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41273744 | An italian multicenter triple-blind randomized controlled trial on photobiomodulation after third molar extraction (BIOSTOTT). A study of italian society for laser in dentistry (SILO). | <h4>Background</h4>Surgical extraction of third molars is a common oral and maxillo-facial surgery procedure frequently associated with postoperative complications, such as pain, swelling, and trismus. Photobiomodulation (PBM), also known as Low-Level Laser Therapy (LLLT), involves the use of low-intensity laser to pro... |
41264461 | ChemR23 prevents phenotypic switching of vascular smooth muscle cells into macrophage-like foam cells in atherosclerosis. | <h4>Aims</h4>Haematopoietic ChemR23 deficiency was shown to reduce atherosclerotic lesions by increasing M2 macrophages, but conflicting results in systemically deficient mice suggest a cell-specific function of ChemR23. Therefore, we aimed to study the role of ChemR23 particularly on vascular smooth muscle cells (VSMC... |
41206468 | How Duffy Blood Group (FY) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon. | <h4>Background</h4>A promoter variant commonly found in sub-Saharan Africans and their descendants disrupts Duffy antigen (Fy) expression on erythrocytes, leading to the Fy-negative phenotype, and confers partial resistance to blood-stage Plasmodium vivax infection. In addition, the 125G→A substitution, rare in African... |
41165465 | Acquired High Tumor Mutational Burden and Activity of Immunotherapy after Targeted Therapy in Microsatellite Stable Colorectal Cancer. | <h4>Purpose</h4>Microsatellite stable (MSS) colorectal cancers, in contrast to microsatellite instability-high colorectal cancers, have few mutations and are insensitive to immune checkpoint blockade (ICB). Colorectal cancers treated with targeted agents often acquire a high number of genomic alterations at progression... |
41106822 | Antifracture Efficacy of 5- or 10-Yearly Zoledronate in Women Aged 50 to 60 Years: Secondary Analyses of a Randomized Trial. | <h4>Context</h4>We recently reported that zoledronate (zol) given once at baseline or twice (every 5 years) reduced fracture risk over 10 years.<h4>Objective</h4>We assessed whether the effects of zol differ over time or across important baseline variables, and how they relate to changes in bone mineral density (BMD) o... |
41084837 | Dabogratinib (TYRA-300), an FGFR3 Isoform-Selective Inhibitor: Preclinical and Initial Clinical Evidence of Antitumor Activity. | Despite recent advances in the treatment of fibroblast growth factor receptor 3 (FGFR3)-altered metastatic urothelial carcinoma, there is no approved precision therapy that selectively targets FGFR3 while sparing other FGFR isoforms. Dabogratinib (TYRA-300)-a rationally designed selective FGFR3 inhibitor-was evaluated ... |
40926519 | Seeds and nanomaterials: seed-assisted synthesis, nanotoxicity, and seed-associated nanotechnology innovations. | Seeds are the cornerstone of agricultural crop production. They are sources of many valuable materials that can be used to convert bulk materials into nanoforms, thus supporting sustainability in nanomaterial (NM) synthesis and circular farming. The use of seeds in innovative nanotechnology is based on the theoretical ... |
40855912 | Mental health issues, risks and barriers to care for Bangladeshi children and adolescents: insights from lived experiences. | <h4>Background</h4>Mental health issues among Bangladeshi children and adolescents are increasing due to sociocultural factors. Despite its importance, in-depth research is scarce. This study addresses the gap by exploring mental health issues, risk factors and barriers to accessing care in rural and urban Bangladesh t... |
40795306 | In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the death of both upper and lower motor neurons. Approximately 20% of familial ALS cases are associated with mutations in the superoxide dismutase type 1 (SOD1) gene. Developing a specific strategy to characteristically silence the pat... |
40163898 | Recent Developments and Future Perspectives in Magnetic Resonance Imaging and Computed Tomography Contrast Media. | <h4>Abstract</h4>This review provides a comprehensive analysis of recent advancements in computed tomography (CT) and magnetic resonance imaging (MRI) contrast media, offering a critical evaluation of current trends and exploring future directions in the field. New clinical developments within the last 5-8 years are co... |
42006331 | Microwave-induced energy activation: Mechanisms and material advances. | Microwave ignition is an emerging non-contact energy activation technique offering rapid response, selective heating, and high controllability compared with conventional ignition. Owing to volumetric energy deposition and localized field enhancement, it has attracted growing interest in energetic materials activation a... |
41943381 | Hyaluronic acid-based supramolecular peptide-drug conjugate prodrug nanosystems for precise multiple myeloma therapy. | Multiple myeloma (MM) is an incurable hematological malignancy with excessive bone marrow infiltration and pro-inflammatory microenvironment. In clinical practice, melphalan, an alkylating agent, and dexamethasone, a glucocorticoid widely used in MM regimens, provide clinical benefits. However, their efficacy is still ... |
41938137 | Hepatic cavernous hemangioma decellularized extracellular matrix/GelMA composite hydrogel promotes angiogenesis via the ITGA9-FAK-ERK1/2 axis. | Effective angiogenesis is crucial for tissue engineering and regenerative medicine. However, current strategies such as growth factor or endothelial cell (EC) delivery often face challenges in inducing stable and efficient vascularization. Inspired by mimicking matrix composition and physical architecture of vascular h... |
