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10. 1002/btm2. 10139 | 2,019 | Bioengineering & Translational Medicine | Engineering tissue‐specific blood vessels | Abstract Vascular diversity among organs has recently become widely recognized. Several studies using mouse and human fetal tissues revealed distinct characteristics of organ‐specific vasculature in molecular and functional levels. Thorough understanding of vascular heterogeneities in human adult tissues is significant... | 1 INTRODUCTION Vasculature connects all organs in the body and allows for the systemic interaction of the organs through soluble factors, nutrients, and cells. It is widely appreciated now that vasculature does not only function as a transport barrier or conduit, but it also regulates the homeostasis and tissue regener... |
10. 1002/btm2. 10142 | 2,019 | Bioengineering & Translational Medicine | Phage display as a tool for vaccine and immunotherapy development | Abstract Bacteriophages, or phages, are viruses that specifically infect bacteria and coopt the cellular machinery to create more phage proteins, eventually resulting in the release of new phage particles. Phages are heavily utilized in bioengineering for applications ranging from tissue engineering scaffolds to immune... | 1 INTRODUCTION Bacteriophages, or phages, are prokaryotic viruses that specifically infect bacteria, and are the most abundant life form on earth. 1 Phages were first discovered in the early 20th century and noted for their antibacterial activity. The practice of administering phages (i. e. , phage therapy) to patients... |
10. 1002/btm2. 10155 | 2,020 | Bioengineering & Translational Medicine | Introduction to Editorial Board Member: Professor Antonios (Tony) G. Mikos | No abstract available | In this issue of Bioengineering and Translational Medicine, I am excited to introduce the Editorial Board Member, Prof. Antonios (Tony) G. Mikos. Prof. Mikos is the Louis Calder Professor of Bioengineering, Chemical and Biomolecular Engineering, and Director of the National Institutes of Health Center for Engineering C... |
10. 1002/btm2. 10158 | 2,020 | Bioengineering & Translational Medicine | Hydrogels in the clinic | Abstract Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels’ versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, an... | 1 INTRODUCTION Hydrogels are crosslinked hydrophilic polymer networks of high‐water content. Due to this high water content, hydrogels exhibit favorable biocompatibility and as such have been developed for and used in a variety of medical applications. 1, 2, 3 Since hydrogel properties can be tuned through a variety of... |
10. 1002/btm2. 10162 | 2,020 | Bioengineering & Translational Medicine | Introduction to Editorial Board Member: Professor David J. Mooney | No abstract available | In this issue of Bioengineering and Translational Medicine, we are pleased to introduce our Editorial Board Member, Professor David J. Mooney (Figure 1 ). Professor Mooney is the Robert P. Pinkas Family Professor of Bioengineering at the John A. Paulson School of Engineering and Applied Sciences at Harvard University. ... |
10. 1002/btm2. 10174 | 2,020 | Bioengineering & Translational Medicine | Introduction to Editorial Board Member: Professor W. Mark Saltzman | No abstract available | In this issue of Bioengineering and Translational Medicine, we are pleased to introduce our Editorial Board Member, Professor W. Mark Saltzman. Professor Saltzman is the Goizueta Foundation Professor of Biomedical Engineering, Chemical and Environmental Engineering, and Physiology at Yale University. Professor Saltzman... |
10. 1002/btm2. 10178 | 2,020 | Bioengineering & Translational Medicine | null | No abstract available | 2020 marks an important year in the evolution of BioTM. We received our first impact factor of 6. 091 this year. This is a massive accomplishment for all stakeholders of the journal. The journal was formally launched in 2015 and we published our first issue in 2016. Within a short period of 4 years, we were able to rea... |
10. 1002/btm2. 10180 | 2,020 | Bioengineering & Translational Medicine | In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering | Abstract Converting biopolymers to extracellular matrix (ECM)‐mimetic hydrogel‐based scaffolds has provided invaluable opportunities to design in vitro models of tissues/diseases and develop regenerative therapies for damaged tissues. Among biopolymers, gelatin and its crosslinkable derivatives, such as gelatin methacr... | 1 INTRODUCTION Hydrogels sourced from natural and/or synthetic materials have leveraged technologies pertinent to water treatment, energy storage, food security, and healthcare. 1, 2, 3, 4, 5, 6, 7 Granular hydrogel scaffolds have introduced emerging opportunities for developing in vitro tissue/disease models as well a... |
10. 1002/btm2. 10185 | 2,020 | Bioengineering & Translational Medicine | null | No abstract available | No one can predict the future, but that is not going to stop us from taking a shot at it. At BioTM, we do wonder what the future holds for our key scientific areas, including drug delivery, tissue engineering, cell therapy, and biosensors, among many others. Ultimately, the future will become what the future scientists... |
10. 1002/btm2. 10190 | 2,020 | Bioengineering & Translational Medicine | Magnetic microgels and nanogels: Physical mechanisms and biomedical applications | Abstract Soft micro‐ and nanostructures have been extensively developed for biomedical applications. The main focus has been on multifunctional composite materials that combine the advantages of hydrogels and colloidal particles. Magnetic microgels and nanogels can be realized by hybridizing stimuli‐sensitive gels and ... | Abbreviations BMP‐2 bone morphogenetic protein 2 LCST lower critical solution temperature MG microgel miRNA microRNA MMG magnetic microgel MNG magnetic nanogel MNP magnetic nanoparticle MPI magnetic particle imaging MRI magnetic resonance imaging NG nanogel NIPAM N ‐isopropyl acrylamide NP nanoparticle PEG poly(ethylen... |
10. 1002/btm2. 10192 | 2,020 | Bioengineering & Translational Medicine | Validation of the 1, | Abstract Tissue engineering (TE) seeks to fabricate implants that mimic the mechanical strength, structure, and composition of native tissues. Cartilage TE requires the development of functional personalized implants with cartilage‐like mechanical properties capable of sustaining high load‐bearing environments to integ... | Abbreviations b‐TPUe 1, 4‐butanediol thermoplastic polyurethane CAD computer‐aided design CAM computer‐aided manufacturing DMMB dimethylmethylene blue ECM extracellular matrix ESEM environmental scanning electron microscope FBS fetal bovine serum GAGs glycosaminoglycans ITS insulin‐transferrin‐selenium MSCs mesenchymal... |
10. 1002/btm2. 10206 | 2,020 | Bioengineering & Translational Medicine | A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy | Abstract In clinical terms, bone grafting currently involves the application of autogenous, allogeneic, or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as polymers, bioceramics, and other composites. Many of these are associated with limitations. The ideal scaffold for bone tis... | 1 INTRODUCTION Despite the promising prospect of cell treatments for tissue engineering, the general application of engineered tissue and stem cells has not yet achieved clinical reality. Many details, including the selection, delivery, viability, and phenotypic stability of the cells, in addition to time‐consuming the... |
10. 1002/btm2. 10214 | 2,021 | Bioengineering & Translational Medicine | Cell therapies in the clinic | Abstract Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics. Particularly, living cells can simultaneo... | 1 INTRODUCTION Cell therapies represent a major frontier and paradigm shift in biotechnology. In contrast to conventional therapeutic modalities, cell therapies are living and can dynamically respond to biological cues to attack malignancies, regenerate tissues, restore impaired or lost biological functions, or otherwi... |
10. 1002/btm2. 10216 | 2,021 | Bioengineering & Translational Medicine | Non‐invasive in vivo monitoring of transplanted stem cells in | Abstract Cell‐based tissue engineering strategies have been widely established. However, the contributions of the transplanted cells within the tissue‐engineered scaffolds to the process of tissue regeneration remain poorly understood. Near‐infrared (NIR) fluorescence imaging systems have great potential to non‐invasiv... | 1 INTRODUCTION Tissue engineering involves the combination of cells with natural or synthetic biomaterials to create implantable tissue constructs, and it offers an attractive approach for the treatment of damaged tissues and organs. A large number of successful tissue engineering strategies require the use of mesenchy... |
10. 1002/btm2. 10221 | 2,021 | Bioengineering & Translational Medicine | Silk fibroin and ceramic scaffolds: Comparative in vitro studies for bone regeneration | Abstract Synthetic bone void fillers based on calcium ceramics are used to fill cavities in the bone and promote bone regeneration. More recently, silk fibroin (SF), a protein polymer obtained from Bombyx mori silkworm, has emerged as a promising material in bone void filling. In this work, we have compared the safety ... | List of Abbreviations ALP alkaline phosphatase β‐TCP beta tricalcium phosphate BMP bone morphogenic protein CaSO 4 calcium sulphate DMSO dimethyl sulphoxide HA hydroxyapatite HDPE high‐density polyethylene hMSC human mesenchymal stem cells IL‐1β interleukin 1 beta LPS lipopolysaccharide L‐RSF lyophilized‐regenerated si... |
