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10. 1002/ca. 23318 | 2,019 | Clinical Anatomy (New York, N. y. ) | Human embryonic stem cells: Distinct molecular personalities and applications in regenerative medicine | The field of stem cell biology is exciting because it provides researchers and clinicians with seemingly unlimited applications for treating many human diseases. Stem cells are a renewable source of pluripotent cells that can differentiate into nearly all human cell types. In this article we focus particularly on human... | INTRODUCTION The evolution of biological knowledge, and the use of human embryonic stem (hES) cells following the first report of their derivation from mouse blastocysts in 1981, has given birth to an exciting field, motivating further study of human cell development and differentiation. The level of interest in this f... |
10. 1002/cac2. 12224 | 2,021 | Cancer Communications | Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy | Abstract Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell type, spatial organization, and microenvironment but also have adverse effects in stem cell cultures, whereas PDX are expensive wit... | Abbreviations 3D three‐dimensional ALI air‐liquid interface CRC colorectal cancer CRISPR‐HOT CRISPR‐Cas9‐mediated homology‐independent organoid transgenesis CSCs cancer stem cells DACH1 Dachshund homologue 1 ECM extracellular matrix ERBB3 Erb‐b2 receptor tyrosine kinase 3 HCC hepatocellular carcinoma MEK1/2 mitogen‐act... |
10. 1002/cac2. 12255 | 2,022 | Cancer Communications | Multifunctional inorganic nanomaterials for cancer photoimmunotherapy | Abstract Phototherapy and immunotherapy in combination is regarded as the ideal therapeutic modality to treat both primary and metastatic tumors. Immunotherapy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination. Phototherapy destroys the primary tumor... | Abbreviations APC antigen‐presenting cell AuNPs Gold nanoparticles BP Black phosphorus BPNS Black phosphorus nanosheet BPQD Black phosphorus quantum dot CAR chimeric antigen receptor Ce6 chlorin e6 CNT carbon nanotube CTL cytotoxic T lymphocyte CuS nanoparticles copper sulfide nanoparticles DC dendritic cell DOX doxoru... |
10. 1002/cam4. 1413 | 2,018 | Cancer Medicine | Proceedings of International Conference on Cell Death in Cancer and Toxicology | No abstract available | Signaling by apoptotic cells in development and cancer A. Perez‐Garijo & H. Steller The Rockefeller University, New York, NY, USA Email: Hermann. Steller@rockefeller. edu Apoptotic cells can produce signals to instruct cells in their local environment, including factors that stimulate proliferation. This apoptosis‐indu... |
10. 1002/cam4. 6303 | 2,023 | Cancer Medicine | Primary cardiac sarcomas: A clinicopathologic study in a single institution with 25 years of experience with an emphasis on | Abstract Background Primary cardiac sarcomas are rare and their clinicopathologic features are heterogeneous. Among them, particularly intimal sarcoma is a diagnostic challenge due to nonspecific histologic features. Recently, MDM2 amplification reported to be a characteristic genetic event in the intimal sarcoma. In t... | 1 INTRODUCTION Primary cardiac tumors are rare and the incidence in the early autopsy series ranged from 0. 001% to 0. 3%. 1 Approximately 75% of primary cardiac tumors are benign such as cardiac myxomas, with the remaining 25% of showing malignancy, the majority of which are is sarcomas. 2 Most cardiac sarcomas have b... |
10. 1002/cam4. 6800 | 2,024 | Cancer Medicine | null | Abstract RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in biotechnology and medi... | 1 INTRODUCTION Three amino acids compose the structure of the RGD peptide: arginine (Arg), glycine (Gly), and aspartic acid (Asp). The RGD motif is formed by a linear arrangement of these amino acids. 1, 2 This peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinoge... |
10. 1002/cbf. 3112 | 2,015 | Cell Biochemistry and Function | An | Biomimetic scaffolds hold great promise for therapeutic repair of cartilage, but although most scaffolds are tested with cells in vitro, there are very few ex vivo models (EVMs) where adult cartilage and scaffolds are co-cultured to optimize their interaction prior to in vivo studies. This study describes a simple, non... | Introduction Articular cartilage is a form of hyaline cartilage that covers the bony articulating ends of synovial joints. This stiff load-bearing tissue resists tensile forces, compression and shearing, while maintaining some resilience and elasticity. The unique biomechanical properties of articular cartilage are att... |
10. 1002/cbf. 3173 | 2,016 | Cell Biochemistry and Function | Large animal models of cardiovascular disease | The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal mammalian processes. Despite our advancing knowledge and understandin... | Introduction The mammalian cardiovascular system is a vast network of specialized structures and vessels, which allows blood and other important molecules to be transported throughout the body. Central to the system is the four‐chambered heart that acts as a muscular pump to permit the movement of blood. Four cardiac v... |
10. 1002/cbf. 3175 | 2,016 | Cell Biochemistry and Function | Synergistic effect of bioactive lipid and condition medium on cardiac differentiation of human mesenchymal stem cells from different tissues | Human umbilical cord mesenchymal stem cells (hUCMSCs) and human adipose tissue mesenchymal stem cells (hATMSCs) have the potential to differentiate into cardiomyocytes, making them promising therapeutic candidates for treating damaged cardiac tissues. Currently, however, the differentiated cells induced from hUCMSCs or... | Introduction Mesenchymal stem cells (MSCs) have the ability to differentiate into various types of tissue cells. This property is of enormous potential to clinical applications in tissue regeneration covering bone, cartilage, muscle and adipose. 1, 2, 3 A number of recent reports have shown that MSCs could also differe... |
10. 1002/cbic. 201500205 | 2,015 | Chembiochem | A Recombinant Collagen–mRNA Platform for Controllable Protein Synthesis | We have developed a collagen–mRNA platform for controllable protein production that is intended to be less prone to the problems associated with commonly used mRNA therapy as well as with collagen skin-healing procedures. A collagen mimic was constructed according to a recombinant method and was used as scaffold for tr... | Local protein deficiency is a main cause of medical problems ranging from local injury, wounds or surgery that can lead to death to disability or genetic disorders such as cystic fibrosis (CF). [ 1 ] Direct injection of the relevant proteins into the tissue might require repeated injections that could cause severe side... |
10. 1002/cbic. 201800606 | 2,019 | Chembiochem | From Bugs to Bioplastics: Total (+)‐Dihydrocarvide Biosynthesis by Engineered | Abstract The monoterpenoid lactone derivative (+)‐dihydrocarvide ((+)‐DHCD) can be polymerised to form shape‐memory polymers. Synthetic biology routes from simple, inexpensive carbon sources are an attractive, alternative route over chemical synthesis from ( R )‐carvone. We have demonstrated a proof‐of‐principle in viv... | Introduction The increasing popularity of non‐petroleum‐based biopolymer applications is driven by concerns over dwindling fossil fuel supplies and the environmental impact of accumulating non‐biodegradable plastic waste. 1 Industrially relevant biodegradable polymers include elastomers, resins and composites, which ar... |
10. 1002/cbic. 202000744 | 2,020 | Chembiochem | Optical Biosensors for Virus Detection: Prospects for SARS‐CoV‐2/COVID‐19 | Abstract The recent pandemic of the novel coronavirus disease 2019 (COVID‐19) has caused huge worldwide disruption due to the lack of available testing locations and equipment. The use of optical techniques for viral detection has flourished in the past 15 years, providing more reliable, inexpensive, and accurate detec... | Introduction The novel coronavirus disease 2019 (COVID‐19) has caused an unprecedented surge in virus research, in particular improving testing and diagnostics. The rapid global spread of COVID‐19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and slow and sometimes inaccurate testing has h... |
10. 1002/cbic. 202100266 | 2,021 | Chembiochem | An Advanced ‘clickECM’ That Can be Modified by the Inverse‐Electron‐Demand Diels‐Alder Reaction | Abstract The extracellular matrix (ECM) represents the natural environment of cells in tissue and therefore is a promising biomaterial in a variety of applications. Depending on the purpose, it is necessary to equip the ECM with specific addressable functional groups for further modification with bioactive molecules, f... | Introduction The extracellular matrix (ECM) is a complex network of various macromolecules, which is synthesized and assembled by the residing cells of a tissue. The main components of ECM are fibrous and non‐fibrous collagens and various glycosaminoglycans and proteoglycans as well as adhesion proteins and enzymes. As... |