41918921 | Crystalline Porous Materials for Lithium Extraction. | The rapid transformation of the global energy structure has promoted the broad application of lithium-ion batteries. The efficient extraction of lithium, which is a core raw material for lithium-ion batteries, has become a crucial step in the new energy sector. Crystalline porous materials (CPMs) with distinct chemical... |
41902201 | Alpha-Glucosidase of <i>Manduca sexta</i> Is an Entry Factor for <i>Daphnis nerii</i> Cypovirus-23. | <i>Daphnis nerii</i> can severely damage pine forests worldwide. <i>Daphnis nerii</i> cypovirus-23 (DnCPV-23) is an important viral pathogen for controlling <i>D. nerii</i>. However, the mechanism underlying DnCPV-23 cell entry has not been elucidated. In this study, we determined that VP3 mediates the binding of DnCPV... |
41901245 | Topical Polyherbal Phytopreparation Reduces Gingival Inflammation: Evidence from a Randomized Controlled Clinical Study Supported by In Silico Analysis. | <b>Background</b>: Numerous plant-derived products have shown notable potential in preclinical studies and traditional use for the management of periodontitis, although clinical studies validating their efficacy remain scarce. The present study investigated the efficacy of a polyherbal phytopreparation as an adjunctive... |
41901238 | Formulation Matters: The Overlooked Engine of Stability and Success in Antibody-Drug Conjugates. | <b>Backgrounds:</b> Antibody-drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the cytotoxic potency of drugs, representing a significant class of targeted cancer therapeutics. Despite their clinical success, formulation-related instability, rather than biological inefficacy, is a major contr... |
41901234 | In Silico Discovery of ABZI Nitrogen Heterocycle STING Agonists via 3D-QSAR, Molecular Dynamics, and AI-Based Synthesis Prediction. | <b>Background/Objectives</b>: The stimulator of interferon genes (STING) pathway plays a central role in innate immune signaling and represents an attractive therapeutic target for cancer immunotherapy. Amidobenzimidazole (ABZI) derivatives have emerged as promising non-nucleotide STING agonists with improved drug-like... |
41900797 | [<sup>161</sup>Tb]Tb-BPAMD as a High-Affinity Agent for Skeletal Targeting: Radiochemical and Biodistribution Insights. | <b>Background</b>: Bone-seeking radiopharmaceuticals based on bisphosphonates enable targeted therapy of skeletal metastases. They are suitable carriers for therapeutic radionuclides such as terbium-161 (<sup>161</sup>Tb), a β<sup>-</sup> emitter that additionally releases short-range conversion and Auger electrons, wh... |
41900795 | Tailoring Syringic Acid-Trimesic Acid Mixed-Linker MIL-100(Fe): Evaluation of Drug-Loading Capacity, Bioavailability, and Toxicity. | <b>Background/Objectives:</b> The use of the drug delivery system is notable for the systemic improvement of low orally bioavailable compounds, such as the bioactive phenolic acid, syringic acid. Innovative techniques are employed to enhance the performance of certain drug delivery systems. In connection with our previ... |
41900791 | Cyclodextrins as Modulators of Regulated Cell Death: Implications for Immunometabolism and Therapeutic Innovation. | This review critically examines how cyclodextrins modulate regulated cell death pathways and the implications for immunometabolism and therapeutic translation. Increasing evidence, however, indicates that cyclodextrins exert intrinsic biological activity by modulating cellular lipid homeostasis, membrane organization, ... |
41900789 | From Inclusion Complexes to Innovative Therapies: Cyclodextrins and Their Pharmaceutical Applications. | Originally discovered over a century ago, cyclodextrins (CDs) have evolved from biochemical curiosities into indispensable enablers of modern drug delivery [...]. |
41900790 | Development of DNA Aptamers Against <i>Leishmania infantum</i> GP63 Protein for Therapeutic and Diagnostic Applications. | <b>Background/Objectives:</b> Leishmaniasis is a disease affecting millions of people caused by parasites of the genus <i>Leishmania</i>. The GP63 protein of <i>Leishmania infantum</i> (<i>Li</i>GP63) is one of its major surface antigens and a main virulence factor, playing a role in the adhesion of extracellular proma... |
41900794 | Advanced Optimization of Clonazepam-Loaded Solid Self-Emulsifying Drug Delivery Systems: Comparison of Weighted Goal Programming and Desirability Function in a Quality by Design Framework. | <b>Background/Objectives:</b> Clonazepam (CLZ), a BCS Class II drug, presents significant oral delivery challenges due to its low aqueous solubility. This study explores the systematic development of solid self-emulsifying drug delivery systems (S-SEDDS) using Quality by Design (QbD). The primary objective was to evalu... |
41900317 | Mechanistic Insights into the Inhibition of <i>Yersinia enterocolitica</i> Biofilm Formation by Lipoic Acid. | <i>Yersinia enterocolitica</i> is a foodborne pathogen that forms biofilms on surfaces, enhancing its survivability and increasing bacterial resistance, which poses a significant challenge to public health. Therefore, developing effective strategies to inhibit biofilm formation is crucial. Lipoic acid (LA) is a compoun... |
