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41911253 | Assessment of miRNAs as transcriptional regulators in respiratory syncytial virus infection through computational analysis and molecular docking studies. | Globally, RSV is a major contributor to severe lower respiratory tract infections among children. Despite the significant medical concern posed by RSV, efforts to develop effective vaccines and antiviral drugs have largely fallen short, with the exception of immune prophylaxis available only for specific high-risk infa... |
41911170 | Axially Nitrogen-Doped Cycloparaphenylenes with Conformationally Adaptive Dihydrophenazine Units. | We report the design and synthesis of a series of dihydrophenazine-embedded macrocycles as axially nitrogen-doped cycloparaphenylenes (CPPs). The conformational flexibility of the dihydrophenazine units favors the formation of highly strained three-membered macrocycles whose pronounced bending leads to distinct photoph... |
41911072 | A Programmable Plug-and-Play Sensing Platform for Ultrasensitive Detection via Adaptive Supramolecular Assembly. | The development of a versatile and programmable sensing platform is crucial for advancing intelligent diagnostics and environmental monitoring. Herein, we present a plug-and-play, polypeptoid-based sensing platform capable of rapid and accurate detection of multiple analytes, exemplified by dipicolinic acid (DPA) and t... |
41911060 | A Wearable Supramolecular Fingertip Sensor for Colorimetric Detection of Food-Derived Tyramine. | Wearable sensing technologies are emerging as promising tools for rapid on-site screening and process monitoring, owing to their direct and user-friendly human-device interfaces. However, achieving rapid, selective, and visually interpretable early warning detection in wearable formats remains challenging. Here, we pro... |
41910953 | Engineering Cooperative Microenvironments in a Nitro-Functionalized Trinuclear Copper Metal-Organic Framework for High-Efficiency Heterogeneous Catalysis. | The deliberate engineering of cooperative catalytic microenvironments within metal-organic frameworks (MOFs) offers a powerful strategy for promoting sustainable catalysis. Herein, we report a robust nitro-functionalized trinuclear metal-organic framework, formulated as {[Cu<sub>3</sub>(NTCB)<sub>2</sub>(4,4'-bip)(DMF)... |
41910834 | In silico and in vitro study for the limonoid isolated from Swietenia macrophylla as potential α-glucosidase inhibitor. | Limonoids are important constituents of Swietenia macrophylla, exhibiting a range of biological activities that influence human health. Swietenia macrophylla, a well-known medicinal plant, is particularly rich in limonoids, which have been reported to exhibit significant therapeutic potential. Given the increasing inte... |
41910807 | Hydrogen-bonded complexes of glycyl-l-glutamate with nucleosides: a dft and qtaim study. | <h4>Context</h4>The complex formation between peptides and nucleosides underlies the molecular recognition and regulation processes in biological systems. The present study focuses on the optimized structures of complexes formed between the glycyl-L-glutamate and four nucleosides-adenosine, guanosine, cytidine, and uri... |
41910805 | Effect of carboxymethyl substitution position on urea interaction with carboxymethyl chitosan: a density functional theory study. | <h4>Context</h4>Among natural polymers, chitosan has gained considerable attention due to its excellent hemocompatibility and ability to enhance urea transport. Modifying chitosan into carboxymethyl chitosan (CMCs) enhances the number of active sites for hydrogen bonding, leading to greater selectivity toward urea mole... |
41910746 | Regenerative bone-targeted nanoparticles modulate osteoclast function. | Osteoclasts are vital for maintaining bone health. Indeed, dysregulated osteoclast activity is linked to pathological conditions such as Paget's disease, osteoporosis, and impaired fracture healing. Despite their importance in bone regeneration, few biomaterial-based strategies have been developed to alter osteoclast r... |
41910676 | Toward non-enzymatic glucose sensing based on organic electronics: organic field-effect transistors with multifunctionalized extended-gate electrodes. | Accurate glucose analysis has been a major research focus for the past five decades since the pioneering development of enzymatic glucose sensing, driven by the global demand for rapid and reliable diagnostics. In contrast to well-established enzymatic glucose sensors, the development of chemical sensors based on supra... |
41910622 | Electronic structure dictates performance: why Mg-MOF-74 outperforms its peers in direct air capture of CO₂. | <h4>Context</h4>The urgent need for scalable direct air capture (DAC) technologies is hindered by the lack of adsorbents that efficiently capture CO₂ from ambient air. While metal-organic frameworks (MOFs) such as the M-MOF-74 series show promise, a systematic electronic-level comparison of their DAC suitability is lac... |
41910615 | Thioketal-Based Polymers for Biomedical Applications: Structure Design, Properties, And Perspectives. | Reactive oxygen species (ROS) are highly enriched in pathological microenvironments such as inflammation, tumors, and ischemia-reperfusion, providing an endogenous trigger for on-demand drug release, degradation, and clearance. The thioketal (TK) moiety is stable under normal physiological conditions but undergoes oxid... |
41910581 | Reprogramming Chirality in Peptide Self-Assembly via Intramolecular Side Chain-Backbone Hydrogen Bonding. | While main chain-main chain and side chain-side chain interactions are known to maintain protein architectures, the role of main chain-side chain interactions remains largely unexplored. Among various amino acid side chains, uncharged polar ones may uniquely modulate molecular conformations through directional hydrogen... |
