PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6qxd
2.317
2,019
JKB
A
303
ic50
=
0.96
uM
-6.017729
MOAD
ic50=0.96uM
B2ZB02
Tyrosinase
O=C(c1ccc([N+](=O)[O-])cc1[N+](=O)[O-])N1CC[NH+](Cc2ccc(F)cc2)CC1
389.363
1.183
111.03
5
28
1
5
0.609842
6qxg
2.08
2,019
UFP
A
401
ki
=
1.1
nM
-8.958607
MOAD
Ki=1.1nM
P04818,P04818
Thymidylate synthase,Thymidylate synthase
O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](COP(=O)([O-])[O-])O2)cc1F
324.157
-2.8306
156.74
4
21
2
9
0.561025
6qxg
2.08
2,019
UFP
B
401
ki
=
1.1
nM
-8.958607
MOAD
Ki=1.1nM
P04818,P04818,P04818
Thymidylate synthase,Thymidylate synthase,Thymidylate synthase
O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](COP(=O)([O-])[O-])O2)cc1F
324.157
-2.8306
156.74
4
21
2
9
0.561025
6qxg
2.08
2,019
UFP
C
401
ki
=
1.1
nM
-8.958607
MOAD
Ki=1.1nM
P04818
Thymidylate synthase
O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](COP(=O)([O-])[O-])O2)cc1F
324.157
-2.8306
156.74
4
21
2
9
0.561025
6qxu
1.2
2,019
JKN
A
1402
ic50
=
7
nM
-8.154902
MOAD
ic50=7.0nM
O95271
Poly [ADP-ribose] polymerase tankyrase-1
CC(C)(O)c1ccc(-c2nc3c(F)cc(F)cc3c(=O)[nH]2)cc1
316.307
3.0957
65.98
2
23
2
3
0.763309
6qyp
2.2
2,019
JL5
A
401
ki
=
46
nM
-7.337242
BindingDB
Ki=46nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
CCc1sc2ncnc(O[C@H](Cc3ccccc3)C(=O)[O-])c2c1-c1cc(N2CC[NH+](C)CC2)c(O)c(Cl)c1C
567.111
2.66282
103.05
8
39
2
8
0.337905
6qz5
2.0
2,019
JLE
A
401
ki
=
1,600
nM
-5.79588
BindingDB
Ki=1600nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
CCc1sc2ncnc(N[C@H](Cc3ccccc3)C(=O)[O-])c2c1-c1cccc2[nH]ccc12
441.536
4.1751
93.73
7
32
2
6
0.395267
6qz6
1.9
2,019
JLE
A
401
ki
=
1,600
nM
-5.79588
BindingDB
Ki=1600nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
CCc1sc2ncnc(N[C@H](Cc3ccccc3)C(=O)[O-])c2c1-c1cccc2[nH]ccc12
441.536
4.1751
93.73
7
32
2
6
0.395267
6qz8
2.15
2,019
JL8
A
401
ki
=
51
nM
-7.29243
BindingDB
Ki=51nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
CCc1sc2ncnc(O[C@H](Cc3ccccc3)C(=O)[O-])c2c1-c1ccc(O)c(Cl)c1C
467.954
4.32812
95.37
7
32
1
7
0.434383
6qzb
2.0
2,019
JLK
A
401
ki
=
2,400
nM
-5.619789
BindingDB
Ki=2400nM
Q07820
Induced myeloid leukemia cell differentiation protein Mcl-1
CCc1sc2ncnc(N[C@H](Cc3ccccc3)C(=O)[O-])c2c1-c1ccccc1C
416.526
4.00222
77.94
7
30
1
6
0.492635
6qzh
2.1
2,019
JLW
A
1502
kd
=
3
nM
-8.522879
MOAD
Kd=3.0nM
null
null
Cc1ccc([C@H](NC2=NS(=O)(=O)N=C2Nc2ccc(C)c(C(=O)N(C)C)c2O)C(C)(C)C)o1
475.571
3.14814
136.6
4
33
3
7
0.577845
6r0h
2.5
2,019
JN2
A
901
ki
=
56.1
uM
-4.251037
MOAD
Ki=56.1uM
P00489
Glycogen phosphorylase, muscle form
O=C(N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1cccc(-c2ccc(F)cc2)c1
377.368
0.0224
119.25
4
27
5
6
0.51269
6r0i
2.4
2,019
JNB
A
901
ki
=
9.7
uM
-5.013228
MOAD
Ki=9.7uM
P00489
Glycogen phosphorylase, muscle form
O=C(N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)c1ccc(-c2ccccc2)cc1