41900192 | Stimuli-Responsive Nanomaterial-Based Biosensor Structures for Wound Care: pH, ROS, and Temperature Sensing Strategies. | Chronic and infected wounds remain a major clinical challenge due to their dynamic microenvironments and the lack of real-time diagnostic feedback in conventional dressings. Recent advances in stimuli-responsive nanomaterial-based biosensors have enabled the development of smart wound-care systems capable of continuous... |
41899823 | The Application of Polyrotaxane Cellulose Composite Materials in Quasi-Solid Electrolytes. | Due to its affordability, widespread availability, non-toxicity, biodegradability, and renewability, cellulose is considered a crucial material for addressing the depletion of petroleum resources. In this study, a rotaxane-based supramolecular polymer derived from thermoplastic polyurethane (TPU) was synthesized and co... |
41899821 | Advancements in Bio-Based Piezoelectric Composites for Antibacterial Applications. | Mechanical energy, a ubiquitous renewable resource, can be effectively harnessed via piezocatalysis to convert physical stimuli into chemical energy for sterilization. As a promising green technology, piezocatalysis employs external mechanical force to physically disrupt bacterial membranes while simultaneously trigger... |
41898919 | Functional Characterization of OasiCSP12: A Chemosensory Protein Regulating Olfaction and Phase Change in <i>Oedaleus decorus asiaticus</i>. | The Asian migratory locust (<i>Oedaleus decorus asiaticus</i>) is a major grassland pest in northern China, with outbreak dynamics closely linked to phase transition mediated by chemical communication. This study focused on a chemosensory protein, OasiCSP12, to explore its potential role in this process. We analyzed it... |
41897297 | Tranexamic Acid-Associated Hyaluronic Acid Exhibits Enhanced Oxidative Stability: A Comparative Rheological Study. | <b>Background:</b> The clinical performance of intra-articular hyaluronic acid (HA) is strongly dependent on its resistance to oxidative degradation within the inflamed osteoarthritic joint. Reactive oxygen species induce HA chain scission, leading to a loss of molecular entanglement and a shift from elastic-dominant t... |
41893763 | From Innate to Adaptive: Paradigm Shifts and Frontier Challenges in Next-Generation Vaccine Design. | The unprecedented success of mRNA vaccines during the COVID-19 pandemic marks a fundamental paradigm shift in vaccinology, moving the field from empirical pathogen modification toward the rational engineering of host immunity. This review synthesizes recent breakthroughs to construct a conceptual framework for understa... |
41893315 | Chemical Signaling and Metabolomic Crosstalk in Endophytic Fungi-Medicinal Plant Symbioses for Natural Product Discovery and Sustainable Bioproduction. | <b>Background:</b> Medicinal plants function as complex holobionts, with their therapeutic potential significantly shaped by the associated microbiome, particularly endophytic fungi. These symbionts engage in a sophisticated "chemical signaling" with their hosts, acting as biotic elicitors that modulate plant secondary... |
41893275 | Recent Advances in Stimuli-Responsive Membranes: From Supramolecular Design to Controlled Permeability. | Stimuli-responsive liposomal membranes have attracted growing interest as dynamic soft materials capable of regulating permeability, fusion, and cargo release in response to external or internal triggers. By incorporating functional molecular or nanostructured guests, such as photochromic compounds, plasmonic nanoparti... |
41893273 | Synergistic Interfacial Design of Cation Exchange Membranes via Sequential Electro-Assembly for High-Efficiency Lithium Separation. | The industrial application of modified ion-exchange membranes is limited by complex, discontinuous ex-situ processes. This study introduces an in-situ electro-assembly strategy that enables the direct fabrication of a selective layer within an electrodialysis stack without disassembly. By utilizing a programmed current... |
41892524 | Optical Sensing Properties of New Innovative Materials: Interaction of Photoactive Copolymers with Fluorescent Nanoparticles to Create Light-Sensitive Hydrogel Films. | This work investigates the use of two photoactive polymers, functionalized with quantum dots (QDs) (ZnS and CdTe/ZnS), to develop optical sensing hydrogel films through their interactions. It examines their responses to light stimulation for potential biological applications. The optical and morphological properties of... |
41892076 | Defining Histological Patterns in Inherited Ichthyoses: Toward a Diagnostic Algorithm Based on 66 Confirmed Cases. | <h4>Background</h4>Inherited ichthyoses are a heterogeneous group of disorders of cornification caused by mutations in genes encoding epidermal proteins. Clinically, patients with ichthyosis present with erythema, scaling, and occasionally blistering; some subtypes are syndromic. Accurate and timely diagnosis is essent... |
41892033 | The Synthesis of Ru-Co-Oxalate MOFs for an Electrochemiluminescent Glyphosate Sensor. | Cobalt-ruthenium bypiridine-oxalate metal-organic frameworks (MOFs) were synthesized via a solvothermal method with a custom-designed reactor that permits stirring, which can result in changes in the morphology of the structures. In this work, we performed a morphological and structural study of MOFs with varying tris(... |
41864180 | Molecular dynamics insights into the selective adsorption of biogenic amines by a crosslinked β-cyclodextrin-citric acid polymer. | Crosslinked cyclodextrin (CD)-based polymers, particularly those formed with citric acid (CA), have demonstrated promising potential for the adsorption of polar trace contaminants due to their environmentally benign nature and tunable physicochemical properties. In this study, we developed a molecular model of a crossl... |
