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41915413 | Synthesis, structure, and magnetic properties of Fe<sup>3+</sup> and Ru<sup>3+</sup> metal chalcogenide (O,S) complexes with bidentate ligands. | Hydroxypyridinones represent a versatile class of bidentate ligands for the construction of coordination compounds with tuneable structural and magnetic properties. In this work, we systematically investigate the coordination chemistry and magnetic behaviour of two group VIII trivalent transition metals (Fe<sup>3+</sup... |
41915253 | Machine learning-guided rational engineering of ACE2-derived peptides for broad-spectrum neutralization of SARS-CoV-2 variants. | The dynamic mutational landscape of SARS-CoV-2, especially within the spike glycoprotein's RBD, continues to undermine the effectiveness of available therapeutics. Although ACE2-derived peptides have previously been explored as spike inhibitors, their rational optimization has largely lacked systematic, data-driven sel... |
41915036 | Plasmon Mode-Selective Gold Nanodimers with a Metal-Semiconductor Hybrid Junction. | Plasmonic dimers are versatile platforms for manipulating light-matter interactions at the nanoscale, supporting hybridized modes such as capacitive plasmons (CPs) and charge transfer plasmons (CTPs), which are highly sensitive to the nature of the interparticle junction. However, these junctions have largely been rest... |
41914983 | Exosome-niosome hybrid oxygen carrier for protection against acetaminophen-induced acute liver injury. | Acetaminophen (APAP) overdose is one of the contributing factors for acute liver injury (ALI), caused by a hypoxic microenvironment, elevated oxidative stress, and pro-inflammatory signaling. In this work, we present an exosome-niosome hybrid oxygen carrier (ENh-OC) composed of polysorbate 80, Pluronic® F-127, medium c... |
41914884 | Circular Dichroism Reveals Positive Cooperativity through Compensatory Motion in Stepwise Cage Metalation. | Biological allosteric systems achieve functional control through long-range communication between distant binding sites. Here, we report that a symmetric chiral cage bearing two equivalent tris(2-pyridylmethyl)amine (<b>TPMA</b>) binding sites exhibits structural communication reminiscent of allosteric behavior during ... |
41914852 | Chirality-Induced Spin Selectivity in an Achiral Electron Donor-Acceptor Molecule Doped into a Cholesteric Liquid Crystal. | Chirality-induced spin selectivity (CISS) enables control over radical pair spin dynamics for applications in quantum information science (QIS). In this study, we show that this control can be achieved through supramolecular chirality transfer, rather than relying on the intrinsic molecular chirality of the molecule us... |
41914758 | Roles of the cGAS-STING signaling pathway in viral latency. | Viral latency is a sophisticated survival strategy that allows the viral genome to persist indefinitely while remaining invisible to immune surveillance. This stealth impedes eradication, and episodic reactivation compounds the hurdle, necessitating therapeutic innovation. Recently, increasing evidence has indicated th... |
41914753 | Cross-neutralization and antigenic characterization of simian and equine group A rotaviruses. | Rotaviral diarrhea in foals is caused by two dominant G3P[12] and G14P[12] genotypes of equine rotavirus A (ERVA). Protection of foals against ERVA infection and disease is achievable by passive antibody transfer through colostrum from mares receiving inactivated monovalent G3P[12] vaccine. Simian rotavirus SA11 G3P[2]... |
41914607 | Tailoring the Charge and pH Responsiveness of Nanoparticles by Combining LCST Smart Polymers and Polyelectrolytes on Surfaces. | The modification of nanoparticles with combinations of low critical solution temperature (LCST) polymers and polyelectrolyte (PE) layers was studied. Three <i>n</i>-isopropylacrylamide-<i>co</i>-acrylamide polymers were synthesized, in which the charges could be varied from neutral to negative or positive by incorporat... |
41914568 | Self-Powered Ultraviolet Photodetectors Based on In Situ Growth Position-Controllable ZnO@Zn<sub>3</sub>(HHTP)<sub>2</sub> Core-Shell Arrays. | Conjugated conductive metal-organic frameworks (MOFs) have garnered widespread attention in the field of optoelectronics due to their excellent electrical conductivity and unique porous structures. Currently, the interaction between MOF materials and semiconductors predominantly relies on van der Waals forces, which we... |
41914369 | A Biomimetic Nanomachine Reprograms Transmembrane ATP Flux to Induce Tumor-Selective Bioenergetic Crisis. | Cancer cells maintain malignancy via dysregulated adenosine triphosphate (ATP) synthesis and efflux, yet conventional ATP-depleting therapies remain limited by transient efficacy and compensatory resistance. Here, we present a materials-driven strategy for "transmembrane ATP flux reprogramming" that actively exploits e... |
41914341 | A Triple-Acceptor Motif for Chalcogen-Bond-Directed Circular Assemblies that Enhance Singlet Oxygen Generation. | Herein, we report a triple-acceptor donor-acceptor (D-A) molecule designed with three consecutively linked acceptors to confer substantial conformational flexibility. This conformational flexibility translates into distinct crystalline packing modes, which yield strikingly different photosensitizing efficiencies. Notab... |
