PDBID
stringlengths
4
4
Resolution
stringlengths
1
13
Year
int64
1.98k
2.02k
Ligand Name
stringlengths
1
7
Ligand Chain
stringclasses
53 values
Ligand Residue Number
stringlengths
1
9
Binding Affinity Measurement
stringclasses
4 values
Binding Affinity Sign
stringclasses
6 values
Binding Affinity Value
float64
0
500M
Binding Affinity Unit
stringclasses
6 values
Log Binding Affinity
float64
-14
2.97
Binding Affinity Source
stringclasses
3 values
Binding Affinity Annotation
stringlengths
6
72
Protein UniProtID
stringlengths
6
55
Protein UniProtName
stringlengths
2
575
Ligand SMILES
stringlengths
4
352
Ligand MW
float64
44
1.82k
Ligand LogP
float64
-23.01
13.7
Ligand TPSA
float64
0
786
Ligand NumRotBond
int64
0
59
Ligand NumHeavyAtoms
int64
3
120
Ligand NumHDon
int64
0
30
Ligand NumHAcc
int64
0
56
Ligand QED
float64
0.01
0.95
6qmr
2.0
2,019
J6T
D
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162
6qmr
2.0
2,019
J6T
E
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162
6qmr
2.0
2,019
J6T
F
301
ic50
=
0.012
uM
-7.920819
MOAD
ic50=0.012uM
P00746
Complement factor D
[NH3+][C@H](CO)c1cccc(-c2cccc(COc3ccccc3CC(=O)[O-])c2)c1
377.44
1.5003
97.23
8
28
2
4
0.62162
6qmt
1.8
2,019
J7B
A
301
ic50
=
0.12
uM
-6.920819
MOAD
ic50=0.12uM
P00746
Complement factor D
[NH3+]Cc1cccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)[O-])c2)c1
360.413
1.6402
96.87
6
27
2
3
0.699218
6qmt
1.8
2,019
J7B
B
301
ic50
=
0.12
uM
-6.920819
MOAD
ic50=0.12uM
P00746
Complement factor D
[NH3+]Cc1cccc(-c2cccc(C(=O)Nc3ccccc3CC(=O)[O-])c2)c1
360.413
1.6402
96.87
6
27
2
3
0.699218
6qn0
1.89
2,020
J8Q
A
302
kd
=
0.003
nM
-11.522879
BindingDB
Kd=0.003000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn0
1.89
2,020
J8Q
B
302
kd
=
0.003
nM
-11.522879
BindingDB
Kd=0.003000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn0
1.89
2,020
J8Q
C
302
kd
=
0.003
nM
-11.522879
BindingDB
Kd=0.003000nM
O43570,O43570
Carbonic anhydrase 12,Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn0
1.89
2,020
J8Q
D
302
kd
=
0.003
nM
-11.522879
BindingDB
Kd=0.003000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn2
1.95
2,020
J92
A
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qn2
1.95
2,020
J92
B
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qn2
1.95
2,020
J92
C
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qn2
1.95
2,020
J92
D
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9,Carbonic anhydrase 9
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qn5
1.96
2,020
J8N
A
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qn5
1.96
2,020
J8N
B
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qn5
1.96
2,020
J8N
C
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790
Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qn5
1.96
2,020
J8N
D
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qn6
2.25
2,020
J8Q
A
302
kd
=
1.3
nM
-8.886057
BindingDB
Kd=1.3nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn6
2.25