41859647 | Grafts in tendon repair. | Inferior healing after tendon rupture often necessitates the use of grafts to reinforce tendon repair and promote the regeneration of functional tissue. Autograft or allograft implantations are considered the gold standard in tendon reconstruction, though these types of treatment may not always be feasible due to limit... |
41858618 | Unraveling the complexities: A comprehensive review of severe fever with thrombocytopenia syndrome and its associated complications. | Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus (DBV), is an emerging vector-borne infection with significant global health implications, particularly in East Asia. In recent years, its geographic footprint has expanded beyond traditional endemic regions, raising global concern due to hig... |
41850320 | Effects of Various Anti-Diabetic Drugs on the Risk of Fractures in Older Women with Type 2 Diabetes Mellitus. | <h4>Background</h4>To investigate the fracture risks associated with anti-diabetic drugs in older women with type 2 diabetes mellitus (T2DM), who are particularly susceptible to skeletal fragility.<h4>Methods</h4>Using data from the Korean National Health Insurance Service, this nested case-control study included 10,10... |
41829772 | Mulberry Drought Diagnosis: Integrating Proximal Sensing and Metabolomics for Remote Monitoring. | Drought is the most severe natural hazard threatening agricultural production. Mulberry (<i>Morus alba</i> L.) is an important crop for the sericulture industry, and its drought tolerance has been extensively studied. In this study, the phenotypic and physiological responses of two different mulberry tree genotypes (71... |
41828810 | Investigation of Sr<sup>2+</sup> Extraction from Aqueous Phase Using Novel Diglycolamide/Ionic Liquid System. | Obtaining high-purity <sup>90</sup>Sr is crucial because it is the parent radionuclide of the <sup>90</sup>Sr/<sup>90</sup>Y generator. However, <sup>90</sup>Sr products recovered from high-level liquid waste (HLLW) often fail to meet the stringent purity requirements. This necessitates the development of a novel extra... |
41828808 | Galloylation-Driven Anchoring of the Asp325-Asp336 Ridge: The Molecular Logic Behind the Superior Kinetic Stabilization of HMPV Fusion Protein by Green Tea Dimeric Catechins. | The human metapneumovirus (HMPV) Fusion (F) glycoprotein is a high-priority target for "fusion-locking" agents that stabilize its metastable prefusion state. While monomeric catechins like EGCG are known antivirals, the molecular basis for the superior activity of structurally complex dimeric catechins remains poorly u... |
41823765 | Recent Advances in Metal Phthalocyanine for Sensing Applications. | In recent years, metal phthalocyanine (MPc)-based sensors have garnered significant interest for applications in environmental monitoring, biomedical diagnostics, and industrial process control, owing to their efficient and cost-effective sensing capabilities. In contrast to conventional inorganic materials, MPcs are a... |
41816651 | Focus on the role of mixed micelles and lipid droplets in the oxidative stability of oil-in-water emulsions using size distribution Taylor dispersion analysis. | This study investigates the role of mixed micelles and lipid droplets in the oxidative stability of oil-in-water emulsions using Size Distribution - Taylor Dispersion Analysis. Tween surfactant facilitates the formation of mixed micelles containing surface-active components in non-stripped oils, whereas oil stripping s... |
41780403 | Tape-assisted nanoplasmonic biosensors for facile protein-on-chip visualization and multiplexed point-of-care diagnostics. | Visual point-of-care testing (POCT) technologies convert biomolecular events into naked-eye readable signals. These systems offer rapid assay times, user-friendly operation, and eliminate the need for specialized instruments, making them particularly valuable for clinical diagnosis, public health emergency response, an... |
41773219 | Quercetin and Its Nano-Based Formulations Against Skin Cancer: A Narrative Review. | <h4>Background</h4>Skin cancer is one of the most prevalent malignancies worldwide, characterized by the abnormal growth of skin cells and significant clinical challenges. Conventional treatments-including surgery, chemotherapy, and radiotherapy-often suffer from limitations such as adverse side effects, tumor resistan... |
41771389 | A thermoresponsive spray-based no-contact delivery system for burn and diabetic wound care. | No-contact drug delivery to burn and diabetic wounds remains a major challenge despite advancements in surgical dressings and technology. To address this, a smart polymer-based system containing Asiatic acid and curcumin was selected for its complementary wound-healing properties. Curcumin offers anti-inflammatory and ... |
41771307 | Optimizing spray-dried liposomes for pulmonary delivery: impact of lipids composition and of drying parameters using experimental design. | Liposomes are promising carriers for pulmonary drug delivery due to their biocompatibility and controlled-release properties. However, their stability in aqueous suspension is limited, leading to aggregation and reduced therapeutic efficiency. Converting liposomal dispersions into dry powders for inhalation (DPIs) is a... |