10. 1002/btm2. 10223 | 2,021 | Bioengineering & Translational Medicine | Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes | Abstract Nerve guidance conduits (NGCs) are used as an alternative to the “gold standard” nerve autografting, preventing the need for surgical intervention required to harvest autologous nerves. However, the regeneration outcomes achieved with the current NGCs are only comparable with autografting when the gap is short... | 1 INTRODUCTION Peripheral nerve injuries (PNI) may have a dramatic impact on the patient's quality of life and can involve high health care expenses. The annual incidence of PNIs in developed countries range from 13 to 23 out of 100, 000 people. 1 In Europe, a PNI incidence rate of 3. 3% and 1. 8% has been reported in ... |
10. 1002/btm2. 10225 | 2,021 | Bioengineering & Translational Medicine | Introduction to Editorial Board Member: Professor Jennifer L. West | No abstract available | We are pleased to introduce Editorial Board Member Professor Jennifer L. West in this issue of Bioengineering and Translational Medicine (Figure 1 ). Prof. West will be Dean of Engineering and Applied Science at the University of Virginia (UVA) effective July 1, 2021, becoming the first woman to lead UVA Engineering. 1... |
10. 1002/btm2. 10244 | 2,021 | Bioengineering & Translational Medicine | Novel nanofibrous membrane‐supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing | Abstract The integration of biomaterials with cells for high overall performances is vitally important in tissue engineering, as scaffold‐free cell sheet lacks enough mechanical performance and cell viability while cell‐free scaffold possesses limited biological functions. In this study, we propose a new strategy to st... | 1 INTRODUCTION Regenerative medicine is promoted as a promising treatment for the difficult‐to‐treat diseases with physically impaired function in patients. 1 Replacement of injured or lost tissues with appropriate cells or tissues is one of most desired treatments in regenerative medicine. Tissue engineering is a prom... |
10. 1002/btm2. 10252 | 2,021 | Bioengineering & Translational Medicine | Transplantation of patient‐specific bile duct bioengineered with chemically reprogrammed and microtopographically differentiated cells | Abstract Cholangiopathy is a diverse spectrum of chronic progressive bile duct disorders with limited treatment options and dismal outcomes. Scaffold‐ and stem cell‐based tissue engineering technologies hold great promise for reconstructive surgery and tissue repair. Here, we report a combined application of 3D scaffol... | 1 INTRODUCTION Cholangiopathy, a syndrome of biliary obstruction and liver damage, represents a diverse spectrum of biliary tract diseases of different etiology frequently affecting multiple organs and making it a complex target for therapy. The treatment prospects are limited without proven therapeutic effects with wh... |
10. 1002/btm2. 10254 | 2,021 | Bioengineering & Translational Medicine | Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect | Abstract Bacterial wound infection is one of the most common nosocomial infections. The unnecessary employment of antibiotics led to raising the growth of antibiotic‐resistant bacteria. Accordingly, alternative armaments capable of accelerating wound healing along with bactericidal effects are urgently needed. Consider... | 1 INTRODUCTION Wound infection is a common and unsolved issue in preventing wound healing. Any kind of wound on the skin is susceptible to the accumulation of infectious bacteria. 1 With the spread of antibiotic‐resistant bacteria, employing antibiotics to prevent and treat wound infections is inefficient. In addition,... |
10. 1002/btm2. 10255 | 2,021 | Bioengineering & Translational Medicine | Area light source‐triggered latent angiogenic molecular mechanisms intensify therapeutic efficacy of adult stem cells | Abstract Light‐based therapy such as photobiomodulation (PBM) reportedly produces beneficial physiological effects in cells and tissues. However, most reports have focused on the immediate and instant effects of light. Considering the physiological effects of natural light exposure in living organisms, the latent react... | 1 INTRODUCTION Most studies on enhancing the therapeutic effect of light have focused on immediate and drastic changes in cells. However, it is essential to remember that changes in the body induced by light require a latent reaction period. For example, when ultraviolet (UV) rays hit the skin, melanin is formed in mel... |
10. 1002/btm2. 10260 | 2,021 | Bioengineering & Translational Medicine | Assessment of human | Abstract Medical devices made from poly(dimethylsiloxane) (PDMS)‐based silicone implants have been broadly used owing to their inert properties, biocompatibility, and low toxicity. However, long‐term implantation is usually associated with complications, such as capsular contracture due to excessive local inflammatory ... | 1 INTRODUCTION Poly(dimethylsiloxane) (PDMS)‐based silicone implants have been used in breast augmentation, rhinoplasty, and postmastectomy reconstruction in the plastic and reconstructive surgery fields for several decades. Recipients are usually satisfied with the tissue‐like mechanical properties of silicone‐based i... |
10. 1002/btm2. 10261 | 2,021 | Bioengineering & Translational Medicine | Polylysine for skin regeneration: A review of recent advances and future perspectives | Abstract There have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine‐... | Abbreviations Arg arginine Asn asparagine Asp aspartic acid ECM extracellular matrix FA focal adhesion FAK focal adhesion kinase Glu glutamic acid Gly glycine HA hyaluronic acid hADSC human adipose‐derived stem cell Hep heptose Ile isoleucine IM internal membrane Kdo ketodeoxyoctonate L‐b‐L layer‐by‐layer assembly Leu ... |
10. 1002/btm2. 10262 | 2,021 | Bioengineering & Translational Medicine | Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects | Abstract Bone grafts or prosthetic implant designing for clinical application is challenging due to the complexity of integrated physiological processes. The revolutionary advances of nanotechnology in the biomaterial field expedite and endorse the current unresolved complexity in functional bone graft and implant desi... | 1 INTRODUCTION Rare earth (RE) materials are found naturally in a thin layer of earth surfaces. 1, 2, 3 RE metals are found in the ores like basalts, granites, gneisses, shales, clays, and silicate rocks. Yttrium and lanthanides are the commonly known RE metals. The Finnish chemist Johan Gadolin isolated the first RE e... |
10. 1002/btm2. 10264 | 2,021 | Bioengineering & Translational Medicine | Transplantation of bioengineered Reelin‐loaded | Abstract Ischemic stroke is characterized by extensive neuronal loss, glial scar formation, neural tissue degeneration that leading to profound changes in the extracellular matrix, neuronal circuitry, and long‐lasting functional disabilities. Although transplanted neural stem cells (NSCs) can recover some of the functi... | 1 INTRODUCTION Despite numerous pharmacological and neuro‐rehabilitation approaches used to recuperate the neurological disorders, stroke is still the leading neurological disability with a high mortality rate. 1 Statistics have shown near 3. 4 million people will suffer a stroke by 2030 in the United States. 2 The lac... |
10. 1002/btm2. 10268 | 2,021 | Bioengineering & Translational Medicine | A biomimetic hyaluronic acid‐silk fibroin nanofiber scaffold promoting regeneration of transected urothelium | Abstract This study was designed to investigate the regulatory effect of hyaluronic acid (HA)—coating silk fibroin (SF) nanofibers during epithelialization of urinary tract for urethral regeneration. The obtained electrospun biomimetic tubular HA‐SF nanofiber scaffold is composed of a dense inner layer and a porous out... | Abbreviations ATR‐FTIR Fourier transform infrared spectra with attenuated total reflection head DAPI diamidino‐2‐phenylindole DMEM Dulbecco's modified Eagle's medium ECM extracellular matrix EDC 1‐ethyl‐3‐[3‐dimethylaminopropyl] carbodiimide hydrochloride FBS fetal bovine serum HA hyaluronic acid HFIP hexafluoroisoprop... |
10. 1002/btm2. 10271 | 2,021 | Bioengineering & Translational Medicine | Ventilation‐induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti‐inflammatory therapeutics | Abstract Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite the maintenance of blood oxygen homeostasis during ventilatory support. The biotrauma hypothesis advocates that mechanical forces from invasive ventilation trigger immunological mediators that spread system... | 1 INTRODUCTION Acute respiratory failure epitomizes a deleterious lung condition associated with high mortality rates (>35%) in critical care patients undergoing ventilatory support, 1 despite the maintenance of blood oxygen homeostasis. 2, 3 In deciphering this conundrum, the pulmonary biotrauma theory suggests a mult... |