2,020
J8Q
B
302
kd
=
1.3
nM
-8.886057
BindingDB
Kd=1.3nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn6
2.25
2,020
J8Q
C
302
kd
=
1.3
nM
-8.886057
BindingDB
Kd=1.3nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qn6
2.25
2,020
J8Q
D
302
kd
=
1.3
nM
-8.886057
BindingDB
Kd=1.3nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SCCc1ccccc1
426.991
3.8521
89.26
9
27
2
4
0.470358
6qng
1.67
2,020
J95
A
302
kd
=
10,000
nM
-5
BindingDB
Kd=10000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NC1CCCCC1
387.933
3.2619
101.29
7
25
3
4
0.624653
6qng
1.67
2,020
J95
B
302
kd
=
10,000
nM
-5
BindingDB
Kd=10000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NC1CCCCC1
387.933
3.2619
101.29
7
25
3
4
0.624653
6qng
1.67
2,020
J95
C
302
kd
=
10,000
nM
-5
BindingDB
Kd=10000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NC1CCCCC1
387.933
3.2619
101.29
7
25
3
4
0.624653
6qng
1.67
2,020
J95
D
302
kd
=
10,000
nM
-5
BindingDB
Kd=10000nM
O43570
Carbonic anhydrase 12
CCCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1NC1CCCCC1
387.933
3.2619
101.29
7
25
3
4
0.624653
6qnl
1.53
2,020
J92
A
302
kd
=
0.005
nM
-11.30103
BindingDB
Kd=0.005000nM
O43570
Carbonic anhydrase 12
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qnl
1.53
2,020
J92
B
302
kd
=
0.005
nM
-11.30103
BindingDB
Kd=0.005000nM
O43570
Carbonic anhydrase 12
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qnl
1.53
2,020
J92
C
302
kd
=
0.005
nM
-11.30103
BindingDB
Kd=0.005000nM
O43570
Carbonic anhydrase 12
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qnl
1.53
2,020
J92
D
302
kd
=
0.005
nM
-11.30103
BindingDB
Kd=0.005000nM
O43570
Carbonic anhydrase 12
COC(=O)CCCNC(=O)c1cc(S(N)(=O)=O)c(Cl)cc1SC1CCCCC1
448.994
3.0952
115.56
8
28
2
6
0.46596
6qot
1.62
2,020
6SD
A
301
kd
=
0.17
mM
-3.769551
MOAD
Kd=0.17mM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1ccc(-c2cc(N)[nH]n2)cc1
189.218
1.6675
63.93
2
14
2
3
0.754795
6qot
1.62
2,020
6SD
B
301
kd
=
0.17
mM
-3.769551
MOAD
Kd=0.17mM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1ccc(-c2cc(N)[nH]n2)cc1
189.218
1.6675
63.93
2
14
2
3
0.754795
6qp0
2.409
2,019
ADP
A
501
kd
=
1
uM
-6
MOAD
Kd=1.0uM
G0SHI1
Putative chromatin binding protein
Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)([O-])OP(=O)([O-])[O-])[C@@H](O)[C@H]1O
424.179
-3.642
241.09
6
27
3
15
0.378904
6qqq
1.85
2,019
JDE
A
301
kd
=
6.7
uM
-5.173925
MOAD
Kd=6.7uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cc(COC(=O)c2cn[nH]c2)cc(-c2cccnc2)c1
309.325
2.8373
77.1
5
23
1
5
0.733312
6qqq
1.85
2,019
JDE
B
302
kd
=
6.7
uM
-5.173925
MOAD
Kd=6.7uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cc(COC(=O)c2cn[nH]c2)cc(-c2cccnc2)c1
309.325
2.8373
77.1
5
23
1
5
0.733312
6qqs
1.76
2,020
JCZ
A
301
kd
=
110
uM
-3.958607
MOAD
Kd=110.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3cc[nH]c3c2)n[nH]1
198.229
2.1402
70.49
1
15
3
2
0.560243
6qqs
1.76
2,020
JCZ
B
301
kd
=
110
uM
-3.958607
MOAD