41910405 | Disruption of spike protein N-glycosylation induces its endoplasmic reticulum retention and attenuates SARS-CoV-2 infectivity. | The spike (S) protein of SARS-CoV-2 is extensively glycosylated, with N-glycosylation sites remaining highly conserved during viral evolution. While inhibiting N-glycosylation has been shown to significantly suppress SARS-CoV-2 infection, the underlying molecular mechanisms remain incompletely characterized. Here, we i... |
41910386 | β-Sheet Polyelectrolyte Nanostructures: Design, Self-Assembly, In Vitro, and In Vivo Biological Activity. | Engineering macromolecular systems having protein-like intelligence is a challenging task since synthetic strategies required to impart both α-helical and β-sheet secondary structures in high molecular weight polypeptides along with polyelectrolyte characteristics in a single system. α-Helical polypetide polyelectrolyt... |
41910389 | Energy-Screened Many-Body Expansion for Protein-Ligand Interactions: Examining Convergence for Metalloenzymes Through Seven-Body Interactions. | Fragment-based quantum chemistry is a powerful strategy for calculating protein-ligand interaction energies using quantum chemistry methods. Rigorous convergence often requires hundreds of atoms in the protein binding-site model, especially if that model is constructed using distance-based criteria to select amino acid... |
41910268 | Decapod iridescent virus 1 (DIV1) enters hematopoietic <i>Cherax quadricarinatus</i> cells via caveola-mediated endocytosis in a pH-dependent manner. | Decapod iridescent virus 1 (DIV1), the first isolated species of the genus <i>Decapodiridovirus</i> (family <i>Iridoviridae</i>), is a major pathogen threatening farmed decapods, causing large-scale disease outbreaks and high mortality. However, the mechanisms underlying its cellular entry remain poorly understood. In ... |
41910269 | Characterization of patient-derived HPV16 E6 and E7 variant alleles. | Human papillomavirus type 16 (HPV16) is the most prevalent carcinogenic HPV type. Many HPV16 sequence variants have been described, some of which cause protein-coding mutations. However, most experiments have characterized the viral proteins encoded by the HPV16 prototype clone, and some researchers have proposed that ... |
41910257 | Gel Metal-Organic Frameworks in Highly Concentrated Electrolyte Promote Stable Solid-Electrolyte Interface on Lithium Metal Anodes. | Highly concentrated electrolytes (HCEs) have been shown to hinder dendrite formation and improve cyclability in Li-based batteries. Herein, we developed a novel strategy to use an electrolyte matrix composed of gel metal-organic frameworks (g-MOFs) and an HCE consisting of 4.5 M lithium bis(trifluoromethanesulfonyl)imi... |
41910201 | Crystallization-Driven Quadrant-Specific Spherulitic Self-Assembly in Partially Miscible Biodegradable PBS/PCL/PBS-<i>ran</i>-PCL Blends. | The inherent immiscibility of biodegradable aliphatic polyesters, such as poly(butylene succinate) (PBS) and poly(ε-caprolactone) (PCL), hampers the development of strong yet degradable plastics. Here, we demonstrate that random isodimorphic copolyesters, poly(butylene succinate-<i>ran</i>-ε-caprolactone) (BS<sub><i>x<... |
41907023 | Liquid Interfacial SERS Analyzer with Built-In Self-Reporting on Carborane-Tailored Self-Assembled Nano-Buoy Arrays. | The spontaneous assembly of nanoparticles at liquid-liquid interfaces (LLIs) to form uniform and defect-free SERS substrates has garnered considerable attention in analytical sensing. However, the soft nature of these interfaces imposes stringent requirements on LLI structural design, necessitating both interfacial sta... |
41906984 | Synergistic Buried Interface Engineering via Bisphosphonate-Anchored Co-Self-Assembled Monolayers for High-Performance Inverted Perovskite Solar Cells. | Self-assembled monolayers (SAMs) have emerged as promising materials for interface engineering in invert perovskite solar cells (PSCs). Nevertheless, conventional SAM architectures struggle to simultaneously achieve uniform molecular anchoring and effective defect passivation. To overcome this limitation, we developed ... |
41906977 | Coenzyme-Mediated Enantioselective Carboligation via Cross-β Amyloid Microphases. | Stereoselective carbon-carbon (C-C) bond formation is a fundamental transformation in metabolism, enabling the generation of chiral molecules essential for life's chemical complexity. While modern enzymes achieve such transformations with the help of cofactor-bound active sites realized via folding of large peptide cha... |
41906949 | Greatly Enhanced the Electrical Conductivity of Flexible Cu-MOF Thin Film via the Interaction with Redox-Active Guest Molecules. | Conductive metal-organic frameworks (MOFs) are of considerable importance because of their potential applications in various electronics. And integrating conductive MOFs with flexible substrates represents a promising strategy for preparing different flexible electronic devices. This study first developed a flexible an... |
41906933 | Bifunctional Peptide Amphiphile Hydrogel Orchestrates Concerted Antioxidant and Anti-Inflammatory Actions to Counter Myocardial Ischemia/Reperfusion Injury. | Myocardial ischaemia/reperfusion injury presents significant clinical challenges driven by a self-perpetuating cycle of oxidative stress and inflammation. Current therapeutic strategies fail to simultaneously address these interconnected pathological events. Here, we present T&A-Gel, a supramolecular peptide amphiphile... |