359.378
-0.1167
119.25
4
26
5
6
0.519433
6r0k
1.15
2,019
JNN
A
2004
ic50
=
12
nM
-7.920819
MOAD
ic50=12.0nM
F8W4B7
Histone deacetylase 6
O=C(NCCc1cc(C(=O)NO)no1)c1ccc(Cl)c(Cl)c1
344.154
2.0729
104.46
5
22
3
5
0.568972
6r0s
1.55
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r0s
1.55
2,019
JOH
C
202
ki
>=
40,000
nM
-4.39794
BindingDB
Ki=>40000nM
A4TVL0
Cereblon isoform 4
O=C1C[C@H](N2C(=O)c3cccc([N+](=O)[O-])c3C2=O)C(=O)N1
289.203
-0.3941
126.69
2
21
1
6
0.44833
6r0u
1.7
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r0u
1.7
2,019
JO5
C
202
ki
>=
40,000
nM
-4.39794
BindingDB
Ki=>40000nM
A4TVL0
Cereblon isoform 4
Nc1cccc2c1C(=O)N([C@H]1CC(=O)NC1=O)C2=O
259.221
-0.7201
109.57
1
19
2
5
0.510607
6r11
1.75
2,019
JOB
A
202
ki
=
12
uM
-4.920819
MOAD
Ki=12.0uM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
Nc1ccc2c(c1)C(=O)N([C@H]1CC(=O)NC1=O)C2=O
259.221
-0.7201
109.57
1
19
2
5
0.510607
6r11
1.75
2,019
JOB
B
202
ki
=
12
uM
-4.920819
MOAD
Ki=12.0uM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
Nc1ccc2c(c1)C(=O)N([C@H]1CC(=O)NC1=O)C2=O
259.221
-0.7201
109.57
1
19
2
5
0.510607
6r12
1.74
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r12
1.74
2,019
JOT
B
202
ki
>=
40,000
nM
-4.39794
BindingDB
Ki=>40000nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1C[C@H](NC(=O)Cc2ccccc2)C(=O)N1
232.239
-0.2396
75.27
3
17
2
3
0.706182
6r12
1.74
2,019
EF2
C
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0
Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r13
1.65
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r19
1.45
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r19
1.45
2,019
EF2
C
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0
Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1a
1.54
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1a
1.54
2,019
EF2
B
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1b
2.27000203237
2,019
CH5
A
501
kd
=
3.6
uM
-5.443697
MOAD
Kd=3.6uM
P71619
Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB
C[N+](C)(C)CCO[P@](=O)([O-])OC[C@H](O)CO
257.223
-1.4526
99.05
8
16
2
6
0.407395
6r1b
2.27000203237
2,019
CH5
B
501
kd
=
3.6
uM
-5.443697
MOAD
Kd=3.6uM
P71619,P71619
Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB,Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB
C[N+](C)(C)CCO[P@](=O)([O-])OC[C@H](O)CO
257.223
-1.4526
99.05
8
16
2
6
0.407395
6r1b
2.27000203237
2,019
CH5
C
501
kd
=
3.6
uM
-5.443697
MOAD
Kd=3.6uM
P71619,P71619
Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB,Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB
C[N+](C)(C)CCO[P@@](=O)([O-])OC[C@H](O)CO
257.223
-1.4526
99.05
8
16
2
6
0.407395
6r1b
2.27000203237
2,019
CH5
D
501
kd
=
3.6
uM
-5.443697
MOAD
Kd=3.6uM
P71619
Putative Sn-glycerol-3-phosphate-binding lipoprotein UgpB
C[N+](C)(C)CCO[P@](=O)([O-])OC[C@H](O)CO
257.223
-1.4526
