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41772598 | Bimodal nanobody agents for cancer imaging and potential intraoperative guidance: a systematic review. | Bimodal imaging tracers that combine nuclear and optical modalities are gaining increasing relevance for in vivo applications in oncology, particularly for surgical guidance, where both real-time visualization and preoperative deep-tissue localization are crucial. Nanobodies are heavy-chain antibody fragments that offe... |
41771826 | Thromboxane receptor activation in dendritic cells mitigates sepsis by suppressing S100a8/a9-mediated neutrophil recruitment. | Dendritic cells (DCs) regulate both innate and adaptive immunity during sepsis. Prostaglandins (PGs), small lipid molecules derived from arachidonic acid via COX enzymes, are crucial regulators of immune homeostasis and inflammation. However, their role in sepsis pathogenesis remains poorly defined. In this study, we i... |
41697695 | Crystallographic insights into (ImHR)<sub>2</sub>[TcBr<sub>6</sub>] (Im = imidazole, R = H, Me, Et): non-covalent interactions and mass spectrometry. | The structures of three Tc(IV) complexes (ImHR)<sub>2</sub>[TcBr<sub>6</sub>] (Im = imidazol-2-yl, R = H, Me, Et) are described. The compound (ImHMe)<sub>2</sub>[TcBr<sub>6</sub>] was obtained in two distinct polymorphic forms (space groups <i>P</i>1̄ and <i>P</i>2<sub>1</sub>2<sub>1</sub>2), arising from differences i... |
41685385 | Bicarbonate anion coordination assisted CO<sub>2</sub> capture by using urea-morpholine hybrid receptors in water. | The development of energy-efficient sorbents for aqueous CO<sub>2</sub> capture remains a significant challenge. This work presents a new design strategy by integrating a tertiary amine (morpholine) with a urea motif into a single molecular receptor. This structure enables autonomous, base-free CO<sub>2</sub> capture i... |
41674436 | Cu-exchanged phosphomolybdic acid induced a solvent effect to enhance alkene epoxidation with H<sub>2</sub>O<sub>2</sub>. | Solvent-mediated alkene epoxidation using H<sub>2</sub>O<sub>2</sub> oxidant is significantly enhanced by a Cu-substituted phosphomolybdic acid anchored on triphenylamine-functionalized porous organic polymers (CuPMA/POPs). The immobilization of the CuPMA cluster on the POP supports suppresses the stronger coordinative... |
41641896 | Synergistic pharmacotherapy for epilepsy: NPY (3-36)-modified ZIF-90 nanoparticles co-delivering GW2580. | Epilepsy is one of the most common neurological disorders, with current antiepileptic drugs (AEDs) being ineffective in up to 30% of patients. Moreover, the therapeutic efficacy of existing AEDs is significantly limited by the blood-brain barrier (BBB). The neuropeptide Y<sub>2</sub> receptor is a potential antiepilept... |
41636558 | Recent progress in NiFe-based catalysts for the high current density oxygen evolution reaction. | The global transition to green hydrogen <i>via</i> water electrolysis is constrained by the sluggish oxygen evolution reaction (OER), particularly at high current densities required for industrial applications. Among Earth-abundant materials, nickel-iron (NiFe)-based compounds have emerged as leading candidates, offeri... |
41582841 | Recent advances in reticular frameworks and allied composite materials for ultrasensitive optical detection of biogenic and volatile amines in food spoilage monitoring. | Food spoilage arising from protein degradation and microbial activities leads to the release of biogenic amines (BAs) and volatile amines (VAs), which compromise its quality and pose health hazards. Conventional chromatographic techniques for monitoring BAs and VAs, for example, HPLC, GC and spectrometry-based methods,... |
41924590 | Synergistic self-assembly and crosslinking yield a durable, bioactive, and injectable recombinant collagen implant for photoaging therapy. | Sustained ultraviolet (UV) irradiation upregulates matrix metalloproteinases (MMPs) activity, exacerbates collagen degradation, and triggers inflammatory signaling, leading to extracellular matrix (ECM) disorganization and skin photoaging. While animal-derived collagens are widely used in clinical applications, their i... |
41907199 | Understanding Solvent-Induced Glass Transition in Polymer Thin Films Using Absorption-Desorption Isotherms. | The fundamental thermodynamic and mechanical underpinnings of polymer thin films exposed to solvent vapor are critical for the development of advanced nanolithography and high-performance coatings. This work investigates the solvent-polymer interactions of glassy thin films by using the solvent absorption-desorption is... |
41901716 | <i>Acanthamoeba castellanii</i>: Non-Steroidal Anti-Inflammatory Drugs Affect Adhesion, Motility, and Encystment, Suggesting a Link with a gp63-like Protein Candidate. | <i>Acanthamoeba castellanii</i>, an opportunistic free-living amoeba, causes severe infections including Acanthamoeba keratitis. This exploratory study evaluated whether three non-steroidal anti-inflammatory drugs (NSAIDs)-acetylsalicylic acid, ibuprofen, and diclofenac (100 µM)-modulate pathogenicity-related processes... |
41900804 | Targeting Intratumoral Bacteria for Enhanced Tumor Suppression with Nano-Based Therapeutics: A Scoping Review. | <b>Background</b>: Increasing evidence identifies intratumoral bacteria as key modulators of tumor progression, chemoresistance, and immunosuppression, presenting major obstacles to conventional cancer therapies. Recent advances in nanotechnology have enabled new strategies for selective targeting bacteria within the t... |
