id stringlengths 4 8 | title stringlengths 1 642 | abstract stringlengths 50 17.9k |
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41836537 | Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>(O<sub>2</sub>C-<i>t-</i>Bu)<sub>12</sub> precursor uncovers how modulators govern supersaturation, nucleation, and growth of UiO-66 nanocrystals. | Pure Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>(O<sub>2</sub>C-<i>t</i>-Bu)<sub>12</sub> (Zr<sub>6</sub>-Pivalate) is used to prepare UiO-66 nanocrystals (<i>d</i> = 19-186 nm, <i>σ</i> = 10-30%) in a hot injection synthesis. <i>In situ</i> dynamic light scattering (DLS) measurements show that nanocrystal formation is... |
41833120 | Analysis of the immunomodulatory effects of Honeysuckle leaf polysaccharides on cherry valley ducks based on transcriptomic techniques. | This study aimed to optimize the extraction process of Honeysuckle leaf polysaccharides (HLP) and investigate their regulatory effects on immune function, as well as the underlying molecular mechanisms, in Cherry valley meat ducks. Using dried Honeysuckle leaves as the raw material, the water extraction-alcohol precipi... |
41829134 | Using Integrated Microbiome-Metabolome-Genome Axis Data to Elucidate the Mechanism by Which Polyphenol Content in the Extract from <i>C. osmantha</i> Leaves (PECOL) Regulates Broiler Flavor. | The quality and flavor of chicken meat are the key factors that influence consumers' purchase decisions. Recent studies have demonstrated that polyphenol can modulate meat quality. In this study, an integrated multi-omics approach was utilized to systematically identify the regulatory effect of dietary supplementation ... |
41829146 | Strategically Designed Coaxial Electrospun Nanofibers of Polylactic Acid/Glycerol Monolaurate Hydroxypropyl-<i>γ</i>-Cyclodextrin Inclusion Compound with Sustained Release for Active Food Packaging. | Post-harvest deterioration in strawberries is an urgent and critical issue that requires significant attention. Glycerol monolaurate (GML), a broad-spectrum food-grade antimicrobial agent, faces limited applicability due to its poor water solubility. In this study, a confined encapsulation strategy was employed to enca... |
41829128 | Flavor Formation in Goat Meat: A Lipid-Centric Comparative Study of High-Altitude and Low-Altitude Breeds. | Flavor is a pivotal determinant of goat meat quality, influenced by multiple factors. This study investigated flavor formation from a lipid perspective by comparing two distinct breeds at two years old and fed the same diet: the high-altitude Xizang goat (XG; <i>n</i> = 6, 26.23 ± 0.72 kg), renowned for its unique meat... |
41828841 | Trimetallic Zeolitic Imidazolate Framework-Derived CoNiO<sub>2</sub>/NiCo<sub>2</sub>O<sub>4</sub>/NiFe<sub>2</sub>O<sub>4</sub> Hierarchical Architecture: Unveiling Multi-Component Synergism for Ultrahigh-Capacity and Highly Stable Lithium Storage. | Transition metal oxides (TMOs) have been recognized as highly prospective anode materials for lithium-ion batteries (LIBs) due to their low cost, high capacity, and distinctive lithiation mechanisms. Nevertheless, their practical adoption is constrained by significant volume changes during lithiation/delithiation, infe... |
41827765 | Protein Nanocarriers: Targeted Theranostics for Cancer Treatment and Imaging. | Protein-based nanocarriers have gained considerable attention for targeted cancer theranostic applications due to their inherent biocompatibility, biodegradability, and facile functionalisation. In addition, some of their properties, such as self-assembling nature, low immunogenicity (if species matched), molecular rec... |
41823774 | A Dual Quantum Dot Fluorescent Probe for Time-Resolved Chemometric Detection of Chloramphenicolin Pharmaceuticals. | Dual-emission photoluminescence (PL) nanoprobes provide improved analytical performance to develop a reliable and sensitive sensing platform for quantifying chloramphenicol in pharmaceutical samples, thereby ensuring therapeutic efficacy and patient safety. In this work, a dual-emission PL sensing platform combining ca... |
41816768 | NaCl-mediated gluten protein-wheat starch interaction changes in high-, medium- and low-gluten model doughs during heating stage. | This study investigated how NaCl affects gluten-starch interactions in model doughs with varying gluten contents during heating. Results showed adding NaCl weakened the hydrogen bonds between proteins in the initial dough mixing (C1) → protein weakening (C2) stage and enhanced hydrogen bond interaction in the C2 → star... |
41810126 | Multi-Technology Empowers Dissolving Microneedles: A Novel Strategy in Rheumatoid Arthritis. | Rheumatoid arthritis (RA) is a systemic autoimmune disease associated with chronic inflammation. Current clinical management is confronted with multiple challenges, such as suboptimal drug bioavailability, insufficient joint targeting, and poor patient compliance, which critically limit therapeutic efficacy. Dissolving... |
41810016 | Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy. | Mitophagy is a self-protection mechanism for cells to eliminate dysfunctional mitochondria, and maintain mitochondrial homeostasis. Thus, precisely inducing mitophagy represents a promising strategy for acute lung injury (ALI) immunotherapy. Here, the mitochondrial targeted palladium loaded siraitia grosvenorii derived... |
41809095 | Dual-function thermoresponsive antibiotic-loaded hydrogel with antimicrobial and osteogenic properties for implant-related infection control. | Implant-related infections demand advanced biomaterials capable of delivering localized, sustained antimicrobial activity while supporting tissue repair. Here, we present an engineered thermoresponsive hydrogel based on poly(N-vinylcaprolactam) (PNVCL), designed as a dual-function platform that enables temperature-trig... |
