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41835516 | Electrosprayed Magnetic Poly(butyl methacrylate-<i>co</i>-(2-dimethylaminoethyl) methacrylate-<i>co</i>-methyl methacrylate)/Iron Oxide Microparticles for Efficient Curcumin Delivery. | This study successfully optimized the electrospraying process of poly-(butyl methacrylate-<i>co</i>-(2-dimethylamino)-ethyl methacrylate-<i>co</i>-methyl methacrylate) (P-(BMA-<i>co</i>-DMAEMA-<i>co</i>-MMA)) copolymer solutions containing curcumin (CUR) and iron oxide (Fe<sub>3</sub>O<sub>4</sub>) for the production o... |
41835270 | Detection technologies and sensing systems for crop pest identification and infestation severity prediction: a review. | With the rapid development of precision agriculture technology, agricultural production is gradually shifting from traditional experience-based practices to data-driven decision-making. Pest species identification and scale prediction are crucial technologies in the field of pest detection. Compared with traditional pe... |
41835268 | Analysis of the TIL gene family in Brassicaceae species and functional study of <i>BrTIL1</i> in cold tolerance. | Temperature-induced lipocalins (TILs) are a class of thermoregulated lipid-transporting proteins crucial for plant stress responses. However, systematic research on the TIL gene family remains relatively limited. In the present study, we conducted a comparative analysis of the TIL gene family in five Brassicaceae speci... |
41835004 | Antibacterial hydrogels for skin infected wounds: frontier approaches as antibiotic alternatives therapy. | Skin wound infections are common and clinically challenging. Conventional antibiotic therapies are increasingly ineffective because of escalating bacterial resistance, highlighting the urgent need for alternative treatment strategies. Antibacterial hydrogels, multifunctional polymeric materials that integrate moisturiz... |
41834638 | Failure of early creatinine recovery predicts poor survival after emergency surgery for bowel perforation or infarction. | <h4>Background</h4>Early postoperative recovery of kidney function is critical in emergency bowel surgery. This study evaluated the prognostic value of preoperative creatinine elevation (PCE) and early creatinine recovery (ECR).<h4>Methods</h4>A total of 424 patients underwent emergency surgery for bowel perforation or... |
41829756 | Chemical Composition, Enantioselective Profile, and Preliminary Screening of Biological Activities of the Essential Oil from Aerial Parts from <i>Lasiocephalus ovatus</i> Schltdl. | Traditionally, <i>Lasiocephalus ovatus</i> Schltdl. (Asteraceae) has been used as an aromatic medicinal plant, particularly in the treatment of kidney-related ailments. However, scientific evidence validating its chemical composition and bioactivity remains limited. According to our literature search, there are no prev... |
41823815 | Microbiome-Metabolome Analyses Reveal Compound Risks from Multiple-Generation Cocoon Accumulation in Honeybee Combs. | The accumulation of cocoons within brood cells of old combs is a key factor causing a series of negative impacts on bee colonies. Previous studies did not sufficiently address this dynamic nature as the core microenvironment for preimaginal bee development. During this accumulation, the enrichment of potentially harmfu... |
41823820 | Structure-Based Screening of Deep-Sea Microbial Metabolites Against <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase. | Malaria is a major global health concern caused by <i>Plasmodium</i> parasites, among which <i>Plasmodium falciparum</i> is responsible for the most severe and fatal cases. The emergence of drug resistance to existing antimalarial therapies necessitates the discovery of novel molecular targets and chemically distinct i... |
41823763 | Efficient Encapsulation and Sustained Release of Linalyl Acetate Using Fractal Bimodal Mesoporous Silica. | Linalyl acetate is a key bioactive component of essential oils with notable calming and sedative effects; however, its high volatility severely limits stability and practical application. Herein, bimodal mesoporous silica (BMMs) was employed as an efficient carrier to encapsulate linalyl acetate using liquid- and gas-p... |
41823755 | Biofilm Control with Rare-Earth Oxides: A Mechanistic Framework for Next-Generation Antibiofilm Materials. | Biofilm-associated infections remain a major barrier to wound healing, implant integration, and chronic infection management. Rare-earth oxides (REOs) have emerged as promising antibiofilm materials, though their mechanisms, limitations, and translational potential are still being defined. Cerium oxide (CeO<sub>2</sub>... |
41810363 | Walnut glutelin antibacterial peptides target <i>Staphylococcus aureus</i> through metabolic pathway and novel antibacterial peptides identification. | To address challenges from biofilm-forming, antibiotic-resistant pathogens like <i>Staphylococcus aureus,</i> this study explored walnut glutelin antibacterial peptides (WGAP) as sustainable alternatives, integrating metabolomics, peptidomics, and computational biology to uncover their mechanisms and identify novel ant... |
41809385 | Polysaccharide-functionalized gold, silver, and iron oxide nanoparticles for siRNA delivery: The role of artificial intelligence in design and optimization. | Polysaccharide-functionalized metallic nanoparticles (MFNPs), including gold (Au), silver (Ag), and iron oxide (Fe<sub>3</sub>O<sub>4</sub>), have emerged as promising nanocarriers for small interfering RNA (siRNA) delivery in cancer nanomedicine. Functionalization with polysaccharides enhances their biocompatibility, ... |