41900807 | Phosphatidylcholine-Polysorbate 20-Based Mixed Micelles: A New Option to Prevent Protein Aggregation? | <b>Background/Objectives:</b> Surfactants are commonly used to protect proteins from denaturation and particle formation, thereby ensuring the long-term stability of biopharmaceuticals. Polysorbates (PS) 20 and 80 are the most widely used surfactants in the pharmaceutical industry. However, alternative excipients such ... |
41900330 | Review in Structure-Activity Relationships, Synthetic Regulation, and Applications of Mono/Di-Rhamnolipids. | Rhamnolipids (RLs) are natural biosurfactants produced by microbial fermentation. They exhibit excellent surface activity, environmental compatibility, and versatile biological activities, with broad application potential in energy development, environmental remediation, personal care, and biomedicine. In recent years,... |
41899417 | n-Butanol Extract of <i>Polygonum capitatum</i> Targets Biofilm Formation, Motility, and Adhesion Attenuation to Combat Uropathogenic <i>Escherichia coli</i>. | Uropathogenic <i>Escherichia coli</i> (UPEC) that form biofilms exhibit high-level antibiotic resistance, which poses substantial challenges to current therapeutic strategies for urinary tract infection (UTI). There is an urgent need for strategies specifically targeting UPEC biofilms. This study investigated the effec... |
41897461 | Nano-Cilostazol Mitigates Cisplatin-Induced Nephrotoxicity in Rats via Modulation of Oxidative Stress, Apoptosis, Pyroptosis, and miRNA-155 Signaling. | <h4>Background</h4>This study investigated the renoprotective potential of Nano-Cilostazol against cisplatin (CIS)-induced renal injury in male rats and explored its molecular mechanisms. Our results showed that Nano-Cilostazol has a favorable physicochemical characteristic, including a mean particle size of approximat... |
41893177 | Contact-Dependent Antibacterial Performance of Silver Nanoparticles Encapsulated in Collagen-Based Gels. | The design of new medical devices in biomedical engineering often necessitates the control of microbial load at the point of application, making antibacterial action valuable for numerous applications in the biomedical field. Nanotechnology products, such as silver nanoparticles (<i>AgNPs</i>), represent highly promisi... |
41892421 | Colistin Resistance: From Laboratory Research to Modern Clinical Management. | <b>Background/Objectives:</b> Colistin, a polymyxin antibiotic introduced in the mid-20th century, has regained clinical importance as a last-resort agent for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. The global dissemination of carbapenem-resistant pathogens has intensifie... |
41873331 | Porcine influenza mAbs to H3, H5, and H7 hemagglutinins recognize H3 egg adapted site and target the HA stem. | <h4>Introduction</h4>Monoclonal antibodies (mAbs) are critical tools for elucidating viral evolution, informing vaccine design, and developing antiviral therapeutics. Large-animal models, such as the pig, that closely mirror human immune responses are essential for understanding influenza immunity.<h4>Methods</h4>Pigs ... |
41867613 | Tuning Molar Mass of the D18 Polymer via Stille Polymerization: Impact on Morphology and Large-Area Blade-Coated Organic Solar Cells. | Achieving reproducible, high-performance organic solar cells (OSCs) requires precise control over the molar mass of donor polymers, as it governs film formation, morphology, and charge transport. Here, we systematically investigate the influence of Stille polymerization conditions on the molar mass, optoelectronic prop... |
41867605 | Functional Effects of Cyclization on Li1 Peptide Activity against Metacyclic <i>Leishmania amazonensis</i> Internalization. | Leishmaniases are caused by protozoa of the genus <i>Leishmania</i>, whose metacyclic promastigote forms initiate infection in the mammalian host. Building upon previous work with <i>Leishmania infantum</i>, this study evaluated the cyclic peptide Li1 and its linear analogue Li1nc regarding their capacity to interfere ... |
41867560 | Functional Analysis of Amino Acid Residues Responsible for Substrate Specificity of GH13_17 α‑Glucosidase from <i>Aedes aegypti</i> Saliva (AaMalI). | The α-glucosidase (AaMalI) in <i>Aedes aegypti</i> saliva belongs to glycoside hydrolase family 13, subfamily 17 (GH13_17) and plays a crucial role in the digestion of sucrose, which is the main sugar involved in insect metabolism. The amino-acid residues in the conserved region II have been reported as the key residue... |
41867553 | MOF-Derived ZnO Thin Films with Uniformly Dispersed Pt Nanoparticles for High-Performance Acetone Detection. | Acetone is a vital biomarker for noninvasive diagnosis of diabetes and metabolic disorders. However, its low concentration in exhaled breath and interference from other volatile compounds make its detection highly challenging. High surface area, uniform nanostructure, and precise catalytic surface decoration are key fa... |
41867551 | Phenolic-Enriched Pullulan Coatings: Molecular Interactions and Functional Properties for Active Food Packaging Applications. | Sustainable active coatings based on renewable polymers are increasingly sought for food-packaging applications; however, surface-applicable colloidal coating systems remain markedly underexplored compared to conventional bulk films. In practical applications, coatings are applied as liquid colloidal dispersions, which... |
41867546 | Machine Learning Methods for Protein-Protein Interaction Prediction Based on Noncovalent Interactions. | Given the pivotal role of noncovalent interactions in protein-protein interactions (PPIs), exploring the hidden patterns underlying the interaction data has become essential for deciphering and evaluating PPIs. In the current study, different types of noncovalent interaction data were generated from 44848 pdb files col... |
