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41632595 | Integrating multi-structure covalent docking with machine-learning consensus scoring enhances potency ranking of human acetylcholinesterase inhibitors. | Acetylcholinesterase (AChE) inhibition is a key mechanism in the treatment of neurodegenerative diseases and in counteracting toxic exposures to pesticides and nerve agents. However, accurately ranking the potency of covalently binding AChE inhibitors remains challenging due to the enzyme's structural flexibility and t... |
41607222 | Graphs that predict exciton delocalization. | The field of molecular excitons and related supramolecular systems has largely focused on aggregates where nearest neighbour couplings dominate. We propose that radically different states can be produced by moving beyond that paradigm. In practice, accomplishing this task remains an open challenge because it requires t... |
41630354 | Associations of Albuminuria and Metabolic Syndrome Traits With Fracture Risk in Patients With Type 2 Diabetes: A Population-Based Cohort Study. | <h4>Background</h4>Type 2 diabetes is associated with an increased risk of fragility fractures. While obesity may protect against fractures, individuals with type 2 diabetes often exhibit other metabolic syndrome (MetS) traits and albuminuria. We evaluated their roles and synergistic implications on incident fractures,... |
41630343 | Exploring the mechanism of Jiaotai Pill in treating insomnia and erectile dysfunction based on network pharmacology, molecular docking, and molecular dynamics simulations. | Insomnia and erectile dysfunction (ED) exhibit a closely linked bidirectional association, often forming a vicious cycle. Current treatments focusing on single disorders show limited efficacy for this comorbidity. Jiaotai Pill, a classic traditional Chinese medicine formula, has shown potential in alleviating both cond... |
41630303 | Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study. | Alzheimer disease (AD) is a primary neurodegenerative disorder of the brain with an unknown cause and complex pathogenesis. It is the most common form of dementia and poses a significant threat to the health of the aging population worldwide. However, effective pharmacological treatments remain limited. This study empl... |
41626693 | AURKB-driven dissolution of CIZ1-RNA assemblies from the inactive X chromosome in mitosis. | Cip1-interacting zinc-finger protein 1 (CIZ1) interacts with Xist lncRNA to form large RNA-protein assemblies at the inactive X-chromosome (Xi) in female mammalian nuclei, plus smaller assemblies in both sexes. CIZ1 assemblies influence underlying chromatin, and their disruption alters the expression of autosomal and X... |
41619258 | pH-Responsive Isoprenoid-Antitumoral Polymer Conjugates for Superior Drug Loading via Self-Assembly and Endosomal-Targeted Anticancer Activity. | Polymer-drug conjugates (PDCs) are a promising strategy to enhance the delivery of poorly soluble drugs, particularly in cancer therapy. By improving solubility and enabling site-specific accumulation, PDCs minimize systemic toxicity while maximizing therapeutic efficacy. PDCs often employ stimuli-responsive linkers, s... |
41618958 | Phytochemical Screening of 45-Million-Year-Old Colored Angiosperm Leaves Reveals Distinctive Chlorophyll-Derived and Polyphenolic Pigments. | Present-day angiosperm plants produce a plethora of metabolites including pigments that serve for important functions such as photosynthesis, protection against light, attraction of pollinators, and defense against microbes and herbivores. However, little is known about phytochemical constituents of ancient angiosperms... |
41608624 | Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered <i>Bok</i> mRNA degradation. | Mitochondria-mediated apoptosis is the key determinant of glomerular podocyte injury. NOD-like receptor family pyrin domain proteins (NLRPs) are aberrant in clinical kidney diseases, but the role in podocyte mitochondrial dysfunction is unclear. Here, we first observed only NLRP6 expression change in nephrotic syndrome... |
41608587 | Polydopamine nanoparticles restore cognition via targeted dopamine delivery and septo-hippocampal cholinergic activation. | Altered dopamine (DA) neurotransmission in key brain circuits underlies cognitive deficits across psychiatric and neurological disorders by disrupting working memory, attention, and executive function. Here, we introduce a novel, carrier-free nanotherapeutic approach using polydopamine nanoparticles (PDA NPs)-synthesiz... |
41608580 | Nanomedicine in Organ Transplantation: From Graft Preservation and Repair to Immunomodulation and Monitoring. | Organ transplantation remains a life-saving intervention for end-stage organ failure. However, its long-term success has been constrained by a few critical challenges, including few noninvasive diagnostic technologies for graft assessment, a lack of effective organ preservation and rewarming techniques to mitigate isch... |
41608566 | From nanotags to precision biomedicine: SERS-driven progress and innovation in tumor biomarker profiling, dynamic bioimaging, AI-enhanced diagnostics and therapy. | Surface-enhanced Raman spectroscopy (SERS) has revolutionized molecular detection by exploiting the localized surface plasmon resonance phenomenon in noble metal nanostructures, achieving signal enhancement factors up to 10<sup>14</sup>. This transformative technology is reshaping biomedical practices through two funda... |