99.05
8
16
2
6
0.407395
6r1c
1.5
2,019
EF2
A
203
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1c
1.5
2,019
JOW
B
202
ki
=
12,000
nM
-4.920819
BindingDB
Ki=12000nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C([O-])CCC(=O)NCc1ccc(COC(=O)N[C@H]2CC(=O)NC2=O)cc1
376.345
-1.5258
153.73
8
27
3
7
0.465315
6r1c
1.5
2,019
EF2
C
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0
Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1d
1.1
2,019
JP5
A
202
ki
=
4
uM
-5.39794
MOAD
Ki=4.0uM
A4TVL0
Cereblon isoform 4
O=C1C[C@H](NC(=O)OCc2ccccc2)C(=O)N1
248.238
0.3279
84.5
3
18
2
4
0.754729
6r1d
1.1
2,019
JP5
B
202
ki
=
4
uM
-5.39794
MOAD
Ki=4.0uM
A4TVL0
Cereblon isoform 4
O=C1C[C@H](NC(=O)OCc2ccccc2)C(=O)N1
248.238
0.3279
84.5
3
18
2
4
0.754729
6r1k
1.94
2,019
JPB
A
202
ki
=
9
uM
-5.045757
MOAD
Ki=9.0uM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1C[C@H](NC(=O)c2c(Cl)cc(Cl)cc2Cl)C(=O)N1
321.547
1.7917
75.27
2
19
2
3
0.815548
6r1k
1.94
2,019
JPB
B
203
ki
=
9
uM
-5.045757
MOAD
Ki=9.0uM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1C[C@H](NC(=O)c2c(Cl)cc(Cl)cc2Cl)C(=O)N1
321.547
1.7917
75.27
2
19
2
3
0.815548
6r1k
1.94
2,019
JPB
B
202
ki
=
9
uM
-5.045757
MOAD
Ki=9.0uM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1C[C@H](NC(=O)c2c(Cl)cc(Cl)cc2Cl)C(=O)N1
321.547
1.7917
75.27
2
19
2
3
0.815548
6r1k
1.94
2,019
JPB
C
202
ki
=
9
uM
-5.045757
MOAD
Ki=9.0uM
A4TVL0
Cereblon isoform 4
O=C1C[C@H](NC(=O)c2c(Cl)cc(Cl)cc2Cl)C(=O)N1
321.547
1.7917
75.27
2
19
2
3
0.815548
6r1m
1.5
2,020
SSA
A
501
ic50
=
0.21
uM
-6.677781
MOAD
ic50=0.21uM
P0A8L1,P0A8L1
Serine--tRNA ligase,Serine--tRNA ligase
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CO)[C@@H](O)[C@H]1O
434.411
-4.9919
239.65
7
29
6
13
0.23995
6r1m
1.5
2,020
SSA
B
501
ic50
=
0.21
uM
-6.677781
MOAD
ic50=0.21uM
P0A8L1,P0A8L1
Serine--tRNA ligase,Serine--tRNA ligase
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CO)[C@@H](O)[C@H]1O
434.411
-4.9919
239.65
7
29
6
13
0.23995
6r1n
2.03
2,020
SSA
A
501
ic50
=
0.23
uM
-6.638272
MOAD
ic50=0.23uM
P95689
Serine--tRNA ligase
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CO)[C@@H](O)[C@H]1O
434.411
-4.9919
239.65
7
29
6
13
0.23995
6r1o
2.6
2,020
JPE
A
501
kd
=
290
nM
-6.537602
BindingDB
Kd=290nM,IC50=6650nM
P0A8L1
Serine--tRNA ligase
Nc1nc(-c2cccnc2)nc2c1ncn2[C@@H]1O[C@H](COS(=O)(=O)NC(=O)[C@@H]([NH3+])CO)[C@@H](O)[C@H]1O
511.497
-3.9299
252.54
8
35
6
14
0.169085
6r1w
1.35
2,019
EF2
A
202
ki
=
4,400
nM
-5.356547
BindingDB
Ki=4400nM,IC50=7800nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
258.233
0.0878
83.55
1
19
1
4
0.723359
6r1x
1.8
2,019
JPQ
A
202
ki
>=
40,000
nM
-4.39794
BindingDB
Ki=>40000nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
CC(C)=CC(=O)N[C@H]1CC(=O)NC1=O
196.206
-0.5161
75.27
2
14
2
3
0.460835
6r1x
1.8
2,019
JPQ
B
202
ki
>=
40,000
nM
-4.39794
BindingDB
Ki=>40000nM
