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41893178 | LXW7 Peptide Modification of Acellular Liver Scaffolds Improves Endothelialization and Hemocompatibility in Bioengineered Liver. | End-stage liver disease caused by advanced fibrosis and cirrhosis remains a major global burden, yet its treatment is limited by donor organ shortages. Bioengineered liver scaffolds offer a promising alternative, but their efficacy is often limited by thrombosis, insufficient vascularization, and poor graft integration... |
41892628 | Reduced Cortical Pyramidal Neuron Membrane Excitability and Synaptic Function in Parkinsonian Mice and Their Restoration by L-Dopa Treatment: Indirect Mediation by Striatal Dopaminergic Activity. | <b>Background</b>: We previously established that striatal, but not cortical, dopaminergic activation stimulates movement, indicating that the crucial and original site of dopaminergic stimulation of motor function is the striatum, not the motor cortex. In the present study, we have further investigated the potential e... |
41892104 | Biomimetic Anisotropy for Directional Transport of Liquid and Solid Samples. | Biomimetic anisotropy is defined as intentionally engineered, nature-inspired directional differences in structure, chemistry, roughness, stiffness, or pore architecture. These directional differences lower transport resistance in one direction relative to the opposite direction, which results in rectified transport. I... |
41892100 | Regulating the Crystalline Structure and Ion Affinity of Covalent Organic Frameworks for Enhanced Lithium/Magnesium Separation. | Selective ion transport is essential for many applications of membrane separation, such as rare metal and high-value element extraction from complex ionic sources. However, efficient regulation of permeability-selectivity remains a major challenge for advanced ionic transport membranes. Herein, we demonstrate that supe... |
41892040 | Imprinted Proteins as a Receptor in Fluorescent Sensing Microplate Assay for Herbicide Determination. | The manuscript describes an optical sensing microplate for the high-throughput screening of imidazolinone herbicides in soil extracts. As far as we know, imprinted proteins (IPs) specific to imidazolinone herbicides have not been synthesized and used as a recognition element for their solid-phase extraction before. Imp... |
41892038 | Sensitive Detection of DJ-1 in Artificial Cerebrospinal Fluid Using a Portable GPTMS-Coordinated Gold Nanoparticle-Based Biosensor. | A highly selective and sensitive compact immunosensing strategy was developed for the determination of DJ-1, a potential biomarker of Parkinson's disease, one of the leading neurodegenerative disorders, using a portable potentiostat. Initially, screen-printed carbon electrodes (SPCEs) were modified with gold nanopartic... |
41889773 | Multisite Phosphorylation Regulates the Structure and Auto-Inhibitory Function of the Intrinsically Disordered N‑Terminal Domain of p53. | Multisite phosphorylation plays an important role in essential cellular processes such as cell cycle control and circadian rhythm regulation and is also closely involved in the onset and progression of cancer and neurodegenerative diseases. As one of the most critical human tumor suppressor proteins, p53 is greatly mod... |
41889758 | Chemical Strategy and AI-Enabled Peptide Vaccine Development. | Peptide vaccines have emerged as a versatile platform complementing traditional vaccines by offering high safety, precise epitope targeting, and ease of manufacturing; however, they suffer from intrinsically weak immunogenicity, human leukocyte antigen (HLA) restriction, and poor <i>in vivo</i> stability. Recent progre... |
41889741 | Targeted Discovery of β‑Branched Conjugated Polyketides from Bacteria Based on Genomic and Metabolomic Hallmarks. | A logical discovery method based on metabologenomic targeting was designed to search for new β-branched conjugated polyketides. PCR screening of a bacterial DNA library (1,638 strains) targeting the key enzyme hydroxymethylglutaryl-CoA synthase (HCS) homolog-encoding gene as a genomic hallmark identified 67 hit strains... |
41874155 | Improving Laboratory-Based Cancer Drug Discovery Study Designs for Better Research Translations. | The process of developing a drug is complex and involves many steps, from basic research (bench) to patient applications (bedside), which are conducted to ensure the drug is both safe and effective. In cancer research, the failure rate is high when translating basic findings to clinical trials. One of the main factors ... |
41869349 | Innate immune recognition and evasion strategies of hepatitis B virus: from DNA to RNA and viral proteins. | Innate immunity constrains the hepatitis B virus (HBV) by sensing pathogen-associated molecular patterns (PAMPs) and inducing type I/III interferons and interferon-stimulated genes. This review synthesizes molecular mechanisms by which HBV nucleic acids and proteins are detected by pattern recognition receptors (PRRs) ... |
41867611 | Dual-Responsive Micelles Co-delivering All-Trans Retinoic Acid and Paclitaxel for Enhanced Eradication of Osteosarcoma Stem Cells. | Osteosarcoma is the most prevalent primary bone cancer affecting children and adolescents, characterized by its high invasiveness and the challenges in treatment posed by multidrug resistance. Cancer stem cells significantly contribute to poor clinical outcomes; however, current targeted therapies remain limited in the... |