41765335 | Prophylactic sequential drug administration potentiates cancer radiotherapy by inhibiting cholesterol deposition and cellular senescence. | Radiotherapy serves as a mainstream cancer therapy modality, while the adaptive resistance induced by ionizing radiation (IR) hampers the therapeutic efficacy. Among various factors underlying radioresistance, lysosomal cholesterol deposition and cellular senescence emerge with complicated interrelation, leaving unclea... |
41764534 | Spatial phosphoproteomics reveals regional phosphorylation features in liver cirrhosis progression. | <h4>Background</h4>Liver cirrhosis (LC) is the end stage of chronic liver disease and is characterized by pseudolobule formation and extensive fibrosis. Protein phosphorylation, a key posttranslational modification, regulates cellular functions and disease progression. However, the dynamic changes in phosphorylation ac... |
41764495 | 3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration. | A multifunctional polysaccharide-based hydrogel was developed for liver regeneration by integrating sodium alginate (SA), sodium lignosulfonate (SL), and 3D bioprinting technology. The hydrogel incorporated FH1@SA microspheres and CaO<sub>2</sub>@ZIF-8@SL nanoparticles to reconstruct the hepatic microenvironment throug... |
41764355 | Anthraquinones derived from soil actinomycetes combat multidrug-resistant Staphylococcus aureus. | The global spread of multidrug-resistant Staphylococcus aureus (MRSA) poses serious threats to public health and food safety. In this study, the antibacterial potential of the anthraquinone compound 13394-2, derived from soil actinomycetes, was systematically evaluated. In vitro, 13394-2 exhibited potent activity (MIC ... |
41764282 | Design of benzo[1,2-b:4,3-b']dithiophene-4,5-dione based donor-acceptor-donor small molecules for efficient near-infrared photothermal therapy. | The development of high-performance organic photothermal conversion agents (PTCAs) with strong near-infrared (NIR) absorption, high photothermal conversion efficiency (PCE), and excellent biocompatibility remains a critical challenge in photothermal therapy (PTT). In this study, we designed and synthesized a series of ... |
41764271 | Pyrogallol B-ring enhances catechin binding to the SARS-CoV-2 spike receptor-binding domain to inhibit interaction with ACE2. | Severe acute respiratory syndrome coronavirus 2 infects host cells through binding of the spike protein receptor-binding domain (RBD) to the human angiotensin-converting enzyme 2 receptor. In this study, the antiviral activity of 14 catechin derivatives was evaluated using a pseudovirus assay that emulates spike-mediat... |
41764255 | SARS-CoV-2 nucleocapsid protein-specific monoclonal antibodies as tools for studying its antigenic structure and interaction with host cells. | Diagnostics and prevention of COVID-19 are essential for controlling the spread of the virus and reducing mortality rates. As SARS-CoV-2 surface proteins are susceptible to mutations, the nucleocapsid protein (NP) with its highly conserved gene sequence is an attractive target for studying virus-host interactions. NP p... |
41764243 | Topology-controlled dynamic conjugated oligomers from tetra-arylsubstituted alkene building blocks. | Topology plays an important role in polymeric materials. Herein, we present an iterative, modular approach for creating tetra-arylsubstituted alkene (TAA)-based dynamic conjugated oligomers with diverse topologies, using boronate-protected Suzuki-Miyaura coupling chemistry. The TAA building blocks involving spontaneous... |
41764224 | Template-directed vertical photopolymerization for construction of triphenylamine-based poly(diacetylene) nanofibers. | Template-directed synthesis of macromolecules prevails in natural systems. However, artificial template-directed covalent polymerization that proceeds without sacrificing the delicate non-covalent order needed for precursor alignment remains a formidable challenge. Here we report a supramolecular-templating strategy fo... |
41764162 | Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10/ubiquitin thioester transfer. | UBA1 and UBA6 define parallel ubiquitin (Ub) activation systems that perform non-overlapping roles in Ub and ubiquitin-like protein (Ubl) signaling. Whereas UBA1 supports the canonical Ub pathway, UBA6 also activates the Ubl FAT10, linking Ub signaling to immune-regulated proteostasis. In addition to selective Ub/Ubl a... |
41762713 | <i>para</i>-Donor Effects in PyNO Push Ligands Control O-O Bond Cleavage of TPAFe(III)-Acylperoxo to High-Valent Fe(IV)═O or Fe(IV)═O Radical Cation Species. | Selective O-O bond cleavage in nonheme Fe(III)-OOR complexes supported by tetradentate N<sub>4</sub> ligands has long been challenging. Here we show that <i>para</i>-donor-substituted pyridine <i>N</i>-oxides (PyNOs) act as powerful external push ligands that direct Fe(III)-acylperoxo intermediates toward homolysis or ... |
41762712 | Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation. | Natural and artificial enzymes have emerged as promising candidates for biomedical applications, possessing the potential to address redox imbalances and metabolic disorders in liver diseases. However, their clinical translation remains limited by challenges in biocompatibility, targeted delivery, dose-response balance... |
41762707 | Surface Engineering on Transition Metal Dichalcogenides: In Situ Encapsulation of Metal-Organic Frameworks for Highly Humidity-Resistant Gas Sensing at Room Temperature. | For their large specific surface areas and strong affinity with water molecules, two-dimensional (2D) material-based gas sensors are highly susceptible to the inference of ubiquitous relative humidity (RH) fluctuance, resulting in reduced accuracy and poor stability in real-world conditions. In this study, a metal-orga... |
