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39919319 | Architecting Metal-Organic Frameworks at Molecular Level toward Direct Air Capture. | Escalating carbon dioxide (CO<sub>2</sub>) emissions have intensified the greenhouse effect, posing a significant long-term threat to environmental sustainability. Direct air capture (DAC) has emerged as a promising approach to achieving a net-zero carbon future, which offers several practical advantages, such as indep... |
39919302 | Multiple Levels of Organization in Amphiphilic Diblock Copolymers Based on Poly(γ-benzyl-l-glutamate) Produced by Aqueous ROPISA. | A recent method for producing amphiphilic block copolymers and nano-objects based on the ring-opening polymerization-induced self-assembly (ROPISA) in aqueous buffer is explored with respect to the tunability toward nanostructures. ROPISA gives rise to polypeptide copolymers with unprecedented levels of organization. B... |
39919175 | Biodegradable origami enables closed-loop sustainable robotic systems. | Robots are increasingly integral across various sectors due to their efficiency and superior capabilities, which enable performance beyond human potential. However, the development of robotic systems often conflicts with the sustainable development goals set by the United Nations, as they generate considerable nondegra... |
39919172 | Asgard archaea reveal the conserved principles of ESCRT-III membrane remodeling. | ESCRT-III proteins assemble into composite polymers that undergo stepwise changes in composition and structure to deform membranes across the tree of life. Here, using a phylogenetic analysis, we demonstrate that the two endosomal sorting complex required for transport III (ESCRT-III) proteins present in eukaryote's cl... |
39919117 | Alternative lipid synthesis in response to phosphate limitation promotes antibiotic tolerance in Gram-negative ESKAPE pathogens. | The Gram-negative outer membrane protects bacterial cells from environmental toxins such as antibiotics. The outer membrane lipid bilayer is asymmetric; while glycerophospholipids compose the periplasmic facing leaflet, the surface layer is enriched with phosphate-containing lipopolysaccharides. The anionic phosphates ... |
39919064 | Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. | Helicobacter pylori is a gram-negative bacterium that persistently infects the human stomach, leading to peptic ulcers, gastritis, and an increased risk of gastric cancer. The extremophilic characteristics of this bacterium make it resistant to current drug treatments, and there are no licensed vaccines available again... |
39918873 | Molecular dissection of the role of ACE2 in glucose homeostasis. | Angiotensin-converting enzyme 2 (ACE2) was discovered 25 years ago as a negative regulator of the renin-angiotensin system, opposing the effects of angiotensin II. Beyond its well-demonstrated roles in cardiovascular regulation and COVID-19 pathology, ACE2 is involved in a plethora of physiopathological processes. In t... |
39918744 | Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights. | Atopic dermatitis (AD) is a paradigmatic prevalent, long-lasting, and inflammatory skin condition with a diverse range of clinical manifestations. The etiology and clinical symptoms of AD are influenced by complex pathophysiological processes, which involve a strong genetic component, epidermal dysfunction, and immunol... |
39918592 | The optimal timing for definitive operative stabilization of pelvic fractures in polytrauma patients: effects on clinical outcomes - a systematic review. | <h4>Purpose</h4>The optimal timing for definitive surgical treatment of pelvic fractures in polytrauma patients remains a topic of ongoing discussion due to the complexity of these injuries. This analysis therefore aims to systematically compare early versus late definitive operative stabilization of pelvic fractures o... |
39918545 | Light-Induced Increase in Bond Strength─from Chalcogen Bond to Three-Electron σ Bond upon Excitation. | Chalcogen bonds are σ hole interactions between a chalcogen center and a Lewis base center and have been applied in recent years as an alternative to hydrogen bonds in supramolecular chemistry and catalysis. While the electronic interactions of chalcogen bonds in the ground state have been intensively analyzed, there i... |
39918443 | Spatially Controlled Self-Assembly of Supramolecular Hydrogels Enabled by Light-Triggered Catalysis. | Spatial control over supramolecular self-assembly prevails in living system, yet remains difficult to replicate in synthetic scenarios. Here, on the basis of a hydrazone formation-mediated supramolecular hydrogelation system, access to patterning of supramolecular hydrogels is demonstrated via a light-triggered catalys... |
39918352 | Supramolecular Diodes with Donor-Acceptor Interactions. | Inspired by the initial proposal of σ-bridged donor-acceptor (D-σ-A) single-molecule diodes in 1974, extensive studies over the past 50 years have explored various designs for π-conjugated D-π-A single-molecule diodes due to their feasible chemical synthesis and effective charge transfer. However, the rectification rat... |
39918272 | One-Pot Hetero-Di-C-Glycosylation of the Natural Polyphenol Phloretin by a Single C-Glycosyltransferase With Broad Sugar Substrate Specificity. | The structural motif of hetero-di-C-glycosyl compound is prominent in plant polyphenol natural products and involves two different glycosyl residues (e.g., β-d-glucosyl, β-d-xylosyl) attached to carbons of the same phenolic ring. Polyphenol hetero-di-C-glycosides attract attention as specialized ingredients of herbal m... |