41867609 | Modeling of Methanol Steam Reforming in a Monolith Reactor: Effects of Internal Diffusion, Substrate Parameters, and Operating Conditions. | Methanol steam reforming is a promising method to achieve on-site hydrogen production for fuel cell applications. The characteristics of fluid flow, heat transfer, and mass transfer within advanced reactors still call for further investigation. A computational fluid dynamics simulation study of methanol steam reforming... |
41867566 | Production of 5‑Hydroxymethylfurfural from Glucose under Hydrothermal Conditions. | 5-Hydroxymethylfurfural (5-HMF) is an important biomass-based platform molecule with various commercial applications, and its green, efficient production is the key for value-added applications of lignocellulosic biomass. This work studied the preparation of 5-HMF from glucose using autogenic H<sup>+</sup> and OH<sup>-... |
41867519 | Adsorption Performances of Water-Stable MIL-160(Al) at Scale: An Alternative to FAM-Z02 in Water Harvesting and Chillers. | Efficient utilization of low-grade waste heat is key to reducing the carbon footprint of cooling and water-harvesting technologies. Adsorption-based devices employing porous materials enable thermally driven heat exchange and atmospheric water capture with low environmental impact. While zeotype materials such as SAPO-... |
41859687 | ImmUQBench: a benchmark on uncertainty quantification of protein immunogenicity prediction. | Discovering antigen proteins, capable of eliciting desired immune responses, is of paramount importance in developing immunogenic therapeutics for combating various diseases, particularly autoimmune disorders, infectious diseases, as well as cancers. Despite recent advances in artificial intelligence (AI) and machine l... |
41858409 | Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function. | Over the last few decades, physical principles have been proposed to explain some biological processes and functions. However, biological principles remain elusive. A biological principle is a governing rule that guides the structure and functions of cells. Biological principles are built upon the laws of physics and c... |
41853721 | GII.23/24/25 noroviruses recognize glycans via a conventional glycan-binding site. | <h4>Introduction</h4>Human noroviruses (HuNoVs) are genetically diverse RNA viruses that cause acute gastroenteritis, with genogroup II (GII) accounting for over 90% of global infections. Glycans, particularly histo-blood group antigens (HBGAs), have been identified as attachment factors or receptors for HuNoVs infecti... |
41853685 | Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 reveal a structural basis for its functional regulation. | The RNA-binding protein hnRNPA2B1 is critical for mRNA processing, transport, metabolism, and antiviral innate immunity. Its activity is modulated by various ligands, including RNA, single-stranded DNA (ssDNA), and the small-molecule agonist PAC5, but the structural dynamics of these ligand-specific modulations are not... |
41853314 | AI-powered mapping of tumor immunity for optimized mRNA vaccine engineering. | Messenger RNA (mRNA) vaccines represent a versatile and scalable platform for cancer immunotherapy; however, their clinical efficacy depends critically on precise vaccine design capable of eliciting robust, selective, and durable antitumor immune responses. Recent advances in bioinformatics and artificial intelligence ... |
41853312 | Lactate metabolism and protein lactylation in colorectal cancer: from metabolic reprogramming to epigenetic regulation. | Colorectal cancer (CRC) exhibits profound metabolic reprogramming, in which excessive lactate accumulation remodels the tumor microenvironment and promotes immune suppression, angiogenesis, and therapeutic resistance. Recent studies reveal that lactate also serves as a substrate for lysine lactylation (Kla), linking me... |
41853291 | Hyperbaric oxygen therapy modulates immune effector responses and reshapes peripheral immune tolerance: a narrative review. | Hyperbaric oxygen therapy (HBOT) refers to an intervention in which patients inhale near-100% oxygen at pressures exceeding 1 atmosphere absolute to increase plasma and tissue oxygen partial pressure. HBOT has been applied clinically across a broad range of conditions, including infections, inflammation, hypoxia-relate... |
41853278 | Spatiotemporal control of immunogenic cell death: rewiring tumor-immune dialogues for next-generation immunotherapy. | Immunogenic cell death (ICD) is a regulated cell death process distinguished by its ability to stimulate an adaptive immune response. This occurs through the emission of damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), adenosine triphosphate (ATP), High Mobility Group Box 1 (HMGB1), type I inte... |
41852880 | Hyaluronan open-pit nanofibrils with spontaneous cell-matrix assembly for advanced osteochondral defect repair. | While hyaluronic acid (HA) inherently promotes chondrogenesis, its hydrophilic character and lack of receptor-specific ligands impede robust cell adhesion - underscoring the need for nanofibrous matrices that emulate the extracellular microenvironment to enhance cell - matrix interactions. Therefore, we designed HA-bas... |
41852634 | Revolutionizing Sun Protection: Emerging Nanotechnologies Shaping the Future of Sunscreens. | Sun protection has become a significant public health issue in recent decades due to the high incidence of skin diseases related to excessive exposure to ultraviolet (UV) rays. The use of nanosystems in sunscreens represents a promising innovation in the pharmaceutical and cosmetic fields. This paper aims to map and ch... |