41906916 | Organoboron Cycloarenes: Boron-Carbon Annulated Macrocyclic π-Systems. | Organic macrocycles, especially cycloarenes, are important for aromaticity theory, synthetic chemistry, and material science. However, organoboron macrocycles are highly challenging, due to low stability and inefficient cyclization reactions caused by the boron atom. In this study, we disclose boron-carbon-based annula... |
41906736 | Metal Organic Framework-Derived Multivariate Flower-Like Cu-Co<sub>3</sub>O<sub>4</sub>/CoOOH Nanozymes for Designing Colorimetric Biosensing Metallothioneins. | Metallothioneins (MTs) have become important biomarkers for the early clinical diagnosis of malignancies. However, the development of a cost-effective and convenient method for the rapid monitoring of MTs still remains a substantial challenge. Herein, we propose a metal-organic framework (MOF)-derived multivariate flow... |
41778966 | A paper-based immunoassay with signal amplification for the sensitive detection of nucleocapsid protein toward the diagnosis of long COVID. | Long COVID is characterized by persistent symptoms, including fatigue, cognitive impairment, and respiratory issues, affecting a considerable number of individuals post-infection. The underlying mechanism is not fully understood, but it has been proposed to involve the reactivation of virus, which subsequently induces ... |
42005348 | Development of an injectable thermosensitive hydrogel depot system for controlled and sustained subcutaneous drug delivery. | Arthritis conditions are widely treated with oral nonsteroidal anti-inflammatory drugs, yet long-term therapy is often limited by gastrointestinal toxicity and variable systemic exposure. To overcome these issues, an injectable thermosensitive chitosan/β-cyclodextrin-<i>graft</i>-poly(N-isopropylacrylamide) hydrogel wa... |
41977584 | Effect of Inorganic Salts on Synthesis of Poly(glycidyl methacrylate) Microspheres, Their Functionalization with Poly(ethyleneimine) and Evaluation of Its Use for Removal of Acid Red 27, Acetaminophen and Nitrites. | Poly(glycidyl methacrylate) (PGMA) is a polymer containing epoxy groups in its side chains, which makes it a suitable platform for the development of functional materials. In this study, crosslinked PGMA-based microspheres were synthesized by suspension polymerization using N,N'-methylenebisacrylamide as a crosslinker,... |
41977294 | Whole-Genome Sequencing of Multidrug-Resistant <i>Acinetobacter baumannii</i> Local Isolate and Molecular Dynamics Simulation Studies of a Modified KR-12 Analog Targeting AbaQ and BfmR. | <i>Acinetobacter baumannii</i> (<i>A. baumannii</i>) represents a major threat because of its multidrug resistance, achieved through its ability to control virulence, and its mechanisms of drug efflux resistance. In this study, we used a combined experimental-computational approach to create and evaluate antimicrobial ... |
41976169 | Heteroditopic Bis-Urea and Bis-Thiourea Receptors on Merrifield and Wang Resins: Solid-Phase Synthesis and Ion-Pair Recognition. | A library of twelve heteroditopic bis-urea and bis-thiourea receptors supported on Merrifield and Wang resins was prepared by solid-phase synthesis. The receptors incorporate dual hydrogen-bond-donor units for anion binding and a polyether spacer that simultaneously functions as a cation-binding site, enabling ion-pair... |
41970863 | Density-Functional Theory Shows 2<i>H</i>‑Tetraphenylporphyrin Prefers Physisorption over Chemical Bonding on Ag(111). | Conformational changes upon adsorption can significantly influence a molecule's behavior at surfaces. In this study, we employ density functional theory (DFT) with the r<sup>2</sup>SCAN+rVV10 functional to investigate the adsorption characteristics of 2<i>H</i>-tetraphenylporphyrin (2<i>H</i>-TPP) on a Ag(111) surface.... |
41970842 | Chelator Conjugation Chemistry Matters: Squaramide Linker Enhances Tumor Contrast in <sup>68</sup>Ga-labeled Anti-CEA Nanobody Tracer. | Complexation of radiometals by chelators allows for convenient radiolabeling of molecules of interest for the preparation of radiopharmaceuticals. In the chelator family, triazacyclononane (TACN)-based macrocycles have been used ubiquitously over the last 40 years, and many bifunctional derivatives have been developed.... |
41935480 | Host-guest assisted carbon quantum dots/WS<sub>2</sub> photoelectrochemical solution-gated graphene field-effect transistor for diquat detection. | An innovative photoelectrochemical solution-gated graphene transistor (PEC-SGGT) was developed in this work for the sensitive detection of diquat (DQ). In this system, DQ acts as a molecular bridge that directs the pre-formation of a DQ@carbon quantum dots (DQ@CQDs) complex in solution and subsequently guides its assem... |
41934822 | Osteoimmune-regulative metal-organic framework nanomedicine for effective osteoporosis therapeutics. | Osteoporosis is a global degenerative bone disorder in the elderly caused by the aging of bone and immune systems. Current therapeutics for osteoporosis focus on medical control over the osteoblast and osteoclast, resulting in complicated procedures and side effects. Regulation of osteoimmunity is of high significance ... |
41932084 | Colorimetric Chemosensors for selective detection of arsenite and arsenate: DFT studies and application in water samples. | The study focuses on developing colorimetric chemosensors that selectively detects arsenite (AsO<sub>2</sub><sup>-</sup>) and arsenate (AsO<sub>4</sub><sup>3-</sup>) anions. Three furan-based colorimetric chemosensors, NCV1, NCV2 and NCV3 were synthesized and the compounds were characterized using FT-IR, <sup>1</sup>H ... |