41799960 | Degradation-tunable coating with sustained silver release for spinal implants to prevent postoperative infections. | Irreducible atlantoaxial dislocation is a challenging condition for spine surgeons and carries a particularly high risk of postoperative infection due to its trans-oral approach for peri-odontoid soft tissue release. Conventional antibacterial implant coatings are limited by rapid burst release, leading to short-term e... |
41799962 | Spatiotemporal activation of unfolded protein response by combined sonodynamic therapy and proteasome inhibition with bortezomib-conjugated TiN nanoparticles. | Activation of unfolded protein response (UPR) has recently been identified as a new target for cancer therapy. However, pharmacological agents activating UPR have not been approved in clinical practice. In this study, spatiotemporally controllable UPR activation was realized by the combination of ultrasound (US)-trigge... |
41798632 | Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail. | Non-ribosomal lipopeptide antibiotics derive much of their antibacterial performance from the structure of their lipid tail, yet genome mining remains largely peptide-centric and rarely prioritizes lipid donor formation as an entry point. Herein, we establish a lipid-donor-anchored discovery strategy using <i>pfa</i>-t... |
41783574 | Radiopharmaceutical: An Update and Comparison of Preclinical Investigation Result of Alpha and Beta Emitter Radioisotope. | Radiopharmaceuticals are radioactive compounds used for diagnostic imaging and therapeutic purposes. In diagnostic, gamma emitters are commonly utilized. Conversely, radioisotopes employed for therapy are beta and alpha emitters, which generally have contrasting Linear Energy Transfer (LET) and tissue penetration profi... |
41783546 | Nanozyme-Based Anti-Inflammatory Strategies in Cardiovascular Disease Management: Clinical Prospects and Challenges. | Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Research indicates that inflammatory responses and oxidative stress mediated by reactive oxygen species (ROS) are hallmark pathological mechanisms of CVD. Traditional anti-inflammatory drugs, though widely used, have limitations such a... |
41783547 | Dual-Action Theranostic Nanoparticles Delivering Toll-Like Receptor 2 Inhibitors and Chemotherapy Target Breast Cancer Cells and the Tumor Microenvironment. | <h4>Purpose</h4>Breast cancer remains the leading cause of cancer-related death in women, largely due to therapy resistance driven by both tumor-intrinsic and tumor microenvironment (TME)-mediated mechanisms. Toll-like receptor 2 (TLR2), which is overexpressed in breast tumors, promotes cancer progression and chemoresi... |
41783153 | Bioinformatic Analysis and Experimental Verification Reveal the Protective Role of Baicalein Against LPS-Induced Endothelial Cell Dysfunction. | <h4>Background</h4>Endothelial cells play a central role in the pathogenesis of sepsis. Currently, effective therapeutic options for sepsis remain limited. Baicalein (BAI) is a compound with multiple bioactivities. This study aims to investigate the protective effects of BAI against lipopolysaccharide (LPS)-induced end... |
41783014 | Tuning Covalent Organic Frameworks via Nucleophilic Aromatic Substitution. | A family of covalent organic frameworks (COFs) with tuned properties has been prepared through nucleophilic aromatic substitution (S<sub>N</sub>Ar) from a fluorinated imine-linked COF (COF-F). The method has proved useful for O-, S-, and N-based nucleophiles, including bifunctional molecules, leading to average degrees... |
41769040 | Cigarette butt waste as material for phase inverted cellulose acetate membranes synergistically incorporated with silver/copper oxide (CA-Ag/CuO) for reverse osmosis water treatment. | The improper disposal of cigarette butts presents a significant environmental challenge, yet their cellulose acetate (CA) content offers the potential for upcycling into functional materials. In the study, the potential of using CA waste obtained from cigarette butts for fabricating CA phase-inverted membranes is demon... |
41769038 | A review of lead leakage monitoring in perovskite solar cells: emerging detection technologies, just transition to clean energy and perspectives. | Lead-based perovskite solar cells (LPSCs) offer promise for low-cost, highly efficient alternatives to current solar energy technologies, with the potential for scale-up production and high-throughput coating. However, lead leakage, which is considered a health hazard, instability due to moisture intrusion into the per... |
41768784 | A Glimpse in the Metal Ion Selectivity Rules: Zn(II), Cd(II) and Co(II) Interplay With Different Protein Coordination Spheres in Determining Variable Thermal Stability and Folding Scenarios. | Models designed to study protein/metal ion interaction are helpful to provide insights into the rules of metal ion selectivity. In this context, the prokaryotic zinc finger family Ros/MucR offers an example of several naturally occurring homologues binding a structural zinc ion with coordination spheres characterized b... |
41767811 | Pnictogen-bonding-crosslinked polymer networks: constructing self-healing materials. | Herein, we introduce pnictogen bonding interaction into polymer networks for the design and modulation of dynamic macromolecular materials. Several types of polymeric pnictogen-bonding networks with graded interaction strengths were constructed to explore the structure-property relationship. Comprehensive investigation... |
