PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6r9x
1.66
2,019
JW2
A
301
kd
=
1.1
mM
-2.958607
MOAD
Kd=1.1mM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
O=C(NCc1ccccn1)C(=O)NC1CCCC1
247.298
0.7566
71.09
3
18
2
3
0.774472
6ra5
2.9
2,020
JWE
A
401
ic50
=
1,259
nM
-5.899974
BindingDB
IC50=1259nM
Q9UKE5,Q9UKE5
TRAF2 and NCK-interacting protein kinase,TRAF2 and NCK-interacting protein kinase
Nc1ncc(Br)c2ccc(-c3ccnc(F)c3)nc12
319.137
3.1756
64.69
1
19
1
4
0.699794
6ra7
1.2
2,019
JWK
A
403
ic50
=
126
nM
-6.899629
BindingDB
IC50=126nM
Q9UKE5
TRAF2 and NCK-interacting protein kinase
CC(C)(O)c1cnc(N)c2nc(-c3ccnc(F)c3)ccc12
298.321
2.6405
84.92
2
22
2
5
0.710398
6rb1
1.5
2,020
JWQ
A
406
ic50
=
1.37
uM
-5.863279
MOAD
ic50=1.37uM
P68400
Casein kinase II subunit alpha
COc1cc(/C=C(\C#N)C(=O)Nc2nnc(C(F)(F)F)s2)ccc1O
370.312
2.81678
108.13
4
25
2
7
0.632874
6rb5
1.977
2,020
JWZ
A
508
ic50
=
3.5
uM
-5.455932
MOAD
ic50=3.5uM
Q389T8,Q389T8
Trypanothione reductase,Trypanothione reductase
C[N@H+](CCCN1CN(c2ccccc2)[C@]2(CC[N@@H+](CC[C@@H]3CC[C@H]4C[C@@H]3C4(C)C)CC2)C1=O)CC1(O)CCN(C(N)=[NH2+])CC1
610.912
-1.0219
107.51
10
44
5
3
0.172337
6rb5
1.977
2,020
JWZ
A
509
ic50
=
3.5
uM
-5.455932
MOAD
ic50=3.5uM
Q389T8,Q389T8
Trypanothione reductase,Trypanothione reductase
C[N@@H+](CCCN1CN(c2ccccc2)[C@]2(CC[N@@H+](CC[C@@H]3CC[C@H]4C[C@@H]3C4(C)C)CC2)C1=O)CC1(O)CCN(C(N)=[NH2+])CC1
610.912
-1.0219
107.51
10
44
5
3
0.172337
6rb5
1.977
2,020
JWZ
B
507
ic50
=
3.5
uM
-5.455932
MOAD
ic50=3.5uM
Q389T8,Q389T8
Trypanothione reductase,Trypanothione reductase
C[N@@H+](CCCN1CN(c2ccccc2)[C@]2(CC[N@@H+](CC[C@@H]3CC[C@H]4C[C@@H]3C4(C)C)CC2)C1=O)CC1(O)CCN(C(N)=[NH2+])CC1
610.912
-1.0219
107.51
10
44
5
3
0.172337
6rb5
1.977
2,020
JWZ
B
506
ic50
=
3.5
uM
-5.455932
MOAD
ic50=3.5uM
Q389T8,Q389T8
Trypanothione reductase,Trypanothione reductase
C[N@@H+](CCCN1CN(c2ccccc2)[C@]2(CC[N@@H+](CC[C@@H]3CC[C@H]4C[C@@H]3C4(C)C)CC2)C1=O)CC1(O)CCN(C(N)=[NH2+])CC1
610.912
-1.0219
107.51
10
44
5
3
0.172337
6rb6
1.9
2,019
JX2
A
1014
ki
=
501
nM
-6.300162
BindingDB
Ki=501nM
Q8WQX9
Phosphodiesterase
COc1ccc(C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(=O)NCc1ccco1
499.611
4.8076
84.14
5
37
1
5
0.363654
6rb6
1.9
2,019
JX2
B
1012
ki
=
501
nM
-6.300162
BindingDB
Ki=501nM
Q8WQX9
Phosphodiesterase
COc1ccc(C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(=O)NCc1ccco1
499.611
4.8076
84.14
5
37
1
5
0.363654
6rbc
1.77
2,020
JX5
A
817
ic50
=
3.97
nM
-8.401209
MOAD
ic50=3.97nM
Q04609
Glutamate carboxypeptidase 2
O=C([O-])CC[C@H](NC(=O)NC[C@@H](NC(=O)CCCNC(=O)c1ccc(I)cc1)C(=O)[O-])C(=O)[O-]