41835454 | Photoclickable Halotag ligands for spatiotemporal multiplexed protein labeling on living cells. | Precise spatiotemporal control over fluorescence labeling is a powerful approach for selective marking and tracking of proteins of interest within living systems. Here, we report a photoclickable labeling platform based on the 2,3-diaryl-indanone epoxide (DIO) photoswitch scaffold and the self-labeling protein HaloTag.... |
41828580 | From Microscopy to Nanoscopy: Contemporary Physical Methods in Mitochondrial Structural Biology. | Mitochondria play a crucial role in cellular bioenergetics, signaling, and metabolism; yet, many fundamental mechanisms such as the proton transfer along the membranes, the link between membrane curvature and oxidative phosphorylation, and the nanoscale organization of enzyme supercomplexes remain poorly understood due... |
41820209 | Folic Acid-Conjugated Nanocarriers for Targeted Cancer Therapy: Recent Patents and Future Prospects. | As folate receptors are overexpressed on the surface of many tumor cells, folic acidconjugated nanocarriers have emerged as a promising approach for targeted cancer therapy. These nanocarriers enhance therapeutic efficacy while reducing systemic toxicity and adverse effects by enabling selective drug delivery. The desi... |
41816619 | Realizing luminescent single crystals of covalent organic polymers with color-tunable emission through isomer engineering. | Preparing luminescent single crystals of B-N-containing covalent organic polymers (COPs) is very important but highly challenging, since most conditions only produce luminescence-silent crystals. To address this issue, we employ an isomer engineering strategy to successfully prepare luminescent (CityU-50) and luminesce... |
41815936 | Mechanisms of enhanced or impaired DNA target selectivity driven by protein dimerization. | Successful DNA transcription demands coordination between proteins that bind DNA while simultaneously binding to one another to form dimers or higher-order complexes. For proteins with numerous DNA targets throughout the genome, measurements that report on their dwell time or occupancy thus represent a convolution over... |
41809554 | An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery. | Small molecule ion transporters have shown promise as potential therapeutics for microbial infections, cancer and channelopathies. However, there are still gaps in our understanding of how ion transport function in model vesicle membranes translates to cell membranes of interest. The lipid composition of the membranes ... |
41806736 | Supramolecular assembly of squaraine dye for visual detection of paraquat via an indicator displacement assay. | Paraquat (PQ), a highly toxic and persistent herbicide, poses severe risks to environmental and public health. Herein, we developed a supramolecular indicator displacement assay (IDA) for PQ detection using a squaraine dye (J3-Ad) and cucurbit[7]uril (CB7). PQ displaces J3-Ad monomers from the J3-Ad&CB7 (J3&CB) complex... |
41804452 | Multifunctional Glycine-Carbon Dots Protect Against Arsenic Hepatotoxicity Through Redox Balance and PI3K/AKT Activation. | <h4>Background</h4>The theranostic potential of glycine-derived carbon dots (Gly/CDs) against arsenic-induced hepatotoxicity remains largely unexplored. This study aimed to synthesize Gly/CDs via a green, microwave-assisted method and to systematically evaluate their hepatoprotective efficacy and underlying mechanisms ... |
41802368 | Multiscale Bi/Bi<sub>2</sub>O<sub>3-x</sub> Mott-Schottky heterojunction confined in hierarchical mesoporous carbon for advanced aqueous alkaline batteries. | Bi<sub>2</sub>O<sub>3</sub> emerges as a promising alkaline battery anode material due to its high theoretical capacity (380 mAh g<sup>-1</sup>) and reversible Bi<sup>3+</sup>/Bi<sup>0</sup> redox chemistry. However, persistent challenges including insufficient active site exposure and low intrinsic conductivity result... |
41800437 | Innovative Strategies of Nanocapsules for Maximizing Efficacy in Tumor Immunotherapy. | This review explores nanocapsules as a versatile platform to overcome the limitations of drug resistance inherent in conventional cancer therapy and immunotherapy. These nanosystems are capable of enhancing drug delivery, facilitating immune activation and modulating the tumor microenvironment. The review systematicall... |
41795532 | Peroxidase-like NH<sub>2</sub>-MIL-101(Cr)-enabled fluorescence sensing of ofloxacin in honey through charge transfer modulation. | A critical need exists for advanced methods to monitor fluoroquinolones in food products. This work presents a sensitive fluorescence strategy for ofloxacin (OFL) detection in honey utilizing NH<sub>2</sub>-MIL-101(Cr), a chromium-based metal-organic framework synthesized hydrothermally. The framework exhibits intrinsi... |
41795254 | Interaction of astaxanthin with bovine serum albumin: Role of aggregation state. | Astaxanthin-binding proteins contribute to the vibrant coloration of various organisms. Inspired by nature, artificial astaxanthin-protein systems have been developed for food applications. However, due to the structural diversity of proteins and the variable aggregation states of astaxanthin (AST) in aqueous environme... |
41791144 | A magnetic-fluorescent integrated platform for three-in-one sensing of doxycycline in food with enhanced sensitivity and specificity. | A magnetic-fluorescent integrated platform (Fe<sub>3</sub>O<sub>4</sub>-COOH@MIL-101(Cr)@MIPs/b-BCDs), designed for the magnetic separation, biomimetic recognition, and fluorescence detection of doxycycline, was proposed. In this proposal, Fe<sub>3</sub>O<sub>4</sub>-COOH@MIL-101(Cr)@MIPs were synthesized through layer... |