41916499 | Nanotechnology in Cardiology: A New Era of Targeted Therapies and Advanced Diagnostics-A Review. | Heart diseases together with circulatory diseases known as cardiovascular diseases maintain their position as the world's leading cause of mortality because these disorders killed about 33% of people during 2021. Medical progress and diagnostic innovation have not addressed the major obstacles within current therapeuti... |
41916514 | Newly customized cationic ẞ-cyclodextrins as potential nanovectors for gene delivery. | Gene therapy represents a promising strategy for the treatment of severe diseases through delivery of genetic material into target cells. Its clinical translation, however, remains limited by the need for safe and efficient vectors. β-Cyclodextrins (β-CDs), owing to their biocompatibility and structural tunability, rep... |
41906626 | Converting Self-Trapped Exciton from Dark to Bright State via Excessive Eu Incorporation in CsEuCl<sub>3</sub> Nanocrystals. | CsEuCl<sub>3</sub> nanocrystals (NCs) are novel lead-free rare-earth perovskite NCs with low toxicity and intrinsic optical activity, exhibiting potential as promising alternatives to lead halide perovskites. However, the limited understanding of their dual-photoluminescence (PL) emission mechanism impedes further mate... |
41906478 | Design and Synthesis of a High-Performance Copper(II) Metal-Organic Framework Featuring Large Surface Area and Enhanced Methane Adsorption Capacity from a Thiophene-Functionalized Diisophthalic Acid Ligand. | In this study, a new copper-based metal-organic framework, {[Cu<sub>3</sub>(μ<sub>8</sub>-mtif)<sub>1.5</sub>(DMF)<sub>3</sub>]·10H<sub>2</sub>O·4DMF}<sub><i>n</i></sub> (<b>OGU-3</b>), was synthesized using 5,5'-(3-methylthiophene-2,5-diyl)diisophthalic acid (H<sub>4</sub>mtif) as an organic linker through a solvother... |
41906399 | Enlarging Quantum Coherence of Vanadyl Spin Qubits in Zirconium Porphyrinic MOFs. | The intrinsic quantum-mechanical properties of electron spin along with the structural and chemical tunability of metal-organic frameworks (MOFs) that can control the position of the active spin carrier make molecular spin qubits embedded in porous coordination frameworks an ideal platform for investigating quantum coh... |
41906326 | In Situ Insights into Enhanced Cooperative Ligand Exchange Kinetics via Solvent-Induced Restacking in a 2D Metal-Organic Framework. | Understanding the reaction kinetics at catalytically active sites is crucial for integrating catalytic two-dimensional (2D) materials into industrial processes. This study focuses on <i>in situ</i> observation of ligand exchange kinetics and solvent-assisted structural restacking transition in the 2D paddle wheel-based... |
41906311 | Identification of KLHL12 Ligands Using Fragment-Based Methods. | Targeted protein degradation can be induced by recruiting a protein of interest to an E3 ligase, resulting in its ubiquitination and subsequent proteasome-mediated degradation. However, only a small number of E3 ligases have been utilized for degradation. Expansion of the repertoire of useful E3 ligases via the identif... |
41906303 | Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease. | Genetic mutations in the leucine-rich repeat kinase 2 (LRRK2) protein have been linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder for which treatments are limited. Herein, we describe the invention of a macrocyclic LRRK2 inhibitor lead chemical series. Rigorous application of kn... |
41906286 | Investigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine. | The development of safer opioid therapeutics remains an urgent challenge, given the limitations and adverse effects of current μ-opioid receptor (MOR) agonists. Natural products such as mitragynine, the predominant alkaloid from <i>Mitragyna speciosa</i> (kratom), provide structurally complex scaffolds for probing MOR ... |
41906280 | Graphene-Oxide-Based Interfacial GO-Polymer Assemblies Stabilize Pickering Emulsions for 3D-Printed Multifunctional Cryogels. | Graphene oxide (GO)-based interfacial assemblies offer exceptional mechanical and functional properties, yet scalable fabrication of freestanding films and their integration into complex architectures remain challenging. Here, we demonstrate the fabrication of large-area, freestanding polystyrene (PS)/GO interfacial na... |
41905971 | Sustainable dye removal from industrial wastewater using marine algae-derived biosorbents and MOF-based hybrid composites. | This study presents a comparative investigation of marine algal biomasses (fresh and dried) and a zirconium-based metal-organic framework (UiO-66-NH₂) for the removal of reactive dyes from industrial wastewater. Three widely used textile dyes Reactive Yellow 2 (RY2), Reactive Red 195 (RR195), and Reactive Blue 19 (RB19... |
41904779 | Lu<sub>2</sub>CrMnO<sub>6</sub>-Pm-g-C<sub>3</sub>N<sub>4</sub> supported dendritic nanosilica as a recyclable green catalyst for eco-friendly synthesis of N-[(2-hydroxyethoxy)carbonyl] glycine from carbon dioxide. | The rational design of heterogeneous catalysts with hierarchical nanostructures and large surface areas is crucial for enhancing active site accessibility and improving catalytic efficiency. In this context, we report the synthesis of a novel, recyclable nanocatalyst composed of Lu₂CrMnO₆ nanoparticles anchored onto py... |
41904358 | Engineered exosomes for targeted glioma therapy: overcoming the blood-brain barrier with nature-inspired nanocarriers. | Gliomas mainly glioblastoma multiforme (GBM) are the greatest lethal primary brain tumors, marked by rapid progression, high heterogeneity, and poor therapeutic outcomes. A main challenge in treating gliomas lies in the limited permeability of the blood-brain barrier (BBB), which restricts drug access to the tumor site... |