589.319
-4.0163
219.72
14
34
4
9
0.12251
6rcb
2.05
2,020
JYZ
A
401
ic50
=
0.33
uM
-6.481486
MOAD
ic50=0.33uM
P68400
Casein kinase II subunit alpha
COc1cc(/C=C(\C#N)C(=O)Nc2ccccc2O)ccc1O
310.309
2.65208
102.58
4
23
3
5
0.457498
6rcf
1.1
2,020
K0K
A
201
kd
=
0.32
uM
-6.49485
MOAD
Kd=0.32uM
Q8N8S7
Protein enabled homolog
CC[C@@H]1C=C[C@H]2CCN(C(=O)[C@@H]3CC[C@H]4C=C[C@]5(CCCN5C(=O)[C@H](Cc5ccccc5Cl)NC(C)=O)C(=O)N43)[C@@H]2C(=O)N1CC(=O)[O-]
679.194
0.8218
150.47
8
48
1
7
0.400245
6rcj
1.35
2,020
K0H
A
201
kd
=
0.47
uM
-6.327902
MOAD
Kd=0.47uM
Q8N8S7
Protein enabled homolog
CC[C@@H]1C=C[C@H]2CCN(C(=O)[C@@H]3CC[C@H]4C=C[C@]5(CCCN5C(=O)[C@H](Cc5ccccc5Cl)NC(C)=O)C(=O)N43)[C@@H]2C(=O)N1CC(=O)OC
694.229
2.2449
136.64
8
49
1
7
0.325965
6rcm
1.7
2,020
K0N
A
402
ic50
=
0.36
uM
-6.443697
MOAD
ic50=0.36uM
P68400
Casein kinase II subunit alpha
COc1cc(/C=C(\C#N)C(=O)Nc2nnc(C(C)(C)C)s2)ccc1O
358.423
3.09548
108.13
4
25
2
7
0.642095
6rcy
2.3
2,020
K0T
A
201
kd
=
1.6
uM
-5.79588
MOAD
Kd=1.6uM
Q02790
Peptidyl-prolyl cis-trans isomerase FKBP4
CN(C)c1cccc2c(S(=O)(=O)N3CCCC[C@H]3C(=O)N[C@@H](CCc3ccccc3)C(=O)N[C@@H](CCCNC(N)=[NH2+])C(=O)[O-])cccc12
679.844
-0.7551
202.59
15
48
5
7
0.077799
6rd0
1.9
2,020
K0Q
A
306
ki
=
17.7
uM
-4.752027
MOAD
Ki=17.7uM
P39900
Macrophage metalloelastase
O=C(Cn1cccc(O)c1=O)NCCc1c[nH]c2ccccc12
311.341
1.3941
87.12
5
23
3
4
0.665315
6rfe
1.54
2,020
K0Z
A
403
ic50
=
0.28
uM
-6.552842
MOAD
ic50=0.28uM
P68400
Casein kinase II subunit alpha
COc1cc(/C=C(\C#N)C(=O)Nc2nnc(Br)s2)ccc1O
381.211
2.56048
108.13
4
22
2
7
0.622608
6rff
1.8
2,020
K1B
A
401
ic50
=
0.37
uM
-6.431798
MOAD
ic50=0.37uM
P68400
Casein kinase II subunit alpha
N#C/C(=C\c1ccc(O)c([N+](=O)[O-])c1)C(=O)Nc1nnc(Br)s1
396.182
2.46008
142.04
4
23
2
8
0.34982
6rfi
2.31
2,019
K1H
A
502
ic50
=
0.037
uM
-7.431798
MOAD
ic50=0.037uM
Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
COC(=O)N1CC[NH+]([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
395.487
1.19148
95.58
3
29
2
6
0.810671
6rfi
2.31
2,019
K1H
B
502
ic50
=
0.037
uM
-7.431798
MOAD
ic50=0.037uM
Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
COC(=O)N1CC[NH+]([C@H]2CC[C@H](Nc3ncnc4ccc(C#N)cc34)CC2)CC1
395.487
1.19148
95.58
3
29
2
6
0.810671
6rfj
2.61
2,019
K1E
A
501
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
COC(=O)N1CC[NH+]([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1
505.607
1.25798
138.32
6
37
3
10
0.451815
6rfj
2.61
2,019
K1E
B
502
ic50
=
4
nM
-8.39794
BindingDB
IC50=4.0nM
Q9NWZ3,Q9NWZ3
Interleukin-1 receptor-associated kinase 4,Interleukin-1 receptor-associated kinase 4
