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41772850 | Vaccines at the Heart of Hepatitis Elimination: Insights From the ESCMID Study Group for Viral Hepatitis (ESGVH). | The global elimination of viral hepatitis by 2030 remains an ambitious goal that hinges not only on diagnostics and therapeutics but fundamentally on the strategic use and continued innovation of vaccines. The ESCMID Study Group for Viral Hepatitis (ESGVH) convened to examine the role of vaccination as the cornerstone ... |
41772808 | Unveiling nuclear localization signals in human arginine deiminase proteins. | Arginine iminohydrolases are a family of enzymes involved in the conversion of arginine to citrulline. There are five isoforms in humans (PADI1, 2, 3, 4, and 6). Some of them are observed experimentally in the cytoplasm and in the nucleus of the cell; for moving to the latter location, they must pass through the cell n... |
41766160 | Synergistic Inhibitory Effect and Mechanism of Action of Cinnamaldehyde-Carvacrol Nanoemulsion on the Staphylococcus aureus and Escherichia coli Mixed Biofilms Formation. | The formation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) mixed biofilms challenges the treatment of bacterial infections. In this study, the synergistic effect of plant essential oils cinnamaldehyde (CA) and carvacrol (CV) on inhibiting S. aureus and E. coli mixed biofilms formation was investi... |
41758014 | Eucalyptus volatiles recognition mechanism of chemosensory protein 5 in Endoclita vietnamensis (Lepidoptera: Hepialidae). | Endoclita vietnamensis (Buchsbaum & Grehan) (Lepidoptera: Hepialidae) is a major stem-boring pest of eucalyptus. Host location in this species is critically dependent on the larval olfactory recognition of eucalyptus volatiles. However, the volatile recognition mechanism of E. vietnamensis remains unclear. To provide a... |
41717896 | Advances in Analytical Strategies for Precise Quantification of Topoisomerase Inhibitors: Current Trends and Future Directions. | Topoisomerase inhibitors (TIs) are a cornerstone class of anticancer and antimicrobial agents, yet their accurate quantification in pharmaceutical formulations and biological matrices remains analytically challenging. These difficulties stem from marked structural diversity, poor aqueous solubility, narrow therapeutic ... |
41704081 | The Effect of Free and Nanoliposomal Curcumin on the Viability and Acid Production of Single-Species (Streptococcus mutans) and Polymicrobial Biofilms. | <h4>Objectives</h4>Dental caries is a global health concern caused by the formation of cariogenic biofilms and their acid production. While various approaches have been tried, the rise of antibiotic-resistant microorganisms necessitates safer and more effective antimicrobial solutions. Natural substances can be safe an... |
41655242 | Genetic identification of Pid3-1 and its regulatory role in promoting blast resistance in rice. | Rice blast is a destructive rice disease caused by the fungus Magnaporthe oryzae. Here, we identified a resistance gene from the rice cultivar Wanhui 66 which is resistant to the rice blast Guy11 isolate. Genetic mapping positioned a blast resistance locus to chromosome 6. Employing map-based cloning approach ultimatel... |
41653011 | A genetic screen for regulators of Drosophila histone H1 binding and chromosome structure in vivo. | Histone H1 and related linker histones play critical roles in chromosome organization in eukaryotic cells. Although histone H1 is essential for compacting nucleosomes into chromatin fibers and is a major structural component of chromosomes, its association with chromatin is highly dynamic. Histone H1 exchange modulates... |
41648904 | Investigation into the docking of odorant binding proteins from tea green leafhoppers with host plant volatile components. | Insects possess an intricate and efficient olfactory system that plays a critical role in navigating their environment, facilitating host location, defensive maneuvers, and reproductive behaviors. In the present study, 12 biological samples were successfully sequenced, yielding a total of 79.92 G data. This led to the ... |
41644295 | A Phase 0 Imaging Trial of [<sup>203</sup>Pb]Pb-VMT-α-NET to Enable Dosimetry and Treatment Planning for Refractory or Relapsed Metastatic Neuroendocrine Tumors with [<sup>212</sup>Pb]Pb-VMT-α-NET. | Peptide receptor radionuclide therapy (PRRT) using α-particle emitters has potential to provide improved patient outcomes over those achieved with β-particle PRRT. A promising candidate radiopharmaceutical pair, PSC-PEG<sub>2</sub>-TOC (VMT-α-NET) conjugated to <sup>203</sup>Pb for SPECT/CT imaging or <sup>212</sup>Pb ... |
41628884 | Predicting the topography of fitness landscapes from the structure of genotype-phenotype maps. | Ruggedness-the prevalence of fitness peaks-and navigability-the existence of fitness-increasing paths to a target-are key factors affecting evolution on fitness landscapes. Here, we analyze these properties in landscapes that inherit biophysically grounded genotype-phenotype (GP) maps. By assuming a random phenotype-fi... |
41612937 | Xyloglucan endotransglucosylase/hydrolase family genes are required for the plant graft union formation through callus proliferation. | Plant grafting, a series of tissue reunion processes, exhibits varying levels of compatibility across different species. Despite extensive research, the response of the scion to various compatible rootstocks remains poorly understood. In this study, we utilized transcriptomic analyses and gene functional validation exp... |
