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41834999 | Point-of-care molecular diagnostics and drug-resistance mechanisms in neglected infectious diseases: current advances and future therapeutic opportunities. | The rising burden of neglected infectious diseases and the accelerating spread of antimicrobial resistance (AMR) demand rapid, accurate, and decentralized diagnostic solutions. Point-of-care (POC) molecular diagnostics enable early diagnosis and resistance profiling during the clinical encounter, without reliance on ce... |
41829729 | Primary Stress Factors and Adaptive Mechanisms of Microalgae in Space Environments and Their Applications in Space Life Support Systems. | Cyanobacteria and eukaryotic microalgae (collectively referred to here as 'microalgae') represent early-evolving oxygenic phototrophs and are widely considered ideal candidates for bioregenerative life support systems (BLSS) due to their high metabolic efficiency and ecological robustness. Photosynthetic systems center... |
41828939 | Investigation of a Rare <i>CSN1S1</i><sup>01</sup> Allele in Goats Using Allele-Specific PCR and Mathematical Expectation Analysis. | The <i>casein alpha s1</i> (<i>CSN1S1</i>) gene plays an important role in milk protein synthesis and has been associated with milk quality and calcium-related physiological processes in mammals. To date, 19 <i>CSN1S1</i> variants have been reported. Among them, the <i>CSN1S1</i><sup>01</sup> allele has been described ... |
41828937 | Effects of Dietary Peanut Skin Proanthocyanidin Supplementation on Antioxidant Capacity and Intestinal Health of Juvenile American Eels (<i>Anguilla rostrata</i>). | This study was performed to explore the influences of dietary peanut skin proanthocyanidins (PSPcs) on the antioxidant capability and intestinal health of juvenile American eels (<i>Anguilla rostrata</i>). The American eels (10.50 ± 0.03 g) were randomly allocated to five groups. Five experimental diets were formulated... |
41828778 | Electrocatalytic Hydrogen Evolution Using Cyano-Substituted Triaryl Corrole Antimony(III) Complexes. | Developing molecular electrocatalysts with controllable and predictable properties remains a central challenge in hydrogen evolution reaction (HER) catalysis. Herein, four Sb(III) corrole complexes (<b>1</b>-<b>4</b>) bearing zero to three <i>p</i>-cyano-substituted <i>meso</i>-phenyl groups (-CN Ph) were synthesized t... |
41828775 | Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Axially Chiral Compounds. | Axially chiral compounds, indispensable in asymmetric catalysis, drug discovery, and materials science, have witnessed transformative advancements in synthesis through organocatalytic kinetic resolution (OKR) over the past decade. This review systematically dissects the latest achievements (2010-2025) in OKR, focusing ... |
41828768 | Stabilization of Allyl Isothiocyanate by β-Cyclodextrin: Thermal Robustness and Potent Antimicrobial Activity. | Allyl isothiocyanate (AITC) is a potent natural antimicrobial agent; however, its practical application is severely hindered by its extreme volatility and pungent, irritating odor. In this study, AITC inclusion complexes (AITC@β-CD) were successfully fabricated via a co-precipitation strategy using β-cyclodextrin (β-CD... |
41828407 | Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation. | Neuroinflammation is a critical pathological process implicated in several neurological disorders. It arises from complex interactions among immune cells and the excessive release of pro-inflammatory mediators, ultimately leading to neuronal damage. Ergothioneine (EGT), a naturally occurring antioxidant, has attracted ... |
41823752 | Metal Manipulated Fluorescence: Mechanisms, Materials, and Plasmonic Strategies for Enhanced Emission. | Fluorescence remains a foundational optical phenomenon underpinning applications in sensing, imaging, diagnostics, and catalysis. Among the strategies developed to modulate fluorescence, coupling fluorophores with plasmonic metals has emerged as a powerful route for both enhancement and quenching. The collective excita... |
41816621 | Photochemical reduction of aryl chlorides, bromides, and iodides <i>via</i> ternary EDA complexes with guanidine bases. | Photoredox catalysis has traditionally required sophisticated catalyst design, multi-photon systems, or photoelectrochemical strategies to reach the reducing potentials necessary for aryl chloride activation. In a surprising departure from these paradigms, we find that a simple, bench-stable guanidine base, TBD, functi... |
41809589 | Unraveling bulk degradation mechanisms of wide-bandgap perovskite absorbers for tandem applications. | Wide-bandgap (WBG) perovskite absorbers play a pivotal role in enabling high-efficiency tandem solar cells; yet, their long-term operational stability remains a significant hurdle to commercialization. Although interface engineering has led to promising progress, these improvements have not yet translated into the leve... |
41809551 | Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine. | Precision medicine calls for molecular tools that enable high-resolution imaging at depth, accurate lesion localisation and controllable therapy. Small-molecule dyes are widely used in biomedical imaging and treatment, yet their limited photostability, susceptibility to quenching in physiological environments and rapid... |