41854614 | Use and Implications of the Fracture Risk Assessment Tool in Primary Hyperparathyroidism. | <h4>Importance</h4>Although primary hyperparathyroidism (PHPT) increases the risk of osteoporotic fractures, estimation of fracture probability among patients with PHPT remains challenging. Use of the Fracture Risk Assessment Tool (FRAX) among these patients remains poorly characterized, and its utility in identifying ... |
41852883 | A glycopeptide hydrogel confers protection and treatment in sepsis via recruitment and training of macrophages. | Sepsis is a critical global health challenge, characterized by dysregulated host responses and high mortality rates. Current treatment therapies inadequately address persistent immunoparalysis and adverse reactions, leaving survivors susceptible to recurrent infections. Herein, we developed the first β-glucan (BG) deli... |
41847354 | Dysregulated interferon signaling and hyperinflammation upon <i>FCGBP</i> knockdown in goat bronchial epithelial cells infected with <i>Pasteurella multocida</i>. | <h4>Introduction</h4>The Fc gamma binding protein (FCGBP) is pivotal for mucosal immune defense against <i>Pasteurella multocida</i> (<i>P. multocida</i>), a key pathogen that induces respiratory ailments in ruminants. However, the mechanism by which FCGBP modulates the pulmonary immune response following infection rem... |
41847126 | Oleanolic acid and its derivatives in breast cancer therapy: mechanistic insights, structural modifications, and novel delivery strategies. | Oleanolic acid is a natural pentacyclic triterpenoid widely found in dietary plants and has attracted translational interest in breast cancer research. This review addresses how oleanolic acid and its derivatives exert anticancer effects in breast cancer models, and how structural modification and delivery strategies m... |
41846934 | Advances in <i>MICA</i> genotyping: characterization of 406 novel alleles and their frequencies in multiple populations. | In 2020, we reported <i>MICA</i> allele frequencies from a cohort of over one million German individuals. This study identified <i>MICA*008</i> (42%), <i>MICA*002</i> (12%), and <i>MICA*009</i> (9%) as the most common <i>MICA</i> alleles at protein resolution. Additionally, we discovered novel alleles with a cumulative... |
41846867 | Curcumin in oral health: mechanisms, clinical evidence, and delivery strategies. | Curcumin, a polyphenolic compound derived from the turmeric rhizome (Curcuma longa), has attracted significant interest in dentistry and oral medicine because of its multifaceted therapeutic properties. In particular, curcumin exhibits potent anti-inflammatory, antioxidant, and antimicrobial activities that are relevan... |
41846070 | Comparative phosphoproteomic analysis reveals regulatory mechanisms underlying muscle fiber density in goslings. | Muscle fiber density at hatching is closely associated with post-hatch meat yield through subsequent hypertrophy and with meat tenderness at market age. However, inter-individual variation in muscle fiber traits among goslings remains poorly understood. In this study, 129 one-day-old Yangzhou goslings were sampled and ... |
41836542 | Accurate prediction of cucurbituril binding affinities from guest molecular formulae. | The binding affinities of 24 ammonium salts were determined by isothermal titration calorimetry (ITC). The affinities were predicted with three empirical models that do not invoke the macrocycle explicitly. Once head groups common to all guests are removed, and the remaining fragments are transferred from aqueous solut... |
41833416 | Hydrovoltaic-photoelectric coupling effect boosted self-powered aptasensor for on-site and ultrasensitive monitoring of enrofloxacin in aquaculture products based on CdS/ZIF-67 heterojunctions. | On-site monitoring of antibiotic residues in aquaculture products is of great significance for providing instant content information to protect food safety and human health. In this work, a novel hydrovoltaic self-powered electrochemical sensor was fabricated for real-time sensitive detection of enrofloxacin (ENR) by i... |
41829320 | Polymeric Powders for Powder Bed Fusion: From Chemistry and Powder Characteristics to Process Parameters, Defects and Applications. | Polymer powder bed fusion (PBF) is strongly influenced by powder chemistry and powder state, yet many studies discuss the materials and processing conditions in isolation. This review synthesises the literature using a powder-centred framework that connects polymer chemistry and powder production history to measurable ... |
41828559 | Layers of Hope: How Graphene and Nanostructures Hold Promise for Cancer Therapy. | Cancer remains a challenge in modern medicine, characterized by high mortality rates and significant variability in treatment response. The urgent need for more effective and targeted therapies has driven the exploration of innovative strategies, including nanomedicine, which promises precise therapeutic delivery to tu... |
41815866 | Ultrasound-triggered dissolving microneedle platform for cGAS-STING-mediated precision immunotherapy of melanoma. | Melanoma is an aggressive skin cancer with a rapidly increasing global incidence. Immunotherapy via the cGAS-STING pathway has emerged as a promising strategy to enhance anti-tumor efficacy in melanoma, however, its clinical translation remains limited by several challenges. Herein, we reported an ultrasound (US)-contr... |