42006721 | Natural carrier-free self-assembled binary polyphenol nanoparticles remodel the gut microenvironment for inflammatory bowel disease prevention. | Developing biocompatible, multi-target therapeutics remains a critical challenge in the management of inflammatory bowel disease (IBD). Herein, we engineered a carrier-free nanoplatform (Cur-Ant NPs) via the facile self-assembly of two natural polyphenols: curcumin (Cur) and anthocyanin (Ant). Spectroscopic analysis an... |
41997681 | A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3. | <h4>Background</h4>Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences ... |
41978134 | Firmicutes/Bacteroidetes Ratio as an Insufficient Indicator of Metabolic Status in Mexican Young Adults. | <b>Background:</b> The Firmicutes/Bacteroidetes (F/B) ratio has been proposed as a microbial biomarker of obesity and metabolic alterations; however, its reliability remains controversial, particularly in young populations. <b>Methods:</b> This study evaluated the relationship between the F/B ratio, body fat percentage... |
41977273 | Ion-Pair Mediated Valence Isomerization of Selected Cyclic C<sub>7</sub>H<sub>8</sub> Molecules Trapped in Insertion Complexes. | Highly polar M-mol-X (M = alkali metal, mol = molecule, X = halogen) insertion complexes have been predicted to offer potential practical applications, including molecular interactions with light, ion-pair induced isomerization, etc. In the present work, the insertion complexes of the seven-membered, fused bicyclic nor... |
41976159 | Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis. | Ulcerative colitis (UC) is a multifactorial disease characterized by chronic intestinal inflammation and disrupted oxidative balance, significantly impairing patients' quality of life. Tannins, a class of polyphenolic compounds widely distributed in plants, have demonstrated notable therapeutic potential against UC due... |
41976018 | Effects of Fan Noise on Growth Performance, Blood Parameters, Feeding Behavior, and Slaughter Performance of Geese Aged 21-70 Days. | We conducted this experiment with the aim of investigating the effects of different noise levels from ventilation fans on the growth and slaughter performance, meat quality, blood parameters, and feeding behavior of geese from 21 to 70 days of age. A total of 108 male geese (21-day-old) were randomly assigned to one of... |
41972547 | Characterization of the Complete Mitochondrial Genome of <i>Nibea chui</i>: Resolving a Taxonomic Controversy and New Phylogenetic Insights into Sciaenidae. | <i>N. chui</i> is an economically important marine fish species distributed along the coastal waters of China, renowned for its delicate flesh texture and high-quality dried swim bladder. However, its scientific name and taxonomic relationship with <i>N. coibor</i> have long remained controversial, hindering accurate r... |
41972549 | In Silico-Identified Peptides of Five <i>Borrelia burgdorferi</i> Proteins Binding with High Affinity to Human Leukocyte Antigen (HLA) Class II Alleles. | To date, Lyme vaccine development has largely overlooked the vaccinee's human leukocyte antigen (HLA) genetic makeup on which antibody production critically depends. Here, we evaluated in silico the predicted binding affinities of 192 HLA-II alleles with all 15-mer peptide sequences of five <i>Borrelia burgdorferi</i> ... |
41970821 | A Facile and Biocompatible Hydrogel Based on Oxidized <i>Brachybotrys paridiformis</i> Polysaccharide for Enhanced Wound Healing. | <i>Brachybotrys paridiformis</i> polysaccharide (BPP) was extracted from the edible plant <i>B. paridiformis</i>, and its extraction conditions were systematically optimized using single-factor experiments combined with response surface methodology. Building upon the extracted BPP, an innovative hydrogel wound dressing... |
41970248 | Targeted delivery of lupeol via hyaluronic acid-modified ZIF-8 for anti-hepatic fibrosis therapy. | Hepatic fibrosis (HF), a common pathological consequence of chronic liver injury, is driven by the excessive proliferation and activation of hepatic stellate cells (aHSCs). Non-alcoholic steatohepatitis, the inflammatory form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alco... |
41955812 | Two-enzyme encapsulated nano metal organic framework hybrid probe based phage sensor for bioluminescent and electrochemical dual-mode detection of pathogenic bacteria bioactivity. | The assessment of both live and dead bacteria is critically essential for evaluating the infectivity and potential hazards of pathogenic microorganisms. In this study, the luciferase and lysozyme were initially encapsulated within a ZIF-8 MOF framework and further functionalized with an antimicrobial peptide (AMP) targ... |
41953479 | Atomic-level engineering of single-atom catalysts for selective C-C coupling in CO<sub>2</sub> hydrogenation to ethanol. | The selective hydrogenation of CO<sub>2</sub> to ethanol represents a pivotal route for sustainable carbon utilization and renewable fuel production, yet its efficiency is fundamentally constrained by the C-C coupling step, which plays the pivotal, rate- and selectivity-determining role in this reaction. Single-atom ca... |
41950754 | Construction and modification of a low-copy plasmid-based infectious clone for GI-19 genotype IBV via Red/ET recombineering: A simplified and efficient reverse genetics system for coronavirus. | Avian infectious bronchitis virus (IBV), a Gamma coronavirus (γ-CoV), is one of the most economically important pathogens affecting the global poultry industry. In this study, we established a novel reverse genetics platform of infectious clone of GI-19 genotype IBV. This platform integrates low-copy plasmid vectors wi... |