10. 1002/btm2. 10272 | 2,022 | Bioengineering & Translational Medicine | null | Abstract Challenges to discovery and preclinical development of long‐acting release systems for protein therapeutics include protein instability, use of organic solvents during encapsulation, specialized equipment and personnel, and high costs of proteins. We sought to overcome these issues by combining remote‐loading ... | 1 INTRODUCTION Over the last several decades, the landscape of pharmaceutical drug products has been transformed from a near monolith of small molecules to a diverse space with biologics gaining more and more dominance. In 1982, the first genetically engineered form of insulin was approved. 1 By 2017, half of the top 1... |
10. 1002/btm2. 10274 | 2,021 | Bioengineering & Translational Medicine | Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing | Abstract Bacterial infection is one of the most frequent complications in the burn and chronic wounds. Inspired by natural existing superhydrophobic surface structures, a novel asymmetric wettable membrane was prepared using the electrospinning technique for facilitating the bacteria‐infected wound healing. Herein, the... | 1 INTRODUCTION Bacterial infection of a skin wound was the main reason of delayed wound healing, and high bacterial levels will hinder the progression of wound healing. 1 Unfortunately, prior study reported that infection caused by antimicrobial‐resistant pathogens may lead to 10 million annual deaths by the year 2050.... |
10. 1002/btm2. 10275 | 2,021 | Bioengineering & Translational Medicine | null | Abstract The pathogenesis of steroid‐induced osteonecrosis of the femoral head (SONFH) involves a glucocorticoid‐induced imbalance of osteogenic and adipogenic differentiation, and apoptosis of bone marrow mesenchymal stem cells (BMSCs). An increasing number of genes, especially noncoding RNAs, have been implicated in ... | 1 INTRODUCTION Steroid‐induced osteonecrosis of the femoral head (SONFH) is a progressive disease characterized by necrosis of the subchondral bone, accompanied by severe hip pain and dysfunction. 1 As the dominant treatment for SONFH, total hip arthroplasty (THA) can significantly relieve pain and improve the hip func... |
10. 1002/btm2. 10279 | 2,021 | Bioengineering & Translational Medicine | Development of a stem cell spheroid‐laden patch with high retention at skin wound site | Abstract Mesenchymal stem cells such as human adipose tissue‐derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor‐secreting abilities. However, certain points regarding conventional ADSC delivery systems, such a... | Abbreviations 3DP 3D cavity‐structured patch CLP stem cell‐laden 3D cavity‐structured patch EB ethidium bromide FDA fluorescein diacetate hADSC human adipose tissue‐derived mesenchymal stem cell MSC mesenchymal stem cell PBS phosphate‐buffered saline PDMS polydimethylsiloxane qRT‐PCR quantitative reverse transcription‐... |
10. 1002/btm2. 10297 | 2,022 | Bioengineering & Translational Medicine | Evaluation of native and non‐native biomaterials for engineering human skin tissue | Abstract A variety of human skin models have been developed for applications in regenerative medicine and efficacy studies. Typically, these employ matrix molecules that are derived from non‐human sources along with human cells. Key limitations of such models include a lack of cellular and tissue microenvironment that ... | 1 INTRODUCTION Tissue engineering is a rapidly advancing multidisciplinary research field with significant promise for regenerative medicine that aims to fabricate and develop tissues and organs in vitro to replace those damaged by disease or injury. 1, 2 For example, bioengineered skin grafts could be used to treat cu... |
10. 1002/btm2. 10300 | 2,022 | Bioengineering & Translational Medicine | Advanced strategies to thwart foreign body response to implantable devices | Abstract Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long‐term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, event... | 1 INTRODUCTION In the past years, the rising demand for implantable medical devices (IMDs) has been fostered by advances in manufacturing technologies and biomaterial science. This trend is mainly driven by the increasing geriatric population, more prone to chronic conditions, and the increased demand for organ transpl... |
10. 1002/btm2. 10302 | 2,022 | Bioengineering & Translational Medicine | Integrated bioactive scaffold with aptamer‐targeted stem cell recruitment and growth factor‐induced pro‐differentiation effects for anisotropic meniscal regeneration | Abstract Reconstruction of the knee meniscus remains a significant clinical challenge owing to its complex anisotropic tissue organization, complex functions, and limited healing capacity in the inner region. The development of in situ tissue‐engineered meniscal scaffolds, which provide biochemical signaling to direct ... | 1 INTRODUCTION Meniscus tears are the most prevalent injury of the knee joint and are often accompanied by acute anterior cruciate ligament (ACL) lesions. 1 Meniscal injuries that occur in the avascular region typically cannot heal and subsequently represent a major osteoarthritis (OA) risk factor. 2, 3 Currently, trea... |
10. 1002/btm2. 10303 | 2,022 | Bioengineering & Translational Medicine | Adaptive multi‐degree‐of‐freedom in situ bioprinting robot for hair‐follicle‐inclusive skin repair: A preliminary study conducted in mice | Abstract Skin acts as an essential barrier, protecting organisms from their environment. For skin trauma caused by accidental injuries, rapid healing, personalization, and functionality are vital requirements in clinical, which are the bottlenecks hindering the translation of skin repair from benchside to bedside. Here... | 1 INTRODUCTION The skin is composed of the epidermis, dermis, and subcutaneous tissue, and it is the largest and most complex organ in the human body. 1 It not only serves as a barrier between the human body and the environment, but also performs physiological functions involving the immune and endocrine systems, physi... |
10. 1002/btm2. 10306 | 2,022 | Bioengineering & Translational Medicine | Carboxymethyl chitosan prolongs adenovirus‐mediated expression of | Abstract Effective and safe liver‐directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been widely used for efficacious in vivo gene delivery, their translational utilities are severely limited due to the short duration of transgene expression and solic... | 1 INTRODUCTION Liver is a key organ in the human body and carries out a variety of essential functions including digestion, metabolism, detoxification, immunity and blood clotting. 1 At the cellular level, hepatocytes constitute the vast majority of cells in the liver parenchyma and are implicated in the majority of mo... |
10. 1002/btm2. 10307 | 2,022 | Bioengineering & Translational Medicine | Portable hand‐held bioprinters promote in situ tissue regeneration | Abstract Three‐dimensional bioprinting, as a novel technique of fabricating engineered tissues, is positively correlated with the ultimate goal of regenerative medicine, which is the restoration, reconstruction, and repair of lost and/or damaged tissue function. The progressive trend of this technology resulted in deve... | Abbreviations AM additive manufacturing ADSCs adipose‐derived stromal/stem cells AG agarose BMP‐2 bone morphogenetic protein 2 COL1 collagen type I CT computed tomography ECM extracellular matrix FDM fused deposition modeling GelMA gelatin methacryloyl HGM host–guest macromer hBMSCs human bone marrow‐derived mesenchyma... |
10. 1002/btm2. 10312 | 2,022 | Bioengineering & Translational Medicine | Engineering hypertrophic cartilage grafts from lipoaspirate for | Abstract Developmental engineering of living implants from different cell sources capable of stimulating bone regeneration by recapitulating endochondral ossification (ECO) is a promising strategy for large bone defect reconstruction. However, the clinical translation of these cell‐based approaches is hampered by compl... | 1 INTRODUCTION The body's repair mechanisms are often unable to spontaneously heal large bone defects resulting from traumas, tumors, infections, and congenital malformations. These defects represent a significant medical concern and socioeconomic burden. Bone is the second most frequently transplanted tissue after blo... |
10. 1002/btm2. 10313 | 2,022 | Bioengineering & Translational Medicine | A high‐throughput biomimetic bone‐on‐a‐chip platform with artificial intelligence‐assisted image analysis for osteoporosis drug testing | Abstract Although numerous organ‐on‐a‐chips have been developed, bone‐on‐a‐chip platforms have rarely been reported because of the high complexity of the bone microenvironment. With an increase in the elderly population, a high‐risk group for bone‐related diseases such as osteoporosis, it is essential to develop a prec... | 1 INTRODUCTION Bone is a rigid but dynamic tissue that performs essential functions in the body, such as structural support, mobility, endocrine regulation, and mineral storage. 1, 2 It is continuously remodeled through highly coordinated actions of several types of bone cells, such as osteocytes, osteoblasts, and oste... |
10. 1002/btm2. 10315 | 2,022 | Bioengineering & Translational Medicine | Nanocomposite hydrogels for biomedical applications | Abstract Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in the field of nanomedicine. However, nanomaterials do possess disadvantages that cannot be ignored, such as burst release, rapid elimination, and poor bioadhesion. Hydrogel... | 1 INTRODUCTION Nanomaterials can be divided into zero‐dimensional materials (0DM), one‐dimensional materials (1DM), and two‐dimensional materials (2DM) according to their size, length‐diameter ratio, and diameter‐thickness ratio. 1 Nanomaterials exhibit huge application potentials in various fields based on their nano ... |