41815864 | Analgesic-loaded NIR-II photothermal hydrogel for efficient anti-infection and precise pain management in wounds. | Photothermal therapy (PTT) is widely recognized for the treatment of infected wounds. However, the wound hyperpathia caused by infection and heat from PTT is often overlooked, which might affect wound healing significantly. In this study, we systematically investigate the management of pain in bacteria-infected wounds ... |
41810421 | Revealing the influence of top-brewing and bottom-brewing methods on the flavor of green tea based on the interaction between EGCG and aroma compounds. | The brewing process is a crucial step in determining the flavor profile of green tea infusions. However, the flavor differences arising from top-brewing and bottom-brewing methods remain poorly understood, and the underlying mechanisms are largely unexplored. In this study, GC-MS and sensory analysis were employed to i... |
41809380 | Graphene oxide-microplastic hybrid showcase elicited discrepancy through intrinsic interaction mediated steatosis, and apoptosis in macrophages. | The widespread natural abundance of microplastics (MP) has been recognized to pose significant global health concerns, particularly due to limited understanding of their biological interactions. With the uncontrolled increase in MP accumulation in the environment, their interaction with xenobiotics like nanomaterials u... |
41798631 | Stepwise functionalization-induced molecular tweak unveiling multi-level thermochromic data encryption and fingerprint monitoring system. | Protecting hierarchical data <i>via</i> multi-level encryption and authenticating high-contrast touch traces represents an emerging frontier demanding technological innovation in molecular materials. Herein, <i>via</i> precise molecular interventions, three D-A-A' (donor-acceptor-acceptor) type aggregation induced emis... |
41795320 | Graphene oxide integrated PET waste-derived Cu-BHET metal-organic frameworks with superior antioxidant activity and accelerated wound healing performance. | The sustainable valorization of plastic waste into high-value biomedical materials remains a critical challenge. In this work, we report the synthesis of a polyethylene terephthalate (PET) waste-derived bis(2-hydroxyethyl) terephthalate (BHET) based copper metal-organic framework (Cu-BHET MOF) and its graphene oxide in... |
41795263 | Inflammation-targeted nanoaggregates encapsulated triptolide and hyperoside for M2 macrophage repolarization and oxidative stress reversal in rheumatoid arthritis therapy. | M1 macrophages are pivotal in rheumatoid arthritis (RA) pathogenesis, accompanied by releasing pro-inflammatory cytokines and reactive oxygen species (ROS). As a traditional anti-RA herbal ingredient, triptolide (TP) exerts potent anti-inflammatory effects via M1 macrophage modulation, but is clinically limited by poor... |
41788005 | In silico Exploration of Aegle Marmelos-Derived Compounds as Potential Inhibitors of NS5 RdRp in Japanese Encephalitis Virus. | <h4>Introduction</h4>Japanese encephalitis virus (JEV) hijacks the host cell's endoplasmic reticulum (ER) to form assembly and replication complexes during replication, leading to the production of multiple copies of JEV negative-sense and positive-sense RNA strands. The nonstructural protein NS5 RNA-dependent RNA poly... |
41785701 | Advancing metal organic frameworks screening and remediation condition optimization for removing persistent organic pollutant via integrated machine learning and theoretical calculation insights. | Metal organic frameworks (MOF) have become increasingly important for removing persistent organic pollutants (POPs). However, achieving precise and rational design of MOF based composites, as well as optimizing operational conditions for real applications, remains challenging. Many studies still rely on empirical trial... |
41782655 | An Updated Narrative Review on the Therapeutic Potential of Resveratrol in the Treatment of Cancer. | <h4>Background</h4>Cancer is a significant global health challenge, affecting millions of people every year. Overall survival rates have improved over time, but some patients exhibit treatment resistance, prompting ongoing research to find suitable and effective sensitizers. Resveratrol, a natural polyphenolic compound... |
41780770 | Trimethylamine activates the Type III Secretion System of Salmonella to enhance host cell invasion. | Epidemiological evidence has revealed that elevated plasma trimethylamine N-oxide (TMAO) levels are associated with the pathogenesis of multiple human diseases. As trimethylamine (TMA) is the key dietary precursor for TMAO biosynthesis in both mice and humans, inhibition of TMA production can effectively lower the risk... |
41780681 | Bioorthogonal Cu-MOF nanocatalyst enables GSH-triggered in situ drug synthesis for xCT-driven ferroptosis in colorectal cancer. | Despite advances in colorectal cancer (CRC) therapy, treatment outcomes remain limited by a refractory tumor microenvironment (TME) that restores redox balance and suppresses ferroptotic damage. To address this challenge, we developed HMOI, a butyrate-modulated copper metal-organic framework (Cu-MOF) designed to enable... |
41780678 | PtCu-bimetallic modified MOF nanozyme composites for alleviating acute liver injury via reactive oxygen species elimination and inflammation regulation. | Excessive reactive oxygen species (ROS) accumulation and dysregulated inflammation drive acetaminophen (APAP)-induced acute liver injury (ALI), yet the therapeutic effect of the commonly used clinical drug N-acetylcysteine (NAC) still has certain limitations at present. Here, we engineered a multifunctional nanozyme na... |