41608559 | STING signaling pathway: An oasis in the glioblastoma immune desert. | Glioblastoma (GBM) is an "immune desert" tumor, characterized by a highly immunosuppressive tumor microenvironment (TME), which leads to immune evasion and resistance to immunotherapies. The stimulator of interferon (IFN) genes (STING) signaling pathway serves as a central hub for priming anti-tumor immunity by driving... |
41608572 | Macrophage-biomimetic nanomedicine for targeted therapy of abdominal aortic aneurysm via Nrf2/NF-κB pathway. | <b>Rationale:</b> Abdominal aortic aneurysm (AAA) is a significant cause of death worldwide, with both mortality and incidence rates gradually increasing. Its complex pathological mechanisms hinder drug development. This work aims to develop a biomimetic multifunctional nanoparticle for targeted AAA therapy. <b>Methods... |
41608567 | <i>Hilnc-</i>mediated UCP1 translation repression contributes to thermogenesis and energy expenditure. | <b>Background</b>: Beige adipocytes play a critical role in thermoregulation by upregulating uncoupling protein 1 (UCP1) upon stimulation. While the transcriptional regulation of UCP1 in adipose tissue has been extensively investigated, the mechanisms governing its translational control remain largely elusive. <b>Metho... |
41608563 | Recent advances in nanoparticles targeting TGF-β signaling for cancer treatment. | Multiple therapies blocking TGF-β signaling have been investigated in preclinical and clinical trials over the past few decades; nevertheless, the outcomes of clinical trials are disappointing due to the double-faced systemic effects of TGF-β and the complexity of the tumor microenvironment. Intelligent nanodelivery sy... |
41608337 | Role of nanotechnology in modulating the tumor microenvironment to enhance immunotherapy efficacy. | The immunosuppressive tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is marked by hypoxia, acidity, and abundant stromal cells, such as cancer-associated fibroblasts, tumor-associated macrophages, and myeloid-derived suppressor cells, along with factors such as tobacco and alcohol exposure, human p... |
41607284 | From alkylating to shape-shifting G-quadruplex ligands: the RHAU peptide story. | G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures with important biological implications in telomere elongation and gene expression. A large number of small molecules have been developed to bind and even covalently target these structures, enhancing the potency and duration of binding. Alternativ... |
41615331 | Complexation of CaX<sub>2</sub> With nNH<sub>3</sub> (X = H, F; n = 1-3): Insight From Quantum Chemical and Vibrational Mode Analysis. | Quantum chemical methods are employed to investigate the complexation of CaX<sub>2</sub> with nNH<sub>3</sub> (X = H, F; n = 1-3). In the presence of CaX<sub>2</sub>, NH<sub>3</sub> molecules engage in several types of noncovalent interactions, namely, hydrogen bonding (HB), calcium bonding (CB), and dihydrogen bonding... |
41612978 | Carbon-13 Centerband-Only Detection of EXchange with Dynamic Nuclear Polarization. | The magic-angle spinning NMR technique, Centerband-Only Detection of EXchange (CODEX), can be used to determine the oligomerization state of molecules when combined with site-specific labeling. Calibrated with amino acid crystals, the method is successfully applied to proteins, primarily combined with <sup>19</sup>F la... |
41611291 | [Efficacy of sequential lateral position management in patients with chronic wounds and pulmonary complications: a prospective RCT]. | <b>Objective:</b> To investigate the efficacy of sequential lateral position management in patients with chronic wounds and pulmonary complications. <b>Methods:</b> This study was a prospective randomized controlled trial (RCT). From January 2023 to December 2024, 48 patients with chronic wounds and pulmonary complicat... |
41611288 | [Application of pectoralis major fascia in robotic nipple-sparing mastectomy with immediate breast reconstruction with gel implant]. | <b>Objective:</b> To preliminarily evaluate the feasibility, safety, and early aesthetic outcomes of using the pectoralis major fascia in robotic nipple-sparing mastectomy with immediate breast reconstruction with gel implant (RNSMIBR). <b>Methods:</b> This study was a retrospective cohort study. From November 2023 to ... |
41611235 | A C-Propeptide Variant in COL1A1 Potentially Perturbing Disulfide Bonding in Osteogenesis Imperfecta Type III. | Osteogenesis imperfecta (OI) is a genetic disorder characterized by bone fragility and frequent fractures. The disorder is caused by pathogenic variants in genes that encode type I collagen. The COL1A1 gene encodes the pro-α1(I) collagen chain, which assembles with another pro-α1(I) chain and one pro-α2(I) chain to for... |
41610024 | An Autologous, Vascularized and Immunocompetent Tissue Engineered Skin to Highlight Inter-Individual Variability to Better Understand the Human Wound Healing. | In vitro tissue-engineered skin models are valuable tools for dermatological research. Yet, they often fail to reproduce the complex interactions among vascular, immune, and cutaneous cells during the wound healing process. In addition, inter-individual variability response remains poorly understood, limiting our knowl... |