41913688 | Deep Molecular Bowls with Four Pentagons. | The study of deep molecular bowls featuring high curvature and tailored properties remains rare. In this work, we report a series of buckybowls that incorporate pyrrole-type and cyclopentadienyl-type pentagons. X-ray crystallographic analyses confirmed their significantly deepened bowl depths and high curvatures. Their... |
41913616 | [Research on the modification of poly(amido amine) with poly peptides to induce enamel remineralization]. | <b>Objective:</b> To develop SN15-PAMAM by grafting the statherin-derived peptide SN15 onto a PAMAM dendrimer for enhanced tooth adsorption and remineralization, and to evaluate its efficacy in promoting the remineralization of demineralized enamel in a simulated oral environment. <b>Methods:</b> (1) SN15 peptides were... |
41912951 | Fusion protein based strategies for developing insect-resistant crops. | Insect pest control in crop production incurs substantial economic costs annually on a global scale. Although broad-spectrum chemical pesticides were once considered the most effective solution, their overreliance has led to adverse effects on beneficial insects, human health, and the environment, as well as the develo... |
41841167 | Charged ligand-driven photoluminescence sensing enhancements in terbium-modified two-dimensional metal-organic frameworks. | Charged ligands and terbium ions are post-synthetically coordinated in a two-dimensional, dispersible, and water-stable zirconium-based metal-organic framework (MOF). MOF molecular sheets with positively charged and negatively charged ligands provide distinct electrostatic interactions to ionic analytes, thereby enhanc... |
41834756 | Scalable metal-organic frameworks for efficient low concentration CO<sub>2</sub> capture under humid flue gas conditions. | The global energy supply still largely relies on fossil fuels, whose combustion releases significant amounts of carbon dioxide (CO<sub>2</sub>), the primary anthropogenic greenhouse gas linked to climate change. Adsorption on solid porous materials offers a promising alternative to conventional amine-based systems for ... |
41834662 | Transition metal complexes with phosphine oxide appended aza-macrocycles - effects of ring size and denticity. | Two new phosphine oxide appended aza-macrocyclic ligands, L1 and L3, have been prepared in good yield from the reaction of Bn-tacn and Bn-cyclen (tacn = 1,4,7-triazacyclononane; cyclen = 1,4,7,10-tetraazacyclododecane) with paraformaldehyde and diphenylphosphine oxide. They are characterised spectroscopically and <i>vi... |
41817349 | Noncovalent interactions for enhancing organic electronic device function. | Organic electronic device performance is increasingly recognized as an emergent property governed by molecular organization. This review highlights how noncovalent interactions enable precise control over molecular packing and nanoscale morphology in organic semiconductors. The key concept is the structure-function rel... |
41782523 | MOF-reinforced NIR-responsive composite hydrogel with photothermal antibacterial and antioxidant activities for diabetic wound healing. | Chronic diabetic wounds are marked by recurrent infection, persistent ROS and prolonged inflammation. Herein, we report a MOF-reinforced NIR-responsive composite hydrogel (CEPN) that features a dual-cross-linked network assembled from carboxymethyl chitosan (CMCS), polydopamine (PDA), epigallocatechin gallate (EGCG) an... |
41744178 | DNA-based hybrid nanoparticles: from design to application in cancer therapy. | Deoxyribonucleic acid (DNA)-based hybrid nanoparticles represent a cutting-edge class of advanced nanomaterials engineered by integrating functional inorganic or organic components with programmable DNA scaffolds. These hybrid systems synergistically combine the unique optical, magnetic, and thermal properties of funct... |
41734171 | Structural features and antibacterial activity of Ni(II) thiosemicarbazones in a zirconium metal-organic framework composite. | Metal-Organic Frameworks for Biological Applications (BioMOFs) are materials that incorporate therapeutically active ligands into the framework that offer an alternative strategy which combines the structural advantages of MOFs with enhanced functionality for pharmacological properties. The tunable interactions between... |
42006734 | Recent advances in self-assembled nanoplatforms for central nervous system disorders therapy: Design principles, multifunctional strategies, and therapeutic applications. | The incidence of central nervous system (CNS) disorders is increasing worldwide, while the development of CNS drugs remains extremely challenging due to high costs, long development cycles, and high failure rates. The CNS is highly protected by physiological barriers, particularly the blood-brain barrier (BBB) and the ... |
42006651 | Optimization of fumed silica and melatonin loadings in polyvinyl alcohol-based films for postharvest preservation of rambutan fruit. | To address high hydrophilicity of polyvinyl alcohol (PVA) and agglomeration tendency of fumed silica (FS), melatonin (MT)-functionalized PVA/FS composite films were prepared to enhance their performance and applicability. MT (1-3%) mitigated FS aggregation and promoted interfacial adhesion, forming a denser network. Th... |
42004736 | Enhanced Piezoelectric Effect in P(VDF-TrFE) through Synergistic Templating by PEDOT:PSS and Paper. | To reduce the harm of electronic waste, there is impetus to expand the use of biodegradable substrates, biocompatible materials, and battery-free devices. In this study, a piezoelectric paper composite is produced by integrating polyvinylidene fluoride-trifluoroethylene [P-(VDF-TrFE)] with the conducting polymer poly-(... |