10. 1002/cbic. 202100427 | 2,021 | Chembiochem | Modulation of Transaminase Activity by Encapsulation in Temperature‐Sensitive Poly( | Abstract Smart hydrogels hold much potential for biocatalysis, not only for the immobilization of enzymes, but also for the control of enzyme activity. We investigated upper critical solution temperature‐type poly N ‐acryloyl glycinamide (pNAGA) hydrogels as a smart matrix for the amine transaminase from Bacillus megat... | Introduction Enzymatic cascades are a valuable alternative to traditional step‐wise chemical synthetic processes, since substrate specificity, stereo‐ and regioselectivity of enzymes are typically outstanding. Especially for products with challenging stereo conformation, they can help to avoid expensive and time‐consum... |
10. 1002/cbic. 202200196 | 2,022 | Chembiochem | Multivalent γ‐PGA‐Exendin‐4 Conjugates to Target Pancreatic β‐Cells | Abstract Targeting of glucagon‐like peptide 1 receptor (GLP‐1R), expressed on the surface of pancreatic β‐cells, is of great interest for the development of advanced therapies for diabetes and diagnostics for insulinoma. We report the conjugation of exendin‐4 (Ex‐4), an approved drug to treat type 2 diabetes, to poly‐γ... | Introduction Type 2 diabetes is an unresolved pathology, related to genetic and environmental factors, which gradually decline the pancreatic islet functionality, finally culminating in a pathological phenomenon defined as hyperglycemia. Pancreatic β‐cells take on a key role in the so‐called glucose homeostasis by secr... |
10. 1002/ccd. 28529 | 2,019 | Catheterization and Cardiovascular Interventions | Initial experiences with a novel biodegradable device for percutaneous closure of atrial septal defects: From preclinical study to first‐in‐human experience | Abstract Objective To evaluate the feasibility, safety, and effectiveness of a novel, absorbable atrial septal defect (ASD) closure device made of poly‐ l ‐lactic acid (PLLA) in a swine model of ASD and for the first time in humans. Methods A preclinical safety study was conducted using a swine model of ASD. In a clini... | 1 INTRODUCTION An atrial septal defect (ASD) is a common cardiac congenital anomaly accounting for about 30% of cases of congenital heart disease. With the development of interventions and cardiac catheterization, percutaneous closure has become the first‐line therapy for ASD patients. To date, all available devices fo... |
10. 1002/ccr3. 2614 | 2,019 | Clinical Case Reports | Revascularization and vital pulp therapy in immature molars with necrotic pulp and irreversible pulpitis: A case report with two‐year follow‐up | Abstract Management of teeth with inflamed pulp has been always a challenge. Revascularization and vital pulp therapy are suggested as procedures for successful treatment of immature molars diagnosed with pulp necrosis and irreversible pulpitis, respectively. | 1 INTRODUCTION Traditionally, the management of immature teeth with necrotic pulp or irreversible pulpitis has been always a challenge in endodontics. This is not encountered in adult patients and may be due to the wide‐open root apex and thin dentin walls of an immature tooth. The treatment options for such immature t... |
10. 1002/ccr3. 3057 | 2,020 | Clinical Case Reports | Self‐regeneration of an extensive bony defect following mandibular resection | Abstract Spontaneous bone regeneration is a rapid and uncommon formation of new bone in a previous bone defect. Preservation of periosteum as the main source of osteogenesis, young age, and genetics are possible important factors related to this phenomenon. | 1 INTRODUCTION Spontaneous bone regeneration has been reported following mandibular resection in both growing patients and adults. The phenomenon has been observed in small and wide mandibular defects, even in total mandibulectomies. In most of the reported cases, mandibular body or ramus showed rapid spontaneous regen... |
10. 1002/ccr3. 3386 | 2,020 | Clinical Case Reports | Osseointegrated implant‐retained auricular prosthesis constructed using cone‐beam computed tomography and a prosthetically driven digital workflow: a case report | Abstract Prosthetically driven workflows using CBCT, digital optical scanning, 3D‐printed molds and frameworks, and dental implant component attachments to osseointegrated fixtures can produce anatomically accurate, esthetic, durable silicone ear replacements. | 1 INTRODUCTION The right ear of a 55‐year‐old man was replaced using a digital workflow. Osseointegrated implants in the right mastoid were fitted with abutments and snap attachments (indexed to a 3D‐printed chrome‐cobalt framework). The final silicone prosthesis was fabricated using optical scanning and a 3D‐printed r... |
10. 1002/ccr3. 3696 | 2,021 | Clinical Case Reports | Regenerative Endodontic Therapy using a New Antibacterial Root Canal Cleanser in necrotic immature permanent teeth: Report of two cases treated in a single appointment | A case of regenerative endodontics: (a) before treatment; (b) post‐treatment Xray; (c) follow‐up at 6 months; (d) follow‐up at 12 months. | Key Clinical Message The present report demonstrates that desiccant agent Hybenx cleanser could be used successfully in necrotic teeth with incomplete root development and apical lesion to realize single appointment regenerative endodontic therapy. CLINICAL RELEVANCE Scientific rationale for the study: Patients with im... |
10. 1002/ccr3. 6355 | 2,022 | Clinical Case Reports | null | Abstract This case report describes a peculiar and innovative fixing procedure with a Poly‐D, L‐lactic acid (PDLLA) polymer in the unusual case of magnet dislodgment and rupture of the cochlear implant (CI) silicone sheath holding the magnet. | 1 INTRODUCTION Poly‐D, L‐lactic Acid (PDLLA) is a biodegradable and biocompatible random amorphous copolymer, composed of a mixture of D and L‐isomers of polylactic acid. It has been used either as a vehicle for drug delivery, or in dentistry and in craniomaxillofacial surgery for bone regeneration and tissue engineeri... |
10. 1002/ccr3. 6596 | 2,022 | Clinical Case Reports | Anaphylaxis induced by intra‐articular injection of chitosan: A case report and literature review | Abstract Generally, we consider chitosan being a safe, nontoxic natural polymer with wide clinical applications. However, allergic reactions caused by chitosan have been reported on rare occasions. We report here a case of allergy and perform a literature review. | 1 INTRODUCTION Chitosan is a natural polymer obtained by alkaline deacetylation of chitin, which is the second most abundant polysaccharide after cellulose (Figure 1 ). 1 Chitosan has a number of special physicochemical properties such as biodegradability, biocompatibility, hemostatic and antibacterial activity (Figure... |
10. 1002/ccr3. 8630 | 2,024 | Clinical Case Reports | Experimental study on dimensional variations of 3D printed dental models based on printing orientation | Key Clinical Message This research investigates the trueness and precision of 3D printing technology in dental applications, specifically focusing on dimensional variations observed in models printed at different angles. The methodology involved importing a dental model into slicing software, adjusting its orientation,... | 1 INTRODUCTION The initiation of 3D printing took place with Charles Hull's introduction of stereolithography (SLA) technology in 1980. The continuous advancement of this technology led to notable progress, prompting Charles Hull to establish 3D Systems in 1986, thereby contributing significantly to the scientific evol... |
10. 1002/cdt3. 77 | 2,023 | Chronic Diseases and Translational Medicine | Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality? | Abstract Induced pluripotent stem cell (iPSC) technology is one of the de novo approaches in regeneration medicine and has led to new research applications for wound healing in recent years. Fibroblasts have attracted wide attention as the first cell line used for differentiation into iPSCs. Researchers have found that... | 1 INTRODUCTION Stem cell techniques have become a recent focus in biomedicine, particularly methods using induced pluripotent stem cells (iPSCs). Among the de novo approaches in regeneration medicine, iPSC is one such technology and has led to new research applications in wound healing. The first iPSCs were reprogramme... |
10. 1002/chem. 201700793 | 2,017 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Supramolecular Amino Acid Based Hydrogels: Probing the Contribution of Additive Molecules using NMR Spectroscopy | Abstract Supramolecular hydrogels are composed of self‐assembled solid networks that restrict the flow of water. l ‐Phenylalanine is the smallest molecule reported to date to form gel networks in water, and it is of particular interest due to its crystalline gel state. Single and multi‐component hydrogels of l ‐phenyla... | Introduction Hydrogels are semi‐solid colloidal materials which contain a three‐dimensional (3D) network with a fine structure that can often be defined by non‐covalent interactions. 1, 2 They contain large amounts of water, entrapped by capillary and surface forces, 1, 2 which provide liquid‐like properties to these s... |