41802403 | Single-atom-enhanced molecularly imprinted electrochemical sensor with Fe<sub>3</sub>O<sub>4</sub>-Ru<sub>1</sub>@NC nanocatalysts for ultrasensitive detection of 5-heneicosylresorcinol in whole wheat food. | Accurate quantification of alkylresorcinols is crucial for evaluating the nutritional quality and authenticity of whole wheat products, yet current analytical methods often lack sensitivity and practicality. In this study, we developed a novel electrochemical sensor that integrates single-atom catalysis (Fe<sub>3</sub>... |
41800127 | Potential of Vγ9Vδ2T cells in tuberculosis: integration of innate and adaptive immunity for vaccine development. | Tuberculosis (TB) is a chronic infectious disease caused by <i>Mycobacterium tuberculosis</i> that poses major global health challenges. The Bacillus Calmette-Guérin (BCG) vaccine provides only limited protection against TB in adults and the current therapeutic regimens for TB are constrained by prolonged treatment cyc... |
41799855 | Inhibitory Effect of <i>Curcuma xanthorrhiza</i> Extract Against SARS-CoV-2 D614G Virus-Like Particle (VLP): Implications for COVID-19 Therapy Development. | <i>Curcuma xanthorrhiza</i>, a commonly used Indonesian medicinal plant, has been widely utilized in traditional remedies, yet its antiviral potential against SARS-CoV-2 remains poorly defined. The current study was aimed at investigating the effect of <i>C. xanthorrhiza</i> ethanol extract on inhibiting viral entry th... |
41797163 | Ultrasensitive fluorescent sensing platform based on N, Zr co-doped carbon dots: Cr(VI) detection and solid-state application enabled by ZIF-8 encapsulation. | By modulating the nitrogen precursor (ethylenediamine vs. urea), we tailored the ratio of graphitic N to amino N in N, Zr co-doped carbon dots, thereby enabling the construction of an ultrasensitive fluorescent probe for Cr(VI) detection with an exceptionally low detection limit of 2.208 μM. Furthermore, real-time fluo... |
41797130 | Novel aminophosphoryl hybridization of natural berberine and heterocyclic azoles with large potential to combat global increasing bacterial resistance. | Unique aminophosphoryl hybridization of natural berberine with heterocyclic azoles was conducted to access novel antibacterial agents with large potential to combat deadly bacterial resistance. Some prepared berberine conjugates effectively inhibited the growth of tested bacteria, particularly, methyloxazolyl aminosulf... |
41795257 | Mechanistic insights into Cyclodextrin-mediated modulation of curcumin-BSA interactions: Integrated spectroscopic and molecular modeling. | Cyclodextrins (CDs) have shown significant efficacy in enhancing the aqueous solubility and chemical stability of curcumin (CUR). However, their impact on the interaction between serum albumin and CUR remains inadequately understood, despite the potential implications for CUR's tissue distribution, metabolism, and bioa... |
41791710 | Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition. | A fraction of the eukaryotic genome is transcriptionally silenced in the form of facultative heterochromatin, characterized by the histone H3 lysine 27 tri-methyl (H3K27me3) modification. The cell-specific and dynamic nature of H3K27me3-marked chromatin is centrally regulated by the catalytic function of the polycomb r... |
41791706 | Insights into the recognition of cyclic α-(1→6)-glucan by a solute-binding protein of an ABC transporter from Tepidibacillus decaturensis. | ABC transporters facilitate the translocation of various substrates across biological membranes. In prokaryotic ABC importers, the solute-binding protein, which selectively binds to a ligand, is incorporated into the functional complex. Cycloisomaltooligosaccharides (CIs) are produced from α-(1→6)-glucan by CI glucanot... |
41791536 | Engineering MOF-enzyme affinity: Surface-functionalized ZrBTB-NH<sub>2</sub> for high-performance immobilization of cytochrome c. | Enzyme immobilization on metal-organic frameworks (MOFs) offers a promising strategy to enhance biocatalytic stability and reusability, yet achieving high loading capacity while maintaining enzymatic activity remains challenging. Here, we report the rational design of functionalized zirconium-based MOFs (ZrBTB-X) for t... |
41789301 | Multigated Photochromic Materials: Mechanism, Progress, and Application. | Photoresponsive materials offer unique opportunities for advanced technologies by enabling their precise, noncontact remote control and converting light energy into well-defined changes in structure and function. Among them, multigated photochromic systems have emerged as a transformative frontier, overcoming constrain... |
41789251 | A New Kinetic-Mechanistic Approach Towards Spectrophotometric Bioanalysis of 2-Phenylethylamine as a Sympathomimetic Agent Using Sodium Isopropyl Xanthate. | 2-Phenylethylamine (2-PEA), an aromatic biogenic amine, demonstrates significant physiological and toxicological effects on human health. A variety of conventional methods have been widely used for the determination of 2-PEA. However, the necessity of complex sample preparation and high cost of instrumentation may pose... |
41788857 | Versatile Nanotherapeutics for Enhancing Sonodynamic Therapy/Chemotherapy of Thyroid Cancer through Remodeling Tumor Microenvironment and Synergistic Reactive Oxygen Species Augment. | Anaplastic thyroid carcinoma (ATC), as the most malignant pathological type, is prone to local invasion and even distant metastasis with a poor prognosis and a high recurrence rate. Herein, we developed an iron-based metal organic framework (FL@M) as an effective sonosensitizer and biomimetic nanocarrier through the in... |