41606271 | The Role of Architectural Forces in Ion Selectivity. | A theoretical framework is presented to clarify the role of architectural and structural forces in ion selectivity. It expresses the relative free energy of bound ions in terms of a reduced subsystem corresponding to the local degrees of freedom coupled to the rest of the protein. The latter is separated into a first c... |
41604325 | Harnessing apidaecin capability to improve intestinal health and inhibit Salmonella Typhimurium transmission in laying hens. | Apidaecin (Api), an antimicrobial peptide, exhibits in vitro efficacy against Salmonella Typhimurium (S. Typhimurium) and enhances broiler growth performance via modulation of intestinal barrier function. This study evaluated the effects of dietary apidaecin on intestinal health in laying hens and its potential to miti... |
41604285 | From fitness to fate: Hippo-YAP-mediated cell competition influence on stem cells activity. | Cell competition is a fundamental quality-control mechanism where fitter 'winner' cells eliminate less-fit 'loser' counterparts, thereby fine-tuning cell populations during development and maintaining adult tissue integrity. This highly conserved, natural cellular process is absolutely crucial for organogenesis, but on... |
41603734 | The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments. | Human RAD52 is a prime target for synthetic lethality approaches to treat cancers with deficiency in homologous recombination. Among multiple cellular roles, RAD52's functions in homologous recombination repair and stalled replication fork protection appear to substitute for those of the tumor suppressor protein BRCA2.... |
41603553 | One-Step Facile Synthesis of Fused All-Carbon Cyclododecadiene and Cyclohexadecatetraene. | All-carbon macrocyclic compounds are useful chemical components for drug molecules, nanomaterials, and catalyst supports. The access of macrocyclic compounds is trapped in the absence of efficiency and flexible synthetic approaches besides obtaining from natural products. In this study, the first case of synthetic fuse... |
41603554 | Pseudomonadota bridge cross-trophic interactions to suppress plant pathogens. | Trait-mediated interactions across trophic levels drive trophic cascades in macroecological systems, yet their relevance in microbially dominated soil ecosystems remains underexplored. We combined a regional field survey with controlled experiments using a defined 122-strain synthetic bacterial community and bacterivor... |
41603486 | Advances in Synchrotron Radiation-Based Vacuum-Ultraviolet Circular Dichroism for Biomolecular Structural Analysis. | Vacuum-ultraviolet circular dichroism (VUVCD) spectroscopy using synchrotron radiation is a powerful tool for characterizing the structures of biomolecules in aqueous solutions. When combined with bioinformatics, VUVCD enables detailed determination of protein secondary-structure contents, segment numbers, and sequence... |
41603260 | Surfactant Derived From Stearoyl Chloride and Benzimidazole for Micellar-Promoted Synthesis of N-Aryl-1,8-dioxo-decahydroacridines in Water at Room Temperature. | In this article, a new anionic surfactant was prepared through a one-pot reaction of stearoyl chloride and benzimidazole with aluminum chloride under reflux conditions. Its structure was confirmed by <sup>1</sup>H and <sup>13</sup>C Nuclear magnetic resonance (NMR) analysis and Fourier transform infrared spectroscopy. ... |
41603241 | Proton Conduction in Metal-Containing Supramolecular Polymers and Hybrid Materials: Recent Advance and Future Challenges. | Among various alternative renewable energy resources, the proton exchange membrane fuel cell (PEMFCs) is considered a promising one. Proton exchange membrane (PEM) that serves as an inevitable part of PEMFCs requires to have high proton conductivity and minimum electrical conductivity. Until now, different organic, ino... |
41603039 | The Rippled Beta-Sheet: An Old Prediction Inspires a New Field. | The rippled β-sheet was predicted by Linus Pauling and Robert Corey in 1953. Unlike the closely related pleated β-sheet, which rapidly expanded to become common textbook knowledge, the rippled β-sheet remained obscure for decades. The critical body of biophysical evidence for the structural viability of this neglected ... |
41601402 | Recombination and Retroprocessing in Broomrapes Reveal RNA-Mediated Gene Transfer Mechanism and a Generalizable Model for Mitochondrial Evolution in Heterotrophic Plants. | The altered life history strategies of heterotrophic organisms often leave a profound genetic footprint on energy metabolism related functions. In parasitic plants, the reliance on host-derived nutrients and loss of photosynthesis in holoparasites have led to highly degraded to absent plastid genomes, but its impact on... |
41601364 | <b>TRPV1: from structure to function</b>-<b>a multidimensional target for therapeutic advances</b>. | Transient receptor potential vanilloid subtype 1 (TRPV1), a polymodally activated, calcium-permeable non-selective cation channel, is broadly present in all parts of the body, with notable expression in the nociceptive neurons. Both physiological and pathological functions rely heavily on this ion channel, mediating re... |
41599687 | Dihydroartemisinin Promotes N1 Polarization of Tumor-Associated Neutrophils and Enhances Their Anti-Tumor Activity via Hub Gene Modulation. | <b>Background</b>: Tumor-associated neutrophils (TANs) exhibit remarkable functional plasticity within tumor microenvironment (TME), with N1-like subtypes promoting anti-tumor immunity and N2-like subtypes facilitating tumor progression. Despite their critical role in cancer immunology, strategies to selectively modula... |