10. 1002/chem. 201705567 | 2,018 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Recent Advances in Germanium‐Based Photoinitiator Chemistry | Abstract Acylgermanes provide an outstanding photoinduced reactivity at very useful absorption wavelengths. This encouraged multidisciplinary research groups to utilize them as highly effective and non‐toxic photoinitiators particularly for medical applications. In this Minireview, we present the most recent breakthrou... | Introduction In the last decades the demand and application of high performance photochemically produced polymers has been immensely growing. Nowadays, their use is no longer restricted to the manufacture of micro‐electronic devices, coatings, adhesives, inks, printing plates, optical waveguides but also enters fields ... |
10. 1002/chem. 201806042 | 2,019 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Light‐Responsive Arylazopyrazole Gelators: From Organic to Aqueous Media and from Supramolecular to Dynamic Covalent Chemistry | Abstract Versatile photoresponsive gels based on tripodal low molecular weight gelators (LMWGs) are reported. A cyclohexane‐1, 3, 5‐tricarboxamide (CTA) core provides face‐to‐face hydrogen bonding and a planar conformation, inducing the self‐assembly of supramolecular polymers. The CTA core was substituted with three a... | Introduction Low molecular weight gelators (LMWGs) represent a viable alternative for the development of soft materials. 1, 2, 3, 4 They can self‐assemble through noncovalent interactions, such as hydrogen bonding, 5, 6 host–guest (e. g. crown ether–cation), 7 metal–ligand, 8, 9, 10, 11 and π–π interactions, 12, 13 for... |
10. 1002/chem. 201903819 | 2,020 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Polymeric Photoacids Based on Naphthols—Design Criteria, Photostability, and Light‐Mediated Release | Abstract The implementation of photoswitches within polymers offers an exciting toolbox in the design of light‐responsive materials as irradiation can be controlled both spatially and temporally. Herein, we introduce a range of water‐soluble copolymers featuring naphthol‐based chromophores as photoacids in the side cha... | Introduction Various research fields benefit from advances in the design of molecular photoswitches, 1 as light offers considerable advantages over other triggers (e. g. , temperature or pH) including the possibility to control chemistry both spatially and temporally. Such photoswitches predominantly comprise organic c... |
10. 1002/chem. 202001238 | 2,020 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Turning Cell Adhesions ON or OFF with High Spatiotemporal Precision Using the Green Light Responsive Protein CarH | Abstract Spatiotemporal control of integrin‐mediated cell adhesions to extracellular matrix regulates cell behavior with has numerous implications for biotechnological applications. In this work, two approaches for regulating cell adhesions in space and time with high precision are reported, both of which utilize green... | The cell adhesions to their extracellular matrix (ECM) are of fundamental importance in cell biology, and they are strictly regulated in space and time during different cellular processes including cell migration, 1 differentiation, 2 division 3 and apoptosis. 4 As such biomimetic synthetic materials have provided grea... |
10. 1002/chem. 202001349 | 2,020 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Self‐Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Applications | Abstract This Full Paper reports the formation of silver (Ag) NPs within spatially resolved two‐component hydrogel beads, which combine a low‐molecular‐weight gelator (LMWG) DBS‐CONHNH 2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed through in situ reduction of Ag I, with the resulting nanoparticle‐... | Introduction Hydrogels self‐assembled from low‐molecular‐weight gelators (LMWGs) have seen intensive development in recent years for different types of biological applications including cell culture, 1 tissue engineering, 2 drug delivery, 3 antimicrobial therapy 4 and wound healing. 5 These materials are obtained from ... |
10. 1002/chem. 202003779 | 2,020 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Photochemical Methods for Peptide Macrocyclisation | Abstract Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new, diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocyclisation of peptides and small proteins. T... | Introduction Peptides and small proteins (collectively, PSPs) represent an exciting and emerging frontier in drug discovery, combining the advantages of modularity and synthetic flexibility of small molecules (<500 Da) with the exquisite levels of selectivity and potency of biologics (>5000 Da). [ 1, 2, 3 ] PSPs are pa... |
10. 1002/chem. 202005257 | 2,021 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Biological and Medical Applications of Calcium Phosphate Nanoparticles | Abstract Calcium phosphate nanoparticles have a high biocompatibility and biodegradability due to their chemical similarity to human hard tissue, for example, bone and teeth. They can be used as efficient carriers for different kinds of biomolecules such as nucleic acids, proteins, peptides, antibodies, or drugs, which... | Introduction Nanoparticles have a high surface‐to‐volume ratio which causes their specific physicochemical, biological, optical, electrical, and catalytic properties. In general, he application of nanoparticles in biology and medicine is a rapidly growing field, for example, the efficient targeted delivery of drugs and... |
10. 1002/chem. 202100490 | 2,021 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Urea‐Urease Reaction in Controlling Properties of Supramolecular Hydrogels: Pros and Cons | Abstract Supramolecular hydrogels are useful in many areas such as cell culturing, catalysis, sensing, tissue engineering, drug delivery, environmental remediation and optoelectronics. The gels need specific properties for each application. The properties arise from a fibrous network that forms the matrix. A common met... | 1 Introduction There has been a recent surge of attention into the development of self‐assembled molecules as functional materials. Among various self‐assembled systems, supramolecular hydrogels are fascinating soft materials having multifunctional applications in various fields including optoelectronics and biomateria... |
10. 1002/chem. 202102007 | 2,021 | Chemistry (Weinheim an Der Bergstrasse, Germany) | The Introduction of a Cysteine Residue Modulates The Mechanical Properties of Aromatic‐Based Solid Aggregates and Self‐Supporting Hydrogels | Abstract Peptide‐based hydrogels, originated by multiscale self‐assembling phenomenon, have been proposed as multivalent tools in different technological areas. Structural studies and molecular dynamics simulations pointed out the capability of completely aromatic peptides to gelificate if hydrophilic and hydrophobic f... | Introduction Amino acids and peptides are crucial entities in biological systems, covering functional and structural roles. Due to their biocompatibility, easy accessibility and well‐known chemistry, they have been widely used as constitutive and versatile elements for the generation of supramolecular architectures, in... |
10. 1002/chem. 202102472 | 2,021 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Self‐Propelling Hybrid Gels Incorporating an Active Self‐Assembled, Low‐Molecular‐Weight Gelator | Abstract Hybrid gel beads based on combining a low‐molecular‐weight gelator (LMWG) with a polymer gelator (PG) demonstrate an enhanced ability to self‐propel in water, with the LMWG playing an active role. Hybrid gel beads were loaded with ethanol and shown to move in water owing to the Marangoni effect changes in surf... | Introduction Self‐assembled hydrogels are fascinating, responsive soft materials with potential applications ranging from environmental regeneration to tissue engineering. They self‐assemble from low‐molecular‐weight gelators (LMWGs) and hence benefit from the synthetic programmability of these building blocks and the ... |
10. 1002/chem. 202104191 | 2,022 | Chemistry (Weinheim an Der Bergstrasse, Germany) | From Light to Structure: Photo Initiators for Radical Two‐Photon Polymerization | Abstract Two‐photon polymerization (2PP) represents a powerful technique for the fabrication of precise three‐dimensional structures on a micro‐ and nanometer scale for various applications. While many review articles are focusing on the used polymeric materials and their application in 2PP, in this review the class of... | 1 Introduction 1. 1 Two‐photon polymerization and photo initiators In 1931, Maria Göppert‐Mayer postulated the theoretical possibility of the two‐photon absorption (2PA) by one molecule in her doctoral thesis. In this process, the energies of two photons add up during simultaneous absorption and stimulate the molecule ... |
10. 1002/chem. 202200693 | 2,022 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer | Abstract Self‐assembly of biomolecules such as peptides, nucleic acids or their analogues affords supramolecular objects, exhibiting structures and physical properties dependent on the amino‐acid or nucleobase composition. Conjugation of the peptide diphenylalanine (FF) to peptide nucleic acids triggers formation of se... | Introduction The obtainment of supramolecular structures upon self‐assembly of natural building blocks, such as small peptides, nucleic acids or hybrid systems has attracted intense research interest during last years. These assemblies, in fact, are easy to produce and biocompatible and for these reasons they are parti... |