41788374 | Functionalized biochar-metal oxide nanocomposites for the catalytic degradation of recalcitrant pollutants in wastewater treatment. | Modified biochar (BC) nano-compounds are very promising candidates for the accelerated degradation of reoccurring contaminants in wastewater treatment. The surface activity, structural repair, and dopant chemistry of biochar determine its adsorption ability and catalytic behaviour. Metal oxides such as Fe<sub>3</sub>O<... |
41788367 | NMR spectroscopic and computational analysis of <i>E</i>/<i>Z</i> isomerism in imines derived from isatin. | Isatin reacts with primary amines to yield mixtures of <i>E</i> and <i>Z</i> imine stereoisomers. This study provides a detailed structural analysis of selected isatin-derived imines using <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, complemented by computational methods. The <i>E</i>/<i>Z</i> ratio in solution i... |
41782412 | Fe<sup>2+</sup>- Induced Activation of Single and Dual Metal Site-Lattice Oxygen Mechanism in Fe Rich NiFe-LDHs for Oxygen Evolution Reaction. | Developing a durable and efficient oxygen evolution reaction (OER) catalyst without noble metals is essential for the economical and sustainable production of hydrogen by alkaline water electrolysis. Recent studies have advocated triggering the lattice oxygen mechanism (LOM) to reduce the overpotential of catalysis and... |
41782397 | Antigen anisotropy: The overlooked geometric determinant of vaccine immunogenicity and fidelity. | Antigen anisotropy, the directional dependence of protein conformation, epitope exposure, and conformational dynamics, is an under-appreciated determinant of vaccine immunogenicity. Preserving this geometric fidelity may influence outcomes such as neutralization breadth, affinity maturation, and B/T-cell response quali... |
41782210 | Unlocking plant abiotic stress resilience through biostimulants and omics-driven innovations. | Frequent changes in global climate enhance environmental cues, threaten agricultural systems, which jeopardizes food security, and impair the achievements of the United Nations Sustainable Development Goal 2 "Zero Hunger". To achieve a sustainable path, use of biostimulants represents a new strategy to enhance plant re... |
41782011 | Bacteria and phage consortia modulate cecal SCFA production and host metabolism to enhance feed efficiency in ducks. | <h4>Background</h4>The gut microbiota influences poultry health, nutrition, feed efficiency (FE), and overall productivity. However, the relationship between gut microbes, including bacteria and phages, and FE in ducks remains underexplored. To address this, we integrated cecal 16S amplicon, metagenome, microbiota-deri... |
41781992 | Targeting engineered cell membrane camouflaged gallic acid-cerium nanozyme for intercepting the inflammation-free radical vicious cycle in atherosclerosis. | Atherosclerotic plaques are characterized by oxidative stress and inflammatory responses, which amplify each other in a vicious cycle, leading to progressive plaque destabilization and ultimately serious cardiovascular events. Therefore, the development of nanoformulations with synergistically enhanced anti-inflammator... |
41781813 | Self-Powered Ultraviolet Photodetectors Enabled by Multisite Bonding at Imidazolate Framework-Polyethylenimine Interfaces. | Self-powered ultraviolet (UV) photodetectors are attractive for energy-autonomous sensing, but achieving high detectivity with metal-organic frameworks remains challenging due to poor film morphology and leakage currents. Here, we fabricate a vertical photodiode (FTO/ZIF-8@PEI/PEDOT:PSS/Au) using a ZIF-8@polyethylenimi... |
41781697 | Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing. | Cytotoxic T lymphocytes (CTLs) eliminate target cells by forming immunological synapses and releasing effector molecules, including interferon gamma (IFNγ). However, how IFNγ contributes to cytotoxicity remains unclear. Here, we identify a subset of IFNγ stored within granzyme B⁺ cytotoxic granules (CGs) in activated m... |
41781696 | Oncolytic virus M1 reinvigorates CD8<sup>+</sup> T-cell immunity against glioblastoma through B-cell-dependent antigen cross-presentation in the spleen. | Glioblastoma multiforme (GBM) is a lethal primary brain cancer with limited treatment options. Systemic and local immunosuppression induced by GBMs contributes to malignancy aggressiveness and resistance to immune checkpoint blockade (ICB) therapy. Herein, we demonstrated that a novel oncolytic virus, M1 (OVM), reverse... |
41781680 | Mechanistic insights into the structure and function of the RecA C-terminal tail. | Bacterial RecA protein oligomerizes on single-stranded DNA (ssDNA) in the presence of ATP to form an active filament, RecA*, which is essential for homologous recombination and the activation of bacterial DNA damage response (SOS response). Despite extensive studies on the structure and function of RecA and RecA*, the ... |
41781659 | An acetylation-dependent switch underlies host disease tolerance during streptococcal infection. | Building on our finding that Streptococcus pyogenes pyruvate dehydrogenase (PDH) suppresses host disease tolerance (DT) via short-chain fatty acid (SCFA)-mediated modulation of host acetyl-CoA and IL-10 levels, we characterize the global transcriptomic and epigenetic mechanisms underlying this immunometabolic manipulat... |
