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39923634 | Bimetallic MOF nanoparticles decorated on polyacrylonitrile-based electrospun nanofiber membranes for synergistic antibacterial activity and organic dye adsorption. | Electrospun nanofiber membranes functionalized with metal-organic framework (MOF) are considered as a promising materials for removal contaminants from wastewater. In this study, a bottom-up approach was proposed for the preparation bimetallic MOF based polyacrylonitrile (PAN) electrospun nanofiber membranes. Polydopam... |
39923065 | Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma. | Radiotherapy (RT) is the primary treatment modality for nasopharyngeal carcinoma (NPC). However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy for NPC. Specifically, we have encapsulated met... |
39923064 | A new scheme for boosting in situ Fenton-like reaction in plant pathogenic tissues for selective structural degradation of capsid proteins. | Safe prevention and control of plant viruses is a global challenge. Inducing viral capsid protein (CP) degradation via hydroxyl radicals (∙OH) generated by an in situ Fenton-like reaction within plant pathogenic tissues is proposed for combating plant viruses in this study. We designed a new Fenton-like reaction induce... |
39922940 | Innovative approaches to asthma treatment: harnessing nanoparticle technology. | In the domain of respiratory illnesses, asthma remains a critical obstacle. The heterogeneous nature of this chronic inflammatory disease poses challenges during its treatment. Glucocorticoid-based combination drug therapy now dominates clinical treatments for asthma; however, glucocorticoid resistance, numerous advers... |
39922898 | Modification of Fe<sub>3</sub>O<sub>4</sub> magnetic nanoparticles for antibiotic detection. | The manufacture, modification, and application of surface-functionalized Fe<sub>3</sub>O<sub>4</sub> nanoparticles in the extraction and isolation of antibiotics are reviewed in this paper. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) can be used to characterize the morphological featur... |
39922812 | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration. | Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we re... |
39922810 | Self-driving lab for the photochemical synthesis of plasmonic nanoparticles with targeted structural and optical properties. | Many applications of plasmonic nanoparticles require precise control of their optical properties that are governed by nanoparticle dimensions, shape, morphology and composition. Finding reaction conditions for the synthesis of nanoparticles with targeted characteristics is a time-consuming and resource-intensive trial-... |
39921871 | A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy. | Nanoparticle-based mRNA delivery offers a versatile platform for innovative therapies. However, most of the current delivery systems are limited by poor serum tolerance, suboptimal endosomal escape and mRNA delivery efficacy. Herein, a highly efficient mRNA-delivering material is identified from a library of fluoropoly... |
39921870 | Controlled Self-Assembly and Photo-Thermal Activation of Viologen-Based 2D Semiconductors for Dual-Function Energy Management in All-Weather Applications. | Solar thermal technology offers a promising solution to water scarcity; however, the continuous operation of solar evaporators remains challenging due to sunlight's intermittent availability. Herein, an alternative strategy is proposed to achieve dual-functional energy management of photo-thermoactivated viologen T sem... |
39921706 | Novel Polymer Gel Lubricant Functionalized with a Phosphate Anion for Friction Reduction and Film Thickness Enhancement in Multiple Lubrication Conditions. | In this study, a supramolecular polymer gelator functionalized with a phosphate anion, PMUS-P, has been successfully synthesized through radical polymerization, and its physicochemical, rheological properties and tribological performance were carefully evaluated as a gel lubricant formed through non-covalent self-assem... |
39921645 | Rapid Quantification of Neuraminidase Activity by MALDI-TOF MS via On-Target Labeling of Its Substrate and Product. | Neuraminidase (NA) is a kind of glycoside hydrolase enzyme, functioning to remove terminal sialic acid (Sia) from glycans which are located on the cell surface. NA plays an essential role in cell interactions with ligands, microbes, and other cells during physiological and pathological processes. Additionally, NA is a ... |
39921641 | Copper-Based Two-Dimensional Conductive Metal-Organic Framework Thin Films for Ultrasensitive Detection of Perfluoroalkyls in Drinking Water. | Perfluoroalkyls (PFAS) continue to emerge as a global health threat making their effective detection and capture extremely important. Though metal-organic frameworks (MOFs) have stood out as a promising class of porous materials for sensing PFAS, detection limits remain insufficient and a fundamental understanding of d... |
39921617 | Spatial Confinement-Enhanced Electrochemiluminescence of Gold Nanoclusters on 3D Porous ZrO<sub>2</sub> Hollow Nanospheres for the Assessment of Acute Myocardial Infarction Protein Markers. | Herein, the gold nanoclusters@three-dimensional (3D) porous ZrO<sub>2</sub> hollow nanospheres (Au NCs@ZrO<sub>2</sub>) with spatial confinement-enhanced electrochemiluminescence (SCE-ECL) were first prepared to fabricate a biosensing platform for the ultrasensitive detection of insulin-like growth factor 1 (IGF-1), wh... |