41809378 | Biomimetic sequentially gated nanotuners based on amorphous metal-organic frameworks for reprogramming the metabolism-ferroptosis-immunity crosstalk in gliomas. | Glioma's metabolic reprogramming fortifies antioxidant defenses and fosters an immunosuppressive microenvironment, thus resulting in robust resistance to ferroptosis-immunotherapy. In this study, a biomimetic sequentially gated amorphous MOF-based nanotuner (ZB@HM) was constructed, which could cascade depletion of meta... |
41799951 | Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application. | Mesenchymal stromal cells (MSCs) possess potent immunomodulatory, pro-angiogenic, and regenerative capacities, offering broad clinical promise in regenerative medicine. However, clinical application is constrained by low in vivo survival, poor targeting, variable efficacy, replicative senescence and insufficiently char... |
41799208 | Bimetallic Cu/Fe-MOF-based heterojunction sonozymes for triple amplification of sono-immunotherapy through activating tumor-specific cuproptosis and cGAS-STING pathway. | <h4>Background</h4>Initiating ROS-induced ICD and activating innate immune pathways are promising strategies for reprogramming immunosuppressive TME and eliciting persistent antitumor immune responses.<h4>Methods</h4>To realize the cascade amplification of antitumor immune response, we report for the first time a TME-r... |
41799184 | Recent advances of metal-organic frameworks (MOFs) for drug delivery, cancer imaging and theranostics. | Metal-organic frameworks (MOFs) are a unique class of porous materials constructed from metal-containing nodes, known as secondary building units (SBUs) and organic ligands. Their highly tunable structures enable the encapsulation of a broad range of therapeutic agents, spanning small-molecule chemotherapeutics to biom... |
41795542 | Deciphering the signal of metal ions: the principle, design and multi-field application of DNAzyme fluorescence sensor. | Metal ion detection is the core link of ecological protection, human health, and food safety. Traditional methods (AAS, ICP-MS, etc.) are expensive and cumbersome, and it is difficult to meet the needs of rapid on-site detection. In this paper, the research progress of DNAzyme fluorescence sensors is systematically rev... |
41789360 | Mapping the nonribosomal specificity code through promiscuity-guided A-domain engineering. | Nonribosomal peptide synthetases (NRPSs) assemble bioactive peptides from various building blocks. The binding pocket residues governing building block specificity have allowed prediction of NRPS products but not design of specificity. A reason for this failure has been ignorance of NRPS multispecificity. Here, we empl... |
41785758 | Solid-state NMR spectroscopy reveals polishing-induced supramolecular disorder in sake rice starch. | While the brewing suitability of sake rice is influenced by its structural features, the molecular basis of its starchy core (shinpaku) remains unresolved. Here, Yamadanishiki, a widely used sake rice cultivar, polished to 40% was characterized using solid-state nuclear magnetic resonance (NMR) spectroscopy, scanning e... |
41783295 | Burning Sensation and Facial Blood Flow in Rosacea Patients: An Exploration of an Invisible Symptom That Cannot Be Overlooked. | <h4>Background</h4>Rosacea presents with visible symptoms and subjective symptoms like burning and itching; among these, burning may seriously impairs patients' quality of life. Current research has focused primarily on visible manifestations, with insufficient attention given to studying subjective symptoms such as bu... |
41783089 | Tumor antigen only (TAO) vaccine platforms for glioblastoma therapeutics: a systematic review of evidence from clinical trials. | Glioblastoma is the most common form of primary brain tumor in adults, characterized by rapid progression and poor prognosis-despite the standard of care treatment including maximal safe resection, radiotherapy, and chemotherapy. Cancer vaccination has emerged as a promising strategy to harness the patient's immune sys... |
41780431 | Self-assembly of lipid corona on biocompatible gold nanoparticle suprastructures with plasmonic and theranostic functions. | Lipid-based carriers represent the leading technology for nanoparticle (NP) drug delivery. To this end, the incorporation of gold NPs into lipid coronas (LC) has long been of scientific and practical interest. However, challenges persist in confining the inorganic payload within the LC, while achieving high loading eff... |
41777379 | Inhalable Albumin Nanoparticles Co-Delivering Dihydroartemisinin and Nintedanib Attenuate Pulmonary Fibrosis by Suppressing TGF-β1/Smad2/3 Signaling. | <h4>Purpose</h4>Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by high morbidity and limited treatment options. Current antifibrotic agents, such as pirfenidone and nintedanib (NIN), are restricted by systemic toxicity and insufficient pulmonary targeting. This study aimed to develop a... |
41775157 | Renoprotective effects of perennial ryegrass attenuate UA mediated renal damage via modulating gut microbiota and anti-oxidative defense. | Hyperuricemia (HUA) is a metabolic disorder and a major cause of gout in geese, commonly exacerbated by concentrate diets rich in protein and calcium. Elevated uric acid (UA), a potent pro-oxidant, contributes to renal injury and is strongly influenced by dietary composition and gut microbiota. Therefore, research for ... |