A4TVL0,A4TVL0
Cereblon isoform 4,Cereblon isoform 4
CC(C)=CC(=O)N[C@H]1CC(=O)NC1=O
196.206
-0.5161
75.27
2
14
2
3
0.460835
6r2c
2.09
2,019
JQ5
A
2004
ki
=
0.88
mM
-3.055517
MOAD
Ki=0.88mM
A0R2B1,A0R2B1
Multifunctional 2-oxoglutarate metabolism enzyme,Multifunctional 2-oxoglutarate metabolism enzyme
CCO[P@@](=O)([O-])C(=O)CCC(=O)[O-]
208.106
-1.367
106.56
6
13
0
6
0.498321
6r2c
2.09
2,019
JQ5
B
2004
ki
=
0.88
mM
-3.055517
MOAD
Ki=0.88mM
A0R2B1,A0R2B1
Multifunctional 2-oxoglutarate metabolism enzyme,Multifunctional 2-oxoglutarate metabolism enzyme
CCO[P@@](=O)([O-])C(=O)CCC(=O)[O-]
208.106
-1.367
106.56
6
13
0
6
0.498321
6r2c
2.09
2,019
JQ5
C
2004
ki
=
0.88
mM
-3.055517
MOAD
Ki=0.88mM
A0R2B1,A0R2B1
Multifunctional 2-oxoglutarate metabolism enzyme,Multifunctional 2-oxoglutarate metabolism enzyme
CCO[P@](=O)([O-])C(=O)CCC(=O)[O-]
208.106
-1.367
106.56
6
13
0
6
0.498321
6r2c
2.09
2,019
JQ5
D
2004
ki
=
0.88
mM
-3.055517
MOAD
Ki=0.88mM
A0R2B1,A0R2B1
Multifunctional 2-oxoglutarate metabolism enzyme,Multifunctional 2-oxoglutarate metabolism enzyme
CCO[P@](=O)([O-])C(=O)CCC(=O)[O-]
208.106
-1.367
106.56
6
13
0
6
0.498321
6r2u
2.49
2,019
11D
A
305
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311
Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
B
301
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
B
306
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
B
305
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311
Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
C
301
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
D
301
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
E
301
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r2u
2.49
2,019
11D
F
301
kd
=
0.51
uM
-6.29243
MOAD
Kd=0.51uM
P25311,P25311
Zinc-alpha-2-glycoprotein,Zinc-alpha-2-glycoprotein
CN(C)c1cccc2c(S(=O)(=O)NCCCCCCCCCCC(=O)[O-])cccc12
433.594
3.4449
89.54
14
30
1
5
0.461051
6r3k
2.2
2,019
JQT
B
201
ic50
=
1.85
nM
-8.732828
BindingDB
IC50=1.85nM
Q9NZQ7,Q9NZQ7,Q9NZQ7
Programmed cell death 1 ligand 1,Programmed cell death 1 ligand 1,Programmed cell death 1 ligand 1
Cc1c(COc2cc(OCc3cccc(C#N)c3)c(C[N@@H+]3C[C@H](O)C[C@H]3C(=O)[O-])cc2Cl)cccc1-c1ccc2c(c1)OCCO2
641.12
3.3843
125.51
10
46
2
8
0.270363
6r3k
2.2
2,019
JQT
D
201
ic50
=
1.85
nM
-8.732828
BindingDB
IC50=1.85nM
Q9NZQ7,Q9NZQ7,Q9NZQ7
Programmed cell death 1 ligand 1,Programmed cell death 1 ligand 1,Programmed cell death 1 ligand 1
Cc1c(COc2cc(OCc3cccc(C#N)c3)c(C[N@H+]3C[C@H](O)C[C@H]3C(=O)[O-])cc2Cl)cccc1-c1ccc2c(c1)OCCO2
641.12
3.3843
125.51
10
46
2
8
0.270363
6r3s
2.19
2,020
JRE
A
501
ic50
=
910
nM
-6.040959
MOAD
ic50=910.0nM
P49336
Cyclin-dependent kinase 8
C[C@H](O)c1c(Cl)cncc1-c1cnc2c(c1)CCCN2C(N)=O
332.791
2.6816
92.34
2
23
2
4
0.883885
6r4k
2.13
2,019
JSK
A
501
ki
=
51
uM
-4.29243
MOAD
Ki=51.0uM
P22073,P22073
Beta-glucosidase A,Beta-glucosidase A