41786216 | CpG oligodeoxynucleotide reduces PrP<sup>Sc</sup> accumulation and prolongs survival in prion-infected mice. | Prion diseases, also known as transmissible spongiform encephalopathies, are characterized by the accumulation of misfolded prion proteins (PrP<sup>Sc</sup>), which resists clearance due to impaired removal mechanisms and immune tolerance. Although strategies aimed at enhancing intracellular clearance pathways, includi... |
41786225 | Adsorption behavior of trace polycyclic aromatic hydrocarbons in vegetable oil by β-cyclodextrin-decorated activated carbon. | Polycyclic aromatic hydrocarbons (PAHs) pose a significant health burden when present in food, and their removal from oils without losing trace nutrients and oil flavor is a persistent challenge. This study introduces a novel approach to selectively eliminate trace PAHs from edible oil. A composite adsorbent, termed β-... |
41786179 | Non-covalent interaction-driven assembly of antimicrobial potato protein/ε-polylysine hydrochloride/tannic acid bioplastics for blueberries preservation. | In this study, ε-polylysine hydrochloride (ε-PL) and tannic acid (TA) were incorporated into a potato protein matrix to develop composite films with non-covalent networks, and their structural characteristics and functional properties were systematically investigated. Compared with the pure protein film, the developed ... |
41786167 | Non-covalent complexation of zein with hemp seed Cannabisins A and Cannabisins B: Molecular mechanisms, structural characterization and enhanced functional properties. | This study investigated the non-covalent interactions between zein and hemp seed phenolics-Cannabisin A (CA) and Cannabisin B (CB)-to elucidate the mechanisms underlying their functional enhancement. Molecular docking indicated strong binding affinities driven by hydrophobic interactions and hydrogen bonding. Spectrosc... |
41786146 | The Welander TIA1 mutation dedifferentiates insulin-producing cells: Reversal by a GLP-1 receptor agonist. | The RNA-binding proteins TIAR and TIA1 have been reported to affect beta-cell insulin production and viability. The missense E384K TIA1 autosomal dominant mutation is known to cause Welander distal myopathy. This study aimed to study the effects of the TIA1 E384K mutation in human insulin-producing EndoC-βH1 cells. The... |
41783683 | Mechanistic insights into CO<sub>2</sub>-driven hydration of propargylic alcohols catalyzed by oxometallate ionic liquids. | Oxometallate-based ionic liquids, exemplified by tetrabutylammonium molybdate, have recently emerged as efficient and recyclable catalysts for CO<sub>2</sub>-assisted hydration of propargylic alcohols under mild conditions. In this work, density functional theory (DFT) is employed to provide an in-depth mechanistic inv... |
41783042 | Fabricating Inorganic/Organic S-Scheme Heterojunction for Efficient Photocatalytic Production of H<sub>2</sub> and H<sub>2</sub>O<sub>2</sub>. | Enhancing the efficiency of photocatalytic H<sub>2</sub> evolution and H<sub>2</sub>O<sub>2</sub> production through heterojunction engineering is crucial for addressing energy sustainability and environmental challenges. In this context, constructing S-scheme heterojunctions has emerged as a promising strategy. Here, ... |
41783015 | Automated Plasmon-Selective Laser Writing in Mesoporous Thin Films Through Decoupling of the Initiator Absorption and Plasmon Wavelength. | Enhancing nanopore functionalization precision is relevant to advance future-relevant technologies such as molecular sensing, separation, catalysis, and energy conversion. An interesting approach for high-resolution polymerization is to use nanoscale light sources like surface plasmons. To design polymer functionalizat... |
41780400 | Nanoconfined biosensor for attomolar molecule detection and recycling via DNA strand displacement. | Attomolar-level biomolecular detection remains challenging due to inefficient molecular collisions and weak signal transduction at ultralow concentrations. Here, we introduce a recyclable nanoconfined biosensing platform (ABA@N<sub>C</sub>B<sub>S</sub>) for adenosine triphosphate (ATP) detection. This platform integrat... |
41777068 | Multimodal Operando Characterization of Cation Effects at the Iridium Oxide-Electrolyte Interface for Alkaline Water Oxidation. | Understanding the electrode/electrolyte interface is essential for tuning electrocatalyst activity. Here, we combine operando optical spectroscopy, laser-induced current transient (LICT) measurements, and surface-enhanced infrared absorption spectroscopy (SEIRAS) to investigate the origin of cation-dependent oxygen evo... |
41776998 | Three-Component CO<sub>2</sub> Conversion to Carbonyl Carboxylates Catalyzed by a Copper-Based Metal-Organic Framework under Mild Conditions. | The conversion of CO<sub>2</sub> into valuable chemicals is crucial for the sustainable carbon utilization. The three-component reaction of CO<sub>2</sub> with propargylic alcohols and monohydric alcohols to form carbonyl carboxylates is highly attractive but typically requires noble-metal catalysts under harsh conditi... |
41776961 | Exploring the Structural Basis of Cryptic Pocket Formation Driven by Extensive Protein Conformational Changes in Drug Targets. | Allosteric pockets that typically only emerge in the presence of a binder, known as cryptic pockets, can provide an avenue for drug discovery in challenging pharmaceutical targets. However, protein conformations exposing cryptic pockets are generally short-lived and can require significant structural rearrangements tha... |
