ids
stringlengths
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11.1k
Q6LMF5
MLSQAKNGASIVGEWLTKPPAPCLYDRQLVWITLSLMITGLVIVTSASVPVATRLTGIPFYFALRHAFFLVCSLVIIAGVVQVPLSRWKQFSVPMLFLSIVLLIIVLLIGRSVNGAARWIPLGIFNLQPAEVAKLSLFIFLAGYLVRQYSQVRASFIGFIKPLAVLGVLAFLLLMQPDLGSFVVMFVTTVGMLFIAGAKLWQFLVMISGALLGIGLLIVFEPYRLRRVTSFLDPWEDPFGSGYQLTQSLMAFGRGELMGQGLGNSIQKLEYLPEAHTDFVFAVLGEELGLIGVTVVLLLIFALVFKALFIGRKCLQSGQLFGGFLACGFSFWFAFQTLVNVGAAIGMVPTKGLTLPLISYGGSSLFIMATAVGILLRIDHEQRLFAKYGPAESEELDDSGLNDSNNNDEQE
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44892 Sequence Length: 411 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
Q15Q16
MNTSTFATPLRAMFAQRHDAAPAVVRPYDVSLILLALSLMAIGLVIVTSASMPVASRLFDNPFHFAIRHGIYIVLAIGAALTVMQIPMQWWRTSNAWLLLLGLVLLIAVLLVGRSVNGSTRWLAIGPITIQAAEPAKLFFFCYLAGYLVRRYEEVTENIKGFAKPLVVFFAFAVLLLLQPDLGTVVVMLCTTIGLLFLAGAKLWQFFGLAFTGGAAVTFLIMFEEYRMKRITSFLDPWADPFGSGYQLTQSLMAYGRGDVFGQGLGNSLQKLEYLPEAHTDFIMAILAEELGFAGVLTVLALMLCIVLKAMKMGSKALQNERPFDAYLAYSIGIWFSFQTAVNVGASAGILPTKGLTFPLLSYGGSSLIIMAAAVGLLVRIDFEMRVEGIQAIDRSGKAKASTSSSRKNKPKTASSAGKKKVSTVLDDVAYAVVDDVQDEEQDIDSIMDDFAQDESAQTVSHQTKRASKSTSKTPRGKDEEQEDGYV
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 53074 Sequence Length: 487 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
C3KCS9
MSIDFRNIIKPYPSPIITGRGIDLDFPMLAGCLALLGLGLVMITSASSEVAAVQSGNTLYMMIRHLVYLVIGLGACIVTMMIPIATWQRLGWLMLIGAFGLLIMVILPGIGREVNGSMRWIGFGAFNVQPSEIAKVFVVIYLAGYLVRRQKEVRESWMGFFKPFIVLLPMAGLLLMEPDFGATVVMMGAAAAMLFLGGVGLFRFTLMVVLAVAAVTVLVQAQPYRMARLITFTDPWSDQFGSGYQLTQALIAFGRGEWLGVGLGNSVQKQFYLPEAHTDFVFSVLAEELGVVGSLCTVALFVFVCVRGMYIGMWAEKAKQYFAAYVAYGLSFLWIGQFLINIGVNVGLLPTKGLTLPFLSYGGSSLVICCACLGLLLRIEWESRTHLGSEEMEFSESDFAEEPTHGR
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44552 Sequence Length: 407 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
D4G8R2
MKKSHLYNRSLLSVTIILLIFSIIMVGSSSVSVGNRIRTDYLSFLKKNFIHSIISILCMIFVFNVPIYKWKKNKNKLILCSIILLLTLNYFGISNHGAKRWINIKIAFIQPSELVKISFSCYLSSYLSEKNKKTSTIQLISIILIVSKLLLSQPDFGTLVILYSSLLFMLFLIGKNFLFLSASSAIFTTIVLSLIYFRSYRAKRLISFLNPWSNYLGDGYQLVHSMLSFGRGKMFGQGIGNSIQKINFLPEPHTDFIISIIGEELGYLGIAMIVISLFFIFFQGMNIGRNALKDFQYFSGFLAYSISLLIIIQSIINIGSSIGILPIKGTTLPIISYGGSSKLITCIKIAILLRIDFETKMNKIQAFRR
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 41733 Sequence Length: 369 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
Q21MH0
MIVNIASPLYGSVQGFRRLDFSLYATVAILISVGIVMVASSSLDFAAERYHDTWFFVRKQITFLAMGLVGGLVILAVPMSVWNKYSGLLLILAFFLLMAVLIPGIGKVVNGSRRWLSLGPFSMQASEIAKFCLIVYFASYLARRNEELRTQWSGFLKLTAVLLIIVLLLLLEPDFGSSVVISATLGCMMFVAGVPLARFLLLAVSGVAGLALMAVASPYRWERLVAFMDPWATQFDSGYQLVQSLIAFGRGGWFGVGLGNSLQKLFFLPEAHTDFIFAIFTEEFGFIGAIALIGVFGFFLYRLVILFRRASEQEQFFSSYVVFGIGVMLAMQAFINMGVASGFLPTKGLTLPFISYGGSSLLITCGLMALVFRVNLELNRENQEGKP
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 42562 Sequence Length: 387 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
A8FQ99
MRSEERQLNLFGTSVNWSWPNLFKEREAPGMQLYDRALLFAVLSLICFGFVMVMSASMPEAQSLTGNPYHFAIRHFAYLVGCAVIAAVVLRIEMSRWQQFSPLLLLIVGIMLVAVLLVGTSVNGATRWLSVGPIRIQVAELAKFAFTIYMAGYLVRRHQEIRENAKGFYKPIAVFAVYAFLILMQPDLGTVVVLFVGTVGLLFLAGARLLDFFALILTGVMAFVALVLLEPYRMRRVTSFMDPWQDPFGSGYQLTQSLMAYGRGDWFGQGLGNSIQKLEYLPEAHTDFIFAVIGEELGFIGIVVVLSVLLFVALRAIKLGNLCIEIDKPFEGYLAYAIGIWFCFQTVVNVGASIGMLPTKGLTLPFISYGGSSLWVMTAAAMILIRIDHERRLSSIQAVQGKKVNDNREY
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45693 Sequence Length: 410 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
P74180
MITAANLLRIIFPFYDPEVLRWSGEARLMRTLFFAWMAMGVVVLFSASYAESLDTSGTGLSIILKQIAYLWLGLNIFNFLVRLPLQVCLKLVPWFLIVVLLLIFLTKSGLGVEVNGARRWISLGPILIQPSEFMKPCLVLQAANLFGNWHRFPWRSRLIWLGIFALTLGSILLQPNLSTTALCGMGLWLIALASGLPWIYLISTALLGITTAVTSISIRDYQRARVTSFLDPFADPRGDGYQLVQSLYAIASGGVLGRGFGMSQQKLFYLPIQTTDFIFAVFAEEFGLVGCITFLAFLGLFTTMGLRVAMRCRHRVKRLIGLGVVIFLVGQSLLNIGVASGALPTTGLPLPFFSYGGSSCLSSLVLAGLLVRVARESNEAEVIPLGTKTAPAV
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43038 Sequence Length: 393 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
E8UEF9
MGLIMVFSSSIALGDGPKYVNAGRYYFFSRQLIFILIGLFAMAFTFLMPMKFWDSKAFWGYCICFLLLALVLVPGIGREVNYAYRWIPIGPFNFQPSEFAKLTMIVFTSAYTVRKQKSIHGLKGFLPIIIYLGIICFLLINEPDLGATMVVVAIVMSILLLGGLGFALFSLLFLSAVLLVIAAILTAPWRMQRFFAYLDPFSQEHAQNTGYQLTHSLIAVGRGGFFGEGLGLSIEKLHYLPEAHTDFIMAVVGEELGFVGIFFVILLFVLLVRKGLNVGRQAIAMDRLFNGLVAQGVVVWFGVQAIVNLGVCFGVFPTKGLTLPFISYGGSSIVISLMAFGLLLRVDYENRCLMRGQKPLGIGASYA
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 40512 Sequence Length: 367 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
D5X4H4
MLERMLPFLGRKRDKAAADLPVRVGHSAPRNSRMLEYDQNLVWVTLLLLAYGLVMVYSATISFHDSPRYAQWSPYHYFIRDLFSIAAALLASWIVVQIPMAELQKWSMRFFFLSLIGLVLVLLPHIGKDVNGSKRWVVFPGGLNFQPSELVKLTALIYAADFMVRKQEVKQSLLKTFLPMMAVMMIVGVLLLAEPDMGAFLVIASITLAILFLGGANGKLFSVFSVAVIGAFVLMIVLSPWRRDRIFAYLNPWSESNALGSAYQLSHALIAMGRGEWFGVGLGGSIEKLHYLPEAHTDFLLAIIGEELGLVGVGVVIFAFYWIVRRAFDIGRQALVLDRMYSALVAQGIGVWIGGQAFINIGVNLGLLPTKGLTLPLMSYGGSALLLNCMAIAVLLRVDFENRILMRGGHV
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 45509 Sequence Length: 411 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
D3SD93
MSTGSLPLGLPSRDSLDGLRNSVDLPLLAAAALLLGLGLIMVASASMDLGERYYGNTWHFFQRQVLFAAIGLALATVMWAIPLERWERAGPWLLILVMVLLIAVLLPGVGRTVNGATRWIPIGMFNLQVAEPVKLLVVMYLAGYIVRHYSALRLHLRGFVRPLVVLGFGTVLLLLQPDFGGAAIMLAIGMGMLFLAGAKLWQFAALGATIAVGMAFVAVAAPYRVARLTAFLDPWQDPFATGFQLTQSLIAIGSGGWFGTGLGNSVQKLFYLPEAHNDFLFAVFAEEFGFIGVLALIALFAVVVWRCVKIGLWAERAGHAFGSHLAFGVAIWLALQSALNLAVNMGLLPTKGMTLPFLSYGGSSLIVTLMAIGLVMRVYREAQIPAPRQSTPPRRKRGQA
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 43131 Sequence Length: 400 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
E6UUM7
MNSAAAGATPNTRTSRFGGWFRRARSGIDSLPVHLPVRLGGAGIAQTKATPMRVLGFDQALVWVTVALLTWGLVMVYSASIALPDNPRFARAGYGASFFLTRHAASVAFAFIAALLAFQIPMKTWERAAPWLFVVSLLLLVAVLIPHIGISVNGARRWLPMGFMRFQPSELAKVAMVLYAASYMVRKMEIKERFFRAVLPMGIAVVVVGMLVMAEPDMGAFMVIAVIAMGILFLGGVNARMFFVIAALVVVAFGTIVASSPWRRERIFAYLDPWSEEHALGKGYQLSHSLIAIGRGEIFGVGLGGSVEKLHWLPEAHTDFLLAVIGEEFGLVGVLLIIGLFLWLTRRVMHIGRQAIALDRVFSGLVAQGVGVWLGFQTFINMGVNLGALPTKGLTLPLMSFGGSAILMNMIALAIVLRIDYENRVLMRGGRV
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 46972 Sequence Length: 432 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
Q8D2Z5
MNNKKKIVKIFFYDKILFFLLISLSIIGIIIVSSASISFGIRLHNDYFYFAKRNLLYFFLSFFLFFQIIRIPINQLEKYNKIALLINLFLLIIVFIIGNSINGAIRWIKIGFFSIQPSECSKLILFFYISDYIVKKNKELKNKLWGFLKPIIIMLIFVILLLMQPDLGNSLILFLTTLLLFFLAGINLWKCCFMFLFGLLTIFILIIFKPYRIRRILSFLDPWEDPFNSGYQLTQSLMALGRGKIIGTGLGNSIQKLEYLPEAYTDFIFSILGEELGYIGSIIILIMLFFVIFRIFLIGKNSFIQKKFFSGYFSFSVGIWISLQTIMNVGGVIGILPIKGLTLPFISYGGSSLITIFSAIAIVIRSDFELRINKYQAYLKQ
Function: Peptidoglycan polymerase that is essential for cell division. Catalytic Activity: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+) Location Topology: Multi-pass membrane protein Sequence Mass (Da): 44051 Sequence Length: 381 Pathway: Cell wall biogenesis; peptidoglycan biosynthesis. Subcellular Location: Cell inner membrane EC: 2.4.1.129
Q8P3K2
MRTIIALETHDVRFPTSRELDGSDAMNPDPDYSAAYVVLRTDGAEDLAGYGLVFTIGRGNDVQTAAVAALAEHVVGLSVDKVIADLGAFARRLTNDSQLRWLGPEKGVMHMAIGAVINAAWDLAARAANKPLWRFIAELTPEQLVDTIDFRYLSDALTRDEALAILRDAQPQRAARTATLIEQGYPAYTTSPGWLGYSDEKLVRLAKEAVADGFRTIKLKVGANVQDDIRRCRLARAAIGPDIAMAVDANQRWDVGPAIDWMRQLAEFDIAWIEEPTSPDDVLGHAAIRQGITPVPVSTGEHTQNRVVFKQLLQAGAVDLIQIDAARVGGVNENLAILLLAAKFGVRVFPHAGGVGLCELVQHLAMADFVAITGKMEDRAIEFVDHLHQHFLDPVRIQHGRYLAPEVPGFSAEMHPASIAEFSYPDGRFWVEDLAASKAKA
Cofactor: Binds 1 Mg(2+) ion per subunit. Function: Plays a role in the catabolism of L-fucose. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. L-fuconate is the preferred substrate with 15-fold lower activity observed for L-galactonate and 8-fold lower activity with D-arabinonate. No activity detected with D-fuconate. Can also catalyze the epimerization of L-talonate and D-ribonate, but at slow rates. Catalytic Activity: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O Sequence Mass (Da): 48124 Sequence Length: 441 EC: 4.2.1.68
Q8XNL5
MKTYPKIGIRPTIDGRQGGVRESLEEKAMKMAQAAKKLIENSLYYADGTPVQCVLASRTIGGSGDAGIVQQEFTGKNIVATLSVTPSWCYGTETMDLDPNTIKAIWGFNGTERPGAVYLAAAMSGYAQKGIPAFKIYGHDVQELDDDTIPVDVQEKILSFARGAIAVGQMKGKSYVNIGASSMGIAGSQVDISFFEDYLGMLVEFVDMTEILRRIHLEIFDPIEYDKALNWIKENCREGIDINEGKDLPDIVKKSKVIPADKDWEFIAKQAIIIRDILYRNEKLGDLGWEEEARGRNAIAGGFQGQRQWTDWLPNGDFTEAIMASTFDWNGPRQVTAFATENDTLNGVSMLLGTLLTNKAPIFSDVRTYWSPESVKRVTGKELTGKAKNGIIHLINSGASALDGTAAAKDKDGNKTMKEFWNMTNEDVQSCLKATDWCRANYEYFRGGGFSSHFKTEAELPVTLIRVNLIKGIGPTLQIAEGYTCVIDEDIHQILDERTDKTWPTTWFAPNLGECGFETVYDVMNHWGANHGAFVHGHIGSDLITLASMLRIPVTLHNVPRERIFRPNIFEGAGTKALETADFEICRLLGPLYKK
