ids
stringlengths
6
10
seqs
stringlengths
11
1.02k
texts
stringlengths
108
11.1k
Q08193
MLLRSLTSAFVLSAGLAQAASSSNSSTPSIEIKGNAFFNSESGERFYIRGVDYQPGGSSNLTDPLADASVCDRDVPVLKDLGINTVRVYTVDNSQDHSHCMKLLQENGIYLILDVNTPTSAISRYDPACSYNADYLQNVFATIDTFADYDNVLGFFAGNEVINSVNTTNTATYVKAVVRDMKKYIKARKYRQIPVGYSAADIVANRQLAAEYFNCGDEADARIDMFGVNDYSWCGESSFVVSGYSTKMKLYQDYSVPVFLSEFGCNQVKSSRPFTEIEAIYSTQMSSVFSGGLVYEYSNETNNYGLVQIDGDKVTKLTDFENLKNEYSKVSNPEGNGGYSTSNNYSTCPDYEKGVWEANNTLPAMPSAASAYFTSGAGSPMGTGIATQQSCDAKDDDDEEDDDTSSSSSSSSSSSSSASSSSESSSSTSKASSSSPSASETSLLKSAASATSSSQSSSKSKGAAGIIEIPLIFRALAELYNLVL
Function: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis. PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Location Topology: Lipid-anchor Sequence Mass (Da): 51870 Sequence Length: 484 Subcellular Location: Secreted EC: 2.4.1.-
Q14393
MAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. PTM: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Sequence Mass (Da): 74925 Sequence Length: 678 Subcellular Location: Secreted
P46689
MAISKALIASLLISLLVLQLVQADVENSQKKNGYAKKIDCGSACVARCRLSRRPRLCHRACGTCCYRCNCVPPGTYGNYDKCQCYASLTTHGGRRKCP
Function: Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation. PTM: Six disulfide bonds may be present. Sequence Mass (Da): 10745 Sequence Length: 98 Subcellular Location: Secreted
P46688
MAVFRSTLVLLLIIVCLTTYELHVHAADGAKVGEGVVKIDCGGRCKDRCSKSSRTKLCLRACNSCCSRCNCVPPGTSGNTHLCPCYASITTHGGRLKCP
Function: Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation. PTM: Six disulfide bonds may be present. Sequence Mass (Da): 10531 Sequence Length: 99 Subcellular Location: Secreted
P46687
MAIFRSTLVLLLILFCLTTFELHVHAAEDSQVGEGVVKIDCGGRCKGRCSKSSRPNLCLRACNSCCYRCNCVPPGTAGNHHLCPCYASITTRGGRLKCP
Function: Gibberellin-regulated protein that may function in hormonal controlled steps of development such as seed germination, flowering and seed maturation. PTM: Six disulfide bonds may be present. Sequence Mass (Da): 10705 Sequence Length: 99 Subcellular Location: Secreted
Q6AQK1