39921482 | Sono-Piezo Dynamic Therapy: Utilizing Piezoelectric Materials as Sonosensitizer for Sonodynamic Therapy. | Sonodynamic therapy (SDT) represents a promising approach for cancer treatment. Compared to photodynamic therapy, SDT offers increased penetration depth and higher precision. However, the practical application of SDT is constrained by the low water solubility, poor tumor specificity, and metabolic susceptibility of mos... |
39920806 | Comparison of anesthetic effects of xylazine combined with alfaxalone or ketamine and maintained with isoflurane in captive Formosan Reeve's Muntjac (Muntiacus reevesi micrurus). | Formosan Reeve's muntjac is a Cervidae species endemic to Southeast China and Taiwan. However, research on different anesthetic protocols, their effects, and their safety in Formosan Reeve's muntjac is limited. This study evaluated the effects of ketamine-xylazine (KX) and alfaxalone-xylazine (AX) administered via blow... |
39920144 | Synthetic transmembrane DNA receptors enable engineered sensing and actuation. | In living organisms, cells synergistically couple cascade reaction pathways to achieve inter- and intracellular signal transduction by transmembrane protein receptors. The construction and assembly of synthetic receptor analogs that can mimic such biological processes is a central goal of synthetic biochemistry and bio... |
39920122 | Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity. | For successful transmission, the malaria parasite must traverse tissue epithelia and survive attack from the insect's innate immune system. Hemocytes play a multitude of roles in mosquitoes, including defense against invading pathogens. Here, we show that hemocytes of the major malaria vector Anopheles gambiae promote ... |
39866023 | Rhodamine-Gold Hybrid Nanosensor for Rapid and Selective Detection of Hg<sup>2+</sup> Ions in Environmental Samples. | This research focuses on the selective detection of Hg<sup>2+</sup> ions using hybrid nanosensors composed of rhodamine building blocks linked to polyamine units of varying chain lengths to produce Rho1-Rho4, which were subsequently conjugated with thioctic acid (RT1-RT4) and attached to the surface of gold nanoparticl... |
39832746 | Biomimetic calcium-chelation nanoparticles reprogram tumor metabolism to enhance antitumor immunity. | Metabolic reprogramming within the tumor microenvironment poses a significant obstacle to the therapeutic efficacy of antitumor immunity. Here, inspired by the diverse programme of cholesterol metabolism between tumor and immune cells, a biocompatible carboxy-modified cyclodextrin carrier equipped with a biomimetic sur... |
41836916 | The possibilities and challenges associated with selective targeting <i>Plasmodium falciparum</i> Hsp90 for Malaria. | The causative agent of malaria, <i>Plasmodium falciparum</i>, encodes four heat shock protein 90 isoforms in the cytosol, endoplasmic reticulum, mitochondria and apicoplast. PfHsp90s are considered potential targets for developing antimalarial drugs. However, the similarity between the druggable ATP binding pocket of t... |
40822122 | Supramolecular Organic Framework with Multidimensional Storage Spaces for Ultrahigh-Capacity Iodine Capture from Seawater. | Given the important role of iodine resources in chemical industry application and the scarcity of geogenic iodine resources, sustainable access to iodine resources has become increasingly crucial. Seawater is the largest iodine reservoir on Earth, but efficient chemical methods for recovering iodine from seawater are s... |
40124354 | Investigation of 2D Nb<sub>3</sub>C<sub>2</sub>-Based MXenes as the Anode Material for LIBs: A Theoretical Study. | MXenes, two-dimensional transition metal carbides/nitrides, have gained substantial interest owing to their distinctive properties. This study utilizes density functional theory (DFT) calculations to study the electronic, magnetic, and thermoelectric properties of pristine, molybdenum (Mo), and Te-doped Nb<sub>3</sub>C... |
40070456 | Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction <i>via</i> reversible covalent imine tethering. | Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular networ... |
40047670 | From Present Innovations to Future Potential: The Promising Journey of Lithium-Ion Batteries. | Lithium-ion batteries (LIBs) have become integral to modern technology, powering portable electronics, electric vehicles, and renewable energy storage systems. This document explores the complexities and advancements in LIB technology, highlighting the fundamental components such as anodes, cathodes, electrolytes, and ... |
40034308 | Frontal affinity chromatography to investigate the interaction of benzophenone with humic acid supported on microbore monolithic columns. | The principles of frontal affinity chromatography were used to determine the sorption constants and sorption capacities of benzophenone on immobilized humic acid. Poly(glycidyl-co-ethylene dimethacrylate) monoliths were constructed inside microbore capillaries (12 cm long × 1.016 mm internal diameter) and further amina... |