Function: Converts the aldose L-fucose into the corresponding ketose L-fuculose. Catalytic Activity: L-fucose = L-fuculose Sequence Mass (Da): 65929 Sequence Length: 595 Pathway: Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. Subcellular Location: Cytoplasm EC: 5.3.1.25
Q8ZMC4
MLKTISPLISPTLLKVLAEMGHGDEIIFSDAHFPAHSLGPQVIRADGLSVSDLLRAIIPLFELDSYAPPLVMMAAVEGDTLDPNVEARYRDALSLEAPCPDIVRIDRYAFYERAQKAFAIVITGECAKYGNILLKKGVTP
Function: Involved in the anomeric conversion of L-fucose. Catalytic Activity: alpha-L-fucose = beta-L-fucose Sequence Mass (Da): 15281 Sequence Length: 140 Pathway: Carbohydrate metabolism; L-fucose metabolism. Subcellular Location: Cytoplasm EC: 5.1.3.29
Q8P3K1
MSMQRLCYVLDLHDDAALIAQYERWHRPSEVWPEVVASLQQAGIAELEIFRSGDRLVMLMTVGEDYDPAAKAARDAGDPRIQAWEALMWRFQKALPGSAPGEKWREAGRIFALSEAVSVQQGSAA
Function: Plays a role in the catabolism of L-fucose. Involved in the anomeric conversion of L-fucose. Catalytic Activity: alpha-L-fucose = beta-L-fucose Sequence Mass (Da): 13959 Sequence Length: 125 EC: 5.1.3.29
Q8GW72
MNSQITLFFFFFSILSLSQISNSSSLLKPHPCPILPLPSSQQLQWQLGSMAMFLHFGPNTFTDSEWGTGKANPSIFNPTHLNASQWVQIAKDSGFSRVILTAKHHDGFCLWPSEYTDYSVKSSQWRNGAGDVVAELASAAKEAGIGLGLYLSPWDRHEQCYGKTLEYNEFYLSQMTELLTKYGEIKEVWLDGAKGDGEKDMEYFFDTWFSLIHQLQPKAVIFSDAGPDVRWIGDEAGLAGSTCWSLFNRTNAKIGDTEPSYSQEGDGYGQDWVPAECDVSIRPGWFWHASESPKPAVQLLDIYYNSVGRNCLFLLNVPPNSSGLISEQDIKVLEEFSEMKNSIFSNNLARKAFVNSSSIRGDQSSQFGPKNVLEEGLDKYWAPEENQNEWVLYLEFKDLVSFNVLEIREPIHMGQRIASFHLETRKTGSGEWERVVSGTTVGNKRLLRFLNVVESRSLKLVVDKARTDPLISYLGLYMDKFSGSSRNTTKITITRTLKEEQQLHDL
Function: Hydrolyzes both 3- and 4-linked fucoses in Lewis determinants. Not active on neither 2-linked fucose nor on fucose in alpha-1,3-linkage to the innermost GlcNAc. Catalytic Activity: an alpha-L-fucoside + H2O = an alcohol + L-fucose Sequence Mass (Da): 57186 Sequence Length: 506 Subcellular Location: Secreted EC: 3.2.1.51
Q7XUR3
MATILLLLLGLLVGLPLLRAHGVTGSAAPTPPPLPVLPVPSYAQLQWQLSEMALFLHFGPNTFTDSEWGSVRADPAVFAPSALDAGQWARAAAAGGFGRVVLTAKHHDGFCLWPSALTNYSVAASPWKGGAGDVVGELAAAARAEGIGLGLYLSPWDRHEPVYGDTVAYNEHYLGQMTELLTRYGDVEEVWLDGAKGEGKDMDYMFDAWFALIHQLQQRVVIFSDAGPDTRWVGDEAGVAGYTCWSPFNKSTVTIGHIIPEYSRCGDPFGQDWVPAECDVSIRPGWFWHASEKPKNATTLLDIYYKSVGRNCLLILNVPPNSSGLISTEDMQVLQEFTEIRQTIFSQNFAANATVTASTVRGGLGNQQFAPSNVLQESIYSYWAPEEGQSSWEMLFDLGQSASFNVIQLQEPIQMGQRVIKFRVEILVDELWQTIVEGTTIGYKRLFQFPVVEGQFLKLSIDGARADPLISFFGVFTDSFSVTYSLENHEKPSVVNSSEVIMLRTDHSFGNKSIATM
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Active only against 2'-fucosyl-lactitol when heterologously expressed. Catalytic Activity: an alpha-L-fucoside + H2O = an alcohol + L-fucose Sequence Mass (Da): 56792 Sequence Length: 517 Subcellular Location: Secreted EC: 3.2.1.51
Q8L7W8
MAEKSSFFVHFSCLLLLLTIIITCGEGVRNPVRPRSSERRALMDGQDLSRPLKLTFGGPSRNWTDAIPIGNGRLGATIWGGVSSEILNINEDTIWTGVPADYTNQKAPEALAEVRRLVDERNYAEATSEAVKLSGQPSDVYQIVGDLNLEFDSSHRKYTQASYRRELDLETAVAKVSYSVGAVDFSREFFASNPDQVIIAKIYASKPGSLSFKVSFDSELHHHSETNPKANQILMRGSCRPKRLPVNLKKSINATNIPYDDHKGLQFASILEVRVSNGGSVSSLGGKKLSVEKADWAVLLLAASSNFDGPFTMPVDSKIDPAKECVNRISSVQKYSYSDLYARHLGDYQKLFNRVSLHLSGSSTNETVQQATSTAERVRSFKTDQDPSLVELLFQYGRYLLISSSRPGTQVANLQGIWNRDIQPPWDGAPHLNINLQMNYWHSLPGNIRECQEPLFDYMSALAINGRKTAQVNYGASGWVAHQVSDIWAKTSPDRGEAVWALWPMGGAWLCTHAWEHYTYTMDKEFLKKKGYPLLEGCTSFLLDWLIKGKDGFLQTNPSTSPEHMFTAPIGKPASVSYSSTMDIAIIKEVFADIVSASEILGKTNDTLIGKVIAAQAKLPPTRISKDGSIREWAEDFEDPEVHHRHVSHLFGLFPGHTITVEKSPELAKAVEATLKKRGEEGPGWSTTWKAALWARLHNSEHAYRMVTHIFDLVDPLNERNYEGGLYSNMFTAHPPFQIDANFGFAAAVAEMLVQSTTKDLYLLPALPADKWPNGIVNGLRARGGVTVSIKWMEGNLVEFGLWSEQIVSTRIVYRGISAAAELLPGKVFTFDKDLRCIRTDKL
Function: Hydrolyzes alpha-1,2-linked fucose. Also active on fucosylated xyloglucan oligosaccharides. No activity with 3-fucosyllactose, p-nitrophenyl-alpha-I-fucopyranoside, lacto-N-fucopentaose II, lacto-N-fucopentaose III or alpha 1,6-fucosylated chitopentaose. Involved in apoplastic xyloglucan metabolism. Catalytic Activity: an alpha-L-fucoside + H2O = an alcohol + L-fucose Sequence Mass (Da): 93725 Sequence Length: 843 Subcellular Location: Secreted EC: 3.2.1.51
Q9BTY2
MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Catalytic Activity: an alpha-L-fucoside + H2O = an alcohol + L-fucose Sequence Mass (Da): 54067 Sequence Length: 467 Subcellular Location: Secreted EC: 3.2.1.51
Q10279
MESVDNNSFFSRIRNSNAYRKVKDFVILDHRPGMTMAERMLTNKDLYPVPPSKRLWGPWNFISFWLADAVNINTWMISATAIELGLNWWEAWICVWVGYLICGILVATTGRPGAVYHISFPVLSRSSFGTWGSLWPILNRSVLACVWYGVQAWIGGECVVLMIRSIWPSFSHIPNTMAKSGTETYQWVGFFIFWLLSNIAIWFPVHQIRHLFTFKAIVAPPAAIAFLIWALVKAHGAGPVIHEPTKLGQYEHAWVVINGIVTCIDGFATLIVNNPDFARFATTPGAVHWPQIITVPLAFGVTSLIGVLVSSASKAIYGTTLWDPTQLLASFLDHSNAHGVRAGVFFIAFGLCIAQLGVNIAANSVSAGNDLSALLPTVINVRRGGYIASIIALCMCPWNLLSSNNNFTTYLSSYSVFLSSFAGVIIADYYFVRKGLIRVAPLYSSSSSSPYYFWKGINFRAFASYICGMLINIVGMAGSTGQKVPKVANTMFNLNYFLGITVACLSHIIICKIFPVTECGEKMLSEVPEEADDYLLTLASEDSIDKDSTSEIYIDGLPTEKEVEKDDVLSITSKKLSGCFP
Function: Transport of uracil. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 64177 Sequence Length: 581 Subcellular Location: Membrane
P05316
MPDNLSLHLSGSSKRLNSRQLMESSNETFAPNNVDLEKEYKSSQSNITTEVYEASSFEEKVSSEKPQYSSFWKKIYYEYVVVDKSILGVSILDSFMYNQDLKPVEKERRVWSWYNYCYFWLAECFNINTWQIAATGLQLGLNWWQCWITIWIGYGFVGAFVVLASRVGSAYHLSFPISSRASFGIFFSLWPVINRVVMAIVWYSVQAYIAATPVSLMLKSIFGKDLQDKIPDHFGSPNATTYEFMCFFIFWAASLPFLLVPPHKIRHLFTVKAVLVPFASFGFLIWAIRRAHGRIALGSLTDVQPHGSAFSWAFLRSLMGCMANFSTMVINAPDFSRFSKNPNSALWSQLVCIPFLFSITCLIGILVTAAGYEIYGINYWSPLDVLEKFLQTTYNKGTRAGVFLISFVFAVAQLGTNISANSLSCGTDMSAIFPKFINIKRGSLFCAAMALCICPWNLMATSSKFTMALSAYAIFLSSIAGVVCSDYFVVRRGYIKLTHIYSHQKGSFYMYGNRFGINWRALAAYLCGVAPCLPGFIAEVGAPAIKVSDGAMKLYYLSYWVGYGLSFSSYTALCYFFPVPGCPVNNIIKDKGWFQRWANVDDFEEEWKDTIERDDLVDDNISVYEHEHEKTFI
Function: Transport of uracil. PTM: Glycosylated (possible); but there is not yet direct biochemical evidence for it. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 71736 Sequence Length: 633 Subcellular Location: Membrane
Q2L6E3
MPGTDDVAVDVASVYSAIEKSAGLLDVTAAREVVWPVLTAFEDVLEQAVIAFRVATNARHEGDFDVRFTVPEEVDPYAVALSRSLIAKTDHPVGSLLSDIQQLCSVDTYGVDLGVKSGFKKVWVYFPAGEHETLARLTGLTSMPGSLAGNVDFFTRYGLADKVDVIGIDYRSRTMNVYFAAPSECFERETVLAMHRDIGLPSPSEQMFKFCENSFGLYTTLNWDTMEIERISYGVKTENPMTFFARLGTKVEHFVKNVPYGVDTQKMVYAAVTSSGEEYYKLQSYYRWRSVSRLNAAYIAARDKEST
Function: Involved in the biosynthesis of furaquinocin. Catalyzes the transfer of a geranyl group to 2-methoxy-3-methyl-flaviolin to yield 6-prenyl-2-methoxy-3-methyl-flaviolin and 7-O-geranyl-2-methoxy-3-methyl-flaviolin in a 10:1 ratio. Can also use other substrates such as flaviolin or 1,3-dihydroxy naphthalene, and can also use DMAPP as prenyl donor. Catalytic Activity: (2E)-geranyl diphosphate + 2-O,3-dimethylflaviolin = 6-linalyl-2-O,3-dimethylflaviolin + diphosphate Sequence Mass (Da): 34248 Sequence Length: 307 EC: 2.5.1.124
Q75W17
MATITTLASSVPLFRPYSFPGGSSRKPKKDNLSIKPPATSSLKVNAKLASADDTSSNFNKDNWLASADELSRSFPPGFLFGGGSASYQYEGAVKEGGRTPSIWDTFAHEFPDKIADGSNGDVAVDFYHRYKDDVKLMKKIGVNGFRFSISWTRILPSGKLCGGVNKEGVAFYNSLINELLANGIEPFVTIFHWDLPQGLENEYDGFLSGQIVNDYRDYAEVCFQEFGDRVKFWTTLNEPWTFCYNGYVNGSFAPGRCSTCTAGNSGTEPYLVAHNLLLSHAAVAQLYKNKYQASQKGQIGIVLVCFWMVPYSDCPYDCEAAQRALDFMLGWFLHPLTYGDYPESMRHLVGERLPQFTEMQAMMMKGSIDFLGLNYYTSIYAANNESPNPHDISYTTDSRVNLFQKRDGILIGPATGTPAFCFCPEGIRDLLVYTKEKYNNPIIYITECGLAEANINTVDQGVKDVERVEFYYEHLKFLRSAIKKGVNVKGFFTWSLLDDWEWNSGFNVRFGIVYIDHEDGLKRYLKYSALWFKKLFGK
Function: Disaccharide-specific acuminosidase, hydrolyzes the beta-glycosidic bond between p-allylphenol and acuminose with retention of anomeric configuration. Has highest activity towards furcatin, and lower activity towards beta-primeverosides and beta-vicianoside. Has very low activity towards beta-gentobiosides. Catalytic Activity: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose. Sequence Mass (Da): 60626 Sequence Length: 538 Subcellular Location: Plastid EC: 3.2.1.161
P09958
MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL
Cofactor: Binds 3 calcium ions per subunit. Function: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif . Mediates processing of TGFB1, an essential step in TGF-beta-1 activation . Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) . By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity). Catalytic Activity: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors. PTM: The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 86678 Sequence Length: 794 Domain: Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface. Subcellular Location: Golgi apparatus EC: 3.4.21.75
P61154