41777530 | Metal-organic framework (MOF)-embedded magnetic polysaccharide hydrogel beads for rapid and selective adsorption of malachite green and crystal violet. | This study aims to tackle water pollution caused by toxic triphenylmethane dyes-specifically malachite green (MG) and crystal violet (CV)-by developing a metal-organic framework (MOF)-based magnetic hydrogel microsphere (MMOF) using sodium alginate as the matrix. Magnetic MOF particles were embedded into the sodium alg... |
41775242 | Ligand engineering enhances Co-MOF/GF anode electrochemical degradation of atrazine. | Atrazine (ATZ), a persistent chlorinated triazine herbicide, poses significant risks to aquatic ecosystems due to its high chemical stability and endocrine-disrupting properties. Although electrochemical oxidation (EO) has shown promise for pesticide removal, the rational design of anodes capable of selectively regulat... |
41775237 | Removal of Pb<sup>2+</sup> from synthetic solutions and industrial wastewater using a magnetic hydrochar composite of spent tea leaves modified with MOF-199. | In this study, a sustainable magnetic composite adsorbent (STL-HC/MF/MOF-199) was developed from hydrochar derived from spent tea leaves and modified with manganese ferrite nanoparticles and MOF-199 for efficient Pb<sup>2+</sup> removal from aqueous solutions and real industrial wastewater. Process parameters affecting... |
41775037 | TEpiNom: A computational framework integrating population data to prioritize Plasmodium falciparum T cell epitopes. | Developing a highly effective malaria vaccine remains challenging due to Plasmodium falciparum's antigenic diversity and human leukocyte antigen (HLA) polymorphisms, which complicate antigen selection and limit immune protection. The first recommended malaria vaccine, RTS,S, provides partial, allele-specific protection... |
41772638 | Synergistic delivery of ginseng exosomes and biomimetic melanosomes via temporally controlled hydrogel microneedles restrain the pathologic triad of vitiligo. | Vitiligo pathogenesis involves progressive melanocyte loss and keratinocyte dysfunction, which are driven primarily by oxidative stress resulting from excessive ROS accumulation. We engineered a temporally controlled hydrogel microneedle system that integrates ginseng-derived exosomes (G-Exos) with biomimetic polydopam... |
41772626 | Beyond antibiotics: engineered metal nanozymes for resistance-evading antibacterial therapy. | Bacterial infections rank as the second leading cause of death globally, driven primarily by the alarming rise of multidrug-resistant (MDR) pathogens. These pathogens severely undermine the efficacy of conventional antibiotics and pose a grave threat to modern medical practice. To counter this urgent crisis, engineered... |
41772628 | Ultrasound-activated MoS₂@Fe₃O₄ nanoplatform orchestrates biofilm disruption and immune reprogramming in implant-associated infections. | Implant-associated infections (IAIs), particularly those caused by antibiotic-resistant pathogens and protected by biofilms, remain a formidable challenge in orthopedic surgery due to limited antibiotic efficacy and sustained local immunosuppression. Addressing this dual bottleneck, we report a multifunctional MoS₂@Fe₃... |
41772611 | MiR-1290 in natural killer cell derived extracellular vesicles: a pathogenic mediator of lupus nephritis and therapeutic target for th17 regulation. | Lupus nephritis (LN), a severe organ manifestation of systemic lupus erythematosus (SLE), is primarily driven by an imbalance between pathogenic Th17 cells and regulatory T (Treg) cells. We found that NK cell-derived extracellular vesicles (NK-EVs) from LN patients, but not healthy controls, exhibited a distinct miRNA ... |
41772582 | Injectable dual-drug hydrogel containing curcumin and glycyrrhizic acid for biofilm inhibition and immunomodulatory therapy in periodontitis. | <h4>Background</h4>Periodontitis is a chronic inflammatory disease characterized by excessive oxidative stress, persistent bacterial biofilms, and progressive destruction of periodontal tissues. Current clinical treatments primarily focus on controlling bacterial infection but often show limited long-term efficacy due ... |
41772577 | Self-assembled fluorescent nanosensor for ultrafast and field-deployable monitoring of herbicide fomesafen in multiple matrices. | The rising demand for ultrasensitive, field-deployable detection technologies has intensified interest in nanoprobe-based monitoring of environmental contaminants. Fomesafen (FSA), a widely used post-emergence agricultural herbicide, poses significant ecological and health risks due to its slow degradation and prolonge... |
41772430 | Effects of rutin on in vitro rumen microbial composition and urea utilization in sheep. | This in vitro study aimed to evaluate rutin as a potential feed additive for improving nitrogen metabolism in the rumen. Two experiments were conducted. In Experiment 1, the effects of rutin (0, 7.5, 10, 12.5, and 15% of substrate dry matter) on fermentation were assessed. The 12.5% rutin dose (RT3) yielded the most fa... |
41772391 | Ionic Liquids as Antibacterial and Drug Delivery Agents: How Cationic Amphiphilic Structure Controls Morphology Changes in Lipid Bilayers and Penetration Mechanism. | Ionic liquid-based technologies are promising both as antibacterial agents and in drug delivery, as they can improve drug solubility and capacity to bypass lipid bilayers while also taking advantage of ionic liquids' physical properties, such as negligible vapor pressure and stability. In both applications, it is imper... |
41772191 | Rational design of rigid mRNA folding architecture to enhance intracellular processing and protein production. | The application of messenger RNA (mRNA) beyond infectious diseases is challenged by inefficient protein production. Whereas the engineering of secondary mRNA structures has been shown to increase mRNA half-life, it remains unclear whether tertiary mRNA structures influence therapeutic efficacy. Here we develop a metal-... |