Kd=110.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3cc[nH]c3c2)n[nH]1
198.229
2.1402
70.49
1
15
3
2
0.560243
6qqt
1.673
2,019
JCH
A
301
kd
=
59
uM
-4.229148
MOAD
Kd=59.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1ccc(Cn2ccc3ccc(-c4cc(N)[nH]n4)cc32)cc1
318.38
3.6705
68.86
4
24
2
4
0.603009
6qqt
1.673
2,019
JCH
B
301
kd
=
59
uM
-4.229148
MOAD
Kd=59.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1ccc(Cn2ccc3ccc(-c4cc(N)[nH]n4)cc32)cc1
318.38
3.6705
68.86
4
24
2
4
0.603009
6qqu
1.59
2,019
JF8
A
301
kd
=
5
uM
-5.30103
MOAD
Kd=5.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3cc[nH]c3c2)n[nH]c1N
223.239
2.01188
94.28
1
17
3
3
0.588536
6qqu
1.59
2,019
JF8
B
301
kd
=
5
uM
-5.30103
MOAD
Kd=5.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3cc[nH]c3c2)n[nH]c1N
223.239
2.01188
94.28
1
17
3
3
0.588536
6qqv
1.712
2,019
JEW
A
301
kd
=
12
uM
-4.920819
MOAD
Kd=12.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1ccccc1Cn1ccc2ccc(-c3cc(N)[nH]n3)cc21
313.364
3.53358
83.42
3
24
2
4
0.606603
6qqv
1.712
2,019
JEW
B
303
kd
=
12
uM
-4.920819
MOAD
Kd=12.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1ccccc1Cn1ccc2ccc(-c3cc(N)[nH]n3)cc21
313.364
3.53358
83.42
3
24
2
4
0.606603
6qqw
1.8
2,019
JDQ
A
301
kd
=
19
uM
-4.721246
MOAD
Kd=19.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccccc4)c3c2)n[nH]1
288.354
3.6619
59.63
3
22
2
3
0.604102
6qqw
1.8
2,019
JDQ
B
301
kd
=
19
uM
-4.721246
MOAD
Kd=19.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccccc4)c3c2)n[nH]1
288.354
3.6619
59.63
3
22
2
3
0.604102
6qqy
1.49
2,020
JD2
A
301
kd
=
0.5
uM
-6.30103
MOAD
Kd=0.5uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccccn4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qqy
1.49
2,020
JD2
B
301
kd
=
0.5
uM
-6.30103
MOAD
Kd=0.5uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccccn4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qqz
1.702
2,019
JEB
A
301
kd
=
0.18
uM
-6.744727
MOAD
Kd=0.18uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4cccnc4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qqz
1.702
2,019
JEB
B
301
kd
=
0.18
uM
-6.744727
MOAD
Kd=0.18uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4cccnc4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qr0
1.59
2,019
JFB
A
301
kd
=
0.12
uM
-6.920819
MOAD
Kd=0.12uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccncc4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qr0
1.59
2,019
JFB
B
301
kd
=
0.12
uM
-6.920819
MOAD
Kd=0.12uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccncc4)c3c2)n[nH]c1N
314.352
2.92858
96.31
3
24
2
5
0.607367
6qr1
1.67
2,019
JFT
A
301
kd
=
8.5
uM
-5.070581
MOAD
Kd=8.5uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(N)n[nH]c1-c1ccc2c(Cl)cn(Cc3cccnc3)c2c1
348.797
3.58198
96.31
3
25
2
5
0.590999
6qr1
1.67
2,019
JFT
B
301
kd
=
8.5
uM
-5.070581
MOAD
Kd=8.5uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(N)n[nH]c1-c1ccc2c(Cl)cn(Cc3cccnc3)c2c1
348.797
3.58198
96.31
3
25
2
5
0.590999
6qr2