MVKVVRNVVCPFCGTLCDDLEILVEDNHIVGTRHACRIGNAKFMHFEGAVRYTEPLMRENKKDDFKKVDYETAIEETARLLTEATLPLIYGWSATECHAHMYGVELAELVGAVIDNTASVUHGPSLLAVQDVGYPVCTLGEVKNRADVIIFWGSNPMHAHPRHMSRYSVFARGFFRERGREDRTLIVVDPRETDTAKLADIHLQVEPHKDYELVSAMRAVLKGFELQVDKVAGVPADLIYEAVEVCKNAQFGELFFAMGVTMTRGKHRNIDNAIQLVIDLNAYTKFGLMPMRGHYNVNGFNQVLTWVTGYPFGVDFSRGYPRYNPGETTANDLLQRGETDMMLNIASDPGAHFPQKAVQHMAKIPLVCIDPHETPTTQLANIIIPPAIAGVEVEGTAYRMDGVPIQLRKVIDPPEGVLPDREILKILIKKVKEML
Function: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. Catalytic Activity: H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 48718 Sequence Length: 435 Pathway: One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3. EC: 1.2.7.12
Q58571
MKELILTLQKEIIVPVEMDKVLPEVIENMSLEEIKNIELVQGRKRIKVADIFDVELNDIEGEPRIVIKNSSPKLKYIGSKMTKGEIVVEGDAGMYVGAEMKGGKIVVNGNAESWAGQNMKGGELLIKGNAGDYVGSAYRGDWRGMSGGTIIVEGNAGNEIGEFMSKGLIHIKGNVGIMAGIHQNGGIIIIDGDVDVRVGGEMKAGAIVVYGKVEEILPSFKFEGIVENPVIKLSKKDAGTPIAGTFYKFSGDYVYNKPKGQLYISVDSNPDLI
Function: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. Catalytic Activity: H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 29461 Sequence Length: 273 Pathway: One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3. EC: 1.2.7.12
O27600
MSEIILTPKEQPEVPLEAPNIKPDVFAGKSIDEIRNIQIMHGNEVVKLGDFFEVSGEPADSAADIKIIIDGDVYNTKRIGQDMTAGEILVKGNVNMYVGAGMKGGKITVEGNAKSWAGQDMRGGELEIFGDAGDYVGSSYRGDWRGMSGGVITVHGNAGNEIGEYMNGGKIIIKGDVNIMPGIHMNNGLIIIEGNAVARVGGEMAGGTIVVKGMIEEFLPGFKYLGVEKDIEVNGETFPGAYYKFEGDHAIKGAKGMVYAAVGCNGHIEP
Function: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). Can only oxidize formylmethanofuran. This enzyme is oxygen-labile. Catalytic Activity: H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 28641 Sequence Length: 270 Pathway: One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3. EC: 1.2.7.12
Q49611
MVKIVIHEERCHGCGNCVIACPVNACNSPNVWGGKGPEDGEDVVIKVVNGTVSVINEDLCEACMTCELACPVDAIEIKT
Cofactor: Binds 2 [4Fe-4S] clusters. Function: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile. May function as an electron transfer protein. Catalytic Activity: H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin] Sequence Mass (Da): 8345 Sequence Length: 79 Pathway: One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3. EC: 1.2.7.12
P0DM17
MQRGAVLLGVVALLVLWPQAGAELYDVNDPDVRAMVIDGQKLMHDCAIANDYIDDPWWTLNLGAFEEKRVYHSMLSELVFCLNAFLQRRQQAP
PTM: Contains 4 disulfide bonds. Sequence Mass (Da): 10575 Sequence Length: 93 Domain: The cysteine framework is C-C. Subcellular Location: Secreted
P37147
MRWLPFIAIFLYVYIEISIFIQVAHVLGVLLTLVLVIFTSVIGMSLVRNQGFKNFVLMQQKMAAGENPAAEMIKSVSLIIAGLLLLLPGFFTDFLGLLLLLPPVQKHLTVKLMPHLRFSRMPGGGFSAGTGGGNTFDGEYQRKDDERDRLDHKDDRQD
Function: Overexpression alleviates the exclusion of phage T7 in cells harboring the F plasmid. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 17692 Sequence Length: 158 Subcellular Location: Cell inner membrane
C0HJJ0
MSQLTELVLLTVFLALFSRAEANPFVYNYEALRIGGLVFTCVLVAGAVTALCWGQCKPKRKHDDDASKI
Function: May modulate the activity of a sodium/potassium-transporting ATPase. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 7604 Sequence Length: 69 Subcellular Location: Cell membrane
Q14802
MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell . Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 . Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes . PTM: Glutathionylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 9263 Sequence Length: 87 Subcellular Location: Cell membrane
Q61835
MQEVVLSLLVLLAGLPTLDANDPENKNDPFYYDWYSLRVGGLICAGILCALGIIVLMSGKCKCKFRQKPSHRPGEGPPLITPGSAHNC
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell . Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity). PTM: Glutathionylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 9526 Sequence Length: 88 Subcellular Location: Cell membrane
P59645
MQEFALSLLVLLAGLPTLDANDPEDKDSPFYYDWHSLRVGGLICAGILCALGIIVLMSGKCKCKFSQKPSHRPGDGPPLITPGSAHNC
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. PTM: Glutathionylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 9411 Sequence Length: 88 Subcellular Location: Cell membrane
Q63113
MEGITCAFLLVLAGLPVLEANGPVDKGSPFYYDWESLQLGGMIFGGLLCIAGIAMALSGKCKCRRNHTPSSLPEKVTPLITPGSAST
Function: Induces a potassium channel when expressed in Xenopus oocytes. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 9084 Sequence Length: 87 Subcellular Location: Membrane
Q96DB9
MSPSGRLCLLTIVGLILPTRGQTLKDTTSSSSADSTIMDIQVPTRAPDAVYTELQPTSPTPTWPADETPQPQTQTQQLEGTDGPLVTDPETHKSTKAAHPTDDTTTLSERPSPSTDVQTDPQTLKPSGFHEDDPFFYDEHTLRKRGLLVAAVLFITGIIILTSGKCRQLSRLCRNRCR
Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. PTM: Glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 19472 Sequence Length: 178 Subcellular Location: Membrane
P97808
MSLSSRLCLLTIVALILPSRGQTPKKPTSIFTADQTSATTRDNVPDPDQTSPGVQTTPLIWTREEATGSQTAAQTETQQLTKMATSNPVSDPGPHTSSKKGTPAVSRIEPLSPSKNFMPPSYIEHPLDSNENNPFYYDDTTLRKRGLLVAAVLFITGIIILTSGKCRQLSQFCLNRHR
Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity). PTM: Glycosylated. Location Topology: Single-pass type I membrane protein Sequence Mass (Da): 19454 Sequence Length: 178 Subcellular Location: Membrane
B1L7K1
MTRAVAEDLASSLEPDYRILHVLTTGGLEDLMDAIKTARKSEVDLLIGVGGGKPLDITKILAAELGVRYVVVPTSASHDGIASPSVSFTLSREIEERFGRVIRVEAPTAILADTTIINRASPITFKSGFGDLVAKITAVRDWELAYKLRDEPYSEYAASMSLLSAKIAMDHAHEIRTRLEESTRILVKALIGSGVAMSIAGSSRPASGSEHMFSHALDILSSEAGVKPAPHGIQVAIGTIMMAYLQGQDWKMIKEKLIEAGVPTTAEEAGISPDMIVKALTIAHKIRERYTILGSSGLTLSAAEKLARVTGVIK
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Catalytic Activity: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 33618 Sequence Length: 314 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.261
Q2FPC7
MSTDPVQVLQPDGFNKSRWTQLPRDVLIGHQAIMQLPDIIADIKPGRSVLLISGGTTREVAGNTVADILKDQYEVRRFVAGKLDADTLEACSQASSSADFLIGVGGGRVIDCAKIVSYKQGKPFISVPTAASHDGIISGRATLPTETGSVSVGAHPPIAVVADTGIISQAPHRLMASGCADVISNYTAILDWELAHRLRGEQISEYAIALSKMTAEILVKDANLIKPGQEEAAWIVVKALVSSGVSMAIAGSSRPASGGEHKFGHALERLMPGAALHGEACGIGSIMTMYLHGGDWREIRSSLARIGAPTTPRELNIPDEVIVEALMKARDIRPERFTILDMGLTRESAEHLVQMLYEE
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Catalytic Activity: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 38362 Sequence Length: 359 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.261
Q58122
MIIVTPRYTIIEDGAINKIEEILKKLNLKNPLVITGKNTKKYCRFFYDIVYYDEILNNLEIELKKYTAYDCVIGIGGGRSIDTGKYLAYKLGIPFISVPTTASNDGIASPIVSIRQPSFMVDAPIAIIADTEIIKKSPRRLLSAGMGDIVSNITAVLDWKLAYKEKGEKYSESSAIFSKTIAKELISYVLNSDLSEYHNKLVKALVGSGIAIAIANSSRPASGSEHLFSHALDKLKEEYNLNINSLHGEQCGIGTIMMSYLHEKENKKLSGLHEKIKMSLKKVDAPTTAKELGFDEDIIIEALTMAHKIRNRWTILRDGLSREEARKLAEETGVI
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Catalytic Activity: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 37275 Sequence Length: 335 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.261
Q8TW08
MSVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEEAGYQTSPVIVKGSTGDDVKKALEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVPTSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIREAPERLIRAGVGDVVSNVTAVKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMSIAGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGAPTTAEDLGVSDEEIIEALCRAHKIRPDRYTILGDKGLTREAAERAAEETGVIQ
Cofactor: Binds 1 zinc ion per subunit. Function: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Catalytic Activity: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH Sequence Mass (Da): 37642 Sequence Length: 353 Pathway: Membrane lipid metabolism; glycerophospholipid metabolism. Subcellular Location: Cytoplasm EC: 1.1.1.261
Q5HF86
MSTNIAINGMGRIGRMVLRIALQNKNLNVVAINASYPPETIAHLINYDTTHGKYNLKVEPIENGLQVGDHKIKLVADRNPENLPWKELDIDIAIDATGKFNHGDKAIAHIKAGAKKVLLTGPSKGGHVQMVVKGVNDNQLDIEAFDIFSNASCTTNCIGPVAKVLNNQFGIVNGLMTTVHAITNDQKNIDNPHKDLRRARSCNESIIPTSTGAAKALKEVLPELEGKLHGMALRVPTKNVSLVDLVVDLEKEVTAEEVNQAFENAGLEGIIEVEHQPLVSVDFNTNPNSAIIDAKSTMVMSGNKVKVIAWYDNEWGYSNRVVDVAEQIGALLTSKETVSAS
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Catalytic Activity: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH Sequence Mass (Da): 36979 Sequence Length: 341 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.12
Q8CNY0
MATNIAINGMGRIGRMVLRIALNNKNLNVKAINASYPPETIAHLLNYDTTHGVYDKKVEPIESGIKVNGHEIKLLSDRNPENLPWNEMDIDVVIEATGKFNHGDKAVAHINAGAKKVLLTGPSKGGDVQMIVKGVNDNQLDIDTYDIFSNASCTTNCIGPVAKVLNDKFGIINGLMTTVHAITNDQKNIDNPHKDLRRARSCNESIIPTSTGAAKALKEVLPEVEGKLHGMALRVPTKNVSLVDLVVDLEQNVTVTQVNDAFKNADLSGVLDVEEAPLVSVDFNTNPHSAIIDSQSTMVMGQNKVKVIAWYDNEWGYSNRVVEVAVKIGQLIDDKAMVKAI