41930354 | The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives. | The central nervous system (CNS) maintains homeostasis and immune surveillance through a recently defined brain-wide clearance network: the glymphatic-lymphatic axis. This system couples the intramural glymphatic pathway, responsible for convective fluid transport and parenchymal waste removal, with the meningeal lymph... |
41930345 | The Application of Metal-Organic Frameworks as Drug Delivery Systems: From the Perspective of Molecular Dynamics Simulations. | Metal-organic frameworks (MOFs) have emerged as a promising class of nanomaterials for drug delivery due to their exceptionally high surface area, tunable pore structures, and chemical versatility. However, conventional experimental techniques cannot fully capture atomic-scale drug-carrier interactions or transient dif... |
41916206 | A computational study of perylene diimide as a potential nanocarrier for multiple drugs: adsorption, stability and release mechanisms. | Our investigation involves the analysis of perylene diimide (PDI) through DFT estimation, evaluating its potential as a drug carrier framework for Hesperetin, Melphalan, Mercaptopurine, Resveratrol, and Zidovudine. Analysis of the bond lengths between the interacting atoms indicates that PDI demonstrates exceptional ca... |
41916204 | A novel multifunctional and low toxicity Tb-MOF used for extremely sensitive detection of aspartic acid, ethyl maltol and rotenone in complex matrices. | Developing sensitive and biocompatible detection technologies is important for public health management and risk assessment. In this investigation, a new multifunctional Tb-MOF fluorescent nanomaterial was constructed, which has excellent structural stability and luminescent performance. It can achieve highly sensitive... |
41916180 | Asymmetric Fe<sup>3 +</sup>/Fe<sup>3</sup>⁻<sup>δ</sup> interfaces engineering in MOFs via boronic acid ligand substitution for targeted bioaerosol capture and inactivation. | Bioaerosols are posing an escalating threat to public health worldwide, exhibiting pathogenic potential even at environmentally relevant concentrations. Catalytic oxidation at room temperature can inactivate bioaerosols via reactive oxygen species (ROS) without external inputs, its practical efficacy remains constraine... |
41911973 | Hydroxypropyl-β-cyclodextrin/hyaluronic acid modified polydopamine nanoparticles co-loaded with BNN6 and epirubicin for synergistic photothermal/gas/chemotherapy of breast cancer. | Combination therapy, which integrates diverse treatment modalities to induce synergistic anti-tumor effects, has emerged as a promising strategy in oncology. In this study, we developed a near-infrared (NIR) laser-triggered nitric oxide (NO)-releasing and enzyme-sensitive targeted drug delivery system BNN6/EPI-HA@HP-PD... |
41905703 | Gene Therapy for Sickle Cell Disease: Practice Recommendations from the American Society for Transplantation and Cellular Therapy and the International Society for Cell & Gene Therapy. | Gene therapy has emerged as a transformative treatment option for individuals with sickle cell disease (SCD), with recent regulatory approvals marking a pivotal shift in clinical care. However, the complexity of patient selection, stem cell mobilization, manufacturing, conditioning, and long-term follow-up underscores ... |
41905036 | Enhancement of peroxidase-like activity of FeP-CoP<sub>3</sub> via precursor-shell engineering for tannic acid detection in beverages. | In this study, bimetallic phosphide (FeP-CoP<sub>3</sub>) was synthesized via a MOF-on-MOF strategy, using FeCo Prussian blue analogues (FeCo-PBA) as the precursor and zeolitic imidazolate framework-67 (ZIF-67) as the protective shell. Characterization via TEM, XRD and FTIR revealed that the loading of ZIF-67 induced t... |
41904127 | In-situ growth of biomimetic ion-selective membranes via confined molecular encapsulation for superior fluoride/chloride separation. | Biomimetic ion channels demonstrate potential for nanoscale molecular separations by leveraging their unique confined recognition capabilities. Metal-organic framework (MOF)-based mixed matrix membranes (MMMs) offer a promising platform that integrates the ångström-scale pores of MOFs with polymer processability. Howev... |
41903210 | In Situ Characterization Reveals an Impaired Fibril Response to Loading Following Unloading during Early Achilles Tendon Healing. | The Achilles tendon is the most frequently injured tendon in humans. Despite extensive research to understand its healing, there are still no clear rehabilitation guidelines to ensure full recovery and prevent reruptures. This could partly be due to limited understanding of how loading during tendon healing affects the... |
41903124 | Integrative computational analysis of Marburg virus protein mutations: structural and functional implications of Glycoprotein variants and natural inhibitor screening. | Marburg virus is a highly virulent filovirus responsible for severe hemorrhagic fever outbreaks with high mortality rates. This study aimed to (1) investigate the structural and functional consequences of mutations in major MARV proteins-particularly Glycoprotein (GP)-and (2) evaluate the antiviral potential of selecte... |
41903057 | High-Performance Perovskite Solar Cells and Modules via Slot-Die Coating: Engineering Advances, Photoluminescence Insights, and Future Perspectives. | Slot-die coating has solidified its role as the preeminent industrial-scale deposition technique for perovskite photovoltaics, combining exceptional material utilization, direct compatibility with roll-to-roll production, and high-throughput capability. This review comprehensively surveys recent advances in slot-die-co... |