MKAYELSIEEAAAKLRAGDISSVELTQSCLQRIGDVEDRVKGFITVDEEGALAQAKAADKALQNGETNPLCGIPMSIKDLLAVKDLPMTCGSKMLEKFIAPYNATIVDKLQGAGAVNLGKVTMDEFAMGSTSETCAFGVPQNPWKEGYVAGGSSGGSAVTVAAQECFFSIGTDTGGSIRQPAALCGVVGMKPTYGRVSRYGLTAFASSLDQAGPLCRTVADTALVMNSICGYDPMDSTSINQEVPDYTASLVEGVKGLRIGIPKEYFAKGLDSEVEKVVRNAIAVLASAGAEIVDVSLPHTEYCVAVYYLIAPAEASTNLSRYDGALYGYRDLESKTLEDMYKDTRSAGFGDEVKKRILIGTYALSSGYYDAYYKKASQVRTLIIEDFKNAYRSCDVLLSPVTPTPAWKLGAKSDDPLAIYLSDIMTVSANLAGIPGMSVPGGFTEDGLPVGIQLQGSHFQEEILLKVAYNLEKLLAIQPGKLDF
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 51681 Sequence Length: 485 EC: 6.3.5.7
Q72DX1
MSALHTLSLAAIRDALARREVRAEDAVLDCLARIETTEPRIDALLHLRAEAAIEEARALDAAGPDASRPLWGVPVTVKDALTTAGTPTTAGSRILEDFVPFYDAFAVQRLREAGAIILGKNNMDEFAMGSSTENSAYKPTRNPWDTARVPGGSSGGSAASVAAGQCFASLGTDTGGSIRQPASLCGCVGLKPTYGRVSRYGLIAYGSSLDQIGPMTRTVEDAAIVMGVIAGHDKRDSTCADRPVEDFAAALASRHDLAGVRIGVPAEFWGEGLSPEVATSCRAALDAARDLGATIVDVALPHTPQSIAAYYIVASAEASSNLARYDGVRYGKRAHAPEDLMDLYVRSRSEGLGDEVQRRIMLGTYVLSSGYYDAYYRKAAQVRRRILEDYRNAFATCDVICGPVSPVTAWPLGALTADPLQMYLMDVFTLSLNLAGLPGLSLPVGLGTESGMPVGIQLLGRSFDEATLLSVGNVLSRALPPLGSPAGLR
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 51637 Sequence Length: 489 EC: 6.3.5.7
Q54L63
MNRLTNISKIRKSLIDGKLKVNDLVLNKIKEINKVSPNHLNTFISLQDEKSLGKQIKESQERYDNGTNKRLDGIPIGVKDNFSSKNFKTTCGSKILENYIPSFDSTVVKLLKEEGAIIIGKTNMDEFSMGSSSTSGHFGKVINPWSKPNNNNNNDNDNNNNGEVLYVAGGSSGGSAAAVASNYCVASIGSDTGGSIRQPSSYCGVVGFKPSYGLISRFGLVAYASSLDTPGVLTNNVEDAAELLDILIKKDQENDSTSIEFINNNQNQNQNNGEKRNILDEFNEKLKNKNIKDLVFGIPKDYLVKELDTDILNLWKEVVEEIEKRGGKVVSVSLPHTRYALPAYYLLATSEASSNLSRFDGVRYGYRFEEEKDENKVDNDNDDDDDVDENKIGMGLKDMYTKTRTNGFGEEVKKRIILGTMALSRSSYDNFYTKAQKIRRLVSDDFKNVFQGENKVDILITPTAPSPAFKQNEKMDPIEVYVNDIMTIPSNLAGLPACSIPLKLSNSNLPISVQLISNRLTDDNLLFAAHTIMNFDCYKDFTSLTPNYLK
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 61155 Sequence Length: 550 Subcellular Location: Mitochondrion EC: 6.3.5.7
Q9VE09
MRRHLQWSIKQLTASYSDGQLSPRRVTEDALQDALRWKTLNAFVRLTPEQAGQQAQDAEQRYKLRQPISDLDGVTIAIKDNFCTKDVHTTCASRMLQDFVPPYDATVCSRLKQAGAVILGKTNMDQFAMGAGTVDSLYGPTKNIWSEDLNKDHWRIAGGSSGGSASAVAAGLCYAAIGSDTGGSTRNPASYCGVVGLKPTYGLVSRHGLIPLVNSMDVPGIFARSVSDCVAVLNTVAGPDKLDSTTIRQPFTRLHLPEVGQIDLSTVRIGIPKEYHCHGLSAEVLETWSKVADLLECSGASVRQVSLPNTAASIFVYTILNQCEVASNMARYDGIEYGHRATDERSTEQLYALSRAEGFNDVVKTRILTGNFLLLKKNYDHYFEKALRVRRLIAEDFARVFDSSAKEERVDILLTPTTLTEAPLYKDFASLTNRDQCAVQDFCTQPANMAGIPAVSIPIRLSQAGLPLSLQLMSNSLNEQLLLTVARWIEAQVEFDSLEHSQQYKASL