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Catalytic Activity: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH Sequence Mass (Da): 37092 Sequence Length: 341 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.12
Q829W3
MTIRVGINGFGRIGRNYFRALLEQGADIEIVAVNDLGDTATTAHLLKYDTILGRLKAEVTHTADTITVDGKTIKVFSERNPADIPWGELNVDIVIESTGIFTKKADAEKHIAGGAKKVLISAPASDEDITIVLGVNEDKYDPAKHNVISNASCTTNCVAPMAKVLDENFGIVKGLMTTIHAYTNDQRILDFPHKDLRRARAAAENIIPTTTGAAKATALVLPQLKGKMDGISMRVPVPTGSATDLVVEVSREVTKDEVNAAFKKAAEGELQGYLSYTEDPIVSSDIVGDPSSCTFDSAMTMVMEGTSVKILGWYDNEWGYSNRLVDLTVFVGNQL
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Catalytic Activity: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH Sequence Mass (Da): 36162 Sequence Length: 335 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.12
P00358
MVRVAINGFGRIGRLVMRIALQRKNVEVVALNDPFISNDYSAYMFKYDSTHGRYAGEVSHDDKHIIVDGHKIATFQERDPANLPWASLNIDIAIDSTGVFKELDTAQKHIDAGAKKVVITAPSSTAPMFVMGVNEEKYTSDLKIVSNASCTTNCLAPLAKVINDAFGIEEGLMTTVHSMTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLNKETTYDEIKKVVKAAAEGKLKGVLGYTEDAVVSSDFLGDSNSSIFDAAAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHVAKA
Catalytic Activity: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH Sequence Mass (Da): 35847 Sequence Length: 332 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.12
Q2NEN0
MKSIGINGYGTIGKRVADAVSAQDDMKIVGVTKRTPDYEAKAAVEKGYDLYISVPERESQFEEAGIEVAGTADELFEKLDLVVDCTPGGIGAQNKTDIYEKIGLKAIFEGGEDHDAIGSSFNAEANYADNIGEDYVRVVSCNTTGLCRTLKPIYDISGIKKVRAVMVRRGADPSDVKKGPINSIVPTTEVPSHHGPDVQTIIDDINVMTMALLVPTTLMHTHNIMVELEDKITTDDVLDAFENAHRVLPVQKSLKLGSTAEIMEYAKDLGRSRGDMYEIPVWKESVNIENGELFYMQAVHQESDVVPENVDAIRAMLELEEDGEKSILKTNKAMGIL
Catalytic Activity: D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH Sequence Mass (Da): 36910 Sequence Length: 337 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.59
P47543
MAAKNRTIKVAINGFGRIGRLVFRSLLSKANVEVVAINDLTQPEVLAHLLKYDSAHGELKRKITVKQNILQIDRKKVYVFSEKDPQNLPWDEHDIDVVIESTGRFVSEEGASLHLKAGAKRVIISAPAKEKTIRTVVYNVNHKTISSDDKIISAASCTTNCLAPLVHVLEKNFGIVYGTMLTVHAYTADQRLQDAPHNDLRRARAAAVNIVPTTTGAAKAIGLVVPEANGKLNGMSLRVPVLTGSIVELSVVLEKSPSVEQVNQAMKRFASASFKYCEDPIVSSDVVSSEYGSIFDSKLTNIVEVDGMKLYKVYAWYDNESSYVHQLVRVVSYCAKL
Function: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Catalytic Activity: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH Sequence Mass (Da): 37098 Sequence Length: 337 Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. Subcellular Location: Cytoplasm EC: 1.2.1.12
Q43727
MATHSMIIPSPSSSSSSLATAASPFKETLPLFSRSLTFPRKSLFSQVRLRFFAEKHSQLDTSNGCATNFASLQDSGDQLTEEHVTKGESTLSITVVGASGDLAKKKIFPALFALFYEGCLPQDFSVFGYARTKLTHEELRDMISSTLTCRIDQREKCGDKMEQFLKRCFYHSGQYNSEEDFAELNKKLKEKEAGKISNRLYYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDQYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRSEKVKVLRSMKPLRLEDVVVGQYKGHNKGGKTYPGYTDDPTVPNHSLTPTFAAAAMFINNARWDGVPFLMKAGKALHTRGAEIRVQFRHVPGNLYKKSFATNLDNATNELVIRVQPDEGIYLRINNKVPGLGMRLDRSDLNLLYRSRYPREIPDAYERLLLDAIEGERRLFIRSDELDAAWDLFTPALKELEEKKIIPELYPYGSRGPVGAHYLASKYNVRWGDLGEA
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis . The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division . Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 65428 Sequence Length: 576 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Plastid EC: 1.1.1.49
P9WN70
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRSGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
Function: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 52189 Sequence Length: 466 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. EC: 1.1.1.49
Q9FY99
MAALSSSVTTRSYHSGYLASFSPVNGDRHRSLSFLSASPQGLNPLDLCVRFQRKSGRASVFMQDGAIVTNSNSSESKTSLKGLKDEVLSALSQEAAKVGVESDGQSQSTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYSRSKMTDVELRNMVSKTLTCRIDKRANCGEKMEEFLKRCFYHSGQYDSQEHFTELDKKLKEHEAGRISNRLFYLSIPPNIFVDAVKCASTSASSVNGWTRVIVEKPFGRDSETSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIRVEDVVIGQYKSHTKGGVTYPAYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALHTRSAEIRVQFRHVPGNLYNRNTGSDLDQATNELVIRVQPDEAIYLKINNKVPGLGMRLDRSNLNLLYSARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWSLFTPLLKEIEEKKRIPEYYPYGSRGPVGAHYLAAKHKVQWGDVSIDQ
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis . The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division . Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 67160 Sequence Length: 596 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Plastid EC: 1.1.1.49
P0A585
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
Function: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 57343 Sequence Length: 514 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. EC: 1.1.1.49
O59812
MLSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPGTYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFDYKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCALQLRSEAPRWKGIPIIISAGKGLDRDYFEARITFKRREGGMFPTVDSSNVLVLRVYPKEFIALKGHIKQPGFSRQIVPVTLDVKYPEAFPDTWIHKAYEVVIADAINGKHTHFISDDEVRTSWKIFDDVLDTTGDLSPLPYAFGSHHGPDATLEFFKKRNLEWD
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 53510 Sequence Length: 475 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Cytoplasm EC: 1.1.1.49
Q8L743
MSSLSCPTYRSRTSSSSPFLSNHHHSSLINVVDPRRSLSFHYASPQGLNLAELCVVRSQRRSVQSSVVVQDGSVATESSSSEEAKDVGVLTIPSLEADKVVAESDGGEQLSTVSITVVGASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRVMVSKTLTCRIDKRANCGEKMEEFLKRCFYHSGQYDSQEHFVALDEKLKEHEGGRLSNRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSKTSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIKLEDVVIGQYKSHSIGGVTYPSYTDDKTVPKGSLTPTFAAAALFIDNARWDGVPFLMKAGKALNTRSAEIRVQFRHVPGNLYNRNSGTDRDQTTNELVIRVQPDEAIYLKINNKVPGLGMRLDQSNLNLLYSARYSKEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKEIEEKKTTPEFYPYGSRGPVGAHYLAAKHKVQWGDLSLDQ
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis . The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division . Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 67358 Sequence Length: 599 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Plastid EC: 1.1.1.49
O14137
MVTFMVFGASGNLANKKTFPALFHLFKRNLVDRSSFYVLGYARSKIPIGEFRESIRESVKPDTESKQVFQDFIDRVSYFSGQYDQSSSYVEFRKHLESVEKKADSSKALRIFYIALPPSVYVTVSSHIYENLYLPGKSRLVIEKPFGKNYQSAVKLKEEVHKHWKEEEIYRIDHYTAKDMVNNFFTLRFANSSSIDAVLNRHSIQSVEIHMYETGGCEGRIGYYDANGVVRDVVQNHLTQIFCIAAMNEPKSASASDVRAEKVNLLKATRPASLKESMLGQYTTSEDGKIPGYLDLEGVPKDSKATTFAASTLHVDNDRWKGVPFVFVSGKRMKKGEVYIKYYFRLKDSGIFSDVKRRRYLILHVQPEEFVNLTCTINKPMTTDLQPIDAYASLNYNEQFKDLMKEKRDGYEILFEDAIRGDPTKFIRYDEVEYAWKIWDEILDSPKKPIPYPAGSDGPEGLEAYMKRHLGHE
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity). Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 54430 Sequence Length: 473 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Cytoplasm EC: 1.1.1.49
Q9LK23
MGSGQWHMEKRSTLKNDSFVKEYNPVTETGSLSIIVLGASGDLAKKKTFPALFNLFHQGFLNPDEVHIFGYARSKITDEELRDKIRGYLVDEKNASKKTEALSKFLKLIKYVSGPYDSEEGFKRLDKAILEHEISKKTAEGSSRRLFYLALPPSVYPPVSKMIKAWCTNKSDLGGWTRIVVEKPFGKDLESAEQLSSQIGALFEEPQIYRIDHYLGKELVQNMLVLRFANRLFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQVLCLVAMEKPISLKPEHIRDEKVKVLQSVIPIKDEEVVLGQYEGYRDDPTVPNDSNTPTFATTILRINNERWEGVPFILKAGKAMSSKKADIRIQFKDVPGDIFKCQNQGRNEFVIRLQPSEAMYMKLTVKQPGLEMQTVQSELDLSYKQRYQDVSIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDKGEVKSVPYKQGSRGPAEADQLLKKAGYMQTHGYIWIPPTL
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis . The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division . Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 59157 Sequence Length: 516 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Cytoplasm EC: 1.1.1.49
Q9FJI5
MGSGQWHVEKRSTFRNDSFVREYGIVPETGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLNPDEVHIFGYARTKISDEELRDRIRGYLVDEKNAEQAEALSKFLQLIKYVSGPYDAEEGFQRLDKAISEHEISKNSTEGSSRRLFYLALPPSVYPSVCKMIKTCCMNKSDLGGWTRIVVEKPFGKDLESAEQLSSQIGELFDESQIYRIDHYLGKELVQNMLVLRFANRFFLPLWNRDNIENVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQVLCLVAMEKPISLKPEHIRDEKVKVLQSVVPISDDEVVLGQYEGYRDDDTVPNDSNTPTFATTILRIHNERWEGVPFILKAGKALNSRKAEIRIQFKDVPGDIFRCQKQGRNEFVIRLQPSEAMYMKLTVKQPGLDMNTVQSELDLSYGQRYQGVAIPEAYERLILDTIKGDQQHFVRRDELKVAWEIFTPLLHRIDKGEVKSIPYKPGSRGPKEADQLLEKAGYLQTHGYIWIPPTL
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis . The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division . Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 59116 Sequence Length: 515 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Cytoplasm EC: 1.1.1.49
