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39913943 | Three Polyoxovanadoborates Constructed from "Sandwich"-Type {V<sub>10</sub>B<sub>24</sub>}, {V<sub>10</sub>B<sub>28</sub>}, and {V<sub>12</sub>B<sub>32</sub>} Clusters. | Three distinct polyoxovanadoborates modified by transition metals, specifically {V<sub>10</sub>B<sub>26</sub>Cd<sub>8</sub>(phen)<sub>12</sub>} (<b>1</b>, phen = 1,10-phenanthroline), {V<sub>10</sub>B<sub>32</sub>Zn<sub>6</sub>} (<b>2</b>), and {V<sub>12</sub>B<sub>32</sub>Cu<sub>2</sub>} (<b>3</b>), have been synthesi... |
39913867 | Solid State Self-Assembly of an Extended Curved-Arm Nickel(II) Macrocycle with Fullerene C<sub>60</sub>. | Three new co-crystalline structures are reported that contain fullerene C<sub>60</sub> with the under-represented Ni(II)-dibenzotetraaza[14]annulene derivative, (5,14-dihydro-6,8,15,17-tetrabenzyl-2,3,11,12-tetramethyldibenzo[b,i][1,4,8,11]tetraazacyclo-tetradecine)nickel(II), [Ni(Bz<sub>4</sub>TMTAA)]. The single-crys... |
39913455 | Utilizing the subtractive proteomics approach to design ensemble vaccine against Candida lusitaniae for immune response stimulation; a bioinformatics study. | Vaccines have always been one of the promising therapeutic sources against many pathogens including infectious fungi. Candida lusitaniae is also one of those fungi which is responsible for different infections in human beings including vaginitis, endocarditis, endophthalmitis and blood stream infections. There is thus,... |
39913383 | Identification and prioritization of novel therapeutic candidates against glutamate racemase from Klebsiella pneumoniae. | <h4>Background</h4>Klebsiella pneumoniae, a gram-negative bacterium in the Enterobacteriaceae family, is non-motile, encapsulated, and a major cause of nosocomial infections, particularly in intensive care units. The bacterium possesses a thick polysaccharide capsule and fimbriae, which contribute to its virulence, res... |
39913309 | Hierarchical Fibrous Metal-Organic Framework/Ionic Liquid Membranes for Efficient CO<sub>2</sub>/N<sub>2</sub> Separation. | The structural diversity and chemical functionality of metal-organic frameworks (MOFs) render them promising candidates for CO<sub>2</sub> adsorption and separation. However, their applications are often restricted by their intrinsic fragility and decreased processability. Herein, a hierarchical fibrous MOF/ionic liqui... |
39913266 | Metal-Phenolic Network (MPN) Modified Janus Fibrous Hydrogel Scaffold for Infected Diabetic Wound Healing. | Management of infected diabetic wounds with large amounts of biofluid is challenging to treat due to localized edema-induced ischemia. Traditional hydrophilic dressings retain wound exudate, raise bacterial infection, and hinder wound healing. Herein, a multifunctional double-layer Janus fibrous hydrogel with a hydroph... |
39913243 | Molecular Dynamics Simulation of Structural Assembly and Hydration of Hyaluronic Acid in Salt Aqueous Buffer. | Hyaluronic acid (HA) is a nonsulfonated glycosaminoglycan critical in tissue development, physiology, and disease processes. To develop biomimetic in vitro models based on HA, it is important to understand the interaction of this polymer in its pristine form and with physiological solvents. However, atomistic simulatio... |
39913238 | easyPARM: Automated, Versatile, and Reliable Force Field Parameters for Metal-Containing Molecules with Unique Labeling of Coordinating Atoms. | The dynamics of metal centers are challenging to describe due to the vast variety of ligands, metals, and coordination spheres, hampering the existence of general databases of transferable force field parameters for classical molecular dynamics simulations. Here, we present easyPARM, a Python-based tool that can calcul... |
39913003 | Pharmacogenomics influence on MDR1-associated cancer resistance and innovative drug delivery approaches: advancing precision oncology. | Currently, there is a growing concern surrounding the treatment of cancer, a formidable disease. Pharmacogenomics and personalized medicine have emerged as significant areas of interest in cancer management. The efficacy of many cancer drugs is hindered by resistance mechanisms, particularly P-glycoprotein (P-gp) efflu... |
39912994 | Multifunctional Janus-Structured Polytetrafluoroethylene-Carbon Nanotube-Fe<sub>3</sub>O<sub>4</sub>/MXene Membranes for Enhanced EMI Shielding and Thermal Management. | Herein, a novel Janus-structured multifunctional membrane with integrated electromagnetic interference (EMI) shielding and personalized thermal management is fabricated using shear-induced in situ fibrillation and vacuum-assisted filtration. Interestingly, within the polytetrafluoroethylene (PTFE)-carbon nanotube (CNT)... |
39912967 | Artificial Intelligence-Powered Materials Science. | The advancement of materials has played a pivotal role in the advancement of human civilization, and the emergence of artificial intelligence (AI)-empowered materials science heralds a new era with substantial potential to tackle the escalating challenges related to energy, environment, and biomedical concerns in a sus... |