10. 1002/btm2. 10317 | 2,022 | Bioengineering & Translational Medicine | Fabrication of bone‐derived decellularized extracellular matrix/ceramic‐based biocomposites and their osteo/odontogenic differentiation ability for dentin regeneration | Abstract The goal of this study was to fabricate bioactive cell‐laden biocomposites supplemented with bone‐derived decellularized extracellular matrix (dECM) with calcium phosphate ceramic, and to assess the effect of the biocomponents on the osteogenic and odontogenic differentiation of human dental pulp stem cells (h... | 1 INTRODUCTION Biophysically and biochemically functionalized three‐dimensional (3D) constructs have become critical for the successful regeneration of various tissues. 1, 2 In particular, tissue engineering strategies, including cell‐based regeneration using dental pulp stem cells (DPSCs) and scaffolds combined with b... |
10. 1002/btm2. 10319 | 2,022 | Bioengineering & Translational Medicine | An | Abstract Neurogenic erectile dysfunction (nED) is one of the most common and intractable postoperative complications of rectal and prostate cancer surgery and sometimes accompanies patients lifelong. The transplantation of stem cells has been proved a promising way for treatment. However, the therapeutic efficacy is se... | 1 INTRODUCTION Rectal and prostate cancers are both among the most common malignant tumors with increasing prevalence worldwide. Radical resection of the lesion is one of the most efficient treatment options. Postoperative erectile dysfunction (ED) is a significant complication and frequently occurs in male patients fo... |
10. 1002/btm2. 10321 | 2,022 | Bioengineering & Translational Medicine | A bioprinted complex tissue model for myotendinous junction with biochemical and biophysical cues | Abstract In the musculoskeletal system, the myotendinous junction (MTJ) is optimally designed from the aspect of force transmission generated from a muscle through a tendon onto the bone to induce movement. Although the MTJ is a key complex tissue in force transmission, the realistic fabrication, and formation of compl... | 1 INTRODUCTION In the human body, most tissues have unique physical and biological functions, with tissues with physically differing properties being present to perform specific biological or biomechanical functions. Furthermore, heterogeneous tissues are connected by specific interfaces for performing complicated func... |
10. 1002/btm2. 10324 | 2,022 | Bioengineering & Translational Medicine | null | Abstract Bioengineered tissues or organs produced using matrix proteins or components derived from xenogeneic sources pose risks of allergic responses, immune rejection, or even autoimmunity. Here, we report successful xeno‐free isolation, expansion, and cryopreservation of human endothelial cells (EC), fibroblasts (FB... | 1 INTRODUCTION Bioengineered skin substitutes are approved for clinical use in patients with nonhealing skin ulcers or surgically resected skin cancers, but all currently available products contain xenogeneic components, either in the form of matrix molecules or human cells that have been expanded in culture using medi... |
10. 1002/btm2. 10326 | 2,022 | Bioengineering & Translational Medicine | Transplantation of neuron‐inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury | Abstract In this study, we aimed to investigate the recovery after traumatic spinal cord injury (SCI) by inducing cellular differentiation of transplanted neural stem cells (NSCs) into neurons. We dissociated NSCs from the spinal cords of Fisher 344 rat embryos. An injectable gel crosslinked with glycol chitosan and ox... | 1 INTRODUCTION Traumatic spinal cord injury (SCI) results in severe functional impairment accompanied by a loss of neurons at the injury site. 1 Although multiple neurotrophic factors have been administered to lesions in an effort to improve the recovery of injured neurons, damaged neurons rarely recover due to their p... |
10. 1002/btm2. 10327 | 2,022 | Bioengineering & Translational Medicine | Extracellular matrix bioink boosts stemness and facilitates transplantation of intestinal organoids as a biosafe Matrigel alternative | Abstract Organoids hold inestimable therapeutic potential in regenerative medicine and are increasingly serving as an in vitro research platform. Still, their expanding applications are critically restricted by the canonical culture matrix and system. Synthesis of a suitable bioink of bioactivity, biosecurity, tunable ... | 1 INTRODUCTION The intestinal epithelium hosts short‐lived differentiated cells of diverse lineages with a renewal cycle of 4–5 days and immortalized proliferative ISCs, which reside at the bottom of crypts. 1 This subtle homeostasis of the epithelium depends on bidirectional gradients of proliferative and differentiat... |
10. 1002/btm2. 10328 | 2,022 | Bioengineering & Translational Medicine | An injectable gelatin/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury | Abstract Abnormal endometrial receptivity is a major cause of the failure of embryo transplantation, which may lead to infertility, adverse pregnancy, and neonatal outcomes. While hormonal treatment has dramatically improved the fertility outcomes in women with endometriosis, a substantial unmet need persists in the tr... | 1 INTRODUCTION The uterus is one of the most important reproductive organs for women, and the endometrium (as the place for implantation, embryonic development, and pregnancy maintenance of female fertilized eggs) is the key factor for the success of pregnancy. 1, 2 However, endometrial damage was caused by physical in... |
10. 1002/btm2. 10330 | 2,022 | Bioengineering & Translational Medicine | Bioprinted | Abstract Extrusion‐based bioprinting is one of the most effective methods for fabricating cell‐laden mesh structures. However, insufficient cellular activities within the printed cylindrical cell‐matrix blocks, inducing low cell‐to‐cell interactions due to the disturbance of the matrix hydrogel, remain to be addressed.... | 1 INTRODUCTION Bioprinting for fabricating cell‐laden porous scaffolds has become one of the most important processes in tissue engineering. 1, 2, 3, 4, 5 As reported by several researchers, cell‐laden scaffolds offer numerous advantages, such as versatility in efficiently loading different cell types in a desired posi... |
10. 1002/btm2. 10332 | 2,022 | Bioengineering & Translational Medicine | Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration | Abstract Novel polycaprolactone‐based polyurethane (PCL‐PU) copolymers with hyperelasticity, shape‐memory, and ultra‐cell‐adhesion properties are reported as clinically applicable tissue‐regenerative biomaterials. New isosorbide derivatives (propoxylated or ethoxylated ones) were developed to improve mechanical propert... | 1 INTRODUCTION The growing demand for versatile, biocompatible synthetic polymers in biomedical engineering and medical devices has galvanized research beyond the biocompatibility and tissue‐regenerative ability of FDA‐approved synthetic polymers such as polycaprolactone (PCL), poly(methyl methacrylate) (PMMA), poly(la... |
10. 1002/btm2. 10333 | 2,022 | Bioengineering & Translational Medicine | Biomedical applications of three‐dimensional bioprinted craniofacial tissue engineering | Abstract Anatomical complications of the craniofacial regions often present considerable challenges to the surgical repair or replacement of the damaged tissues. Surgical repair has its own set of limitations, including scarcity of the donor tissues, immune rejection, use of immune suppressors followed by the surgery, ... | 1 INTRODUCTION The terms regenerative medicine and tissue engineering are often used interchangeably in medicine. However, regenerative medicine is a general term that incorporates tissue engineering and, at the same time, is concerned about the research in self‐healing. During self‐healing, the body uses its cellular ... |
10. 1002/btm2. 10334 | 2,022 | Bioengineering & Translational Medicine | Light‐controlled scaffold‐ and serum‐free hard palatal‐derived mesenchymal stem cell aggregates for bone regeneration | Abstract Cell aggregates that mimic in vivo cell–cell interactions are promising and powerful tools for tissue engineering. This study isolated a new, easily obtained, population of mesenchymal stem cells (MSCs) from rat hard palates named hard palatal‐derived mesenchymal stem cells (PMSCs). The PMSCs were positive for... | 1 INTRODUCTION Mesenchymal stem cells (MSCs) have been applied in bone regeneration, 1, 2 bone‐tendon healing, 3 cartilage formation, 4 and dental pulp regeneration. 5 MSCs usually originate from bone marrow. However, these stem cells are donated by other patients and they may show immunogenicity. Therefore, autologous... |
10. 1002/btm2. 10343 | 2,022 | Bioengineering & Translational Medicine | null | Abstract MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II‐derived noncoding RNAs act through post‐transcriptional controlling of different proteins and their allied pathways.... | 1 INTRODUCTION Chronic wounds, particularly venous ulcers, diabetic ulcers, arterial insufficiency ulcers, and pressure ulcers, are arduous and exorbitant to cure. 1 Globally, many people suffer from chronic wounds with a growing prevalence every year. The Considerable but often unrecognized impact on patients and the ... |