Q43839
MGVQLRLNPCSSSSAATSPSTFHNGTPYFCKKFNFLPFRTQPLNWVSGIYSRIQPRKHFEVFSSNGFPLNAVSVQDVQVPLTELGSGDTTVSITVIGASGDLAKKKILPALFALFYEDCLPENFVVFGYSRTKLSDEELRNMISTTLTCRIDKRENCDAKMEHFLERCFYHSGQYNSEDDFAELDYKLKEKEGCRVSNRLFYLSIPPNIFVDVVRCASLKASSTSGWTRVIVEKPFGRDLESSSELTRSLKKYLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQFIFSEDFGTEGRGGYFDHYGIIRDIMQNHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPLQLEDVVLGQYKGHSNGAKSYPAYTDDPTVPNGSITPTFSAAALFIDNARWDGVPFLMKAGKALHTKRAEIRVQFRHVPGNLYKRNFGTDMDKATNELVLRLQPDEAIYLKINNKVPGLGMRLDRSDLNLLYKAKYRGEIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIAPELYPYGSRGPVGAHYLAAKHNVRWGDLSGDD
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division. Catalytic Activity: D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH Sequence Mass (Da): 65687 Sequence Length: 577 Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Subcellular Location: Plastid EC: 1.1.1.49
B5EBB8
MQKQQLWERYKNLLYHDAELELSVDTSRIDFPEGFLEKMDPRLQQAYQEMEALEQGAVANPDEHRMVGHYWLRAPELAPEATLAEEITSTLAAIEAFASSVHGGNIAAPDGHRFTDLLIIGIGGSALGPQFLADSLGGPKDLLRIWFFDNTDPDGMDKVLSGIGAALKQTLVVVISKSGGTKETRNGMLEACQAFERAGLHFAGHAVAVTGSGSELDRTASRENWLGVFPMWDWVGGRTSVTSAVGLLPAALQGIDVDRLLAGARACDQKTRSRVTRENPAALLALSWFHATQGKGTRDMVLLPYKDRLLLFSRYLQQLIMESLGKGLDRDGKEVLQGIAVYGNKGSTDQHAYVQQLREGVHNFFVTFIEVLKDRQGPSMEVEPGATSGDYLSGFFQGTRSALYEKGRESVTITVRELSPASIGALIALYERAVGLYASLVNVNAYHQPGVEAGKEAAGAVLKLQGEIMELLRRQPNRDFTGEEMALALARPEEVETTFMILRHLAANGDHGVSVTEKDKIWENKYRSKD
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 58161 Sequence Length: 530 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q8FR39
MANDITTTAAWQSLTERYEAFQGTTLRELFQDGGRAEKLSFDAAGLRVDLSKNLLDDAILTDLVALAEQAGLTDRIEAMFRGEHINNTEDRAVLHTALRLPVEESLEVDGQDVAADVHEVLGRMRDFATALRSGAWLGYTGRTIKKVVNIGIGGSDLGPAMATKALRAYATAGITAEFVSNVDPADMVSVLEDLDAESTLFVIASKTFTTQETLANANAAKNWLIEQLGSEEAVSKHFVAVSTNAEKVTAFGINPENMFGFWDWVGGRYSVDSAVGLSLMAVIGPRDFMRFLGGFRAMDEHFRYTDFGQNVPVLMALLSVWYTDFFGAETHAVLPYSEDLSRFAAYLQQLTMESNGKSVRRDGSPVTTGTGEIYWGEPGTNGQHAFFQLIHQGTRLIPADFIGFARPKQDLPAGEKSMHDLLMSNFFAQTKVLAFGKTAEEIAAEGVDDNLINHKVMPGNRPTTTILAEELTPAVLGALIALYEHIVFVQGVIWDINSFDQWGVELGKQQASDLAPAVSGEVEVDSGDSSTDALIRWYRTNR
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 59230 Sequence Length: 542 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q4A5S9
MSSSYLKLDFKLKNQVVPFESYQKQVSQIHNAVKSKSVEEKDWLGWLNLASDYNKEEYAKMEEKVAQWLKDKVEVVVVIGIGGSYLGAKTGYEFIFGKYSIKKPQMELVFAGNDISAETLVAKLNYVKDKKFAINVISKSGTTLEPSIAFREFRNLLEQKEVNSWEYIVATTDKQKGVLFELATAKKYTKFVIPDDVGGRFSVLTAVGLFPFLCAGIDAKKVLEGARQMNKELFSENVMENAAYKYAVARHYLHKEKKYAVEIFVSYEPKLRYFAEWWKQLFAESEGKDGKGLWPSSAIFSTDLHSLGQMIQDGPKILFETVLTLENPAYDITFKDNVIDYDKLNYLSDKKLSEVNNVAFNATMEAHSDEGNVPNISMLFKDFSEETLGALFMFFMRAVTMSAYLLGVNPFNQPGVEVYKKNMFFLLGKK
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 48990 Sequence Length: 430 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
A1TEQ0
MGSDITATPAWQALSRHHDEIRAKDLRGLFADDPTRGTGFALTVGDLYIDYSKHRVTRETLDLLLDLARTAGLPAKRDAMFSGAHINTSEDRAVLHTALRLPRDASLTVDGQDVVADVHEVLDRMGDFTDRLRSGEWRGATGERITTVVNIGIGGSDLGPVMVDQALRHYADAGISARFVSNVDPADLVAKLNGLDPATTLFIIASKTFSTLETLTNATAARRWLVDGLGGSAGQDAVSKHFVAVSTNAKLVDDFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAVIGRERFAEFLAGFHLVDEHFRSAPLEANAPVLLGLIGLWYSNFFGAETRAVLPYSNDLARFAAYLQQLTMESNGKSVRADGTPVSTGTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFSEPTDDLPTADGTGSMHDLLMSNFFAQTQVLAFGKTAEEITGEGTPPNVVPHKVMPGNRPSTSILATKLTPSVVGQLIALYEHQVFVEGVIWGIDSFDQWGVELGKTQAKALLPVLTGADSPAAQSDSSTDALVRRYRTERGRTA
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 59595 Sequence Length: 553 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q1CX51
MTERELWERYQRYLCVVPALDFTLDVSRMRFPADYLERMRPRLEEAFGAMEALEKGAVANPDEKRKVGHYWLRAPELAPEPALQKEITDTVAAIHAFAKNVHEGRVKPQKAQRFTHMLIVGIGGSALGPQLVADALGTAKDPMQVSFFDNTDPDGFDRVLAQLGERLSETLTLVISKSGGTKETRNGMLEAERGYSARGLDFSKHAVAVTGAGSELDNHAKKQGWLRAFPMWDWVGGRTSVTSAVGLLPARLQGLDIDALLKGARDMDAATRERDALKNPAALLALMWHYAGDGRGHKDMVILPYKDRLLLMSRYLQQLVMESLGKETDLDGQVVNQGIAVYGNKGSTDQHAYVQQLREGVLNFFATFIEVLKDRDGGSQEVEPGVTSGDYLLGFLLGTRRALYEKDRESLTLTVPDVSARTLGALIALYERAVGFYATLVHINAYHQPGVEAGKKAAGVVLELQRKLTTRLREARAEARTAEQLAADIGMPDEVETVFKVLQHLAANPDRGVTRTPGATPTQARFQAK
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 58323 Sequence Length: 529 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q2YBU4
MITPLTQRPAWKALEAHYQTIKGMHLRQLFADDPKRGERFTAEAVGLYLDYSKNRITDETLHLLVQLAEECGLRERIEAMFRGDAINVTEQRAVLHIALRAPRNEKILVDGNDVVPGVHAVLDRMADFSDKIRSGDWQGHTGKRIRNIINIGIGGSDLGPVMAYEALRHYSLHNLSFRFISNVDGTDFVEATRGLDPEETLFIICSKTFTTTETLANAHTARRWMLRQIKDLEGVRKHFVAVSTNAEEVARFGIDTANMFEFWDWVGGRYSMDSAIGLSTMIAVGPENFREMLAGFHAMDQHFYSAPFDRNLPVLMGLLSLWYNNFFGAQTLAVLPYEQYLKRFPAYLQQLTMESNGKHITLNGSQVDYQTSPIVWGEPGTNGQHSFYQLIHQGTRLIPCDFIGFCQTLNPLGDHHDLLMANLFAQTEALAFGKTEDEVKAEGVPDWLCPHRSFEGNRPTNTILAERLTPHTLGALVALYEQSVFTQGTIWQIDSFDQWGVELGKVLAHRIGQELEDENGKSLKHDSSTNALIQRYNRLKQK
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 61372 Sequence Length: 542 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q3JCN1
MKPYLAQARSWASLLQHYGCIKKQHMRDLFAADPQRFDKFSLIFNGILFDFSKNRITEETLKLLLDLARERELQQGISRMFAGEPINNTENRPVLHVALRNRANRPIMVKGKDVMPQVNVVLERMGKFCDRVHRGQWRGFSGERLTDIVNIGIGGSDLGPAMVTEALQPYAKSGFRVHFVSNIDGTQLAETLKTIRPETALFVISSKTFTTQETLTNAHSARNWFLRAAPDDKAIAKHFIAVSTNRSEVEKFGIDPCNMFEFWDWVGGRYSLWSAIGLSIALYLGMENFEQLLEGAHEMDKHFQETPLKQNIPVIAALVGIWNINFLGAQSHAVLPYDQYLERFPAYLQQLEMESNGKHVTRGGASVNYATGNVIWGAPGTNGQHAFFQLLHQGTPLITADFLASAESHNPLGEHHQILLSNFFAQTEALMKGKDEAEVRAELEEANLAKGEVEALIPHKLFDGNRPSNSFLFSKLTPWTLGALIAFYEHKVFTQGLIWDINSFDQWGVELGKQLATTILPELQGGEEVNSHDSSTNGLINYYKRIRHL
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 61868 Sequence Length: 549 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
Q2JX86
MDSLQLWQRYCDWLYYHPELEIFVDISRIRFTPAQVEALRPLFARAFAEMQALEAGAIANPDEGRQVGHYWLRAPELAPTAEIRQAIQDCVEQVESFAKKIHCGTIPASGGGRFTELLWIGIGGSALGPQFVAEALAPLQPPLNIHFIDNTDPDGFDRVLGRLAGKLGQTLVVVTSKSGNTPEPRNALVEVELAYRKAGIPFSAHAVAITGPGSQLEQQARQEGWLAVFPIFDWVGGRTSETSAVGLLPAALQGIDIRALLAGAATMDKATRVPHLERNPAALLAMAWYIVGEGRGRKDMVVLPYKDRLALFSRYLQQLVMESLGKSHDLQGNRVEQGLTVYGNKGTTDQHAYVQQLRDGLNNFFVTFIEVLQDREPGIPSPFVEPEVTSGDYLDGLLQGTRQALYENGRDSVTITLPRVDARSVGALIALYERAVGLYASLIQVNAYHQPGVEAGKKAASAVLQLQRQVLEVMREQKGSLTLPQLAEKLSCPERIETLYWIVRHLQANGRSLVLVGDPGRPLELSIQPRPA
Function: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Catalytic Activity: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Sequence Mass (Da): 58462 Sequence Length: 532 Pathway: Carbohydrate biosynthesis; gluconeogenesis. Subcellular Location: Cytoplasm EC: 5.3.1.9
P22256
MNSNKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHPKVVAAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGTIAFSGAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYPCPLHGISEDDAIASIHRIFKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADEVQSGAGRTGTLFAMEQMGVAPDLTTFAKSIAGGFPLAGVTGRAEVMDAVAPGGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPEIGDVRGLGAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIRQGLEIISQCFDEAKQ
Function: Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA) and glutamate . Thereby functions in a GABA degradation pathway that allows some E.coli strains to utilize GABA as a nitrogen source for growth . Also catalyzes the conversion of 5-aminovalerate to glutarate semialdehyde, as part of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate . Catalytic Activity: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde Sequence Mass (Da): 45775 Sequence Length: 426 Pathway: Amino-acid degradation; 4-aminobutanoate degradation. EC: 2.6.1.19
P80404
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
Cofactor: Binds 1 [2Fe-2S] cluster per homodimer. Function: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively . Can also convert delta-aminovalerate and beta-alanine (By similarity). Catalytic Activity: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde Sequence Mass (Da): 56439 Sequence Length: 500 Subcellular Location: Mitochondrion matrix EC: 2.6.1.19
P40829
MTSVEQSRQLVTEIPGPVSLELAKRLNAAVPRGVGVTLPVFVTRAAGGVIEDVDGNRLIDLGSGIAVTTIGNSSPRVVDAVRAQVADFTHTCFIITPYEEYVAVTEQLNRITPGSGEKRSVLFNSGAEAVENSIKVARSYTRKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPLSYPYRDGLLNKDLATDGKLAGARAINVIEKQVGADDLAAVIIEPIQGEGGFIVPAEGFLATLLDWCRKNNVMFIADEVQTGFARTGAMFACEHDGIVPDLICTAKGIADGLPLAAVTGRAEIMNAPHVSGLGGTFGGNPVACAAALATITTIENDGLIQRAQQIERLITDRLLRLQDADDRIGDVRGRGAMIAVELVKSGTAEPDPELTEKVATAAHATGVIILTCGMFGNIIRLLPPLTISDELLAEGLDILSRILGDF