41762693 | Disaccharide-Presenting Iron(II) Complexes as Synthetic Mimics of Natural Glycan Epitopes for Lectin Recognition. | Carbohydrates present on the surface of living cells mediate key biological processes, including viral infection, cell adhesion, and immune response. Mimicking the structural complexity of these naturally occurring sugars is therefore critical for gaining fundamental insights into protein-carbohydrate recognition and f... |
41762371 | Mid-Infrared Transparent Materials: from Mechanisms to Cutting-Edge Applications. | The mid-infrared (MIR) spectral window, typically spanning wavelengths from 2.5 to 20 μm (or wave numbers 500-4000 cm<sup>-1</sup>), constitutes a pivotal domain of the electromagnetic spectrum, where molecular vibrational and rotational transitions enable precise spectroscopic identification and tunable thermal radiat... |
41762234 | Gene mapping and identification of candidate genes associated with fomesafen herbicide tolerance in Mung bean (Vigna radiata L.). | <h4>Key message</h4>Through an integrated approach of genetic mapping, transcriptomics, and functional validation, we identified VrGSTU18 as the primary gene associated with fomesafen resistance in mung bean, providing a genetic resource for breeding herbicide-resistant varieties. Herbicides are widely applied for weed... |
41762134 | Mixed-Valence Cu<sup>I</sup>/Cu<sup>II</sup>-Eu<sup>III</sup> Heterometallic Framework for the Synthesis of α-Alkylidene Cyclic Carbonates from Flue Gas-Level Dilute CO<sub>2</sub>. | The preparation of α-alkylidene cyclic carbonates through a cyclization reaction of propargylic alcohols with CO<sub>2</sub> is important in the industrial process. Herein, a novel mixed-valence heterometallic Cu/Eu-based cationic framework, <b>1-Eu</b>, was successfully synthesized. The material features a unique 14 Å... |
41762071 | Component-Programmed Self-Assembly for Topological Transformation: From a 2D Network to a Discrete Star of David. | Controllable modifications on dimensionalities and topologies of supramolecules are crucial for tuning their properties. Here, we report a robust component-controlled topological transformation, initiating with a two-dimensional (2D) layered coordination network S2 formed by the self-assembly of a metallo-organic ligan... |
41762072 | Silk Fibroin-Modified Metal Organic Framework Acid-Controlled Release Nanocarrier for Polyetheretherketone to Combat Implant-Associated Infections and Promote Angiogenesis. | Polyetheretherketone (PEEK) has been regarded as a prospective alternative orthopedic implant, because of its elastic modulus approximately equal to human cortical bone. However, the poor antibacterial and angiogenic properties of bioinert PEEK have become a limitation to its clinical application. Therefore, a biomimet... |
41762042 | High-Performance Ultra-Narrowband Blue Electroluminescence via Intramolecular Noncovalent Interaction-Enhanced Multiple Resonance Emitters. | The development of high-performance blue organic light-emitting diodes (OLEDs) is impeded by the scarcity of molecular scaffolds for ultranarrow multiple-resonance thermally activated delayed fluorescence (MR-TADF) emitters and their inherent tendency to suffer from aggregation-induced broadening and quenching in solid... |
41761747 | The 10-23 DNAzyme in Biosensing and Diagnostics: Applications, Challenges, and Future Directions. | Catalytic DNA molecules (DNAzymes) have garnered increasing attention as components of biosensing and diagnostic platforms due to their simplicity, programmability, and cost-effectiveness. Among them, the 10-23 DNAzyme remains the most widely used RNA-cleaving DNAzyme, combining high catalytic efficiency with broad ada... |
41761460 | Aromatic Interactions Select for Homodimeric Assembly in a Quadruply Hydrogen-Bonded DADA 1,2-Azaphosphinine Dimer. | Inclusion of a fused pyridine ring onto the core motif of an azaphosphinine heterocycle, as well as functionalization with an <i>N</i>-acetamide group, furnishes a chiral, quadruple hydrogen bonding face that is capable of strong homodimerization. Eleven different azaphosphinine derivatives were prepared with variable ... |
41761292 | Engineered chitosan/HP-β-CD hydrogel for targeted co-delivery of curcumin and berberine for the treatment of ulcerative colitis. | Ulcerative colitis (UC) presents considerable challenges in clinical treatment due to its multifaceted and complex nature. Efficacious therapy technique in developing an oral formulation that can encapsulate and deliver therapeutic drugs directly to the colon to diminish intestinal inflammation and restore the impaired... |
41761256 | The utilization of activated carbon derived from polyethylene terephthalate bottle waste, as a sustainable source for removal and recovery of methylene blue and picric acid from aqueous solutions. | In this study, waste polyethylene terephthalate (PET) from discarded bottles was recycled via KOH treatment to produce activated carbon (AC) to remove methylene blue (MB) and picric acid (PA) from contaminated water. The AC produced was characterized by using physicochemical methods to assess its surface porosity, morp... |
41760870 | Structurally-optimised HPV16 E7/E6 mRNA-LPP mediates dose-sparing efficacy via tumour microenvironment reprogramming. | The development of therapeutic vaccines against human papillomavirus (HPV)-associated malignancies remains challenging due to the immunosuppressive tumour microenvironment and the limited efficacy of existing delivery platforms. In this study, we designed and systematically compared two mRNA vaccine strategies based on... |