39912952 | Fluorine-fluorine interaction-driven colorimetric sensor for PFOA-sensitive detection using F-functionalized Ce-UiO-66-NH<sub>2</sub> MOF with oxidase-like activity. | A novel colorimetric sensor was designed for sensitive perfluorooctanoic acid (PFOA) detection based on a fluorine-functionalized Ce-metal-organic framework (F-Ce-UiO-66-NH<sub>2</sub>) with oxidase-like activity, using 3,3',5,5'-tetramethylbenzidine (TMB) as the chromogenic substrate. This F-Ce-UiO-66-NH<sub>2</sub> w... |
39912804 | Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter. | <i>N</i> -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates. Some bacteria scavenge, import, and metabolize Neu5Ac or redeploy it on their cell surfaces for immune evasion. The import of Neu5Ac by many bacteria is medi... |
39912791 | Responsive Magnetic Polymer Nanocomposites through Thermal-Induced Structural Reorganization. | Polymer nanocomposites (PNCs), which feature a hybrid network of soft polymers filled with nanoparticles, hold promise for application in soft robots due to their tunable physiochemical properties. Under certain environmental conditions, PNCs undergo stimuli-responsive structural rearrangement and transform the energy ... |
39912785 | C10-Benzoate Esters of Anhydrotetracycline Inhibit Tetracycline Destructases and Recover Tetracycline Antibacterial Activity. | Tetracyclines (TCs) are an important class of antibiotics threatened by enzymatic inactivation. These tetracycline-inactivating enzymes, also known as tetracycline destructases (TDases), are a subfamily of class A flavin monooxygenases (FMOs) that catalyze hydroxyl group transfer and oxygen insertion (Baeyer-Villiger t... |
39912766 | Generation of Advanced Blood-Brain Barrier Spheroids Using Human-Induced Pluripotent Stem Cell-Derived Brain Capillary Endothelial-Like Cells. | Extensively studied blood-brain barrier (BBB) in-vitro models are established on 2D cell culture inserts. However, they do not accurately represent 3D in-vivo microenvironments due to lack of direct neurovascular unit cellular contacts. Here, the establishment and characterization of a self-assembled 3D BBB spheroid mo... |
39912756 | Azo-Bridged Dextran: A Photoresponsive Sustainable Material with Photo-Tunable Mechanical Properties. | We report on the synthesis, characterization, and properties of dextran polymers, which are covalently bridged/cross-linked by azobenzene moieties. The reversible photoactivity of the azo moiety is retained in the polymers, and the kinetics of the <i>E</i>/<i>Z</i> isomerization depend on the dextran/azobenzene ratio. ... |
39912750 | <sup>1</sup>H NMR Trajectories for Analyzing the Growth and Purification of 2D Polyaramids. | The recent synthesis of two-dimensional (2D) polyaramid (PA) polymers has shown that they exhibit remarkable mechanical and gas barrier properties. However, new methods are necessary to enable the efficient measurement of discoidal sizes of 2D polyaramids and tracking of their growth over time during reaction. Herein, ... |
39912667 | Conformational activation and disulfide exchange in HIV-1 Env induce cell-free lytic/fusogenic transformation and enhance infection. | Disulfide exchange is underexplored as a mechanism influencing HIV-1 entry. Prior studies demonstrated that redox enzyme inhibition can prevent HIV-1 infection but with limited mechanistic explanation. We hypothesize that ligand-driven rearrangement ("conformational activation") enables enzyme-mediated disulfide exchan... |
39912644 | Effects of Sup35 overexpression on the formation, morphology, and physiological functions of intracellular Sup35 assemblies. | The yeast prion protein Sup35 is aggregation-prone at high concentrations. <i>De novo</i> Sup35 prion formation occurs at a significantly increased rate after transient overexpression of Sup35 in the presence of another prion, [<i>PIN</i><sup>+</sup>], but it is still a rare event. Recent studies uncovered an additiona... |
39912546 | 3D Electron Diffraction Structure of an Organic Semiconductor Reveals Conformational Polymorphism. | Crystal and conformational polymorphisms play crucial roles in the physical and chemical properties of materials, impacting their stability, solubility, and bioavailability, which are essential for various applications in pharmaceuticals, materials science, and chemistry. Despite their significance, the structural anal... |
39912539 | Chiral Pt(II)-V(V) Bimetallic Cages and Guest-Induced Allosteric Regulation of Catalytic Asymmetric Sulfoxidation. | Flexible metal-organic cages can provide confined active metal sites and show promise in mimicking metalloenzymes. In this study, we synthesized two flexible chiral bimetallic coordination cages, [(PEt<sub>3</sub>)<sub>6</sub>Pt<sub>3</sub>(<i>R</i>,<i>R</i>,<i>R</i>-<b>VL</b>)<sub>2</sub>]<sup>6+</sup> and its enantio... |
39912526 | Investigation of the Interaction of Ionic Surfactants with Epoxy-Based Hydrogels by SANS. | We investigated the effect of two ionic surfactants on the composition and structure of hydrogels obtained by swelling an epoxy amphiphilic polymer network (APN) using a combination of gravimetry and small-angle neutron scattering (SANS). Stoichiometric epoxy APN was synthesized by the reaction of diamino and diepoxy-t... |
39912405 | Exploring covalent inhibitors of SARS-CoV-2 main protease: from peptidomimetics to novel scaffolds. | Peptidomimetic inhibitors mimic natural peptide substrates, employing electrophilic warheads to covalently interact with the catalytic Cys145 of M<sup>pro</sup>. Examples include aldehydes, α-ketoamides, and aza-peptides, with discussions on their mechanisms of action, potency, and structural insights. Non-peptidomimet... |