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 55819 Sequence Length: 508 Subcellular Location: Mitochondrion EC: 6.3.5.7
Q5AQN0
MSLLLEAERYVANQSSNRMLNAFITPLCRHSGRWHDQAKDADIRGKQGKLRSRLDGRFIAFKDNICTRDFPTTCASKSLDTFTSPFNATVVQQLEDAGAIVAGKTNLDEFGMGSHSIYSSFGHVMNTRRGDDSKFLSAGGSSGGNAVAVATDQCYAALGTDTGGSIRLPAAYTGTVGFKPSYGLLSRWGVIAYANSLDTVGILAKRVSVARDVFDVLNKHDPRDPTSISPSSRSRISSKLNLPQLTSRLTSRPLRIGIPLEYNISELAPSVRQAWCHSLEYLRQQGHTIQPVSLPMTKLALSAYYVLAPAEASSNLAKYDGVRYGTRSDDSTENQSETYLYAKTRGAGFGPEVKRRIMLGAFSLSAQAIDNYFIQAQRIRRLVRHDFDAAFQAEHPLAAEIRNVELRQQAKQTGIDVLISPTAPTPPPTISDITDTSTKRSNLDAYINDVFTVPASLAGLPAISVPVSGKDNAGNQEGDILAGIQVIGQYGDDELVLKVGELLERR
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 55011 Sequence Length: 506 Subcellular Location: Mitochondrion EC: 6.3.5.7
B1GZD3
MDEILKTRVKDLCEKIRSGQIKSIEIVKACFKRIKETDPKVKAFLKLNEERSLKQAAQSDDKIKTGAECGSLEGVPIGIKDNIMIKGESMTSASKYLENYISPYDAAVIEKLKEAGVIFVGRTNMDEFAMGGSTETSVYQKTANPWNIDYIPGGSSGGSAAAVSSGMVPFALGSDTGGSIRQPAGFCGIVGYKPSYGLISRYGACALASSFDQIGVFSKTVKDASLLTSFIAVGDYRDPVCETGEQTNYAHGIYNPDILKTVRIGIPKQLSNYKADEEITKYFGDAVNKLKLEGAATVEIDVPAYKYVPALYEVIMCAEVSANIATFDGIRYGYRSSNGRNLNDEYAKSRAESLGYEVKKRILFGTYVLGAKNYYRCYHQAQRVRTLLINQITDAYKKCDFIFSPATLQMPVKFGEKLSEECDIFLTAANLAGLPGITVPCTFTSSGMPMGVHFMGSRFSDAKLFQIADAFERISGFDINKYPNL
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 53099 Sequence Length: 485 EC: 6.3.5.7
B0TWN0
MSYIKKLRARLDSGEVTAVELTKQYLAKIKDQDKSINSVITLCEAEALKEAENADAIISAGKQSLLTGIPILHKDLFCTKGIKTTAASKMLDNFVAPYDSTVTKNCKDQGMVTLGKLNMDEFAMGSTNEHSYYGAVSNPWDLDRVPGGSSGGSAAAVAAGFAPVSTGSDTGGSVRQPASFCGLTAMKPTYGSTSRFGMVAFASSFDQAGIFGHYAEDVAIMLDAISGECQYDSTCVGVKENHFTQDLEKDISGKVIGIDESLIKDLPAQIQEAVSKTLDNFKKLGAEIKSVKVPDLKEALSTYYIITPAEAAANLARYDGIRYGYRNPEARDLDELYRKSRTDGFGEEVKRRIMIGNYVLASSQYDSYYNKAQQLRKVMTDQINQIFEQVDVIFMPAAPSEAFKKGDKLDPVSAYLSDIYTIPANISGLPAIAFPIGFANDLPVGGQFMAKAFNDNVLTQMVTQYQNSYGIEEFILEQARI