41781575 | Multi-epitope vaccine against nucleoprotein and envelopment polyprotein of Batai orthobunyavirus using molecular docking and molecular dynamics studies. | Batai orthobunyavirus (BATV) is a mosquito-borne orthobunyavirus that affects both humans and animals, and currently no licensed vaccine is available. The aim of this study was to design a multi-epitope vaccine candidate against BATV using a computational vaccinology pipeline. Predicted B-cell and T-cell epitopes from ... |
41781405 | Epigenetic and transcriptional profiling of secondary hair follicle stem cells during cashmere growth. | Cashmere grows from secondary hair follicles (SHFs), which serve as abundant reservoirs of synchronized stem cells responsible for the cyclical regeneration of cashmere. To investigate the epigenetic regulation of this process, we performed ChIP-seq targeting four key histone marks-H3K4me3, H3K27me3, H3K36me3 and H3K79... |
41781388 | Inhibiting Mrt4-rRNA interaction with fumaramidmycin-based derivatives as an antifungal strategy. | The rise of drug resistance and limitations of current antifungal treatments highlight the urgent need for innovative antifungal strategies. Here we present the development of cis-fumaramidmycin-derived analogs inhibiting the interactions of ribosome assembly factor Mrt4 with rRNA to combat fungal infections. Through a... |
41781374 | Osteoarthritis: molecular pathogenesis and potential therapeutic options. | Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate in halting disease progression or providing effective pain relief, highlighting u... |
41781274 | Epicatechin-Diarylboronate Aggregates with Inhibited Auto-oxidation and Stable Antioxidant Activity: Structural Modification and Binding Thermodynamics. | Improving the stability of catechins against autoxidation and simultaneously exerting their biological activity to scavenge reactive oxygen species (ROS) are essential for achieving their efficient utilization in healthcare and drug therapy. Focusing on this important objective, a feasible strategy for modifying catech... |
41781267 | Binding Characteristics and Functional Analysis of Odorant-Binding Protein 17 in the Rice Water Weevil (<i>Lissorhoptrus oryzophilus</i>) with Host Volatiles. | Odorant binding proteins (OBPs) are essential for insect olfaction. <i>Lissorhoptrus oryzophilus</i> (Coleoptera: Curculionidae), known as the rice water weevil, is a destructive pest of rice. In this study, rice volatiles were analyzed by gas chromatography-mass spectrometry (GC-MS), and ten rice volatiles were identi... |
41781188 | Intracellular Dynamic Supramolecular Polymerization to Elicit Tumor Pyroptosis. | Dynamic construction of macrostructures within living systems via supramolecular polymerization holds great potential for directing cellular fates. Current systems, however, are predominantly irreversible and often employ peptide- or nucleic-acid-based monomers vulnerable to enzymatic degradation. Herein, we present a ... |
41781017 | Antibody therapeutics with high affinity for FcγRs exacerbate anaphylaxis via FcγR-mediated capture by tumor-associated myeloid cells. | <h4>Background</h4>Antibody therapeutics have revolutionized cancer treatment, but their use is increasingly associated with adverse events. Among these, anaphylaxis is particularly concerning due to its severity and unpredictability. Our previous studies demonstrated that repeated administration of anti-programmed dea... |
41780913 | Enhanced Green Hydrogen Generation via Photocatalytic Water Splitting Using V-Doped Ti-Squarate MOFs. | Herein, defect engineering strategies were applied to enhance the photocatalytic activity of squarate-based MOFs (IEF-11) for green hydrogen generation via water splitting. The textural properties of pristine IEF-11(Ti) were significantly improved using microwave (MW)-assisted synthesis, leading to a four-fold increase... |
41780383 | Enhancing methane production in anaerobic digestion of food waste by Fe-MOF and Fe-MOF-derived carbon composites: Insights into properties, multi-omics analyses, and mechanisms. | In this work, Fe-MOF and Fe-MOF-derived carbon composites (Fe-MDCs) derived at 300, 500, and 700 °C were first applied in anaerobic digestion to achieve efficient renewable energy production from food waste. The enhancement mechanism of methane yield was further explored using metagenomic and metaproteomic analysis. Th... |
41779981 | Izalontamab Brengitecan in Locally Advanced or Metastatic Non-Small Cell Lung Cancer With Actionable Genomic Alterations Outside of Classical <i>EGFR</i> Mutations: A Phase Ib Study. | <h4>Purpose</h4>To evaluate the safety and efficacy of izalontamab brengitecan (iza-bren) in patients with non-small cell lung cancer (NSCLC) harboring actionable genomic alterations (GAs) outside of classical epidermal growth factor receptor (<i>EGFR</i>) mutations.<h4>Methods</h4>Eligible patients had locally advance... |
41779970 | Extending BigSMILES to Include Topological Bonds. | Machine-readable line notations such as SMILES are rapidly gaining popularity as a means of storing, searching, and analyzing chemical information. Within the SMILES framework, BigSMILES was developed to represent the stochastic connectivity characteristics of polymers. More recently, noncovalent BigSMILES extended the... |
41779967 | Multiscale Insights into the Genesis of Pickering Emulsions: Nanomixing and Interfacial Design of Surface-Active Silica Particles. | Pickering emulsions─liquid-liquid dispersions stabilized by solid particles─offer a sustainable route for oil extraction, fine chemistry, organic synthesis, and catalysis applications. The formulation of Pickering emulsions involves surface-active particles that selectively adsorb at the interface between immiscible li... |