39912334 | Immunometabolism of Liver Xenotransplantation and Prospective Solutions. | End-stage liver diseases, such as hepatocellular carcinoma or acute liver failure, critically necessitate liver transplantation. However, the shortage of available organ donors fails to meet the rapidly growing transplantation demand. Due to the high similarity of liver tissue structure and metabolism between miniature... |
39912296 | Cryogenic Organometallic Carbon-Fluoride Bond Functionalization with Broad Functional Group Tolerance. | The unique properties of fluorinated organic compounds have received intense interest and have conquered a myriad of applications in the chemical and pharmaceutical sciences. Today, an impressive range of alkyl fluorides are commercially available, and there are many practical methods to make them exist. However, the u... |
39912207 | Mixed-Matrix Membrane-Based Piezoelectric CO<sub>2</sub> Sensor with Self-Humidity Compensation. | Monitoring the CO<sub>2</sub> concentration is crucial for assessing respiratory illnesses in humans and safeguarding the environment. The ongoing difficulty lies in achieving highly sensitive detection while also eliminating the interference caused by humidity. There is an unmet need for portable sensors with both hig... |
39911126 | Binding Energy Calculations of Anthracene and Rhodamine 6G H-Type Dimers: A Comparative Study of DFT and SMD Methods. | With the ever-growing need to study systems of increased size and complexity, modern density functional theory (DFT) methods often encounter problems arising from the growing computational demands. In this work, we have presented a comprehensive DFT validation of the steered molecular dynamics (SMD) approach in estimat... |
39911055 | Anti-protozoal potential of electrospun polymeric nanofiber composite membranes for treatment of contaminated drinking water. | The effectiveness of conventional techniques for removal of water contaminants remains doubtful on micropollutants, including waterborne protozoa. To the best of knowledge, this study is the first highlighting the use of electrospun polymeric nanofiber composite membranes coated with metal nanoparticles against <i>Cycl... |
39911053 | Review of microRNA detection workflows from liquid biopsy for disease diagnostics. | MicroRNAs have emerged as effective biomarkers in disease diagnostics, particularly cancer, due to their role as regulatory sequences. More recently, microRNAs have been detected in liquid biopsies, which hold immense potential for early disease diagnostics. This review comprehensively analyses distinct liquid biopsy m... |
39911050 | Protein Stacking on the APTES-Functionalized Pyrochlore Bi<sub>2</sub>Ru<sub>2</sub>O<sub>7</sub> Clusters for Ultrasensitive and Selective Immunosensing. | With their unique physicochemical properties, such as metallic-like conductivity, favorable (electro)catalytic properties, electrochemical stability, and ease of functionalization, pyrochlores have found applications in various fields such as solid oxide fuel cells, batteries, thick film resistors, and temperature sens... |
39910583 | Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds. | Seawater-immersed wounds can be threatened by high pH, high permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for the rapid preparation of α-lipoic acid (LA)-based bioadhesives at room temperature with strong and underwater adhesion for e... |
39910569 | Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells. | Breast cancer (BC) is a significant cause of cancer-related deaths among women worldwide. Hypoxia, a common feature of solid tumor, is associated with drug resistance and a poor prognosis in BC. In this study, we present a strategy to overcome hypoxia-induced chemotherapy tolerance in BC. Specifically, we synthesized a... |
39910083 | Spatially controlled multicellular differentiation of stem cells using triple factor-releasing metal-organic framework-coated nanoline arrays. | Improved in vitro models are needed for regenerative therapy and drug screening. Here, we report on functionally aligned nanoparticle-trapped nanopattern arrays for spatially controlled, precise mesenchymal stem cell differentiation on a single substrate. The arrays comprise nanohole and nanoline arrays fabricated thro... |
39909997 | Microneedle-Based Approaches for Skin Disease Treatment. | The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints of conventional drug delivery methods by their superior safety and efficacy through precise tar... |
39909885 | Unveiling the potential of copper-61 vs. gallium-68 for SSTR PET imaging. | <h4>Purpose</h4>In recent years, copper-61 has attracted considerable attention from both physicists and radiochemists due to its favorable physical decay properties for PET imaging and its ease of production at any cyclotron center producing [<sup>18</sup>F]FDG. The aim of this study was to evaluate the potential of <... |
39895378 | Germ granule-mediated mRNA storage and translational control. | Germ cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules. These membrane-less organelles form through the condensation of RNA and proteins, governed by multivalent biomolecular interactions. RNA granules compartmentalize cell... |