40026574 | The endocytic pathway for absorption of exogenous RNAs in <i>Verticillium dahliae</i>. | RNAi technologies have been exploited to control viruses, pests, oomycetes, and fungal phytopathogens that cause disasters in host plants, including many agronomically significant crops. Double-stranded RNA (dsRNA) or small interfering RNA (siRNA) has been applied as a trigger for trans-kingdom RNAi between hosts and f... |
40007963 | <i>Eucalyptus grandis</i> WRKY genes provide insight into the role of arbuscular mycorrhizal symbiosis in defense against <i>Ralstonia solanacearum</i>. | <h4>Introduction</h4>WRKY transcription factors are essential for plant growth, health, and responses to biotic and abiotic stress.<h4>Methods</h4>In this study, we performed a deep <i>in silico</i> characterization of the WRKY gene family in the genome of <i>Eucalyptus grandis</i>. We also analyzed the expression prof... |
40006772 | <i>Agave macroacantha</i> Transcriptome Reveals Candidate <i>CNGC</i> Genes Responsive to Cold Stress in Agave. | Agave, with its unique appearance and ability to produce hard fibers, holds high economic value. However, low temperatures during winter can restrict its growth and even damage the leaves, causing a loss of ornamental appeal or affecting the fiber quality. Conversely, the plant <i>cyclic nucleotide-gated channel</i> (<... |
40006583 | Cancer Vaccines and Beyond: The Transformative Role of Nanotechnology in Immunotherapy. | Cancer is one of the leading causes of morbidity and mortality globally, responsible for approximately 10 million deaths in 2022 and an estimated 21 million new cases in 2024. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy often present limitations in efficacy and side effects. Howev... |
40006582 | Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems. | Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability and difficulties in ensuring patient adherence. These challenges have driven the development of advanced drug delivery systems (DDS), with hydrogel... |
40006101 | Heuristic Guidelines for Developing Polymer/Ionic Liquid Blend Membranes. | In the search of increasingly effective materials for enhancing gas transport in membranes, the incorporation of ionic liquids within a polymeric matrix is attracting a lot of interest in the development of advanced membranes to be applied to CO<sub>2</sub> separation. An analysis of the open literature focusing on pol... |
40006099 | Synthesis of a Free-Standing Ternary WO<sub>3</sub>/CNT/ZnO-Chitosan Composite Photocatalytic Membrane for the Mitigation of Protein Fouling in Membranes. | The application of membrane filtration, particularly micro- and ultra-filtration, in food and pharmaceutical industries often faces the issue of protein fouling. In this study, we aimed to fabricate a free-standing ternary tungsten trioxide/carbon nanotube/zinc oxide (WO<sub>3</sub>/CNT/ZnO)-chitosan composite photocat... |
40006097 | Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review. | Drug delivery systems have revolutionized traditional drug administration methods by addressing various challenges, such as enhancing drug solubility, prolonging effectiveness, minimizing adverse effects, and preserving potency. Nanotechnology-based drug delivery systems, particularly nanoparticles (NPs) and nanofibers... |
40005731 | The Role of the Hfq Protein in Bacterial Resistance to Antibiotics: A Narrative Review. | The antibiotic resistance of pathogenic microorganisms is currently one of most major medical problems, causing a few million deaths every year worldwide due to untreatable bacterial infections. Unfortunately, the prognosis is even worse, as over 8 million deaths associated with antibiotic resistance are expected to oc... |
40005090 | Designed Reactive Natural Deep Eutectic Solvents for Lipase-Catalyzed Esterification. | Natural deep eutectic solvents (NADESs) are a sustainable, green option for extraction and reaction media in biorefineries and various chemical and biotechnological applications. Particularly, enzymatic reactions profit from NADES applications, as these solvents help to maintain high substrate solubility while improvin... |
40005089 | Reduction of 4-Nitrophenol to 4-Aminophenol by Reusable CuFe<sub>5</sub>O<sub>8</sub>-Based Catalysts Synthesized by Co-Precipitation Method. | The reduction of unfriendly 4-nitrophenol to make it unimpactful with the environment (4-aminophenol) was carried out using the metastable form of copper ferrite (CuFe<sub>5</sub>O<sub>8</sub>) synthesized by the co-precipitation of metal nitrate salts, an efficient method with inexpensive and abundant starting materia... |
40003880 | Retinal Protective Effect of Mono-Ethyl Fumarate in Experimental Age-Related Macular Degeneration via Anti-Oxidative and Anti-Apoptotic Alterations. | Age-related macular degeneration (AMD) is a leading cause of vision impairment in people over the age of 60. Currently, the FDA-approved drugs for AMD have various side effects, and there is a notable lack of drug development for dry AMD. This study aimed to explore the therapeutic effects of mono-ethyl fumarate (MEF) ... |