Catalytic Activity: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde Sequence Mass (Da): 47215 Sequence Length: 446 Pathway: Amino-acid degradation; 4-aminobutanoate degradation. EC: 2.6.1.19
P50554
MAFLLTTRRLVCSSQKNLHLFTPGSRYISQAAAKVDFEFDYDGPLMKTEVPGPRSQELMKQLNTIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYNHPALAKLVQQPQNASTFINRPALGILPPENFVDKLRESLMSVAPKGMCQLITMACGSCSNENAFKTIFMWYRSKERGQRGFSKEELETCMVNQSPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVTDNQQEEARCLEEVEDLIVKYRKKKRTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMSFSKKMMTGGFFHKEEFRPSAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNVAHAGKTLLTGLLDLQAQYPQFVSRVRGRGTFCSFDTPDEAIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSGILADFK
Cofactor: Binds 1 [2Fe-2S] cluster per homodimer. Function: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively . Can also convert delta-aminovalerate and beta-alanine . Catalytic Activity: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde Sequence Mass (Da): 56456 Sequence Length: 500 Subcellular Location: Mitochondrion matrix EC: 2.6.1.19
P32503
MLRFVTKNSQDKSSDLFSICSDRGTFVAHNRVRTDFKFDNLVFNRVYGVSQKFTLVGNPTVCFNEGSSYLEGIAKKYLTLDGGLAIDNVLNELRSTCGIPGNAVASHAYNITSWRWYDNHVALLMNMLRAYHLQVLTEQGQYSAGDIPMYHDGHVKIKLPVTIDDTAGPTQFAWPSDRSTDSYPDWAQFSESFPSIDVPYLDVRPLTVTEVNFVLMMMSKWHRRTNLAIDYEAPQLADKFAYRHALTVQDADEWIEGDRTDDQFRPPSSKVMLSALRKYVNHNRLYNQFYTAAQLLAQIMMKPVPNCAEGYAWLMHDALVNIPKFGSIRGRYPFLLSGDAALIQATALEDWSAIMAKPELVFTYAMQVSVALNTGLYLRRVKKTGFGTTIDDSYEDGAFLQPETFVQAALACCTGQDAPLNGMSDVYVTYPDLLEFDAVTQVPITVIEPAGYNIVDDHLVVVGVPVACSPYMIFPVAAFDTANPYCGNFVIKAANKYLRKGAVYDKLEAWKLAWALRVAGYDTHFKVYGDTHGLTKFYADNGDTWTHIPEFVTDGDVMEVFVTAIERRARHFVELPRLNSPAFFRSVEVSTTIYDTHVQAGAHAVYHASRINLDYVKPVSTGIQVINAGELKNYWGSVRRTQQGLGVVGLTMPAVMPTGEPTAGAAHEELIEQADNVLVE
Function: Capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry, 40 nm in diameter, and consisting of 60 capsid proteins asymmetric dimers. The capsid encapsulates the genomic dsRNA and the polymerase and remains intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of the virion and are extruded into the cytoplasm. PTM: Acetylation is necessary for viral assembly. Sequence Mass (Da): 75994 Sequence Length: 680 Subcellular Location: Virion
P27400
MGDHNLNVQELLNLFQNLGIPRQPNHREVIGLRMLGGWWGPGTRYILVSIFLQDDSGQPLQQPRWRPEGRPVNPLVHNTIEAPWGELRQAFEDLDVAEGTLRFGPLANGNWIPGDEYSMEFQPPLAQEIAQMQRDELEEILDITGQICAQVIDLVDMQDAQIRGLERRIQDRLGLRDNLPVAGIQAPPSSPIGQPIASSSLQPIPGSSSSPADLDGIWTPRQIDPRLSRVAYNPFLPGSSDGSGGSIPVQPSAPPAVLPSLPSLPAPVSQPIIQYVAQPPVPAPQAIPIQHIRAVTGNTPTNPRDIPMWLGRHSAAIEGVFPMTTPDLRCRVVNALIGGSLGLSLEPIHCVNWAAVVAALYVRTHGSYPIHELANVLRAVVTQEGVATGFQLGIMLSNQDYNLVWGILRPLLPGQAVVTAMQQRLDQEVNDAARITSFNGHLNDIYQLLGLNARGQSIARAQSASTSGNSASAGRGRRGQRTQQQAGRQQQQQTRRTNQGNQGQRDNNQRQSSGGNQGQRGQGGYDLRPRTYQPQRYGGGRGRRWNDNQQQQQAQPGRSSDQPRSQSQQPQPEARGDQSRTSGAGRGQQGRGNQNRNQRRADANNTRNVDTVTATTTSSSTASSGQNGSSTTPPASGSRNQGD
Function: Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity). PTM: Specific enzymatic cleavages in vivo by viral protease yield mature proteins. The protease is not cleaved off from Pol. Since cleavage efficiency is not optimal for all sites, intermediary molecules are expressed (By similarity). Sequence Mass (Da): 69786 Sequence Length: 643 Domain: Gag protein contains 3 glycine-arginine motifs (GR-boxes) necessary for RNA packaging, the first of which has nucleic acid binding properties in vitro. Subcellular Location: Virion
Q87039
MASGSNVEEYELDVEALVVILRDRNIGRNPLHGEIIGLRLTEGWWGQLERFQMVRLILQDEDNEPLQRPRHEIIPRAVNPHTMFVLSGPLAELQLAFQDLDLPEGPLRFGPLANGHYVEGDPYSRSYRPVTMAETAQMTRDELEDTLNTQSEIEIQMINLLELYEVETRALRRQLAERSSIGQGGISPGASHSRPPVSSFSGLPSLPAIPGIHTRAPSPPRATSTPGNIPRSLGDDNMPSSSFAGPSQPRVSFHPGNPFAEAEGHRPRSQSRERRRDIPSAPVISAPVPSAPPMIQYIPVPPPPPVGAVIPIQHIRSVTGEPPRNPREIPIWLGRNAPAIDGVFPTTTPDLRCRIINALLGGNLGLSLTPGDCITWDSAVATLFIRTYGQYPLHQLGNVLKGIADQEGVATAYTLGMMLSGQNYQLVSGIIRGYLPGQAVVTAMQQRLDQEIDDQTRAETFIQHLNAVYEILGLNARGQSIRASVTPQPRPSRGRGRGQSAPEPSQGPVNSGRGRQCPAPGQNDRGSNIQNQGQENSSQGGYNLRSRTYQPQRYGGGRGRRWNENTNNSETRPTEQSPQTPRPIQAGSGVRGNQSQTYKPAAGRGGRGNQNRNQRSSGAGDSRAVNTVTQSATSSTDESSSTTTAAPSGGQGN
Function: Involved in capsid formation and genome binding. Shortly after infection, interaction between incoming particle-associated Gag proteins and host dynein allows centrosomal targeting of the viral genome (associated to Gag), prior to nucleus translocation and integration into host genome (By similarity). PTM: Specific enzymatic cleavages in vivo by viral protease yield mature proteins. The protease is not cleaved off from Pol. Since cleavage efficiency is not optimal for all sites, intermediary molecules are expressed (By similarity). Sequence Mass (Da): 70762 Sequence Length: 653 Domain: Gag protein contains 3 glycine-arginine motifs (GR-boxes) necessary for RNA packaging, the first of which has nucleic acid binding properties in vitro. Subcellular Location: Virion
Q02843
MGGGHSALSGRSLDTFEKIRLRPNGKKKYQIKHLIWAGKEMERFGLHEKLLETKEGCQKIIEVLTPLEPTGSEGLKALFNLCCVIWCIHAEQKVKDTEEAVVTVKQHYHLVDKNEKAAKKKNETTAPPGGESRNYPVVNQNNAWVHQPLSPRTLNAWVKCVEEKRWGAEVVPMFQALSEGCLSYDVNQMLNVIGDHQGALQILKEVINEEAAEWDRTHRPPAGPLPAGQLRDPTGSDIAGTTSSIQEQIEWTFNANPRIDVGAQYRKWVILGLQKVVQMYNPQKVLDIRQGPKEPFQDYVDRFYKALRAEQAPQDVKNWMTQTLLIQNANPDCKLILKGLGMNPTLEEMLIACQGVGGPQHKAKLMVEMMSNGQNMVQVGPQKKGPRGPLKCFNCGKFGHMQRECKAPRQIKCFKCGKIGHMAKDCKNGQANFLGYGHWGGAKPRNFVQYRGDTVGLEPTAPPMETAYDPAKKLLQQYAEKGQRLREEREQTRKQKEKEVEDVSLSSLFGGDQ
Function: Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu (By similarity). PTM: Capsid protein p24 is phosphorylated. Location Topology: Lipid-anchor Sequence Mass (Da): 57702 Sequence Length: 513 Domain: Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. p6-gag contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 (By similarity). Subcellular Location: Virion
P22381
MGNGNSALLGTDLDKFEKIRLKRGGKKCYRLKHLCWCKGELDRFGLSDKLLETQQGCEKILSVCWPLYDQGSDNLKALVGTVCVVACIHAGIEIKSTQDALKKLKVITRKEEKQEDESKNFPVQRDAAGQYQYTPISPRIIQTWVKTVEEKKWKPEVIPLFSALTEGAISHDLNIMLNAVGDHQGAMQVLKDVINEQAAEWDLTHPQQQPAQPGGGLRTPSGSDIAGTTSTVEEQLAWMNMQQNAINVGTIYKSWIILGMNRLVKSHCPISITDVRQGPKEAFKDYVDRFYNVMRAEQASGEVKMWMQQHLLIENANPECKQILRSLGKGATLEEMLEACQGVGGPQHKARLMAEMMRTVVGQSQNFVQQRGPQRGPVRQPTGRKPICFNCNKEGHVARFFKAPRRKGCWNCGAMDHQKAQCPKPAQQQRVNFLGYGPWGPSKPGNYPAQEVTPTAPPLEEKPLQKTLSTYQKLGRGLRQKMKEEKREEDFHSLSTLFQEDQ
Function: Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu (By similarity). PTM: Capsid protein p24 is phosphorylated. Location Topology: Lipid-anchor Sequence Mass (Da): 56481 Sequence Length: 502 Domain: Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. p6-gag contains one L domain: a PTAP/PSAP motif, which interacts with the UEV domain of TSG101 (By similarity). Subcellular Location: Virion
O81884
MTKIELRALGNTGLKVSAVGFGASPLGSVFGPVAEDDAVATVREAFRLGINFFDTSPYYGGTLSEKMLGKGLKALQVPRSDYIVATKCGRYKEGFDFSAERVRKSIDESLERLQLDYVDILHCHDIEFGSLDQIVSETIPALQKLKQEGKTRFIGITGLPLDIFTYVLDRVPPGTVDVILSYCHYGVNDSTLLDLLPYLKSKGVGVISASPLAMGLLTEQGPPEWHPASPELKSASKAAVAHCKSKGKKITKLALQYSLANKEISSVLVGMSSVSQVEENVAAVTELESLGMDQETLSEVEAILEPVKNLTWPSGIHQN
Function: Catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). Uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). Catalytic Activity: L-galactose + NAD(+) = H(+) + L-galactono-1,4-lactone + NADH Sequence Mass (Da): 34532 Sequence Length: 319 EC: 1.1.1.316
Q88JY0
MGQTRIPCLLMRGGTSKGAYFLHDDLPAPGPLRDRVLLAVMGSPDARQIDGIGGADSLTSKVAIIRASQRDDADVDYLFAQVVVDEARVDYGQNCGNILAGVGPFALERGLVAASGASTPVRIFMENTGQIAVAQVPTADGQVEYAGDTRIDGVPGRAAALVVTFADVAGASCGALLPTGNSRDCVEGVEVTCIDNGMPVVLLCAEDLGVTGYEPCETLEADSALKTRLEAIRLQLGPRMNLGDVSQRNVPKMCLLSAPRNGGTVNTRSFIPHRCHASIGVFGAVSVATACLIEGSVAQGLASTSGGDRQRLAVEHPSGEFTVEISLEHGVIKGCGLVRTARLLFDGVVCIGRDTWGGPEK
Function: Catalyzes the tautomerization of the 4-oxalomesaconic acid keto (OMAketo) generated by GalA dioxygenase to 4-oxalomesaconic acid enol (OMAenol). Mediates the second step in gallate degradation pathway. Catalytic Activity: (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate Sequence Mass (Da): 37559 Sequence Length: 361 EC: 5.3.2.8
P55180
MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRDLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNGYKSAE
Function: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity). Catalytic Activity: UDP-alpha-D-glucose = UDP-alpha-D-galactose Sequence Mass (Da): 37009 Sequence Length: 339 Pathway: Carbohydrate metabolism; galactose metabolism. EC: 5.1.3.2
E8MF10