39838931 | Tuning metal-support interactions in MOF-derived CoNi@NC supported Pd catalysts for efficient hydrogenation of bicarbonate using glycerol as a hydrogen donor. | The hydrogenation of bicarbonate, a byproduct of CO<sub>2</sub> captured in alkaline solutions, into formic acid (FA) using glycerol (GLY) as a hydrogen source offers a promising carbon-negative strategy for reducing CO<sub>2</sub> emissions. While Pd-based catalysts are effective in this reaction, they often require h... |
39835939 | A novel overtone peak self-referencing fluorescent sensor based on a bipyridine-linked covalent organic framework for highly sensitive copper ion detection. | This study reports a novel ratiometric fluorescence sensor based on a tetraphenylethylene-bipyridine covalent organic framework (TPE-Bpy-COF) for the sensitive detection of Cu<sup>2+</sup>, leveraging the unique coordination properties of the bipyridine moieties. The interaction between Cu<sup>2+</sup> and the nitrogen... |
39835374 | Zirconium <i>vs.</i> hafnium: a comparative study of mesoporous MOF stability. | A wide range of mesoporous Zr and Hf metal-organic frameworks (MOFs), namely MIP-206, MOF-808, and NU-1000, as well as the microporous UiO-66, were systematically investigated and compared in terms of thermal and chemical stability. The holistic effects of metal type (Zr <i>vs.</i> Hf), linker type (small and rigid <i>... |
39829319 | Comprehensive DFT investigation of small-molecule adsorption on the paradigm M-MOF-74 family of metal-organic frameworks. | The capture of toxic chemicals such as NH<sub>3</sub>, H<sub>2</sub>S, NO<sub>2</sub> and SO<sub>2</sub> is essential due to the tremendous threats they pose to human health and the environment. The M-MOF-74 family of metal-organic frameworks has recently gained attention as a promising category of sorbent materials fo... |
39821204 | Stack bonding in pentacene and its derivatives. | Understanding the nature of π-stacking interactions is important to molecular recognition, self-assembly, and organic semiconductors. The stack bond order (SBO) model of π-stacking has shown that the conformations of dimers are found at orientations where the combinations of monomer MOs are overall bonding within the s... |
39813088 | Rational design and synthesis of atomically precise nanocluster-based nanocomposites: a step towards environmental catalysis. | Atomically precise metal nanoclusters (NCs) and metal-organic frameworks (MOFs) possess distinct properties that can present challenges in certain applications. However, integrating these materials to create new composite functional materials has gained significant interest due to their unique characteristics through a... |
39718340 | Growth of the metal-organic framework ZIF-67 on cellulosic substrates for triboelectric nanogenerators. | Metal-organic frameworks (MOFs) are porous crystalline materials with a metal ion coordinated to a ligand molecule. Recently, MOFs are being explored extensively for energy harvesting <i>via</i> triboelectrification. However, the majority of MOFs are brittle and hard to grow, thus leading to poor device stability and f... |
39718125 | A promising role of noble metal NPs@MOFs in chondrosarcoma management. | Chondrosarcoma, a challenging and malignant neoplasm originating from cartilage cells, poses significant diagnostic and therapeutic hurdles due to its resistance to conventional treatments and the complexity of its diagnosis. Noble metal nanoparticle-embedded metal-organic frameworks (NPs@MOFs) stand out as a novel app... |
39704073 | Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages. | Atherosclerosis is the main pathogenic factor of various cardiovascular diseases. During the pathogenesis of atherosclerosis, macrophages play a major role, mainly by secreting pro-inflammatory cytokines and taking in lipids to form foam cells. Thiamine pyrophosphate (TPP) is an antagonist of the P2Y6 receptor, which i... |
39692272 | Film thickness dependence of nanoscale arrangement of a chiral electron donor in its blends with an achiral electron acceptor. | The nanoscale chiral arrangement in a bicomponent organic material system comprising donor and acceptor small molecules is shown to depend on the thickness of a film that is responsive to chiral light in an optoelectronic device. In this bulk heterojunction, a previously unreported chiral bis(diketopyrrolopyrrole) deri... |
39688448 | Dynamic regulation of ion transport through a bis(1,3-propanediol)-based channel <i>via</i> allosteric azobenzene photoswitching. | The transportation of ions across cell membranes is vital in biological functions and is frequently controlled by external triggers like light, ligands, and voltage. Synthetic ion transport systems, particularly those featuring gating mechanisms, have attracted considerable interest. In this research, we engineered sel... |
40814416 | Development of Nanocarrier-Based Oral Pegfilgrastim Formulations for Mitigating Hematopoietic Acute Radiation Syndrome. | The increasing risks of ionizing radiation from deep space travel and nuclear accidents necessitate the development of effective countermeasures. Acute radiation syndrome (ARS), particularly hematopoietic ARS (H-ARS), leads to life-threatening anemia and bone marrow failure, with long-term risks including cancer and ca... |