42004038 | A bacteriophage-encoded protein gp119 suppresses deoxyinosine repair to protect hypermutated viral genome. | Bacteriophage <i>Fletcherviruses</i> completely replace deoxyguanosine (dG) with deoxyinosine (dI) in their genomes. Through a genetic screen of 172 open reading frames from <i>Fletchervirus</i> NCTC 12673, we identified gp119, an ArdA-like protein that inhibits dI repair and enhances the efficiency of A-to-G conversio... |
42004034 | Current trends, applications, and challenges in three-dimensional bioprinting for cardiovascular disease models and therapies. | Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. Although conventional treatments such as surgery and transplantation have improved patient survival, they are subject to major limitations. Three-dimensional (3D) bioprinting presents new opportunities for treating CVDs, with the long-term obje... |
41993885 | Exploring the Regulatory Function of NGAL in MMP-9 Complexes. | Matrix metalloproteinase 9 (MMP-9) is an enzyme involved in the degradation of the extracellular matrix and in numerous physiological and pathological processes. One of the less understood regulatory mechanisms of MMP-9 is its interaction with neutrophil gelatinase-associated lipocalin (NGAL), leading to the formation ... |
41993631 | Sensitization strategy for sonodynamic therapy. | Sonodynamic therapy (SDT), a tumor treatment modality characterized by deep tissue penetration and high spatiotemporal precision, faces multiple challenges in clinical translation, including suboptimal sonosensitizer efficiency, suppression by the tumor microenvironment (TME), and insufficient induction of antitumor im... |
41983129 | Ferroptosis: unveiling a transformative perspective in the landscape of autoimmune diseases. | Ferroptosis, fundamentally defined as an iron-catalyzed and lipid peroxidation-driven cell death process, constitutes an underlying disease mechanism in autoimmune pathogenesis. Recent studies demonstrate that ferroptosis not only shapes innate and adaptive immune responses-including T and B lymphocytes, macrophages, n... |
41983137 | Poly(I:C) and R848 adjuvants elicit sizeable humoral immunity to liver stage malaria antigens. | <h4>Background and objectives</h4><i>Plasmodium falciparum</i> infection remains a major global health burden due to increasing drug resistance and lack of an effective vaccine. Targeting the exoerythrocytic liver stage (LS) of malaria infection offers a promising approach to achieve sterile immunity to malaria infecti... |
41983124 | Advances in research on the mechanisms of anti-inflammation of silybin: a review. | Silybin, as the main active component of milk thistle, has attracted significant attention in recent medical research due to its remarkable anti-inflammatory effect. Inflammatory responses are an important mechanism in the pathogenesis of various clinical diseases, and controlling inflammation is crucial for the preven... |
41982717 | <i>N</i>‑Myristoyltransferase Inhibitors as a Potential Starting Point for the Development of Antischistosomal Agents. | Schistosomiasis remains a major global health challenge, and the threat of emerging praziquantel resistance highlights the need for new therapeutic strategies. Here, the <i>Schistosoma mansoni N</i>-myristoyltransferase was evaluated as a potential drug target. Six reported NMT inhibitors were tested for <i>Sm</i>NMT i... |
41982521 | Reducing ammonia emissions and nitrate leaching in wheat-maize systems by substituting chemical fertilizers with manure. | <h4>Introduction</h4>Ammonia (NH<sub>3</sub>) emissions and nitrate (NO<sub>3</sub> <sup>-</sup>) leaching from crop fields are major contributors to non-point source environmental pollution.<h4>Methods</h4>To optimize the resource utilization of pig manure and reduce gaseous and liquid nitrogen losses in wheat-maize r... |
41982466 | <i>In vitro</i> evaluation of CD40-targeting aptamer-based DNA vaccine adjuvants using HD11 cell culture. | <i>Salmonella</i> is a major foodborne pathogen that colonizes the gastrointestinal tract of poultry, compromising bird health and productivity while posing significant public health threats. Consumption of contaminated poultry products is the leading cause of <i>Salmonella</i>-related illnesses in humans. Although num... |
41982460 | Bioinformatics based design of thermostable virus-like particles-based vaccine for foot-and-mouth disease serotype A and <i>in-vivo</i> evaluation in guinea pigs. | <h4>Background</h4>Foot-and-mouth disease (FMD) is a contagious disease affecting cloven footed animals. Existing vaccines although effective, has limitations of short immunity, needs cold chain maintenance, high biosafety levels facilities for production and inability to differentiate infected from vaccinated animals.... |
41982240 | ESRP2 constrains EMT plasticity associated with ZEB1 expression in bladder cancer. | <h4>Introduction</h4>Epithelial-to-mesenchymal transition (EMT)-driven phenotypic plasticity promotes bladder cancer (BC) progression and therapy resistance. While EMT has been primarily associated with transcriptional reprogramming, the contribution of post-transcriptional mechanisms, particularly alternative splicing... |
41977591 | Application of Composite Raman Probes in Tumor Diagnosis and Imaging. | Raman spectroscopy offers unique molecular fingerprinting capability for cancer diagnosis and monitoring, yet its biomedical application is fundamentally limited by weak intrinsic signals and complex biological backgrounds. Composite Raman probes, particularly surface-enhanced Raman scattering (SERS)-based systems, ove... |