N=NNCCOCCOc1ccc(-c2cn(C[C@@H]3[NH2+]C[C@@H](O)[C@H]3O)nn2)cc1
392.44
-1.45653
154.48
11
28
5
9
0.177863
6r4k
2.13
2,019
JSK
B
501
ki
=
51
uM
-4.29243
MOAD
Ki=51.0uM
P22073,P22073
Beta-glucosidase A,Beta-glucosidase A
N=NNCCOCCOc1ccc(-c2cn(C[C@@H]3[NH2+]C[C@@H](O)[C@H]3O)nn2)cc1
392.44
-1.45653
154.48
11
28
5
9
0.177863
6r5n
2.0
2,020
NOJ
A
802
ki
=
4.4
mM
-2.356547
MOAD
Ki=4.4mM
Q9I311,Q9I311
Periplasmic beta-glucosidase,Periplasmic beta-glucosidase
OC[C@H]1[NH2+]C[C@H](O)[C@@H](O)[C@@H]1O
164.181
-3.993
97.53
1
11
5
4
0.272743
6r5n
2.0
2,020
NOJ
B
802
ki
=
4.4
mM
-2.356547
MOAD
Ki=4.4mM
Q9I311,Q9I311
Periplasmic beta-glucosidase,Periplasmic beta-glucosidase
OC[C@H]1[NH2+]C[C@H](O)[C@@H](O)[C@@H]1O
164.181
-3.993
97.53
1
11
5
4
0.272743
6r6f
1.2
2,019
EA3
A
302
kd
=
10
nM
-8
BindingDB
Kd=10.0nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl
392.93
2.1343
109.49
6
24
3
5
0.686548
6r6j
1.55
2,020
JTW
A
304
kd
=
0.12
nM
-9.920819
MOAD
Kd=0.12nM
P00918
Carbonic anhydrase 2
NS(=O)(=O)c1cc(C(=O)NCCO)c(S(=O)(=O)c2ccccc2)cc1Cl
418.88
0.5423
143.63
6
26
3
6
0.624174
6r6y
1.38
2,020
EA3
A
305
kd
=
0.008
nM
-11.09691
MOAD
Kd=0.008nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl
392.93
2.1343
109.49
6
24
3
5
0.686548
6r6y
1.38
2,020
EA3
B
305
kd
=
0.008
nM
-11.09691
MOAD
Kd=0.008nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl
392.93
2.1343
109.49
6
24
3
5
0.686548
6r6y
1.38
2,020
EA3
C
305
kd
=
0.008
nM
-11.09691
MOAD
Kd=0.008nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl
392.93
2.1343
109.49
6
24
3
5
0.686548
6r6y
1.38
2,020
EA3
D
303
kd
=
0.008
nM
-11.09691
MOAD
Kd=0.008nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(SC2CCCCC2)cc1Cl
392.93
2.1343
109.49
6
24
3
5
0.686548
6r71
2.0
2,020
JTW
A
303
kd
=
0.12
nM
-9.920819
MOAD
Kd=0.12nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(S(=O)(=O)c2ccccc2)cc1Cl
418.88
0.5423
143.63
6
26
3
6
0.624174
6r71
2.0
2,020
JTW
B
302
kd
=
0.12
nM
-9.920819
MOAD
Kd=0.12nM
O43570
Carbonic anhydrase 12
NS(=O)(=O)c1cc(C(=O)NCCO)c(S(=O)(=O)c2ccccc2)cc1Cl
418.88
0.5423
143.63
6
26
3
6
0.624174
6r7d
2.35
2,019
JUQ
A
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
B
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
C
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
D
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
E
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
F
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
G
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
H
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
I
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
J
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
K
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7d
2.35
2,019
JUQ
L
201
ic50
=
2.4
nM
-8.619789
MOAD
ic50=2.4nM
Q16873,Q16873
Leukotriene C4 synthase,Leukotriene C4 synthase