40182798 | Temporal and spatiotemporal soliton molecules in ultrafast fibre lasers. | Ultrafast fibre lasers, characterized by ultrashort pulse duration and broad spectral bandwidth, have drawn significant attention due to their vast potential across a wide range of applications, from fundamental scientific to industrial processing and beyond. As dissipative nonlinear systems, ultrafast fibre lasers not... |
40060998 | The synthesis and investigation of novel 3-benzoylbenzofurans and pyrazole derivatives for anti-HIV activity. | The emergence of drug-resistant viruses continues to be an obstacle to effectively controlling the HIV/AIDS pandemic. The development of novel drugs with high potency and the ability to fully eradicate HIV-1 infections is therefore of critical importance. Novel pyrazole derivatives were synthesized from 3-benzoylbenzof... |
40034985 | Functionalized zeolite regulates bone metabolic microenvironment. | The regulation of bone metabolic microenvironment imbalances in diseases such as osteoporosis, bone defects, infections, and tumors remains a significant challenge in orthopedics. Therefore, it has become urgent to develop biomaterials with effective bone metabolic microenvironmental regulatory functions. Zeolites, as ... |
40034544 | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma. | Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved in cancer development and development. Non-coding RNAs are abundantly enriched in exosomes, which play a biological role as vectors. Some biofunctional non-coding RNAs are specifically designed... |
40034281 | Exploration of natural products for the development of promising cholinesterase inhibitors in Alzheimer's disease treatment. | Cholinesterase enzymes (BuChE and AChE) are privileged biological targets for the symptomatic treatment of Alzheimer's disease. Indeed, inhibition of cholinesterase enzymes has been proven to improve the neurotransmission mechanisms in Alzheimer's disease patients. In this investigation, we attempt to highlight new cho... |
40032447 | Enhancement of curcumin bioaccessibility: An assessment of possible synergistic effect of γ-cyclodextrin metal-organic frameworks with micelles. | Biocompatible γ-cyclodextrin metal-organic frameworks (γ-CD-MOFs) have been reported to improve the apparent solubility and bioavailability of encapsulated bioactive compounds, including curcumin, potentially enabling sustained delivery. However, disintegration of γ-CD-MOFs may "release" encapsulated curcumin within th... |
40028145 | Molecular Glue-Design-Evaluator (MOLDE): An Advanced Method for In-Silico Molecular Glue Design. | Protein function modulation using small-molecule binding is an important therapeutic strategy for many diseases. However, many proteins remain undruggable due to the lack of suitable binding pockets for small-molecule binding. Proximity-induced protein degradation using molecular glues has recently been identified as a... |
40027547 | New approach methodologies to assess wanted and unwanted drugs-induced immunostimulation. | This review examines various classes of drugs, focusing on their therapeutic and adverse effects, particularly in relation to immunostimulation. We emphasize the potential of new approach methodologies (NAMs) to study both expected and unexpected immunostimulatory effects. By evaluating the modes of action of different... |
40027449 | Unveiling the role of the PhoP master regulator in arsenite resistance through <i>ackA</i> downregulation in <i>Lacticaseibacillus paracasei</i>. | In bacteria, the two-component system PhoPR plays an important role in regulating many genes related to phosphate uptake and metabolism. In <i>Lacticaseibacillus paracasei</i> inactivation of the response regulator PhoP results in increased resistance to arsenite [As(III)]. A comparative transcriptomic analysis reveale... |
40026620 | NIR-triggered and glucose-powered hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy. | Diabetic infections/wounds remain to be a threatening challenge as it seriously leads to lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) of diabetic in... |
40026451 | Presenting Antimicrobial Peptides on Poly(ethylene glycol): Star-Shaped vs Comb-Like Architectures. | Conjugating antimicrobial peptides (AMPs) to nonlinear polymers is a promising strategy to overcome the translational challenges of AMPs toward treating infections caused by antibiotic-resistant bacteria. Nonlinear polymers, and therefore conjugates, can be prepared with various architectures (e.g., star-shaped, comb-l... |
40018372 | Promoting π-Facial Interactions in Phenyl-Substituted 1,8-Bis(silylamido)naphthalene Alkaline Earth Complexes. | Bimetallic 1,8-bis(silylamido)naphthalene alkaline earth complexes [(<sup>R<sub>3</sub></sup> L)Ae]<sub>2</sub> ([<sup>R<sub>3</sub></sup> L]<sup>2-</sup> = [1,8-{(R<sub>3</sub>Si)N}<sub>2</sub>C<sub>10</sub>H<sub>6</sub>)]<sup>2-</sup>, where R<sub>3</sub> = Ph<sub>2</sub>Me, Ae = Ca (<b>1</b>), Sr (<b>2</b>), and Ba ... |
40017788 | Surface Modification of Polyesters Using Biosourced Soil-Release Polymers. | Soil-release polymers (SRPs) are important components of fabric care formulations, performing important roles in the cleaning of synthetic fabrics. SRPs modify the surface of textiles and render materials resistant to staining, while offering environmental benefits by enabling effective cleaning using shorter, cooler w... |