10. 1002/chem. 202202156 | 2,022 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Hydrophilic Chitosan Derivatives: Synthesis and Applications | Abstract Polymer alternatives sourced from nature have attracted increasing attention for applications in medicine, cosmetics, agriculture, food, water purification, and more. Among them, chitosan is the most versatile due to its full biodegradability, exceptional biocompatibility, multipurpose bioactivity, and low tox... | Introduction Chitosan, the deacetylated version of the second most abundant biopolymer chitin, has emerged as a promising nature‐sourced functional material. [ 1, 2, 3 ] This polysaccharide is produced from renewable resources such as shellfish, exoskeletons of insects, and fungi cell walls and is, therefore, a nontox... |
10. 1002/chem. 202202633 | 2,022 | Chemistry (Weinheim an Der Bergstrasse, Germany) | Divergent Synthesis of Ultrabright and Dendritic Xanthenes for Enhanced Click‐Chemistry‐Based Bioimaging | Abstract Biorthogonal labelling with fluorescent small molecules is an indispensable tool for diagnostic and biomedical applications. In dye‐based 5‐ethynyl‐2′‐deoxyuridine (EdU) cell proliferation assays, augmentation of the fluorescent signal entails an overall enhancement in the sensitivity and quality of the method... | Introduction In the field of bioimaging and diagnostics, fluorescent labelling has emerged as a potent tool for the elucidation of structures, dynamics, interactions and functions of biomolecules such as proteins, nucleic acids, polysaccharides and lipids. Furthermore, efficient fluorescence resonance energy transfer ... |
10. 1002/cjp2. 60 | 2,016 | The Journal of Pathology: Clinical Research | Comparative analysis of morphological and molecular motifs in bronchiolitis obliterans and alveolar fibroelastosis after lung and stem cell transplantation | Abstract Chronic lung allograft dysfunction (CLAD) remains the major obstacle to long‐term survival following lung transplantation (LuTx). Morphologically CLAD is defined by obliterative remodelling of the small airways (bronchiolitis obliterans, BO) as well as a more recently described collagenous obliteration of alve... | Abbreviations AFE alveolar fibroelastosis ALK1 activin receptor‐like kinase 1 BAL bronchoalveolar lavage BMP bone morphogenetic protein BO bronchiolitis obliterans BOOP bronchiolitis obliterans organizing pneumonia BOS bronchiolitis obliterans syndrome CCL5 chemokine (C‐C motif) ligand 5 CLAD chronic lung allograft dys... |
10. 1002/cm. 21553 | 2,019 | Cytoskeleton (Hoboken, N. j. ) | Functional regeneration of tissue engineered skeletal muscle | Abstract Skeletal muscle has a high regenerative capacity, injuries trigger a regenerative program which restores tissue function to a level indistinguishable to the pre‐injury state. However, in some cases where significant trauma occurs, such as injuries seen in military populations, the regenerative process is overw... | Abbreviations DM differentiation medium ECM extracellular matrix GM growth medium MPC myogenic precursor cell 1 INTRODUCTION For the majority of individuals skeletal muscle injuries are regenerative, restoring function to a level indistinguishable from that seen before injury. The severity of muscle wounds seen in clin... |
10. 1002/cm. 21658 | 2,021 | Cytoskeleton (Hoboken, N. j. ) | Cytoskeletal prestress: The cellular hallmark in mechanobiology and mechanomedicine | Abstract Increasing evidence demonstrates that mechanical forces, in addition to soluble molecules, impact cell and tissue functions in physiology and diseases. How living cells integrate mechanical signals to perform appropriate biological functions is an area of intense investigation. Here, we review the evidence of ... | 1 BACKGROUND AND INTRODUCTION Force, body structure and mechanics, and movements in animals and humans have been recognized for centuries by the giants like Aristotle, Archimedes, da Vinci, Galileo, Newton, and Borelli (Fung, 1981 ). In the second half of the 19th century, Julies Wolff postulated Wolff's law that the b... |
10. 1002/cmdc. 202200142 | 2,022 | Chemmedchem | Functional Nanomaterials in Biomedicine: Current Uses and Potential Applications | Abstract Nanomaterials, that is, materials made up of individual units between 1 and 100 nanometers, have lately involved a lot of attention since they offer a lot of potential in many fields, including pharmacy and biomedicine, owed to their exceptional physicochemical properties arising from their high surface area a... | 1 Introduction Due to their exceptional physicochemical properties arising from their high surface area and nanoscale size, nanomaterials have lately involved a lot of attention since they offer a lot of potential in many fields, particularly in pharmacy and biomedicine, for cancer treatment, drug/gene delivery, tissue... |
10. 1002/cmdc. 202300258 | 2,023 | ChemMedChem | Peptide Assemblies for Cancer Therapy | Supramolecular assemblies made by the self-assembly of peptides are finding an increasing number of applications in various fields. While the early exploration of peptide assemblies centered on tissue engineering or regenerative medicine, the recent development has shown that peptide assemblies can act as supramolecula... | No full text available |
10. 1002/cnm. 2734 | 2,016 | International Journal for Numerical Methods in Biomedical Engineering | Patient specific modeling of palpation‐based prostate cancer diagnosis: effects of pelvic cavity anatomy and intrabladder pressure | Summary Computational modeling has become a successful tool for scientific advances including understanding the behavior of biological and biomedical systems as well as improving clinical practice. In most cases, only general models are used without taking into account patient‐specific features. However, patient specif... | 1 Introduction Cross‐disciplinary research between engineering and medicine has resulted in significant advances in clinical diagnostics and treatments for cancer such as magnetic resonance imaging (MRI) and radiotherapy. More importantly for this work, computational modeling has become a useful predictive tool, which ... |
10. 1002/cnm. 3342 | 2,020 | International Journal for Numerical Methods in Biomedical Engineering | Fluid flow‐induced cell stimulation in bone tissue engineering changes due to interstitial tissue formation in vitro | Abstract In tissue engineering experiments in vitro, bioreactors have been used for applying wall shear stress (WSS) on cells to regulate cellular activities. To determine the loading conditions within bioreactors and to design tissue engineering products, in silico models are used. Previous in silico studies in bone t... | Novelty Mechanical stimulation in terms of fluid‐induced wall shear stress (WSS) can affect the activity of cells. In tissue engineering experiments in vitro, bioreactors have been used for applying WSS on cells. To determine the loading conditions within bioreactors and to design tissue engineering products (e. g. , s... |
10. 1002/cnma. 201900146 | 2,019 | ChemNanoMat : chemistry of nanomaterials for energy, biology and more | Flexible and Stretchable PEDOT-Embedded Hybrid Substrates for Bioengineering and Sensory Applications | Herein, we introduce a flexible, biocompatible, robust and conductive electrospun fiber mat as a substrate for flexible and stretchable electronic devices for various biomedical applications. To impart the electrospun fiber mats with electrical conductivity, poly(3, 4-ethylenedioxythiophene) (PEDOT), a conductive polym... | No full text available |
10. 1002/cpch. 51 | 2,018 | Current protocols in chemical biology | Endotoxin-Free Preparation of Graphene Oxide and Graphene-based Materials for Biological Applications | Due to their two-dimensional structure and unique properties, graphene and its derivatives have been extensively studied for their potential applications in various fields ranging from electronics to composites. Particularly, their high surface area, electrical conductivity, mechanical strength, dispersability in aqueo... | No full text available |
10. 1002/cpch. 85 | 2,020 | Current protocols in chemical biology | Azide-terminated RAFT Polymers for Biological Applications | Reversible addition−fragmentation chain-transfer (RAFT) polymerization is a commonly used polymerization methodology to generate synthetic polymers. The product of RAFT polymerization, i. e. RAFT polymers, have been widely employed in several biologically relevant areas, including drug delivery, biomedical imaging, and... | No full text available |