41553373 | Dissecting the ROS signalling component of salinity tolerance: tissue-specific K+/Na+ homeostasis in quinoa and spinach roots. | This study combines electrophysiological, imaging, and molecular techniques to compare reactive oxygen species (ROS)-mediated K+/Na+ regulation in the root elongation zone (EZ) and mature zone (MZ) of halophytic quinoa (Chenopodium quinoa) and glycophytic spinach (Spinacia oleracea). Under salinity stress, quinoa exhib... |
41553251 | Sustained copper-releasing adhesive hydrogel patch promotes optimized scarless tongue wound healing <i>via</i> antioxidative, angiogenic and antifibrotic synergy. | Tongue injuries are among the most common acute soft tissue injuries encountered in oral clinical practice. Suturing, as the conventional treatment, often leads to tissue distortion and tension-induced collagen over-deposition, resulting in scarring and restricted tongue mobility. Sutures are also prone to microbial ac... |
41534092 | A Double-Negative Prostate Cancer Subtype Is Vulnerable to SWI/SNF-Targeting Degrader Molecules. | Proteolysis-targeting chimera (PROTAC) therapies degrading SWI/SNF ATPases interfere with androgen receptor (AR) signaling in AR-dependent castration-resistant prostate cancer (CRPC-AR). To explore the utility of SWI/SNF therapy beyond AR-sensitive CRPC, we investigated SWI-/SNF-targeting agents in AR-negative CRPC. SW... |
41490149 | Emerging Strategies to Inhibit the G1/S Transition for Cancer Therapy. | At its core, cancer is a disease of uncontrolled cell proliferation mediated by perturbed molecular pathways that have been elucidated over the past few decades. Biochemical and genetic studies have identified the key molecular regulators of the transition from G1 to S phase in the cell cycle that commits cells to divi... |
41428972 | Small-molecule inhibition of γ-glutamyl carboxylase reveals a novel anticoagulant strategy. | <h4>Abstract</h4>Oral anticoagulants such as warfarin, which function as vitamin K antagonists (VKAs), have long been central to anticoagulation therapy. Warfarin inhibits vitamin K epoxide reductase (VKOR), thereby restricting the availability of reduced vitamin K and impairing γ-carboxylation and activation of vitami... |
41270153 | Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia. | Whereas FMS-like tyrosine kinase-3 (FLT3) inhibitors have significantly improved the treatment of aggressive FLT3-mutated acute myeloid leukemia (AML), the emergence of resistance remains as a major challenge. In this study, we applied our recently developed single-cell lineage-tracing method ReSisTrace to identify cel... |
41258873 | Pathogenic mechanism underlying parkinsonism induced by neurotoxicants (MPTP and 6-hydroxydopamine) and α-synuclein: a unifying hypothesis. | The mechanism underlying the selective loss of dopaminergic neurons in Parkinson's disease (PD) is still not understood at present. MPTP, an illicit drug contaminant, can selectively induce parkinsonism in humans and animals which is very similar to idiopathic PD. Like MPTP, 6-hydroxydopamine (6-OHDA) is another neurot... |
41121984 | A Novel Dual-Payload ADC Platform Integrating Exatecan and Triptolide to Enhance Antitumor Efficacy and Overcome Resistance. | Antibody-drug conjugates (ADC) that utilize DNA topoisomerase I inhibitors, such as deruxtecan and SN-38, have significantly enhanced the efficacy of cancer treatment. However, the development of more effective ADCs to combat drug-resistant tumors remains a critical challenge. ADCs covalently link the topoisomerase I i... |
42006731 | FAP-targeting peptide-directed nanoprobes enable tumor microenvironment-activatable MR/NIRF imaging of breast cancer primary tumor and lung metastases. | Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed in tumor stroma, has emerged as a dual-purpose biomarker for cancer theranostics. Although FAP-targeting molecular imaging enables precise tumor visualization, its application for microenvironment-responsive detection of breast cancer me... |
42006722 | Dual-functional hydrogel platform suppresses M1 activation and stabilizes M2 macrophages in intervertebral disc degeneration. | Immune infiltration is a key factor of inflammatory responses and tissue remodeling during tissue injury and degeneration. In the immune microenvironment of degenerated intervertebral discs, the dynamic balance between M1 and M2 macrophage polarization is disrupted, impairing both frontline anti-inflammatory defense an... |
42006713 | CGRP-empowered stem cell sheet/short nanofiber sponge <i>via</i> enhancing neurovascular coupling for bone regeneration. | Functional repair of critical-sized bone defects is highly dependent on the synergistic establishment of a neurovascularized microenvironment. However, current strategies face a critical bottleneck: the lack of effective coupling and synchronization between newly formed blood vessels and regenerating nerves. This "deco... |
42006712 | Mannosylated graphene oxide nanotherapeutics co-delivering docetaxel and a STING agonist reprogram myeloid cells and potentiate antitumor immunity. | In triple-negative breast cancer (TNBC), tumor-associated macrophages (TAMs) and tumor-infiltrating dendritic cells (TIDCs) often exhibit an immunosuppressive phenotype. This myeloid-dominant milieu reinforces an immune-cold state, promotes metastasis and contributes to immunotherapy resistance. In this study, we devel... |
42006649 | Quantitative analysis and visualization of live spotted seabass (<i>Lateolabrax maculatus</i>) flesh texture using hyperspectral imaging and machine learning. | Flesh texture is one of the most important quality traits determining consumer satisfaction and perception of fish. Traditional methods for measuring flesh texture characteristics present several limitations. This study developed a rapid, efficient and non-invasive approach based on hyperspectral imaging (HSI) technolo... |