40008205 | Small Rotations, Big Effects: Lessons from Water Adsorption in NU-1000. | In this study, the adsorption mechanism of water in the metal-organic framework NU-1000 was investigated using molecular simulations. The simulations predict a significant impact of small changes in terminal aquo ligand orientation on the shape and pressure of the condensation step in the water adsorption isotherm. The... |
40006565 | Subcellular Organelle Targeting as a Novel Approach to Combat Tumor Metastasis. | Tumor metastasis, the spread of cancer cells from the primary site to distant organs, remains a formidable challenge in oncology. Central to this process is the involvement of subcellular organelles, which undergo significant functional and structural changes during metastasis. Targeting these specific organelles offer... |
40006025 | Potential of Newly Synthesized Sea Buckthorn Phytocarriers as Anti-Inflammatory Active Agents. | <b>Background:</b> Phytocarriers are advanced drug delivery systems that use biocompatible and biodegradable materials to enhance the efficacy, stability, and bioavailability of natural products. The sea buckthorn (<i>Hippophae rhamnoides</i> L.) berry extract is rich in essential fatty acids and antioxidants, includin... |
40006027 | <i>Phaseolus acutifolius</i> Recombinant Lectin Exerts Differential Proapoptotic Activity on EGFR<sup>+</sup> and EGFR<sup>-</sup> Colon Cancer Cells and Provokes T Cell-Assisted Antitumor Responses in Mice. | <b>Background:</b><i>r</i>TBL-1, a recombinant lectin from <i>Phaseolus acutifolius</i>, exhibit proapoptotic activity on colon cancer cells and inhibitory properties on colon tumorigenesis in vivo. Apoptosis has been associated with a phospho-EGFR/phospho-p38/phospho-p53 mechanistic axis. Immunogenicity data have been... |
40005711 | Sulfide-Responsive Transcription Control in <i>Escherichia coli</i>. | To elucidate the mechanism of large-scale transcriptional changes dependent on sulfide in <i>Escherichia coli</i>, a large-scale RNA-sequencing analysis was performed on wild-type and sulfide-responsive transcription factor YgaV deletion mutants grown under three conditions: aerobic, semi-aerobic, and semi-aerobic with... |
40002778 | Looking to the Future of Viral Vectors in Ocular Gene Therapy: Clinical Review. | Eye diseases can significantly affect the quality of life of patients due to decreased visual acuity. Although modern ophthalmological diagnostic methods exist, some diseases of the visual system are asymptomatic in the early stages. Most patients seek advice from an ophthalmologist as a result of rapidly progressive m... |
39998087 | Brown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications. | Accidents caused by <i>Loxosceles</i> spiders, commonly known as brown spiders, are frequent in warm and temperate regions worldwide, with a higher prevalence in South America and the southern United States. In the venoms of species clinically associated with accidents, phospholipases D (PLDs) are the most expressed to... |
39996655 | Chiral Supramolecular Hydrogels Regulating Both Osteoblastogenesis and Osteoclastogenesis. | Osteoporosis, a chronic bone disorder, poses a global threat to the health of millions of individuals. The disruption of bone homeostasis is the fundamental cause of osteoporosis. Currently, clinical drugs are employed to promote bone formation via enhancing osteogenesis and/or reduce bone loss via inhibiting osteoclas... |
39989829 | Lignin Ultrafiltration Fractionation and Self-Assembly to Monodisperse Nanoparticles for Photonic Materials. | Lignin, a natural aromatic polymer, is a promising candidate for sustainable photonic materials. However, its heterogeneity hinders uniform nanoparticle production. This study employs membrane ultrafiltration to fractionate alkaline lignin into five molecular weight fractions (UL1-UL5) and synthesizes lignin nanopartic... |
39989811 | Detection of an Intermediate in the Unfolding Process of the N-Terminal Domain of TDP-43. | TAR DNA-binding protein 43 (TDP-43) is a nuclear protein accumulating in intraneuronal cytoplasmic inclusions associated with amyotrophic lateral sclerosis, frontotemporal lobar degeneration with tau-negative/ubiquitin-positive inclusions, and limbic-predominant age-related TDP-43 encephalopathy. Oligomerization of ful... |
39989756 | Electrochemical Determination of Dipyrone Using a Cold-Plasma-Treated Graphite Sheet Electrode. | The development of fast, reliable, and cost-effective techniques for pharmaceutical compound analysis is an issue of paramount importance to the pharmaceutical industry, environmental sciences, and many other applications. In this work, a low-cost graphite sheet electrode (GSE) was used as a disposable working electrod... |
39981136 | A functional SNP of the core promoter region within goat C<i>DC25A</i> gene affects litter size. | The <i>Cell division cycle 25A</i> (<i>CDC25A</i>) gene has been considered as a candidate gene associated with reproductive traits for goat breeding. In this study, five truncated fragments divided at position-2285 nt to +198 nt were amplified and cloned into the luciferase reporter vectors to identify the core promot... |