MTTVLVTGGAGFIATHTDIELLNKGYDVISVDNYGNSSPVALERVEQITGKPVKRYDGDVRDEALMERVFAENNIDWVIHFAGLKAVGESVAKPIEYYDNNLYSTLVLLKVMKKHNVKKIIFSSSATVYGTPKELPITEETPTGGTTNPYGTSKLFQEQILRDVHVADPSWTIVLLRYFNPVGAHESGLLGEDPKGIPANLTPYVAKVAVGELKEVQVYGDDYDTPDGTGVRDYIHVVDLAKGHVAVIDHIDKEGVFVYNLGTGHGYSVLEVIKAYEKAAGHPIPYAIKPRRPGDIAACYADASKAEKELGWKAELTIDDMAASSLNWQTKNPNGFRDAE
Function: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. Can also epimerize UDP-GalNAc to UDP-GlcNAc. Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria. Catalytic Activity: UDP-alpha-D-glucose = UDP-alpha-D-galactose Sequence Mass (Da): 37226 Sequence Length: 340 Pathway: Carbohydrate metabolism; galactose metabolism. EC: 5.1.3.2
Q3T105
MAEKVLVTGGAGYIGSHTVLELLEAGYSPMVIDNFHNAIRGGGSMPESLRRVQDLTGRSVEFEEMDILDQAALQRLFKKHSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKAWNAVLLRYFNPIGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREVLNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLALKELGWSAALGLDRMCEDLWRWQKQNPSGFGTQA
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. Catalytic Activity: UDP-alpha-D-glucose = UDP-alpha-D-galactose Sequence Mass (Da): 38254 Sequence Length: 348 Pathway: Carbohydrate metabolism; galactose metabolism. EC: 5.1.3.2
Q564Q1
MHILVTGAAGFIGSHTVLELLNSGYTVLCIDNFANAISVTDEHGNAISLKRVAQLTGKDVPFQNVDVCDEAALEKVFSENKFDGIIHLAALKAVGESVAKPLQYYSNNLVASLNLIQMCLKYNVKNFVFSSSATVYGPPSELPITEKSQTGQGITNPYGQTKYMMEQILIDVGKANPEWNVVLLRYFNPVGAHKSGLIGEDPKGVPNNLMPYVSQVAIGKLPVLTIYGDQFDTVDGTGVRDYIHVVDLAKGHVKAFDRIKTVGNIGTEIYNLGTGVGYSVRQMVDALKKVSGRDIPVKIGVPRPGDVASVYCDPSLAQEKLGWRAETGLEEMCADLWNWQTKNPQGFSA
Function: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important for the synthesis of glycoproteins and glycolipids. Catalytic Activity: UDP-alpha-D-glucose = UDP-alpha-D-galactose Sequence Mass (Da): 37883 Sequence Length: 349 Pathway: Carbohydrate metabolism; galactose metabolism. EC: 5.1.3.2
Q45291
MKLLVTGGAGYVGSVAAAVLLEHGHDVTIIDNFSTGNREAVPADARLIEGDVNDVVEEVLSEGGFEGVVHFAARSLVGESVEKPNEYWHDNVVTALTLLDAMRAHGVNNLVFSSTAATYGEPDVVPITEDMPTQPTNAYGATKLSIDYAITSYAAAFGLAATSLRYFNVAGAYGNIGENREVETHLIPLVLQVATGHREKTFMFGDDWPTPDGTAVRDYIHILDLAKAHVLALESNEAGKHRIFNLGSGDGYSVKQVVEMCREVTGHPIPAEVAPRRAGDPATLIASSEKAKQELGWTPEHTDLRTIVEDAWAFTSALGDRSHAAKKKA
Function: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (Probable). Catalytic Activity: UDP-alpha-D-glucose = UDP-alpha-D-galactose Sequence Mass (Da): 35263 Sequence Length: 329 Pathway: Carbohydrate metabolism; galactose metabolism. EC: 5.1.3.2
Q8I136
MLPRMLKMKTVGTVLAVIWLFGLAFIYVQSTSSSLRPPGRHPPPLPQLDPLIPQNPPQNDEIRPKKSAPPIPTINLAEDTTIHERTEKDVTWKTFDVEKFLNKGKWHQGEDKYKANSFNQEASDALNPTRKIPDSREPQCRDVDYSKVGMQPTTVIITYHNEARSSLLRTVFSVFNQSPEELLLEIVLVDDNSQDVEIGKELAQIQRITVLRNNQREGLIRSRVKGAQVARAPVLTFLDSHIECNQKWLEPLLARIAENPKAVVAPIIDVINVDNFNYVGASADLRGGFDWTLVFRWEFMNEQLRKERHAHPTAPIRSPTMAGGLFAISKEWFNELGTYDLDMEVWGGENLEMSFRVWQCGGSLEIMPCSRVGHVFRKKHPYTFPGGSGNVFQKNTRRAAEVWMDEYKAIYLKNVPSARFVNFGDITDRLAIRDRLQCKSFKWYLENVYPQLEIPRKTPGKSFQMKIGNLCLDSMARKESEAPGLFGCHGTGGNQEWVFDQLTKTFKNAISQLCLDFSSNTENKTVTMVKCENLRPDTMVVEKNGWLTQGGKCLTVNQGSGGDWLIYGAHCELNNGAQRWIFEKLDTYE
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 67031 Sequence Length: 589 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q8IA42
MAIKKRYVKRLLRKVVLLLVVIVTVSLVTTLVVERRMKNAAELTEQLDPNGDPITPVFRAANIHPTRKAPRPPFQDRNSVVDIPRSDKLQGFRLPEPKGERKDWHDYAAMEADRKRSGFGEHGVAVKIENPDEKQLEKEHYEMNGFNGLISDRISVNRSVPDLRLEACKTRKYLAKLPNISVIFIFFNEHFNTLLRSIYSVINRTPPELLKQIVLVDDGSEWDVLKQPLDDYVQQHFPHLVTIVRNPERQGLIGARIAGAKVAVGQVMVFFDSHIEVNYNWLPPLIEPIAINPKISTCPMVDTISHEDFSYFSGNKDGARGGFDWKMLYKQLPVLPEDALDKSMPYRSPVMMGGLFAINTDFFWDLGGYDDQLDIWGGEQYELSFKIWMCGGMLLDVPCSRVAHIFRGPMKPRGNPRGHNFVAKNHKRVAEVWMDEYKQYVYKRDPKTYDNLDAGDLTRQRGVRERLKCKSFHWFMTEVAPDFLVKFPPVEPPSYAAGIIQNVANPVYCLDNMGKSTEEAVGMFSCADNRTHPQPNQFWELSIFRDLRMKGFDSVCLDVHEGPPNATVWMWSCHSQGGNQFWYYDRQTQRLVHGENNKRCLEGFVENGIAKVVANSCENGNDRQRWEFGFVNHTMLDTFYDGLK
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the diglycosylated Muc5AC-3/13 as substrate. Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 74040 Sequence Length: 644 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q8N4A0
MAVRWTWAGKSCLLLAFLTVAYIFVELLVSTFHASAGAGRARELGSRRLSDLQKNTEDLSRPLYKKPPADSRALGEWGKASKLQLNEDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVIIAFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLDRVRLIRTNKREGLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQIGEPMIGGFDWRLTFQWHSVPKQERDRRISRIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPNFLQNTARAAEVWMDEYKEHFYNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVPEDRPGWHGAIRSRGISSECLDYNSPDNNPTGANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQKNYVGMQNCPKDGFPVPANIIWHFKEDGTIFHPHSGLCLSAYRTPEGRPDVQMRTCDALDKNQIWSFEK
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG. Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 66666 Sequence Length: 578 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q95ZJ1
MIIFKKKAILKVLLLVPVFWICSLIFFAATSNDSSQIGSNNDLANKIAEANFHPKAAKQDVIQGFGPPIEPEPVVENNKVEEEEQPGGNLAKPKFMVDPNDPIYKKGDAAQAGELGKAVVVDKTKLSTEEKAKYDKGMLNNAFNQYASDMISVHRTLPTNIDAECKTEKYNENLPRTSVIICFHNEAWSVLLRTVHSVLERTPDHLLEEVVLVDDFSDMDHTKRPLEEYMSQFGGKVKILRMEKREGLIRARLRGAAVATGEVLTYLDSHCECMEGWMEPLLDRIKRDPTTVVCPVIDVIDDNTFEYHHSKAYFTSVGGFDWGLQFNWHSIPERDRKNRTRPIDPVRSPTMAGGLFSIDKKYFEKLGTYDPGFDIWGGENLELSFKIWMCGGTLEIVPCSHVGHVFRKRSPYKWRTGVNVLKRNSIRLAEVWLDDYKTYYYERINNQLGDFGDISSRKKLREDLGCKSFKWYLDNIYPELFVPGESVAKGEVRNSAVQPARCLDCMVGRHEKNRPVGTYQCHGQGGNQYWMLSKDGEIRRDESCVDYAGSDVMVFPCHGMKGNQEWRYNHDTGRLQHAVSQKCLGMTKDGAKLEMVACQYDDPYQHWKFKEYNEAKAIEHGAKPPS
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 71382 Sequence Length: 626 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q6WV17
MTFSTFTRKMRGRMRSNTCRIVLLTSLVWVIFDFVLIARYSDCIGKDGWRCKRSGEYDVELPNAERLVDDNQLVDDNEINTEKSLDGESGGALIMGQGFASGGISMTYPSVVLKKWFLAPSVQEAKGKPGEMGKPVKIPADMKDLMKEKFKENQFNLLASDMISLNRSLTDVRHEGCRRKHYASKLPTTSIVIVFHNEAWTTLLRTVWSVINRSPRALLKEIILVDDASERDFLGKQLEEYVAKLPVKTFVLRTEKRSGLIRARLLGAEHVSGEVITFLDAHCECTEGWLEPLLARIVQNRRTVVCPIIDVISDETFEYITASDSTWGGFNWKLNFRWYRVPSREMARRNNDRTAPLRTPTMAGGLFSIDKDYFYEIGSYDEGMDIWGGENLEMSFRIWQCGGILEIIPCSHVGHVFRDKSPYTFPGGVAKIVLHNAARVAEVWLDEWRDFYYSMSTGARKASAGDVSDRKALRDRLKCKSFRWYLENVYPESLMPLDYYYLGEIRNAETETCLDTMGRKYNEKVGISYCHGLGGNQVFAYTKRQQIMSDDLCLDASSSNGPVNMVRCHNMGGNQEWVYDAEEKWIRHTNTGQCLQRATRDDANTPLLRPCSYGKGQQWLMESKFKWQAH
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor . It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers EA2 as substrate . In the larval midgut, required for O-glycosylation of apical and luminal proteins within copper cells enabling proper gut acidification . Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 72097 Sequence Length: 630 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q7Z7M9
MNRIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTRVIKEDIVRRERIGFRVQPDQGKIFYSSIKEMKPPLRGHGKGAWGKENVRKTEESVLKVEVDLDQTQRERKMQNALGRGKVVPLWHPAHLQTLPVTPNKQKTDGRGTKPEASSHQGTPKQTTAQGAPKTSFIAAKGTQVVKISVHMGRVSLKQEPRKSHSPSSDTSKLAAERDLNVTISLSTDRPKQRSQAVANERAHPASTAVPKSGEAMALNKTKTQSKEVNANKHKANTSLPFPKFTVNSNRLRKQSINETPLGSLSKDDGARGAHGKKLNFSESHLVIITKEEEQKADPKEVSNSKTKTIFPKVLGKSQSKHISRNRSEMSSSSLAPHRVPLSQTNHALTGGLEPAKINITAKAPSTEYNQSHIKALLPEDSGTHQVLRIDVTLSPRDPKAPGQFGRPVVVPHGKEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMCFVDEVWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDNFQRGIFVWPMNFGWRTIPPDVIAKNRIKETDTIRCPVMAGGLFSIDKSYFFELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCKSFKWYLENVFPDLRAPIVRASGVLINVALGKCISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEWCIAPIPDKGAVRLHPCDNRNKGLKWLHKSTSVFHPELVNHIVFENNQQLLCLEGNFSQKILKVAACDPVKPYQKWKFEKYYEA
Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity). Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 106266 Sequence Length: 940 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
O61394
MIASLIRSRRRSRRCVVYSVFLFGFLALWGSFALALVFLSDMYIGEDQISTQKAIKPIARSNYHVVVGHYNGNLPEDKKRNLTSEELNANLYAPHDDWGEGGAGVSHLTPEQQKLADSTFAVNQFNLLVSDGISVRRSLPEIRKPSCRNMTYPDNLPTTSVIIVYHNEAYSTLLRTVWSVIDRSPKELLKEIILVDDFSDREFLRYPTLDTTLKPLPTDIKIIRSKERVGLIRARMMGAQEAQGDVLTFLDSHCECTKGWLEPLLTRIKLNRKAVPCPVIDIINDNTFQYQKGIEMFRGGFNWNLQFRWYGMPTAMAKQHLLDPTGPIESPTMAGGLFSINRNYFEELGEYDPGMDIWGGENLEMSFRIWQCGGRVEILPCSHVGHVFRKSSPHDFPGKSSGKVLNTNLLRVAEVWMDDWKHYFYKIAPQAHRMRSSIDVSERVELRKKLNCKSFKWYLQNVFQDHFLPTPLDRFGRMTSSSNSSVCLAWTLRSSGIKTASTADCLKIFHKTQLWLYTGDRRIRTDEHLCLSVVQLLHTTSDWKIQLKECAGFDTEYWDFKPKIGRFQNRKTGLCLASPDIFDPTKDEFNPPIVQKCRSSNDRQNWTITEMSWLPEHP
Function: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 71115 Sequence Length: 618 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.-
Q6WV16