10. 1002/cphc. 202000162 | 2,020 | Chemphyschem | Multivalent ions and biomolecules: Attempting a comprehensive perspective | Abstract Ions are ubiquitous in nature. They play a key role for many biological processes on the molecular scale, from molecular interactions, to mechanical properties, to folding, to self‐organisation and assembly, to reaction equilibria, to signalling, to energy and material transport, to recognition etc. Going beyo... | 1 Introduction, motivation and scope In this review, we will focus on effects induced in biological and chemical systems by multivalent ions. While general overviews of the influences of electrostatics on soft matter are given, e. g. , in Refs. [1–3], it is generally accepted that the effects of multivalent ions go bey... |
10. 1002/cphc. 202000273 | 2,020 | Chemphyschem | The Effect of Number of Arms on the Aggregation Behavior of Thermoresponsive Poly( | Abstract The thermoresponsive nature of aqueous solutions of poly( N ‐isopropylacrylamide) (PNIPAAM) star polymers containing 2, 3, 4, and 6 arms has been investigated by turbidity, dynamic light scattering, rheology, and rheo‐SALS. Simulations of the thermosensitive nature of the single star polymers have also been co... | 1 Introduction Thermoresponsive polymers are interesting for numerous applications such as drug and gene delivery, 1, 2, 3 imaging of cancer cells and tumors, 3, 4, 5 tissue engineering, 6 extraction of oil from sand, 7 enhanced oil recovery, 8 energy saving devices, 9, 10 and desalination of seawater. 11, 12 One of th... |
10. 1002/cphc. 202000769 | 2,020 | Chemphyschem | Graphene‐Based Antimicrobial Biomedical Surfaces | Abstract Biomedical application of graphene derivatives have been intensively studied in last decade. With the exceptional structural, thermal, electrical, and mechanical properties, these materials have attracted immense attention of biomedical scientists to utilize graphene derivatives in biomedical devices to improv... | 1 Introduction Nosocomial infection, which refers to healthcare associated infections (HAI) stands as a one of the major global healthcare concerns since it comprises ∼10 % of all admitted patients with a ∼1 % mortality rate and a ∼3 % mortality contribution to other diseases, amounting to millions of unnecessary death... |
10. 1002/cphc. 202100276 | 2,021 | Chemphyschem | Gelation Kinetics‐Structure Analysis of pH‐triggered Low Molecular Weight Hydrogelators | Abstract Properties such as shear modulus, gelation time, structure of supramolecular hydrogels are strongly dependent on self‐assembly, gelation triggering mechanism and processes used to form the gel. In our work we extend reported rheology analysis methodologies to pH‐triggered supramolecular gels to understand stru... | 1 Introduction Supramolecular gels formed by the self‐assembly of low molecular weight hydrogelators (LMWGs) are an important class of supramolecular materials. With applications ranging from cell culture scaffolds, drug delivery systems, they are emerging as an alternative to their polymer counterparts. [ 1, 2 ] A num... |
10. 1002/cphc. 202100570 | 2,021 | Chemphyschem | Fluorescence Emission of Self‐assembling Amyloid‐like Peptides: Solution versus Solid State | Abstract Analysis of the intrinsic UV‐visible fluorescence exhibited by self‐assembling amyloid‐like peptides in solution and in solid the state highlights that their physical state has a profound impact on the optical properties. In the solid state, a linear dependence of the fluorescence emission peaks as a function ... | 1 Introduction Non‐covalent interactions play major roles in the activity of biomolecules as they dictate most of their physiological/pathological partnerships and oligomerizations. One of the areas in which non‐covalent interactions provide a crucial contribution is the amyloid‐like aggregation exhibited by an uncount... |
10. 1002/cphy. c180037 | 2,020 | Comprehensive Physiology | Tissue Engineering of the Microvasculature | The ability of generate new microvessels in desired numbers and at desired locations has been a long-sought goal in vascular medicine, engineering, and biology. Historically, the need to revascularize ischemic tissues non-surgically (so-called therapeutic vascularization) served as the main driving force for the develo... | No full text available |
10. 1002/cpsc. 41 | 2,019 | Current protocols in stem cell biology | Human Adipose-Derived Stromal Cell Isolation Methods and Use in Osteogenic and Adipogenic | Adipose tissue represents an abundant and easily accessible source of multipotent cells, which may serve as excellent building blocks for tissue engineering. This article presents a newly described protocol for isolating adipose-derived stromal cells (ASCs) from human lipoaspirate, compared to the standard protocol for... | No full text available |
10. 1002/cpt. 2627 | 2,022 | Clinical Pharmacology and Therapeutics | New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium | Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state‐of‐the‐art article is to describe recent advances in research on membrane transporters that are particularly relevant to drug discovery and development. This review covers advances in bas... | For over a decade the International Transporter Consortium (ITC) has co‐authored important review and position papers that are relevant to transporters in drug development, focusing largely on drug–drug interactions (DDIs), but also including other topics relevant to the role of transporters in drug absorption, distrib... |
10. 1002/cre2. 187 | 2,019 | Clinical and Experimental Dental Research | Who can claim the ownership to the blueprints of my body parts? | No abstract available | Advances in computer‐assisted design and manufacturing (CAD‐CAM) technologies enable the fabrication of individualised biomimetic body parts for an increasing range of damaged tissues and organs. CAD‐CAM in dentistry evolved 30 years ago for making intracoronal ceramic restorations, whereas the predominating CAD‐CAM–ba... |
10. 1002/cre2. 221 | 2,019 | Clinical and Experimental Dental Research | Strontium enhances proliferation and osteogenic behavior of bone marrow stromal cells of mesenchymal and ectomesenchymal origins in vitro | Abstract Obejective To investigate the effect of increasing Strontium (Sr) concentrations on the growth and osteogenic behavior of human bone marrow stromal cells (BMSCs) from mesenchymal (i. e. , fibula) and ectomesenchymal (i. e. , mandible) embryonic origins. Materials and methods Fibula and mandible BMSCs were cult... | 1 INTRODUCTION Bone marrow stromal cells (BMSCs) have been suggested as a suitable cellular source for bone tissue engineering therapies (Dayi & Omezli, 2011 ). However, these cell populations have a heterogeneous nature, which is evident from the broad range of colony sizes, varying growth rates, and different cell mo... |
10. 1002/cre2. 414 | 2,021 | Clinical and Experimental Dental Research | Comparative barrier membrane degradation over time: Pericardium versus dermal membranes | Abstract Objective The effectiveness of GBR procedures for the reconstruction of periodontal defects has been well documented. The objective of this investigation was to evaluate the degradation kinetics and biocompatibility of two resorbable collagen membranes in conjunction with a bovine xenograft material. Materials... | 1 INTRODUCTION The treatment protocol of isolating a defect site in an effort to improve tissue healing and guided regeneration of native tissue utilizing a mechanical barrier has been extensively explored in reconstructive surgery, prior to the development of dental implants in the 1950s (Bassett, Campbell, Girado, Ro... |
10. 1002/cre2. 423 | 2,021 | Clinical and Experimental Dental Research | The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to | Abstract Objectives Transplantation of stem cells into wounds has become popular in regeneration therapies. As stem cells for transplantation, human dental pulp stem cells (hDPSCs) are known to be pluripotent cells that are relatively easy to collect from the pulp of deciduous or wisdom teeth. The purpose of this study... | 1 INTRODUCTION The secretion of saliva is related to swallowing, pronunciation, lubrication, antibacterial action, buffering action, taste, and so on (Carlson & Ord, 2008 ; Vissink, Burlage, Spipijkervet, Jansma, & Coppes, 2003 ; Vissink, Jansma, Spijkervet, Burlage, & Coppes, 2003 ). Salivary glands that secrete saliv... |
10. 1002/cre2. 563 | 2,022 | Clinical and Experimental Dental Research | Effects of advanced platelet‐rich fibrin combined with xenogenic bone on human periodontal ligament stem cells | Abstract Objectives In this study, we aimed to investigate the effects of a mixture of advanced platelet‐rich fibrin (A‐PRF) and xenogenic bone substitute material (XBSM) on the proliferation and migration of human periodontal ligament stem cells (hPDLSCs) based on the in vitro release of growth factors. Material and M... | 1 INTRODUCTION Periodontitis is a multifactorial chronic infection caused by a myriad of bacterial species that interact with the host's tissues and cells, which causes the release of a series of cytokines, chemokines, and inflammatory mediators. These activities result in the destruction of the periodontal tissue stru... |