41776811 | Molecular Foundation Models for Predicting Self-Assembly in Aqueous Mixtures. | Pretrained foundation models offer new representations for molecular structures but have predominantly been applied to single-component property prediction. Here, we develop a concentration-weighted average of the latent representations of graph neural network and transformer-based molecular foundation models to predic... |
41776763 | Trade-Off between Adsorption and Regeneration in Functional Metal-Organic Frameworks for Atmospheric Water Harvesting: A Multiscale Modeling Approach. | Understanding the trade-off between water adsorption and regeneration efficiency is essential for the rational design of functional metal-organic frameworks (MOFs) for atmospheric water harvesting (AWH). In this work, Cu-halide-functionalized MOF-303 is employed as a representative case study. A multiscale modeling fra... |
41776767 | Reprogramming Lesional Macrophage Homeostasis via Interferon Regulatory Factor 5 Targeted siRNA Nanoimmunotherapy for Atherosclerosis. | Atherosclerotic macrophages predominantly exhibit a pro-inflammatory phenotype, driving chronic inflammatory and accelerating atherosclerotic progression. Interferon regulatory factor 5 (IRF5) is highly expressed in lesional macrophages within advanced atherosclerotic plaques, where it promotes the secretion of pro-inf... |
41776731 | One Probe, Two Readouts: A Fluorescent Nanozyme Facilitates Cascade Catalysis and On-Demand Bimodal Detection of Hepatic ALT and AST. | Probing the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) is of significance for clinical diagnosis of hepatic diseases and monitoring of therapeutic effects. Traditional detection methods often rely on a single signal driven by cascade catalysis of multiple natural enzymes, exposing... |
41776416 | Manipulating Molecular Configurations of Organic Charge-Transfer Cocrystals with Programmable Near-Infrared Emission for Dual-Emission Optical Waveguide. | Molecular engineering in molecular configuration was successfully applied to finely design the advanced organic semiconductors. However, it has rarely been investigated in organic charge-transfer (CT) cocrystals with desired optoelectronic properties that could be controllably prepared via a facile self-assembly proces... |
41776398 | Precisely Creating Enzyme-Mimetic Metal-Organic Framework for Unnatural Peptide Synthesis. | Unnatural γ-amino acids and peptides have emerged as essential pharmacophores and versatile building blocks in drug molecules and biomaterials owing to their relatively flexible structures that enable unique interactions with specific biological targets. Despite their promising potential, nature lacks systematic biosyn... |
41776350 | PANoptosis as a drug discovery framework: integrating cell death architecture with clinical translation. | Programmed cell death pathways-apoptosis, pyroptosis, and necroptosis-were long regarded as discrete entities, yet mounting evidence reveals their convergence in PANoptosis, a unified inflammatory death program orchestrated by supramolecular PANoptosome complexes. By integrating upstream sensors (ZBP1, AIM2, NLRP3, Pyr... |
41776223 | MtrE Loop2-specific multiple antigenic peptide vaccine and monoclonal antibody confer complement-dependent protection against Neisseria gonorrhoeae. | Neisseria gonorrhoeae imposes a substantial global health burden due to its high incidence and escalating multidrug resistance. This study investigated the immunogenicity and efficacy of a peptide-based vaccine and a monoclonal antibody (mAb) targeting the conserved Loop2 epitope of the outer membrane protein MtrE. Two... |
41776165 | Chemodivergent Coupling of 1,3-Enynes with Anilines to Access Dihydropyrrole Skeleton under Palladium Catalysis. | 2,5-Dihydropyrroles are prevalent structural motifs in various natural products and biologically active molecules. Conventional methods for constructing these heterocycles often rely on elaborate multi-step procedures or complex starting materials. Herein, we describe a palladium-catalyzed chemodivergent protocol for s... |
41776152 | Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C Disease. | <h4>Purpose</h4>Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunit... |
41776155 | Engineering molecular rotor-stator ligand architectures on copper nanoclusters for efficient photothermal conversion. | Copper nanoclusters represent a promising yet underdeveloped frontier in materials science. Here, we propose a general and efficient strategy for enhancing photothermal conversion efficiency through the incorporation of rotor-stator ligand architectures onto copper nanocluster surfaces. As a representative example, we ... |
41776123 | Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors. | Pediatric malignant brain tumors (PMBTs) remain among the most common and challenging cancers in children and adolescents, with current therapies often failing to deliver satisfactory outcomes. A major obstacle is their intrinsic and extrinsic resistance mechanisms, underscoring the urgent need for innovative therapeut... |
41776064 | Genome mining and screening for plastic-degrading potential in marine bacteria. | Marine plastic litter, including microplastics, has a profound impact on the ocean and its wildlife, and strategies to remove/eliminate it are needed. Microbial biodegradation, particularly by bacteria, offers a potential solution, where a link between hydrocarbon and plastic-degradation has been hypothesized. This stu... |