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 52332 Sequence Length: 481 EC: 6.3.5.7
B2ATX1
MLSRSGLRGARLRVVSLTSQRRLLNHFITHPPEPIPPPPPPAPSSSPSPKQFTLAVKDNIATTIPGLPTTCASGILSKSYVSPIEATIITQLRARGAVITGKTNLDEFGMGSHSIYSHYGPVSQDTPPETSAGGSSGGSAVAVANGEVELALGTDTGGSVRLPAAYTGIIGYKPSYGMISRYGVIPYANSLDTVGFLSKQINPLKELIIGERGLWKEHDSNDPTSLTTAARKRCAAQRRGYRSRQGQTTELEGLKFGIPLEYNIAELDPEIRDAWAAAAKRLQDAGARIVPVSLPTTKHALAAYYVIAPAEASSNLAKYDGVRYGARDAEGASDASAGGVLYASTRGKGFGEEVKRRILLGSYTLSSEAMDNYFIKAQRVRRLVRRDFNRVFALENPLQERETFELSDLPEEVEMEDKWGPEEVDFLLCPTAPTLAPKLKGVMEQQPVDAYMNDVFTVPASLAGLPAISVPMKVATEGAAGLQLIGQYWDDARLLDVADAVAKEVRT
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 54516 Sequence Length: 507 Subcellular Location: Mitochondrion EC: 6.3.5.7
A2BWS5
MNFNSFRKEIKSGNASVKELINEFFLKIDSLDPKINAYTCLTKEIANSQSEQIDKLISNNEQLPPLAGIPIAIKDNICTKGVVTSCSSKMLQDFVSPYESTVSGKLWSSGGIFLGKTNLDEFAMGSSTETSVFGTTSNPWDTKRVPGGSSGGSAASVAAGLCAASIGSDTGGSIRQPASFCGVVGLKPTYGRVSRWGLIAFASSLDQIGPITNTVSDAAEILYSMSGKDPLDSTCLDKPVPNYLSDLDKSIKGLKIGIIEECFNHPGLDQEVKLSVLSAVDRLKSLGAEIHDVKCPRFNDGIATYYVIAPCEASANLARYDGVKYGYRSDGDTNLVEMISKSRAEGFGNEVQRRILIGTYALSAGYSDAYYKKAQRVRTLIRKDFDSAFDKVDVLLTPTCPTTAFLKGDFINDPLSMYLSDLLTVPANLAGLPAISIPCGFDKKGLPIGLQLIGNVLEEHRILNVANIFEKDADVMKRKPSIEI
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 52120 Sequence Length: 484 EC: 6.3.5.7
Q2IH95
MPISDFQVVIGLEVHAQLLTASKIFCGCSTAFGGAPNAHTCPVCLGLPGALPALNRSVVEMAVRTGLALGCEIRPKSVFARKNYFYPDLPKGYQISQYELPICEGGEVTFTLDGRDHTARLVRIHMEEDAGKNVHDVAADGSSGVDLNRAGVPLVEIVSRPDLRSAEEAVEYLKALRAILMALGVNDGNMQEGSLRCDANVSVMRKGASELGTRCEIKNMNSFRFLKQAIEFEARRQVELIEAGEPVVQETRLFDPDRGETRSMRSKEEAHDYRYFPEPDLPPVIVEAALVERLRGELPELPRAKAERYQRSLGLSAQDAGNLVADAAVSAWFDAAVAAYGAGPEAAKKVANWVIGELARLANETGEAPAAWKLTPARLAAVLRLIDAGTIGGPGAKQVVEEVFRTGAEPDAVVKAKGLAQVSDEGAIEAAVDKVLAANPGEVEKYRGGRKNLVGFFVGQVMKEMRGKGNPAVVNALLRRKLGD
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 52068 Sequence Length: 484 EC: 6.3.5.-
O66766