41772172 | A state-switchable TADF macrocycle for multi-analyte sensing and hydrogen gas-driven emission enhancement. | Photochemical sensing demands systems that adjust their optical properties without altering chromophore structure. Here, we report CPCQ, a thermally activated delayed fluorescence (TADF)-active macrocycle, as a responsive platform for optical sensing. CPCQ shows a photoluminescence quantum yield (PLQY) of 78%, a delaye... |
41772112 | Plant-based production of virus-like particles from hepatitis C virus. | <h4>Main conclusion</h4>Virus-like particles (VLP) from hepatitis C virus were successfully produced in Nicotiana benthamiana plants for the first time, by co-expressing three viral proteins (Core, E1 and E2) in a polycistron-like arrangement. Hepatitis C virus (HCV) remains a global health challenge, underscoring the ... |
41772090 | RNA-specific local translation is patterned by condensates for multinucleate cell growth. | Coordination between growth and nuclear division is a common cell feature. In some syncytia, nuclei divide asynchronously throughout the cell but growth occurs only at discrete locations, raising the question how the processes are locally regulated and globally coordinated. In the syncytial fungus Ashbya gossypii, both... |
41772083 | Structure-guided design of a PfCyRPA-based vaccine against blood-stage malaria. | Effective vaccines against malaria are urgently required. All components of the PfPCRCR complex are essential for erythrocyte invasion by Plasmodium falciparum and are potential vaccine immunogens against blood-stage malaria. Of these, PfRH5 has progressed furthest in clinical development, while PfCyRPA also induces pa... |
41771920 | Supramolecular coiled-coil peptide platform for site-specific antibody drug conjugate engineering. | Antibody conjugates play a central role across multiple healthcare sectors with a prime example being antibody-drug conjugates (ADCs). Although widely used lysine and hinge cysteine conjugation methods yield products, the lack of site-specificity and spatial control along with the highly heterogeneous composition are s... |
41771907 | Image-to-molecule benchmarking dataset with fractal pattern and hierarchical morphology recognition. | The unique phenomenon of high morphological diversity of quaternary phosphonium salts (QPSs) has been observed via electron and optical microscopy. The molecular structure of the QPSs, which differ by one methylene group, was shown to be reflected in the microstructure of the crystallized droplets. Here, we describe ex... |
41771908 | ReactionSeek: LLM-powered literature data mining and knowledge discovery in organic synthesis. | The application of artificial intelligence (AI) to chemical discovery is critically hindered by the inaccessibility of data locked within unstructured scientific literature. Existing data acquisition methods are often manual, limited in scope, or require extensive custom software development, impeding progress in lever... |
41771899 | Reversible surface modifications of functional proteins for accelerated cytosolic delivery via cell-penetrating peptide clusters. | A long-standing goal in biomedical research is to label and manipulate intracellular targets, which could be achieved through the cytosolic delivery of exogenous functional proteins. The development of Tat clusters has advanced the nontoxic intracellular delivery of functional antibodies at low concentrations, but the ... |
41771900 | Umami induces pulmonary epithelial senescence via L-glutamic acid-triggered minority MOMP. | Although cellular senescence in pulmonary epithelial cells is a recognized driver of chronic lung diseases, the role of dietary factors in initiating this process remains poorly defined. Here, we identify monosodium glutamate (MSG), the primary source of umami taste, as a trigger of a novel dietary-lung axis. We demons... |
41771892 | Persistent semiquinone radicals enable efficient near-infrared-driven H<sub>2</sub>O<sub>2</sub> photosynthesis. | Photosynthesis of H<sub>2</sub>O<sub>2</sub> under sunlight is a sustainable method; however, most developed photocatalysts utilize limited near-infrared light, which accounts for 52% of the solar spectrum. In typical near-infrared photocatalysts, excited electrons fall into low-energy sub-gap states, reducing the driv... |
41771875 | Aptamer-functionalized magnetic beads combined with hybridization chain reaction for detection of Bacillus cereus. | Based on the specific aptamer-functionalized magnetic beads and the hybrid chain reaction (HCR), a rapid detection method for Bacillus cereus was established. B. cereus competes with carboxylfluorescein-labeled cDNA (FAM-cDNA) to bind to biotin-labeled aptamer fixed on streptavidin magnetic beads. After magnetic separa... |
41771865 | Generation of multitissue cell-cultivated meat via multidirectional differentiation of stable porcine epiblast stem cells. | Cell-cultivated meat has emerged as an alternative approach for sustainable protein production, but replicating the texture and complex composition of conventional meat remains a critical challenge. Here, we developed an efficient approach to produce multitissue engineered meat by leveraging a serum- and animal-compone... |
41771864 | Knittable, thermally insulating, and sustainable aerogel fibers enabled by ion-mediated hierarchical assembly. | Aerogel fibers (AFs), while promising for personal thermal management, are constrained by an inherent trade-off between mechanical robustness and thermal insulating performance. To resolve this mechanical-thermal coupling issue, we propose an ion-mediated attenuated Coulombic assembly of recyclable heterocyclic aramid ... |