41767233 | Recent developments in the organocatalytic asymmetric cycloaddition/annulation reactions involving indolylmethanols. | Enantioenriched indole frameworks constitute the structural core of a wide array of biologically active natural products and therapeutic agents; as such, their synthesis has emerged as a central and enduring objective in organic synthesis. In this regard, suitably substituted indolylmethanols have emerged as versatile ... |
41767220 | Comprehensively investigating pharmacokinetics and metabolic fate of andrographolide in rats by liquid chromatography/mass spectrometry-based approach. | Andrographolide, a natural labdane diterpenoid lactone isolated from <i>Andrographis paniculata</i>, possesses diverse pharmacological properties such as anti-tumor, anti-inflammatory, antiviral, and immunomodulatory activities, rendering it a promising candidate for therapeutic development. In this study, pharmacokine... |
41767225 | Scaffold-based biomaterials in ovarian tissue engineering. | The rapid evolution of reproductive tissue engineering has positioned biomaterials as key enabling tools for the development of artificial ovary technologies aimed at fertility preservation and ovarian function restoration. Conventional assisted reproductive technologies mainly target late-stage folliculogenesis and re... |
41767160 | The impact of dynamic bonding associations on the rheology of amine containing polyolefins. | Polyolefins are utilized in a wide array of applications due to their desirable and predictable properties. The incorporation of polar functional groups into the nonpolar backbone imparts an opportunity to further tune the properties and broaden the application space. Among the library of H-bonding chemistries that hav... |
41766939 | Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring. | Atrazine (ATZ) is an endocrine-disrupting chemical, and ATZ exposure during perinatal development is linked to reproductive dysfunction and behavioral abnormalities in adulthood. Gestational ATZ exposure can adversely affect birth weight, fetal growth, and onset of puberty. To investigate ovarian effects of ATZ exposur... |
41765305 | β-Cyclodextrin-nickel biomacromolecular host system for sustainable ligand-free aqueous CC and CN cross-couplings of aryl chlorides: Toward donor-π-acceptor distyrylbenzene chromophores. | A sustainable, ligand-free aqueous method for activating aryl chlorides has been established using a β-cyclodextrin-nickel biomacromolecular host catalyst (Ni-MNPCD) with zinc powder as an in-situ reductant. The amphiphilic β-cyclodextrin (β-CD) structure creates a confined hydrophilic-hydrophobic microenvironment that... |
41763200 | High-resolution in situ structures of hantavirus glycoprotein tetramers. | New World hantaviruses cause severe infections in humans. Previous structural studies have advanced our understanding of hantavirus glycoprotein architecture; however, the lack of high-resolution structures of the glycoprotein tetramer and its lattice organization has limited mechanistic insights into viral assembly an... |
41761652 | Oxygen Evolution Reaction Catalysts for Acidic-Media CO<sub>2</sub> Electrolyzers. | Acidic-media electrochemical CO<sub>2</sub> reduction (CO<sub>2</sub>R) offers high single-pass CO<sub>2</sub> conversion (SPCE) and low purification cost, yet relies on scarce noble metals (e.g., iridium and ruthenium) for the anodic oxygen evolution reaction (OER). The limited abundance of these catalysts constrains ... |
41761639 | Redox Cascade-Driven Structural Degradation Under Reverse Bias in All-Perovskite Tandem Solar Cells. | Reverse bias, originating from current mismatch or shading, has emerged as a hidden yet fatal instability in all-perovskite tandem solar cells. Here we reveal that sustained reverse bias triggers a redox-coupled lattice collapse within the narrow-bandgap subcells. Under electrical stress, hole injection oxidizes iodide... |
41761333 | Cell-free DNA in precision medicine: overcoming biological barriers through integrated nanoparticle platforms for simultaneous diagnosis and therapy. | Cell-free DNA (cfDNA), released into the bloodstream through cell death and cellular stress, has emerged as a highly promising noninvasive biomarker with broad diagnostic and therapeutic potential. However, clinical translation of cfDNA remains limited by its intrinsic properties, including extensive fragmentation, ver... |
41761325 | A DNA nanoflowers-based microneedle patch for transdermal gene and photodynamic therapy against melanoma. | DNA nanostructures show great potential as drug carriers in biomedicine, however, biological barriers and stability issues limit their applications, particularly for aggressive melanoma shielded by the skin barrier. This study presents a hyaluronic acid-based microneedle patch integrated with DNA nanoflowers to effecti... |
41761284 | PROTAC-based protein degradation: a window of opportunity for melanoma therapy. | The key small molecule-based modalities for inducing targeted protein degradation have seen explosive growth over the past decade. They include heterobifunctional degraders such as PROteolysis TArgeting Chimeras (PROTACs): molecules working as protein degraders by inducing proximity between a protein of interest, mostl... |
41761261 | Synthesis, characterization, and photocatalytic degradation of toxic dyes from wastewater using AgI@Sn-BDC-NH<sub>2</sub> heterojunction nanocomposites. | Metal-organic frameworks (MOFs) have attracted significant research interest as promising innovative platforms for designing heterojunction photocatalysts. Herein, we report the rational design and preparation of an AgI@Sn-BDC-NH<sub>2</sub> heterojunction composite via a simple and facile in-situ route to degrade orga... |