41599684 | Natamycin in Food and Ophthalmology: Knowledge Gaps and Emerging Insights from Zebrafish Models. | Natamycin, a polyene macrolide antifungal, has long been used as a food preservative and is the only Food and Drug Administration (FDA)-approved topical treatment for fungal keratitis. While its safety is supported by specific ergosterol interaction and minimal systemic absorption, current research mainly focuses on sh... |
41599169 | Advancing Tuberculosis Treatment with Next-Generation Drugs and Smart Delivery Systems. | Tuberculosis (TB) remains a leading infectious killer, increasingly complicated by multidrug-resistant (MDR) and extensively drug-resistant (XDR) disease; current regimens, although effective, are prolonged, toxic, and often fail to reach intracellular bacilli in heterogeneous lung lesions. This narrative review synthe... |
41599167 | Quality by Design for the Nanoformulation of Cosmeceuticals. | Cosmeceuticals are cosmetic formulations that are intended to alleviate skin conditions that affect its appearance and functionality. They are not considered medications but contain molecules that exert biological action on the skin beyond traditional cosmetic actions. Sometimes, the bioactives used have limitations fo... |
41594073 | Smart Healing for Wound Repair: Emerging Multifunctional Strategies in Personalized Regenerative Medicine and Their Relevance to Orthopedics. | To address the challenges in wound healing, clinical management increasingly demands targeted, adaptive, responsive, and patient-centered strategies. This is especially true for wounds characterized by delayed healing and a high risk of infection. Advances in regenerative medicine and biomaterial technologies are foste... |
41592740 | Spotted: RIPK3 and MLKL assembling necroptotic complexes. | Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) signalling, culminating in the activation of the pseudokinase mixed lin... |
41592533 | Investigation of synaptic connectivity in functional in vitro neuronal assemblies. | Studies using genetic tagging and optogenetics demonstrated that reactivation of memory engrams, neuronal ensembles encoding specific learned information, can trigger memory recall and that synaptic potentiation among engram neurons is critical for memory persistence. However, the complexity of intact brain networks ha... |
41591840 | NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes. | The nuclear pore complex (NPC) is composed of multiple nucleoporins (NUPs) and enables the exchange of RNA and proteins between the nucleus and cytoplasm. NUP98 is one of the major components of the NPC, being involved in the RNA export pathway by interacting with several transport factors. Previous studies have sugges... |
41591755 | Photo-Driven CO<sub>2</sub> Reduction With a Heterogenized Re Catalyst in the Metal-Organic Framework PCN-777: Effects of Catalyst Loading and Anchoring Strategy on Catalysis. | This study explores the impact of (i) different installation modes of the molecular rhenium catalyst Re within the PCN-777 metal-organic framework (MOF) and (ii) catalyst loading on the resulting catalytic performance and recyclability of the different hybrid materials in the photocatalytic reduction of CO<sub>2</sub> ... |
41591171 | Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds. | Venom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource. Omics-driven discovery and structural biology have expanded the pept... |
41590853 | Precision Profiling of the Cardiovascular Post-Translationally Modified Proteome. | Proteins exist as multiple chemical and sequence-specific proteoforms, each of which may serve as a critical mediator of physiological or pathological signalling. This diversity arises from processes such as alternative splicing of gene transcripts, translation into amino acid sequences, and various post-translational ... |
41590795 | The Role of Silver and Silver-Based Products in Wound Management: A Review of Advances and Current Landscape. | The urgent need for silver-based antibacterial agents in clinical settings has driven the diversification of their delivery systems, evolving from traditional silver salt preparations to new silver nanoparticles (AgNPs) and silver-based composite functional materials. Research and application of various carrier systems... |
41590718 | A Structure-Based Deep Learning Framework for Correcting Marine Natural Products' Misannotations Attributed to Host-Microbe Symbiosis. | Marine natural products (MNPs) are a diverse group of bioactive compounds with varied chemical structures, but their biological origins are often misannotated due to complex host-microbe symbiosis. Propagated through public databases, such errors hinder biosynthetic studies and AI-driven drug discovery. Here, we develo... |
41590647 | Metabolomics and Transcriptomics Reveal the Effects of Fermented <i>Lycium barbarum</i> (Goji) Berry Residue on Muscle Nutrition and Flavor Quality in Fattening Tan Sheep. | <h4>Background/objectives</h4>In the context of increasing consumer demand for high-quality meat, this study aimed to evaluate the effects of 4% fermented goji berry residue supplementation on meat quality and flavor characteristics in finishing Tan sheep.<h4>Methods</h4>Thirty-six male lambs were randomly assigned to ... |