1.55
2,019
JQB
A
301
kd
=
3.2
uM
-5.49485
MOAD
Kd=3.2uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc[nH]c4=O)c3c2)n[nH]c1N
330.351
2.22188
116.28
3
25
3
5
0.533749
6qr2
1.55
2,019
JQB
B
301
kd
=
3.2
uM
-5.49485
MOAD
Kd=3.2uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc[nH]c4=O)c3c2)n[nH]c1N
330.351
2.22188
116.28
3
25
3
5
0.533749
6qr3
1.614
2,019
JE8
A
301
kd
=
0.36
uM
-6.443697
MOAD
Kd=0.36uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[N@@H+]1CCC[C@H](Cn2ccc3ccc(-c4n[nH]c(N)c4C#N)cc32)C1
335.435
1.40998
87.86
3
25
3
4
0.676116
6qr3
1.614
2,019
JE8
B
301
kd
=
0.36
uM
-6.443697
MOAD
Kd=0.36uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[N@@H+]1CCC[C@H](Cn2ccc3ccc(-c4n[nH]c(N)c4C#N)cc32)C1
335.435
1.40998
87.86
3
25
3
4
0.676116
6qr4
1.52
2,019
JD8
A
301
kd
=
0.59
uM
-6.229148
MOAD
Kd=0.59uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[N@@H+]1CCCC[C@@H]1Cn1ccc2ccc(-c3n[nH]c(N)c3C#N)cc21
335.435
1.55248
87.86
3
25
3
4
0.678496
6qr4
1.52
2,019
JD8
B
301
kd
=
0.59
uM
-6.229148
MOAD
Kd=0.59uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[N@@H+]1CCCC[C@@H]1Cn1ccc2ccc(-c3n[nH]c(N)c3C#N)cc21
335.435
1.55248
87.86
3
25
3
4
0.678496
6qr5
1.81
2,020
JFH
A
301
kd
=
0.49
uM
-6.309804
MOAD
Kd=0.49uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCC5)cc4)c3c2)n[nH]1
372.496
2.8406
64.07
5
28
3
3
0.50438
6qr5
1.81
2,020
JFH
B
301
kd
=
0.49
uM
-6.309804
MOAD
Kd=0.49uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCC5)cc4)c3c2)n[nH]1
372.496
2.8406
64.07
5
28
3
3
0.50438
6qr6
1.71
2,020
JCK
A
301
kd
=
0.027
uM
-7.568636
MOAD
Kd=0.027uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCC5)cc4)c3c2)n[nH]c1N
397.506
2.71228
87.86
5
30
3
4
0.48382
6qr6
1.71
2,020
JCK
B
301
kd
=
0.027
uM
-7.568636
MOAD
Kd=0.027uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCC5)cc4)c3c2)n[nH]c1N
397.506
2.71228
87.86
5
30
3
4
0.48382
6qr7
2.03
2,019
JEK
A
301
kd
=
70
nM
-7.154902
MOAD
Kd=70.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCCC5)cc4)c3c2)n[nH]c1N
411.533
3.10238
87.86
5
31
3
4
0.471519
6qr7
2.03
2,019
JEK
B
301
kd
=
70
nM
-7.154902
MOAD
Kd=70.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCCC5)cc4)c3c2)n[nH]c1N
411.533
3.10238
87.86
5
31
3
4
0.471519
6qr8
2.15
2,020
JDH
A
301
kd
=
0.073
uM
-7.136677
MOAD
Kd=0.073uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[NH+]1CCN(Cc2ccc(Cn3ccc4ccc(-c5n[nH]c(N)c5C#N)cc43)cc2)CC1
426.548
1.86388
91.1
5
32
3
5
0.454369
6qr8
2.15
2,020
JDH
B
301
kd
=
0.073
uM
-7.136677
MOAD
Kd=0.073uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
C[NH+]1CCN(Cc2ccc(Cn3ccc4ccc(-c5n[nH]c(N)c5C#N)cc43)cc2)CC1
426.548
1.86388
91.1
5
32
3
5
0.454369
6qr9
2.42
2,019
JEE
A
301
kd
=
190
nM
-6.721246
MOAD
Kd=190.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCOCC5)cc4)c3c2)n[nH]c1N
413.505
1.94868
97.09
5
31
3
5
0.465872
6qr9
2.42
2,019
JEE
B
301
kd
=
190
nM
-6.721246
MOAD
Kd=190.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(Cc4ccc(C[NH+]5CCOCC5)cc4)c3c2)n[nH]c1N