40003873 | Transcriptome Profiling of <i>Euproctis pseudoconspersa</i> Reveals Candidate Olfactory Genes for Type III Sex Pheromone Detection. | The tea tussock moth (<i>Euproctis pseudoconspersa</i>) is a common tea plantation pest with Type III sex pheromone components (SPCs). However, the olfactory genes involved in the perception of Type III SPCs remain unknown. To identify the olfactory genes involved in <i>E</i>. <i>pseudoconspersa</i> olfactory perceptio... |
40003872 | Lactoferrin: Properties and Potential Uses in the Food Industry. | Lactoferrin (LF) is an 80 kDa glycoprotein that contains approximately 700 amino acids and is a member of the transferrin family. The essential properties of LF, including antimicrobial, antiviral, anticancer, anti-inflammatory, antioxidant, and probiotic effects, have been studied for decades. The iron chelation activ... |
40002954 | Current Review of Monoclonal Antibody Therapeutics in Small Animal Medicine. | Monoclonal antibody therapy has been a cornerstone of human healthcare for nearly four decades, effectively treating a wide range of diseases including cancers, autoimmune disorders, and inflammatory conditions. However, its application in veterinary medicine is a relatively recent development, offering a promising the... |
40001543 | Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects. | Cancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options. Ubiquitin-specific proteases (USPs) have emerged as promising therapeutic targets in cancer treatment due to their crucial roles in ... |
40001541 | Determining Ligand Binding and Specificity Within the β<sub>2</sub>-Integrin Family with a Novel Assay Platform. | The family of the β<sub>2</sub>-integrin receptors is critically involved in host defense and homeostasis, by mediating immune cell adhesion, migration, and phagocytosis. Due to their key roles in immune surveillance and inflammation, their modulation has been recognized as an attractive drug target. However, the devel... |
40001410 | FDA-Approved Antibacterials and Echinocandins. | Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA). Peptides present a promising opportunity to address serious infections that may be challenging to manage through other means. Peptides exhibit the capability to l... |
39997818 | Amyloid Fibrils and Their Applications: Current Status and Latest Developments. | Amyloid fibrils are one of the important forms of protein aggregates, first discovered in the pathological brain tissues of patients with various neurodegenerative diseases. They are considered the core pathological markers of different neurodegenerative diseases. In recent years, research has found that multiple prote... |
39997817 | Advanced Low-Dimensional Carbon Nanomaterials for Oxygen Electrocatalysis. | Amid rising global energy demand and worsening environmental pollution, there is an urgent need for efficient energy storage and conversion technologies. Oxygen electrocatalytic reactions, specifically the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER) are critical processes in these technologi... |
39997815 | Advancements in Green Synthesis of Silver-Based Nanoparticles: Antimicrobial and Antifungal Properties in Various Films. | Nanotechnology is an evolving field that presents extensive opportunities in antimicrobial and eco-friendly food packaging applications. Silver nanoparticles (AgNPs) are particularly valuable in this context due to their outstanding physicochemical properties and demonstrated biological and antimicrobial efficacy, rend... |
39997193 | Advanced Technologies for Large Scale Supply of Marine Drugs. | Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structur... |
39997196 | Marine-Derived Diterpenes from 2019 to 2024: Structures, Biological Activities, Synthesis and Potential Applications. | Marine diterpenes are an important category of secondary metabolites derived from marine sources, found in a variety of marine animals, plants, and fungi. The increasing diversity of diterpene compounds, along with their unique chemical structures and specific biological activities, have attracted widespread attention.... |
39996665 | From Single-Chain Polymeric Nanoparticles to Interpenetrating Polymer Network Organogels: A One-Pot Fabrication Approach. | In this study, we developed a novel one-pot synthesis method to fabricate well-defined single-chain polymeric nanoparticles (SCNPs) integrated with interpenetrating polymer network (IPN) systems. The synthesis process involved an initial intramolecular crosslinking of poly(methyl methacrylate-<i>co</i>-glycidyl methacr... |
39996666 | Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings. | Recent advancements in wound dressing materials have significantly improved acute and chronic wound management by addressing challenges such as infection control, moisture balance, and enhanced healing. Important progress has been made, especially with hydrogels, foams, and antimicrobial materials for creating optimize... |
39995209 | Visualizing Intracellular Sialylation with Click Chemistry and Expansion Microscopy. | Metabolic labeling techniques allow the incorporation of bioorthogonal reporters into glycans, enabling the targeted bioconjugation of molecular dyes within cells through click and bioorthogonal chemistry. Metabolic oligosaccharide engineering (MOE) has attracted considerable interest due to the essential role of glyco... |