41590572 | Efficient Separation of Per- and Polyfluoroalkyl Substances (PFAS) by Organic Framework Membranes: Advances, Mechanisms, and Challenges. | Per- and polyfluoroalkyl substances (PFAS) represent a class of highly persistent environmental contaminants with exceptional chemical stability. Efficient removal of PFAS from water poses a significant challenge for the chemical industry and constitutes a critical requirement for sustainable environmental development.... |
41590573 | Nanotube Alignment and Surface Chemistry in Altering Water and Salt Permeabilities for Imogolite-Polyamide Membranes. | Reducing the specific energy consumption of reverse osmosis (RO) processes motivates the development of new membrane materials that have enhanced water permeability while maintaining low salt permeability (high rejection). Nanocomposite membranes have shown great promise in achieving these goals, particularly those usi... |
41590279 | Recent Advances in Wearable Biosensors for Human Health Monitoring. | As the healthcare system transitions from traditional hospital-centered care to point-of-care and home-care systems, the demand for wearable sensors is increasing rapidly due to their ability to continuously monitor human health and support medical diagnostics [...]. |
41590285 | Potentiodynamic Fabrication of Aromatic Diamine Linkers on Electrochemically Reduced Graphene Oxide Surface for Environmental Pollutant Nitrobenzene Monitoring. | The structure of self-assembled monolayers (SAMs) greatly influences electrochemical interface behavior. This study systematically examines how positional isomers of aromatic diamines (ADMs) assemble on a glassy carbon (GC) electrode and how such ordering affects the attachment and performance of electrochemically redu... |
41590281 | Magnetic Europium Ion-Based Fluorescence Sensing Probes for the Detection of Tetracyclines in Complex Samples. | Eu<sup>3+</sup> is a fluorescent and paramagnetic ion whose emission intensity increases when chelated with enhancers such as tetracycline (TC). In this study, Eu<sup>3+</sup> was conjugated with citric acid (CA) to form magnetic fluorescent probes capable of capturing trace TC from solutions. The probes were rapidly p... |
41588733 | Microalgae-Derived Metal Nanostructures: Biosynthesis, Characterization, and Applications. | The exploration of green chemistry approaches for novel nanoparticles derived from microalgae presents a promising frontier in the realm of biomedical applications, harnessing the unique properties of these microorganisms for innovative solutions in healthcare. Microalgae, mainly due to their rapid growth rates and abi... |
41588681 | The V-Shaped Hamilton Receptors: A Paradigmatic Multipurpose Scaffold. | Sensors are devices that can detect and enumerate the physical and/or chemical aspects in real time. The generation of novel sensory materials for sensing/recognition of chemical entities are significant for protecting both the environment and humanity. This review article reveals the achievements made in the designed ... |
41588528 | Selective Acidic CO<sub>2</sub> Electroreduction to Methane Using Crown Ether-Functionalized Copper-Based Electrodes. | CO<sub>2</sub> electroreduction (CO<sub>2</sub>R) using Cu catalysts under acidic conditions currently receives substantial attention as it allows to limit detrimental (bi)carbonate salts formation and precipitation. However, it usually requires high concentrations of K-based electrolytes for suppressing hydrogen evolu... |
41588481 | Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review. | Resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) is a natural polyphenolic compound with notable antioxidant, anti-inflammatory, and immunomodulatory properties. It has been investigated for therapeutic applications in cardiovascular disease, cancer, and neurodegenerative disorders. This review emphasizes the potent... |
41587754 | Solid-state nanopore sensing reveals conformational changes induced by a mutation in a neuron-specific tRNAArg. | We demonstrate that solid-state nanopore sensing is a powerful single-molecule method for analyzing RNA conformational ensembles. As a model, we employed n-Tr20, a neuron-specific cytoplasmic tRNA$_{\mathrm{UCU}}^{\mathrm{Arg}}$, whose C50U mutation is associated with neurodegeneration in C57BL/6J mice. Maturation of t... |
41587385 | An Investigation of the Interfacial, Self-Assembly, and Antifungal Properties of Novel Symmetric Cationic Bolaamphiphiles. | Cationic bolaamphiphiles or bolaforms have gained significant attention due to their unique self-assembly behavior and potential applications in biomedical science. In this study, we have synthesized two novel cationic bolaamphiphiles, C<sub>12</sub>-(2-(4-carbamoylpiperazin-1-yl)pyridin-1-ium chloride)<sub>2</sub> [C<... |
41586680 | Giant Reversible Piezoelectricity from Symmetry-Governed Stochastic Dipole Hopping. | Organic-inorganic hybrid perovskites with giant piezoelectric responses, exemplified by TMCM-CdCl_{3}, represent a promising platform for flexible and environmentally friendly electromechanical materials. However, the microscopic origin of such exceptional performance in this weakly polar system has remained elusive. H... |
41586559 | Tuning thermodynamics and electronic properties of 1-hexyl-3-methylimidazolium based organic ionic liquids with iron porphyrin. | Ionic liquid-iron porphyrin (IL-FeP) complexes are systems with diverse applications, particularly in oxygen reduction reactions and the biodegradation of ionic liquids by cytochrome P450 enzymes, where FeP serves as the active site. Despite the importance of such systems, there is currently a lack of information on th... |