MNEKYEAVIGLEIHVQMDTKTKMFCGCKVEFGAEPNTNVCPVCLGMPGALPIVNKRAVEYAIRASLALNCEVHEESVFARKHYFYPDLPKGYQISQYEKPLATNGWVELNLPNGEKKKVRIRRLHIEEDAGKNIHEGDKTLVDLNRAGTPLMEIVTEPDIRTPEEARLFLEKLRNIMRYAGVSKADMEKGQLRCDINVSIRPKGSKEFGTRVEIKNVNSFRFVQKALEYEIERQINVVEEGGEVVQETRTFDPQTGKTYPMRTKEEAEDYRYFPDPDLVPLKVKKEWIEEIKKNMPELPDQRFERLIKEYGLSEYEAGILVNHKEVGDFFEEAVRHFKEPKGIVNWLINDLLGLLRDKGISIEESPVKPEHLAELVKLIKEKVISTKIGKEVIKEMVETGKTPSQIVEEKGLKQITDENQIKELVKKIFEKHPKEVERLKQGEEKLIGFFVGQVMRETRGKANPQVVNKVIRELVKEV
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 55041 Sequence Length: 478 EC: 6.3.5.-
Q9FV81
MSTTLLRTIQLNQFSLLGTSLLRRRRSNNFSVRSCGSQTTTTHEAKQSSPTRVAPKNHKSNQLDEILRDYEAVIGIETHVQLSTLTKAFCSCSNNYGSYPNTSICPVCMGLPGALPVLNSKVVEFGVRLGLALNCDLSLKSKFDRKQYFYPDLPKGYQISQFDIPIASGGYVDVDIPLEFGGGHRRFGITRVHMEEDAGKLLHSDTGDYSQVDLNRAGVPLLEIVSEPDMRSGIEAAEYACEMQRIARYLGVSNGNMQEGSLRCDVNISIRPIGQAEFGTKVEIKNLNAFSAISRAIDFEISRQALLYNQGKADQIVTETRLWEEGAQKTVTMRKKEGLADYRYFPEPDLPEVILTQEYVDSIRASLPELPEAKRRRYEAMGLGMQDVLFLANDVSVAEYFDAVIGKGAEVKLAANWIMSDIAAYLKNEKLSINDIKLTPQELAELIAAIKDGTISGKIGKEILFELLAKGGTVKGMIKAKDLVQITDPAEIEKMVIQVVSENPKQLEQYRSGKTKLQGYFAGQVMKMSKGKANPGLLNKILLEKLNAKD
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 60941 Sequence Length: 550 Subcellular Location: Mitochondrion EC: 6.3.5.-
O28164
MDDVVIGLEVHVQLNRLRTKLFCSCPLNYHQSPPNTHVCPVCLGMPGAMPVINKEAVKAAVKVAMALNAEIQPFTVFDRKNYFYPDLPKGFQISQYDRPLALGGYVTIELDGQEKRIQLKRVHMEEDPGKLSYKGSITTAKYSLIDYNRSGAPLLEIVTEPVMNSPKEARLFLNKLRMILEYLEVFDGDLEGAMRVDANISIRGSGRVEIKNISSFKGVEKALSYEIMRQKNLLQRGRSVVRETRHFDEARNITVSLRSKEEEQDYRYFPEPDLVPVLTEEIVREVEGTLPEMPEEKRERLKRQYGIGDNFAKVLILDVKMADYFEEVAKLVDPKLAASWIVDVLRGELNYRDWSFAKCWEVFKPEEFAKLLKYFEEDRITEKGVVEVIRTKLDEGGEIDAIIQKKGLFAIPKEEIIKFCKEAIEENPKAVEDYLSGKRQALNFLVGQVMKKTRGRADPADTAKLIEEMLS
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 53922 Sequence Length: 471 EC: 6.3.5.-
Q5P4D1
MSRNDWEVVIGLEVHAQLNTASKIFSAASTAFGAEPNVQASAVDIALPGVLPVLNGGAVERAIRFGVAIGATVAPKSVFARKNYFYPDLPKGYQISQFELPVVQGGAITIRVGDGDKAYEKTVQLTRAHLEEDAGKSLHEDFHGMSGIDLNRAGTPLLEIVSEPDMRSSAEAVAYARALHALVRWIDICDGNMQEGSFRCDANVSVRRPGGPLGTRREIKNLNSFRFLQQAIDFEVQWQIGTIEDGGRIQQATVLFDPDTGETRMMRSKEDAHDYRYFPDPDLLPLVIPSEWIARVRSEMPELPGAMKARFINDYGLSAYDAASLTAAKEIAAYYQAMLATADTKPGSQVPKLGANWVMGELAAQLNRAERDIGDSPVTPAQLAGLVQRIADGTISNNIARKVFAALWNGEGGSGADAADRIIEAQGLRQVNDSSALEPLIDEVLAANRKSVDEFRAGKEKAFNALVGQVMKASRGKANPAQVNEMLKRKLDA