10. 1002/cre2. 695 | 2,023 | Clinical and Experimental Dental Research | Regulatory mechanisms of GCN5 in osteogenic differentiation of MSCs in periodontitis | Abstract Objectives The regulatory mechanisms of GCN5 (General control non‐repressed protein5) in the osteogenic differentiation of mesenchymal stem cells (MSCs) in periodontitis are still unclear. The purpose of this review focuses on the regulating roles of GCN5 in bone metabolism and periodontitis, discusses the pot... | 1 INTRODUCTION Periodontitis is a kind of chronic inflammatory disease characterized by inflammation of the periodontal tissue and resorption of the alveolar bone. Periodontitis has been the primary cause of tooth loss because of its ability to cause continuous and irreversible destruction of periodontal tissue (Engebr... |
10. 1002/cre2. 71 | 2,017 | Clinical and Experimental Dental Research | Synergistic effects of the combined use of human‐cultured periosteal sheets and platelet‐rich fibrin on bone regeneration: An animal study | Abstract A human‐cultured alveolar bone‐derived periosteal (hCP) sheet is an osteogenic grafting material used clinically in periodontal regenerative therapy, while platelet‐rich fibrin (PRF), a platelet concentrate with fibrin clot, is considered to augment the wound healing process. Therefore, whether the combined us... | 1 INTRODUCTION Periodontal and alveolar bone regenerative therapies have been developed from bone grafting, guided tissue/bone regeneration, enamel matrix derivatives, and their use in combined therapies (Koop et al, 2012 ). In the last few decades, cell‐based grafting materials have been applied to bone regenerative t... |
10. 1002/cre2. 816 | 2,023 | Clinical and Experimental Dental Research | Effect of pulp capping materials on odontogenic differentiation of human dental pulp stem cells: An in vitro study | Abstract Objectives Migration and differentiation of human dental pulp stem cells (hDPSCs) is a vital and key factor in the success of reparative dentin formation for maintenance of pulp vitality. Pulp capping materials are used to stimulate DPSCs to induce new dentin formation. Thus, the aim of the present study was t... | 1 INTRODUCTION Maintenance of pulp vitality in restorative procedures has become increasingly feasible due to emerging advanced treatments (Nakashima & Akamine, 2005 ; Qureshi et al. , 2014 ; Sharaan et al. , 2021 ). Direct pulp capping is a vital pulp therapy for a pin‐point dental pulp exposure when there is no infla... |
10. 1002/cre2. 875 | 2,024 | Clinical and Experimental Dental Research | Comparing the effects of Bone | Abstract Background The bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore,... | 1 INTRODUCTION There is a common occurrence in which patients lack sufficient bone support to fully support implants when placed. Bone regeneration therapy is usually administered before or concurrently with implant insertion. Reconstruction and augmentation of skeletally damaged areas through bone grafting can be acco... |
10. 1002/cssc. 201501697 | 2,016 | Chemsuschem | Nanostructurally Controlled Hydrogel Based on Small‐Diameter Native Chitin Nanofibers: Preparation, Structure, and Properties | Abstract Chitin nanofibers of unique structure and properties can be obtained from crustacean and fishery waste. These chitin nanofibers have roughly 4 nm diameters, aspect ratios between 25–250, a high degree of acetylation and preserved crystallinity, and can be potentially applied in hydrogels. Hydrogels with a chit... | Introduction Materials from renewable resources have the potential to be more environmentally friendly than polymer materials of petrochemical origin. 1 The annual production of chitin in nature is estimated to be in the range of 10–100 trillion tones, and the seafood industry generates large amount of chitin waste. 2 ... |
10. 1002/cssc. 201802383 | 2,019 | Chemsuschem | Atomic Force Microscopy Meets Biophysics, Bioengineering, Chemistry, and Materials Science | Abstract Briefly, herein the use of atomic force microscopy (AFM) in the characterization of molecules and (bioengineered) materials related to chemistry, materials science, chemical engineering, and environmental science and biotechnology is reviewed. First, the basic operations of standard AFM, Kelvin probe force mic... | 1 Introduction According to Web of Science, 104 522 items are associated with the term “atomic force microscopy” (AFM) since 1987 (search carried out in December 2018). This large number shows that AFM is well established in the scientific community. After refining the search, the number of items related to both scient... |
10. 1002/cssc. 202100400 | 2,021 | Chemsuschem | The Chemical Recycling of Polyesters for a Circular Plastics Economy: Challenges and Emerging Opportunities | Abstract Whilst plastics have played an instrumental role in human development, growing environmental concerns have led to increasing public scrutiny and demands for outright bans. This has stimulated considerable research into renewable alternatives, and more recently, the development of alternative waste management s... | 1 Introduction Plastics have played a crucial role in human development since their commercialisation in the 20th century, revolutionising key sectors such as transport, communications and healthcare. Whilst their inherent strength and durability is revered during their functional lifetime, such properties render plast... |
10. 1002/cssc. 202100909 | 2,021 | Chemsuschem | Chemo‐Biological Upcycling of Poly(ethylene terephthalate) to Multifunctional Coating Materials | Abstract Chemo‐biological upcycling of poly(ethylene terephthalate) (PET) developed in this study includes the following key steps: chemo‐enzymatic PET depolymerization, biotransformation of terephthalic acid (TPA) into catechol, and its application as a coating agent. Monomeric units were first produced through PET gl... | Introduction Over 360 million tons of plastics are produced annually worldwide; [1a] however, the recycling rate accounts for only less than 9 % of the produced plastics because the value of recycled plastics is relatively low due to poor properties. [1b] Plastic wastes are hardly recycled, and most of them ends up in ... |
10. 1002/ctm2. 1094 | 2,022 | Clinical and Translational Medicine | Anti‐inflammatory hydrogel dressings and skin wound healing | Abstract Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐inflammatory function of hydrogel dressings has been significantly improved, addressing many clinical challenges presented in ongoing endeavours to promote wound healing. Wound healing is a cascaded and highly comple... | 1 INTRODUCTION As one of the most important organs of the human body, which protects us from harsh external environments, the skin is often damaged by traumas, severe burns, ulcers and various other injuries, thus disrupting its protective barrier functions and vital role in sensory perception. In addition, such injuri... |
10. 1002/ctm2. 1112 | 2,022 | Clinical and Translational Medicine | Differences in the intrinsic chondrogenic potential of human mesenchymal stromal cells and iPSC‐derived multipotent cells | Abstract Background Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem cells (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance transforming growth factor‐β (TGFβ)‐induced hiMPC chondrogenesis. In contr... | 1 INTRODUCTION Due to the limited self‐repairing capacity of hyaline cartilage, chondral defects often require osteochondral transplantation or cell implantation to support the regeneration process. 1 Autologous chondrocyte implantation (ACI), which involves the isolation, expansion and implantation of autologous chond... |
10. 1002/ctm2. 1499 | 2,023 | Clinical and Translational Medicine | Organoid assessment technologies | Abstract Despite enormous advances in the generation of organoids, robust and stable protocols of organoids are still a major challenge to researchers. Research for assessing structures of organoids and the evaluations of their functions on in vitro or in vivo is often limited by precision strategies. A growing interes... | 1 INTRODUCTION The term ‘organoid’ has been used to define complex three‐dimensional (3D) structures, which displays similar architectures and functionalities to in vivo organs. 1 Now, a more restricted definition encompasses organoids generated from primary tissues or stem cells, serving as in vitro platforms to mimic... |
10. 1002/ctm2. 1656 | 2,024 | Clinical and Translational Medicine | Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy | Abstract Background Organoid technology is an emerging and rapidly growing field that shows promise in studying organ development and screening therapeutic regimens. Although organoids have been proposed for a decade, concerns exist, including batch‐to‐batch variations, lack of the native microenvironment and clinical ... | 1 ORGANOID AND ASSEMBLOID TECHNOLOGY Organoids have been emerging models in the last decade for studying organ development and prediction of clinical treatment regimens. One of the crucial capabilities in organoid technology is the development of the microstructure and microenvironment of the particular organ. 1 Given ... |