39986796 | A strategy to reduce the bitterness of green tea extract: Preparation of cyclodextrin inclusion and assessment of its antioxidant activity and stability. | Green tea extract (GTE) is rich in polyphenols that are the main body of functional activity, but the natural bitterness greatly restricts its applications in food areas. In this study, the effect of β-cyclodextrin (β-CD) on the bitterness and properties of GTE were investigated. The bitterness intensity was evaluated ... |
39986782 | Encapsulation of oleanolic acid into cyclodextrin metal-organic frameworks by co-crystallization: Preparation, structure characterization and its effect on a zebrafish larva NAFLD model. | Oleanolic acid (OA) is a common pentacyclic triterpenoid and has been used to relieve metabolic-related diseases. However, its low water solubility severely limits its clinical application. In this study, OA was encapsulated by a cyclodextrin metal-organic framework material (CD-MOF) using the co-crystallization method... |
39983396 | High-temperature RGB ultralong afterglow carbon dots based on cavity encapsulated by cyclodextrins for anti-counterfeiting and information encryption. | Room temperature phosphorescent (RTP) carbon dots (CDs) have the disadvantages of short lifetime, single wavelength and poor stability. Phosphorescence usually suffers severe thermal decay due to strong non-radiative transitions caused by temperature increasing, limiting the use of CDs. Herein, α-Cyclodextrin provides ... |
39938268 | One pot preparation of magnetic benzylated cyclodextrin-based hyper-cross-linked polymer for phthalate esters extraction from tea beverages. | The increasing popularity of packaged beverages has raised concerns about the health risks associated with phthalate esters (PAEs), which are commonly found in plastics used for packaging. This study presents an eco-friendly approach for synthesizing a magnetic benzylated cyclodextrin-based hyper-cross-linked polymer (... |
39936703 | Investigation of the activity of 4-aminoquinolines as cysteine protease inhibitors with application in the treatment of Chagas disease. | <h4>Background</h4>Chagas disease (CD) is a neglected tropical disease caused by Trypanosoma cruzi. The current drugs used to treat these diseases have limited efficacy and produce severe side effects. 4-aminoquinoline derivatives were shown to be a promising class of inhibitors of cysteine proteases cruzain and TbrCAT... |
39936025 | Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format. | <h4>Purpose</h4>For the diagnosis of various diseases, simultaneous sensitive detection of multiple biomarkers using low sample volumes is needed. The purpose of the present research was to develop sensitive multiplex detection model of QD-based ELISA (QLISA), through the spectroscopic QD-analyte complex measurements i... |
39933329 | MOF-derived nitrogen, sulfur, cobalt, and copper co-doped graphite felt for high-efficiency vanadium redox flow battery electrodes. | The low electrocatalytic activity of pristine graphite felt (GF) electrodes towards V(II)/V(III) and V(IV)/V(V) redox couples poses a significant challenge in vanadium redox flow batteries (VRFBs). Here, Metal-organic frameworks (MOFs) containing Cu, Co, N, and S are proposed as precursors for the construction of metal... |
39931072 | Berberine-induced browning and energy metabolism: mechanisms and implications. | Obesity has become a global pandemic. The approaches researched to prevent it include decreasing energy intake and/or enhancing energy expenditure. Therefore, research on brown adipose tissue is of great importance. Brown adipose tissue is characterized by its high mitochondrial content. Mitochondrial uncoupling protei... |
39927832 | Advances in nanobody multimerization and multispecificity: from in vivo assembly to in vitro production. | NANOBODIES® (Nbs) have emerged as valuable tools across therapeutic, diagnostic, and industrial applications owing to their small size and consequent ability to bind unique epitopes inaccessible to conventional antibodies. While Nbs retrieved from immune libraries normally possess sufficient affinity and specificity fo... |
39926231 | Ferromagnetically coupled tetranuclear Ni(ii)-2-oxy-aceto- or benzo-phenonate complexes. | Reaction of 2-hydroxy-acetophenone (HL) or 2-hydroxy-benzophenone (HL') with nickel(ii) acetate provides the tetrakis-[(μ<sub>3</sub>-methanolato-κ<sup>3</sup> <i>O</i>:<i>O</i>:<i>O</i>)(methanol-κ<i>O</i>)(2-oxyacetophenone-κ<sup>2</sup> <i>O</i>,<i>O</i>')nickel(ii)], [Ni(L)(μ<sub>3</sub>-CH<sub>3</sub>O)(CH<sub>3</... |
39926227 | Nanoscale drug formulations for the treatment of Alzheimer's disease progression. | Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments. The blood-brain barrier hinders drug delivery to the brain, limiting therapeutic efficacy. Nanoparticle-based systems have emerged as promising tools to overcome these challenges. This review highlights ... |
39926108 | Exploring the therapeutic potential of oleanolic acid and its derivatives in cancer treatment: a comprehensive review. | Oleanolic acid (OA) is a triterpenoid that occurs naturally and may be isolated from various plants. Analogs of oleanolic acid can be produced artificially or naturally. The current treatments have limited selectivity and may also impact normal cells. OA and its derivatives provide a promising cancer treatment platform... |