COC(=O)N1CC[NH+]([C@H]2CC[C@H](Nc3nc(Nc4cnn(C)c4)nc4ccc(CC#N)nc34)CC2)CC1
505.607
1.25798
138.32
6
37
3
10
0.451815
6rfn
2.29
2,019
K3W
A
1009
ki
=
0.000001
M
-6.102373
MOAD
Ki=7.9e-07M
Q8WQX9
Phosphodiesterase
COc1cccc(NC(=O)C#Cc2cc(C3=NN(C(C)C)C(=O)[C@@H]4CC=CC[C@H]34)ccc2OC)c1
471.557
4.2311
80.23
5
35
1
5
0.522821
6rfn
2.29
2,019
K3W
B
1006
ki
=
0.000001
M
-6.102373
MOAD
Ki=7.9e-07M
Q8WQX9
Phosphodiesterase
COc1cccc(NC(=O)C#Cc2cc(C3=NN(C(C)C)C(=O)[C@@H]4CC=CC[C@H]34)ccc2OC)c1
471.557
4.2311
80.23
5
35
1
5
0.522821
6rfw
2.183
2,019
K1Q
A
1007
ki
=
0.000001
M
-6.102373
MOAD
Ki=7.9e-07M
Q8WQX9,Q8WQX9
Phosphodiesterase,Phosphodiesterase
COc1ccc(C2=NN(C(C)C)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(=O)NCCc1ccccc1F
487.575
4.0818
71
6
36
1
4
0.493121
6rfw
2.183
2,019
K1Q
B
1007
ki
=
0.000001
M
-6.102373
MOAD
Ki=7.9e-07M
Q8WQX9
Phosphodiesterase
COc1ccc(C2=NN(C(C)C)C(=O)[C@@H]3CC=CC[C@H]23)cc1C#CC(=O)NCCc1ccccc1F
487.575
4.0818
71
6
36
1
4
0.493121
6rfz
1.8
2,020
BGC
A
403
kd
=
3.56
mM
-2.44855
MOAD
Kd=3.56mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
180.156
-3.2214
110.38
1
12
5
6
0.290153
6rg1
1.7
2,020
RM4
A
407
ic50
=
332
mM
-0.478862
MOAD
ic50=332.0mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
C[C@@H]1O[C@H](O)[C@H](O)[C@H](O)[C@H]1O
164.157
-2.1938
90.15
0
11
4
5
0.326216
6rg2
1.12
2,020
3MG
A
411
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
401
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
403
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
407
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
410
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
404
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
ZB1
A
405
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
ZB1
A
409
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
A
412
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
405
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
404
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
ZB1
B
401
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
411
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
402
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
407
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
412
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
ZB1
B
403
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
ZB1
B
406
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg2
1.12
2,020
3MG
B
408
kd
=
11.2
mM
-1.950782
MOAD
Kd=11.2mM
Q7N8I8
lectin PLL2 from Photorhabdus laumondii