41585665 | Drug Delivery System for the Anticancer Drug Paclitaxel Using Lipocalin-Type Prostaglandin D Synthase Conjugated to a Tumor-Targeting Peptide. | Many drugs currently under development tend to have poor water solubility and large molecular weights, necessitating the development of systems for solubilizing and delivering these drugs to lesion sites. In this study, we attempted to utilize lipocalin-type prostaglandin D synthase (L-PGDS), which has a typical β-barr... |
41582717 | Bile Acids as Key Mediators of the Gut Microbiota-Immune Axis: Potential Biomarker and Therapeutic Perspectives. | Bile acids (BAs), long recognized for their role in lipid digestion, have recently emerged as key signaling molecules at the interface of host metabolism, immunity, and gut microbiota (GM). BAs are synthesized in hepatocytes and subsequently extensively modified by microbial enzymes in the gut, producing a diverse and ... |
41582644 | Electron Paramagnetic Resonance Spectroscopy Reveals Promoter Dependent Transcription Regulation by Copper Activated CueR in Pseudomonas aeruginosa. | Metal responsive transcription factors are essential for bacterial metal homeostasis, allowing cells to regulate metal uptake, efflux, and detoxification in response to fluctuating metal ion levels. Among these, CueR, a member of the MerR family, is widely found in Gram-negative bacteria. While E. coli CueR has been ex... |
41582442 | Structure-Response Relationships in Rigid C<sub>2</sub>-Symmetric Excitonic Systems: Principles, Modulation, and Functional Design Strategies. | Exciton coupling model provides one of the most intuitive and powerful frameworks to directly connect molecular structure with chiroptical responses. This review focuses on rigid architectures with C<sub>2</sub> symmetry, in which conformational rigidity, symmetry constraints, and independent chromophores allow for dir... |
41582303 | Evaluation of ASC as a therapeutic target for Alzheimer's disease. | Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis-associated speck-like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key... |
41579380 | Differences in photosystem II activity and carbon allocation during photomixotrophic growth in distinct wild-type strains of Synechocystis sp. PCC 6803. | The regulation of photosynthetic electron transport during photomixotrophic growth in cyanobacteria remains incompletely understood. In this study, we characterized four wild-type strains (WT 1-4) of Synechocystis sp. PCC 6803 and observed distinct strain-specific differences in photosystem II (PSII) function under pho... |
41578976 | Quality Analysis and Detection of Adulterants and Contaminations in Milk/Milk Powder by Raman Spectroscopy. | Milk and milk powder are central to global nutrition, yet remain vulnerable to adulteration and contamination. Adulteration using water, urea, ammonium sulfate, thiocyanates, detergents, melamine, or compositional changes with whey and carbohydrate fillers undermines nutritional quality, reduces consumer confidence, an... |
41577909 | Blood Flow Regulates Metabolism in Hematopoietic Development. | Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of... |
41575319 | Identification of Novel Growth Factor Conjugated Nanofibers for Stimulation of Neuronal Growth. | Growth factors (GF) fulfil essential functions during organ development and regeneration. In tissue regeneration, evidence suggests that the combined application of several GFs is more efficient compared to their individual application. Single or multiple GFs are often applied to animal models of organ regeneration thr... |
41574932 | Gamma-band cortical functional network abnormalities in late-life depression with suicidal ideation: insights from EEG graph theory and machine learning. | <h4>Background</h4>Late-life depression (LLD) is the major risk factor for elderly suicide, and suicidal ideation (SI) is a crucial stage for prevention. However, LLD are less likely openly express SI. Gamma oscillations, closely linked to cognition and mental processes, may contribute to the pathophysiology of LLD and... |
41574808 | Supramolecular cooperativity through the lens of enhanced sampling molecular dynamics. | Supramolecular polymers are dynamic aggregates whose properties arise from their constitutive bonds, based on reversible, non-covalent interactions. A central aspect in the design and function of these materials is the cooperativity of polymerization, by which the addition of monomers becomes increasingly favorable as ... |
41574799 | Structural and compositional complexities of hierarchical self-assembly: A hypergraph approach. | Programmable self-assembly enables the construction of complex molecular, supramolecular, and crystalline architectures from well-designed building blocks. We introduce a hypergraph-based formalism, Blocks & Bonds (B&B), which generalizes classical chemical graph theory by incorporating directed and multicolored intera... |
41574459 | CysDuF database: annotation and characterization of cysteine residues in domain of unknown function proteins based on cysteine post-translational modifications, their protein microenvironments, biochemical pathways, taxonomy, and diseases. | Experimental characterization and annotation of amino acids belonging to domains of unknown function (DUF) proteins are expensive and time-consuming, which could be complemented by computational methods. Cysteine, being the second most reactive amino acid at the catalytic sites of enzymes, was selected for functional a... |