42006640 | The structure and extraction of silk fibroin and its applications in fruit and vegetable preservation: a review. | In response to increasing global demands for enhanced food safety and quality, the development of safe and efficient postharvest preservation technologies has emerged as a critical research priority in agricultural sciences. Silk fibroin, a naturally derived biopolymer, demonstrates remarkable potential for fruit and v... |
42004937 | Electrochemical sensor based on MWCNTs/ZnONPs for detection of prostate specific antigen. | An electrochemical immunosensor based on multiwalled carbon nanotube/zinc oxide nanoparticle (MWCNTs/ZnONPs) composites was fabricated for the sensitive and selective detection of prostate-specific antigen (PSA), an established biomarker for early prostate cancer diagnosis. The MWCNTs/ZnONPs-modified screen-printed car... |
42004349 | Uranyl Recognition through Cucurbit[7]uril-Bipyridinium Carboxylate Pseudorotaxanes as Supramolecular Chelators. | Exploration of new ligands for actinide recognition is desirable for developing more efficient separation processes, and pseudorotaxane-type supramolecular complexes have the attributes of simple synthesis and structural adaptability. In this work, we propose two novel CB[7]-based bipyridinium carboxylate pseudorotaxan... |
41993987 | Emerging liquid biopsy markers in thyroid cancer: from isolation technologies to clinical translation. | Diagnosis and treatment of thyroid cancer (TC) are undergoing radical changes, shifting from traditional tissue studies to liquid biopsies (LB). LB technologies provide effective, non-invasive solutions to these challenges. This paper reviews recent advances in the analysis of three important biomarker systems: circula... |
41993887 | In Silico Analysis of Potential Stabilizer Binding Sites at Protein-RNA Interfaces. | Stabilizing rather than interfering with protein-protein interactions has emerged as a promising concept for designing drug molecules that can modulate protein-protein interactions. In addition to protein-protein interactions, protein-RNA interactions are involved in numerous cellular metabolic and regulatory processes... |
41988635 | Exploring the treatment of osteomyelitis based on nanozyme-based antibacterial strategies. | Osteomyelitis is a severe bone infection caused by bacterial invasion, posing significant therapeutic challenges due to biofilm formation and antibiotic resistance. In recent years, nanozymes-a class of functional nanomaterials with enzyme-like catalytic activities-have shown considerable potential in antimicrobial app... |
41988593 | Self-Formation of Nanoporous Metal-Organic Framework/Water Interphase. | The reduction of the energy cost of environmental remediation processes is one of the major issues that afford modern societies. Colloidal nanoparticles of molecular sieve-type materials are widely used as adsorbents and catalysts in separation, conversion, and recovery processes, but still show limitations during thei... |
41988482 | Targeting KasA: isosakuranetin derivatives as promising scaffolds for novel anti-tuberculosis agents against drug-resistant <i>Mycobacterium tuberculosis</i>. | <h4>Introduction</h4><i>Mycobacterium tuberculosis</i> remains a major global health threat due to the rising prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, which limit the effectiveness of current therapies. The ß-keto-acyl carrier protein synthase (KasA), a key enzyme in the FAS... |
41988384 | The role of extracellular vesicles in the transport and regulation of novel inflammatory mediators in IBD and its associated CRC. | Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a chronic inflammation of the gut characterized by an imbalance in the intestinal microbiome and ecology. IBD raises the risk of developing colorectal cancer (CRC). CRC is one of the most commonly diagnosed cancers in the ... |
41988136 | Hypoxic microenvironment in cancer: role in metabolic reprogramming. | Hypoxia, a defining hallmark of solid tumors, arises from structurally and functionally abnormal vasculature, rapid cellular proliferation, and impaired perfusion, resulting in chronic and cycling oxygen deprivation within the tumor massThe hypoxic tumor microenvironment orchestrates extensive molecular reprogramming p... |
41987899 | Galectin-8 binds HIV envelope glycoproteins with high affinity and promotes viral infectivity. | Target cell entry of HIV-1 is dependent on the binding of gp120, the outer component of the viral envelope glycoprotein complex (Env), to CD4 and a coreceptor, preferentially CCR5 or CXCR4. Still, other interactions may also contribute to the infectivity of the virus. One such interaction is between the highly glycosyl... |
41977730 | Integrating Hyperspectral Data and Deep Learning for Non-Destructive Prediction of Tea Quality Parameters Across Different Physical States of Tea Leaves and Growth Periods. | Achieving rapid and non-destructive assessment of tea quality is essential for intelligent tea production and quality control. In this study, an integrated hyperspectral and deep learning framework was developed to estimate tea quality constituents across seasons and physical states. Samples included field fresh leaves... |
41977597 | Shear-Responsive Supramolecular Preformed Particle Gel: Tailoring Network Architectures for Selective Water Blocking. | Managing excessive water production in oil fields during primary, secondary, or enhanced recovery remains challenging. It increases costs and reduces hydrocarbon recovery, particularly in reservoirs with high-conductivity pathways such as high-permeability zones and fractures. Hydrogels are commonly used for water bloc... |