41977337 | Pharmacological Management of Thrombosis: Current State and Future Strategies. | Thromboembolic disorders remain a primary cause of mortality globally, with their burden expected to increase due to an aging population. While various antithrombotic agents exist, many patients still rely on traditional gold-standard drugs like heparin, warfarin, and aspirin, which present significant drawbacks. These... |
41977304 | Bone Organoids as Advanced Models for Osteoporosis: Development, Application, and Future Prospects. | The prevalence of osteoporosis, a skeletal disorder characterized by reduced bone mass, microarchitectural deterioration, and increased fracture risk, poses a substantial global healthcare burden. Although animal models and two-dimensional cell cultures have been used to advance bone research, they do not completely re... |
41977311 | Network Pharmacology-Guided Identification of <i>Candida albicans</i> Secondary Metabolites as Modulators of HIV Latency via Oncogenic Signaling Pathways. | HIV latency, driven by a complex interplay of host factors, remains a key barrier to viral clearance. Current latency-reversing agents (LRAs) demonstrate limited efficacy and specificity, and none have been approved for clinical use. Although natural products have shown promise as LRAs, the therapeutic potential of fun... |
41977325 | A Comparative Review of Artificial Intelligence Applications in Small Molecule Versus Peptide Drug Discovery. | Traditional drug discovery processes are typically expensive, time-consuming, and have a very high failure rate. Artificial intelligence (AI) is currently reshaping this field in unprecedented ways, promising to significantly improve the efficiency and success rate of drug development. This article systematically compa... |
41977306 | New Multicomponent Crystals of Antidiabetic Drug, Metformin: Mechanochemistry, Structural Studies, Biological Activity and Topological Analysis. | Three multicomponent crystals of metformin were investigated to elucidate factors governing crystal architecture. Structures were determined by X-ray diffraction and analyzed using the Atoms-in-Molecules (AIM) approach, focusing on critical points and electron density topology. Three types of crystals were obtained: sa... |
41976660 | Defect-Engineered La-Mn Co-Doped β-PbO<sub>2</sub> Anodes for Energy-Efficient Zinc Electrowinning. | The high energy consumption of lead anodes in zinc production is caused by the slow oxygen evolution reaction (OER). We made a La-Mn co-doped β-PbO<sub>2</sub> anode using electrodeposition to solve this issue. The XRD and XPS results show that adding La shrinks the lattice and changes the electron structure. This help... |
41976456 | Crosslinked-AuNPs@CD-MOF Incorporated into PLA-Zein Composite Film with Humidity-Responsive Antimicrobial Release for <i>Agaricus bisporus</i> Preservation. | Foodborne pathogens cause hundreds of millions of illnesses annually, underscoring the urgent need for advanced antimicrobial food packaging materials. The objective of this study was to develop a crosslinked cyclodextrin metal-organic framework, loaded with gold nanoparticles (CL-AuNPs@CD-MOF) and integrated into a PL... |
41976184 | Silk Fibroin for Biomedical Applications with Emphasis on Bioimaging, Biosensing and Regenerative Systems: A Review. | Biomaterials are engineered to interact with biological systems for therapeutic or diagnostic purposes. Among them, natural biomaterials offer important advantages over many synthetic polymers, including intrinsic biocompatibility, non-toxicity and biodegradability. Silk fibroin, a fibrous protein derived mainly from <... |
41976179 | Advances in Natural Product Extraction: Established and Emerging Technologies. | Natural product research has experienced substantial growth over the past two decades, driven by a renewed appreciation for the structural complexity and biological relevance of compounds derived from nature. Technological advances in separation science, spectroscopic characterization, and high-sensitivity bioassays ha... |
41972709 | Novel Perspectives on the Relationship Between the Gastrointestinal Mucus Barrier and Soybean Agglutinin. | The gastrointestinal mucus barrier (GIMB) is a gelatinous structure consisting primarily of mucins, water, and cathelicidin. Such a structure is the first line of defense against pathogens in the intestinal cavity and acts an important environment for the survival and reproduction of symbiotic flora. Mucin is mainly sy... |
41972557 | Sex-Specific Thermal Adaptation in <i>Riptortus pedestris</i>: Integrating Logistic Thresholds and Transcriptomic Responses. | The bean bug <i>Riptortus pedestris</i> (Hemiptera: Alydidae) is a major soybean pest in Asia, increasingly threatened by rising temperatures. It is crucial to clarify the high-temperature lethal thresholds of <i>R. pedestris</i> for predicting population dynamics under climate warming. Previous physiological data show... |
41970861 | Development and <i>In Silico</i>/<i>In Vivo</i> Evaluation of a <i>Pogostemon cablin</i> Essential Oil Cream as a Repellent against <i>Aedes aegypti</i>. | Mosquito-borne diseases remain a major global public health concern, and the development of safer botanical repellents represents an important complementary strategy to synthetic products. In this study, the essential oil of <i>Pogostemon cablin</i> (PCEO) was chemically characterized and incorporated into a topical cr... |