41572964 | Manganese Oxide as an Electrochemical Sensor for Carbamazepine and Sulfamethoxazole in Wastewater Samples. | The extensive use of pharmaceutical compounds poses a growing threat to environmental and public health. Carbamazepine (CBZ) and sulfamethoxazole (SMX), widely used in veterinary and human medicine, are persistent pollutants often detected in water bodies. Their presence at trace levels can contribute to the developmen... |
41572840 | Amphiphilic Cu(II) Oxacyclen Complexes: From Oxidative Cleavage to Condensation of DNA. | Cu(II) complexes with monoalkylated oxacyclen ligands (C<sub>12</sub>, C<sub>16</sub>, and C<sub>18</sub>) have been investigated regarding their interaction with DNA by different methods: circular dichroism, UV/VIS (ultraviolet-visible) and fluorescence spectroscopy as well as by gel electrophoresis. The results demon... |
41572565 | Systematic Identification and Recognition Analysis of Beta1-Adrenergic Receptor Targeting Material Basis in Tibetan Medicine Formula Bawei Chenxiang Powder. | Bawei Chenxiang Powder (BWCP) is a Tibetan medicine formulation used to treat cardiovascular diseases, has demonstrated clinical efficacy though its material basis remains unclear. In clinical trial, β<sub>1</sub>-adrenergic receptor (β<sub>1</sub>-AR) has been recognized as a key therapeutic target in cardiovascular d... |
41569151 | Structural plasticity enables broad cAn binding and dual activation of CRISPR-associated ribonuclease Cdn1. | Prokaryotes have naturally evolved diverse RNA-guided defense systems against viral infections, with the type III CRISPR-Cas systems representing the most intricate. These systems feature accessory proteins activated by cyclic oligoadenylates (cOAs) produced upon target RNA recognition, synergizing with the CRISPR-Cas ... |
41568808 | A coarse-grained, coupled oscillator toy model to describe low-frequency lattice-like vibrations of β-sheets in amyloid fibrils. | We present a coupled-oscillator toy model that describes the low-frequency lattice-like vibrations observed in Raman and inelastic neutron scattering spectra of amyloid fibrils, silks, and other proteins that are rich in β-sheet structures. In this model, the strands of the β-sheets are treated as harmonically oscillat... |
41568805 | Hierarchical MXene/ACF/Ni-MOF ternary composites: Rational design and enhanced supercapacitive performance. | Composite nanomaterials MXene/ACF/Ni3(HITP)2 with a three-dimensional network structure were synthesized using two-dimensional MXene nanosheets and one-dimensional structured acidified activated carbon fiber (ACF) as substrates. This design aims to enhance the specific surface area of the composites, expose more active... |
41566659 | HPLC Chiral Separation and Elution Reversal Mechanism of a Typical Light-Driven Molecular Motor, 1-(9H-Fluoren-9-Ylidene)-2,3-Dihydro-2-Methyl-1H-Benz[e]Indene. | 1-(9H-Fluoren-9-ylidene)-2,3-dihydro-2-methyl-1H-benz[e]indene (short as FMB) as one of second-generation light-driven molecular motors contains a chiral carbon atom, and has attracted considerable attentions due to macroscopic chiral structures and light-driven behaviors through supramolecular assembly and cooperative... |
41565592 | Anti-Stokes Shift Induced by Photoinduced Intramolecular Proton Transfer in a Covalently Linked Phthalocyanine-Phenothiazine Dyad. | We have synthesized and characterized two covalently linked proton donor-acceptor supramolecular compounds: phthalocyanine-phenothiazine. These compounds exhibit an unexpected anti-Stokes shift. To elucidate the underlying mechanism, we investigated their UV-vis absorption spectra, steady-state fluorescence excitation ... |
41565591 | Synthesis and Studies of Pyrene-Embedded Stable Nonaromatic Dithiaheptaphyrin(1.0.0.1.1.2.1)s. | We report the synthesis of three novel 1,4-pyrene-embedded heptaphyrins in 5% yields via a [5 + 2] condensation of 1,4-pyrene pentapyrrane with dipyrromethene diols under mild acid-catalyzed conditions, followed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) oxidation. The key precursors, 1,4-pyrene pentapyrrane an... |
41564868 | Targeting severe acidity for tumor-activatable Interleukin-2 therapy. | Interleukin-2 (IL-2) is a cytokine with curative potential in cancer immunotherapy, but its clinical use is limited by a narrow therapeutic window. Traditional strategies such as polarizing receptor binding or fusing IL-2 with Fc (IL-2-Fc) improve pharmacokinetics and immune selectivity, but systemic toxicity remains a... |
41564859 | Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) features a tumor immunosuppressive microenvironment (TIME) and limited response to immune checkpoint inhibitors (ICIs). To address this, we develop ultrasound-responsive nanoparticles by encapsulating PD-L1-targeting small interfering RNA (siRNA) and sonodynamic metal-organic frameworks (... |
41563143 | Comprehensive Analysis of PAPPA2 Expression and Genetic Variants in Sheep and Their Association With Litter Size. | <h4>Background</h4>The PAPPA2 gene encodes a metalloproteinase critical for regulating insulin-like growth factor (IGF) bioavailability through cleavage of insulin-like growth factor-binding protein 5 (IGFBP5). While its role in human and murine reproduction is documented, its function in sheep reproductive traits rema... |