41977594 | Antimicrobial Effect of Cellulose Nanofibrils (CNFs) and Biobased Additives in Polyvinyl Alcohol Nanocomposite Materials for Sustainable Food Packaging Application. | This study investigates the development of polyvinyl alcohol (PVA)-based nanocomposite films reinforced with cellulose nanofibrils (CNFs) and biobased additives derived from blueberry pruning waste for sustainable food packaging applications. The nanocomposites were fabricated via solvent casting and evaluated in terms... |
41977374 | HIV Promoters Isolated from Brain and Peripheral Tissue of Virally Suppressed PWH Are Phylogenetically and Functionally Similar. | Despite viral suppression with antiretroviral therapy (ART), reservoirs of Human Immunodeficiency Virus (HIV) persist in anatomical compartments throughout the body, including the brain. We have previously demonstrated that the HIV long terminal repeats (LTRs) isolated from the brains of non-virally suppressed people w... |
41977352 | Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAF<sup>V600D,V600E</sup> PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells. | Late-stage metastatic cutaneous melanoma (MCM) and neuroblastoma (NB) are the most aggressive skin and childhood cancers with survival rates of <50%, mainly due to the emergence of resistance to available drugs, thus requiring an urgent solution. Quaternary phosphonium salts (QPSs) can exhibit strong anticancer effects... |
41977356 | Ginsenoside-Mediated Ferroptosis Regulation: Bidirectional Effects and Therapeutic Potential in Diseases. | Notably, certain ginsenoside components exhibit distinct bidirectional and context-dependent regulatory effects on ferroptosis depending on the disease setting. In aberrantly proliferating or activated cells, ginsenosides function as ferroptosis inducers, whereas in damaged quiescent cells of normal tissues, they act a... |
41976687 | Stimuli-Responsive Carriers for Delivery of Anticancer Bioactive Agents. | The review describes advances in stimulus-sensitive carriers for chemotherapy of various organs, since selectivity in cytotoxicity against cancer and normal cells is a key factor in effective cancer treatment. Special attention is devoted to particle carriers composed of natural compounds, such as lipids, phospholipids... |
41976204 | Highly Efficient Mineralization of Typical PPCPs in Medical Wastewater via P25TiO<sub>2</sub> Photocatalysis Under Sunlight Irradiation. | Pharmaceuticals and personal care products (PPCPs), as persistent organic pollutants, are widely present in various aquatic environments. Their long-term presence in aquatic environments poses a potential threat to ecosystems and human health. This study established an efficient, green, and cost-effective photocatalyti... |
41976202 | Design, Synthesis, and Self-Assembly of Amphiphilic 1,4-Dihydropyridines Containing Branched Ester Moieties. | Amphiphilic cationic lipids based on the 1,4-dihydropyridine (1,4-DHP) scaffold represent a versatile platform for the development of self-assembling delivery systems. In this work, a series of ten new amphiphilic 1,4-DHP derivatives bearing branched ester substituents at the 3,5-positions and quaternized cationic grou... |
41976200 | Synergistic Integration of Liposomes with Emerging Technologies for Food Applications. | Food by-products have gained importance as valuable sources of bioactive compounds and structural lipids, with potential applications in food packaging. These residues, such as fruit peels, seeds, and fish skin, contain polymers and natural compounds like polyphenols, carotenoids, tocopherols, and phospholipids, which ... |
41976192 | Flow Chemistry as an Enabling Technology for Process-Intensified Amination Reactions: A Decadal Review. | Amines are indispensable structural motifs in pharmaceuticals, agrochemicals, functional materials, and beyond, driving continuous demand for efficient synthetic methods. While established strategies like cross-coupling and reductive amination are prevalent, traditional batch processes often suffer from limitations in ... |
41976193 | Orange Seed Powder as a Novel Biosorbent for Congo Red Removal: Adsorption Mechanism, Isotherms, Kinetics, and Molecular Simulations. | The increasing discharge of synthetic dyes into industrial wastewater necessitates sustainable and low-cost treatment strategies. This study valorizes orange seed powder (OSP), an abundant agro-food residue, as a novel biosorbent for Congo red (CR) removal through a combined experimental and molecular simulation approa... |
41976042 | Development of an LC-MS/MS-Based Analytical Method, In Vitro Characterization, and Pharmacokinetic Study of Rafoxanide Nanosuspension in Sheep. | This study aimed to establish a more sensitive and reliable quantitative method for determining rafoxanide (RFX) in ovine plasma. The method was applied in an 84-day long-term comparative pharmacokinetic trial to evaluate the performance of a rafoxanide nanosuspension (RFX-NS) versus its conventional suspension (RFX-S)... |
41976044 | Candida Infections in Marine Mammals: Epidemiology, Antifungal Resistance, and One Health Implications. | <i>Candida albicans</i> is currently considered one of the most significant fungal pathogens in cetaceans and pinnipeds and the spread of antifungal-resistant strains pose significant threats to animal health and One Health concerns. Although <i>C. albicans</i> is the most commonly detected species, non-<i>albicans Can... |