41966023 | Network pharmacology-guided self-assembling quercetin hydrogel from Astragalus membranaceous accelerates diabetic wound healing. | <h4>Background</h4>Delayed diabetic wound healing remains a significant clinical challenge. Astragalus membranaceus, a traditional Chinese herb, is widely used for the topical treatment of diabetic wounds. However, its complex composition has hampered the identification of its main active components and precise mechani... |
41946076 | Effects of drinking water valerian extract and stocking density on stress, performance, and egg quality in laying Japanese quails. | The objective of this study was to evaluate the effects of Valerian (Valeriana officinalis L.) extract added to drinking water on productive performance, egg quality, and stress indicators in laying quails (Coturnix japonica) under different stocking densities, with emphasis on their interaction with valerian supplemen... |
41940179 | Application of Trichoscopy and Novel Non-Invasive Imaging Techniques in the Diagnosis and Management of Patients with Scalp Psoriasis. | Scalp psoriasis affects up to 80% of patients with psoriasis and possesses a significant challenge as a difficult-to-treat area. A comprehensive literature search was conducted in PubMed using relevant keywords to identify recent studies focusing on scalp psoriasis diagnosis and treatment. The diagnosis is mainly based... |
41939211 | Natural Polymers Based Biocompatible Nanomedicines for Targeting Colon Cancer: Prospects and Challenges. | Natural polymers have gained significant attention as materials for the development of biocompatible nanomedicines, offering promising potential for the targeted treatment of colon cancer. These biopolymers are derived out of renewable resources and possess many beneficial characteristics such as biodegradability, low ... |
41939208 | Nanohydrogels for Diabetic Wound Healing: Mechanisms, Applications, and Future Perspectives. | Diabetic wound healing remains a significant clinical challenge, characterized by persistent hyperglycemia, chronic inflammation, impaired angiogenesis, and recurrent infections. Traditional wound dressings often fail to address the complex pathological microenvironment of diabetic wounds. Nanohydrogels, particularly n... |
41939209 | Engineering the Future: Strategic Advances in Extracellular Vesicle-Mediated Drug Delivery Systems. | Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles naturally secreted by cells that inherently lack replicative capacity and function as endogenous carriers of biological cargo including proteins, nucleic acids, and metabolites for intercellular communication. Leveraging their intrinsic biocompatibil... |
41939207 | Liposomal Delivery Systems for Improved Delivery of Docetaxel Against Prostate Cancer. | Generally, liposomes as a delivery system have been vastly designed for the delivery of therapeutic agents, to overcome various drawbacks, including resistance imposed to various conventional forms of these agents. They are significantly advantageous compared to other kinds of delivery systems because of their ability ... |
41937525 | Nanoparticle-Based Therapeutics for Breast Cancer: Advances, Challenges, and Clinical Perspectives. | <h4>Introduction</h4>Breast cancer (BC) is the most frequently recognized fatal carcinoma, accounting for the majority of deaths among women worldwide. Approximately 2.3 million women worldwide are affected by BC each year, and the disease causes about 670,000 deaths. Molecular heterogeneity, frequent intrinsic/acquire... |
41936253 | An overview of hydrogel-modified electrodes for electrochemical biosensing. | As an innovative sensing platform, electrochemical biosensors have been extensively developed in academic research for diverse applications: clinical diagnostics, food safety, environmental monitoring, pharmaceutical analysis, etc. These devices convey molecular recognition events to prompt and readable electrical sign... |
41936106 | Integrative Nanotechnology and Biomaterial Approaches for Targeted Diabetic Wound Regeneration. | Recent advancements in drug delivery technologies, bioactive molecules, and biomaterial design have transformed the therapeutic landscape of diabetic wound management. Diabetic wounds remain a major clinical challenge due to persistent inflammation, impaired angiogenesis, and reduced tissue regeneration, primarily caus... |
41934787 | Construction of anti-HER2 conjugated injectable hydrogel via protein crosslinking and gadolinium-tetraaza coordination for multimodal tumor theranostics. | The development of targeted, multifunctional protein hydrogel systems offers a safe and robust platform for advancing precision cancer theranostics. Here, we construct an anti-HER2 mediated injectable hydrogel by self-assembling bovine serum albumin within a tetraaza-macrocycle scaffold, integrating crosslinking and an... |
41933550 | Rational MOF carrier engineering for tunable ATP detection. | Adenosine triphosphate (ATP) serves as a critical biomarker in clinical diagnosis and microbial quantification. Given the substantial variation in ATP levels among biological samples, developing assays with high sensitivity and a tunable linear range is essential for ensuring broad method applicability. In this work, w... |
41932297 | Redox-responsive drug delivery nanoparticles with integrated capabilities of ROS scavenging, lipid removal and anti-inflammation. | Atherosclerosis, a leading cause of cardiovascular morbidity and mortality, is characterized by elevated reactive oxygen species (ROS), lipid accumulation, and chronic inflammation in plaques. Targeted drug delivery using nanotechnology represents a promising therapeutic strategy aligned with these pathological feature... |