39926106 | Biocontrol efficacy of native <i>Metarhizium rileyi</i> (Hypocreales: Clavicipitaceae) isolates against <i>Spodoptera litura</i> (F) (Lepidoptera: Noctuidae) and in silico effect of the secondary metabolites against the virulent proteins of the insect. | This study explores the insecticidal potential of secondary metabolites derived from <i>Metarhizium rileyi</i> against <i>Spodoptera litura</i> through an integrative approach involving genomics, metabolomics, and bioinformatics. Four native isolates of <i>M. rileyi</i> were identified and characterized for their insec... |
39925787 | <i>In Silico</i> Analysis and Characterization of the Immunogenicity of <i>Toxoplasma gondii</i> Rhoptry Protein 18. | Rhoptry protein 18 (ROP18) is a key virulence factor secreted into host cells during the invasion of <i>Toxoplasma gondii</i> (<i>T. gondii</i>) and plays an important role in the pathogenesis of infection. Due to its potential as a vaccine candidate, this study aimed to characterize several properties of the <i>T. gon... |
39924041 | Cage-like ferritin and lysozyme heteroprotein complexes coacervation for encapsulation, stabilization, and sustained release of bioactive compounds. | The ferritin (FRT) with a modifiable cavity can interact with the lysozyme (LYS) to form a heteroprotein complex coacervation (HPCC). This interaction is believed to combine the unique properties of FRT and LYS to form a novel structure with enhanced characteristics. The study aimed to explore the pH-dependent complexa... |
39924028 | Development of novel sodium alginate-based light-responsive controlled-release active packaging film. | Developing intelligent active packaging films with responsive controlled-release properties for food preservation is highly desirable. Herein, a light-responsive carrier material PBA-IRMOF-3 was prepared by modifying azobenzene 4-carboxylic acid (PBA) with azobenzene photosensitive group on isoreticular metal-organic f... |
39923924 | The essential role of sphingolipids in TRPC5 ion channel localization and functionality within lipid rafts. | Sphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels. These lipids regulate membrane fluidity and protein-lipid interactions, directly influencing ion channel activity, trafficking, and s... |
39923847 | Citrulline Inhibits Clostridioides difficile Infection With Anti-inflammatory Effects. | <h4>Background & aims</h4>Clostridioides difficile infection (CDI) causes colitis and diarrhea. C. difficile bacterium produces toxins A and B, which cause intestinal inflammation. A metabolomics analysis discovered fecal metabolites with anti-inflammatory effects in CDI. We aimed to identify an anti-CDI metabolite tha... |
39922252 | A novel hierarchical porous ZIF-8 for effective removal of three non-steroidal anti-inflammatory drugs simultaneously from environment. | Metal organic frameworks (MOFs) adsorbents have significant advantages to remove contaminates. While their microporous structure is not conducive to entry of larger molecules, making it difficult to simultaneously utilize the inner and outer surfaces of the pores to achieve higher adsorption capacity. In this work, the... |
39922199 | Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases. | This study addresses the urgent need for effective therapies for patients with brain metastases from cutaneous melanoma, a major cause of treatment failure despite recent therapeutic advances. Utilizing mouse models that mimic human melanoma brain metastases, this study investigates the necessity of focal adhesion kina... |
39922192 | Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses. | DPP4 was considered a canonical receptor for merbecoviruses until the recent discovery of African bat-borne MERS-related coronaviruses using ACE2. The extent and diversity of ACE2 utilization among merbecoviruses and their receptor species tropism remain unknown. Here, we reveal that HKU5 enters host cells utilizing Pi... |
39922191 | Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses. | The angiotensin-converting enzyme 2 (ACE2) receptor is shared by various coronaviruses with distinct receptor-binding domain (RBD) architectures, yet our understanding of these convergent acquisition events remains elusive. Here, we report that two bat MERS-related coronaviruses (MERSr-CoVs) infecting Pipistrellus nath... |
39922049 | Currents status of radiotracers for breast cancer imaging in PET. | Radiolabeled molecules have become valuable tools in the diagnosis, monitoring, and treatment of cancer, particularly breast cancer. Through the use of radiotracers, clinicians can target specific tumor cells, assess microenvironments, and identify metastases. These radiopharmaceuticals, based on radionuclides, enable ... |
39921319 | Aspergillus Mycotoxins: The Major Food Contaminants. | Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose a severe threat to human health. Aspergillus, a genus of fungi, is capable of producing mycotoxins, with aflatoxins (AFs) and ochratoxins being its principal types. Aspergillus mycotoxins can contaminate a wide range o... |