41776042 | Next-generation electrochemical aptasensors for thrombin detection: the rise of aptamer-MOF architectures. | Thrombin is a crucial regulatory enzyme in the blood coagulation cascade that significantly influences cancer metastasis, cardiovascular disease, inflammation, and immunological regulation. Because of its dynamic, concentration-dependent activity, thrombin has emerged as a potential biomarker for the early diagnosis of... |
41775746 | Optimizing cross-domain transfer for universal machine learning interatomic potentials. | Accurate yet transferable machine-learning interatomic potentials are essential for accelerating materials and chemical discovery. However, many existing universal models are overfitted to narrow chemical spaces or computational protocols, limiting their reliability across diverse chemical and functional domains. Here,... |
41775743 | Topological magneto-optical Kerr effect without spin-orbit coupling in spin-compensated antiferromagnet. | The magneto-optical Kerr effect (MOKE), the differential reflection of oppositely circularly polarized light, has traditionally been associated with relativistic spin-orbit coupling (SOC), which links a particle's spin with its orbital motion. In ferromagnets, large MOKE signals arise from the combination of magnetizat... |
41775734 | Integrated computational and experimental immunoengineering of adeno-associated virus capsid T cell epitopes in mice. | Adeno-associated virus (AAV) vectors are widely used in gene therapy, but their immunogenicity remains a significant challenge, limiting long-term efficacy and the feasibility of repeated administration. In this study, we combine computational prediction with experimental validation to engineer AAV9 capsids with reduce... |
41775657 | Droplet-Engineered Scalable High-Throughput Perovskite Micropatterning for Next-Generation Optoelectronics. | Droplet-based patterning techniques have demonstrated great effectiveness in fabricating highly ordered arrays for applications of functional materials in photonics, optoelectronics, and sensing technologies. Droplets act as small units and microreactors, providing controlled physical or chemical interactions, thereby ... |
41775518 | Highly Efficient Zinc-Based Metal-Organic Framework for Adsorptive Removal of Congo Red: Experimental Investigation and AI-Driven Validation. | Mitigating hazardous environmental hazards, such as organic dyes present in water, remains a pressing challenge. In this study, a highly efficient zinc-based Metal-Organic Framework (MOF) is successfully employed for the adsorptive removal of Congo Red (CR) from aqueous solution. Experimental design was validated using... |
41775340 | Advancing Collision-Induced Affinity Selection Mass Spectrometry for Quantitative Ligand Analysis in Complex Mixtures. | Native mass spectrometry (MS) is a powerful technique for studying protein-ligand interactions in their native states by employing soft electrospray ionization (ESI). It enables the direct observation of all species in equilibrium within a solution. Building on these advantages, Collision-Induced Affinity Selection MS ... |
41774842 | Supramolecular Binding and Extraction of Phosphate, Phosphite and Fluorophosphate Anions from Water by Nanojars. | In this work, the supramolecular binding of HPO<sub>4</sub><sup>2-</sup>, HPO<sub>3</sub><sup>2-</sup> and FPO<sub>3</sub><sup>2-</sup> ions by nanojars of the general formula [XPO<sub>3</sub><sup>2-</sup>⊂{<i>cis</i>-Cu<sup>II</sup>(μ-OH)(μ-pz)}<sub><i>n</i></sub>]<sup>2-</sup> (<b>Cu</b><sub><b><i>n</i></b></sub><b>X... |
41774813 | Characterization of Fused Mn and Cu Corroles and Their Potency as ORR Electrocatalysts. | Given the rather poor activity of regular copper and manganese corroles as electrocatalysts for the oxygen reduction reaction (ORR), we now report the synthesis, structural characterization, and catalytic activity of binuclear manganese and copper complexes coordinated to β-β dimeric corrole frameworks. X-ray crystallo... |
41774794 | ATP synthase activity boosts membrane proton acceptance and lateral diffusion. | In most organisms, ATP synthesis is powered by the proton motive force (pmf) and catalyzed by ATP synthase. While the chemiosmotic theory originally proposed a "delocalized coupling" between proton pumps and consumers, growing evidence implicates the membrane in mediating localized proton transfer (PT). To directly tra... |
41774787 | FUT1- and GAL3ST2-mediated cellular glycan remodeling broadly restricts sialic acid-dependent viral infections. | Sialic acid is an abundant terminal glycan found on the surface of almost all mammalian cells and is utilized by many viruses as an attachment factor and/or bona fide receptor. Altering canonical cellular glycosylation can affect the ability of viruses to initiate infections; however, no systematic analysis of the effe... |
41774777 | Fatal human H3N8 influenza virus has a moderate pandemic risk. | In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections, with the last one in 2023 being fatal. Here we evaluated the relative pandemic risk of this 2023 zoonotic H3N8 influenza virus, utilizing our previously published decision tree. Ser... |