41775087 | Nanoarchitectonics of penetrating peptide and anionic amphiphiles for dental plaque eradication. | Oral biofilm is the primary cause of a wide range of oral diseases, of which dental plaque represents a typical manifestation. To develop effective antibacterial agents for eliminating dental plaque is a huge challenge. Herein, a facile strategy by introducing cell-penetrating peptide octa-arginine (R8) into four anion... |
41775065 | A tri-responsive sensor based on co-encapsulated organic probes and multifunctional bimetallic V/Ce-MOF nanozyme in a hydrogel for the detection of l-Serine in saliva. | Rapid and accurate detection of l-Serine, a key potential biomarker of neurological diseases such as Alzheimer, Parkinson and Amyotrophic lateral sclerosis (ALS) disease, is crucial for public health. Herein, we prepared a tri-responsive sensor capable of colorimetric, fluorimetric, and electrochemical detection. This ... |
41769302 | Fluoroolefin-vinyl ether copolymer ionic fluorogels for PFAS remediation from water. | Per- and polyfluoroalkyl substances (PFAS) are a class of toxic chemicals that are ubiquitous in the environment and have contaminated water sources globally. As regulations limiting PFAS concentrations in drinking water are being established by regulatory agencies globally, there is an urgent demand for robust granula... |
41769037 | Enhanced visible-light-driven photocatalytic degradation of methylene blue and ciprofloxacin using magnetic NiFe<sub>2</sub>O<sub>4</sub>@ZIF 67. | Designing metal organic framework (MOF)-based stable heterostructures remains a challenging task for material scientists. Herein, a magnetic photocatalyst, designated 30NFZ67, was synthesized using a simple and green method by combining ZIF 67 and NiFe<sub>2</sub>O<sub>4</sub> at room temperature. The fabrication of a ... |
41769036 | Nanoencapsulation of <i>Rhodiola rosea</i> extract into 2-hydroxypropyl-β-cyclodextrin: enhanced antibacterial and anticancer activities. | The methanolic extract of <i>Rhodiola rosea</i> (RRME) exhibits multifaceted biological functions, notably antioxidant, anti-inflammatory, and neuroprotective potential. These properties are primarily associated with its rich therapeutic phytochemicals such as salidroside, rosavin, and tyrosol, which contribute to its ... |
41769035 | Hybrid polyurethane-MOF platform for turn-on fluorescent sensing of Cu<sup>2+</sup> ion. | The pervasive contamination of water resources by heavy metal ions poses serious threats to environmental safety and human health, creating an urgent demand for simple, sensitive, and selective sensing platforms. Herein, a robust polyurethane foam (PUF)-supported UiO-66-NH<sub>2</sub>-calcein composite is developed as ... |
41768421 | Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review. | <h4>Background</h4>Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene exp... |
41768140 | Computational and Experimental Characterization of <i>Mycobacterium marinum</i> β-Carbonic Anhydrase Inhibitors. | Carbonic anhydrases in <i>Mycobacterium tuberculosis</i> are increasingly recognized as promising therapeutic targets in drug-resistant tuberculosis. In this study, a homology model of β-carbonic anhydrase was developed using the closely related <i>Mycobacterium marinum</i> sequence as a structural basis. A focused ant... |
41767856 | In silico analysis of <i>Anacardium occidentale</i> phytochemicals: pharmacokinetics, molecular docking, and dynamics of <i>Cryptococcus neoformans</i> enzymes. | This study evaluated in silico the antifungal potential of phytochemicals from the leaves of <i>Anacardium occidentale</i> (cashew tree) against key enzymatic targets: farnesyltransferase (CnFTase), beta-carbonic anhydrase (β-CA), and adenylosuccinate synthetase (AdSS) from <i>Cryptococcus neoformans</i>. Molecular doc... |
41767812 | Peptide cages: bioinspired supramolecular architectures for next-generation applications. | This review examines the design and synthesis of peptide-based supramolecular cages, highlighting the versatility and functional diversity achievable by incorporating small peptides as structural components. Inspired by natural supramolecular architectures, synthetic peptide cages offer unique advantages, including tun... |
41767409 | <i>Pseudomonas aeruginosa</i> Biofilms in Cystic Fibrosis: Interactions, Methods, and Therapeutic Strategies. | This review explores the role of <i>Pseudomonas aeruginosa</i> biofilms in cystic fibrosis (CF) pathogenesis. Biofilms, the main bacterial lifestyle in CF lungs, are key in therapy failure, immune evasion, and chronic infection persistence. This review examines biofilm structure, emphasizing extracellular polymeric sub... |
41764954 | Controlled construction of hierarchical porous carbon catalysts with Co/CoFe interfaces via Zn sacrifice and Prussian blue analogue growth for oxygen evolution. | The development of non-precious metal catalysts for the oxygen evolution reaction (OER) is of great significance for advancing electrochemical overall water splitting (OWS). Herein, we report the synthesis of a hierarchically porous carbon catalyst embedded with cobalt nanoparticles and cobalt‑iron alloy (denoted as Co... |
41763418 | Ferritin iron uptake and oxidation are dynamically modulated by nucleotide phosphate architecture via electrostatic gating. | Ferritin safeguards cells from iron-induced oxidative stress by oxidizing and storing Fe<sup>2+</sup> within its nanocage, yet how its macromolecular architecture enables responsiveness to the cellular chemical environment remains unclear. Here, we show that ferritin's iron-oxidation activity is modulated by an electro... |