41902979 | Harnessing biopolymeric double network hydrogels for cartilage repair: a review of current strategies. | Hydrogels with a double network (DN) structure that are based on carbohydrates have shown potential as scaffolds for the regeneration of cartilage. We postulate that these hydrogels can aid in the repair of cartilage and sustain the regeneration of tissue because of their ability to hold large quantities of water and l... |
41902836 | Direct Synthesis of High-Valence Protein@UiO-66 Composites: Linking Crystallization Pathways to Protein Encapsulation. | The direct synthesis of high-valence metal-organic frameworks (HV-MOFs) under biocompatible conditions remains an outstanding challenge due to the strong Lewis acidity and sluggish coordination kinetics of their metal centers. Here, we report a mild, aqueous synthesis of UiO-66-a benchmark Zr<sup>4</sup> <sup>+</sup>-b... |
41902752 | Bioinspired Nanofluidic Temperate Synthesis. | ConspectusThe development of new methodologies for efficient and selective catalysis under mild, green conditions is critical in synthetic chemistry. While nanoconfined catalysis has emerged as a powerful way for modulating reaction pathways, existing systems lack continuously interconnected confined channels and fail ... |
41902753 | A Cationic Eu-Based Metal-Organic Framework and Its Mixed Matrix Membranes for Sensitive Detection of Nitroaromatic Explosives. | Nitroaromatic explosives are hazardous substances, and their leakage poses severe threats to environmental safety, human health, and national security. Thus, the development of fluorescent probes capable of sensitive and rapid detection of nitroaromatic explosives is critically important. Although lanthanide-based meta... |
41902751 | Encoding Nucleobase Sequences to Synthetic Polyesters Using Adenine/Thymine-Containing Isocyanides as Gluing Components for the Passerini IEG. | DNA exhibits programmable self-assembly through complementary hydrogen bonding between nucleobases introduced to sugar-phosphate backbones in defined sequences, inspiring the development of synthetic analogs with nucleobases as recognition motifs. However, most nucleobase-containing polymers lack defined monomer sequen... |
41902748 | Dopamine D2 Receptor Isoform Heteroreceptor Complexes with the Growth Hormone Secretagogue Receptor 1a Reveals Isoform-Specific Interaction Interface Dynamics. | The dopamine D2 receptor (D2R), a class A G-protein-coupled receptor expressed in two isoforms at the central nervous system, has been implicated in several neuropsychiatric and neurodegenerative disorders. Although conventionally understood as a monomer, D2R can exist as homo- and heteroreceptor complexes, with each s... |
41902747 | An Fe(II)-Based Hexagon-Fused Wheel Constructed via Post-Synthetic Transmetalation. | Fe(II)-based supramolecules have attracted considerable interest in catalysis, environmental science, and biomedicine due to their low toxicity, low cost, and versatile oxidation states. However, the strong coordination affinity of Fe(II) often compromises the reversibility of self-assembly, and conventional one-pot sy... |
41902737 | Tetrapyrrole Complexes with Unusual Geometries: a Main Group Element Perspective. | ConspectusIn 1981, the year he won the Nobel Prize, Roald Hoffmann together with Kazuyuki Tatsumi published two papers entitled "Metalloporphyrins with Unusual Geometries" that strongly influenced the state of the art in porphyrin and tetrapyrrole research at that time. The 1970s and 1980s saw the dramatic expansion of... |
41902642 | Unravelling friction anisotropy by atomic force microscopy. | Friction plays a crucial role in both natural phenomena, from the flow of blood cells to earthquakes, and technological applications, from car engines to wind turbines. One of the most fundamental aspects of tribology is friction anisotropy, that is, the dependence of the friction force vector on the direction of slidi... |
41902560 | Kinetics-Optimized Crown Ether Engineering Enables Ultra-Flat Lithium Metal Interface for Long-Cycling 532 Wh Kg<sup>-1</sup> Pouch Cells. | Lithium (Li) metal batteries are plagued by erratic electrodeposition and unstable interphases. Achieving balanced Li ions (Li<sup>+</sup>) nucleation and diffusion kinetics is pivotal to address these obstacles and secure durable, uniform deposition. Herein, we present a molecular design strategy that decouples these ... |
41902541 | Dual-Site Photocatalysis With Titanium-Oxo Clusters and Single Metal Atoms for H<sub>2</sub> Evolution. | Rational engineering of photocatalysts with spatially separated photophysical and catalytic functions is an effective strategy to alleviate charge recombination and kinetic bottlenecks in solar hydrogen evolution. Herein, we developed a family of atomically engineered metal-organic frameworks (MOFs)-based photocatalyst... |
41902494 | A Host-Guest Supramolecular Approach to Boosting Consecutive Multi-Photon Excitation for the Arylation of Inert C(sp<sup>3</sup>)─H Bonds. | Biological photosynthesis harnesses multiple visible light photons to drive thermodynamically demanding reactions, whereas realizing analogous multi-photon excitation in artificial photosynthesis remains challenging. Inspired by enzymatic cascades, we herein report a host-guest supramolecular approach to boosting conse... |