39921305 | Dynamic Assembly of Microgels and Polymers at Non-Aqueous Liquid/Liquid Interfaces. | Particle assembly at liquid-liquid interfaces presents a promising bottom-up strategy for creating supramolecular materials with advanced functionalities. However, the significantly lower interfacial tension observed in immiscible organic phases compared to traditional oil-water systems has hindered the effective adsor... |
39921286 | Exploring New Bioorthogonal Catalysts: Scaffold Diversity in Catalysis for Chemical Biology. | Bioorthogonal catalysis has revolutionized the field of chemical biology by enabling selective and controlled chemical transformations within living systems. Research has converged on the development of innovative catalyst scaffolds, seeking to broaden the scope of bioorthogonal reactions, boost their efficiency, and s... |
39921285 | Layered Anion-Mixed Oxycompounds: Synthesis, Properties, and Applications. | Layered anion-mixed oxycompounds have emerged as pivotal materials across diverse technological domains encompassing electronics, optics, sensing, catalysis, and energy applications. Capitalizing on the unique properties imparted by the additional anion, these compounds exhibit exceptional characteristics including ult... |
39920826 | Mitochondrial transplantation for cardioprotection and induction of angiogenesis in ischemic heart disease. | To date, the regenerative potential of mitochondrial transplantation (MT) has been extensively investigated under several pathologies. Among various cardiovascular diseases, ischemic heart disease (IHD), the most prevalent pathological condition in human medicine, is induced by coronary artery narrowing, or occlusion, ... |
39920825 | Molecular imprinted polymer-based potentiometric approach for the determination of carvedilol and ivabradine hydrochloride in dosage form, spiked human plasma and in presence of their oxidative degradates. | Carivalan<sup>®</sup> pharmaceutical formulation, which includes carvedilol and ivabradine hydrochloride, is commonly prescribed for alleviating pain associated with angina. Solid contact ion-selective electrodes with wide range of applications have been developed for analysis of these two active ingredients. Those typ... |
39920818 | Nanozyme-based aptasensors for the detection of tumor biomarkers. | A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules. Nanozymes are nanomaterials that possess enzyme-like properties, demonstrating substantial potential for enhancing the sensing capabilities of biosensors. In recent years, ... |
39920791 | Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gut microbiota. | Despite the approval of several artificial nanotherapeutics for the treatment of triple-negative breast cancer (TNBC), significant challenges, including unsatisfactory therapeutic outcomes, severe side effects, and the high cost of large-scale production, still restrict their long-term application. In contrast, plant-d... |
39920771 | Targeting ferroptosis in prostate cancer management: molecular mechanisms, multidisciplinary strategies and translational perspectives. | Prostate cancer (PCa) is a kind of malignant solid tumor commonly observed among males worldwide. The dilemma of increasing incidence with therapeutic resistance has become the leading issue in PCa clinical management. Ferroptosis is a new form of regulatory cell death caused by iron-dependent lipid peroxidation, which... |
39920742 | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration. | Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase in the aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based cartilage tissue engineering has emerged as a promising therapeutic option for treating... |
39920740 | Advances in growth factor-containing 3D printed scaffolds in orthopedics. | Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems in orthopedics can be solved through bone tissue engineering, which can be used to treat fractures, bone defects, arthritis, etc. More importantly, it can provide an alternative to traditional bone grafti... |
39920702 | Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum. | <h4>Background</h4>RNA pesticide is regarded as the "third revolution in the history of pesticides". However, the double-stranded RNA (dsRNA) is easily degraded in the environment, and its delivery efficiency is not sufficient for pest management. This study aimed to construct a star polycation (SPc)-based delivery pla... |
39920688 | A systematic review of nanocarriers used in medicine and beyond - definition and categorization framework. | Nanocarriers are transport and encapsulation systems that primarily serve to protect and improve the dispersibility of predominantly hydrophobic active ingredients but also enable their targeted delivery and controlled release at the site of action. Nanocarriers are mainly made of either organic or inorganic materials,... |
39920579 | Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia. | Lactation is a crucial phase of brain development, and the events and nutrients during this period have long-term consequences for the occurrence of depression. This study investigated the effect and mechanism of lactoferrin (LF) deficiency during lactation on depression in adulthood. Lactation LF-deficient mice were e... |