41760685 | Coordination restraint of Rh-Cu diatomic catalyst and C-H bond oxygen insertion for methanol synthesis. | Direct oxidation of methane to methanol is valuable, but reactive oxygen species over oxidize methane and lower selectivity. Here we report a Rh-Cu heteronuclear dual atom catalyst on nitrogen doped graphite that separates sites and restrains oxygen intermediates, enabling methanol through oxygen insertion into C-H bon... |
41760650 | Hybrid macrophage-mitochondria extracellular vesicles for mitochondrial ROS regulation in diabetic wounds. | Precise regulation of mitochondrial reactive oxygen species (mtROS) in macrophages is essential for reducing inflammation and promoting diabetic wound healing. However, achieving targeted and responsive mtROS modulation in specific cell remains challenging. Herein, we report a macrophage-mitochondria hybrid membrane de... |
42006157 | An exosome-inspired docetaxel prodrug nanoplatform for potent STING activation and synergistic chemoimmunotherapy. | The treatment of triple-negative breast cancer (TNBC) is significantly hampered by its immunosuppressive tumor microenvironment and limited T-cell infiltration. Activating the STING pathway presents a promising therapeutic avenue due to its potential to trigger a robust innate immune response and remodel the immunosupp... |
41993699 | Progress in siRNA therapy and delivery platforms for osteoarthritis. | Osteoarthritis (OA) is driven by a cycle of cartilage decay, synovial inflammation, and bone remodeling. This progression is fueled by the self-perpetuating synergy between matrix-degrading enzymes and pro-inflammatory cytokines, posing a formidable barrier to effective therapy. Small interfering RNAs (siRNAs) offer a ... |
41969465 | Study on the inhibition of thyroid undifferentiated carcinoma metastasis by nanoparticles loaded with EZH2 inhibitor. | <h4>Background</h4>Anaplastic thyroid carcinoma (ATC) is highly malignant with a poor prognosis. Current treatment methods fail to prolong patients' survival periods, and there is an urgent need to explore new strategies. EZH2 is highly expressed in ATC, and its inhibitors EPZ6438 and GSK343 have anti-cancer potential.... |
41948127 | Safety, efficacy, and distal nerve Schwann cell biodistribution in mice and NHPs to support translation of AAV9 RNAi therapy for CMT1A. | Charcot-Marie-Tooth (CMT) type 1A, the most common inherited demyelinating peripheral neuropathy, is caused by PMP22 gene duplication, leading to overproduction of PMP22 protein in Schwann cells. To treat CMT1A, we developed a PMP22 gene silencing therapy using adeno-associated viral vectors (AAV9) to deliver a therape... |
41943375 | Hierarchical assembly and digestive resistance of starch-unsaturated fatty acid complexes regulated by ultrasound-assisted high-pressure microfluidization. | This study elucidates how dynamic high-pressure microfluidization (DHPM) synergistically combined with ultrasound (US) pretreatment regulates the molecular assembly, hierarchical structure, and in vitro digestive behaviors of starch-unsaturated fatty acid (UFA) complexes. Fully gelatinized wheat starch (WS) was complex... |
41902199 | Identification of Receptor Binding Proteins of <i>Yersinia</i> Phage φR1-37 and Enterocoliticin That Use the Same Bacterial Surface Receptor. | The bacterium <i>Yersinia enterocolitica</i> serotype O:3 is targeted by two distinct agents, the bacteriophage φR1-37 and the bacteriocin-like enterocoliticin (a tailocin), which both utilize the lipopolysaccharide (LPS) outer core (OC) hexasaccharide as their primary host receptor. In order to understand this converg... |
41902193 | Molecular Ruler Variation in Insect Dicer-2 Suggests a Structural Basis for Species-Dependent siRNA Length and Antiviral Defense Diversity. | Understanding species-dependent siRNA length generation provides both fundamental and applied insights. At the basic level, it highlights an underappreciated dimension of RNAi diversity in insects, emphasizing that antiviral immunity cannot be fully understood from <i>Drosophila melanogaster</i> alone. At the applied l... |
41901220 | Ticagrelor-Loaded Phospholipid-Polyoxyethylene Hybrid Nanocarriers: Enhanced Solubility and Efficacy Against SARS-CoV-2. | <b>Background</b>: SARS-CoV-2 poses significant global health challenges, necessitating effective antiviral strategies. Ticagrelor, an FDA-approved antiplatelet drug, has shown potential against SARS-CoV-2 but suffers from low solubility and bioavailability. This study aims to develop and characterize ticagrelor-loaded... |
41900308 | Effects of Alfalfa Fiber Meal on the In Vitro Fermentation Characteristics and Community Structure of the Colonic Microbiota of Sows. | The gut microbiota plays a critical role in hindgut health and nutrient utilization in monogastric animals. Alfalfa fiber meal (AFM) was rich in essential vitamins and minerals as a valuable nutritional supplement. In this study, an in vitro fermentation model was established using fecal microbiota from pregnant sows a... |
41898181 | From Selection to Use: Aptamers as Targeting Reagents in Hematology. | Aptamers are synthetic nucleic acid ligands that have been proposed as alternatives to antibodies for targeting molecules and cells. In hematology, most reviews have organized aptamer literature around diseases or technological platforms. This framing has obscured how unevenly different blood cell types have been cover... |