41771857 | Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa. | Bacterial proteasomal activator (Bpa) is a regulatory particle of the Mycobacterium tuberculosis proteasome that facilitates the recruitment of substrates and their subsequent degradation by the 20S core particle. Substrate-bound structures of Bpa are unavailable, leaving its recruitment mechanism incompletely understo... |
41771788 | Tuning of Electron-Donating Metal-Organic Frameworks toward High-Performance Triboelectric Nanogenerators for Self-Powered Shear Sensing. | Triboelectric nanogenerators (TENGs), which convert mechanical energy into electrical signals, have emerged as apromising platform for self-powered motion sensing. However, the development of high-sensitivity TENG sensors remains limited by the availability of tunable and efficient tribo-positive materials, which are e... |
41771535 | Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation. | Coenzyme A (CoA) biosynthesis is controlled by the four isoforms of the rate-limiting enzyme pantothenate kinase (PANK), whose tissue expression and subcellular localization regulate CoA homeostasis. Pantazines are positive allosteric modulators of PANK that increase cellular CoA levels by disrupting feedback inhibitio... |
41771532 | Fluorescence Detection of Alpha-Synuclein Aggregates in the Gut Using a Peptide Probe. | Parkinson's disease (PD) is diagnosed clinically by motor symptoms, with no clinical molecular diagnostic test currently available. By the time motor symptoms manifest, significant irreversible neurodegeneration would have already occurred, limiting the effectiveness of the therapies. Recent identification of pathologi... |
41771291 | Interplay of Quantum Size Effect and Tensile Strain on Surface Morphology of β-Sn(100) Islands. | The quantum size effect (QSE) and strain effect are two key factors influencing the surface morphology of thin films, which can increase film surface roughness through QSE-induced thickness oscillation and strain-induced island formation, respectively. Surface roughness usually manifests in the early stages of film gro... |
41771050 | Formulation of an Efficient O(<i>M</i><sup>4</sup>)-Scaling Explicitly Correlated MP2-F12 Correction by Combining Numerical Quadrature with Density Fitting and CABS-RI. | We present a novel approach that combines numerical quadrature with density fitting and CABS-RI for the evaluation of exchange-type intermediates in RI-MP2-F12 theory, rigorously reducing the formal and practical scaling of the total correction from O(M5) to O(M4). Our new hybrid NQ/DF/CABS-RI ansatz is based directly ... |
41771045 | Structural Analysis of Curium, Promethium, and Early Lanthanides Using 2,2':6',2″-Terpyridine in the Presence of Acid. | Trivalent lanthanides and actinides are difficult to separate, often relying on subtle differences in bonding between the 4<i>f</i>- and 5<i>f</i>-orbitals. However, trivalent Cm poses additional complexity owing to its half-filled 5f<sup>7</sup> shell. This configuration causes Cm to have very similar properties to se... |
41771044 | Hierarchical Assembly of Fluorinated BODIPY-Based Nanoribbons for Highly Efficient Metal-Free Photocatalytic Hydrogen Production. | Self-assembly provides the structural basis for natural photosynthesis, coordinating light-harvesting, energy transfer, and catalysis. However, achieving precise control over assemblies in artificial systems to realize efficient and stable metal-free photocatalysis remains a formidable challenge. Herein, we report the ... |
41770896 | Engineering Carbonic Anhydrase Mimics via Metal Ion Doping: Tailoring the Structure and Catalytic Properties of a 2-Aminoimidazole-Based MOF. | Metal-organic frameworks (MOFs) show great promise as carbonic anhydrase (CA) mimics due to their high surface area, tunable porosity, and abundant active sites. This study enhances a reported 2-aminoimidazole-based Zn-MOF by incorporating Co<sup>2+</sup>, Ni<sup>2+</sup>, or Cu<sup>2+</sup> via in situ doping, systema... |
41770891 | Biomass-Derived Conductive Hydrogel-Based Electronic-Skin Patch for Integrated Wearable Bioelectronics and Real-Time Wound-Status Monitoring and Treatment. | Conductive hydrogel-based electronic-skin (e-skin) patches represent an emerging category of smart wound dressings, facilitating innovative approaches to chronic wound repair and real-time monitoring. Despite their advantages in biocompatibility and exudate management, current hydrogel patches frequently suffer from li... |
41770706 | Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels. | Natural anisotropic tissues, such as tendons and cartilages, achieve remarkable mechanical properties and various biofunctions through oriented hierarchical structures. Inspired from organisms, we develop a synergistic molecular and structural engineering technique based on the thermodynamically reversible reconfigurat... |
41770527 | Post-Synthetic Functionalization of Porous Materials (MOFs and Silica) with Tetrapyrrole Macrocycles as Antiviral Materials against Coronaviruses and Hepatitis C Virus. | Mesoporous silica SBA-15 and two Metal-Organic Frameworks (MOFs), UiO-66(Zr)-NH<sub>2</sub> and MIL-125(Ti)-NH<sub>2</sub>, were functionalized with tetrapyrrole macrocycles (TpM), two chlorin, and two porphyrin molecules with a simple coupling reaction, creating a strong covalent amide bond. Next, their antiviral acti... |