41932242 | Molecular filling and metal ion-mediated DNA self-assembly strategy enable evaluation of lung cancer metastasis. | Accurately assessing the risk of lung cancer metastasis is crucial for improving patient prognosis and quality of life. In this study, we developed a rapid, homogeneous fluorescence detection system (DNA-N@Ag<sup>+</sup>@PIX) for lung cancer mesenchymal circulating tumor cells (M-CTCs) based on a molecular filling stra... |
41932197 | Molecular encapsulation of hydroxychloroquine by cucurbit[n]urils: A combined molecular dynamics simulation and quantum chemical study. | The inclusion complexation of hydroxychloroquine (HCQ), a biologically active pharmaceutical compound, with three cucurbit[n]urils, CB[6], CB[7], and CB[8], was investigated using a combination of molecular dynamics simulations and quantum chemical calculations. The results indicate that HCQ can be accommodated within ... |
41930337 | Antibody-Drug Conjugates in Oncology: Principles, Clinical Development, and Future Directions. | Antibody-drug conjugates (ADCs) have emerged as a major therapeutic modality in oncology, enabling the targeted delivery of highly potent cytotoxic agents while expanding the therapeutic window in solid tumors. Recent clinical successes across breast, lung, and genitourinary cancers have highlighted that ADC efficacy i... |
41921883 | Nanocarrier-based drug delivery strategies for Raynaud's phenomenon: Overcoming microvascular and perfusion barriers. | Raynaud's phenomenon (RP) is a functional vascular disorder characterized by episodic vasospasm of the digital microcirculation, resulting in transient ischemia, sensory disturbances, and pain. Despite long-standing clinical recognition, effective pharmacological management of RP remains challenging due to perfusion-li... |
41921803 | A dual-functional thermo-responsive hydrogel based on magnesium-Gallate MOFs for enhanced bone regeneration and angiogenesis. | The treatment of critical-size bone defect, particularly those with irregular shapes, presents a significant clinical challenge. Chitosan hydrogels, owing to their degradability, excellent biocompatibility and injectability, represent a promising carrier platform for bone tissue engineering (BTE). Bioavailable Mg<sup>2... |
41921442 | Fabrication of porous phenylboronic acid/cyclodextrin modified covalent triazine frameworks for selective extraction of salbutamol from pork samples. | A porous boronate affinity adsorbent was synthesized by anchoring β-cyclodextrin (β-CD) and 3-aminomethylphenylboronic acid (AMPBA) onto perfluorinated covalent triazine framework (FCTF). This fabricated FCTF@β-CD@AMPBA exhibited pronounced selectivity toward cis-diol containing targets and notable uptake of salbutamol... |
41919274 | A Hemoglobin-Based Nanoparticle Delivery System Enhances the Pharmacokinetics and Efficacy of Tigecycline in <i>Klebsiella pneumoniae</i> Infections. | <b>Objective:</b> This study aims to engineer a tigecycline-hemoglobin nanoparticle (TIG-HBNP) system to enhance the targeting effect of tigecycline (TIG) on <i>Klebsiella pneumoniae</i>, thereby improving its antibacterial efficacy. <b>Impact Statement:</b> This study represents the first report of loading TIG onto he... |
41919203 | Tailoring charge transport in perovskite photovoltaics <i>via</i> chalcogen-thiophene molecular bridges. | We present in this research the theoretical design and development of a Lewis base molecule, <i>n</i>-Bu4S, formed of fused thiophene units bridged by tetra-pyridine, as a versatile interfacial passivation layer for perovskite solar cells (PSCs). Strong host-guest interactions between <i>n</i>-Bu4S and under-coordinate... |
41919208 | Synergistic SA/Pebax composite membranes on ceramic supports for efficient ethanol-water separation. | Efficient ethanol-water separation is vital for sustainable biofuel production, yet conventional techniques remain energy-intensive. This work presents synergistic sodium alginate (SA)/Pebax composite membranes supported on ceramic tubes for high-performance pervaporation. By tuning SA/Pebax ratios (5 : 1 to 3 : 2) and... |
41919215 | Selective Functionalization of 1-substituted-3-arylquinoxalin-2(1<i>H</i>)-ones <i>via</i> C-H activation. | Over the past few decades, transition-metal-catalyzed selective functionalization of C-H bonds has fascinated the scientific community by offering striking advantages in comparison to traditional methods, such as high atom economy, a reduced number of reaction steps, and milder reaction conditions. Moreover, directing-... |
41919205 | Innovation in microbial bioactive materials: electrospun ectoine/ε-PL/PVA fiber dressing as a bioactive and hemocompatible material with potential for wound healing applications. | Bioactive fibers are innovative natural therapeutics, which are capable of mimicking the body's biological environment to accelerate healing, fight infections, and revolutionize regenerative medicine with extraordinary precision and effectiveness. In this study, we produced ectoine and epsilon-poly-l-lysine using <i>Ha... |
41919214 | Fluorescence-enhanced BINOL-hybridized ladder-type siloxanes and their sensing of Fe<sup>3</sup>. | In this study, we synthesized two novel vinyl-substituted, BINOL-hybridized tricyclic-ladder-type siloxanes (referred to as Vi-TLS-BINOLs) <i>via</i> a B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-catalyzed Piers-Rubinsztajn reaction. Fluorescence studies of the Vi-TLS-BINOLs revealed enhanced fluorescence emission attrib... |