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rg3
1.32
2,020
K1W
A
303
ki
=
8.1
nM
-8.091515
MOAD
Ki=8.1nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(C(=O)N2CC[NH2+]C[C@H]2Cc2ccccc2)cc1
360.459
-0.0355
97.08
4
25
2
3
0.800831
6rg4
1.25
2,020
K45
A
304
ki
=
5.4
nM
-8.267606
MOAD
Ki=5.4nM
P00918
Carbonic anhydrase 2
C[N@@H+]1CCN(C(=O)c2ccc(S(N)(=O)=O)cc2)C[C@@H]1Cc1ccccc1
374.486
-0.0842
84.91
4
26
2
3
0.784815
6rg5
1.089
2,020
S2O
A
304
kd
=
392,000
nM
-3.406714
BindingDB
Ki=125nM,IC50=3000nM,Kd=392000nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(CCO)cc1
201.247
-0.1312
80.39
3
13
2
3
0.714402
6rgr
1.89
2,020
RM4
A
402
ic50
=
147
mM
-0.832683
MOAD
ic50=147.0mM
C7BLE4
Lectin PHL
C[C@@H]1O[C@H](O)[C@H](O)[C@H](O)[C@H]1O
164.157
-2.1938
90.15
0
11
4
5
0.326216
6rgu
1.75
2,020
3MG
A
401
kd
=
14.1
mM
-1.850781
MOAD
Kd=14.1mM
C7BLE4
Lectin PHL
CO[C@@H]1[C@@H](O)[C@H](O)O[C@H](CO)[C@H]1O
194.183
-2.5673
99.38
2
13
4
6
0.385501
6rh4
0.948
2,020
4NZ
A
308
ic50
=
400
nM
-6.39794
BindingDB
IC50=400nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc([N+](=O)[O-])cc1
202.191
0.2422
103.3
2
13
1
4
0.54754
6rh4
0.948
2,020
4NZ
A
307
ic50
=
400
nM
-6.39794
BindingDB
IC50=400nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc([N+](=O)[O-])cc1
202.191
0.2422
103.3
2
13
1
4
0.54754
6rhj
1.44
2,020
K4H
A
303
ki
=
2.3
nM
-8.638272
MOAD
Ki=2.3nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(C(=O)N2CCC[N@H+](Cc3ccccc3)CC2)cc1
374.486
0.265
84.91
4
26
2
3
0.805385
6rhk
1.44
2,020
K4B
A
302
ki
=
0.6
nM
-9.221849
MOAD
Ki=0.6nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(C(=O)N2CC[N@@H+](Cc3ccccc3)C2)cc1
346.432
-0.1676
84.91
4
24
2
3
0.806236
6rig
0.999
2,020
K4N
A
308
ki
=
80
nM
-7.09691
BindingDB
Ki=80nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(O)cc1
173.193
0.0396
80.39
1
11
2
3
0.628757
6rig
0.999
2,020
K4N
A
307
ki
=
80
nM
-7.09691
BindingDB
Ki=80nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(O)cc1
173.193
0.0396
80.39
1
11
2
3
0.628757
6rih
2.15
2,019
K4T
A
401
kd
=
105
uM
-3.978811
MOAD
Kd=105.0uM
O43175
D-3-phosphoglycerate dehydrogenase
Cn1nc(-c2ccccc2)cc1C(=O)NC1CC1
241.294
1.9793
46.92
3
18
1
3
0.892775
6rih
2.15
2,019
K4T
B
402
kd
=
105
uM
-3.978811
MOAD
Kd=105.0uM
O43175
D-3-phosphoglycerate dehydrogenase
Cn1nc(-c2ccccc2)cc1C(=O)NC1CC1
241.294
1.9793
46.92
3
18
1
3
0.892775
6rir
1.767
2,020
GTP
A
201
kd
=
3.3
uM
-5.481486
MOAD
Kd=3.3uM
P61006,Q969X0
Ras-related protein Rab-8A,RILP-like protein 2
Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
519.149
-4.8637
310.42
8