41770426 | Nature meets machine: the AI renaissance in natural product drug discovery. | Natural products (NPs) have long served as a cornerstone of drug discovery, yielding landmark therapeutics such as paclitaxel and artemisinin and providing sustained access to biologically relevant chemical space. Despite this legacy, NP-based discovery has gradually declined with the rise of synthetic chemistry and hi... |
41770377 | CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond. | CAR-T cell therapy, which uses endogenous T cells engineered to target specific cancer antigens, is one of the most promising recent developments in the treatment of hematologic malignancies in both children and adults. CAR-T cells have shown tremendous success in treating B-cell lymphoma, acute lymphoblastic leukemia,... |
41770257 | Design Concept of Metal Sulfide Photocatalyst for Efficient Photocatalytic Hydrogen Evolution. | Metal sulfide (MS) photocatalysts hold unique features of narrow-bandgap range, high light absorption coefficient, and suitable band structures, offering significant potential for efficient visible-light photocatalytic hydrogen evolution (PHE) via water splitting. However, the low electronic dimensionality of the tradi... |
41770203 | Stereocontrolled Synthesis of Chiral [2]Catenanes by Coordination-Driven Self-Assembly. | Chiral catenanes hold substantial research significance due to their potential applications in stereoselective catalysis, sensing, and chiroptical switching. However, achieving stereocontrolled synthesis of enantiopure supramolecular catenanes with crystallographically characterized structures remains challenging. Here... |
41770062 | CO<sub>2</sub> Capture from Flue Gas: A High-Fidelity Force Field and Machine Learning Framework for Adsorbent Discovery. | CO<sub>2</sub> from flue gas is central to mitigating fossil-fuel-derived emissions, where adsorbent performance directly dictates process energy efficiency and process cost. Although machine learning (ML) has emerged as a powerful tool for accelerating adsorbent discovery, its predictive accuracy is fundamentally limi... |
41769994 | Challenges in developing broad-spectrum viral attachment inhibitors targeting heparan sulfates and sialic acids. | Many distinct viruses exploit cell surface glycans, particularly heparan sulfates and sialic acids, as initial attachment factors to facilitate entry into host cells. Because these interactions are highly conserved across diverse viral families, they have long been viewed as attractive targets for the development of br... |
41769998 | Discovery and functional characterization of endoglucanases from <i>Coptotermes formosanus</i> with enhanced cellulose hydrolysis via yeast surface display. | Microbial cellulose degradation offers a sustainable route to convert agricultural and forestry residues into value-added chemicals. Here, we report the discovery and functional characterization of eight novel endoglucanases (CTEG1 and CTEG3-CTEG9) from a <i>Coptotermes formosanus</i> cDNA library and heterologously ex... |
41769918 | Decoding Interfacial Evolution of Aluminum Anode and Constructing Multifunctional Layers toward Ultra-Long Cycle Stability. | Understanding the dynamic evolution of the aluminum anode interface in ionic liquid electrolytes is crucial for the large-scale application of rechargeable aluminum batteries (RABs). Herein, we use a series of advanced in situ characterizations to reveal a dendrite-to-corrosion transition, demonstrating that imidazoliu... |
41769896 | Spherical Nucleic Acids: Turning Synthetic Advances and Fundamental Discovery into Translational Breakthroughs in Chemistry, Materials Development, Biology, and Medicine. | ConspectusEarly research in nanoscience and nanotechnology focused on gaining synthetic control over the size, shape, and composition of nanostructures, as well as exploring their fundamental properties. Over the past few decades, these capabilities have become increasingly sophisticated. Today, we have well-establishe... |
41769804 | Pillararene-Catalyzed Kemp Elimination: High Efficiency through Orthogonal Self-Sorting Binding and Ion Modulation. | Enhancing the efficiency and versatility of supramolecular catalysis remains a central research goal. Water-soluble pillar[6]arenes (H1), per-substituted with quaternary ammonium groups, catalyze the aqueous-phase Kemp elimination of 1,2-benzisoxazole (R1), achieving <i>k</i><sub>cat</sub>/<i>k</i><sub>uncat</sub> rati... |
41766690 | Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C. | KRAS G12C is one of the most prevalent oncogenic mutations in nonsmall cell lung cancer. Herein we describe the discovery and optimization of divarasib (GDC-6036), an orally available, highly potent, and selective covalent KRAS G12C inhibitor. We demonstrate a significant noncovalent binding component of divarasib that... |
41766614 | Single-Molecule All-In-One (SMALL) Dendritic Dots for Precise Cancer Theranostics. | Multifunctional nanoparticles with diverse cargos have been extensively developed for efficient cancer theranostics. However, the requirement of additional components would result in stochastic functionalization, interfering with the precise structure and desired characteristics. Thus, it is requisite and challenging t... |
41766582 | Medicinal chemistry approaches for dual inhibition of amyloid-β and tau aggregation in Alzheimer's disease. | Proteinopathies play a complex interplay in the pathogenesis of multifactorial neurological disorders. In Alzheimer's disease (AD), the extracellular deposition of amyloid-β (Aβ) plaques and intracellular accumulation of hyperphosphorylated tau into neurofibrillary tangles are the two principal pathological hallmarks. ... |
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