413.505
1.94868
97.09
5
31
3
5
0.465872
6qra
1.71
2,019
JDK
A
301
kd
=
710
nM
-6.148742
MOAD
Kd=710.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCCC5)cc4)c3c2)n[nH]1
386.523
3.2307
64.07
5
29
3
3
0.493056
6qra
1.71
2,019
JDK
B
301
kd
=
710
nM
-6.148742
MOAD
Kd=710.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
Nc1cc(-c2ccc3ccn(Cc4ccc(C[NH+]5CCCCC5)cc4)c3c2)n[nH]1
386.523
3.2307
64.07
5
29
3
3
0.493056
6qrb
1.66
2,020
JEQ
A
301
kd
=
27
nM
-7.568636
MOAD
Kd=27.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(C[C@@H]4CCC[N@@H+](Cc5ccccc5)C4)c3c2)n[nH]c1N
411.533
2.98038
87.86
5
31
3
4
0.471756
6qrb
1.66
2,020
JEQ
B
301
kd
=
27
nM
-7.568636
MOAD
Kd=27.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
N#Cc1c(-c2ccc3ccn(C[C@H]4CCC[N@H+](Cc5ccccc5)C4)c3c2)n[nH]c1N
411.533
2.98038
87.86
5
31
3
4
0.471756
6qrc
1.73
2,019
JFE
A
301
kd
=
13
uM
-4.886057
MOAD
Kd=13.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(Cn2ccc3ccc(-c4cc(N)[nH]n4)cc32)c1
318.38
3.6705
68.86
4
24
2
4
0.603009
6qrc
1.73
2,019
JFE
B
302
kd
=
13
uM
-4.886057
MOAD
Kd=13.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(Cn2ccc3ccc(-c4cc(N)[nH]n4)cc32)c1
318.38
3.6705
68.86
4
24
2
4
0.603009
6qrd
1.75
2,019
JEH
A
303
kd
=
100
nM
-7
MOAD
Kd=100.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
CC(C)[NH+]1CCN(Cc2ccc(Cn3ccc4ccc(-c5n[nH]c(N)c5C#N)cc43)cc2)CC1
454.602
2.64248
91.1
6
34
3
5
0.417757
6qrd
1.75
2,019
JEH
B
302
kd
=
100
nM
-7
MOAD
Kd=100.0nM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
CC(C)[NH+]1CCN(Cc2ccc(Cn3ccc4ccc(-c5n[nH]c(N)c5C#N)cc43)cc2)CC1
454.602
2.64248
91.1
6
34
3
5
0.417757
6qre
1.93
2,019
JCQ
A
301
kd
=
14
uM
-4.853872
MOAD
Kd=14.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(COC(=O)c2cn[nH]c2)c1
232.239
1.7753
64.21
4
17
1
4
0.81586
6qre
1.93
2,019
JCQ
B
301
kd
=
14
uM
-4.853872
MOAD
Kd=14.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(COC(=O)c2cn[nH]c2)c1
232.239
1.7753
64.21
4
17
1
4
0.81586
6qre
1.93
2,019
JCQ
B
302
kd
=
14
uM
-4.853872
MOAD
Kd=14.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(COC(=O)c2cn[nH]c2)c1
232.239
1.7753
64.21
4
17
1
4
0.81586
6qre
1.93
2,019
JCQ
B
303
kd
=
14
uM
-4.853872
MOAD
Kd=14.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COc1cccc(COC(=O)c2cn[nH]c2)c1
232.239
1.7753
64.21
4
17
1
4
0.81586
6qrf
1.86
2,019
JF5
A
303
kd
=
33
uM
-4.481486
MOAD
Kd=33.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
O=C(OCc1ccccc1)c1cn[nH]c1
202.213
1.7667
54.98
3
15
1
3
0.771464
6qrf
1.86
2,019
JF5
A
301
kd
=
33
uM
-4.481486
MOAD
Kd=33.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
O=C(OCc1ccccc1)c1cn[nH]c1
202.213
1.7667
54.98
3
15
1
3
0.771464
6qrf
1.86
2,019
JF5
A
302
kd
=
33
uM
-4.481486
MOAD
Kd=33.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
O=C(OCc1ccccc1)c1cn[nH]c1
202.213
1.7667
54.98
3
15
1
3
0.771464
6qrf
1.86
2,019
JF5
B
301
kd
=
33
uM
-4.481486
MOAD