41779945 | Surfactant-Assisted Morphology Tuning of Ultramicroporous Metal-Organic Frameworks for Efficient Olefine/Paraffin Sieving. | Morphology control is a powerful approach to tailor the properties of metal-organic frameworks (MOFs) for separation, catalysis, sensing, and photonics applications. However, previous efforts have primarily focused on microporous systems with pore sizes beyond typical gas dimension thresholds (>0.5 nm); the structural ... |
41779943 | Coarse-Grained Model of the Sodium Dodecyl Sulfate Anionic Surfactant Based on the MDPD-Martini Force Field. | The sodium dodecyl sulfate (SDS) surfactant is widely used in various applications, such as household products (e.g., shampoos, toothpaste, detergents, and cleaning products) and food manufacturing (e.g., emulsifiers). To investigate its properties via computer simulation, various models have been developed, including ... |
41779923 | Modulating Ce<sub>6</sub> Nodes of Ce-MOFs for Boosting the Photocatalytic Decarboxylative Oxygenation of Carboxylic Acids. | Tuning the microenvironments of metal nodes in metal-organic frameworks (MOFs) is crucial for optimizing their photocatalytic performance, but it remains challenging. Herein, we report a benzoic acid (BA) modulator-assisted strategy to regulate the coordination microenvironment of Ce<sub>6</sub> nodes in Ce-based MOFs ... |
41779922 | Grain-Size Engineering in Vapor-Deposited ZIF-8 MOF: Low-Leakage Low-<i>k</i> Films with Enhanced Breakdown Field. | The integration of low-<i>k</i> dielectrics into advanced logic and memory technologies requires materials that combine low permittivity with high electrical reliability and plasma robustness. Zeolitic imidazolate framework-8 (ZIF-8) has emerged as a promising candidate for back-end interlayer dielectrics due to its va... |
41779829 | Copper-Based MOF Derivative with Enhanced Electrocatalytic Activity for Highly Sensitive and Ultrafast Detection of Salivary Glucose. | Currently, invasive blood-testing methods that are widely employed for diabetes monitoring present issues including discomfort, infection risks, and delayed wound healing, which lead to poor patient compliance, creating a demand for noninvasive testing methods, including saliva-based testing. However, the implementatio... |
41779785 | Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates. | FicD regulates Unfolded Protein Response (UPR) through reversible AMPylation and deAMPylation of BiP, an HSP70 chaperone and master regulator of the UPR. FicD activity is regulated by endoplasmic reticulum-stress, catalyzing BiP AMPylation under low stress conditions to hold inactive chaperone in reserve. In stressed c... |
41779697 | In vivo evaluation of the antibacterial properties of a poly-ε-lysine and hyaluronic acid coated intramedullary implant in a New Zealand White rabbit model. | Peri-prosthetic joint infection (PJI) is a severe complication that can arise following joint replacement surgery. PJI treatment is extremely complex due to the formation of bacterial biofilms and the emergence of antimicrobial resistance (AMR) to antibiotic classes commonly used in the treatment of PJI. This critical ... |
41779630 | A Biomimetic Nanoagonist for Synergistic Photodynamic/Ferroptosis/Disulfidptosis Therapy via Coinhibition of Glucose Metabolism and the SLC7A11/GSH/GPX4 Axis. | Photodynamic therapy (PDT) faces significant challenges in clinical applications, including tumor hypoxia, the poor water solubility of photosensitizers, and insufficient targeting specificity. To address these limitations, we developed a biomimetic nanoagonist, 4T1@MFCB, by coloading a near-infrared photosensitizer (C... |
41779311 | Nanoparticle based siRNA therapeutics for ovarian cancer overcoming drug resistance and future directions. | Recently, nanomedicine has made significant advancements, opening exciting new possibilities for treating a wide range of diseases. In this field, novel drug delivery systems (DDSs) are among the most noteworthy developments. The primary objective of DDSs is to ensure that treatments reach the intended targets while mi... |
41779302 | Advances of Self-Healing Polymers Incorporated in Perovskite Solar Cells for High Durability. | Perovskite solar cells (PSCs) have achieved remarkable power conversion efficiencies (PCE) exceeding 27%, while their operational instability under environmental stress (e.g., moisture, heat, mechanical bending) remains a critical barrier to commercialization. Self-healing polymers (SHPs) with dynamic covalent bonds or... |
41779040 | Acquired resistance in Stenotrophomonas maltophilia: Mechanisms underlying the shift from multidrug to pandrug resistance. | Stenotrophomonas maltophilia is an emerging multidrug-resistant (MDR) pathogen that primarily causes healthcare-associated infections. This bacterium employs two key resistance mechanisms-intrinsic and acquired-to withstand antimicrobial toxicity, facilitating its spread and persistence within healthcare settings. This... |
41779034 | Uncertainty Quantification for <i>In Silico</i> Chemistry. | The rapid growth of worldwide computing power has transformed <i>in silico</i> chemistry into a discipline that is integrated into the daily work of many chemists. Nowadays, researchers find it increasingly straightforward to predict a wide range of molecular properties and chemical processes at reasonable computationa... |
41778992 | Architecture of surface tubular element of poxvirus. | Poxviruses are large enveloped DNA viruses that cause severe human infectious diseases. The mature virion of poxvirus is covered with dense surface tubular elements (STEs), which play a role in assembly progress of mature virions (MVs) and inhibit host cell protein synthesis. However, the composition and assembly of ST... |