41972720 | Diagnostic and Therapeutic Applications of Exosomes in Lung Cancer. | Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with a five-year survival rate of only 26%, primarily due to late-stage diagnosis and limited treatment options. Exosomes, nanosized extracellular vesicles released by nearly all cell types, have emerged as promising tools in both diag... |
41972648 | Mechanistic and Life-Cycle Framework for Green Nanomaterials in Atmospheric Water Harvesting. | Atmospheric water harvesting (AWH) has been recognized as a promising technology to address global freshwater scarcity in a decentralized manner. Nevertheless, conventional AWH sorbents are often associated with high energy consumption, toxic synthesis procedures, and short operational lifetimes. To address such limita... |
41972647 | Enhanced Polarization in Ferroelectric Composites via DIW-Controlled Perovskite Nanosheet Orientation. | PVDF has expanded the application of ferroelectric materials in flexible and wearable electronics due to its flexibility, corrosion resistance, ease of processing, and low cost. However, the polarization of ferroelectric polymers is low, with a bottleneck value of 10 µC cm<sup>-2</sup>. In this study, flexible ferroele... |
41972646 | Preparation of Fe<sub>3</sub>O<sub>4</sub>@ACF Composite Catalytic Electrode and Study of Its Degradation of Antibiotics. | Antibiotics are extensively used in intensive livestock farming for disease prevention, resulting in the discharge of antibiotic-contaminated wastewater into aquatic environments. Addressing this issue, electrocatalytic oxidation has emerged as a promising alternative to conventional chemical oxidation due to its cost-... |
41972644 | Interplay Between Exfoliation and Functionalization Strategies for Group VI Layered Transition Metal Dichalcogenide Dispersions. | The ability to efficiently tailor the surface properties of layered transition metal dichalcogenide (LTMD) dispersions is critical for optimizing performance and enabling scalable manufacturing techniques, such as spray coating and inkjet printing, for optoelectronic, energy storage, and sensing applications. Group VI ... |
41972641 | Modular Development of a <i>Klebsiella pneumoniae</i> Bioconjugate Nanovaccine Elicits Robust Protection via Intranasal Immunization. | <i>Klebsiella pneumoniae</i> poses a severe global health threat due to its extensive antibiotic resistance. However, to date, no vaccine against this pathogen has been approved for clinical use worldwide. Although self-assembling nanocarriers present distinct advantages for vaccine design, their ability to effectively... |
41972643 | Polyoxometalates (POMs) Memristors/Neuromorphic Devices: From Structure Engineering to Material and Function Integration. | The advancement of artificial intelligence and information technologies has presented higher demands on neuromorphic computing information devices, entailing the emergence of next-generation devices. Polyoxometalates (POMs) are emerging as promising molecular nanomaterials for next-generation neuromorphic computing, pr... |
41972561 | The Metabolic Calibration of Female Immune Plasticity: From X-Linked Vulnerability to Precision Metabotyping. | The female immune system operates within an evolutionary stability-plasticity trade-off, where the physiological demands of pregnancy necessitate a considerable degree of regulatory T cell (Treg) plasticity. This essential flexibility, however, inherently lowers the threshold for autoimmune dysregulation. Recent mechan... |
41958863 | Solvent-temperature coupled hydride transfer controls product selectivity in the HSiR<sub>3</sub>/KO <sup><i>t</i></sup> Bu catalytic system. | The HSiR<sub>3</sub>/KO <sup><i>t</i></sup> Bu catalytic system affords a notable regioselective C-H silylation reaction using alkaline earth metals, yet its mechanistic origins and the temperature-dependent selectivity inversion remain unresolved. Here, we combine active learning neural network potentials with long-ti... |
41953484 | Photocrosslinking chemistry for direct photopatterning of colloidal nanocrystals: toward pixelated light emitting diodes and beyond. | Colloidal quantum dots (QDs) exhibit outstanding optoelectronic properties and solution processability, making them promising candidates for devices such as quantum dot light emitting diodes (QLEDs). The realization of integrated QD-based devices, particularly in QLED displays, necessitates patterning techniques that o... |
41953487 | Alkali metal cation effects for rapid C-H activation by iron(0) complexes. | Ion pairing with alkali metal cations offers a novel way to enhance the rate of C-H activation. This strategy is demonstrated here using diketiminate-supported iron(0) complexes, which previously were shown to activate the C-H bond of benzene slowly (hours at room temperature) and did not reach completion before decomp... |
41948173 | Research Progress of Nanodelivery Platforms in the Diagnosis and Treatment of Esophageal Cancer. | Esophageal cancer treatment has long been limited by the toxicity of radiotherapy and chemotherapy, multidrug resistance, and low immune response. Nanotechnology, with its precise targeting advantages, offers a new solution. This article reviews its core advances: first, achieving enhanced efficacy and reduced toxicity... |
41939436 | Targeted Therapy for Advanced Gastrointestinal Stromal Tumors: Evolution and Future Directions. | Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, with its pathogenesis primarily linked to activating mutations in the <i>KIT</i> or platelet derived growth factor receptor alpha (<i>PDGFRA</i>) genes. Surgical resection remains the standard curative treatment fo... |