39918074 | Beyond species and spatial boundaries: Enabling long-distance gene silencing in plants via guanidinium-siRNA nanoparticles. | RNA interference (RNAi) has been widely used in agriculture. However, it is well accepted that common methods of plant RNAi are species-dependent and lack systematic efficiency. This study designed a thiolated siRNA nanoparticle, guanidinium (Gu<sup>+</sup>)-containing disulfide assembled siRNA (Gu<sup>+</sup>-siRNA), ... |
39916592 | Ligand-Mediated Highly Ordered Aggregation of 5-Mercapto-2-Nitrobenzoic Acid Protected Atomically Precise Silver Nanocluster. | Understanding self-assembly of atomically precise nanoclusters is of paramount interest in designing various aggregated super-structures. Here pH-mediated self-assembly is reported of atomically precise Ag<sub>44</sub>(MNBA)<sub>30</sub> (MNBA = 5-mercapto-2-nitrobenzoic acid) nanoclusters in aqueous solution. These na... |
39916555 | Tailoring the Composite Polymer Electrolytes with Metal-Organic Framework for High-Performance Li-O<sub>2</sub> Batteries. | Lithium-oxygen (Li-O<sub>2</sub>) batteries with high energy density have given rise to tremendous advances in developing highly efficient energy storage devices. However, the barrier of Li dendrite growth and the liquid electrolyte volatilization under semi-open architectures still restrict their future applications. ... |
39916550 | Discovery of New Nanomolar Selective IRAP Inhibitors. | Among the M1 family of oxytocinase aminopeptidases, insulin-regulated aminopeptidase IRAP, is an emerging drug target implicated in various biological pathways and particularly in MHC-I antigen presentation through amino-terminal trimming of exogenous cross-presented peptides. A few series of inhibitors inspired either... |
39916512 | Nano-Scale Anti-Cancer Drug Delivery by a Zn-Based Metal Organic Framework Carrier. | Porous functional metal organic frameworks (MOFs) have showcased their potential in biomedical applications, specifically in drug delivery systems (DDSs), due to high surface area, tailorable pore size, tunable functionality, etc. In this work, the efficient nano drug carrier behavior of a Zn-MOF is reported for two hi... |
39915884 | Dysbiosis and extraintestinal cancers. | The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances in the remarkable correlation between dysbiosis and extraintestinal cancers, the underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their m... |
39915447 | Hepatocellular carcinoma: signaling pathways and therapeutic advances. | Liver cancer represents a major global health concern, with projections indicating that the number of new cases could surpass 1 million annually by 2025. Hepatocellular carcinoma (HCC) constitutes around 90% of liver cancer cases and is primarily linked to factors incluidng aflatoxin, hepatitis B (HBV) and C (HCV), and... |
39915445 | Mutant glycosidases for labeling sialoglycans with high specificity and affinity. | Affinity labeling of biomacromolecules is vital for bioimaging and functional studies. However, affinity probes recognizing glycans with high specificity remain scarce. Here we report the development of glycan recombinant affinity binders (GRABs) based on mutant bacterial sialidases, which are enzymatically inactive bu... |
39878324 | Putting Charge Transfer Degree as a Bridge Connecting Surface-Enhanced Raman Spectroscopy and Photocatalysis. | To date, few systematic approach has been established for predicting catalytic performance by analyzing the spectral information of molecules adsorbed on photocatalyst surfaces. Effective charge transfer (CT) between the semiconductor photocatalysts and surface-absorbed molecules is essential for enhancing catalytic ac... |
39874178 | Nanopore-Based High-Resolution Detection of Multiple Post-Translational Modifications in Protein. | Protein post-translational modifications (PTMs) play crucial roles in various cellular processes. Despite their significance, only a few PTMs have been extensively studied at the proteome level, primarily due to the scarcity of reliable, convenient, and low-cost sensing methods. Here, we present a straightforward and e... |
39873333 | Topological Supramolecular Complexation of Metal-Organic Polyhedra for Tunable Interconnected Hierarchical Microporosity in Amorphous Form. | The precise engineering of microporosity is challenging due to the interference at the sub-nm scale from unexpected structural flexibility and molecular packing. Herein, the concept of topological supramolecular complexation is proposed for the feasible fabrication of hierarchical microporosity with broad tunability in... |
39868876 | Axially Chiral TADF Imidazolium Salts for Circularly Polarized Light-Emitting Electrochemical Cells. | A pair of axially chiral thermally activated delayed fluorescent (TADF) enantiomers, R-TCBN-ImEtPF<sub>6</sub> and S-TCBN-ImEtPF<sub>6</sub>, with intrinsic ionic characteristics were efficiently synthesized by introducing imidazolium hexafluorophosphate to chiral TADF unit. The TADF imidazolium salts exhibited a high ... |