32
4
18
0.237484
6rir
1.767
2,020
GTP
B
900
kd
=
3.3
uM
-5.481486
MOAD
Kd=3.3uM
P61006
Ras-related protein Rab-8A
Nc1nc2c(ncn2[C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]2O)c(=O)[nH]1
519.149
-4.8637
310.42
8
32
4
18
0.237484
6rj2
2.0
2,019
K52
A
402
ic50
=
0.1
uM
-7
MOAD
ic50=0.1uM
O43175
D-3-phosphoglycerate dehydrogenase
CC(=O)NS(=O)(=O)c1ccc([C@@H](C)NC(=O)c2cc(-c3ccccc3)nn2C)cc1
426.498
2.4029
110.16
6
30
2
6
0.628933
6rj2
2.0
2,019
K52
B
401
ic50
=
0.1
uM
-7
MOAD
ic50=0.1uM
O43175
D-3-phosphoglycerate dehydrogenase
CC(=O)NS(=O)(=O)c1ccc([C@@H](C)NC(=O)c2cc(-c3ccccc3)nn2C)cc1
426.498
2.4029
110.16
6
30
2
6
0.628933
6rj3
1.42
2,019
K58
A
402
ic50
=
0.4
uM
-6.39794
MOAD
ic50=0.4uM
O43175
D-3-phosphoglycerate dehydrogenase
C[C@@H](NC(=O)c1cc(-c2ccccc2)nn1C)c1ccc(C(=O)[O-])cc1
348.382
1.9416
87.05
5
26
1
5
0.763269
6rj3
1.42
2,019
K58
B
402
ic50
=
0.4
uM
-6.39794
MOAD
ic50=0.4uM
O43175
D-3-phosphoglycerate dehydrogenase
C[C@@H](NC(=O)c1cc(-c2ccccc2)nn1C)c1ccc(C(=O)[O-])cc1
348.382
1.9416
87.05
5
26
1
5
0.763269
6rj5
1.89
2,019
K5N
A
402
ic50
=
0.3
uM
-6.522879
MOAD
ic50=0.3uM
O43175
D-3-phosphoglycerate dehydrogenase
C[C@@H](NC(=O)c1cc(-c2ccccc2)nn1C)c1ccc(C(=O)NS(C)(=O)=O)cc1
426.498
2.2675
110.16
6
30
2
6
0.628289
6rj5
1.89
2,019
K5N
B
402
ic50
=
0.3
uM
-6.522879
MOAD
ic50=0.3uM
O43175
D-3-phosphoglycerate dehydrogenase
C[C@@H](NC(=O)c1cc(-c2ccccc2)nn1C)c1ccc(C(=O)NS(C)(=O)=O)cc1
426.498
2.2675
110.16
6
30
2
6
0.628289
6rj6
1.984
2,019
K5K
A
401
ic50
=
2
nM
-8.69897
MOAD
ic50=2.0nM
O43175
D-3-phosphoglycerate dehydrogenase
Cc1cc2c(cc(C(=O)N[C@H](CO)c3ccc(S(=O)(=O)CC(=O)[O-])cc3)n2C)c(Cl)c1Cl
498.364
1.78052
128.53
7
32
2
7
0.51128
6rj6
1.984
2,019
K5K
B
401
ic50
=
2
nM
-8.69897
MOAD
ic50=2.0nM
O43175
D-3-phosphoglycerate dehydrogenase
Cc1cc2c(cc(C(=O)N[C@H](CO)c3ccc(S(=O)(=O)CC(=O)[O-])cc3)n2C)c(Cl)c1Cl
498.364
1.78052
128.53
7
32
2
7
0.51128
6rje
2.5
2,019
K5T
A
601
kd
=
890
uM
-3.05061
MOAD
Kd=890.0uM
P10547
Lysostaphin
C[C@H]([NH3+])C(=O)N[C@H](CCC(=O)N[C@@H](CCCCNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)C[NH3+])C(=O)N[C@H](C)C(=O)[O-])C(N)=O
702.747
-9.9003
371.3
24
49
11
11
0.041943
6rkn
0.959
2,020
FBS
A
304
kd
=
435
nM
-6.361511
BindingDB
Kd=435nM,IC50=203nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1ccc(F)cc1
175.184
0.4731
60.16
1
11
1
2
0.674128
6rkq
1.665
2,020
K75
A
402
ki
=
48
uM
-4.318759
MOAD
Ki=48.0uM
P28720
Queuine tRNA-ribosyltransferase
CC#C[C@H]1NC(N)=[NH+]c2cc3[nH]c(NC)nc3cc21
255.305
-0.701
92.73
1
19
5
4
0.435644
6rkt
1.746
2,020
K7H
A
404
ki
=
17
uM
-4.769551