MRRPNLKWIVKASLLLLISLTLFVLITSWISSTPYTNKPVHHGVEPVPEKAGLSGDVKVKVPAIKQPEPQKPQEPDFEEDPELQKIDEPEPVEEEVDNPHPADDEPQQQPQEELQMAAPADASVKKDWHDYTFMEKDAKRVGLGEGGKASTLDDESQRDLEKRMSLENGFNALLSDSISVNRSVPDIRHPLCRKKEYVAKLPTVSVIIIFYNEYLSVLMRSVHSLINRSPPELMKEIILVDDHSDREYLGKELETYIAEHFKWVRVVRLPRRTGLIGARAAGARNATAEVLIFLDSHVEANYNWLPPLLEPIALNKRTAVCPFIDVIDHTNFHYRAQDEGARGAFDWEFFYKRLPLLPEDLKHPADPFKSPIMAGGLFAISREFFWELGGYDEGLDIWGGEQYELSFKIWMCGGEMYDAPCSRIGHIYRGPRNHQPSPRKGDYLHKNYKRVAEVWMDEYKNYLYSHGDGLYESVDPGDLTEQKAIRTKLNCKSFKWFMEEVAFDLMKTYPPVDPPSYAMGALQNVGNQNLCLDTLGRKKHNKMGMYACADNIKTPQRTQFWELSWKRDLRLRRKKECLDVQIWDANAPVWLWDCHSQGGNQYWYYDYRHKQLKHGTEGRRCLELLPFSQEVVANKCDTDNRFQQWNFGSFNKTALDNYSQDLVLSL
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide . In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties . Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified . Prefers the diglycosylated Muc5AC-3/13 as substrate . Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure . Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 76972 Sequence Length: 666 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
O61397
MIIARKKLQLQRLWRQRGCRVATYICLGVLVLFGFVYNSKGNSMSSIKSDSAAQQFDDLDDLTNKELPGGPDPNTIFRGSELGNYEPKEPEIPSNQPGEHGKPVPVTDEEGMAAGRAAEKEFGFNTYVSDMISMNRTIPDIRPEECKHWDYPEKLPTVSVVVVFHNEGWTPLLRTVHSVLLRSPPELIEQVVMVDDDSDKPHLKEKLDKYVTRFNGKVIVVRTEQREGLINARSIGAKHSTGEVVLFLDAHCEVNTNWLPPLLAPIKRNRKVMTVPVIDGIDSNSWEYRSVYGSPNAHHSGIFEWGLLYKETQITERETAHRKHNSQPFRSPTHAGGLFAINRLWFKELGYYDEGLQIWGGEQYELSFKIWQCGGGIVFVPCSHVGHVYRSHMPYSFGKFSGKPVISINMMRVVKTWMDDYSKYYLTREPQATNVNPGDISAQLALRDKLQCKSFKWYMENVAYDVLKSYPMLPPNDVWGEARNPATGKCLDRMGGIPGPMGATGCHGYGGNQLIRLNVQGQMAQGEWCLTANGIRIQANHCVKGTVNGFWSYDRKTKQIIHSQKRQCITVSESGSEVTLQTCTEDNERQKFVWKEFYQSS
Function: Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 68108 Sequence Length: 601 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.-
Q8MV48
MRVSTIRSGRICRLALCLLVLLPLLYLLANWSDHHKRVQEAYHTRFGGPKFAHQRLEGRPREVPKLVDGLGNFEPKDVKPRSGPGENGEAHSLSPDKKHMSDASEMEYGMNIACSDEISMHRSVRDTRLEECRHWDYPFDLPRTSVIIVFHNEGFSVLMRTVHSVIDRSPTHMLHEIILVDDFSDKENLRSQLDEYVLQFKGLVKVIRNKEREGLIRTRSRGAMEATGEVIVFLDAHCEVNTNWLPPLLAPIYRDRTVMTVPIIDGIDHKNFEYRPVYGTDNHFRGIFEWGMLYKENEVPRREQRRRAHNSEPYRSPTHAGGLFAINREYFLELGAYDPGLLVWGGENFELSFKIWQCGGSIEWVPCSRVGHVYRGFMPYNFGKLASKKKGPLITINYKRVIETWFDDTHKEYFYTREPLARYLDMGDISEQLALKKRLNCKSFQWFMDHIAYDVYDKFPGLPANLHWGELRSVASDGCLDSMGHQPPAIMGLTYCHGGGNNQLVRLNAAGQLGVGERCVEADRQGIKLAVCRLGTVDGPWQYNEHTKHLMHRVHKKCMALHPATQQLSLGHCDVNDSYQQWWFKEIRPRW
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide . In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties . Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Prefers the monoglycosylated Muc5AC-3 as substrate . Might have a role in protein O-glycosylation in the Golgi and thereby in establishing and/or maintaining a proper secretory apparatus structure . Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 68333 Sequence Length: 591 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
Q86SF2
MRLKIGFILRSLLVVGSFLGLVVLWSSLTPRPDDPSPLSRMREDRDVNDPMPNRGGNGLAPGEDRFKPVVPWPHVEGVEVDLESIRRINKAKNEQEHHAGGDSQKDIMQRQYLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPEFKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSMLWKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPIYVGSSPTLKNYVRVVEVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAYDITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQLFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTHIPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
Function: Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified. Catalytic Activity: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 75389 Sequence Length: 657 Domain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding. Pathway: Protein modification; protein glycosylation. Subcellular Location: Golgi apparatus membrane EC: 2.4.1.41
P11862
MMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPTKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPVQSKSPTLKDMNPDNYLVVSATYKAKKEIK
Function: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process. PTM: Cleaved, during apoptosis, on a specific aspartic residue by caspases. Location Topology: Peripheral membrane protein Sequence Mass (Da): 34901 Sequence Length: 314 Subcellular Location: Cytoplasm
Q9USU5
MVSFTKFTLQLLSASAAFAYFEPLTIKGRKFFKNDTQFYIKGVAYQPAVDAEETSTIVDPLAEVNYKNCTEDAKIISNLGANVIRVYAVNASLNHDKCMEAFRNESIYVFLDLANPKTGIDRDTPTWNTDQFSSYQSVIDTFQKYNNTGAFFAGNEVVNNASNAPAVAYVRAAVRDSKNYIKSKKYRTIPVGYAGADIPVVRTELAAYLSCNATKLNNDTNSETDFLGYNMYEWCGHSDFYTSGYAARTQELENFTIPIFLSEFGCNKVTPRVFTEVQAIYSDNMTNVWSGGIVYEYSQEVNDYGLVNVSSTGERVLTTDYNNLKKQWASISPNITYKHSYNPNGTIPECPSRNKTSWAVSANAFPVTPNTTICSNAVKNLKCSANGTPSGSKISQVLSELCYYDNKACSSISSDPYEGTYGNYTGCTGVQQLSIALNAYTQDHGADSCSWGGVGELKA
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Sequence Mass (Da): 50614 Sequence Length: 459 Subcellular Location: Endoplasmic reticulum lumen EC: 2.4.1.-
Q06135
MNKKQNFYAAIIVAIFLCLQLSHGSSGVSFEKTPAIKIVGNKFFDSESGEQFFIKGIAYQLQRSEEELSNANGAFETSYIDALADPKICLRDIPFLKMLGVNTLRVYAIDPTKSHDICMEALSAEGMYVLLDLSEPDISINRENPSWDVHIFERYKSVIDAMSSFPNLLGYFAGNEVTNDHTNTFASPFVKAAIRDAKEYISHSNHRKIPVGYSTNDDAMTRDNLARYFVCGDVKADFYGINMYEWCGYSTYGTSGYRERTKEFEGYPIPVFFSEFGCNLVRPRPFTEVSALYGNKMSSVWSGGLAYMYFEEENEYGVVKINDNDGVDILPDFKNLKKEFAKADPKGITEEEYLTAKEPTEVESVECPHIAVGVWEANEKLPETPDRSKCACLDEILPCEIVPFGAESGKYEEYFSYLCSKVDCSDILANGKTGEYGEFSDCSVEQKLSLQLSKLYCKIGANDRHCPLNDKNVYFNLESLQPLTSESICKNVFDSIRNITYNHGDYSKSNPSRSKESLNVKYPSSEERENDGTIAFKTSGFVILLISMIAAGILL
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly. PTM: N-glycosylated. Location Topology: Lipid-anchor Sequence Mass (Da): 62362 Sequence Length: 555 Subcellular Location: Cell membrane EC: 2.4.1.-
Q03655
MQLSKSILLAALAATPSLVNAMLPIHIKNYRFIKPSSATNSESDNEVFFVKGVDYQPGGSSGYDADSDTDILSDPEVCARDAYAFQQLGVNTVRIYSLNPDLNHDKCMTIFNNAGIYAILDVNSGNYGESLNRADPSGTYDSLYLSRVFKFIDAFKNYPNVLGFFSGNEVINDQSDYAKIDPPYIRAVQRDMKQYISKHANRSIPVGYSAADNTDLRLATFKYLQCNSLDGNKVNDDLDISKSDFFGLNTYEWCSGTSSWESSGYDKLNSTFEDAVIPLIFSEYGCNKNTPRTFDEVSEGLYGGLKNVFSGGLVYEYTEEANNYGLVKLDDSGSLTYKDDFVNLESQLKNVSLPTTKESEISSDSIYKCDNSAITNIYSGFGTNNFTLPSQPAEIANMIEYGVNGTNTGKILTDYAVPTTFNYTIKNNKDDTISATISYDKANSLNELDVTATTVAKSASTSQSSSRSLTSSTSPSSSTGSSSSTGSSSASSSSKSKGVGNIVNVSFSQSGYLALFAGLISALL
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis (By similarity). PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Location Topology: Lipid-anchor Sequence Mass (Da): 56794 Sequence Length: 524 Subcellular Location: Secreted EC: 2.4.1.-
Q9Y7Y7
MGVANIIYALFLLGPSIFLKATAQTHPIVIKGNAFFDSKTNERFYIRGVDYQPGGSSSLVDPLASRSCKKDVEIFKKLGINTVRVYQVDNSADHDKCMNALSEAGIYVILDLNTYRHSISRAHPALSYNKVYLQHLFATIDAFKGYDNVLGFFSGNEVVNDEDTTAITWVKAVTRDVKAYIKKHSDRHIPVGYSAADVAENRLQLAHYFNCGDESERADFYAFNMYEWCGYSSMTVSGYYDRIKEFSNYSIPLFLSEFGCNTVEINDDTTPNRPFTEIEAIYSHDMTPVFSGGLVYEYSAEPNHYGLVVIDKDDERRVSRNFITLMKQYAKTPNPKGDGGYKKAGSPSKCPANSTQFNAWEKLPEMPEGAKIYMEKGAGEPLGIEGPTNMWSPFHDGDDDESTSRRPKPKNKPSNVTSTTSYTSGMTSSSESGSSKIGVAFCQALFITVLIATLSF
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly. Location Topology: Lipid-anchor Sequence Mass (Da): 50763 Sequence Length: 456 Subcellular Location: Cell membrane EC: 2.4.1.-
Q08271
MMVFSSTFIFLILELVVLCEASVHTIQIKDKHFVDTVTGKPFFIKGVDYQPGGSSDVSEKQDPLSNPDACARDILLFQELGINTVRIYSINPDLNHDACMTMLAMAGIYLILDVNSPLQNQHLNRYEPWTTYNEVYLEHVFKVVEQFSHYNNTLGFFAGNEIVNDKRSAQYSPAYVKELIGTMKNYISAHSPRTIPVGYSAADDLNYRVSLSEYLECKDDDKPENSVDFYGVNSYQWCGQQTMQTSGYDTLVDAYRSYSKPVFFSEFGCNKVLPRQFQEIGYLFSEEMYSVFCGGLVYEFSQEDNNYGLVEYQEDDSVQLLADFEKLKSHYQNIEFPSMKTLKETVQMEETPSCAEDYENLKIESKIAKNLGSSLIKKGVKVEKGKYIDIHEDQLSTNVTILDKHGDRWNGPKKIEIRQSLTLADLEGEEQEDADEDKDDLKRKHRNSASISGPLLPLGLCLLFFTFSLFF
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly. Location Topology: Lipid-anchor Sequence Mass (Da): 53813 Sequence Length: 471 Subcellular Location: Cell membrane EC: 2.4.1.-
O13692
MNFLHFLTTSLLLLGGSRLALADSASSAIKIKGNAFFNSDTNERFYVRGVDYQPGGSSTLVDPLADTSICKRDLPYLQGLNINTIRVYQVDNSANHDECMSALQDAGIYVILDLATSSNSISRLDAASSYNAVFLQGIFATIDAFKNYTNVLGFFAGNEVANTAENSATTTWVKAALRDAKEYISKNSDRDIPVGYSAADVAEIRVQCADFFACGNSSVRADFYGMNMYEWCGADSSFTISGYDQRMEEFANYSIPLFLSEYGCNDVTKESDGTPDRPFDEVDAIFSSEMSSVFSGGLVYQYSEEGNNYGLVVIDGDNVTISKNYETLKEKYASAANYTGDGDYSSSPATLTCPADDSYFTSFPLPTMPSEAKGFIESGAGQPLGFNAPSNQEFSANATALVSPGPHSVSTTINTNIVQATISQSSTSGSSSGSSSASTTASSSSVSSGSSISSGSSSMSTSYTSASGSSAHSSGSSSGSSSATSSASTFNLSRFYVFAGILAISGLVFA
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Location Topology: Lipid-anchor Sequence Mass (Da): 53693 Sequence Length: 510 Subcellular Location: Secreted