41761201 | Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway. | Hypercholesterolemia is a major risk factor for the development of atherosclerotic cardiovascular disease. The flavonoid fisetin shows potential cholesterol-regulating effects. Nevertheless, poor solubility and low bioavailability limit its clinical application. This study investigates fisetin's effects on hypercholest... |
41761180 | Research advances and future perspectives of nanomaterials for depression therapy: a scientometric review. | <h4>Background</h4>Depressive disorder is one of the most common mental health conditions with significant repercussions on both the physical and psychological health of affected individuals. In recent years, an increasing number of studies have been undertaken to evaluate nanomaterials for the diagnosis and treatment ... |
41760732 | Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery. | Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disorder that complicates the identification of effective therapeutic targets. The potential of stem cells and neurotrophins as promising candidates has become increasingly evident, owing to their neuroprotective and anti-inflammatory properties.... |
41760688 | Visualizing molecular diffusion direction and processes in the solid state via dichromatic fluorescent cocrystalization transformation. | Solid-state molecular motion (SSMM) plays a critical role in enriching material properties and functions, yet visualizing its detailed dynamics including direction, progression, and velocity to thoroughly elucidate its mechanism remains a great challenge. Herein, an intermolecular charge transfer (ICT)-mediated fluores... |
41760673 | Activity drives self-assembly of passive soft inclusions in active nematics. | Active nematics are out-of-equilibrium systems in which energy injection at the microscale drives emergent collective behaviors, from spontaneous flows to active turbulence. While the dynamics of these systems have been extensively studied, their potential for controlling the organization of embedded soft particles rem... |
41760652 | Structure and energy transfer of a far-red-absorbing euglenophyte PSI-LhcE-LhcbM supercomplex. | Euglenophyta originated from a secondary endosymbiosis between a phagotrophic euglenid and a green alga. Euglenophytes acquired photosynthesis-related genes from diverse algal lineages, representing a remarkable example of plastid evolution in the green lineage. Here, we solve the structure of the PSI-LhcE-LhcbM superc... |
41760646 | Synthesis of 3-desoxycollinoketone B and its ability to reduce Alzheimer-associated misfolded proteins. | Collinolactone, featuring a 7/10/6 tricyclic core, has been proposed to be biosynthesized via a transannular [6 + 4] cycloaddition reaction. Besides its intriguing architecture, collinolactone holds pharmaceutical promises due to its ability to disrupt amyloid-β (Aβ) and tau aggregation, which are specifically found as... |
41760641 | Ultramicroporous covalent organic framework membranes with fortified hydrogen-bond networks for high-performance desalination. | The increasing global reliance on alternative water sources underscores the critical need for enhanced desalination efficacy. Covalent organic frameworks (COFs), with their ordered porosity and tunable architectures, hold immense potential for next-generation desalination membranes. However, current COF membranes often... |
41760625 | Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas. | Secondary resistance to the amino-acid-depleting agent L-asparaginase (ASNase) remains poorly understood. Using ASNase-sensitive B-cell lymphoma (BCL) models, we investigate tumor relapse during treatment. Through in vitro and in vivo metabolic profiling, here we show that ASNase triggers a metabolic reprogramming char... |
41760622 | Crystallization-driven template autocatalysis induces mirror symmetry breaking and amplification. | A plausible hypothesis for the origin of biological homochirality invokes chiral symmetry breaking, transfer, and amplification driven by autocatalysis. Here we experimentally demonstrate that crystallization-driven template autocatalysis (CDTA) induces mirror symmetry breaking and amplification in helices. CDTA enable... |
41760630 | Electron confinement-enhanced green InP-based quantum dots for active-matrix LEDs displays. | The facet-selective growth of shells on green InP-based quantum dots result in their inferior electron confinement capabilities, posing a challenge for the realization of completely cadmium-free quantum dot light-emitting diode displays. Here, we develop a surface energy homogenization strategy based on ligand adsorpti... |
41760610 | Femtosecond concerted rotation of molecules on a 2D material interface. | Interfaces between molecules and 2D materials exhibit energy-driven functionalities, wherein charge transfer directs molecular motion. Unlike equilibrium systems, where molecular assemblies settle into static configurations, continuous energy input can drive transient, collective molecular rearrangements. Here, we reve... |
41760608 | Single-cell structural biology with intracellular electron crystallography. | Intracellular crystallization is an emerging approach in structural biology that bypasses the need for protein purification. In 2024, the InCellCryst pipeline was introduced for structural studies of intracellular crystals by serial X-ray crystallography. Serial crystallography requires the exposure of tens of thousand... |