41778835 | Supercritical CO<sub>2</sub>-Induced Quinone Confinement and Interfacial Polarization in Microporous Carbon Electrodes for Aqueous All-Organic Batteries. | Aqueous organic batteries provide a sustainable and metal-free alternative to conventional electrochemical storage, with performance often limited by modest active material loading and incomplete utilization inside porous carbon hosts. We report a simple all-organic full cell in which supercritical CO<sub>2</sub> (scCO... |
41778772 | Mutation of Eamy_RS26425, <i>hldE</i>, or <i>pgm</i> renders <i>Erwinia amylovora</i> CFBP 1430 multi-phage resistant and avirulent. | With the rise of antibiotic-resistant pathogens, bacterial infections have become an increasingly significant threat. Bacteriophages have the potential to complement the current treatment options. To ensure that phage biocontrol is efficient and long-lasting, the risk of resistance development must be minimized, and ph... |
41778771 | Adaptive evolution of <i>Candida maltosa</i> improves the bioconversion of depolymerized plastic feedstock by targeting biosurfactant production. | Thermal oxo-degradation (TOD) of plastic can transform plastic waste into fermentable feedstocks. Bioconversion of the TOD products could be used as feedstocks in a biorefinery concept and lead to new avenues for plastic waste upcycling. Previous work demonstrated this concept with high-density polyethylene (HDPE), the... |
41778745 | A Heterometallic Metal-Organic Framework with Atomically Precise Single-Cu Sites for Photocatalysis. | Atomically precise single-atom catalysts (SACs) are essential for establishing reliable structure-activity relationships, yet synthetic routes that afford SACs with fully resolved coordination microenvironments remain a significant challenge. Here we report a secondary building unit (SBU) deconstruction-reorganization ... |
41778672 | Activating a Metallization Switch for Record Hydrogen Evolution in Single-Atom Modified Polar MOF Piezocatalysts. | Piezocatalytic hydrogen evolution enables the conversion of mechanical energy into chemical fuels, but its efficiency is constrained by a trade-off between piezoelectric polarization and electronic conductivity. Strong piezoelectric polarization is essential for sufficient driving force, yet highly polar materials typi... |
41778667 | Anion-Induced Shuttling of Macrocycles in Pyrene- and Anthracene-Stoppered [2]Rotaxane-Based Molecular Switches: X23C7 Shuttling-Induced Superior Fluorescence Enhancement. | Pyrene- and anthracene-stoppered bistable [2]rotaxanes, comprising [23]- and [24]crown ethers, were obtained in high yield by a click reaction. All four [2]rotaxanes exhibited anion-induced shuttling of crown ethers from the ammonium to the methyl triazolium moiety, accompanied by sharp fluorescence enhancements in an ... |
41778643 | Fluorine-Functionalized Pore-Space-Partitioned Metal-Organic Frameworks for One-Step Methane Purification. | The efficient removal of ethane (C<sub>2</sub>H<sub>6</sub>) and propane (C<sub>3</sub>H<sub>8</sub>) from natural gas is vital for purification. A synergistic pore engineering integrating pore space partition and fluorine functionalization in metal-organic frameworks (MOFs), which may effectively promote the C-H···π a... |
41778494 | Water-Soluble Pd<sub>8</sub>L<sub>4</sub> Barrel for Binding of Versatile Hydrophobic Dyes and Visible-Light Promoted Catalysis in Aqueous Medium. | Achieving efficient supramolecular recognition of hydrophobic dyes and their use as photosensitizers in water remain a major challenge because of their inherent insolubility and loss of activity in aqueous medium. We address this issue by designing a metal-organic barrel (M) that combines water solubility with a spacio... |
41778488 | Scalable Production of DNA-Probe-Functionalized Heteromeric MspA Nanopores for Biosensing. | Biological nanopores enable single-molecule sensing but often lack specificity when analytes produce similar current signatures. Covalent tethering of recognition elements improves selectivity, yet site-specific functionalization of symmetric, multimeric pores like <i>Mycobacterium smegmatis</i> porin A (MspA) remains ... |
41778446 | Backbone-Constrained Tripeptides Enable Sequence Control of Solid-State Dynamics. | Understanding how peptide sequence relates to supramolecular dynamics and consequent solid-state material properties remains a central challenge for rational peptide materials design. Here, we use N-terminal proline as a strategic conformational constraint in minimalist tripeptides (PXX; P = proline, X = phenylalanine ... |
41778413 | <i>In Situ</i>-Grown Zeolitic Imidazolate Framework-8@Mg-Fe Layered Double-Hydroxide Heterostructure with Enhanced Adsorption Properties: Insights from Experimental and Computational Investigations. | The removal of organic pollutants, especially dyes, from wastewater remains a critical environmental challenge. Metal-organic frameworks (MOF) and layered double hydroxides (LDH) have individually demonstrated a strong adsorption potential for organic and inorganic contaminants in aqueous media. However, integrating th... |
41778406 | Supramolecular Plasmonic Nanogap Engineering for Machine Learning Decoded Multiplex Chiral Amino Acid SERS Analysis. | Chiral recognition sensing is pivotal in pharmaceutical synthesis and biomedical applications, yet three key challenges persist: the inability to simultaneously achieve high-resolution identification and characterization of enantiomers, insufficient understanding of the molecular mechanisms governing chiral recognition... |
41778389 | Fullerene Photosensitization Within a Self-Assembled Hollow Pd (II) Architecture for Light-Driven Oxidation Reactions in Water. | The efficient conversion of light into chemical energy in water is often hindered by the poor solubility and self-aggregation of the photosensitizers, such as fullerenes, which limit their applicability. Here, we report a self-assembled Pd<sub>8</sub> water-soluble molecular barrel MB that encapsulates and enables effe... |