Kd=33.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
O=C(OCc1ccccc1)c1cn[nH]c1
202.213
1.7667
54.98
3
15
1
3
0.771464
6qrg
1.84
2,019
JET
A
301
kd
=
10
uM
-5
MOAD
Kd=10.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COC(=O)COc1cccc(COC(=O)c2cn[nH]c2)c1
290.275
1.3185
90.51
6
21
1
6
0.806793
6qrg
1.84
2,019
JET
B
302
kd
=
10
uM
-5
MOAD
Kd=10.0uM
B1MDI3,B1MDI3
tRNA (guanine-N(1)-)-methyltransferase,tRNA (guanine-N(1)-)-methyltransferase
COC(=O)COc1cccc(COC(=O)c2cn[nH]c2)c1
290.275
1.3185
90.51
6
21
1
6
0.806793
6qrl
1.84
2,020
C2E
A
401
kd
=
1.5
uM
-5.823909
MOAD
Kd=1.5uM
Q9ABT2
Hybrid kinase
Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[P@@](=O)([O-])O[C@H]4[C@@H](O)[C@H](n5cnc6c(=O)[nH]c(N)nc65)O[C@@H]4CO[P@@](=O)([O-])O[C@H]3[C@H]2O)c(=O)[nH]1
688.4
-4.3122
355.28
2
46
6
22
0.10841
6qrl
1.84
2,020
C2E
B
401
kd
=
1.5
uM
-5.823909
MOAD
Kd=1.5uM
Q9ABT2
Hybrid kinase
Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[P@@](=O)([O-])O[C@H]4[C@@H](O)[C@H](n5cnc6c(=O)[nH]c(N)nc65)O[C@@H]4CO[P@](=O)([O-])O[C@H]3[C@H]2O)c(=O)[nH]1
688.4
-4.3122
355.28
2
46
6
22
0.10841
6qs5
1.961
2,019
JGB
A
401
ic50
=
0.57
uM
-6.244125
MOAD
ic50=0.57uM
P28523
Casein kinase II subunit alpha
N#C/C(=C\c1ccc(O)c(O)c1)C(N)=O
204.185
0.49008
107.34
2
15
3
4
0.369813
6qtg
2.7
2,020
JH8
A
501
kd
=
0.77
nM
-9.113509
BindingDB
Kd=0.770000nM
P49336
Cyclin-dependent kinase 8
CN(C)C(=O)Cn1cc(-c2ccc(-c3cncc4ccccc34)cc2)cn1
356.429
3.8535
51.02
4
27
0
4
0.557956
6qtj
2.48
2,020
JHK
A
501
ic50
=
1.8
nM
-8.744727
MOAD
ic50=1.8nM
P49336
Cyclin-dependent kinase 8
CN(C)C(=O)Cn1cc(-c2ccc(-c3cncc4ccncc34)cc2)cn1
357.417
3.2485
63.91
4
27
0
5
0.562369
6qu7
1.52
2,019
JJE
A
403
ic50
=
4.17
nM
-8.379864
BindingDB
IC50=4.17nM
Q02127
Dihydroorotate dehydrogenase (quinone), mitochondrial
CCn1c(CO)nn(-c2cc(O[C@@H](C)C(F)(F)F)c(C(=O)Nc3c(F)cccc3Cl)cc2F)c1=O
520.842
4.0597
98.38
7
35
2
7
0.457908
6qut
1.96
2,020
J8N
A
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790
Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qut
1.96
2,020
J8N
B
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qut
1.96
2,020
J8N
C
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qut
1.96
2,020
J8N
C
303
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qut
1.96
2,020
J8N
D
302
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6qut
1.96
2,020
J8N
D
303
kd
=
2
nM
-8.69897
BindingDB
Kd=2.0nM
Q16790,Q16790
Carbonic anhydrase 9,Carbonic anhydrase 9
NS(=O)(=O)c1cc(C(=O)NCCCO)c(Sc2ccccc2)cc1Cl
400.909
2.2508
109.49
7
25
3
5
0.617302
6quv
1.475
2,019
JJN
B
201
kd
=
1
mM
-3
MOAD
Kd=1.0mM
P01116,P01116
GTPase KRas,GTPase KRas
C[N@H+]1CC[C@](C)([C@]23NC(=O)c4ccccc4[C@H]2c2ccccc2N3)CC1
348.47
1.9985
45.57
1
26
3
2
0.738133
6qva
2.05
2,019
9PI
A
605
ic50
~
1
uM
-6
MOAD
ic50~1.0uM
Q8KE09
CHAD domain
O=P([O-])([O-])O[P@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])O[P@](=O)([O-])O[P@@](=O)([O-])O[P@](=O)([O-])OP(=O)([O-])[O-]
726.738
-6.9446
481.13
16
37
0
28
0.133269