10. 1002/btm2. 10345 | 2,022 | Bioengineering & Translational Medicine | Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing | Abstract Tendon healing is a complex process involving inflammation, proliferation, and remodeling, eventually achieving a state of hypocellularity and hypovascularity. Currently, few treatments can satisfactorily restore the structure and function of native tendon. Bioactive glass (BG) has been shown to possess immuno... | 1 INTRODUCTION Promoting tendon healing remains an unsolved challenge in orthopedics. As the largest and strongest tendon in the human body, Achilles tendon is one of the most frequently ruptured tendons, with an incidence of 12–18 per 100, 000. 1, 2 Healing of ruptured Achilles tendon is difficult because of its limit... |
10. 1002/btm2. 10347 | 2,022 | Bioengineering & Translational Medicine | Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering | Abstract A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue enginee... | 1 INTRODUCTION Drug treatments are efficient mainly in the case of limited minor injuries, while most extensive and progressive damages to tissues and subsequent loss of organ functions are much more severe. 1, 2 Such conditions bring about the possibility of organ failure, which may require a completely functional rep... |
10. 1002/btm2. 10361 | 2,022 | Bioengineering & Translational Medicine | Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration | Abstract One of the bottlenecks of advanced study on tissue engineering in regenerative medicine is rapid and functional vascularization. For a deeper comprehension of vascularization, the exhaustive, dynamic, and three‐dimensional depiction of perfused vascular network reconstruction during peripheral nerve regenerati... | Abbreviations ANOVA one‐way analysis of variance CT computed tomography CMAPs compound muscle action potentials DMEM Dulbecco's modified Eagle's medium HE hematoxylin–eosin SD Sprague–Dawley SKPs skin‐derived precursors SKP‐SCs Schwann cells differentiated from skin‐derived precursors VEGF vascular endothelial growth f... |
10. 1002/btm2. 10364 | 2,022 | Bioengineering & Translational Medicine | Kartogenin (KGN)/synthetic melanin nanoparticles (SMNP) loaded theranostic hydrogel scaffold system for multiparametric magnetic resonance imaging guided cartilage regeneration | Abstract Cartilage regeneration after injury is still a great challenge in clinics, which suffers from its avascularity and poor proliferative ability. Herein we designed a novel biocompatible cellulose nanocrystal/GelMA (gelatin‐methacrylate anhydride)/HAMA (hyaluronic acid‐methacrylate anhydride)‐blended hydrogel sca... | 1 INTRODUCTION Articular cartilage injury and pathological changes caused by trauma or chronic diseases eventually lead to joint pain and functional disability, which is a common clinical disease. 1 Due to its avascularity, low cellularity, and poor migration ability, it is difficult for cartilage tissue to gain self‐r... |
10. 1002/btm2. 10378 | 2,022 | Bioengineering & Translational Medicine | Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms | Abstract Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell culture and animal models, which have been used to analyze AD pathology and search for effective treatments for decades, have sig... | 1 INTRODUCTION Alzheimer's disease (AD) is a cognitive disorder that affects approximately 5. 8 million Americans. It is characterized by memory loss, confusion, lack of awareness, and other symptoms that disrupt daily life and lead to a loss of independence. 1 AD mainly affects the elderly population with approximatel... |
10. 1002/btm2. 10383 | 2,022 | Bioengineering & Translational Medicine | Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues | Abstract Tissue engineering (TE) is currently considered a cutting‐edge discipline that offers the potential for developing treatments for health conditions that negatively affect the quality of life. This interdisciplinary field typically involves the combination of cells, scaffolds, and appropriate induction factors ... | Abbreviations ADSCs adipose‐derived stem cells BDNF brain‐derived neurotrophic factor bFGF basic fibroblast growth factor BMPs bone morphogenic proteins CS chitosan ECM extracellular matrix EGF epidermal growth factor FDA Food and Drug Administration FGF fibroblast growth factor GDNF glial cell line‐derived neurotrophi... |
10. 1002/btm2. 10385 | 2,022 | Bioengineering & Translational Medicine | Mussel‐inspired biomaterials: From chemistry to clinic | Abstract After several billions of years, nature still makes decisions on its own to identify, develop, and direct the most effective material for phenomena/challenges faced. Likewise, and inspired by the nature, we learned how to take steps in developing new technologies and materials innovations. Wet and strong adhes... | 1 INTRODUCTION From antiquity and ancient times, humankind has always been inspiring by the nature to make proficient use and design materias. Natural evolution has spent millions of years balancing and optimizing almost everything. Correspondingly, every aspect of natural phenomena has been inspired by scientists to m... |
10. 1002/btm2. 10386 | 2,022 | Bioengineering & Translational Medicine | Cell loaded hydrogel containing Ag‐doped bioactive glass–ceramic nanoparticles as skin substitute: Antibacterial properties, immune response, and scarless cutaneous wound regeneration | Abstract An ideal tissue‐engineered dermal substitute should possess angiogenesis potential to promote wound healing, antibacterial activity to relieve the bacterial burden on skin, as well as sufficient porosity for air and moisture exchange. In light of this, a glass–ceramic (GC) has been incorporated into chitosan a... | 1 INTRODUCTION Bacterial infection is a vicious, unaddressed problem in the healing of skin wounds. Prolonged bacterial infections are critical challenges in the management of chronic wounds. Bacterial biofilms play a significant role in persistent bacterial infections. 1, 2, 3 Skin substitutes are acellular or cellula... |
10. 1002/btm2. 10389 | 2,022 | Bioengineering & Translational Medicine | Modulating neuroinflammation through molecular, cellular and biomaterial‐based approaches to treat spinal cord injury | Abstract The neuroinflammatory response that is elicited after spinal cord injury contributes to both tissue damage and reparative processes. The complex and dynamic cellular and molecular changes within the spinal cord microenvironment result in a functional imbalance of immune cells and their modulatory factors. To f... | 1 INTRODUCTION Spinal cord injury (SCI) is one of the leading causes of long‐term physical impairment, with an increase in global prevalence of approximately 368 per 100, 000 patients over the last 30 years. 1 According to epidemiological studies, the most common causes of SCI across all populations result from falls, ... |
10. 1002/btm2. 10393 | 2,022 | Bioengineering & Translational Medicine | “Guide” of muscone modification enhanced brain‐targeting efficacy and anti‐glioma effect of lactoferrin modified | Abstract Glioma is one of the most aggressive malignant diseases for human health. It is difficult to resect completely due to their invasiveness. The targeted delivery, as a noninvasive approach, is a major strategy for the development of treatments for brain tumors. Lactoferrin (Lf) receptors are over‐expressed in bo... | 1 INTRODUCTION Gliomas are the most common primary malignant tumors, accounting for about 80% in malignant brain tumors. 1 Since most gliomas grow invasively in the cerebral hemisphere and cannot be completely removed by the surgery, chemotherapy remains an important treatment for malignant glioma. However, the presenc... |
10. 1002/btm2. 10397 | 2,022 | Bioengineering & Translational Medicine | Hybrid cell constructs consisting of bioprinted cell‐spheroids | Abstract Bioprinted cell constructs have been investigated for regeneration of various tissues. However, poor cell–cell interactions have limited their utility. Although cell‐spheroids offer an alternative for efficient cell–cell interactions, they complicate bioprinting. Here, we introduce a new cell‐printing process,... | 1 INTRODUCTION Recently, cell printing has been used to fabricate a variety of complex tissue constructs, such as biomedical scaffolds and in‐vitro models used to evaluate therapeutic biocomponents, among others. 1, 2, 3 This fabrication technique can provide biochemical/biophysical cues and even place cells in a desir... |
10. 1002/btm2. 10409 | 2,022 | Bioengineering & Translational Medicine | Living prosthetic breast for promoting tissue regeneration and inhibiting tumor recurrence | Abstract Developing a living prosthetic breast to inhibit potential breast cancer recurrence and simultaneously promote breast reconstruction would be a promising strategy for clinical treatment of breast cancer after mastectomy. Here, a living prosthetic breast in the form of injectable gelatin methacryloyl microspher... | 1 INTRODUCTION As the most diagnosed and the leading causes of cancer death among women worldwide, there were roughly 2. 3 million new breast cancer cases and 685, 000 breast cancer deaths in 2020. 1 Like any cancer, one of the most imminent issues the breast cancer patients face would be the risk of its recurrence aft... |