41760606 | In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems. | Skin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process. In vitro models are powerful tools for exploring skin aging and overcoming ... |
41760603 | ISGylation prevents autophagic degradation of STING and promotes antitumor immunity in lung cancer. | The STING pathway plays a central role in immune activation; however, STING protein levels decline during the progression of various cancers, including lung cancer, thereby limiting the efficacy of immunotherapies. Our study uncovers a previously unrecognized mechanism whereby ISGylation stabilizes STING by preventing ... |
41760505 | Leveraging conformational ensembles in allosteric drug discovery. | Proteins involved in signaling networks, such as Ras, mammalian target of rapamycin (mTOR), and epidermal growth factor receptor (EGFR), exist as dynamic conformational ensembles in biomolecular condensates. These ensembles play a crucial role in allosteric drug discovery and action. Traditional approaches in drug disc... |
41760081 | Adsorption-Driven Symmetry Lowering in Single Molecules Revealed by Ångstrom-Scale Tip-Enhanced Raman Imaging. | The vibrational landscape of adsorbed molecules is central to understanding surface interactions at the atomic scale, influencing phenomena from catalysis to molecular electronics. Recent advances in atomic-scale tip-enhanced Raman spectroscopy (TERS) have enabled vibrational mapping of single molecules with subnanomet... |
41759551 | Dissecting the Binding Interactions of the Chromatin Remodeler SMARCA4 with G-Quadruplex DNA. | DNA G-quadruplexes (G4s) are key structural features in chromatin that are important to genome function. G4s have an apparent capacity to recruit a wide variety of proteins, including chromatin remodelers, yet the molecular basis and biophysical principles governing these interactions remain poorly understood. Here, we... |
41759210 | Ligand Versatility and Resistance Mechanism of Monotherapy-Grade HIV-1 Protease Inhibitor GRL-142 Binding the Multidrug Resistant Variant p51: Insights from 1 μs MD Simulations. | The emergence of HIV-1 highly resistant strains and the prevalence of HIV-associated neurocognitive disorders (HAND), are two of the biggest challenges posed to combination antiretroviral therapy (cART), despite promising advances in treatment. To address these issues, the protease inhibitor GRL-142 (G), an extremely p... |
41758950 | Rapid self-assembly of robust ultrathin ionogel films for high-performance bioelectronics. | Ionogels, polymer networks infiltrated with ionic liquids (ILs), are promising for flexible electronics but face trade-offs among mechanical robustness, ultrathin form factors, and scalable fabrication. We present an IL-induced self-assembly strategy enabling the rapid formation of ultrathin polyvinyl alcohol (PVA) ion... |
41758905 | Structural Colors of Cyclic Diblock Copolymers Enabled by Topology-Driven Structural Ordering and Tuned by Blending with Constituent Cyclic Polymers. | Controlling structural colors of high-molecular-weight (HMW) block copolymers is challenging due to their pronounced chain entanglements, often limiting accessible polymeric architectures required for self-assembly into photonic crystals. Here, we demonstrate tunable structural colors in photonic films induced by the s... |
41758882 | Disposable non-enzymatic impedimetric biosensor using Mn-doped ZnS-chitosan nanocomposite for tetracycline detection. | Monitoring antibiotic residues in aquaculture water is critical for food safety, environmental protection, and antimicrobial stewardship. Here, we present a proof-of-concept disposable, non-enzymatic impedimetric biosensor for the rapid and selective detection of tetracycline. The sensor employs interdigitated electrod... |
41758782 | Transparent Photothermal Slippery Surface Based on Monolayer Self-Assembled MXene Film for Anti-Fogging and De-Icing. | Transparent surfaces with autonomous anti-fogging and de-icing capabilities are critical for smart windows, eyewear, and optical sensors. Existing solutions relying on wettability engineering or bulk photothermal materials suffer from poor transparency, contamination vulnerability, or energy inefficiency. Here, we repo... |
41758407 | Dynamic Covalent Boronate Chemistry for <i>In Situ</i> Formation, Interfacial Stabilization, and Cytomimetic Optimization of Coacervates. | Bioinspired synthetic cells are rapidly transforming the way we interrogate the principles of cellular life and the development of bioengineering and medical applications. However, despite significant progress in modeling cell-like behavior, material engineering remains a time-consuming and often behind-the-scenes ende... |
41758121 | Interplay between SpaO variants shapes the architecture of the <i>Salmonella</i> type III secretion sorting platform. | <i>Salmonella enterica</i> utilizes a virulence-associated type III secretion system (T3SS) to inject bacterial effectors directly into host cells. Central to this machinery is the sorting platform (SP), a cytosolic assembly whose core scaffolding protein, SpaO, is produced in two isoforms: a full-length (SpaO<sup>L</s... |
41758069 | Scope of Microbial Transglutaminase for Site-Specific and Oriented Immobilization of Native Antibodies from Various Host Species. | Modification of antibodies to chemically couple labels or immobilization reagents is essential for developing biosensors. Typically, conjugation occurs through chemical methods that leverage reactive amines and thiols on native antibodies; however, this nonspecific approach can interfere with antibody function. Microbi... |