MOAD
Ki=17.0uM
P28720
Queuine tRNA-ribosyltransferase
CNc1nc2cc3c(cc2[nH]1)[NH+]=C(N)NC3
217.256
-1.2654
92.73
1
16
5
4
0.411835
6rl9
1.0
2,020
SAN
A
304
kd
=
5,550
nM
-5.255707
BindingDB
Ki=240nM,IC50=628nM,Kd=5550nM
P00918
Carbonic anhydrase 2
Nc1ccc(S(N)(=O)=O)cc1
172.209
-0.0838
86.18
1
11
2
3
0.580551
6rl9
1.0
2,020
SAN
A
305
kd
=
5,550
nM
-5.255707
BindingDB
Ki=240nM,IC50=628nM,Kd=5550nM
P00918
Carbonic anhydrase 2
Nc1ccc(S(N)(=O)=O)cc1
172.209
-0.0838
86.18
1
11
2
3
0.580551
6rl9
1.0
2,020
SAN
A
306
kd
=
5,550
nM
-5.255707
BindingDB
Ki=240nM,IC50=628nM,Kd=5550nM
P00918
Carbonic anhydrase 2
Nc1ccc(S(N)(=O)=O)cc1
172.209
-0.0838
86.18
1
11
2
3
0.580551
6rlq
2.53
2,020
K8N
A
701
ic50
=
6.3
nM
-8.200659
BindingDB
IC50=6.3nM
O14744
Protein arginine N-methyltransferase 5
Nc1nc2cc(CC[C@H]3C[C@@H](n4ccc5c(N)ncnc54)[C@H](O)[C@@H]3O)ccc2cc1Br
483.37
2.822
136.1
4
31
4
8
0.35051
6rly
2.2
2,020
K8T
A
307
ki
=
17.5
uM
-4.756962
MOAD
Ki=17.5uM
P39900
Macrophage metalloelastase
O=C(Cn1cccc(O)c1=O)NCCc1ccc(-c2ccccc2)cc1
348.402
2.5798
71.33
6
26
2
4
0.719181
6rmy
1.5
2,020
V14
A
302
kd
=
60
nM
-7.221849
BindingDB
Kd=60nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1c(F)c(F)c(S(=O)(=O)CCO)c(NC2CCCCCCC2)c1F
444.497
2.0421
126.56
6
28
3
6
0.576604
6rna
2.62
2,019
KA2
A
401
ic50
=
0.002
nM
-11.69897
BindingDB
IC50=0.002000nM
O43353
Receptor-interacting serine/threonine-protein kinase 2
CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO
458.565
3.9264
114.3
6
31
2
9
0.44672
6rna
2.62
2,019
KA2
B
401
ic50
=
0.002
nM
-11.69897
BindingDB
IC50=0.002000nM
O43353
Receptor-interacting serine/threonine-protein kinase 2
CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO
458.565
3.9264
114.3
6
31
2
9
0.44672
6rnt
1.8
1,993
2AM
A
105
kd
=
4.3
mM
-2.366532
MOAD
Kd=4.3mM
P00651
RIBONUCLEASE T1
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OP(=O)([O-])[O-]
345.208
-3.127
191.73
4
23
3
12
0.474435
6rof
1.5
2,020
V90
A
304
kd
=
730
nM
-6.136677
BindingDB
Kd=730nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1c(F)c(F)c(SCCO)c(F)c1NC1CCCCCCC1
412.499
3.3605
92.42
6
26
3
5
0.492201
6rot
1.339
2,019
KDQ
H
301
ki
=
483.63
nM
-6.315487
MOAD
Ki=483.63nM
P00734,P00734
Prothrombin,Prothrombin
O=C(NCc1cc(Cl)ccc1CO)[C@@H]1CCCN1C(=O)CNS(=O)(=O)Cc1ccccc1
479.986
1.5591
115.81
9
32
3
5
0.504459
6rpg
2.7
2,019
KDW
B
201
ic50
=
3
nM
-8.522879
BindingDB
IC50=3.0nM,EC50=763nM
Q9NZQ7,Q9NZQ7
Programmed cell death 1 ligand 1,Programmed cell death 1 ligand 1
CC(=O)NCC[NH2+]Cc1cc(C)c(OCc2cccc(-c3cccc(COc4cc(OCc5cncc(C#N)c5)c(C[NH2+]CCNC(C)=O)cc4C)c3C)c2C)cc1OCc1cncc(C#N)c1