10. 1002/ctm2. 227 | 2,020 | Clinical and Translational Medicine | Long noncoding RNA repressor of adipogenesis negatively regulates the adipogenic differentiation of mesenchymal stem cells through the hnRNP A1‐PTX3‐ERK axis | Abstract Background Mesenchymal stem cells (MSCs) are pluripotent stem cells that can differentiate via osteogenesis and adipogenesis. The mechanism underlying MSC lineage commitment still remains incompletely elucidated. Understanding the regulatory mechanism of MSC differentiation will help researchers induce MSCs to... | LIST OF ABBREVIATIONS C/EBP‐α CCAAT/enhancer binding protein alpha ChIP chromatin immunoprecipitation ERK extracellular signal‐regulated kinase FABP4 fatty acid binding protein 4 H&E staining hematoxylin and eosin staining hnRNP A1 heterogeneous ribonucleoprotein A1 IGFBP2 insulin‐like growth factor binding protein 2 l... |
10. 1002/ctm2. 413 | 2,021 | Clinical and Translational Medicine | A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype | No abstract available | To the Editor: Brugada syndrome (BrS) is an inherited arrhythmic disease predisposing to sudden cardiac death (SCD), characterized by a typical electrocardiogram pattern that includes a J point elevation with a coved type ST segment. 1 BrS is a complex genetic disease in which ∼20% of patients carry rare variants in SC... |
10. 1002/ctm2. 566 | 2,021 | Clinical and Translational Medicine | Cholangiocyte organoids from human bile retain a local phenotype and can repopulate bile ducts in vitro | Abstract The well‐established 3D organoid culture method enabled efficient expansion of cholangiocyte‐like cells from intrahepatic (IHBD) and extrahepatic bile duct (EHBD) tissue biopsies. The extensive expansion capacity of these organoids enables various applications, from cholangiocyte disease modelling to bile duct... | 1 INTRODUCTION The biliary tree is a complex tubular system representing the extrahepatic bile duct (EHBD) and the intrahepatic bile duct (IHBD). 1 In addition to the difference in anatomical location, both these ductal structures originate from distinct progenitor cells during embryogenic development. 2 The IHBD arise... |
10. 1002/ctm2. 650 | 2,021 | Clinical and Translational Medicine | Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity | Abstract Background The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood, thus limiting clinical application and basic research reproducibility. Advanced single‐cell RNA sequencing (scRNA‐seq) is a robust tool used to analyse for dissecting cellular heterogeneity. However, the comprehensive single‐ce... | 1 INTRODUCTION Tissue engineering and regenerative medicines utilising mesenchymal stem cells (MSCs) are considered promising for clinical applications in various diseases. 1 However, substantial batch‐to‐batch variations in phenotypes and functions have limited consensus, thus hampering the efficiency and reproducibil... |
10. 1002/ctm2. 690 | 2,022 | Clinical and Translational Medicine | Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials | Abstract Bone tissue engineering is a rapidly developing field with potential for the regeneration of craniomaxillofacial (CMF) bones, with 3D printing being a suitable fabrication tool for patient‐specific implants. The CMF region includes a variety of different bones with distinct functions. The clinical implementati... | 1 INTRODUCTION Reconstruction of bone defects of the cranio‐maxillofacial (CMF) region, such as large segmental mandibular defects resulting from trauma, tumour excision, infections or congenital deformities, is a major surgical intervention. To date, transplantation of an autologous bone graft is the standard of care ... |
10. 1002/ctm2. 95 | 2,020 | Clinical and Translational Medicine | Conditional reprogramming: Modeling urological cancer and translation to clinics | Abstract Patient‐derived models, including cell models (organoids and conditionally reprogrammed cells [CRCs]) and patient‐derived xenografts, are urgently needed for both basic and translational cancer research. Conditional reprogramming (CR) technique refers to a co‐culture system of primary human normal or tumor cel... | Abbreviations 3D three‐dimensional ALP alkaline phosphatase BCa bladder cancer CR conditional reprogramming CRCs conditionally reprogrammed cells CTCs circulating tumor cells CYPs cytochromes p450 Dkk1 dickkopf‐related protein 1 ESCs embryonic stem cells iPSCs induced pluripotent stem cells PCa prostate cancer PDMs pat... |
10. 1002/cyto. a. 22680 | 2,015 | Cytometry | A 3D | Abstract Harnessing mesenchymal stem cells for tissue repair underpins regenerative medicine. However, how the 3D tissue matrix maintains such cells in a quiescent state whilst at the same time primed to respond to tissue damage remains relatively unknown. Developing more physiologically relevant 3D models would allow ... | Mesenchymal stem cells (MSCs), multi‐potent cells from which connective tissues arise, are currently the focus of intense scientific interest from the standpoint of regenerative medicine and tissue engineering. Harnessing the MSC population to initiate repair has wide ranging implications in many tissue types, includin... |
10. 1002/deo2. 81 | 2,021 | DEN Open | Single operator experience of endoscopic submucosal dissection for Barrett's neoplasia in a North American academic center | Abstract Objectives Endoscopic submucosal dissection (ESD) is carving out an increasing role in the treatment of Barrett's associated neoplasia. ESD provides the advantage of en‐bloc resections and greater R0 resection rates. We aim to present outcomes from one of the largest single‐center cohorts of esophageal ESD in ... | BACKGROUND Endoscopic submucosal dissection (ESD) is an endoscopic technique that allows for en‐bloc resection of larger lesions to facilitate pathologic examination. Esophageal ESD was first performed in the esophagus in Japan for the treatment of squamous cell carcinoma (SCC). 1 However, the western landscape of esop... |
10. 1002/dvdy. 24281 | 2,015 | Developmental dynamics : an official publication of the American Association of Anatomists | Deciphering principles of morphogenesis from temporal and spatial patterns on the integument | How tissue patterns form in development and regeneration is a fundamental issue remaining to be fully understood. The integument often forms repetitive units in space (periodic patterning) and time (cyclic renewal), such as feathers and hairs. Integument patterns are visible and experimentally manipulatable, helping us... | No full text available |
10. 1002/dvg. 23490 | 2,022 | Genesis (New York, N. y. : 2000) | Roles of osteoclasts in alveolar bone remodeling | Summary Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone formation is critical to maintain bone homeostasis. The alveolar bone, also called the alveolar process, is the part of the jawbone t... | 1 INTRODUCTION Our skeletal system includes more than 200 bones which provide a rigid framework to support the body and serve as a reservoir of calcium. The jawbone is morphologically and functionally different from other skeletal bones. It is originated from migrating cranial neural crest cells and forms through prima... |
10. 1002/dvg. 23499 | 2,022 | Genesis (New York, N. y. : 2000) | Novel approaches for periodontal tissue engineering | Summary The periodontal complex involves the hard and soft tissues which support dentition, comprised of cementum, bone, and the periodontal ligament (PDL). Periodontitis, a prevalent infectious disease of the periodontium, threatens the integrity of these tissues and causes irreversible damage. Periodontal therapy aim... | 1 INTRODUCTION TO REGENERATIVE MEDICINE IN PERIODONTOLOGY The periodontal complex involves the hard and soft tissues which support dentition. Given its significant roles in force transduction, providing sensory information about tooth position, facilitating jaw reflexes during tooth movement, and resistance to mechanic... |
10. 1002/dvg. 23501 | 2,022 | Genesis (New York, N. y. : 2000) | Advanced biomaterials for periodontal tissue regeneration | Summary The periodontium is a suitable target for regenerative intervention, since it does not functionally restore itself after disease. Importantly, the limited regeneration capacity of the periodontium could be improved with the development of novel biomaterials and therapeutic strategies. Of note, the regenerative ... | 1 INTRODUCTION Periodontal disease (PD) is one of the most destructive inflammatory oral disorders, affecting roughly 45% of the adult population in the United States (Eke et al. , 2015 ). This chronic inflammatory disease is defined by the slow degradation and loss of alveolar bone and other periodontal tissues (i. e.... |
10. 1002/ehf2. 13256 | 2,021 | ESC Heart Failure | Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies | Abstract The concept that cell‐based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further ... | Introduction Research on myocardial repair and regeneration has substantially contributed to a better understanding of cardiomyocyte biology 1 ; however, cardiovascular reparative medicine has been criticized in part due to modest effects in clinical trials and the perception that translation to clinically effective ap... |