41758015 | Synthesis of a Highly Fluorescent Quinoxalino[2,3-<i>b</i>]quinoxaline Polycyclic Derivative via Intramolecular Michael Addition to a Squaramide Ring. | In the presence of TBAOH, bis-indolylsquaramide (<b>1</b>) converts into the highly emissive, novel bis(3H-pyrrolo[1,2,3-de]quinoxaline) exa-cyclic derivative <b>2</b>. This compound was fully characterized in solution and the solid state, with emission properties supported by DFT calculations. Derivative <b>2</b> exhi... |
41757946 | A mutation-aware proteomics approach for designing a multi-epitope vaccine against multidrug-resistant <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>. | The increasing prevalence of multidrug-resistant <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in healthcare settings presents a critical challenge to global public health, necessitating the development of effective therapeutic strategies. Here, we report the rationale design of a mutation-aware mult... |
41757706 | Dokdothiocin, an Anti-Neuroinflammatory Thiopeptide from <i>Streptomyces</i> sp. 20A130. | Dokdothiocin, a ribosomally synthesized and post-translationally modified peptide (RiPP) belonging to the thiopeptide family, was isolated from <i>Streptomyces</i> sp. 20A130. Its structure was elucidated by extensive NMR analyses, high-resolution mass spectrometry, and chemical derivatization, revealing a 29-membered ... |
41757658 | Machine Learning-Informed Nano Co-Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue. | Nanoparticle-based drug delivery faces persistent challenges, including complex fabrication processes and limited lesional accumulation. Here we introduce SP-13786 (SP), a precise small-molecule inhibitor of fibroblast activation protein (FAP), as a universal and effective excipient enabling facile co-precipitation int... |
41757647 | Chiral Supramolecular Hydrogen Bonding Networks for Enantio-Selective Catalysis Against Neuroinflammation. | Non-covalent interactions are critical for regulating protein stability, reshaping catalytic active sites, and facilitating enzymatic reactions. Introducing these interactions into reticular materials offers a new approach to constructing artificial enzymes and more closely mimicking the catalytic microenvironment. Her... |
41757571 | Flower-Shaped Supramolecular Polymer Enabling Biofilm Eradication, Improved Foliar Affinity, and Bacterial Disease Management. | The management of bacterial plant diseases is impeded by biofilm fortifications and the poor foliar affinity of conventional antimicrobials. Supramolecular assemblies have recently emerged as promising biofilm-eradicating agents with enhanced surface adhesion. Yet, supramolecular polymers, although endowed with compara... |
41757568 | Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease. | Chagas disease is classified as a neglected tropical disease (NTD) and is predominantly endemic in South America. Despite advances in modern medicine, more than 10 million people worldwide are currently infected, and approximately 12 000 deaths are reported annually. The World Health Organization (WHO) aims to eliminat... |
41757518 | Heterogeneity-Guided Interlayer Tuning in Vermiculite-MOF Membranes for Efficient Li<sup>+</sup>/Mg<sup>2+</sup> Separation. | Precise separation of Li<sup>+</sup>/Mg<sup>2+</sup> with similar ionic size remains a critical challenge for two-dimensional (2D) membranes, largely due to the inherently tortuous and poorly regulated transport channels in the 2D interlayer. Herein, we propose a heterogeneity-guided interlayer engineering strategy to ... |
41755744 | Selectivity Modulation of Small Cationic Membrane-Active Cyclic Peptides with Broad-Spectrum Activity against Bacteria and Fungi. | To investigate how ring size and backbone flexibility influence antimicrobial potency and cytotoxicity, we synthesized a series of macrocyclic peptides of lead peptide <b>p1</b> (c[Arg-Arg-arg-arg-dip-Trp-dip]) by incorporating Gly, 2-aminoethoxyacetic acid (EAA), or 2,4-diaminobutyric acid (Dab). Two optimized peptide... |
41755710 | Strong Exciton Confinement Enabling Near-Unity Photoluminescence Quantum Efficiency in Hybrid Bimetallic Halides. | Development of efficient and structurally stable zero-dimensional (0D) hybrid antimony halide materials still encounters huge challenges due to the limited and time-consuming trial-and-error design principle. Here, a host-guest chemistry strategy is employed at the A-site to design a series of hybrid antimony-based bim... |
41614215 | Uncovering mitotic ultrastructure in the native hair follicle using volume electron microscopy. | The hair follicle undergoes repeated cycles, with anagen representing the active growth phase. During anagen, transit amplifying cells within the germinative matrix at the follicle bulb drive rapid proliferation for hair growth. This region exhibits some of the highest mitotic rates observed in any tissue, offering a r... |
41386794 | Are Drains After Trauma Splenectomy Associated with Organ Space Surgical Site Infections? | <b><i>Introduction:</i></b> Left upper quadrant (LUQ) drain use after trauma splenectomy varies, with minimal existing data to guide practice. We aimed to investigate the association of LUQ drains with organ space surgical site infection (OS-SSI) after splenectomy. We hypothesized that LUQ drains after trauma splenecto... |
41988318 | Assessment of susceptibility to mTOR rs2295080 gene polymorphism in Guangxi Zhuang lung cancer population. | <h4>Background</h4>Lung cancer is a leading cause of cancer-related deaths globally. While single-nucleotide polymorphisms (SNPs) are established genetic modulators of cancer susceptibility, the specific functions of SNPs in the mammalian target of rapamycin (mTOR) pathway in lung cancer pathogenesis remain largely unc... |