41933802 | Chirality in hydrogels assembled from D- or L-amino acid derivatives regulates immunological responses during diabetic wound healing. | Immunomodulatory biomaterials that perform specific host immune responses have shown great prospects for immunotherapies and regenerative medicine. Although there is a growing recognition of chirality in manipulating cell behavior, the regulatory role of matrix chirality on immune cell function and heterogeneity is sti... |
41931903 | Application of polyoxometalate-based metal-organic framework modified magnetic black phosphorus nanosheets for phosphoproteome analysis. | In this work, polyoxometalate-based metal-organic framework modified magnetic black phosphorus nanosheets (Fe<sub>3</sub>O<sub>4</sub>/BPNSs/POMOF) were designed and constructed. The resulting composite exhibited high surface area, excellent hydrophilicity, and superparamagnetism. Fe<sub>3</sub>O<sub>4</sub>/BPNSs/POMO... |
41929776 | A journey to ITACA: Ion Tracking with Ammonium Cations Apparatus. | A unique feature of gas xenon electroluminescent time projection chambers (GXeEL TPCs) in ββ0ν searches is their ability to reconstruct event topology, in particular to distinguish "single-electron" from "double-electron" tracks, the latter being the signature of a ββ0ν decay near the decay endpoint Qββ . Together with... |
41929569 | Dual-targeted approaches in cancer therapy: integrating siRNA and chemotherapy for improved outcomes. | Clearly, a growing body of preclinical evidence demonstrates the improved anticancer efficacy of co-delivery for siRNA with chemotherapeutic agents by simultaneous modulation of MDR mechanisms and amplification of cytotoxic responses. Indeed, through siRNA-mediated silencing of the target genes, one might restore chemo... |
41924828 | More protein-ligand data are needed for AlphaFold-like models to enable drug discovery. | Structure-based drug design (SBDD) is an evolving paradigm that leverages protein structural information to improve small molecule therapeutic design. Building on more than 50 years of data curation from the Protein Data Bank, the recent emergence of protein structure prediction models (PSPMs) promises to enable new co... |
41924629 | Insights into the adsorption performance of temozolomide on T-based 2D nanosheets from DFT and COSMO calculations. | In this study, density functional theory (DFT) was employed to investigate the adsorption behavior and electronic interaction characteristics of the anticancer drug temozolomide (TMZ) towards T-graphene (T-G), T-boron nitride (T-BN), T-aluminum nitride (T-AlN), and T-gallium nitride (T-GaN). The primary objective of th... |
41924636 | Phytochemical profiling of <i>Euphorbia tirucalli</i> Linn. latex and evaluation of its <i>in vitro</i> antibacterial activity against resistant <i>Klebsiella pneumoniae</i>: an integrative network pharmacology and molecular dynamics simulation study. | A phytochemical investigation of <i>Euphorbia tirucalli</i> Linn. (F. Euphorbiaceae) latex resulted in the isolation of five known compounds, namely euphol (1), euph-8-enol (2), gallic acid (3), methyl gallate (4), and rutin (5). The chemical structures of the isolated compounds were unambiguously established by extens... |
41924571 | Decoding the tactics for coacervate pedestrian crossing the phospholipid membrane. | Coacervate microdroplets based on liquid-liquid phase separation (LLPS) have emerged as versatile models for protocells, membraneless organelles and smart drug delivery carriers. Understanding the mechanisms of coacervates crossing lipid membranes is of great significance in synthetic cell engineering, cell physiology ... |
41924308 | Multifunctional Engineered Metal-Organic Frameworks as Targeted Protein Degraders for Augmenting Cancer Therapy via Hexokinase 2 Degradation and Provoking Cuproptosis. | Cuproptosis, a newly identified form of copper-dependent programmed cell death, has emerged as a potential therapeutic strategy for cancer treatment. However, its antitumor efficacy was strictly limited by dysregulated glycolytic metabolism of tumor cells. Herein, we proposed multifunctional copper-based nano-PROTACs (... |
41924114 | Facile synthesis of Bi<sub>2</sub>O<sub>3</sub>/BiOX mixed-phase for electrochemical detection of paracetamol. | In recent times, paracetamol (<i>N</i>-acetyl-<i>p</i>-aminophenol) detection has become crucial due to its widespread clinical use combined with the public health issue of hepatotoxicity from overdose. In this research, mixed-phase Bi<sub>2</sub>O<sub>3</sub>/BiOX (X = Cl, Br and I) was synthesized at room temperature... |
41924100 | Phytogenic silver nanoparticles synthesized from <i>Dendrophthoe falcata</i> and <i>Ocimum tenuiflorum</i>: SERS and ultrafast nonlinear optical studies. | The surface enhanced Raman scattering (SERS) performance and femtosecond third-order nonlinear optical (NLO) properties of green synthesized silver nanoparticles (AgNPs) were systematically investigated in this work. Three dye molecules (nile blue-NB, crystal violet-CV and methylene blue-MB) and an explosive molecule (... |
41924112 | Smartphone-integrated sensing platform based on a "one-stone-three-birds" strategy for real-time quantitative detection of Ag(i) ions. | Heavy metal ion contamination poses a serious threat to human health and ecological balance, emphasizing the need for sensitive detection methods to maintain water quality and safeguard public safety. To meet this challenge, an integrated quantitative detection platform based on smartphone image capture and a built-in ... |