COc1nc(C(=O)[C@H]2C[C@@H]2C(=O)[O-])ncc1N(CC1CC1)c1cccc2ccccc12
416.457
2.7552
95.45
8
31
0
7
0.521127
6r7j
1.84
2,019
JUN
A
601
ic50
=
0
M
-8
MOAD
ic50=1e-08M
P51449
Nuclear receptor ROR-gamma
CCS(=O)(=O)c1ccc([C@@H](NC(C)=O)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)cc1
526.455
3.6083
112.57
7
35
3
5
0.477597
6r7k
1.54
2,019
JUH
A
601
ic50
=
0
M
-8
MOAD
ic50=1e-08M
P51449
Nuclear receptor ROR-gamma
CCS(=O)(=O)c1ccc([C@@H](NC(=O)Cc2ccccc2)C(=O)Nc2ccc(C(O)(C(F)(F)F)C(F)(F)F)cc2)cc1
602.553
4.8311
112.57
9
41
3
5
0.304017
6r8g
2.0
2,020
NAD
C
401
kd
=
172
uM
-3.764472
MOAD
Kd=172.0uM
Q6VVP7,Q6VVP7
Malate dehydrogenase,Malate dehydrogenase
NC(=O)c1ccc[n+]([C@@H]2O[C@H](CO[P@](=O)([O-])O[P@](=O)([O-])OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1
662.422
-4.2799
323.92
11
44
6
19
0.083532
6r8l
1.64
2,019
JUZ
A
301
kd
=
0.006
uM
-8.221849
MOAD
Kd=0.006uM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
CSc1ccccc1[C@H]1CCCN1C(=O)CNC(=O)NCc1ccc2c(c1)[C@@H]1C[C@H](N2)[C@H](O)CO1
496.633
3.1878
102.93
6
35
4
6
0.458344
6r8o
1.36
2,019
JV2
A
304
kd
=
0.67
uM
-6.173925
MOAD
Kd=0.67uM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
CSc1ccccc1[C@H]1CCCN1C(=O)CNC(=O)NCc1ccc2c(c1)[C@H]1C[C@@H](N2)[C@H](O)CO1
496.633
3.1878
102.93
6
35
4
6
0.458344
6r8p
1.45
2,019
JVB
A
517
ic50
=
33
uM
-4.481486
MOAD
ic50=33.0uM
Q6P988
Palmitoleoyl-protein carboxylesterase NOTUM
Cc1ccccc1OCC(=O)Nc1cccnc1
242.278
2.40752
51.22
4
18
1
3
0.895282
6r8q
1.5
2,019
JV5
A
515
ic50
=
0.12
uM
-6.920819
MOAD
ic50=0.12uM
Q6P988
Palmitoleoyl-protein carboxylesterase NOTUM
Cc1ccccc1OCC(=O)Nc1ccc2[nH]nnc2c1
282.303
2.28382
79.9
4
21
2
4
0.769042
6r8r
1.27
2,019
JV8
A
502
ic50
=
0.085
uM
-7.070581
MOAD
ic50=0.085uM
Q6P988
Palmitoleoyl-protein carboxylesterase NOTUM
Cc1ccccc1OCC(=O)Nc1ccc2cnccc2c1
292.338
3.56072
51.22
4
22
1
3
0.799596
6r8w
1.4
2,019
JVH
A
303
kd
=
1.2
uM
-5.920819
MOAD
Kd=1.2uM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
O=C(CN1C(=O)[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C1=O)NCc1ccc2c(c1)[C@H]1C[C@@H](N2)[C@H](O)CO1
425.485
0.9503
107.97
4
31
3
6
0.620274
6r9s
2.0
2,019
JVN
A
302
kd
=
7.1
mM
-2.148742
MOAD
Kd=7.1mM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
O[C@@H]1CO[C@@H]2C[C@H]1Nc1ccc(F)cc12
209.22
1.4421
41.49
0
15
2
3
0.679024
6r9s
2.0
2,019
JVN
A
301
kd
=
7.1
mM
-2.148742
MOAD
Kd=7.1mM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
O[C@@H]1CO[C@@H]2C[C@H]1Nc1ccc(F)cc12
209.22
1.4421
41.49
0
15
2
3
0.679024
6r9u
1.26
2,019
JVQ
A
301
kd
=
7.5
mM
-2.124939
MOAD
Kd=7.5mM
P30405
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
CCN1Cc2cc3c(cc2NCCC1=O)OCO3
248.282
1.5794
50.8
1
18
1
4
0.819459
6r9w
1.75
2,019
JVZ
A
301
ic50
=
0.22
uM
-6.657577
MOAD
ic50=0.22uM
P9WGR1
Enoyl-[acyl-carrier-protein] reductase [NADH]
O[C@H](COc1ccc2c(c1)CCC2)Cn1cnc2ccccc21
308.381
2.9649
47.28
5
23
1
4
0.78807