41969485 | Co-assembled structures of Fe<sub>3</sub>O<sub>4</sub> nanoparticles for therapy of cervical cancer by inducing apoptosis and autophagy. | <h4>Background</h4>Cervical cancer is one of the most common cancers among women globally, and its treatments remain limited, urgently needing new strategies. In recent years, the use of enzyme-like Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) has exhibited promising antitumor potential due to their unique physicoch... |
41943842 | Dietary targeting of CNBP to rein in the EREG-EGFR cascade and restore homeostasis in colitis-associated colorectal cancer. | Emerging evidence has linked high dietary fructose intake with adverse health outcomes, yet its role in colitis-associated colorectal cancer (CAC) remains underexplored. Here, we demonstrate that high fructose consumption aggravates intestinal inflammation and significantly promotes tumorigenesis in an AOM/DSS-induced ... |
41901217 | Ambient-Stable mRNA Medicines: Emerging Paradigms in Dry and Solid-State Formulation. | The medical field now uses mRNA therapeutics to deliver fast programmable treatment options through versatile vaccination platforms. The worldwide adoption of mRNA therapeutics faces a major obstacle because these molecules require extreme cold storage and transportation systems. mRNA stability establishes a fundamenta... |
41901211 | Neoantigen-Encoded Oncolytic Viruses as Personalized Cancer Vaccines. | Neoantigen vaccines have revitalized cancer vaccination by targeting tumor-specific mutant epitopes largely absent from central tolerance. Yet, clinical benefits remain inconsistent, in part because conventional vaccine platforms often do not reliably deliver antigens within an inflammatory tumor context, struggle to o... |
41901214 | Self-Assembled Rg3/Naringenin Nanoparticles for Targeted Brain Delivery: A Promising Therapeutic Approach for Early Alzheimer's Disease. | <b>Background/Objectives</b>: Alzheimer's disease (AD) has an irreversible disease course, making early intervention a key measure to delay disease progression. However, existing therapies are limited by weak brain-targeted delivery efficiency due to the blood-brain barrier (BBB) and low bioavailability of drugs, makin... |
41899398 | Comparative Transcriptomic Analysis Reveals Key Pathways and Genes Involved in Late-Acting Self-Incompatibility in <i>Akebia trifoliata</i>. | Self-incompatibility (SI) is a key reproductive mechanism in angiosperms that prevents self-fertilization and promotes genetic diversity while limiting breeding efficiency. <i>Akebia trifoliata</i> is a recently domesticated economic crop native to East Asia with medicinal, edible, and oil-producing value. However, its... |
41898907 | Recent Advances in Sustainable Management of <i>Cylas formicarius</i>. | <i>Cylas formicarius</i> is a significant quarantine pest worldwide, causing year-round outbreaks in tropical and subtropical regions. This pest is characterized by a highly cryptic nature, a high reproduction rate, and broad environmental adaptability, which makes it difficult to control. Frequent use of pesticides is... |
41898169 | Tau Protein Aggregation Inhibitors-Therapeutic Strategy for Concurrent Tau and Amyloid Aggregation Inhibition. | Tau protein, a microtubule-associated protein widely distributed in the central nervous system, aggregates abnormally and forms neurofibrillary tangles in neurodegenerative diseases. Particularly in Alzheimer's disease, pathological tau protein aggregates disrupt the structure and function of neurons, triggering other ... |
41898168 | Nanotechnology-Based Strategies for Hair Regeneration: Mechanistic Insights and Translational Perspectives for Androgenetic Alopecia. | Androgenetic alopecia (AGA) is a highly prevalent and progressive disorder characterized by follicular miniaturization and dysregulation of the hair follicle microenvironment. Although minoxidil (MXD) and finasteride remain first-line therapies, their long-term efficacy is limited by poor follicular bioavailability, sy... |
41897289 | Ginsenosides in Modern Pharmaceutics: Mechanisms, Applications, Challenges, and Perspectives. | Ginsenosides are the primary bioactive constituents of <i>Panax ginseng</i>, exhibiting multiple pharmacological activities, including neuroprotection, antitumor effects, anti-aging properties, and metabolic regulation. In this review, the molecular mechanisms of ginsenosides in treating neurodegenerative diseases, can... |
41893641 | Evaluating the Antioxidant Potential of Coumestrol in the Treatment of Tripterygium Glycoside-Induced Oligospermia in Rats and Its Potential Mechanisms. | Tripterygium glycoside (TG) is known to disrupt the oxidative balance in bio-systems, inducing oxidative stress-mediated toxic effects on testicular tissue. This study aimed to explore the therapeutic potential of coumestrol (COU) against these adverse effects. Sixty-four male Sprague-Dawley rats were randomized into c... |
41893640 | Computational Identification of Natural Inhibitors Targeting Fiber Proteins of FAdV-1 and FAdV-4 Through Integrated Virtual Screening and Molecular Dynamics Simulations. | Fowl adenoviruses (FAdVs) represent a major threat to poultry health, with serotypes FAdV-1 and FAdV-4 causing adenoviral gizzard erosion (AGE) and hepatitis-hydropericardium syndrome (HHS), respectively. A wide variety of afflicted birds, including chicken, pigeon, and psittacine species, have been reported to carry a... |