41774509 | [Association of platelets with multiple organic failure in septic patients]. | <h4>Background</h4>Sepsis is a proinflammatory and procoagulant condition; platelet abnormalities constitute the main alteration, with thrombocytopenia being the most prevalent. This variation is due to multiple mechanisms, primarily the formation of microcirculatory thrombi, which leads to increased consumption. A pot... |
41774471 | Effect of Cellulose Nanofiber Length on Magnetic Separation Performance and Biotin-Streptavidin Conjugation Efficiency of CNF/Fe<sub>3</sub>O<sub>4</sub> Composite Particles Prepared via Spray Synthesis. | Spray-dried TEMPO-oxidized cellulose nanofiber (TOCN)-Fe<sub>3</sub>O<sub>4</sub> (TF) composite particles were fabricated using TOCNs of distinct fiber lengths, where the long TOCNs were approximately 3 times longer (around 1 μm) than the short TOCNs (approximately 350 nm). The objective was to elucidate how nanofiber... |
41774368 | Catalyzing innovation: exploring the potential of eco-friendly synthesized magnetic iron oxide nanoparticles for heavy metals removal from water. | Iron oxide nanoparticles (IONs) due to its properties have taken over the applications to remove industrial waste, can treat wastewater, and catalyze reactions. The emerging green nanotechnology has emerged as a sustainable and eco-friendly approach for synthesizing IONs. The most effective iron oxide nanoparticles wit... |
41774334 | Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis. | Deltaretroviruses, including Human T-cell Leukemia Virus type 1 (HTLV-1) and Bovine Leukemia Virus (BLV), are oncogenic pathogens that exploit host transcriptional machinery to establish persistence and drive malignant transformation. Central to this process is the cAMP response element-binding protein (CREB), a transc... |
41774309 | Recent advances in functionalized nanocarbon adsorbents for toxic pollutant removal: challenges and future perspectives. | The increasing release of toxic pollutants into water bodies, especially heavy metal ions (HMs), poses severe environmental and health challenges. Among various remediation techniques, adsorption using functionalized carbon nanomaterials has emerged as an efficient and sustainable approach due to their high surface are... |
41774266 | Mitochondrial function meets oncology: the multifaceted role of TFAM across cancer types. | Mitochondrial transcription factor A (TFAM) is indispensable for mitochondrial DNA (mtDNA) maintenance and transcription, governing cellular bioenergetics. Despite its known physiological importance, TFAM plays a complex and often paradoxical role in cancer biology. This study integrates pan-cancer bioinformatics analy... |
41774250 | Theoretical insights into the enhanced gas-sensing properties of Al-, P-, and AlP-doped BN nanosheets. | <h4>Context</h4>Boron nitride nanosheets (BNNS) possess high thermal stability and large surface area; however, their inherently wide band gap and weak adsorption capability limit their effectiveness in gas-sensing and gas-storage applications. This study investigates the adsorption and sensing behavior of H<sub>2</sub... |
41774122 | The Biggest Challenge for Prediction of Membrane Permeability of Cyclic Peptides: Scarce Data Availability. | AI-based multiparameter optimization for membrane permeability of cyclic peptides is hampered by the limited availability of ground truth biological data. This Viewpoint highlights the Featured Article reporting an AI model, integrating a high-throughput assay classifying billions of cyclic peptides for permeability-re... |
41774106 | Strand displacement-triggered biocatalytic precipitation on ZIF-8/Bi<sub>2</sub>S<sub>3</sub> photoelectrode: an aptasensing platform for sub-nanomolar kanamycin determination. | Growing needs for monitoring kanamycin (KAN) residues in food require ultrasensitive, field-deployable determination platforms. Herein, we present a universal photoelectrochemical (PEC) aptasensing strategy that synergizes ZIF-8/Bi<sub>2</sub>S<sub>3</sub> heterostructure-engineered photoelectrodes with strand displace... |
41773953 | Investigating Cu(II) Complexes for MRI: A Comprehensive Approach Using EPR, Relaxometry, and Computational Modeling. | The development of Gd-free MRI contrast agents requires a detailed understanding of the structural and electronic factors governing paramagnetic relaxation in first-row transition-metal complexes. In this work, we integrate EPR spectroscopy, Q-band ENDOR, variable-temperature <sup>17</sup>O NMR, field-dependent <sup>1<... |
41773916 | Pronounced Fluorescence Polarization Enhancement Driven by RPA-CRISPR/Cas12a Induced Nucleoprotein Assembly for <i>Salmonella</i> Analysis in Animal-Derived Food Matrices. | <i>Salmonella</i> is one of the most hazardous foodborne pathogens, posing a serious threat to public health and food safety worldwide. Conventional recombinase polymerase amplification (RPA)-CRISPR/Cas12a detection assays predominantly rely on the trans-cleavage of fluorescent reporters; however, such signal-generatio... |
41773879 | Targeted sortase A inhibition by novel peptidomimetic antivirulents against staphylococcal infections. | Antibiotic resistance is a critical public health issue, causing resistant bacterial strains to be increasingly difficult to control. Antivirulence therapies, which target bacterial virulence factors rather than kill bacteria, present a promising approach. Sortase enzymes, particularly SrtA, are crucial for gram-positi... |
41773865 | ATP1A1 enhances porcine reproductive and respiratory syndrome virus type 2 attachment and internalization. | Na<sup>+</sup>-K<sup>+</sup>-ATPase alpha subunit 1 (ATP1A1) is the main functional part of the sodium pump. In addition to the well-known role in ion transport, it also acts as a signal transducer. Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) utilizes multiple entry factors and pathways to init... |