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 53422 Sequence Length: 493 EC: 6.3.5.-
P61343
MNYQAVIGLEVHVQLKTDTKIFCGCSTTFGASPNSQTCPVCLGMPGVLPVLNKKVVEFAIRAGLATNCRIAPRSVFARKNYFYPDLPKGYQISQYELPICQNGHLDIEVDGQVKRIGITRIHMEEDAGKLVHADVPGLGSGSGVDLNRACTPLLEIVSEPDIRSADEAVAYLRKLHQIVVYLGICDGNMEEGSFRCDANVSVMPVGSTTFGTRTETKNVNSFRFVKQAIEHEIERQIELIEEGGKVVQETRLFDPNTGETRSMRGKEEAHDYRYFPDPDLVPLVISNDWVEDTRLSLPELPDARRSRYRSELGLSDYDAEVLTATREMAEYFENCLAAGAPAKGAANWVMGEVTRALNEAGKDIAECPVAPARLTALLQLIEKGTISGKIAKTVFDEMWQSDKAPEAIVEEKGLVQVSDTGAIEKIIDEIMAANMGQVEEFRGGKEKVFGFFVGQVMRASKGKANPAVVNELLMKKLKG
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 52668 Sequence Length: 479 EC: 6.3.5.-
Q7NI42
MTSTAPPKVQYEAVIGLEVHVQLSTETKLFCRCSTRFGNTPNTNICPICTGQPGTLPVLNQQALDYAVLTASALNCQIHPQGLSKFDRKQYFYPDLPKNYQISQYDLPLAERGWLEIEVEGEPAKRIGITRLHMEEDAGKLVHAGADRLSGSTHSLVDFNRAGVALCEIVSEPDIRTAAEAAAYAGELRRIVRYLGVCDGNMQEGSLRFDLNISVRPAGEGKFGTKVEIKNLNSFNSLQRAVEYEFARQVDCLLSGERIVQETRLWDEATQRTISMRSKEEANDYRYFPEPDLVPIALNGTQIDAYRQRLGELPAQKRHRYRETLGLSSYDAGVLTDEREVAEYFEQVVALGIPAKQAANFVSGAVAAHLNETRRSISQIKVTPEVSAELLALINQGIISNRIANELLPDLFEKGGSPRALVEERGLTQISDRGQLEQIVDEVLAGESDSVAAYRGGRTKLLGFFVGKVMKKTAGRADPQVVNDLLQSKLAEQPTAPPPEPESAAETPEAPPAVEDAPPEAPTEAITAEAGSAEAITAASEEPDTPVSHQDAHA
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 60533 Sequence Length: 554 EC: 6.3.5.-
Q9HS93
MSAQAAERDLTAIIGLEVHVQLETDTKIFCGCSTDTDDADPNTHTCPVCLGLPGALPTLNEGAVEAAVKLGKAIDADIPERTRFHRKNYFYPDLPKGFQITQYDAPICQDGELEVGTADDRRAIGIERAHLEEDPGSLQHVGGSIEDADYTLVDYNRAGTPLMEIVTRPDFRAAEEVRSFLAKLTSVLEYLGVFDAERDGSLRVDANISMVDSAELAGEGGPSDDVLEAANRTEVKNISSHRAAQKALAYETTRQRNQLERGMAVAQETRHWDEARGVTVSMRSKEEEKDYRYFREADIPPLEVSDWKDEIPIPELPDARRERFRTEYGVGDETASKLTSRKAVADLFEELADEYDAALAATWVADNVLGELNYRDLSLDDVADRDDEFERLVELVAEDEITAKNAEEVVLRTMLDEDRAPDEIVDAEGLGKTSGDAVADAVAEAIAENPDAVADYHDGEGDALNFLVGQVMAKTGGSADPGQVNELLRDELAQA
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 54267 Sequence Length: 495 EC: 6.3.5.-
O06492
MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNEVNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10859 Sequence Length: 96 EC: 6.3.5.-