39865547 | Surface Hydroxylated S/O Dual-Vacancy S-Scheme Hollow [In<sub>2</sub>S<sub>3-x</sub>/In<sub>2</sub>O<sub>3-x</sub>](OH)<sub>y</sub> Heterojunction for Photothermal-promoted Low-Temperature Methanol/Water Reforming into Hydrogen. | To enable highly efficient in situ hydrogen release from methanol/water reforming at lower temperature, the integration of solar-energy offers a promising approach to activate methanol/water and substantially lower the activation energy of this reaction. Herein, we present a novel dual-vacancy defective hollow heterost... |
39865527 | Two Consecutive Pathways Competing for Supramolecular Polymerization of Naphthalene-Diimide Molecules. | The final outcomes of supramolecular assembly are determined by the pathways and the formation of intermediates during the assembly process. We studied pathway complexity involving two consecutive pathways in supramolecular polymerization of naphthalene-diimide (NDI) derivative molecule. Depending on preparation method... |
39829246 | Tuning Optical Properties of Organic Thin Films through Intermolecular Interactions - Fundamentals, Advances and Strategies. | In applications ranging from photon-energy conversion into electrical or chemical forms (such as photovoltaics or photocatalysis) to numerous sensor technologies based on organic solids, the role of supramolecular structures and chromophore interactions is crucial. This review comprehensively examines the critical inte... |
41140511 | Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric nanoparticles. | Cytotoxic agents targeting the epidermal growth factor receptor (EGFR) exhibit significant potential for cancer therapy as EGFR is overexpressed in various cancers. As alternatives to conventional EGFR inhibitors (EGFRi), which exert side effects on non-cancer cells, EGF-immobilized gold nanoparticles exhibit selective... |
40657187 | Femtosecond-Laser Preparation of Hydrogel with Micro/Nano-Structures and their Biomedical Applications. | Hydrogels with micro/nano-structures precisely prepared by femtosecond-laser processing technology are biomaterials that mimic the natural extracellular matrix and can achieve the precise regulation of biological properties, such as cell behavior and structural-mechanical properties. They also play a crucial role in bi... |
40175047 | Pharmacophore modeling in drug design. | A successful and expanded area of computational drug design is pharmacophore modeling. A pharmacophore is a description of the structural features of a compound that are essential to its biological activity. The rational design of new drugs has made extensive use of the pharmacophore concept. By schematically illustrat... |
40104113 | A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain. | Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to the brain. We have explored a combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection for crossing the BBB. We incorporated mannitol in the PBAE polymer for caveolae t... |
40037726 | Development of multifunctional starch/pectin composite film engineered with ZIF-67-loaded microcrystalline cellulose for real-time monitoring and preserving of pork freshness. | The escalating environmental concerns associated with plastic waste have driven the need for sustainable food packaging solutions. In this study, a multifunctional composite film was developed to simultaneously monitor and preserve pork freshness. The film was based on loquat seed starch (LSS) as the matrix, pectin (P)... |
40027441 | Biotechnological tools boost the functional diversity of DNA-based data storage systems. | DNA-based data storage has emerged as a groundbreaking solution to the growing demand for efficient, high-density, and long-term data storage. It is attracting many researchers' attention, who are implementing functions such as random access, searching, and data operations apart from the existing capabilities, includin... |
40026394 | Decoding interactions between biofilms and DNA nanoparticles. | Biofilms present a great challenge in antimicrobial therapy due to their inherent tolerance to conventional antibiotics, promoting the need for advanced drug delivery strategies that improve therapy. While various nanoparticles (NPs) have been reported for this purpose, DNA-based NPs remain a largely unexploited resour... |
40018390 | Recent Advances in Probing Electron Delocalization in Conjugated Molecules by Attached Infrared Reporter Groups for Energy Conversion and Storage. | This review article reports an overview of the recent developments in the field of electron delocalization study in organic conjugated molecules by utilizing the vibration frequencies exhibited by the attached functional groups such as nitrile (-C≡N), alkyne (-C≡C-), or carbonyl (-C=O). A brief introduction to electron... |
40017777 | Emerging Trends in DNA Nanotechnology-Enabled Cell Surface Engineering. | Cell surface engineering is a rapidly advancing field, pivotal for understanding cellular physiology and driving innovations in biomedical applications. In this regard, DNA nanotechnology offers unprecedented potential for precisely manipulating and functionalizing cell surfaces by virtue of its inherent programmabilit... |
40017740 | Alkynyl Radicals, Myths and Realities. | This Perspective deals with the organic chemistry of alkynyl radicals, a species that is ultimately still little known in the synthetic community. Starting with the first observations and characterizations of alkynyl radicals generated by various methodologies in the gas phase, we then particularly turned our attention... |