10. 1002/ejhf. 2414 | 2,022 | European Journal of Heart Failure | Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC) | Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins. Clinical phenotypes such as heart failure and arrhythmia are classically treated with generic drugs, but aetiology‐specific and targeted treatmen... | Introduction Cardiomyopathies form a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Comprehensive understanding of the underlying mechanisms and natural courses have led to recent therapeutic advances with far‐reaching impact on management and prognosis. 1 Amongst the cardiom... |
10. 1002/eji. 202048769 | 2,021 | European Journal of Immunology | Multiomics uncovers developing immunological lineages in human | Abstract The development of the human immune system during embryonic and fetal life has historically been difficult to research due to limited access to human tissue. Experimental animal models have been widely used to study development but cellular and molecular programmes may not be conserved across species. The adve... | Introduction A brief history of single‐cell multiomics Single‐cell technologies are often regarded as recently developed approaches for studying cellular biology, however, we have had the ability to evaluate individual cells for centuries. During the 1800s, and with the help of the invention of the microscope, scientis... |
10. 1002/ejic. 201801077 | 2,018 | European Journal of Inorganic Chemistry | Stimuli‐Responsive Phosphorus‐Based Polymers | This microreview details recent developments in stimuli‐responsive polymers with phosphorus in the main‐chain, in particular polyphosphazenes and polyphosphoesters. The presence of phosphorus in the polymers endows unique properties onto the macromolecules, which can be utilized for the preparation of materials capable... | 1. Introduction While the importance of polymers both as commodity and as high‐performance materials is long established, in recent decades a better fundamental understanding of structure property relationships has been combined with vast improvements in controlled polymerization methods. This has allowed for the prepa... |
10. 1002/elps. 202000156 | 2,020 | Electrophoresis | Dielectrophoresis: Developments and applications from 2010 to 2020 | Abstract The 20th century has seen tremendous innovation of dielectrophoresis (DEP) technologies, with applications being developed in areas ranging from industrial processing to micro‐ and nanoscale biotechnology. From 2010 to present day, there have been 981 publications about DEP. Of over 2600 DEP patents held by th... | Abbreviations AC alternating current AFM atomic force microscopy BPD benign pancreatic disease cDEP contactless DEP CTC circulating tumor cell DENV dengue virus GFAP glial fibrillary acidic protein DC direct current DEP dielectrophoresis EV extracellular vesicles fDEP fluidic DEP iDEP insulator‐based DEP ITO indium tin... |
10. 1002/elsc. 201600084 | 2,016 | Engineering in Life Sciences | A porous medium‐chain‐length poly(3‐hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering | Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of medium‐chain‐length poly(3‐hydroxyalkanoates) (mcl‐PHA) and hydroxyapatite (HA) was fabricated ... | No full text available |
10. 1002/elsc. 201900009 | 2,019 | Engineering in Life Sciences | Preparation of electrospun polycaprolactone nanofiber mats loaded with microalgal extracts | Abstract Sustainable, ecological, and biocompatible materials are emerging for the development of novel components for tissue engineering. Microalgae being one of the unique organisms on Earth to provide various novel compounds with certain bioactivities are also a good source for the development of novel tissue scaffo... | No full text available |
10. 1002/elsc. 201900105 | 2,019 | Engineering in Life Sciences | Thiol‐ene photoclick reaction: An eco‐friendly and facile approach for preparation of MPEG‐g‐keratin biomaterial | Abstract Wool keratin is a natural material with excellent properties, which is considered as scaffold biomaterial for tissue engineering. Polyethylene glycol can improve the mechanical properties of keratin materials because of its excellent biocompatibility and plasticity. In the present work, poly (ethylene glycol) ... | Abbreviations ANS 8‐anilino‐1‐naphthalenesulfonic acid ammonium salt CD circular dichroism DLS dynamic light scattering HMPP 2‐hydroxy‐2‐methylpropiophenone MPEGMA poly (ethylene glycol) methyl ether methacrylate PEG polyethylene glycol XRD X‐ray diffraction 1 INTRODUCTION Keratin is a renewable resource, which is wide... |
10. 1002/elsc. 202000003 | 2,020 | Engineering in Life Sciences | Tissue engineering in female pelvic floor reconstruction | Abstract Pelvic organ prolapse is a common and frequently occurring disease in middle‐aged and elderly women. Mesh implantation is an ideal surgical treatment. The polypropylene mesh commonly used in clinical practice has good mechanical properties, but there are long‐term complications. The application of tissue engin... | Abbreviations PFD pelvic floor dysfunction POP pelvic organ prolapse 1 INTRODUCTION Pelvic organ prolapse (POP) is a common debilitating condition affecting about 30–40% of women. POP is the herniation of pelvic organs into the vagina with symptoms of bladder, bowel, and sexual dysfunction [ 1 ]. The POP etiology is mu... |
10. 1002/elsc. 202000072 | 2,021 | Engineering in Life Sciences | null | Abstract In this study, the biocatalytic performance of a Baeyer‐Villiger monooxygenase (BVMO) catalyzing the reaction of cyclohexanone to ε‐caprolactone was investigated in Pseudomonas biofilms. Biofilm growth and development of two Pseudomonas taiwanensis VLB120 variants, Ps_BVMO and Ps_BVMO_DGC, were evaluated in dr... | Abbreviations 6OH 6‐hydroxyhexanoic acid Aa adipic acid. BDW biofilm dry weight BVMO Baeyer‐Villiger monooxygenase CDW cell dry weight CHOL cyclohexanol CHON cyclohexanone CL ɛ‐caprolactone DFR drip flow reactor DGC diguanylate cyclase RBBR rotating bed biofilm reactor RBR rotating bed reactor 1 INTRODUCTION The Baeyer... |
10. 1002/elsc. 202100020 | 2,021 | Engineering in Life Sciences | A novel model to culture cells from giant cell tumor of bone using three‐dimensional (3D) polycaprolactone scaffold | Abstract Two‐dimensional (2D) culture of cells from giant cell tumor of bone (GCTB) is affected by loss of the multinucleated giant cells in subsequent passages. Therefore, there is limited time to study GCTB with all its histological components in 2D culture. Here, we explored the possibility of culturing GCTB cells o... | Abbreviations GCTB giant cell tumor of bone 2D two dimensional 3D three dimensional PCL polycaprolactone Giant Cell Tumor of Bone (GCTB) is a primary bone tumor and is classified as an intermediate, locally aggressive, but rarely metastasizing tumor. GCTB comprises three types of cells: (1) multinucleated osteoclast‐ty... |
10. 1002/elsc. 202100034 | 2,021 | Engineering in Life Sciences | Patterned vascularization in a directional ice‐templated scaffold of decellularized matrix | Abstract Vascularization is fundamental for large‐scale tissue engineering. Most of the current vascularization strategies including microfluidics and three‐dimensional (3D) printing aim to precisely fabricate microchannels for individual microvessels. However, few studies have examined the remodeling capacity of the m... | Abbreviation ECM extracellular matrix 1 INTRODUCTION Vascularization is fundamental for engineering artificial organs, as microvessels are required to transport nutrients and oxygen to the cells inside large‐scale tissues [ 1 ]. Various strategies have been developed to culture microvessels in vitro [ 2, 3 ]. One commo... |
10. 1002/elsc. 202100040 | 2,021 | Engineering in Life Sciences | The pro‐inflammatory response of macrophages regulated by acid degradation products of poly(lactide‐co‐glycolide) nanoparticles | Abstract Poly(lactide‐co‐glycolide) (PLGA) shows great potentials in biomedical applications, in particular with the field of biodegradable implants and control release technologies. However, there are few systematic and detailed studies on the influence of PLGA degradation behavior on the immunogenicity. In this study... | 1 INTRODUCTION In recent decades, biodegradable polymers are employed in a variety of medical applications, e. g. carrier for drug delivery system, equipment for orthopedic surgery, stent for tissue engineering, etc. [ 1, 2, 3 ]. Biodegradable polymers presently used as tissue engineering scaffolds can be grouped into ... |
10. 1002/elsc. 202100081 | 2,021 | Engineering in Life Sciences | 3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics | Abstract Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the additive manufacturing of diverse objects and tools, using various materials. The relative flexibility, straightforwardness, and ability to enable rapid prototyping are tremendous advantages offered by this technique c... | Abbreviations CAD computer‐aided design DLP digital light processing FDM fused deposition modeling MJP MultiJet printing OD optical density PDMS polydimethylsiloxane PSi porous silicon S. cerevisiae Saccharomyces cerevisiae SLA stereolithography SPE screen printed electrode 1 INTRODUCTION In recent years, additive manu... |
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