10. 1002/btm2. 10414 | 2,022 | Bioengineering & Translational Medicine | null | Abstract Bone injury caused changes to surrounding tissues, leading to a large number of osteoclasts appeared to clear the damaged bone tissue before bone regeneration. However, overactive osteoclasts will inhibit bone formation. In this study, we prepared methacrylylated gelatin (GelMA)‐based hydrogel to co‐crosslink ... | 1 INTRODUCTION Femur fractures and defects caused by surgical resection of osteosarcoma are usually accompanied by two major problems in clinical treatment: nonunion of the fracture 1 and avascular necrosis of the femur head. 2, 3 The incidence of femur fractures is concentrated in the elderly, and the treatment of ost... |
10. 1002/btm2. 10423 | 2,022 | Bioengineering & Translational Medicine | Fluidic integrated | Abstract Herein, we report the first study to create a three‐dimensional (3D) bioprinted artificial larynx for whole‐laryngeal replacement. Our 3D bio‐printed larynx was generated using extrusion‐based 3D bioprinter with rabbit's chondrocyte‐laden gelatin methacryloyl (GelMA)/glycidyl‐methacrylated hyaluronic acid (GMH... | 1 INTRODUCTION Three‐dimensional (3D) bioprinting involves the fabrication of cell‐laden bioinks into functional tissue/organ constructs using 3D digital models for human tissue and organ regeneration. 1, 2 Recent advances in tissue engineering have enabled 3D bioprinting using various biocompatible materials, includin... |
10. 1002/btm2. 10435 | 2,022 | Bioengineering & Translational Medicine | Preparation and assessment of an optimized multichannel acellular nerve allograft for peripheral nerve regeneration | Abstract Peripheral nerve regeneration after injury is still a clinical problem. The application of autologous nerve grafting, the gold standard treatment, is greatly restricted. Acellular nerve allografts (ANAs) are considered promising alternatives, but they are difficult to achieve satisfactory therapeutic outcomes,... | 1 INTRODUCTION Peripheral nerve injury (PNI) is the primary type of traumatic damage in the nervous system, affecting over one million people worldwide annually with a high prevalence among younger individuals. 1, 2 Currently, autologous nerve grafting is still considered the “gold standard” for peripheral nerve repair... |
10. 1002/btm2. 10440 | 2,022 | Bioengineering & Translational Medicine | Engineering pedicled vascularized bladder tissue for functional bladder defect repair | Abstract An engineered bladder construct that mimics the structural and functional characteristics of native bladder is a promising therapeutic option for bladder substitution. We previously showed that pedicled vascularized smooth muscle tissue fabricated by grafting smooth muscle cell (SMC) sheets onto an axial capsu... | 1 INTRODUCTION Tissue engineering has been proven to be a promising alternative for gastrointestinal segments in clinical bladder reconstruction over the past few decades. 1 Although great achievements have been made in preclinical researches, the clinical applications encounter a series of problems, leading to unsatis... |
10. 1002/btm2. 10441 | 2,022 | Bioengineering & Translational Medicine | Biomimetic cell membrane‐coated poly(lactic‐ | Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability for sustained and controlled drug release. To prolong NP circulation time, enable target‐specific drug delivery and overcome physiological barriers, NPs camou... | 1 INTRODUCTION Conventional therapies used for the management of various disease conditions rely on the use of systemic drug administration, which is largely nontargeted to the site of disease. 1 Consequently, these agents affect both diseased cells in target tissues, and healthy cells at other anatomic sites, leading ... |
10. 1002/btm2. 10447 | 2,022 | Bioengineering & Translational Medicine | Peptide‐functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration | Abstract As a prominent approach to treat intervertebral disc (IVD) degeneration, disc transplantation still falls short to fully reconstruct and restore the function of native IVD. Here, we introduce an IVD scaffold consists of a cellulose‐alginate double network hydrogel‐based annulus fibrosus (AF) and a cellulose hy... | 1 INTRODUCTION Degenerative disc disease (DDD) entails the breakdown of one or more intervertebral discs (IVD). Common symptoms include disc bulging, herniation, and the formation of osteophyte (bone spurs). These conditions often interfere with nervous structures and cause pain in back or neck which can eventually lea... |
10. 1002/btm2. 10448 | 2,022 | Bioengineering & Translational Medicine | Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes | Abstract Neural progenitor cell (NPC) transplantation is a promising approach for repairing spinal cord injury (SCI). However, cell survival, maturation and integration after transplantation are still major challenges. Here, we produced a novel centimeter‐scale human spinal cord neural tissue (hscNT) construct with hum... | 1 INTRODUCTION Spinal cord injury (SCI) is a devastating traumatic injury characterized by the massive loss of neurons and glial cells. 1 Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy with the potential to replenish lost neurons. Transplantation of NPCs into the injured spinal cord ca... |
10. 1002/btm2. 10464 | 2,022 | Bioengineering & Translational Medicine | Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids | Abstract Multicellular spheroids made of stem cells can act as building blocks that fuse to capture complex aspects of native in vivo environments, but the effect of hydrogel viscoelasticity on cell migration from spheroids and their fusion remains largely unknown. Here, we investigated the effect of viscoelasticity on... | 1 INTRODUCTION Cell migration is a critical process in wound healing and regeneration of various tissues. 1 In living tissues, cells are physically confined within a complex and three‐dimensional (3D) extracellular matrix (ECM) to which they are mechanically coupled by adhesion molecules such as integrins. These molecu... |
10. 1002/btm2. 10468 | 2,022 | Bioengineering & Translational Medicine | Stirred culture of cartilaginous microtissues promotes chondrogenic hypertrophy through exposure to intermittent shear stress | Abstract Cartilage microtissues are promising tissue modules for bottom up biofabrication of implants leading to bone defect regeneration. Hitherto, most of the protocols for the development of these cartilaginous microtissues have been carried out in static setups, however, for achieving higher scales, dynamic process... | 1 INTRODUCTION Patients with failing intrinsic tissue regeneration, such as those with complex and large bone defects in compromised biological conditions, need solutions coming from the field of tissue engineering. 1 There is growing evidence that the implantation of engineered cartilage‐intermediate tissues results i... |
10. 1002/btm2. 10471 | 2,022 | Bioengineering & Translational Medicine | An immunometabolic patch facilitates mesenchymal stromal/stem cell therapy for myocardial infarction through a macrophage‐dependent mechanism | Abstract Mesenchymal stromal/stem cells (MSCs) have emerged as a promising approach against myocardial infarction. Due to hostile hyperinflammation, however, poor retention of transplanted cells seriously impedes their clinical applications. Proinflammatory M1 macrophages, which rely on glycolysis as their main energy ... | 1 INTRODUCTION Myocardial infarction (MI), which is principally caused by the stenosis and occlusion of coronary arteries, remains the leading cause of most acute cardiac events and deaths worldwide. 1 Many studies and clinical trials have supported the efficacy of mesenchymal stromal/stem cells (MSCs) in patients with... |
10. 1002/btm2. 10475 | 2,022 | Bioengineering & Translational Medicine | The novel hyaluronic acid granular hydrogel attenuates osteoarthritis progression by inhibiting the | Abstract In patients with mild osteoarthritis (OA), two to four monthly injections are required for 6 months due to the degradation of hyaluronic acid (HA) by peroxidative cleavage and hyaluronidase. However, frequent injections may lead to local infection and also cause inconvenience to patients during the COVID‐19 pa... | 1 INTRODUCTION Osteoarthritis (OA) is a serious chronic degenerative disease characterized by articular cartilage loss, synovitis, subchondral bone sclerosis, and osteophyte, which is the main cause of joint pain and disability. 1, 2, 3, 4, 5, 6 The progression of OA may ultimately lead to keen arthroplasty surgery to ... |
10. 1002/btm2. 10484 | 2,023 | Bioengineering & Translational Medicine | Development of a mammalian neurosensory full‐thickness skin equivalent and its application to screen sensitizing stimuli | Abstract Human skin equivalents (HSEs) are an increasingly popular research tool due to limitations associated with animal testing for dermatological research. They recapitulate many aspects of skin structure and function, however, many only contain two basic cell types to model dermal and epidermal compartments, which... | 1 INTRODUCTION Human skin equivalents (HSEs) are bioengineered 3D tissues that recapitulate aspects of skin structure and function in vitro. The use of HSEs has become increasingly popular as restrictions limit animal testing, 1 and many applications of HSEs have been demonstrated including cosmetic science, 2, 3, 4, 5... |