41763368 | Unlocking the potential of antimicrobial lipopeptides: a pathway to combat multidrug-resistant pathogens. | Antimicrobial lipopeptides (AMLPs) have emerged as a promising class of therapeutic agents against multidrug-resistant pathogens due to their unique amphiphilic structure and multimodal mechanisms of action. This review systematically summarizes the microbial origins and structural classification of AMLPs, elucidates t... |
41763347 | Potential of intranasal delivery of human mesenchymal stem cells and extracellular vesicles for stroke therapy. | Cerebral ischemic stroke, caused by interrupted cerebral blood flow, remains a leading cause of mortality and long-term disability worldwide. Current FDA-approved therapies-intravenous tissue-type plasminogen activator (tPA) and mechanical thrombectomy-are constrained by narrow time windows (4.5-24 h) and limited acces... |
41763310 | Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation. | Brucellosis is a widespread zoonotic disease caused by Brucella, a genus of facultative intracellular bacteria that infects livestock and humans. Brucella primarily replicates within the endoplasmic reticulum (ER) of host cells, where it establishes a specialized replicative niche. This ER localization disrupts ER stru... |
41763265 | Inducing ferroptosis and reversing immune evasion for the suppression of melanoma lung metastasis via neferine-loaded controlled-release system. | Although melanoma is sensitive to ferroptosis, the upregulation of programmed cell death ligand 1 (PD-L1) induced by ferroptosis contributes to immune evasion. This study demonstrates that Neferine (Nef) effectively inhibits PD-L1 expression in melanoma, reversing immune evasion induced by ferroptosis. Utilizing the co... |
41763117 | A multifunctional bimetallic MOF nanozyme orchestrating ferroptosis-apoptosis synergy for enhanced gastric tumor immunotherapy. | Nanozymes have revolutionized tumor therapy due to their distinctive enzyme-like catalytic properties. However, traditional nanozymes often face limitations, including inadequate targeting capabilities, limited catalytic efficiency, and low therapeutic efficacy of single-pathway mechanisms. Herein, we successfully deve... |
41762873 | Label-free fluorescence lateral flow biosensing platform based on host-guest recognition for on-site detection of amantadine in egg samples. | Rapid, accurate and convenient detection of illegally added drugs are of critical importance in food safety. Herein, based on the host-guest recognition strategy, we establish a novel label-free fluorescence lateral flow assay (LF-LFA) platform for detection of amantadine (AMD) in egg samples. Specially, two fluorescen... |
41762511 | Treating waste with Waste: Construction of a renovated composite adsorbent from waste polyurethane sponge for bisphenol purification. | Bisphenol contaminants (BPs) pose significant ecological and health risks. Transforming waste into functional adsorbents is crucial for sustainable development. This study valorizes waste polyurethane (PU) sponge into a ternary composite (PUDA@β-CD@EZ8) for efficient BP removal. The material ingeniously combines polydo... |
41759741 | Functions of prolyl hydroxylation in elastin. | Elastin is a key protein responsible for elasticity, resilience, and deformability of tissues. Elastin is subject to an understudied posttranslational modification, prolyl hydroxylation, where a hydroxyl group replaces a hydrogen atom at C-γ in proline residues during assembly. Recent experimental studies suggest elast... |
41759728 | PhuS conformational dynamics are essential for DNA binding and heme-responsive control of the prrF operon in Pseudomonas aeruginosa. | In Pseudomonas aeruginosa chronic infections, heme is a primary source of the essential micronutrient iron. The cytoplasmic heme-binding protein, PhuS, regulates extracellular heme flux through its interaction with the iron-regulated heme oxygenase (HemO). Additionally, in its apo-state, PhuS modulates iron homeostasis... |
41758641 | Protocol for the formulation and characterization of extracellular vesicle-crosslinked supramolecular hydrogels. | Extracellular vesicles (EVs) can serve as supramolecular crosslinkers to form injectable, intrinsically bioactive hydrogels. This protocol details the formulation, rheological characterization, and analysis of EV-crosslinked hydrogels with tunable mechanics. We describe steps for preparing alkyl-modified hydroxypropyl ... |
41755531 | Wafer-Scale Synthesis of Molecularly Engineered 2D Covalent Organic Framework Films for Highly-Sensitive and Rapid-Response Humidity Sensing. | Covalent organic frameworks (COFs) hold exceptional potential for humidity sensing due to their tunable chemical structure and high porosity, yet their uncontrolled relationships between molecular design, nanoscale architecture, and sensing performance have hindered their practical applications. Here, we report the rat... |
41749332 | FBR-NDs: a ferroptosis-inducing nanocomplex for targeted breast cancer therapy via immune modulation and redox-responsive drug delivery. | <h4>Background</h4>The aim of this study was to develop and characterize a novel ferroptosis-inducing nanocomplex, FBR-NDs (Fe³⁺-BMS-1-R848 Nanodrugs), and to evaluate its anti-tumor effects in breast cancer cells through induction of ferroptosis and modulation of immune responses.<h4>Methods</h4>FBR-NDs were synthesiz... |