41919219 | Rapid and facile colorimetric biosensing of dengue NS1 antigen using gold nanoparticles: potential for point-of-care testing. | Dengue fever is one of the major global health concerns with increasing incidence and mortality. Early and accurate detection is essential to prevent severe outcomes, especially in resource-limited facilities. Here, we report a rapid, low-cost colorimetric biosensor based on gold nanoparticles (AuNPs) synthesized using... |
41919199 | Nearest neighbour interactions between amino acid residues in short peptides and coil libraries. | Intrinsically disordered proteins (IDP) or proteins with intrinsically disordered regions (IDR) perform a plethora of functions mostly in a cellular environment. As unfolded proteins, IDPs can adopt molten globule or coil ensembles of conformations. Regarding the latter, the question arises as to whether they are descr... |
41919200 | Structural studies, thermochromic luminescent properties and crystal-to-crystal transformation of a double-stranded Cu<sup>I</sup>-I-bisquinoline coordination polymer. | The development of thermochromic luminescent materials with reversible chemical transformation capabilities based on earth-abundant metals is a central topic in materials chemistry. While several stimuli-responsive materials have been reported, compounds that respond to physical stimuli and can undergo single-crystal-t... |
41918934 | MDCrow: automating molecular dynamics workflows with large language models. | Molecular dynamics (MD) simulations are essential for understanding biomolecular systems but remain challenging to automate. Recent advances in large language models (LLMs) have demonstrated success in automating complex scientific tasks using LLM-based agents. In this paper, we introduce MDCrow, an agentic LLM assista... |
41916295 | Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds. | Persistent inflammation derived from neutrophil activation drives delayed healing of diabetic wounds. Herein, a dissolvable alginate methacryloyl-based microneedle patch functionalized with polypeptide CFLFLFK-NH<sub>2</sub>-coupled manganese/zinc ion metal-organic framework (MnZn-MOF) loading enalaprilat (Ena) (TMZE@A... |
41913531 | Cerium-Based Mixed-Metallic Organic Frameworks: Recent Advances in Syntheses and Applications. | This review presents recent progress and advances in cerium-based mixed-metallic organic frameworks (MMOFs), focusing on their synthesis, structural features, and diverse applications. The unique redox behavior of the Ce(III)/Ce(IV) couple, superior oxygen absorption potential, and strong coordination with carboxylate ... |
41913518 | Interfacial Chirality Transfer Induced by Vortices inside Microdroplets. | Chiral materials have broad applications in optics. Precise regulation of the chiral signal, however, remains highly challenging. Herein, a microfluidic strategy is proposed in which the cooperative action of dual driving forces regulates vortical flow inside droplets. The flow rate and interfacial tension are adjusted... |
41913508 | Cooperative Spin Alignment Enhances Selective Singlet Oxygen Generation in Wastewater Pre-Oxidation System. | Selective nonradical oxidation to enhance biodegradability is an attractive route for wastewater pretreatment, but molecular control of peroxymonosulfate (PMS) activation remains elusive. Here we report a Fe-N<sub>4</sub> catalyst with second-shell boron coordination (FeN<sub>4</sub>/B) synthesized by supramolecular se... |
41913465 | Bottlebrush Side Chain Isomers: Spherical Self-Assembly Eliminates PEG Crystallinity at Room Temperature. | Bottlebrush block copolymer (BBCP) self-assembly provides opportunities to create a range of nanostructures exceeding the domain sizes traditionally found in linear copolymer systems. The same architecture that provides them with their unique self-assembly, however, makes exploring their structure-property relationship... |
41913430 | Temporal Flux Organization as a Principle for Network-Controlled Self-Assembly. | ConspectusSelf-assembly is a central paradigm in chemistry, enabling complex molecular architectures to emerge from simple components. Traditionally, self-assembly processes have been classified as thermodynamically controlled─yielding the most stable product at equilibrium─or kinetically controlled, where outcomes are... |
41913271 | Zinc-coordination-driven mitochondrial nanodisruptors to ablate cancer stemness for potentiating immunotherapy in colorectal malignancies. | Cancer stemness, sustained by mitochondrial metabolic plasticity, drives immunotherapy resistance in colorectal cancer (CRC). We reengineer zeolitic imidazolate framework-8 (ZIF-8), a zinc-coordination-driven metal-organic framework, from inert nanocarrier to a multifunctional mitochondrial synchronizer that disrupts s... |
41913262 | Identification of oviposition attractants for Peridroma saucia based on characterization of the female antennal-predominant odorant-binding protein PsauOBP6. | <h4>Background</h4>The variegated cutworm Peridroma saucia has recently emerged as a polyphagous pest causing substantial crop damage in the Huang-Huai River Basin in China. Oviposition attractants are promising tools for developing behavior-based pest management strategies. Functional characterization of female antenn... |