10. 1002/btm2. 10493 | 2,023 | Bioengineering & Translational Medicine | Cell recognitive bioadhesive‐based osteogenic barrier coating with localized delivery of bone morphogenetic protein‐2 for accelerated guided bone regeneration | Abstract Titanium mesh (Ti‐mesh) for guided bone regeneration (GBR) approaches has been extensively considered to offer space maintenance in reconstructing the alveolar ridge within bone defects due to its superb mechanical properties and biocompatibility. However, soft tissue invasion across the pores of the Ti‐mesh a... | 1 INTRODUCTION In dental implant therapy, the reconstruction of alveolar ridges with adequate levels of volume and quality is critical for the successful treatment of bone defects. 1 Guided bone regeneration (GBR) is a widely used technique as part of the process for local augmentation and defect restitution in the alv... |
10. 1002/btm2. 10495 | 2,023 | Bioengineering & Translational Medicine | Waffle‐inspired hydrogel‐based macrodevice for spatially controlled distribution of encapsulated therapeutic microtissues and pro‐angiogenic endothelial cells | Abstract Macro‐encapsulation systems for delivery of cellular therapeutics in diabetes treatment offer major advantages such as device retrievability and high cell packing density. However, microtissue aggregation and absence of vasculature have been implicated in the inadequate transfer of nutrients and oxygen to the ... | 1 INTRODUCTION Encapsulation of exogenous therapeutic cells in hydrogel‐based devices is a promising strategy enabling long‐term, immunosuppressant‐free cellular therapy for the treatment of hormone and protein‐deficiency diseases, such as type 1 diabetes, hemophilia A, or neurodegenerative diseases. 1, 2 Transplanted ... |
10. 1002/btm2. 10497 | 2,023 | Bioengineering & Translational Medicine | Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration? | Abstract Reconstruction of posterior lamellar eyelids remains challenging due to their delicate structure, highly specialized function, and cosmetic concerns. Current clinically available techniques for posterior lamellar reconstruction mainly focus on reconstructing the contour of the eyelids. However, the posterior l... | 1 INTRODUCTION The eyelids play critical roles in protecting the globe, maintaining ocular surface hydration, and expressing emotions. Anatomically, the eyelids contain two layers, namely, the anterior lamella and the posterior lamella 1 (Figure 1a ). The eyelids not only physically provide protective coverage for the ... |
10. 1002/btm2. 10503 | 2,023 | Bioengineering & Translational Medicine | Polysaccharide‐based biomaterials in a journey from | Abstract 3D printing is a state‐of‐the‐art technology for the fabrication of biomaterials with myriad applications in translational medicine. After stimuli‐responsive properties were introduced to 3D printing (known as 4D printing), intelligent biomaterials with shape configuration time‐dependent character have been de... | 1 INTRODUCTION Polysaccharides, mainly chitosan, 1 alginate, 2 agarose, 3 starch, 4 glycogen, 5 and cellulose, 6 as well as their blends 7 have been widely used for biomedical purposes, ranging from imaging and diagnostic to therapeutic, delivery and biosensing applications. 8, 9 The bioactivity of polysaccharides give... |
10. 1002/btm2. 10509 | 2,023 | Bioengineering & Translational Medicine | Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is | Abstract The fate determination of bone marrow mesenchymal stem/stromal cells (BMSC) is tightly regulated by mechanical cues, including fluid shear stress. Knowledge of mechanobiology in 2D culture has allowed researchers in bone tissue engineering to develop 3D dynamic culture systems with the potential for clinical t... | 1 INTRODUCTION The fate and growth of bone marrow mesenchymal stem/stromal cells (BMSC) are tightly regulated by mechano‐environmental factors. 1, 2 The forces of load and torsion applied to bone are converted to shear forces by altered interstitial fluid flow in bone marrow, which is exerted on the resident cells, inc... |
10. 1002/btm2. 10512 | 2,023 | Bioengineering & Translational Medicine | Prediction of drug permeation through microneedled skin by machine learning | Abstract Stratum corneum is the outermost layer of the skin preventing external substances from entering human body. Microneedles (MNs) are sharp protrusions of a few hundred microns in length, which can penetrate the stratum corneum to facilitate drug permeation through skin. To determine the amount of drug delivered ... | 1 INTRODUCTION A microneedle (MN) patch consists of an array of MNs of a few hundred microns in length, made of biocompatible materials, such as metals or polymers. 1 These MNs can enhance drug permeation into the skin and/or main circulation, by creating multiple micron‐sized passages through skin, a formidable biolog... |
10. 1002/btm2. 10518 | 2,023 | Bioengineering & Translational Medicine | Adjustable extracellular matrix rigidity tumor model for studying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression | Abstract Pancreatic ductal adenocarcinomas (PDAC) is one of the stiffest malignancies with strong solid stresses. Increasing stiffness could alter cellular behavior and trigger internal signaling pathways and is strongly associated with a poor prognosis in PDAC. So far, there has been no report on of an experimental mo... | Abbreviations 3D three dimensions AJCC 8th American Joint Committee on Cancer staging system B B cells CAF cancer‐associated fibroblasts CCTCC China Center For Type Culture Collection CD4 + Th CD4 + helper T cells CVF collagen volume fraction DC dendritic cells DEG differentially expressed gene DoF degree of functional... |
10. 1002/btm2. 10522 | 2,023 | Bioengineering & Translational Medicine | Engineering a | Abstract Engineering a conduction‐consistent cardiac patch has direct implications to biomedical research. However, there is difficulty in obtaining and maintaining a system that allows researchers to study physiologically relevant cardiac development, maturation, and drug screening due to the issues around inconsisten... | 1 INTRODUCTION The surfaces of butterfly wings have special nanostructures arranged in parallel which can generate cellular alignment; these structures can also be electro‐mechanically manipulated in order to form vivid structural colors. 1, 2, 3, 4, 5, 6 Although butterfly wings have some individual differences and po... |
10. 1002/btm2. 10525 | 2,023 | Bioengineering & Translational Medicine | Partial decellularization eliminates immunogenicity in tracheal allografts | Abstract There is currently no suitable autologous tissue to bridge large tracheal defects. As a result, no standard of care exists for long‐segment tracheal reconstruction. Tissue engineering has the potential to create a scaffold from allografts or xenografts that can support neotissue regeneration identical to the n... | 1 INTRODUCTION Tracheal defects are rare but life‐threatening. End‐to‐end anastomosis is not feasible beyond a certain length, warranting tissue replacement for reconstruction. 1 Unfortunately, there is no clinical standard for tracheal replacement. Creation of a graft that can recapitulate the complex structure and fu... |
10. 1002/btm2. 10531 | 2,023 | Bioengineering & Translational Medicine | Decellularized squid mantle scaffolds as tissue‐engineered corneal stroma for promoting corneal regeneration | Abstract Corneal blindness is a worldwide major cause of vision loss, and corneal transplantation remains to be the most effective way to restore the vision. However, often there is a shortage of the donor corneas for transplantation. Therefore, it is urgent to develop a novel tissue‐engineered corneal substitute. The ... | 1 INTRODUCTION Blindness has a serious impact on the human health and quality of life. According to the World Health Organization (WHO) report, about 61 million people are expected to go blind by 2050. 1 Corneal damage is the fifth leading cause of blindness in the world, after cataract, refractive error, glaucoma, and... |
10. 1002/btm2. 10534 | 2,023 | Bioengineering & Translational Medicine | Biomimetic in situ tracheal microvascularization for segmental tracheal reconstruction in one‐step | Abstract Formation of functional and perfusable vascular network is critical to ensure the long‐term survival and functionality of the engineered tissue tracheae after transplantation. However, the greatest challenge in tracheal‐replacement therapy is the promotion of tissue regeneration by rapid graft vascularization.... | 1 INTRODUCTION Tracheal transplantation remains an unresolved clinical challenge worldwide. This is primarily owing to the lack of ideal tracheal substitutes and the obstruction of graft vascularization, which is caused by special anatomical structures. 1, 2 Longer segment trachea (more than 50% in adults or 30% in chi... |
10. 1002/btm2. 10535 | 2,023 | Bioengineering & Translational Medicine | Biomimetic scaffold‐based stem cell transplantation promotes lung regeneration | Abstract Therapeutic options are limited for severe lung injury and disease as the spontaneous regeneration of functional alveolar is terminated owing to the weakness of the inherent stem cells and the dyscrasia of the niche. Umbilical cord mesenchymal‐derived stem cells (UC‐MSCs) have been applied to clinical trials t... | 1 INTRODUCTION End‐stage lung disease remains the leading cause of death in the industrialized world owing to the complex nature and slow regeneration capacity of the lungs. 1 Unlike tissues with a rapid renewal capacity, which have well‐defined hierarchies of stem cells and differentiated cells, the mature lung of mam... |