41924101 | Sulfonamide derivatives as tubulin polymerization inhibitors: advances in structural mechanisms, structure-activity relationships, and therapeutic potential in cancer treatment. | Cancer has been ranked as one of the major causes of death globally, with a rising trend in its incidence and resistance towards existing chemotherapeutic drugs. These necessitate the development of novel therapeutic strategies for the treatment of this deadly disease. Microtubules, which are integral to cell division,... |
41924099 | A review on β-cyclodextrin-based self-healable supramolecular systems: mechanisms and biomedical applications. | Supramolecular self-healing materials have attracted significant interest due to their capacity for autonomous damage repair, which enhances their durability and functional performance. This review examines the design strategies and recent advances in self-healing systems driven by host-guest interactions, with a parti... |
41923617 | TMEM145 is a principal component of outer hair cell stereocilia. | The exquisite acuity of mammalian hearing relies on cochlear amplification provided by sensory outer hair cells (OHCs), downstream of mechanoelectrical transduction of sound. In OHCs, transduction is initiated by deflection of stereocilia conveyed through tethering to the tectorial membrane (TM) via an incompletely cha... |
41917756 | Chiral Supramolecular Structures Formed by Dibenzo-18-crown-6-ether and NaCl/KCl on Au(111) and Cu(111) Surfaces. | The host-guest chemistry of crown ethers can be applied to construct chiral supramolecular nanostructures on metal surfaces. In this study, dibenzo-18-crown-6-ether (DB18C6E) molecules and alkali metal salts (NaCl and KCl) were codeposited on Au(111) and Cu(111) surfaces, and the formed supramolecular structures of the... |
41917753 | "Ammonia Induced Framework Transformations and Spin-Crossover in Fe(II) Hofmann MOFs". | Hofmann-type Fe(II) frameworks, [Fe(pz)M(CN)<sub>4</sub>] (pz = pyrazine; M = Pd, Pt), exhibit a dual-mode response to ammonia, arising from its strong Lewis basicity. Short-term NH<sub>3</sub> exposure produces reversible clathrates (<b>1-Pd@NH</b><sub><b>3</b></sub>, <b>1-Pt@NH</b><sub><b>3</b></sub>) that change fro... |
41917693 | Fibrillar and Micellar Aggregation of Semaglutide and Formation of a Chiral-Imprinted Glass. | Semaglutide is a therapeutically important lipopeptide that comprises a lipidated peptide with a glucagon-like peptide-1 (GLP-1) sequence, and may be prone to aggregation. We show that semaglutide in low pH 2.4 solutions forms β-sheet fibrils, in contrast to the oligomeric and micellar structures formed at higher pH. B... |
41917062 | Investigating Escherichia coli Colicin E9 immunity protein interactions with DNA gyrase of Pseudomonas aeruginosa: advanced computational approach for developing novel antimicrobial strategies. | Protein-protein interactions (PPIs) are essential to numerous cellular processes, making a thorough investigation of these interactions crucial for a deeper understanding of molecular mechanisms. This research initiative aims to elucidate the complex relationship between the Colicin E9 immunity protein from Escherichia... |
41917028 | Preventing peritendinous adhesions using lubricious supramolecular hydrogels. | Over 30-40% of 1.5 million annual hand flexor tendon injuries in the United States result in peritendinous adhesions which limit range of motion (ROM) and severely impact quality of life. Currently, no widespread solution exists for adhesion prevention in the delicate space of the digit while allowing full ROM quickly ... |
41917047 | Exploiting underpotential deposited hydrogen enables energy-efficient nitrate electroreduction to ammonia. | Electrochemical nitrate reduction in alkaline media offers a sustainable route for ammonia synthesis at rates rivaling those of the Haber-Bosch process. However, its energy efficiency is limited by sluggish nitrate deoxidation and hydrogenation, compounded by challenges in proton supply via H<sub>2</sub>O dissociation.... |
41917023 | A biomimetic nanodisc system selectively activates type I interferons by nonclassical STING pathway for cancer immunotherapy. | The epigenetic silencing or remarkably diminished expression of STING in cancer cells, along with the structural and functional impairment of the endoplasmic reticulum (ER) and Golgi apparatus, represents a unique mechanism of tumor immune escape and poses an important challenge for STING-targeted therapies. Here, we d... |
41916987 | Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter. | ATP-binding cassette (ABC) transporters are molecular machines involved in diverse physiological processes, including antigen processing by TAP, a key component of adaptive immunity. TAP and its bacterial homolog TmrAB use ATP to translocate peptides across membranes, yet the precise mechanism linking ATP binding to su... |
41916969 | Natural photosynthetic system for restoring homeostasis of animal organelle interaction network. | Disruption of organelle interactions due to metabolic stress is a crucial factor in the pathological processes of many degenerative diseases. Compared with animal cells, the participation of chloroplasts enables plant cells to show defensive adaptation under stress. Therefore, delivering plant-derived photosynthetic sy... |
41916933 | Beyond microtubule regulation: the multifaceted roles of tau in neuronal function and dysfunction. | The neuronal microtubule-associated protein tau is involved in several neurodegenerative diseases, collectively referred to as tauopathies. In these diseases, it aggregates and plays a central role in triggering cell death. Tau was originally identified as a factor that co-purifies with microtubules. Since then, it has... |