41777153 | A Cysteine-Specific Cationization Strategy for Versatile Antibody Production against Intrinsically Disordered Proteins. | Several autoantigens relevant to the immune system, especially those targeted by autoantibodies induced by antitumor responses, tend to be rich in disordered regions and are prone to aggregation. This inherent instability presents significant challenges for the production, purification, and analysis of autoantigens in ... |
41776197 | An innovative nasal nanovaccine against SARS-CoV-2 induces systemic and upper airway immunity controlling viral replication. | Respiratory viral infections, such as influenza and coronavirus, are major threats to humankind. Injectable vaccines for SARS-CoV-2 protect against severe disease but fail to induce immunity in the upper airway mucosa, the virus entry site, thus not preventing infection and transmission. This highlights the urgent need... |
41706430 | Computational investigation of carboxyl-functionalized hydrogen-substituted graphdiyne for tracing and trapping nitrogen and its oxides. | Outdoor air pollution has emerged as a critical global concern, primarily driven by the rapid increase in automobile usage, which has led to elevated emissions of nitrogen and its oxides (N<sub>2</sub>, N<sub>2</sub>O, NO, and NO<sub>2</sub>). These exhaust gases pose severe health risks, including cardiovascular and r... |
41706035 | Dual impact of water on stability of metal-organic frameworks. | The widespread application of metal-organic frameworks (MOFs) is hindered by their hydrolytic instability in aqueous and humid environments. To overcome this bottleneck, herein, we evaluate four representative MOFs-MOF-303 (highly stable), MIL-127(Fe) (stable), HKUST-1 (moderately unstable), and UMCM-1 (unstable) - usi... |
41705364 | A retrospective view on curly arrows revealed by the bonding evolution theory and non-covalent interactions: reaction mechanisms meet quantum foundations. | The concept of chemical bonds and the detailed knowledge of how and where the breaking/formation processes occur are perhaps the central research fields in chemical sciences. However, the exact mechanisms underlying these processes still deserve an in-depth explanation. This perspective article systematically describes... |
41696845 | Minimal requirements for one-dimensional aggregation in simple coarse-grained models of charged porphyrinoid units. | We present a Monte Carlo simulation study of cooperative self-assembly of oppositely charged porphyrin-like molecules, with a focus on disentangling the roles of electrostatic attraction and π-π stacking in supramolecular nanowire formation. Electrostatic interactions were described by a screened Debye-Hückel potential... |
41684257 | Molecular basis of signal transduction in a cortisol-binding aptamer. | Understanding the molecular recognition of small molecules such as cortisol, the primary stress-related hormone, by DNA aptamers is critical for advancing molecular biosensing. It is challenging to resolve the mechanisms of this recognition at the molecular level using experiments alone, and insights from molecular sim... |
41604722 | <i>β</i>-CD-polyethyleneimine hybrid alginate macrospheres for the efficient removal of indoxyl sulfate. | Indoxyl sulfate (IS), one of protein bound uremic toxins, is associated with various complications in chronic kidney disease patients and could partially be removed through hemodialysis and hemoperfusion due to its high affinity to human serum albumin. Many studies have demonstrated the potential for blood purification... |
41603894 | The evolution of nanopore measurements: from biological out-of-plane pores to plastic in-plane pores. | Nanopore sensing provides an ideal strategy for the label-free detection of single molecules in a variety of application scenarios. Working under the principle of resistive pulse sensing (RPS), nanopores consist of constrictions with sub-100 nm dimensions to enable single-molecule resolution by matching pore size to ta... |
41498589 | Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function <i>in vitro</i>. | The lymphatic system-integral to fluid balance, immune surveillance, and lipid absorption-is frequently overlooked despite its vital roles. Traditional research modalities, including static two-dimensional cultures and animal models, have illuminated key molecular and cellular features but fall short in recapitulating ... |
41498514 | Paper-based microfluidics for wearable soft bioelectronics. | Wearable biosensing technologies are transforming healthcare by enabling continuous, real-time monitoring of physiological states at the point of care. Flexible microfluidics, particularly paper-based microfluidics, serve as critical interfaces between the body and soft electronics, enabling precise, capillary-driven, ... |
41993622 | Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis. | <h4>Rationale</h4>Tuberculous meningitis (TB meningitis) is a devastating infection where the host immune response drives brain injury. Standard adjunctive corticosteroids often fail to prevent neurological sequelae or improve survival in many populations. Host-directed therapies that can cross the blood-brain barrier ... |
41943385 | Boosting longan seed starch-flavonol complex formation via cold plasma: Structural, functional, and mechanistic insights. | This study systematically investigated how cold plasma (CP) enhances the formation of longan seed starch-flavonol complexes (LS-Fls) to elucidate the underlying structure-property relationships. Results demonstrated that flavonols (FLs) facilitated longan seed starch (LS) rearrangement via non-covalent interactions, fo... |