39920567 | Bioavailability of Tea Polyphenols: A Key Factor in Understanding Their Mechanisms of Action In Vivo and Health Effects. | Tea polyphenols (TPP) are key contributors to the beneficial health effects of green tea and black tea. However, their molecular mechanisms of action remain unclear. This article discusses the importance of the bioavailability of TPP in understanding their mechanisms of action and health effects of tea consumption. The... |
39920486 | Prediction of imminent osteoporotic fracture risk in Danish postmenopausal women-can the addition of self-reported clinical risk factors improve the prediction of the register-based FREM algorithm? | Obtaining accurate self-reports on clinical risk factors, such as parental hip fracture or alcohol and tobacco use, limits the utility of conventional risk scores for fracture risk. We demonstrate that fracture-risk prediction based on administrative health data alone performs equally to prediction based on self-report... |
39920481 | Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases. | Autophagy related genes (ATGs) play essential roles in maintaining cellular functions, although biological and pathological alterations of ATG phenotypes remain poorly understood. To address this knowledge gap, we utilized the single-cell sequencing technology to elucidate the transcriptomic atlas of ATGs in lung disea... |
39920231 | Expanding the molecular grammar of polar residues and arginine in FUS phase separation. | A molecular grammar governing low-complexity prion-like domain phase separation (PS) has identified tyrosine and arginine as primary drivers via aromatic-aromatic and aromatic-arginine interactions. Here we show that additional residues and contacts contribute to PS, highlighting the need to include these contributions... |
39920133 | Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets. | Pancreatic islets are densely packed cellular aggregates containing various hormonal cell types essential for blood glucose regulation. Interactions among these cells markedly affect the glucoregulatory functions of islets along with the surrounding niche and pancreatic tissue-specific geometrical organization. However... |
39920129 | Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing. | Uncontrolled haemorrhage is a leading cause of trauma-related fatalities, highlighting the critical need for rapid and effective haemostasis. Current haemostatic materials encounter limitations such as slow clotting and weak mechanical strength, while most of bioadhesives compromise their adhesion performance to wet ti... |
39920120 | Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease. | Adenine base editing can convert sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a naturally occurring variant that is clinically asymptomatic. However, the quality and functionality of purified HbG and of mature HbGG and HbGS red blood cells (RBC) has not been assessed. Here, we develop a mouse mod... |
39920107 | P-block element modulated 1 T phase MoS<sub>2</sub> with Ru lattice grafting for high-performance Li | |O<sub>2</sub> batteries. | The metallic phase MoS<sub>2</sub> (1T-MoS<sub>2</sub>) supported metal-nanocatalyst is an appealing material system for accelerating the redox kinetics of non-aqueous Li | |O<sub>2</sub> batteries. However, the drawbacks associated with the surface orbital steric effect and the internal electron coupling results in a ... |
39920086 | Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence. | With the growing number and diversity of known genome sequences, there is an increasing opportunity to regulate gene expression through synthetic, cell-permeable small molecules. Enhancing the DNA sequence recognition abilities of minor groove compounds has the potential to broaden their therapeutic applications with s... |
39920081 | UiO-66 MOFs-Based "Epi-Nano-Sonosensitizer" for Ultrasound-Driven Cascade Immunotherapy against B-Cell Lymphoma. | B-cell lymphoma (BCL) is a hematological malignancy with high heterogeneity and represents an aggressive proliferation of mature B-cells. Despite the initial success of traditional treatments for BCL in clinical trials, a majority of patients eventually develop resistance to therapy and have poor clinical outcomes. Epi... |
39919822 | Nano-targeted delivery system: a promising strategy of anthocyanin encapsulation for treating intestinal inflammation. | Anthocyanins are natural flavonoids derived from plants, widely recognized for their health-promoting effects, specifically to treat inflammatory bowel disease (Crohn's disease and ulcerative colitis). However, certain limitations are associated with their use, including instability, low solubility and permeability, po... |
39919730 | Enhancing CO<sub>2</sub> Capture Via Fast Microwave-Assisted Synthesis of the CALF-20 Metal-Organic Framework. | Metal-organic frameworks (MOFs) are promising porous materials for CO<sub>2</sub> adsorption due to their high surface area, tunable properties, and selective adsorption capabilities. The recently reported Calgary Framework 20 (CALF-20) MOF has very appealing CO<sub>2</sub> capture properties: high uptake capacity; low... |
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