41893579 | Fitness Adaptations to a Combined Strength and Aerobic Training Program During the Transition Period in Young Soccer Players. | The annual soccer training cycle consists of preparatory, competitive, and transition periods. The transition phase is usually characterized by a decrease in training volume, which may lead to detraining and declines in physical fitness. The aim of this study was to examine the effects of a structured transitional trai... |
41893270 | Selective Capture and Continuous Recovery of Sulfur-Containing Molecules from Flowing Wastewater Using a Capillary Ag<sub>2</sub>Mo<sub>3</sub>O<sub>10</sub>·1.8H<sub>2</sub>O/Carbon Fiber Membrane System. | This work presents a novel, membrane-inspired hybrid framework composed of Ag<sub>2</sub>Mo<sub>3</sub>O<sub>10</sub>·1.8H<sub>2</sub>O nanowires grown in situ on carbon fiber cloth (CFC) for the continuous and selective recovery of high-value sulfur-containing molecules from organic wastewater. The framework forms an ... |
41892741 | Fluorescence-Guided Chitosan and Eugenol-Based Carbon Dots for Comprehensive Infection Control and In Vitro Wound-Healing Applications in Dentistry. | <b>Background/Objectives:</b> The transformation of multifunctioning nanomaterials, incorporating antimicrobial activity and regenerative incompatibility, is becoming even more significant in the modern dental therapeutic context. <i>Streptococcus mutans</i> (<i>S. mutans</i>) is primarily linked to dental caries and p... |
41892030 | Surface Plasmon Resonance as a Tool in Antiviral Drug Discovery Research. | Viruses are an indispensable part of the environment we live in. The occurrence of seasonal and pandemic infections underscores the urgent need to develop new antiviral drugs or repurpose existing ones. Among the methods used in research on new antiviral molecules, surface plasmon resonance (SPR) has a well-established... |
41892029 | Recent Progress on Carbon-Dots-Based Probes for Microbial Labeling and Versatile Analysis Applications. | Microbial imbalance and the spread of pathogenic microorganisms pose severe threats to human health and ecological security. Traditional microbial detection methods suffer from several drawbacks such as long detection time, low sensitivity, and insufficient specificity. As an emerging fluorescent probe, carbon dots (CD... |
41884412 | Catalytic Methods for the Transfer of Nonstabilized Carbenes. | Transition-metal catalysis has fundamentally transformed the way we construct molecules because of the ability of d-block elements to couple two structurally complex molecular fragments. Suzuki and Negishi-type cross-coupling methods are prevalent in catalysis; however, reactions involving metal-carbene alkene coupling... |
41858897 | Dual-mode <i>in situ</i> monitoring of CO<sub>2</sub> conversion via pH indicator and UV-vis spectroscopy. | The integration of the KHCO<sub>3</sub>-fed bipolar membrane (BPM) electrolyzer with potassium hydroxide (KOH)-based carbon dioxide (CO<sub>2</sub>) capture enables directly <i>in situ</i> conversion of captured CO<sub>2</sub> into valuable carbonaceous products, eliminating costly CO<sub>2</sub> recovery and compressi... |
41858764 | Organelle homeostasis disruption: A driving force in the progression of cardiomyopathy (Review). | Cardiomyopathy is a complex heart disease with structural and functional defects of the myocardium, often leading to poor clinical outcomes. While traditional research has focused on myofibrillar pathology and ion channel dysfunction, emerging evidence indicates that organelle homeostasis serves a central role in the p... |
41853684 | Computational hybrid framework integrating clinical-mutation profiling and physics-based simulations to predict structural tolerance of Bruton tyrosine kinase (BTK) and sustained ARQ 531 binding. | Bruton tyrosine kinase (BTK) is a non-receptor tyrosine kinase crucial for relaying signals from the B cell antigen receptor (BCR) in cancerous B lymphocytes. It has been reported that mutations in this protein cause resistance to various covalent and non-covalent drugs. Therefore, we employed a computational genomic m... |
41853604 | Stearic acid modified nanofiber membranes for flavor improvement of oyster enzymatic hydrolysates: structural characterization and selective adsorption deodorization. | The strong fishy odor of oyster enzymatic hydrolysates (OEHs) severely limits their consumer acceptability. In this study, electrospun nanofiber membranes were prepared using octenylsuccinylated starch and pullulan as raw materials, followed by hydrophobic modification via stearic acid (STA) soaking. With increasing ST... |
41835522 | Toward a Mechanistic Framework for Intestinal Drug Permeability: Integrating <i>In Silico</i> Modeling with Biorelevant Assays. | Predicting oral bioavailability remains a central challenge in pharmaceutical sciences, primarily limited by the phenomenological nature of traditional predictive models that provide correlations without mechanistic insight. While molecular dynamics (MD) simulations provide detailed atomistic insights into drug-membran... |
41835065 | Metabolic dysfunction and mitochondrial failure in Alzheimer's disease: integrating pathophysiology, clinical evidence and emerging interventions. | Alzheimer's disease (AD) is a gradual and irreversible decline in the brain's ability to function which is not only signified by amyloid-beta plaques and neurofibrillary tangles but also by and metabolic and mitochondrial changes that have a negative impact on the classical neuropathological hallmarks. It is becoming i... |
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