40013154 | Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies. | Sepsis, a heterogeneous illness produced by a dysregulated host response to infection, remains a severe mortality risk. Recent discoveries in sepsis research have stressed phenotyping as a feasible strategy for tackling heterogeneity and enhancing therapy precision. Sepsis phenotyping has moved from traditional stratif... |
40008198 | Pinpointing Cu-Coordination Motifs in Bio-Inspired MOFs by Combining DFT-Assisted XAS Analysis and Multivariate Curve Resolution. | In recent years, X-ray absorption spectroscopy (XAS) has emerged as an essential technique for investigating the structure and composition of heterogeneous catalysts, providing valuable insights into the nature of active sites within these systems. However, the average nature of the XAS signal, inherently merged over a... |
40008194 | Plasmonic Chirality Meets Reactivity: Challenges and Opportunities. | The unique optoelectronic features associated with plasmonic nanomaterials in a broad energy range of the electromagnetic spectrum have the potential to overcome the current limitations in the development of heterogeneous photocatalytic systems with enantioselective capabilities. Recent advancements in creating plasmon... |
40006573 | PLGA-Based Strategies for Intranasal and Pulmonary Applications. | Poly(D,L-lactide-co-glycolide) (PLGA) has emerged as a cornerstone in the development of advanced drug delivery systems, particularly for intranasal and pulmonary routes. Its biodegradability, biocompatibility, and adaptability make it an ideal platform for addressing challenges associated with conventional therapies. ... |
40006574 | Nanostructured Formulations for a Local Treatment of Cancer: A Mini Review About Challenges and Possibilities. | Cancer represents a significant societal, public health, and economic challenge. Conventional chemotherapy is based on systemic administration; however, it has current limitations, including poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, and the development of multiple drug... |
40006569 | Preparing a Liposome-Aided Drug Delivery System: The Entrapment and Release Profiles of Doxorubicin and 9-(<i>N</i>-Piperazinyl)-5-methyl-12(<i>H</i>)-quino [3,4-b][1,4]benzothiazinium Chloride with Human Serum Albumin. | <b>Background/Objectives:</b> The principal aim of this work was to prepare a liposomal drug delivery system based on the commercial drug doxorubicin (DOX) and a budding agent with promising anticancer activity, 9-(<i>N</i>-piperazinyl)-5-methyl-12(<i>H</i>)-quino [3,4-b][1,4]benzothiazinium chloride (9-PBThACl). <b>Me... |
40006571 | Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview. | Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins. The vast diversity of snake species and their venom complexities underline the need for ongoing research. This review is dedicated to exploring the... |
40006577 | Thymoquinone-Loaded Chitosan Nanoparticles Combat Testicular Aging and Oxidative Stress Through SIRT1/FOXO3a Activation: An In Vivo and In Vitro Study. | <b>Background:</b> Aging is a complex biological process characterized by the accumulation of molecular and cellular damage over time, often driven by oxidative stress. This oxidative stress is particularly detrimental to the testes, where it causes degeneration, reduced testosterone levels, and compromised fertility. ... |
40006568 | Non-Invasive Delivery of CRISPR/Cas9 Ribonucleoproteins (Cas9 RNPs) into Cells via Nanoparticles for Membrane Transport. | The clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system is a promising biotechnology tool for genome editing. However, in living organisms, several pharmacokinetic challenges arise, including off-target side effects due to incorrect distribution, low bioavailabilit... |
40002808 | Role of the AIM2 Inflammasome in Cancer: Potential Therapeutic Strategies. | Absent in melanoma 2 (AIM2) is a member of the innate immune sensors that recognizes cytosolic nucleic acids, leading to inflammasome assembly. In recent years, several studies in the oncology field have highlighted the presence of cytoplasmic double-stranded DNA (dsDNA) following necrosis and/or genomic instability, w... |
39997679 | Advances in Ceramic-Carbonate Dual-Phase Membrane Reactors for Direct CO<sub>2</sub> Separation and Utilization. | Excessive (carbon dioxide) CO<sub>2</sub> emissions are a primary factor contributing to climate change. As one of the crucial technologies for alleviating CO<sub>2</sub> emissions, carbon capture and utilization (CCU) technology has attracted considerable global attention. Technologies for capturing CO<sub>2</sub> in ... |
39997190 | RNA Editing Analysis Reveals Methyl Jasmonic Acid Regulation of Fucoxanthin and Fatty Acid Metabolism in <i>Phaeodactylum tricornutum</i>. | <i>Phaeodactylum tricornutum</i> is a marine diatom with significant biotechnological potential, particularly in producing high-value bioactive compounds such as fucoxanthin and unsaturated fatty acids, which possess significant pharmaceutical and nutraceutical properties. However, the naturally low yields of these com... |
39996664 | Characteristics of Polybenzoxazine Aerogels as Thermal Insulation and Flame-Retardant Materials. | Polybenzoxazine-based aerogels are a unique class of materials that combine the desirable properties of aerogels-such as low density, high porosity, and excellent thermal insulation-with the outstanding characteristics of polybenzoxazines-such as high thermal stability, low water absorption, and superior mechanical str... |