41893752 | Research Progress Towards Poliovirus Virus-like Particle Vaccines: A Review. | Poliovirus (PV), a historically significant enterovirus responsible for severe paralytic diseases, has seen its incidence dramatically reduced through widespread vaccination efforts, propelling global eradication initiatives. Despite the success of traditional oral poliovirus vaccines (OPVs) and inactivated poliovirus ... |
41892522 | Comparison of NaOH-Based Solvents for Lignocellulosic Microfines (LCMFs) Dissolution and Properties of Regenerated Cellulose Film. | Cellulose dissolution solvents have been developed for the fabrication of regenerated cellulose (RC) films, which are known for their high optical transparency, excellent barrier properties, and biodegradability. In this study, three types of aqueous dissolution systems, including glycol ether/sodium hydroxide (NaOH), ... |
41892521 | Formation and Release Enhancement of a Novel Small-Molecule Hydrogel Containing Sulindac and Meglumine. | Up to now, most hydrogel-related studies have been devoted to the preparation of drug-containing macromolecular gels via the introduction of polymer matrices, together with the clarification of their assembly mechanisms and biomedical applications. In contrast, studies concerning the design of small-molecule gel system... |
41853169 | Engineering Disordered Metallic Carbonaceous Materials: A Protocol for the Synthesis via Graphene Edge Hydrolysis. | This protocol is a comprehensive account of the intricate processes involved in the rational design, synthesis, and characterization of anisotropic metallic carbon materials. The materials were derived through the hydrolytic oxidation of graphene sheets, followed by self-assembly and mild annealing. The resulting produ... |
41852622 | Revisiting applications of itaconic acid-based polymers obtained by (poly)condensation chemistry. | For more than a decade, itaconic acid (methylene succinic acid) has been one of the most promising bio-based platform chemicals. The reliable availability in the market, combined with a competitive price, makes the implementation of this molecule as a building block very interesting, also from a commercial point of vie... |
41847148 | Nanotechnology-based targeted delivery strategies for the treatment of Alzheimer's disease. | Alzheimer's disease (AD), as a common neurodegenerative disorder, seriously affects human health. However, the treatment of AD has always faced significant challenges and has attracted extensive attention in medical research. In recent years, nanoparticle-based therapeutic strategies have been identified as a promising... |
41836448 | Advancing immunotherapy via multiple immune cells co-engagement. | Immunotherapy has demonstrated remarkable clinical success in a wide range of malignancies, owing to its high specificity and durable therapeutic effects. However, its efficacy is constrained by multiple factors arising from the complex and heterogeneous tumor microenvironment (TME). Strategies capable of simultaneousl... |
41836287 | Mechanical forces orchestrate the epigenetic landscape of oral mesenchymal stem/progenitor cell fate in dental and periodontal tissues. | The oral cavity serves as the primary source of oral mesenchymal stem/progenitor cell populations residing in the dental pulp, periodontal ligament, deciduous tooth pulp, and gingival connective tissue. Oral and periodontal tissues exist in a constantly loaded biomechanical environment, where forces from mastication, v... |
41836010 | Ketoprofen-loaded quatsomes as a smart repurposed antifungal therapy for vaginal infections: formulation, characterization, and microbiological evaluation. | <h4>Introduction</h4>Vulvovaginal candidiasis (VVC) is one of the most common fungal infections requiring more effective and patient-friendly therapies. This study introduces repurposed Ketoprofen (KPN) Quatsomes (QS) as a novel nano-platform for localized antifungal treatment.<h4>Methods</h4>KPN-QS were prepared using... |
41836020 | Antibody-enabled structural biology and AI-driven antibody design. | Membrane proteins govern essential cellular processes, including ion transport, signal transduction, and molecular recognition, and collectively represent more than half of all current therapeutic targets. Yet their structural characterization remains challenging due to intrinsic instability, amphipathic surfaces, and ... |
41835610 | Facile Synthesis, Characterization, Cytotoxicity, and Magnetic Properties of FA@Fe<sub>3</sub>O<sub>4</sub> Nanoparticles. | A magnetic composite FA@Fe<sub>3</sub>O<sub>4</sub> is formed by coupling magnetic iron oxide (Fe<sub>3</sub>O<sub>4</sub>) with folic acid (FA) through a facile hydrothermal synthesis process. The morphology, particle size, elemental composition, and magnetocaloric properties have been characterized by means of transm... |
41835604 | Modification of Whey Protein Isolate with Surfactants Based on Hofmeister Series and Interaction Parameter. | Developing thermoplastic materials from proteins requires structural reorganization and stabilization of specific intermolecular interactions. In this study, we modified whey protein isolate (WPI) with different surfactantstwo cationic (cetylpyridinium chloride, CPC, and benzalkonium chloride, BC) and one anionic (sod... |
41835583 | Recent Advances in Transition-Metal-Catalyzed Selective Synthesis of π‑Conjugated Silacycles: A Mini-Review. | Although the synthesis of silacycles is of significant importance, it remains far less explored than that of N-, O-, and S-heterocycles. The past few years have seen growing attention toward the synthesis of these silacycles, owing to their applications in light-emitting materials, thin-film transistors, electrolumines... |
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