as facile and customizable manufacturing, this method is being broadly used in many areas such as electronics, aero... |
10. 1002/advs. 201902326 | 2,019 | Advanced Science | Cell Adhesion, Morphology, and Metabolism Variation via Acoustic Exposure within Microfluidic Cell Handling Systems | Abstract Acoustic fields are capable of manipulating biological samples contained within the enclosed and highly controlled environment of a microfluidic chip in a versatile manner. The use of acoustic streaming to alter fluid flows and radiation forces to control cell locations has important clinical and life science ... | 1 Introduction The manipulation of biological matter has become widespread in microfluidics. 1, 2, 3 The benefits of operating at a reduced size scale have enabled highly efficient techniques for selective patterning and manipulating cells. 4, 5 Such approaches have been used for a wide range of tasks, including single... |
10. 1002/advs. 201902359 | 2,019 | Advanced Science | Recent Advances in Chemical Functionalization of 2D Black Phosphorous Nanosheets | Abstract Owing to their tunable direct bandgap, high charge carrier mobility, and unique in‐plane anisotropic structure, black phosphorus nanosheets (BPNSs) have emerged as one of the most important candidates among the 2D materials beyond graphene. However, the poor ambient stability of black phosphorus limits its pra... | 1 Introduction With the isolation of graphene in 2004, 2D materials have become a prime focus in material science research because of their extraordinary physicochemical properties such as large specific surface area, good mechanical strength, and high optical transparency. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14... |
10. 1002/advs. 201902398 | 2,020 | Advanced Science | Human Platelet Lysates‐Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion Assessment | Abstract Fundamental physiologic and pathologic phenomena such as wound healing and cancer metastasis are typically associated with the migration of cells through adjacent extracellular matrix. In recent years, advances in biomimetic materials have supported the progress in 3D cell culture and provided biomedical tools... | 1 Introduction The complexity and dynamism of the native tissue microenvironment are actively involved into distinct physiological and pathological events, where cell–cell and cell–extracellular matrix (ECM) communication plays a crucial role. 1, 2 In cancer, tumor cell signaling triggers the deregulation of the spatio... |
10. 1002/advs. 201902403 | 2,020 | Advanced Science | 4D Self‐Morphing Culture Substrate for Modulating Cell Differentiation | Abstract As the most versatile and promising cell source, stem cells have been studied in regenerative medicine for two decades. Currently available culturing techniques utilize a 2D or 3D microenvironment for supporting the growth and proliferation of stem cells. However, these culture systems fail to fully reflect th... | 1 Introduction The dynamic nature of the physiological environment in vivo plays an essential role in modulating cellular behaviors and functions, which is closely related to embryonic development, tissue self‐renewal or regeneration, wound healing, and disease progression over time. [ [qv: 1–3] ] Stem cell therapy has... |
10. 1002/advs. 201902420 | 2,019 | Advanced Science | Artificial Inclusion Bodies for Clinical Development | Abstract Bacterial inclusion bodies (IBs) are mechanically stable protein particles in the microscale, which behave as robust, slow‐protein‐releasing amyloids. Upon exposure to cultured cells or upon subcutaneous or intratumor injection, these protein materials secrete functional IB polypeptides, functionally mimicking... | Bacterial inclusion bodies (IBs) are water‐insoluble proteinaceous inclusions generated in the cytoplasm of recombinant bacteria, 1, 2 stabilized by an amyloid fibril architecture that confers mechanical robustness. 3 They are formed by the transgene protein product plus a diversity of residual macromolecules from bact... |
10. 1002/advs. 201902701 | 2,020 | Advanced Science | Crosslinking Induced Reassembly of Multiblock Polymers: Addressing the Dilemma of Stability and Responsivity | Abstract Physical or chemical crosslinking of polymeric micelles has emerged as a straightforward approach to overcome the intrinsic instability of assemblies. However, the crosslinking process may compromise the responsivity of nanosystems and result in inefficient release of payloads. To address this dilemma, a cross... | Self‐assembled polymeric micelles have been receiving much attention for potential use as versatile drug delivery systems. [ 1, 2, 3 ] They commonly consist of hydrophobic cores for protecting and solubilizing therapeutics and hydrophilic shells for improved colloidal stability and stealthy character. [ 4 ] To date, a ... |
10. 1002/advs. 201902740 | 2,020 | Advanced Science | An Alkaline Based Method for Generating Crystalline, Strong, and Shape Memory Polyvinyl Alcohol Biomaterials | Abstract Strong, stretchable, and durable biomaterials with shape memory properties can be useful in different biomedical devices, tissue engineering, and soft robotics. However, it is challenging to combine these features. Semi‐crystalline polyvinyl alcohol (PVA) has been used to make hydrogels by conventional methods... | 1 Introduction Engineered biomaterials have been increasingly recognized as a promising solution to overcome major hurdles in healthcare. [ 1 ] Development of stretchable and strong biomaterials with long‐term performance, chemical stability, and multifunctional properties can facilitate translating them into clinical ... |
10. 1002/advs. 201902872 | 2,020 | Advanced Science | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems | Abstract Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo wi... | 1 Introduction Bioresorbable materials that fully dissolve in the body with biologically benign byproducts provide a unique opportunity to engineer new electrical, optical, and sensing components into implantable biodegradable systems that eliminate any boundary with the human body, granting direct access to organs, ti... |
10. 1002/advs. 201902931 | 2,020 | Advanced Science | BMP‐2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP/TAZ | Abstract Growth factors and mechanical cues synergistically affect cellular functions, triggering a variety of signaling pathways. The molecular levels of such cooperative interactions are not fully understood. Due to its role in osteogenesis, the growth factor bone morphogenetic protein 2 (BMP‐2) is of tremendous inte... | 1 Introduction Chemical and physical cues act upon cells to mediate a wide range of behaviors, including growth, differentiation, and survival. [ 1, 2 ] Mechanotransduction enables cells to sense and respond to physical cues like extracellular matrix (ECM) viscoelasticity, ligand density, and topography. [ 3, 4, 5, 6 ]... |
10. 1002/advs. 201902953 | 2,020 | Advanced Science | Advances in Hybrid Fabrication toward Hierarchical Tissue Constructs | Abstract The diversity of manufacturing processes used to fabricate 3D implants, scaffolds, and tissue constructs is continuously increasing. This growing number of different applicable fabrication technologies include electrospinning, melt electrowriting, volumetric‐, extrusion‐, and laser‐based bioprinting, the Kenza... | 1 Introduction Using automatized technologies for the fabrication of hierarchical structures with the aim to obtain biologically functional tissue analogues has been an essential development within biofabrication. [ 1, 2 ] Such hierarchical 3D tissue constructs have broad applicability including for drug screening, [ 3... |
10. 1002/advs. 201903027 | 2,019 | Advanced Science | Pressure‐Driven Two‐Input 3D Microfluidic Logic Gates | Abstract Microfluidics is a continuously growing field with potential not only in the fields of medical, chemical, and bioanalysis, but also in the domains of optics and information technology. Here, a pressure‐driven 3D microfluidic chip is demonstrated with multiple logic Boolean functions. The presence and absence o... | Recent developments in microfluidics 1 are tackling technological challenges in a wide range of applications including chemistry, 2 3D printing, 3 tissue engineering, 4 drugs development, 5 biomedical research, 6 and most lately organs‐on‐chip. 7, 8 Particularly, microfluidic devices which enable the handling of except... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.