39996660 | Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs. | In this study, we report the synthesis and characterization of aminated poly(methyl silsesquioxane)-based hydrogels ((AP/MS)SO-hydrogels) as potential enzyme-sensitive vehicles for antianemic drugs. The hydrogels were synthesized via sol-gel polymerization and functionalized with amine groups. Characterization techniqu... |
39996657 | Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications. | Silk sericin (SS), a by-product of the textile industry, has gained significant attention for its biomedical potential due to its biocompatibility and regenerative potential. However, the literature lacks information on SS processing methods and the resulting physicochemical properties. This study represents the first ... |
39991688 | Ferromagnetic Interactions within a Dimer of a π-Extended 1,2,4-Benzotriazin-4-yl. | 1,3,7-Triphenyl-4,8-dihydro-1<i>H</i>-imidazo[4,5-<i>g</i>][1,2,4]benzotriazin-4-yl, a stable radical, forms 1 D π stacks. These stacks consist of dimers with alternating interplanar distances measuring 3.443 Å (short) and 4.169 Å (long). Magnetic susceptibility (χ<i>T</i>) reaches its peak at 18 ± 4 K, signifying the ... |
39989831 | Search for Correlations Between the Results of the Density Functional Theory and Hartree-Fock Calculations Using Neural Networks and Classical Machine Learning Algorithms. | This work proposes several machine learning models that predict B3LYP-D4/def-TZVP outputs from HF-3c outputs for supramolecular structures. The data set consists of 1031 entries of dimer, trimer, and tetramer cyclic structures, containing both molecules with heteroatoms in the ring and without. Six quantum chemistry de... |
39989757 | Site-Specific Functionalization of Recombinant Spider Silk Using Enzymatic Sortase Coupling. | Functionalization of biomaterials with extra protein domains will expand their functional roles in biomedical research. The recombinant spider silk protein FN-4RepCT has been shown able to adapt various formats like coatings, nanowires, and macroscopic fibers. Functionalizing these various formats of FN-4RepCT in a sit... |
39989755 | Rapid and On-Site Approaches for Determination of Polycyclic Aromatic Hydrocarbons in Water and Air by Surface-Enhanced Raman Spectroscopy. | Polycyclic aromatic hydrocarbons (PAHs) represent a class of carcinogenic, teratogenic, and mutagenic aromatic organic pollutants that are ubiquitous in the environment. The rapid and on-site detection of PAHs remains a challenge. This study proposes point-of-use (POU) surface-enhanced Raman spectroscopy (SERS)-based s... |
39982229 | Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice. | <h4>Background/objectives</h4>A mouse antibody directed against truncated Annexin A1 showed high tumor retention in pre-clinical cancer models and was approved by the National Cancer Institute Experimental Therapeutics (NExT) program for humanization and large batch cGMP production for toxicology and clinical trials. I... |
39981379 | Inhibition of early EHDV2-Ibaraki infection steps in bovine cells by endosome alkalinization or ikarugamycin, but not by blockage of individual endocytic pathways. | The Epizootic hemorrhagic disease virus (EHDV), an orbivirus, is the etiological factor of a fatal hemorrhagic disease of wild ruminants. A subset of EHDV serotypes, including the Ibaraki strain of EHDV2 (EHDV2-Ibaraki), infect and cause disease in cattle, thus posing a potential threat to livestock. As a member of the... |
39981265 | Advances in micro-/nanorobots for cancer diagnosis and treatment: propulsion mechanisms, early detection, and cancer therapy. | In recent years, medical micro-/nanorobots (MNRs) have emerged as a promising technology for diagnosing and treating malignant tumors. MNRs enable precise, targeted actions at the cellular level, addressing several limitations of conventional cancer diagnosis and treatment, such as insufficient early diagnosis, nonspec... |
39946868 | Rapid bacterial detection through microfluidic integration with a glucometer. | We present a novel approach for sensitive and portable detection of pathogenic bacteria, which is crucial for household and clinical practice. Our method employs immunoliposomes, antibodies, and microchip to detect specific pathogens quantitatively. Gold and metal metal-organic nanoparticles and liposomes were characte... |
39946754 | Novel Siglec-1/β-CD/rGO impedimetric biosensor for detecting Neu5Ac expression in red blood cells. | This study introduces a beta-cyclodextrin/reduced graphene oxide/indium tin oxide (β-CD/rGO/ITO) microelectrode platform for the real-time, non-invasive, and label-free detection of N-acetylneuraminic acid (Neu5Ac) on red blood cell (RBC) surfaces. By leveraging advances in CRISPR-Cas9 technology, genetically modified ... |
39946753 | In situ pH-Controlled electrochemical sensors for glucose and pH detection in calf saliva. | Electrochemical biosensors have been extensively researched and employed across diverse fields from environmental monitoring to clinical diagnostics. Detecting biomarkers like saliva pH and glucose are crucial indicators of the health and well-being of animals and opens the door for development of new non-invasive calf... |