41749300 | Chloroquine phosphate targets the MAPK-ERK pathway to inhibit ASFV SY-1 replication in vitro. | African swine fever (ASF) is a highly fatal disease caused by the African swine fever virus (ASFV). It infects domestic pigs and wild boars, causing significant economic losses worldwide. However, effective vaccines against this virus remain not be commercialized because of its large genome and high mutation frequency.... |
41749221 | Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury. | Spinal cord injury (SCI) remains difficult to treat, and current interventions provide limited functional restoration and often require invasive procedures. Existing cell- or extracellular vesicles (EV)-based approaches are frequently administered alongside surgery, limiting therapeutic reach and overall efficacy. In t... |
41749109 | Gene expression regulation by Ca<sup>2+</sup> signaling: an updated systematic review. | All life processes depend on the precise spatiotemporal expression of genes, which involves orderly processes including transcription, posttranscriptional processing, translation, and posttranslational modification. Accumulating evidence demonstrates that Ca<sup>2+</sup> is the most critical second messenger that orche... |
41749060 | Overlooked Complications and Opportunities in the Development of Drugs Based upon Macrobicyclic Peptides: The "Homeomorphic Switch". | Many macrobicyclic compounds can undergo a widely overlooked conformational process, homeomorphic isomerization, that effectively turns molecules inside-out and leads to species with <i>in,in</i>, <i>out,out</i>, <i>in,out</i>, and <i>out,in</i> bridgeheads. Different chemical and biological properties would be expecte... |
41748974 | Nanoparticle-based approaches for bacterial detection and therapy. | The advent of nanotechnology has revolutionised approaches to identifying and combating bacterial infections. This review highlights the latest applications of nanoparticles (NPs) for bacterial detection and treatment, with a focus on their translational potential in clinical settings. We discuss advanced nanotechnolog... |
41748967 | The effect of OsteoStrong compared to dynamic multicomponent exercise on bone strength in older women: the BONEMORE non-inferiority randomized controlled trial. | The efficacy of OsteoStrong® (OS) on bone strength is limited, and how it compares to dynamic multicomponent exercise (DME) is unknown. In this randomized controlled trial, the effect of OS on bone material strength index (BMSi) in older women was non-inferior to that of DME. No significant interaction between treatmen... |
41748904 | Relevance of polymorphisms in TLR2/4 genes and their association with plasma cytokines for schizophrenia. | Schizophrenia is associated with altered levels of plasma cytokines. Toll-like receptors (TLRs) can be responsible for cytokine synthesis. It remains unclear whether genetic changes in TLRs, e.g. single-nucleotide polymorphisms (SNPs), account for altered levels. Here, we investigate the relationship between SNPs in TL... |
41748863 | GO@CNT@Fe₃O₄@CuO quaternary nanohybrids enhance dielectric-magnetic synergy for high-performance epoxy-based electromagnetic absorbers. | This study introduces a novel quaternary GO@CNT@Fe₃O₄@CuO core-shell nanohybrid designed to overcome impedance mismatch limitations in electromagnetic (EM) absorbers. Through stepwise synthesis, we integrated dielectric (GO, CNT), magnetic (Fe₃O₄), and semiconducting (CuO) components to create synergistic loss mechanis... |
41748625 | A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor. | The human genome contains approximately 800 G protein-coupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, we show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemica... |
41748621 | Chiral peptidoglycan mimics target bacterial wall biosynthesis for pathogen intervention. | The global burden of microbial infections and antimicrobial resistance, coupled with the absence of precise bacterial recognition modalities, demands innovative breakthroughs in antibacterial treatment. Here, we report a chirality-specific biomimic-D-alanine-conjugated peptidoglycan mimics (D-PM)-designed for bacterial... |
41748612 | Precise regulation of missing linkers in MOF pervaporation membranes for desalination of hypersaline waters. | We report a method for the precise regulation of intracrystalline missing-linkers to control the permeability and selectivity of metal-organic framework (MOF) membranes. The method is applied for the design of stable ceramic-based MOF-801 membranes for hypersaline water treatment via pervaporation. For efficient membra... |
41748583 | Gear-like MOF microrobots for single cell mechanotransduction of microvilli. | Cellular mechanotransduction, mediated by specialized structures such as microvilli, regulates processes ranging from tissue homeostasis to disease progression. Existing tools for microvilli-specific biomechanical intervention suffer from limited spatiotemporal precision and non-physiological constraints, restricting m... |
41748567 | Navigating the complexities of ferroptosis in pancreatic ductal adenocarcinoma: roles, mechanisms and potential applications. | Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options and a profoundly immunosuppressive tumor microenvironment (TME). Ferroptosis, a novel form of regulated cell death driven by iron-dependent lipid peroxidation, has emerged as a promising therapeutic avenue by targeting metab... |