39975683 | Case report: The value of early application of mNGS technology in the diagnosis and treatment of severe Legionnaires' disease: reports of two cases with different outcomes. | <h4>Background</h4>Legionnaires' disease has a high clinical mortality rate, and early diagnosis and treatment are critical. Increasing evidence shows that metagenomic next-generation sequencing (mNGS) has excellent potential for the early identification of pathogens. To help clinicians better recognize Legionnaires' d... |
39975598 | Photodynamic therapy for the precise treatment of localized prostate cancer. | Over the past 20 years, early diagnosis of prostate cancer has become increasingly prevalent due to the promotion of prostate-specific antigens, and its treatment has become a focal point. However, there are some drawbacks associated with therapies for early prostate cancer, such as active surveillance and radical pros... |
39974733 | Discovering broad-spectrum inhibitors for SARS-CoV-2 variants: a cheminformatics and biophysical approach targeting the main protease. | The COVID-19 pandemic caused by SARS-CoV-2 still lacks effective antiviral drugs. Therefore, a thorough receptor-based virtual screening study was conducted to screen different natural and synthetic drug libraries, such as the Asinex Antiviral, Seaweed Metabolite Database, Medicinal Fungi Secondary Metabolite and Thera... |
39974155 | Establishment of an indirect ELISA method for detecting bovine coronavirus antibodies based on N protein. | Bovine Coronavirus (BCoV) is a significant pathogen responsible for neonatal calf diarrhea, winter dysentery in adult cattle, and bovine respiratory diseases. Infection with the virus can result in hemorrhagic diarrhea, decreased milk production, and potentially fatal outcomes in cattle, leading to considerable economi... |
39973930 | Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China. | <h4>Introduction</h4>As a re-emerging mosquito-borne virus, Getah virus (GETV) has been found in more than 10 countries surrounded by the Pacific Ocean and shows a broadly host tropism, raising concerns for the potential risk to public health. Horses and pigs are susceptible to GETV and play pivotal roles to the GETV a... |
39973929 | Biochemical characterization of the <i>Escherichia coli</i> surfaceome: a focus on type I fimbriae and flagella. | The <i>Escherichia coli</i> surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large polymeric surface organelles are composed of hundreds to thousands of subunit... |
39973925 | The functions of herpesvirus shuttling proteins in the virus lifecycle. | During viral infection, the transport of various proteins between the nucleus and cytoplasm plays an important role in the viral lifecycle. Shuttling proteins are key factors in the transmission of nucleocytoplasmic information within cells and usually contain nuclear localization signals and nuclear export signals to ... |
39959298 | Determination of Dissociation Constants for the Interaction of Myosin-5a with its Cargo Protein Using Microscale Thermophoresis (MST). | Myosin-5a (Myo5a) is an actin-dependent molecular motor that recognizes a diverse range of cargo proteins through its tail domain, playing a crucial role in the transport and localization of various organelles within the cell. We have identified a new interaction between Myo5a and its cargo protein melanophilin (Mlph),... |
39958643 | Novel supramolecular artificial light-harvesting systems based on AIE-active macrocycles for efficient white-light photocatalysis in water. | Constructing supramolecular artificial light-harvesting systems (ALHSs) based on the Förster resonance energy transfer (FRET) mechanism provides an optimal platform for understanding natural photosynthesis and simulating natural light-harvesting systems. In the present work, rigid macrocycle K-1 with a nonplanar confor... |
39950065 | Noble-metal-free catalysts for the oxygen evolution reaction in acids. | Oxygen evolution catalysts are critical components of proton exchange membrane water electrolysers (PEMWEs), playing a decisive role in determining both the performance and cost of these devices. Non-noble metal-based oxygen evolution catalysts have recently drawn significant attention as potential alternatives to expe... |
39942827 | Clicked H-Shaped Arylopeptoids. | This study presents a tentative synthesis of supported H-shaped and ladder-type compounds. If the ladders were not accessible, probably due to distance misfits between the reactive centers, a facile method for the synthesis of H-shaped <i>N</i>-alkylated aminomethyl oligobenzamides, i.e., arylopeptoids by on-resin homo... |
39942818 | Silk Sericin-Based Electrospun Nanofibers Forming Films for Cosmetic Applications: Preparation, Characterization, and Efficacy Evaluation. | This study investigates the extraction, characterization, and cosmetic application of silk sericin, a protein derived from <i>Bombyx mori</i> silkworm cocoons, with a focus on its potential in sustainable and biodegradable cosmetic formulations. Sericin was extracted using a high-temperature, high-pressure autoclave de... |
39942821 | Research Progress in the Construction Strategy and Application of Superhydrophobic Wood. | Wood serves as a green biomass material with sustainable utilization and environmental friendliness. The modification of wood can be used to obtain superhydrophobic properties and further expand wood's application range. This paper focuses on the development status of superhydrophobic surfaces with micro-/nanoscale rou... |