39943225 | Risk Assessment of Global Animal Melioidosis Under Current and Future Climate Scenarios. | Melioidosis is a zoonotic disease that is caused by <i>Burkholderia pseudomallei</i>, which is a serious public health and safety risk. In order to explore the global animal melioidosis risk distribution and its dynamic response to future climate scenarios, we collected global data about reported animal incidence sites... |
39943227 | Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures. | Reptiles, birds, mammals and amphibians, together forming the clade tetrapods, have a large diversity of cornified skin appendages, such as scales, feathers, hair and claws. The skin appendages consist of dead epithelial cells that are tightly packed with specific structural proteins. Here, we review the molecular dive... |
39943054 | L-Theanine Metabolism in Tea Plants: Biological Functions and Stress Tolerance Mechanisms. | L-theanine, a unique non-protein amino acid predominantly found in tea plants (<i>Camellia sinensis</i>), plays a pivotal role in plant responses to abiotic stress and significantly influences tea quality. In this review, the metabolism and transport mechanisms of L-theanine are comprehensively discussed, highlighting ... |
39942840 | Raman Spectroscopy of Fullerenes: From C<sub>60</sub> to Functionalized Derivatives. | Fullerenes, a unique allotrope of carbon, have captured significant attention in multiple scientific fields. As a non-destructive characterization technique, Raman spectroscopy has proven indispensable for investigating fullerenes and their derivatives, offering detailed insights into their vibrational properties. This... |
39942834 | Synthesis and Characterization of a Two-Station Two-Gate Calix[6]arene-Based [2]Catenane. | The design, construction, and operation of devices and machines at the molecular scale using the bottom-up approach captivates a lot of interest in nanoscience. Particularly intriguing are interlocked molecular architectures, which are ideal candidates for these aims. [n]Pseudorotaxanes, [n]rotaxanes, and [n]catenanes ... |
39942392 | Protein Cage-like Vesicles Fabricated via Polymerization-Induced Microphase Separation of Amphiphilic Diblock Copolymers. | Highly symmetric protein cages represent one of the most artistic architectures formed by biomolecules. However, the underlying reasons for the formation of some of these architectures remain unknown. The present study aims to investigate the significance behind their morphological formation by fabricating protein cage... |
39942391 | The Effect of A-Cation and X-Anion Substitutions on the Electronic and Structural Properties of A<sub>2</sub>ZrX<sub>6</sub> 'Defect' Perovskite Materials: A Theoretical Density Functional Theory Study. | In the present work, nine 'defect' perovskites with the chemical formula A<sub>2</sub>ZrX<sub>6</sub> have been studied, where the A-site cations are a methylammonium cation, formamidinium cation, and trimethyl-sulfonium cation and the X-site anions are halogen, X = Cl, Br, and I. We employ periodic DFT calculations us... |
39942131 | Self-Enhanced Near-Infrared Copper Nanoscale Electrochemiluminescence Probe for the Sensitive Detection of Ciprofloxacin in Foods. | Ciprofloxacin (CIP), a widely used broad-spectrum antibiotic, poses a serious threat to human health and environmental safety due to its residues. The complementary monomers molecularly imprinted electrochemiluminescence sensor (MIECLS) based on a polyvinylpyrrolidone-functionalized copper nanowires (CuNWs@PVP) lumines... |
39942124 | Identification of a TonB-Dependent Siderophore Receptor as a Novel Anti-Biofilm Target and Virtual Screening for Its Inhibitor in <i>Pseudomonas fluorescens</i> PF08. | <i>Pseudomonas fluorescens</i> is a vital food spoilage bacterium that commonly spoils foods in the biofilm state. Uncovering the targets responsible for biofilm formation and disrupting their function is a promising way to control bacterial biofilms and food spoilage. In this work, using the combination of qRT-PCR and... |
39941153 | Antibiofilm Activities of Halogenated Pyrimidines Against Enterohemorrhagic <i>Escherichia coli</i> O157:H7. | Enterohemorrhagic <i>Escherichia coli</i> (EHEC) is a significant public health concern due to its ability to form biofilms, enhancing its resistance to antimicrobials and contributing to its persistence in food processing environments. Traditional antibiotics often fail to target these biofilms effectively, leading to... |
39941152 | The NbCBP1-NbSAMS1 Module Promotes Ethylene Accumulation to Enhance <i>Nicotiana benthamiana</i> Resistance to <i>Phytophthora parasitica</i> Under High Potassium Status. | Potassium (K) fertilization is crucial for plant resistance to pathogens, but the underlying mechanisms remain unclear. Here, we investigate the molecular mechanism by which the addition of K promotes resistance in <i>Nicotiana benthamiana</i> to <i>Phytophthora parasitica</i>. We found that <i>N. benthamiana</i> with ... |
39941148 | Molecular Simulation of the Binding of Amyloid Beta to Apolipoprotein A-I in High-Density Lipoproteins. | Disrupted clearance of amyloid beta (Aβ) from the brain enhances its aggregation and formation of amyloid plaques in Alzheimer's disease. The most abundant protein constituent of circulating high-density lipoprotein (HDL) particles, apoA-I, readily crosses the blood-brain barrier from periphery circulation, exhibits lo... |