41773658 | Engineering Freestanding Porous Carbon Electrodes by Self-Assembled Colloidal Liquid Crystalline Phase. | Highly ordered pore channels can effectively improve mass transport in porous electrodes. However, due to the inherent trade-off between high porosity and structural regularity, achieving an ordered pore channel in practical highly porous electrode materials remains a challenge. To address this issue, we present a simp... |
41773643 | A ZrO<sub><i>x</i></sub>H<sub><i>y</i></sub>-Templated UiO-66 Composite as a Heterogeneous Nanozyme for Site-Specific Myoglobin Proteolysis. | Protein hydrolysis plays a crucial role in proteomics research, especially in disease mechanism studies, biomarker discovery, and drug target screening. However, existing natural enzymes still face challenges that prompt the development of more robust and tunable materials such as metal-organic frameworks (MOFs) that m... |
41773625 | Nanotechnology based targeted drug delivery systems for breast cancer: challenges, recent advancement and future perspectives. | Globally, breast cancer remains a leading causes of cancer-related mortality among women, emphasizing the need for more effective therapies. Nanotechnology-based drug delivery systems have emerged as promising tools for reducing systemic toxicity while enhancing the precision and efficacy of treatments. By engineering ... |
41773468 | Programmable Stereoregular Fully Aromatic-Substituted Polymethylenes. | The discovery of new classes of polymers continues to redefine the scope of macromolecular chemistry. However, one category has remained largely unexplored: fully aromatic-substituted polymethylenes bearing functional groups on every backbone carbon. These polymers represent the densest functionalization achievable in ... |
41773463 | Diamine Grafting of Pyrazole-Based MOF-303 for Diluted-Source CO<sub>2</sub> Capture. | Amine-functionalized materials have been extensively investigated for CO<sub>2</sub> capture, with adsorption mechanisms based primarily on carbamate formation. Among the different strategies, grafting amine moieties onto porous solid supports represents a benchmark approach for developing highly effective adsorbents, ... |
41773411 | Going Deep into the Surface Chemistry of Carbon Dots: Influence of Functional Groups on the Redox Abilities. | Carbon dots (CDs) are emerging nanomaterials with low-cost synthesis and highly tunable surface chemistry, which have propelled their widespread use in catalysis and photocatalysis. Yet, unraveling their chemical structure remains essential to unlocking their full potential. Here, we systematically investigated the red... |
41773331 | Block Copolymer-Enabled Low-Temperature Structural Battery Electrolytes Produced Using Polymerization-Induced Phase Separation. | Structural battery electrolytes (SBEs) require both high ionic conductivity and high mechanical strength and stiffness. However, SBEs produced using the one-pot polymerization-induced phase separation (PIPS) synthesis method suffer from high tortuosity which decreases the effective ionic conductivity. Additionally, con... |
41773315 | Targeted metabolic glycoengineering using multivalent mannosyl metal-organic frameworks (MOFs). | Cell-type selective metabolic labeling of glycans in complicated biological environments remains a big challenge. Herein, we develop a glycan labeling tool by encapsulating a non-natural azido sugar (ManNAz) into a mannosyl ligand-modified metal-organic framework (MOF) (MIL-101-Man). The mannosyl ligands multivalently ... |
41773051 | Nanoparticulate protectants for the dry storage of protein therapeutics. | Protein therapeutics are a cornerstone of modern medicine, yet their inherent instability often requires expensive and energy-intensive cold-chain logistics to maintain efficacy. Dry-state formulations offer a viable strategy to enhance protein stability, but the associated drying processes, such as lyophilization and ... |
41773050 | The Complex Formation Mechanism between β-Cyclodextrin and Organic Micropollutants in Water, Studied by Molecular Dynamics Simulations. | Cyclodextrins are cage molecules with a hydrophilic exterior that promotes their solubility in water, while their hydrophobic cavity allows the encapsulation of low-molecular-weight organic molecules. Thus, cyclodextrin is a promising compound for removing micropollutant molecules from water. The binding mechanism of l... |
41773039 | Structural insights of <i>mycobacterial</i> ATP synthase and recent updates on molecular recognition of <i>Mtb</i> ATP synthase inhibitors: a review. | In <i>mycobacteria</i>, the F<sub>1</sub>Fo-ATP synthase enzyme comprises five polypeptide chains (Chain <b>α, β, γ, ε, δ)</b> and three subunits (Subunit <b>a</b>, <b>b</b>, and <b>c</b>), respectively. ATP is fundamental for the survival and growth of <i>mycobacterial strains</i>. In tuberculosis, this enzyme survive... |
41772644 | Bakuchiol-loaded amphiphilic polymeric nanoparticles: enhancing stability and multifunctionality through encapsulation. | Bakuchiol (BK), a natural meroterpene isolated from Psoralea corylifolia, has gained significant attention as a functional cosmetic ingredient due to its antioxidant, anti-inflammatory, and antibacterial properties. However, its high hydrophobicity and chemical instability limit its practical application. In this study... |
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