41748586 | Decoding local framework dynamics in the ultra-small pore MOF MIL-120(Al) CO<sub>2</sub> adsorbent using machine-learning potential. | Metal-organic frameworks (MOFs) with ultra-small pores offer an optimal environment to effectively capture guest molecules such as CO<sub>2</sub>. Subtle local dynamics of their frameworks, either throughout reorientation of functional groups grafted to the organic linkers or those present in their inorganic nodes, is ... |
41748578 | Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning. | Anxiety and mood disorders, notably major depressive disorder characterized by suppressed neuronal excitability, involve disruption of endogenous molecular polarity homeostasis. Conventional monoamine antidepressants, constrained by delayed therapeutic onset and high risk of drug resistance, neglect and fail to address... |
41748570 | Supramolecular coupling of cylindrical micelles following seeded-growth. | Macromolecular coupling is a widely used technique for industrial materials, while supramolecular coupling is ubiquitous in biological systems. Although the designed synthesis of one-dimensional self-assembled nanostructures via crystallization-driven self-assembly and liquid-crystallization-driven self-assembly has be... |
41748559 | Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol. | The mycotoxin deoxynivalenol (DON) poses severe threats to human and animal well-being globally. Enzymatic degradation is the most effective way to eliminate DON toxicity, yet no catalytic process for complete degradation of DON has been uncovered. Here, we show that a metabolic pathway initiated by C3-epimerization an... |
41748525 | Turning Rattling Motions from Phonon Scatterers to Thermal Conductivity Enhancers in Hydrogen-Bonded Organic Frameworks. | Conventional rattling motions of guest species in porous materials suppress the thermal conductivity by scattering phonons. Here, we demonstrate a paradigm shift: rattling can be engineered into a thermal conductivity enhancer. Using molecular dynamics and phonon analysis of a hydrogen-bonded organic framework (TCF-1) ... |
41748421 | Harnessing the Synergy of Ti<sub>3</sub>C<sub>2</sub>T<i><sub>x</sub></i>/CuO Nanocomposites and Charge Transport of FET-Based Transducers for High-Performance Sensing. | The rapid evolution of organic field-effect transistors (OFETs) as versatile sensing platforms has primarily focused on architecture and probe engineering, often overlooking the intrinsic role of charge carrier mobility (μ) in transduction performance. Herein, we present a systematic study that correlates μ of polymer-... |
41748346 | Severe elastic fiber fragmentation/loss is correlated with Marfan syndrome in patients with an ascending aortic aneurysm. | <h4>Context and objectives</h4>Aortic wall degeneration was described by a consensus statement published in 2016 by the Society for Cardiovascular Pathology (SCP) and Association for European Cardiovascular Pathology (AECP). The aim of this study was to determine if histopathologic features could predict the presence o... |
41748156 | "More" Artificial mRNAs: Beyond the Art of Nature. | Messenger RNA (mRNA) has emerged as a versatile platform for gene expression and therapeutic innovation. Early engineering efforts focused on optimizing canonical mRNA components-the 5' cap, untranslated regions, coding sequence, and poly(A) tail-to enhance stability, translational efficiency, and safety. These refinem... |
41748111 | A Supramolecular Organic Framework for Iodine Capture from Vapor and Solution. | Due to its high volatility and strong diffusion, iodine poses a serious threat to both the environment and human health, making the development of effective iodine capture materials an urgent priority. In this work, we present a supramolecular organic framework, C1, synthesized from <i>nor</i>-<i>seco</i>-cucurbit[10]u... |
41747263 | GSH-Activated Cu-TCPP(Zn)/Ti<sub>3</sub>C<sub>2</sub>T<sub><i>x</i></sub> Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma. | Photodynamic therapy (PDT) holds promise for oral squamous cell carcinoma (OSCC) but is limited by the tumor microenvironment─specifically hypoxia, elevated glutathione (GSH), and the lack of tumor-selective photosensitizer activation. To overcome these barriers, we developed a GSH-activated nanoplatform Cu-TCPP(Zn)/Ti... |
41747104 | Multinuclear Ruthenium Sites Confined in Metal-Organic Frameworks with Bio-Inspired Water Networks for Efficient Water Oxidation. | Natural enzymes achieve exceptional catalytic efficiency by organizing substrates within precisely defined microenvironments, a level of control that remains challenging to replicate in synthetic systems. Here we report an enzyme-inspired strategy in which a mononuclear Ru-cba water-oxidation catalyst is assembled into... |
41747096 | Synergistic Effects in a Homochiral Metal-Organic Framework Enable Enhanced Enantiomeric Discrimination and Ultrasensitive Detection of Disulfide-Containing Biomarkers. | The rational design of chiral interfaces that emulate the sophisticated recognition of biological systems remains a persistent challenge in sensing, demanding molecular recognition with high specificity and affinity. Progress in this area is crucial for advancing sensing capabilities, particularly in the precise quanti... |
41747077 | High-Performance Ternary Organic Solar Cells via Isomeric Engineering of Nonfullerene Guest Acceptors. | Constructing ternary blends has been considered as a feasible approach to achieve highly efficient organic solar cells; however, the delicate choice of the guest components still needs labor-intensive and time-consuming work. Herein, the isomeric effects of guest nonfullerene acceptor on the physicochemical and photovo... |