917.124
5.83564
201.7
23
68
4
10
0.05667
6rq0
1.6
2,020
KE2
A
403
kd
=
1.1
uM
-5.958607
MOAD
Kd=1.1uM
P9WPP7
Mycocyclosin synthase
Cc1cc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)ccc1O
340.379
1.17462
98.66
4
25
4
4
0.671481
6rq1
1.49
2,020
KE5
A
403
kd
=
39.8
uM
-4.400117
MOAD
Kd=39.8uM
P9WPP7
Mycocyclosin synthase
Cc1cc(O)ccc1C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O
340.379
1.17462
98.66
4
25
4
4
0.671481
6rq3
1.5
2,020
OUC
A
401
kd
>=
100,000
nM
-4
BindingDB
Kd=>100000nM
P9WPP7
Mycocyclosin synthase
Cc1cc(O)cc(C)c1C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O
354.406
1.48304
98.66
4
26
4
4
0.668381
6rq5
1.55
2,020
KEB
A
402
kd
=
15.1
uM
-4.821023
MOAD
Kd=15.1uM
P9WPP7
Mycocyclosin synthase
Cc1cc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)cc(C)c1O
354.406
1.48304
98.66
4
26
4
4
0.668381
6rq6
1.42
2,020
R2H
A
408
kd
=
12.8
uM
-4.89279
MOAD
Kd=12.8uM
P9WPP7
Mycocyclosin synthase
O=C1N[C@@H](Cc2ccc(O)c(F)c2)C(=O)N[C@H]1Cc1ccc(O)cc1
344.342
1.0053
98.66
4
25
4
4
0.665104
6rq8
1.41
2,020
KEH
A
403
kd
=
0.28
uM
-6.552842
MOAD
Kd=0.28uM
P9WPP7
Mycocyclosin synthase
O=C1N[C@@H](Cc2ccc(O)c(I)c2)C(=O)N[C@H]1Cc1ccc(O)cc1
452.248
1.4708
98.66
4
25
4
4
0.528625
6rq9
1.4
2,020
KEQ
A
403
kd
=
10.4
uM
-4.982967
MOAD
Kd=10.4uM
P9WPP7
Mycocyclosin synthase
COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)cc1
340.379
1.1692
87.66
5
25
3
4
0.762397
6rqb
1.459
2,020
Q47
A
404
kd
=
0.46
uM
-6.337242
MOAD
Kd=0.46uM
P9WPP7
Mycocyclosin synthase
O=C1N[C@@H](Cc2ccc(O)c(Br)c2)C(=O)N[C@H]1Cc1ccc(O)cc1
405.248
1.6287
98.66
4
25
4
4
0.621665
6rqd
1.499
2,020
KEW
A
404
kd
=
1.5
uM
-5.823909
MOAD
Kd=1.5uM
P9WPP7
Mycocyclosin synthase
O=C1N[C@@H](Cc2ccc(O)c(Cl)c2)C(=O)N[C@H]1Cc1ccc(O)cc1
360.797
1.5196
98.66
4
25
4
4
0.664031
6rqk
1.85
2,019
MVL
A
501
kd
=
1.6
mM
-2.79588
MOAD
Kd=1.6mM
Q8XNB2
Alpha-1,6-mannosidase
OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)c2nccn21
200.194
-1.8147
98.74
1
14
4
6
0.427842
6rqk
1.85
2,019
MVL
A
502
kd
=
1.6
mM
-2.79588
MOAD
Kd=1.6mM
Q8XNB2
Alpha-1,6-mannosidase
OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)c2nccn21
200.194
-1.8147
98.74
1
14
4
6
0.427842
6rqk
1.85
2,019
MVL
B
502
kd
=
1.6
mM
-2.79588
MOAD
Kd=1.6mM
Q8XNB2
Alpha-1,6-mannosidase
OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)c2nccn21
200.194
-1.8147
98.74
1
14
4
6
0.427842
6rqk
1.85
2,019
MVL
B
501
kd
=
1.6
mM
-2.79588
MOAD
Kd=1.6mM
Q8XNB2
Alpha-1,6-mannosidase
OC[C@@H]1[C@@H](O)[C@H](O)[C@H](O)c2nccn21
200.194
-1.8147
98.74
1
14
4
6
0.427842