41916928 | 2D Laminated Hybrid Architectures Based on Graphene/Mesoporous Polyaniline for High-Performance Supercapacitor Electrode. | Graphene has emerged as a highly promising candidate for high-performance supercapacitor electrodes. Its atomically-thin 2D structure and exceptional physical properties provide an ideal foundational platform for designing hybrid nanomaterials, which are pivotal for advancing electrochemical performance metrics. Howeve... |
41916893 | Schiff Base-Wrapped Co, Zn-Based Clusters with Hierarchical Chiral Structures for Therapeutic Application in Parkinson's Disease. | Hierarchical chiral structures have wide applications in materials science and biomedicine. The synthesis of multilevel chiral structures with specific functions is a key issue. In this work, we have successfully designed and synthesized R/S-Co<sub>4</sub>Zn<sub>5</sub>L<sub>10</sub> (L = C<sub>16</sub>H<sub>15</sub>O<... |
41915900 | Three-Electrode, 3D-Printed NMR Cells for Electrooxidation Studies. | This study describes a novel experimental apparatus for monitoring electrochemical reactions by in situ NMR spectroscopy. A unique cylindrical 3D-printed electrochemical cell, incorporating a reference electrode, was developed to enable electrochemical measurements through exact potential control. The performance of th... |
41915887 | Leveraging Dynamic Electrostatic and Hydrophobic Interactions for Biomedical Hydrogels. | The reversibility of dynamic cross-links affords hydrogel-enhanced responsiveness to external stimuli, making them useful in a variety of biomedical applications. While numerous types of dynamic interactions exist, electrostatic and hydrophobic interactions are notably potent. Herein, recent reports are highlighted tha... |
41915852 | Post-Modification of Crystalline Peptoid Nanomembranes with Active Nanoparticles for Efficient Photo-Oxidation of a Mustard Gas Simulant. | Peptoids (or poly-<i>N</i>-substituted glycines) hold immense potential for assembling into hierarchically structured functional materials via controlled molecular interactions. To create self-assembled materials with tailored functionalities, peptoid sequences are often conjugated with reactive or recognition motifs t... |
41915808 | Direct Evidence from Multiscale Measurements Explains the Nonmonotonic Deposition of Microplastics in the Presence of Dissolved Organic Matter: Overlooked Contribution of Molecular Self-Assembly. | Microplastics (MPs) pollution constitutes a critically escalating global environmental challenge. Understanding dissolved organic matter (DOM)-MPs interactions and their transport behavior in soil and aquatic systems is of fundamental significance. However, contradictory observations regarding the impact of DOM on the ... |
41915717 | A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis. | Psoriasis vulgaris is a common chronic inflammatory skin disease associated with hyperproliferation and defective differentiation of keratinocytes. Despite new effective treatments using biologicals targeting key cytokines or their receptors, innovative therapeutic approaches remain to be discovered. Here, psoriasis-li... |
41915685 | New Histone H4 variant and H2B variant Exhibits distinct genomic distributions, chromatin affinities, and dynamics throughout life and cell cycle of Trypanosoma cruzi. | Histone variants play crucial roles in chromatin organization and transcriptional regulation in eukaryotes. Unusually, trypanosomatids display histone variants for all histones, although a functional homolog of histone H4 variant (H4.V) had not yet been described in Trypanosoma cruzi. In this study, we identified a H4.... |
41915665 | Mapping the mutational landscape of an avian retrovirus envelope protein across its evolutionary trajectory. | Many RNA viruses exhibit error-prone replication. Continuous generation of erroneous copies accelerates evolution. Avian leukosis virus subgroup J (ALV-J), an avian oncogenic virus, is a classical model virus for studying retroviruses. ALV-J's high mutation rates drive continuous evolution of its envelope and pathogeni... |
41915655 | Predicted antiviral potential of phytochemicals prolific in Cleistanthus bracteosus Jabl. and essential oils of Artemisia scoparia and Thuja orientalis against Nipah virus and Human metapneumovirus: An AI-driven in-silico study. | The recent Nipah virus (NiV) epidemic and human metapneumovirus (hMPV) outbreak have had a significant impact on human health and society worldwide. The attachment glycoprotein (G) and fusion glycoprotein (F0) of NiV and hMPV are essential for pathogenesis and are potentially pronounced targets for antiviral treatment.... |
41915568 | A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival. | Nucleomodulins are a class of effector proteins secreted by bacterial pathogens that translocate into the host cell nucleus to modulate nuclear processes. However, their target proteins and underlying molecular mechanisms remain poorly understood in mycobacteria. Herein, we identified a conserved hypothetical protein R... |
41915546 | Highly Selective and Irreversible Anion-Exchange in Two-Dimensional Bis(terpyridine)metal(II) Polymer Thin Films. | Bis(terpyridine)metal(II) polymers are functional coordination polymers characterized by cationic backbones containing exchangeable anions inside. Anion-exchange with functional anions can alter or create new properties through interactions between the cationic polymer backbones and anions. Although considerable resear... |
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