41747072 | Heterostructure Aerogels with a Hole-Rich Medium Enable Portable, Sub-ppb FeNO Detection toward Home Respiratory Care. | Two-dimensional conductive MOFs (2Dc-MOFs), with their large specific surface area and pore size, demonstrate great potential as chemiresistive gas sensors for the portable detection of exhaled biomarkers, which is crucial for the early diagnosis and management of respiratory diseases. However, their clinical applicati... |
41747057 | Organocatalyst-controlled stereoselective head-to-tail macrocyclizations. | Chiral macrocycles are key to the discovery of new medicines. Their synthesis is, however, challenging and typically requires the often-cumbersome installation of stereochemical features in a linear precursor. In this study, we report a catalyst-controlled stereoselective head-to-tail macrocyclization. The method utili... |
41747039 | A cellular basis for the mammalian nocturnal-diurnal switch. | Early mammals were nocturnal while dinosaurs dominated the daytime. Mammalian transition to daytime activity accelerated after the Cretaceous-Paleogene extinction, but the underlying mechanisms remain unclear. We identified a conserved cell-intrinsic, thermodynamic mechanism that likely facilitated this shift. In cells... |
41746998 | Immunoinformatics-driven design of multi-epitope vaccine targeting antibiotic-resistant Salmonella typhimurium. | Salmonella typhimurium, a Gram-negative bacterium, is a significant cause of gastroenteritis worldwide, with outbreaks occurring in diverse regions. Despite its global impact, there is currently no vaccine for human use against this pathogen. Complicating treatment efforts, S. typhimurium has exhibited resistance to mu... |
41746934 | Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches. | The rapid emergence of SARS-CoV-2 variants with spike protein mutations undermines the effectiveness of current vaccines, necessitating innovative strategies to ensure broad and lasting immunity. This study leverages an immunoinformatics approach to design two multi-epitope vaccine constructs Cov19-B (649 amino acids, ... |
41746725 | Mesophases as stepping stones to enhance crystallization kinetics in nanoparticle self-assembly. | Manipulation of kinetic pathways is essential to self-assemble nanoparticle building blocks into complex ordered structures, as the emergence of intermediate metastable states could either facilitate or hinder crystallization of the target lattice. Molecular simulations and Markovian and transition state theory are use... |
41744036 | Modulation of Peptoid Nanostructure for Antibiofilm Hydrogel Interfaces. | Most hospital-acquired infections originate from bacterial biofilms on implantable devices, where the extracellular polymeric substance (EPS) matrix protects microbes and promotes multidrug resistance (MDR). Preventing biofilm initiation, particularly bacterial adhesion and proliferation, offers an effective strategy t... |
41742896 | Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases. | Infectious diseases pose a critical global health threat, and rapid and sensitive diagnostics are essential for effective intervention. Conventional methods are often slow, costly, and require centralized instrumentation and trained personnel, limiting timely decision-making. Peroxidase-mimicking nanozymes (PMNs) have ... |
41742852 | Polyrotaxane-Assembled Semi-Interpenetrating Polymer Electrolytes Enabling High-Voltage Lithium Metal Batteries. | Polyether-based solid polymer electrolytes suffer from low ionic conductivity at room temperature, poor oxidative stability at high voltages, and susceptibility to dendrite growth, all of which hinder their application in high-energy-density lithium batteries. Herein, we report a polyrotaxane-assembled supramolecular s... |
41746673 | Asymmetric Three-Component Bolaform Giant Surfactants Exhibit Rich Unconventional Phases. | Self-assembly of block molecules into unconventional morphologies with ultrasmall feature sizes remains challenging. Here, we report the phase behavior of asymmetric bolaform giant surfactants, Si<sub>4</sub>-PS<sub><i>n</i></sub>-F, comprising a central polystyrene (PS) chain flanked by an oligodimethylsiloxane-functi... |
41746497 | Preclinical Evaluation of AHT-102, a CLDN18.2 × CD3 Bispecific Antibody: Pharmacokinetics, Anti-Tumor Efficacy, Tissue Distribution, and Safety Profile. | <h4>Background and objectives</h4>Claudin18.2 (CLDN18.2) is a promising therapeutic target overexpressed in various tumor tissues. While CD3-engaging bispecific antibodies show great potential, their clinical application is often limited by poor efficacy in solid tumors and significant safety risks, such as cytokine re... |
41746479 | Amine functionalized alumina supported metal-organic framework for wastewater treatment via adsorption and degradation of dyes; and for click reaction. | Metal-organic framework (MOF)-based composites have gained significant interest in various fields, particularly in catalysis and environmental remediation. In this study, CuBTC was immobilized on amine-functionalized alumina supports (1,2-en/Al<sub>2</sub>O<sub>3</sub>@CuBTC, 1,4-en/Al<sub>2</sub>O<sub>3</sub>@CuBTC, 1... |
41746480 | The cost of removing pollutants from water using magnetic nanoadsorbents. | Magnetic nanoparticles (MNPs) have enhanced the removal of pollutants from water to circumvent the drastic effects on the environment and living organisms. Despite their extensive application in water remediation studies, little is known about their cost analysis. This study comprehensively and critically discussed the... |