39941144 | Modification in Structures of Active Compounds in Anticancer Mitochondria-Targeted Therapy. | Cancer is a multifaceted disease characterised by uncontrolled cellular proliferation and metastasis, resulting in significant global mortality. Current therapeutic strategies, including surgery, chemotherapy, and radiation therapy, face challenges such as systemic toxicity and tumour resistance. Recent advancements ha... |
39941135 | Impact of African-Specific ACE2 Polymorphisms on Omicron BA.4/5 RBD Binding and Allosteric Communication Within the ACE2-RBD Protein Complex. | Severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) infection occurs via the attachment of the spike (S) protein's receptor binding domain (RBD) to human ACE2 (hACE2). Natural polymorphisms in hACE2, particularly at the interface, may alter RBD-hACE2 interactions, potentially affecting viral infectivity across ... |
39941127 | The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting. | Dihydroorotase (DHOase; EC 3.5.2.3) is a zinc-dependent metalloenzyme that plays a key role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of <i>N</i>-carbamoyl aspartate to dihydroorotate. This reaction is essential for the production of uridine monophosphate, the precursor of al... |
39940225 | Deriving High-Energy-Density Polymeric Nitrogen N<sub>10</sub> from the Host-Guest ArN<sub>10</sub> Compound. | Discovering stable polymeric nitrogen phases and exploring their properties are crucial for energy storage and conversion, garnering significant attention. In this study, we investigate the formation possibility of a stable compound between Ar and N<sub>2</sub> through ab initio calculations under low-pressure conditio... |
39935507 | Inverse opal anatase/rutile TiO<sub>2</sub> multi-heterojunctions enable efficient photoelectrochemical water splitting. | TiO<sub>2</sub> has garnered significant attention in the field of photoelectrochemical (PEC) water splitting due to its non-toxicity, cost-effectiveness, and exceptional photochemical stability. However, its practical efficiency in H<sub>2</sub> production is greatly hindered by inherent limitations such as low electr... |
39931526 | Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation. | <h4>Background</h4>A paramount issue in the realm of chronic wound healing among diabetic patients is the pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays in the healing process of such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug de... |
39929013 | Unveiling the reaction mechanism of photocatalytic H<sub>2</sub> evolution coupled with selective bio-mass monosaccharide upgrading over single palladium atom-engineered carbon-rich graphitic carbon nitride. | The simultaneous utilization of photogenerated electrons and holes in the coupled redox reactions of H<sub>2</sub> production and selective biomass upgrading is a promising strategy to offer both economic and environmental benefits. Nevertheless, the method faces challenges of low H<sub>2</sub> evolution efficiency and... |
39926712 | Host-guest chemistry on living cells enabling recyclable photobiocatalytic cascade. | Combining chemical and whole-cell catalysts enables sustainable chemoenzymatic cascade reactions. However, their traditional combination faces challenges in catalyst recycling and maintaining cell viability. Here, we introduce a supramolecular host-guest strategy that efficiently attaches photocatalysts to bacterial ce... |
39926241 | Engineering the structures of ZnCo-MOFs <i>via</i> a ligand effect for enhanced supercapacitor performance. | Tuning the structures, compositions and morphologies of metal-organic frameworks (MOFs) is critical to boosting their supercapacitor performances. In this study, a ligand-engineering strategy was adopted to fabricate ZnCo-bimetallic MOFs with unique properties using three different ligands (2-methylimidazole, terephtha... |
39925737 | Recent progress in emerging molecular targeted therapies for intrahepatic cholangiocarcinoma. | Cholangiocarcinoma (CCA) is a diverse group of epithelial malignant tumors arising from the biliary tract, characterized by high molecular heterogeneity. It is classified into intrahepatic (iCCA) and extrahepatic CCA (eCCA) based on the location of the primary tumor. CCA accounts for approximately 15% of all primary li... |
39922494 | Structure of a mutated photosystem II complex reveals changes to the hydrogen-bonding network that affect proton egress during O-O bond formation. | Photosystem II (PSII) is the water-splitting enzyme of oxygenic photosynthesis. Using light energy, PSII catalytically oxidizes two water molecules to fuel downstream metabolism, forming an O-O bond and releasing O<sub>2</sub> as a byproduct. The reaction mechanism requires the strategic removal of four protons via con... |
39922493 | Charge screening and hydrophobicity drive progressive assembly and liquid-liquid phase separation of reflectin protein. | The intrinsically disordered reflectin proteins drive tunable reflectivity for dynamic camouflage and communication in the recently evolved Loliginidae family of squid. Previous work revealed that reflectin A1 forms discrete assemblies whose size is precisely predicted by protein net charge density and charge screening... |