41943382 | Supramolecular self-assembly of an herbal fructan and chitosan hydrogel: analysis of the fructan, gel structures and the molecular interaction mechanisms. | Polysaccharide-based supramolecular self-assembled hydrogels are promising biomaterials owing to their biocompatibility and dynamic controllability. This study was to explore the use of a polysaccharide (PSP) isolated from a well-known Chinese herb, Polygonatum sibiricum Red. (Huangjing) in the supramolecular self-asse... |
41929451 | Structural analysis of ITS 1 gene of <i>Leishmania tropica</i> and evaluation of a novel ligand, benzo[d][1,3]dioxol-5-yl 4-acetamidobenzenesulfonate, via molecular modeling methods. | <h4>Introduction</h4>Leishmaniasis, a prevalent tropical disease caused by intracellular protozoa of the genus <i>Leishmania</i>, poses significant health challenges globally, exacerbated by migration waves from endemic regions. Despite its widespread impact, an effective vaccine for leishmaniasis remains elusive. Hist... |
41928774 | Phosphoinositide-dependent kinase 1 (PDK1) in cancer: molecular insights and therapeutic strategies. | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) has emerged as one of the most strategically positioned and paradoxically underexploited regulators within Pl3K. It is the main controller of the AGC kinase family, which includes AKT, S6K, SGK, and PKC isoforms. PDK1 is a central signaling hub downstream of the PI3K... |
41905071 | L. AGILIS ALLEVIATES SALPINGITIS IN HENS Lactobacillus agilis alleviates salpingitis through the TLR4/MyD88/NF-κB pathway and gut microbiota interactions in aged laying hens. | Salpingitis in aged laying hens leads to reduced egg production, severely impacting production efficiency. The use of antibiotics poses significant safety risks, necessitating the development of green alternative strategies. This study aimed to investigate the alleviating effects and underlying mechanisms of Lactobacil... |
41901725 | Beyond the Mutation Abyss: Revisiting SARS-CoV-2 Receptor-Binding Domain Evolution from ACE2 Binding Optimization to Immune Epitope Remodeling. | The SARS-CoV-2 Omicron variant and its descendants accumulated unprecedented numbers of spike substitutions yet remained transmissible, implying compensatory mechanisms that preserve entry while eroding humoral immunity. We analyzed 32 variants for sequence-level mutation, physicochemical profiling, and epitope disrupt... |
41900932 | Acute and Long-Term Physiological and Hematological Responses in Well-Trained Young Swimmers Throughout a Training Season. | The physiological and hematological responses to exercise and the corresponding adaptations in high-level sports have become an important issue, from both the health and the physical performance points of view. This study investigated the fluctuations in physiological and hematological variables of young swimmers throu... |
41900927 | Ionic Liquid Biospheres. | Liquid is a fundamental requirement for life as we understand it, but whether that liquid has to be water is not known. We propose the hypothesis that ionic liquids (ILs) and deep eutectic solvents (DES) constitute a class of non-aqueous planetary liquids capable of persisting on a wide range of bodies where stable liq... |
41900809 | An Injectable Thermosensitive Chitosan/Astaxanthin/Ibuprofen Hydrogel Mitigates High-Voltage, Low-Current Electrical Burn Injury Through Inhibition of ROS-NF-κB Signaling-Mediated Inflammation. | <b>Background/Objectives</b>: High-voltage, low-current electric shocks inflict superficial second-degree burns on the skin, accompanied by a vicious cycle of excessive oxidative stress and inflammation. As efficient treatment of such electrical burns remains a clinical challenge, we explored the efficacy of an injecta... |
41900333 | Marine-Derived <i>Bacillus</i> Biosurfactants as Potential Antibacterial and Antibiofilm Agents Against Oral Pathogens. | The growing antimicrobial resistance (AMR) is threatening traditional treatments for oral diseases like dental caries and periodontitis, which constitute a significant global health burden. The study aimed to isolate <i>Bacillus</i> species from marine samples, to assess their biosurfactant-producing capabilities, and ... |
41897316 | Halogen-Containing Drugs in 2025: A Record Year for the Therapeutic Use and Synthesis of FDA-Approved Small Molecules. | Halogens, particularly fluorine, chlorine, and bromine, play a pivotal role in modern drug discovery and development. Their incorporation into drug molecules significantly influences physicochemical properties, including lipophilicity, metabolic stability, and target binding affinity. Fluorine, the most commonly used h... |
41897319 | Engineering the Human Endometrial-Embryo Interface: Breakthroughs in 3D Uterine Models. | Three-dimensional (3D) organoid and co-culture models have emerged as transformative tools for studying human endometrial function, implantation, and placental development, overcoming key limitations of animal and two-dimensional in vitro systems. This review synthesises available information of recent advances in endo... |
41893282 | AI in Membrane Design and Optimization for Hydrogen Fuel Cells. | This paper reviews artificial intelligence (AI) applications in the design and optimization of proton exchange membrane (PEM) materials for hydrogen fuel cells. Clean energy conversion is a substantial benefit of PEM fuel cells, which conventional membrane development struggles with due to time-consuming trial-and-erro... |
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