41902492 | DMF-Mediated Diffusion Regulation in Pyridine-Carboxylate Metal-Organic Frameworks Enables Efficient CHF<sub>3</sub> Capture. | The development of efficient, stable, and easily scalable adsorbents, which are designed for the recovery of high-purity trifluoromethane (CHF<sub>3</sub>) from industrial waste gas, faces significant challenges. Here, we present a solvent-docking strategy for synthesizing a new metal-organic framework, PAIF-101 (Pyrid... |
41902477 | The Synergism of β-Cyclodextrin and Fe<sup>3+</sup> Enabled Anti-Swelling Ion-Conductive Hydrogels for Multimodal Underwater Sensing Aided by Machine Learning Algorithms. | As the key sensing component of flexible sensors, conductive hydrogels are prone to mechanical property degradation and signal deterioration owing to water absorption and swelling in underwater environments. Herein, an anti-swelling ion-conducting hydrogels are designed by incorporating ferric chloride (FeCl<sub>3</sub... |
42006725 | Self-assembled nanoparticles from Xiexin Decoction attenuate ulcerative colitis by targeting VDAC1-Mediated NLRP3 inflammasome activation. | Ulcerative colitis (UC) remains a clinical challenge due to limited efficacy and side effects of conventional therapies, highlighting the need for novel interventions. Here, we investigate the therapeutic potential of naturally derived self-assembled nanoparticles (XDNPs) from the traditional Chinese medicine formula X... |
42006352 | Photocatalytic performance and mechanism of oxygen-doped g-C<sub>3</sub>N<sub>4</sub> and photoactivated peroxymonosulfate on rhodamine B. | Organic pollutants such as dyes and pharmaceuticals pose serious threats to aquatic ecosystems and human health, highlighting the need for efficient advanced oxidation processes. Here, oxygen-doped graphitic carbon nitride was synthesized by co-calcination of melamine and cyanuric acid and applied to a photoactivated p... |
41978129 | Ginger Bioactives as Multi-Target Therapeutics: Mechanisms, Delivery Innovation, and Human Health Impact. | <b>Background/Objectives</b>: Ginger has a long history as both a culinary and medicinal plant and is widely recognized in traditional medicine for its ability to promote health and well-being. The principal bioactive compounds of ginger are present in fresh and dried forms and have been largely studied for their thera... |
41978126 | Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications. | <h4>Background</h4>Obesity is a chronic metabolic disease that has emerged as a major global public health concern. Obesity complications refer to a range of metabolic, neurological and behavioral disorders. Complex interaction mechanisms exist between obesity and the brain, including neuroendocrine regulation, center ... |
41977690 | Interactions Between Root Traits and Fungal Functional Guilds Across the Root Economics Spectrum. | Soil fungi play a pivotal role in maintaining ecosystem functions and regulating plant health. Although plant root traits can significantly impact the abundance and diversity of different fungal groups, the mechanism by which plant root strategies drive the assembly of soil fungal guilds remains limited. Utilizing Root... |
41977569 | Bioprinting in Tissue Repair and Its ENT Applications. | Biotissues represent a new technology in tissue regeneration in otolaryngology. Various biomaterials functioning in different combinations are used as bioinks for 3D bioprinting of tissues/tissue fragments. The scaffolds can be populated with several cell categories, each offering distinct advantages and disadvantages,... |
41977571 | Navigating the Bio-Composite Landscape: A Strategic Reconstruction of Electrospun Starch-Zein Nanofibers. | The transition from petrochemical plastics to sustainable biopolymers has created a critical demand for functional materials that do not compromise on performance. Starch and zein, due to their abundance and complementary nature, represent not just a chemical pair, but a techno-economic symbiosis: zein provides the hyd... |
41977567 | Single-Step Phytate Flame-Retardant Coatings for Cotton, Polyester and Cotton/Polyester Blends. | Scalable halogen-free flame-retardant textile finishes remain challenging, particularly regarding laundering durability and industrially viable processing. Here, two phytate flame retardants, poly(vinylammonium) phytate (PVAmPA, partly bio-based) and chitosan phytate (ChiPA, fully bio-based), were applied to cotton (CO... |
41977256 | Intrinsic Tumor Aggressiveness Dictates Hypoxia-Driven Metabolic Programs in Hepatocellular Carcinoma. | Hypoxia, a hallmark of hepatocellular carcinoma (HCC), regulates metabolic reprogramming, tumor progression, and therapy resistance. Although hypoxia-induced glycolytic changes are recognized, it remains unclear how intrinsic tumor aggressiveness influences the magnitude and plasticity of metabolic and transcriptional ... |
41977264 | Linker Engineering in Stapled Peptides for Enhanced Membrane Permeability: Screening and Optimization Strategies. | The optimization of membrane permeability is a pivotal approach for mitigating late-stage failures in peptide drug development. By leveraging linker chemical diversity, stapled peptides utilize linker engineering to precisely modulate key physicochemical parameters-such as lipophilicity and conformational constraints-t... |
41977250 | Imaging Techniques for the Study of Protein Condensates and Filaments and Their Applications. | Protein condensates and filaments are both intracellular structures characterized by their ability to facilitate specific biological functions. Their formation is primarily driven by phase separation, which can be elucidated by fluorescence microscopy or electron microscopy. Here we summarize the main studies on protei... |
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