39922445 | Lipopolysaccharide supramolecular organization regulates the activation of coagulation factor XII. | Lipopolysaccharides (LPS) are key bacterial membrane components that activate coagulation factor XII (FXII), establishing a critical link between bacterial infections, blood coagulation, and inflammation. This study investigates how the supramolecular organization of LPS-monomers, micelles, and bilayers-affects FXII ac... |
39916518 | Formation of CdTeS Prenucleation Clusters at Elevated Temperatures and Transformation to Magic-Size Clusters at Room Temperature. | The synthesis of colloidal semiconductor magic-size clusters (MSCs) of ternary II-VI metal chalcogenide (ME<sub>1</sub>E<sub>2</sub>) remains challenging. Using CdTeS as a model system, it is shown that CdTeS MSC-381 (displaying sharp optical absorption peaking at 381 nm) develops at room temperature from prenucleation... |
39916476 | Artificial Intelligence in Natural Product Drug Discovery: Current Applications and Future Perspectives. | Drug discovery, a multifaceted process from compound identification to regulatory approval, historically plagued by inefficiencies and time lags due to limited data utilization, now faces urgent demands for accelerated lead compound identification. Innovations in biological data and computational chemistry have spurred... |
39916335 | Alkali Induction Strategy for Artificial Photosynthesis of Hydrogen by TiO<sub>2</sub> Heterophase Homojunctions. | The robust separation and utilization of photogenerated electrons-holes (e<sup>-</sup>-h<sup>+</sup>) are key in accelerating redox reactions. Unlike traditional heterojunction photocatalysts, homojunction features different energy bandgaps with interchangeable compositions that can significantly trigger charge carrier... |
39915976 | Guanosine enhances the bactericidal effect of ceftiofur sodium on <i>Streptococcus suis</i> by activating bacterial metabolism. | The emergence and rapid development of antibiotic resistance poses a serious threat to global public health. <i>Streptococcus suis</i> (<i>S. suis</i>) is an important zoonotic pathogen, and the development of its antibiotic resistance has made the infections difficult to treat. The combination of non-antibiotic compou... |
39915932 | Environmental stimuli-responsive hydrogels in endodontics: Advances and perspectives. | Stimuli-responsive hydrogels are smart and functional materials that respond to various environmental stimuli, including temperature, light, magnetic field, pH, redox, enzymes and glucose. This responsiveness allows for the controlled release of therapeutic agents encapsulated within the hydrogels, enhancing treatment ... |
39915791 | Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization. | Nanobodies (Nbs), miniature antibodies consisting solely of the variable region of heavy chains, exhibit unique properties such as small size, high stability, and strong specificity, making them highly promising for disease diagnosis and treatment. The engineering production of Nbs has evolved into a mature process, in... |
39915767 | Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics. | Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, and tumors. While they help capture and eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage and disease progression. Therapeutic strategie... |
39915474 | Efficiently regulating the electrochromic behavior of naphthalene-diimide-based zirconium-organic frameworks through linker installation. | Redox-active metal-organic frameworks (MOFs) have already demonstrated their unique advantages in the field of electrochromism over the past decade. However, controlling and modulating the electrochromic behaviors in specific MOFs remains a significant challenge, as most of the cases reported so far are achieved by des... |
39915004 | Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality. | <h4>Background</h4>Natural Killer (NK) cells have intrinsic anticancer activity that can be redirected toward acute myeloid leukemia (AML) with chimeric antigen receptor (CAR) engineering. Here, we study the functional consequences of CAR binding affinity and targeted epitope on CAR-NK cell activation, cytolytic synaps... |
39914892 | Engineered Shape-Tunable Copper-Coordinated Nanoparticles for Macrophage Reprogramming. | The immune system safeguards as primary defense by recognizing nanomaterials and maintaining homeostasis, gaining a deeper understanding of these interactions may change the treating paradigm of immunotherapy. Here, we adopted copper as the principal component of nanoparticles (NPs), given its features of coordination ... |
39914804 | Comparative Kinetics of Supported Lipid Bilayer Formation on Silica Coated Vertically Oriented Highly Curved Nanowires and Planar Silica Surfaces. | Supported lipid bilayers (SLBs), formed via lipid vesicle adsorption on highly curved silica surfaces, are widely used in biosensor applications and as models for curved cell membranes. However, SLB formation is often hindered on convex structures with radii comparable to the vesicles. In this study, lightguiding semic... |
39914796 | Computational Analysis of the Lewis Acid-Catalyzed Zwitterionic Ring-Expansion Polymerization (ZREP) of Monosubstituted Ethylene Oxide. | This study investigates the reaction mechanism of the zwitterionic ring expansion polymerization (ZREP) of monosubstituted ethylene oxide using boron-based Lewis acids as catalysts to produce cyclic polyethers. The research analyzes various parameters, such as the nature of the substituents (electron-withdrawing, EWG o... |
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