39942820 | Sam-Sam Association Between EphA2 and SASH1: In Silico Studies of Cancer-Linked Mutations. | Recently, SASH1 has emerged as a novel protein interactor of a few Eph tyrosine kinase receptors like EphA2. These interactions involve the first N-terminal Sam (sterile alpha motif) domain of SASH1 (SASH1-Sam1) and the Sam domain of Eph receptors. Currently, the functional meaning of the SASH1-Sam1/EphA2-Sam complex i... |
39942813 | Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat. | This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and Piemontese). Neu5Gc, a non-human sialic acid linked to inflammation and ... |
39942798 | Mechanism of Action and Therapeutic Potential of Xanthohumol in Prevention of Selected Neurodegenerative Diseases. | Xanthohumol (XN), a bioactive plant flavonoid, is an antioxidant, and as such, it exhibits numerous beneficial properties, including anti-inflammatory, antimicrobial, and antioxidative effects. The main dietary source of XN is beer, where it is introduced through hops. Although the concentration of XN in beer is low, t... |
39942105 | Formation Mechanisms of Protein Coronas on Food-Related Nanoparticles: Their Impact on Digestive System and Bioactive Compound Delivery. | The rapid development of nanotechnology provides new approaches to manufacturing food-related nanoparticles in various food industries, including food formulation, functional foods, food packaging, and food quality control. Once ingested, nanoparticles will immediately adsorb proteins in the biological fluids, forming ... |
39941124 | Structural Characteristics and Properties of the RNA-Binding Protein hnRNPK at Multiple Physical States. | Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein containing low-complexity domains (LCDs), which are known to regulate protein behavior under stress conditions. This study demonstrates the ability to control hnRNPK's transitions into four distinct material states-monomer, soluble aggregate, ... |
39941111 | Predicting Antibody Affinity Changes upon Mutation Based on Unbound Protein Structures. | Antibodies are key proteins in the immune system that can reversibly and non-covalently bind specifically to their corresponding antigens, forming antigen-antibody complexes. They play a crucial role in recognizing foreign or self-antigens during the adaptive immune response. Monoclonal antibodies have emerged as a pro... |
39940219 | Nanoimprinted Materials for Nanoparticle Sensing and Removal. | The booming expansion of nanotechnology poses the problem of environmental pollution by nanoparticles (NPs). The available methods for sensing and removing NPs from the environment are typically lengthy and instrumentally demanding. The recent introduction of NP-imprinted polymers (NPIPs), either as films or bulk mater... |
39937014 | The Importance of Monitoring Antigen-Specific Memory B Cells, and How ImmunoSpot Assays Are Suitable for This Task. | Determining an individual's humoral immune reactivity to a pathogen, autoantigen, or environmental agent is traditionally accomplished through the assessment of specific antibody levels in blood. However, in many instances, titers of specific antibodies decline over time and thus do not faithfully reveal prior antigen ... |
39937013 | Update of Aging Hallmarks in Idiopathic Pulmonary Fibrosis. | Idiopathic Pulmonary Fibrosis (IPF) is an epithelial-driven interstitial lung disease of unknown etiology characterized by the excessive proliferation of fibroblast populations that synthesize large amounts of extracellular matrix. In this devastating disorder, all aging hallmarks appear prematurely or are altered. Thi... |
39936122 | Deep co-deposition of polydopamine in PVDF hydrogel to enhance photothermal evaporation efficiency. | Polydopamine (PDA) is a widely utilized photothermal conversion material recognized for its ease of synthesis and environmental friendliness. However, its relatively weak light absorption capabilities lead to lower photothermal efficiency, restricting its application in solar steam generation (STG) processes. To effect... |
39935502 | Synergistic engineering of ultraviolet metal-free crystals with exceptional birefringence <i>via</i> pyridine-derived dimers. | Crystals with giant birefringence are essential for practical applications in lasers, optical communication, and polarimetry, where precise control of polarized light is critical. Coplanar six-membered ring (6-MR) primitives with large polarizability anisotropy are particularly effective in enhancing birefringence. Thi... |
39933486 | Multi-component driven fluorescence composite nanospheres coating strategy: Spectral properties, release, tumor imaging and bioactivity evaluation in a simulated gastrointestinal microenvironment. | Carborane has been widely studied for its excellent tumor-targeting and other properties, but its poor water solubility and inability to visualize the treatment limit the application of carborane. Therefore, in this paper, two different indol-nido-carbrane potassium salt-crown ether-sodium alginate polymers were obtain... |
39931533 | Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease. | Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. Currently, therapies a... |
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