41913072 | Pyrrole-Bearing Porous Network Polymers Synthesized via Halogen-Bond-Assisted Radical Solid-Phase Polymerization for Highly Efficient and Selective Adsorption of Lithium Ions from Model Seawater Reverse Osmosis (SWRO) Brine. | Methylene pyrrole oligomers (MPOs) with multiple vinyl groups and a calix[4]pyrrole (CP) macrocycle with multiple vinyl groups were synthesized and used as monomers in halogen-bond (XB)-assisted radical solid-phase polymerization (SPP) to generate network polymers. The monomers were cocrystallized with additional XB li... |
41912798 | Differentiation of sphingomyelin and cholesterol by hyperspectral mid-infrared detection of single-bond vibrational modes in the fingerprint region. | Lipids play a central role in a multitude of biological functions associated with cancer, obesity, diabetes, cardiovascular and neurological pathologies. However, sensing and mapping of lipid classes in living cells remains challenging. Here we introduce a label-free approach to lipid imaging, which differentiates lipi... |
41912782 | Supramolecular assembly of molecular wires alternating crown ethers and metal-halide complexes. | Metal-halide complexes serve as key emissive centres in halide perovskites; however, precise control over their spatial organization through bottom-up assembly is challenging. Here we show that a crown-ether-assisted supramolecular assembly strategy can alternatingly connect metal-halide complexes and (crown ether@A)<s... |
41912731 | P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors. | Although chronic stress is known to trigger neuroinflammation and depressive-like behaviors, the mechanisms linking stress sensors to inflammatory cascades remain elusive. The purinergic receptor P2X7 (P2X7R), an extracellular ATP-gated cation channel primarily expressed in microglia, is a critical link between stress ... |
41912649 | Elucidating the relationship between affinity and potency in the performance of therapeutic IgE. | IgE antibodies exert strong immunostimulatory effects and their anti-tumour effectiveness is currently being assessed in clinical trials. The high affinity of IgE for FcεRI may result in the binding of exogenously delivered antibody to effector cells prior to antigen engagement, potentially leading to IgE being present... |
41912562 | Interchain supramolecular interactions drive nearly 21% efficiency organic solar cells. | A small-molecule acceptor, S-Cb, substituted with a cyclobutyl group that introduces high ring strain, was designed and synthesized. Thanks to the rigid and planar structure of cyclobutyl, S-Cb can form interchain supramolecular interactions through hydrogen bonding with L8-BO at the external side chains. This clamping... |
41912547 | Domain gain or loss in a fungal chitinase enables specialization towards antagonism or immune suppression. | Effector proteins orchestrate interactions that determine host compatibility and microbial competition. Among these are microbial chitinases, widespread enzymes involved in nutrient acquisition, fungal cell-wall remodelling, and antagonism, yet how their functions diversify across ecological roles remains unclear. Here... |
41911693 | BiVO<sub>4</sub>@Ce-BDC-NH<sub>2</sub>nanocomposite based on VO<sub>4</sub>vacancy and heterostructures for electrochemical detection of Metol. | We develop a highly active electrocatalyst composite based on BiVO<sub>4</sub>@Ce-BDC-NH<sub>2</sub>(B(VO)<sub>1-δ</sub>@CeBN) nanocomposite including VO<sub>4</sub>vacancies ((VO)<sub>1-δ</sub>) and heterojunction comprising bismuth vanadate (BiVO<sub>4</sub>) and a cerium-based metal-organic framework (Ce-BDC-NH<sub>... |
41911551 | Transient Interactions of α-Synuclein N- and C-Termini. | α-Synuclein (αSyn) is a neuronal protein predominantly found at the synapse, involved in vesicle trafficking. αSyn aggregates are also the main component of Lewy bodies, the hallmarks of Parkinson's disease. Interactions between the N- and C-termini of αSyn play crucial roles in its behavior in solution, membrane bindi... |
41911480 | Organic Crystal-MXene Composites as Temperature-Tolerant Strain Sensors. | Flexible organic crystals offer significant opportunities for organic electronics; however, their potential applications in fields like flexible sensors are at present limited by poor charge transport that result in failure under reversible conditions. In this report, we propose a universal interfacing design strategy ... |
41911471 | Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation. | Proteolysis-targeting chimeras (PROTACs) are becoming a powerful therapeutic strategy, enabling event-driven elimination of disease-causing proteins. While small-molecule PROTACs have advanced rapidly, their broader application is constrained by limited target scope, dependence on druggable binding pockets, and suscept... |
41911463 | Co-opting the bacterial lipoprotein pathway for the biosynthesis of lipidated macrocyclic peptides. | Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are structurally diverse natural products that possess a range of bioactivities, often acting as antibiotics, antifungals, or metallophores. In RiPP biosynthesis, different modifying enzymes install an array of chemical motifs onto a precursor pe... |
41911305 | Varying the Interparticle Distances of Gold Nanospheres and Nanorods via Polymer Ligand Chain Lengths. | The surface modification and functionalization of nanoparticles with polymer ligands is the focus of current research in order to improve nanoparticle stability and to control nanoparticle assembly. The surface attachment of end-functionalized polymers is a versatile route to structurally well-defined stabilizing polym... |
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