41562201 | Hybridization of Hydrophilic-Hydrophobic Balanced Polyimide Membranes With Nanoporous Entities (TiO<sub>2</sub>, SiO<sub>2</sub>, and MOF) for Efficient Removal of Neurotoxic Organic Solvents and Oil From Wastewater. | The growing global concern over oily wastewater pollution necessitates the development of advanced and efficient separation technologies. In this study, polyimide (PI) based mixed matrix membranes were fabricated by incorporating SiO<sub>2</sub>, TiO<sub>2</sub>, and metal organic frameworks (MOFs) into a polyethersulf... |
41561616 | Multiscale Three-Dimensional Vertical Graphene-Encapsulated Nanoparticle Coatings for Antibacterial Applications against Multidrug-Resistant Bacteria. | Implant-associated infections caused by multidrug-resistant <i>Staphylococcus aureus</i> (<i>S. aureus</i>) remain a major clinical challenge, underscoring the urgent need for surface-engineered antibacterial strategies that extend beyond conventional antibiotic delivery. Here, we report a hierarchical antimicrobial co... |
41560636 | Phase Change Materials-Based Biodegradable Packaging for Perishable Food. | The rising global concern over food waste-particularly from highly perishable commodities-highlights the urgent need for sustainable and reliable cold chain packaging solutions. A substantial quantity of food is wasted every year during supply chain operations due to fluctuations in optimal temperature and moisture con... |
41557241 | Designability of α-Helical Protein Filaments. | Helix-helix interactions are mediated through highly designable interfaces within tertiary and quaternary structures of proteins and protein assemblies. The structural regularity of these interfaces suggests that ordered self-assembled structures could be constructed from implementation of these interactions between ap... |
41556345 | A noncanonical transcriptional regulation in natural product biosynthesis. | TenA (transcription enhancement) family proteins are widespread in bacteria, yet their functions in regulating natural product biosynthesis remain largely unexplored. Here, we report that LysR2, a TenA-family protein encoded by the lysolipin I biosynthetic gene cluster, acts as a transcriptional activator. Genetic and ... |
41556155 | Genetic Diversity of Polymyxin Resistance Genes in Klebsiella pneumoniae Clinical Isolates. | This study investigates the genetic diversity and evolutionary mechanisms driving polymyxin resistance in Klebsiella pneumoniae, a critical priority pathogen. By analysing mgrB, phoPQ and pmrAB genes in susceptible (PM-S) and resistant (PM-R) populations through neutrality tests (Tajima D, Fu & Li's D) we uncovered pol... |
41555779 | Quantum medicine: A quantum-mechanical framework for redox biology, disease and precision medicine. | <h4>Background</h4>Key biological processes underlying health and disease-including electron transfer, redox regulation, and radical-mediated signaling-are fundamentally governed by quantum-mechanical principles. These processes are central to mitochondrial function, metabolism, and cellular signaling, yet their biomed... |
41555729 | Scent Goes Digital: The Role of Insect Odorant Binding Proteins in Modern Technology. | Researchers have developed hybrid bionic platforms for odor detection, inspired by natural chemoreceptive systems, advancing artificial olfactory systems that recognize specific volatile compounds. Odorant binding proteins (OBPs) are small carrier proteins found in the olfactory organs of mammals and insects. When coup... |
41555571 | Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry. | Interest in piperazine scaffolds continues to rise due to their broad relevance across anti-infective, anticancer, and neuroactive research. This review examines reports published from 2014 to 2024 and organizes current developments by therapeutic class, structural modification strategy, and computational assessment. S... |
41555099 | An apoplastic Lasiodiplodia theobromae effector triggers plant immunity through a lectin receptor-like kinase in peach. | Pathogen-associated molecular patterns (PAMPs) are recognized by plant pattern recognition receptors, activating PAMP-triggered immunity to restrict pathogen infection. The fungal pathogen Lasiodiplodia theobromae poses a major threat to global agriculture, yet its PAMPs and their interaction with plant pattern recogni... |
41554053 | An effective fragment-based dual conditional diffusion framework for molecular generation. | Fragment-based molecular generation has emerged as a promising paradigm in structure-based drug design (SBDD), deriving effective compounds with advanced properties, including chemical validity, synthetic feasibility, pharmacological relevance, etc. However, existing approaches often struggle with generating molecules ... |
41553175 | Preparative Enantiomer Separation of Gossypol as Chloramphenicol Derivative With Cyclodextrin as Chiral Selector by High Speed Countercurrent Chromatography. | This study proposed a general strategy of "pre-column derivatization-chiral selector synergy" and achieved preparation-level separation in the gossypol derivative system for the first time. In this study, gossypol acetate was derived by chloramphenicol base (d-(-)-threo-1-(p-nitrophenyl)-2-amino-1,3-propanediol), and t... |
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