10. 1002/btm2. 10559 | 2,023 | Bioengineering & Translational Medicine | Flourishing tumor organoids: History, emerging technology, and application | Abstract Malignant tumors are one of the leading causes of death which impose an increasingly heavy burden on all countries. Therefore, the establishment of research models that closely resemble original tumor characteristics is crucial to further understanding the mechanisms of malignant tumor development, developing ... | 1 INTRODUCTION Malignant tumors are one of the leading causes of death which impose a significant burden on individual countries worldwide. This burden will gradually increase over time, with the global cancer burden predicted to reach 28. 4 million cases by 2040. 1 Despite some achievements in the diagnosis and treatm... |
10. 1002/btm2. 10562 | 2,023 | Bioengineering & Translational Medicine | Dual gene‐activated dermal scaffolds regulate angiogenesis and wound healing by mediating the coexpression of | Abstract The vascularization of dermal substitutes is a key challenge in efforts to heal deep skin defects. In this study, dual gene‐activated dermal scaffolds (DGADSs‐1) were fabricated by loading nanocomposite particles of polyethylenimine (PEI)/multiple plasmid DNAs (pDNAs) encoding vascular endothelial growth facto... | 1 INTRODUCTION Skin defects triggered by various acute and chronic factors (e. g. , trauma, mechanical injuries, burns, chronic ulcers, and tumor resection) are prevalent in clinical practice 1 ; they greatly affect public health, as well as economic and social development. A dermal substitute is a template for dermal ... |
10. 1002/btm2. 10572 | 2,023 | Bioengineering & Translational Medicine | Histological assessment of nanostructured fibrin‐agarose skin substitutes grafted in burnt patients. A time‐course study | Abstract A previously developed fibrin‐agarose skin model—UGRSKIN—showed promising clinical results in severely burnt patients. To determine the histological parameters associated to the biocompatibility and therapeutic effects of this model, we carried out a comprehensive structural and ultrastructural study of UGRSKI... | 1 INTRODUCTION Large burns are very relevant public health problems causing massive tissue destruction and dramatic pathophysiologic effects on the burnt patient. 1 As an intact healthy skin is necessary to protect the internal tissues, a proper skin barrier is essential for patient survival. 2 However, treatment of th... |
10. 1002/btm2. 10574 | 2,023 | Bioengineering & Translational Medicine | Pluronic F127 “nanoarmor” for stabilization of Cowpea mosaic virus immunotherapy | Abstract Our lab demonstrated that intratumoral Cowpea mosaic virus (CPMV) is a potent antitumor immunotherapy when used as in situ vaccine. As we pave the way for human clinical translation, formulation chemistry needs to be optimized for long‐term storage of the drug candidate. In this work, CPMV was nanoengineered w... | 1 INTRODUCTION Plant viral nanoparticles (VNPs) are naturally evolved nanocarriers of genetic payloads and VNPs have been developed as vaccines and immunotherapy applications capitalizing on their immunomodulatory nature. 1 The viral RNA genome and proteinaceous capsids function as pathogen‐associated molecular pattern... |
10. 1002/btm2. 10581 | 2,023 | Bioengineering & Translational Medicine | The emerging role of heart‐on‐a‐chip systems in delineating mechanisms of | Abstract Coronavirus disease 2019 (COVID‐19) has been a major global health concern since its emergence in 2019, with over 680 million confirmed cases as of April 2023. While COVID‐19 has been strongly associated with the development of cardiovascular complications, the specific mechanisms by which viral infection indu... | Translational Impact Statement The source of cardiac complications associated with COVID‐19 remains a subject of academic debate. In this comprehensive review, we describe potential mechanisms through which SARS‐CoV‐2 induces cardiac dysfunction, placing particular emphasis on recent advancements in heart‐on‐a‐chip sys... |
10. 1002/btm2. 10583 | 2,023 | Bioengineering & Translational Medicine | Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas | Abstract Additive manufacturing techniques allow the customized design of medical devices according to the patient's requirements. Enteroatmospheric fistula is a pathology that benefits from this personalization due to its extensive clinical variability since the size and morphology of the wound differ extensively amon... | Translational Impact Statement Enteroatmospheric fistula is a complex pathology that has an extensive clinical variability, where a gastrointestinal tract is contact with an open abdominal wound. Part of its treatment is based on Negative Pressure Wound Therapy and the wound has to be isolated from the intestinal debit... |
10. 1002/btm2. 10597 | 2,023 | Bioengineering & Translational Medicine | Distinguished biomimetic | Abstract Breast cancer is the most prevalent malignant tumor affecting women's health. Bone is the most common distant metastatic organ, worsening the quality of life and increasing the mortality of patients. Early detection of breast cancer bone metastasis is urgent for halting disease progression and improving tumor ... | Translational Impact Statements Bone is the most frequent organ of breast cancer metastasis. Early diagnosis is crucial for clinical treatment and prognostic survival. Here, we developed a biomimetic decellularized extracellular matrix (dECM) system with bone mimetic niche and bone tumor mimetic niche. The constructed ... |
10. 1002/btm2. 10627 | 2,023 | Bioengineering & Translational Medicine | Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications | Abstract Cellular phenotypes and functional responses are modulated by the signals present in their microenvironment, including extracellular matrix (ECM) proteins, tissue mechanical properties, soluble signals and nutrients, and cell–cell interactions. To better recapitulate and analyze these complex signals within th... | Translational Impact Statement This review explores the spectrum of techniques used for high throughput cell culture and their applications in stem cell differentiation, drug discovery & predictive toxicology, and personalized medicine, along with emerging opportunities. 1 INTRODUCTION There is a pressing need for bett... |
10. 1002/btm2. 10629 | 2,023 | Bioengineering & Translational Medicine | Therapeutic potential of mesenchymal stem cells from human | Abstract Human induced pluripotent stem cells (iPSCs) hold great promise for personalized medicine, as they can be differentiated into specific cell types, especially mesenchymal stem cells (MSCs). Therefore, our study sought to assess the feasibility of deriving MSCs from teratomas generated from human iPSCs. Teratoma... | Translational Impact Statement To overcome the limitations associated with conventional methods for MSCs derivation and differentiation from PSCs, we suggested a novel method to utilize teratomas as a potential source of MSCs. We found condensed MSCs mass inside of the teratomas and isolated iPSCs‐MSCs from the condens... |
10. 1002/btm2. 10633 | 2,023 | Bioengineering & Translational Medicine | Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation | Abstract A multifunctional bioreactor was fabricated in this study to investigate the facilitation efficiency of electrical and mechanical stimulations on myogenic differentiation. This bioreactor consisted of a highly stretchable conductive membrane prepared by depositing polypyrrole (PPy) on a flexible polydimethylsi... | Translational Impact Statement A highly stretchable PPy/PDMS membrane was developed to construct a multifunctional bioreactor, which can mechanically and electrically stimulate C2C12 myoblasts. Both stimuli can upregulate myogenic genes of treated cells, so myo‐differentiation and myotube formation were highly promoted... |
10. 1002/btm2. 10642 | 2,023 | Bioengineering & Translational Medicine | Growth factors and growth factor gene therapies for treating chronic wounds | Abstract Chronic wounds are an unmet clinical need affecting millions of patients globally, and current standards of care fail to consistently promote complete wound closure and prevent recurrence. Disruptions in growth factor signaling, a hallmark of chronic wounds, have led researchers to pursue growth factor therapi... | Translational Impact Statement Chronic wounds persist as a healthcare challenge despite extensive research on various treatments, including growth factors and gene therapies. Progress in translating these therapeutics to clinical use has been slow, with many growth factor approaches demonstrating promise in preclinical... |
10. 1002/btpr. 2591 | 2,017 | Biotechnology progress | Deconvolution of images from 3D printed cells in layers on a chip | Layer-by-layer cell printing is useful in mimicking layered tissue structures inside the human body and has great potential for being a promising tool in the field of tissue engineering, regenerative medicine, and drug discovery. However, imaging human cells cultured in multiple hydrogel layers in 3D-printed tissue con... | No full text available |
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