41746447 | The DNA mismatch repair protein Msh4 is essential for meiosis of male but not for female in zebrafish. | Meiotic recombination plays a crucial role in the correct separation of homologous chromosomes. The DNA mismatch repair protein Msh4 is a meiosis specific protein and msh4 defects were reported to associate with azoospermia and ovarian dysfunction in mammal. However, its role has not been elucidated in an important mod... |
41746256 | Multifunctional Guest-Hosting Triple-Stranded Helicates: From Anion Recognition to Quantum Information Applications. | ConspectusThe growing field of coordination supramolecular chemistry constitutes a fruitful avenue for accessing a variety of multifunctional materials with a range of applications. Their versatility is enhanced if they have the ability to encapsulate guest molecules, opening opportunities for host/guest synergies. One... |
41746206 | Two δ-catenins, plakophilin 4 and p120, promote formation of distinct types of adherens junctions. | Classical cadherins are instrumental for connecting cells into tissues by forming adherens junctions (AJs), a structurally diverse class of cell-cell adhesions tailored to specific membrane domains, cell types, and particular functions. The mechanisms that underlie the AJ diversification remain unknown. Here, we show t... |
41746187 | Bimodal Underwater Motion Monitoring Using Room Temperature Phosphorescent Zwitterionic Hydrogels Enabled by Salting-Out Ion-Induced Crystallization. | Hydrogels featuring excellent mechano-electric performance have been widely developed for intelligent robots. Nevertheless, realizing the accurate visualization of motion trajectories for intelligent control remains challenging, particularly in harshly interfering underwater environments. Herein, we present zwitterioni... |
41746143 | Programmable Pore Environments in Multivariate ZIF Membranes for Ultra-Selective Helium Recovery from Natural Gas. | Helium is an essential yet finite resource with critical applications in medical imaging and semiconductor manufacturing, whose production currently relies almost exclusively on energy-intensive cryogenic separation of trace helium from natural gas. Membrane-based separations offer an attractive alternative, but existi... |
41744473 | Cryo-EM structures of a MexB-MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain. | RND-type multidrug-efflux pumps are major contributors to multidrug resistance in Gram-negative bacteria, with MexY from Pseudomonas aeruginosa playing a central role in aminoglycoside resistance. Unlike other RND transporters, MexY exhibits unusually large open clefts in the binding and extrusion states. To determine ... |
41744393 | Simultaneous and Interference-Free Electrochemical Monitoring of Cd<sup>2<b>+</b></sup>, Cu<sup>2<b>+</b></sup>, and Hg<sup>2<b>+</b></sup> using a CoFe<sub>2</sub>O<sub>4</sub>@Fe-Pda MOF Composite. | There is a high risk of heavy metal contamination to both the environment and the population; hence, special care and selective, trustworthy detection technology is required. This paper describes the preparation and use of a CoFe<sub>2</sub>O<sub>4</sub>@Fe-Pda metal-organic framework (MOF)-based electrochemical sensor... |
41744274 | Structure first - exploration and discovery with cryo-electron microscopy. | The ability to directly observe living systems at finer levels of detail is a strong catalyst for biological discovery. This Perspective highlights how cryo-electron microscopy (cryo-EM) is enabling a 'structure-first approach' that can be harnessed for exploration and discovery at the molecular scale, as exemplified i... |
41744233 | Accelerated Turn-On and High Performance in Light-Emitting Electrochemical Cells Using Highly Charged Iridium Complexes. | Light-emitting electrochemical cells based on ionic transition metal complexes are attractive as efficient electroluminescent devices due to their simple, single-layer solution-processed architecture. One challenge for their operation is improving the response times of iridium iTMC LECs, which are highly efficient but ... |
41707245 | Room-temperature soliton-polariton condensation in a hierarchical helical-nanowire fractal gel. | We report the emergence and persistence of a room-temperature soliton-polariton condensate (SPC) within an organic supramolecular gel, formed through centimeter-scale, hierarchically nested helical nanowire circuits self-assembled from single molecules. We uncover a fractal feedback route, where nested interference and... |
41689844 | Peptide amphiphile nanofibers: advanced drug delivery platforms for cardiovascular therapeutics. | <h4>Introduction</h4>Cardiovascular disease is associated with significant morbidity and mortality worldwide. Current medical and surgical interventions have limitations related to side-effects and long-term efficacy. Hence, there is a need for novel therapeutics tailored specifically for cardiovascular disease. Peptid... |
41685905 | Chemoenzymatic synthesis of sulfated <i>O</i>-glycopeptides from human CD34. | <i>O</i>-Glycosylation is a key modulator of CD34 biofunction. To investigate the distinct roles of different glycoform modifications, we report an efficient chemoenzymatic strategy to rapidly assemble a library of CD34 <i>O</i>-glycopeptides bearing sulfated and sialylated glycan variants, enabling the elucidation of ... |
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