Q6FZS8
MSVDQETVKRVSHLARIAIHDDEIEPMTKELNVILGFVEQLNEVDVNGIEPLTSVMPMALRMREDSVTDGDKVADIVANAPVTEENFFLVSKVVE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10580 Sequence Length: 95 EC: 6.3.5.-
Q1DCA4
MALTLEQVRHVATLARLSLTPEEEQRFTTQLSAVLDAVEQLQSLDVEAVEPTSHATLTSSRLREDVTRPSLPPEKSLANAPAKSDTSFAVPKIIE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10380 Sequence Length: 95 EC: 6.3.5.-
B2A5W6
MKVSKEEVLHVAKLGQLDLDQEEVEMFQDKLSQILEWQEKLDELDLEGLEPTAHALERRNVTREDQVHNSLTNDKALENAPETEGNYFKVPRIIE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 11056 Sequence Length: 95 EC: 6.3.5.-
B9LA82
MKIDESLVKRLETLSMVEIEDKASMAKDLAEIVEFVEMLNELDTSNVDATFSTLDNSTYLREDEPIKNNVIEEILEHAPKAKDGFFIVPKIIE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10602 Sequence Length: 93 EC: 6.3.5.-
Q9JZ00
MALTLADVDKIARLSRLHLTAEEKEKSLQELNDIFTMVEQMQTINTDGIEPMAHPHEAALRLREDEVTETDRAAEYQAGAPEVRNRLYIVPQVIEE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10958 Sequence Length: 96 EC: 6.3.5.-
Q2YC92
MSLSLDDVKRVANLARIEISEDEARKALIQLSGIFGLIEQMQAVDVSAITPMSHAQDVMQRLRADGATEIDQRELFQSVAPQVEAGLYLVPKVIE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10479 Sequence Length: 95 EC: 6.3.5.-
Q5YRT3
MPAISRDEVAHLARLSRLALSDAELDQFAGQLDSILSHVRTISEVAAADVPATASPDPVTNVTRPDTVVPGLTPDQALAAAPAVEEQRFMVPQILGEGE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10397 Sequence Length: 99 EC: 6.3.5.-
Q4RSW7
MSVLRFATRRGLSWCYASRLTHQGTSVTSGEGSPGTRTSRVPARVLNLTRPLSCRAYNSKVPQSPTWEPVSEDLLPPCAQFPADLVDKLERLALVDFRTKQGLECLEKAIRFADQLHVVDTSGVEPMDSVLEDRVLYLREDEEKEGDCAEELLQLSRNTCEEYYVAPPGNIPLPTREKRAAMLKHSEF
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 21152 Sequence Length: 188 Subcellular Location: Mitochondrion EC: 6.3.5.-
Q47SC4
MSAITRDEVAHLARLARLALPEDELDQLAAQLDVIISAVAKVQEVAKGDIPPTSHALPLTNVYRPDEVKPGLTPDQALAEAPAVEDGRFRVPQILGEEG
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10600 Sequence Length: 99 EC: 6.3.5.-
Q9WY94
MIKVTKDLVLHLENLARLELSEDQRESLMKDFQEILDYVELLNEVDVEGVEPMYTPVEDSAKLRKGDPRFFEMRDLIKKNFPEEKDGHIKVPGIHR
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 11309 Sequence Length: 96 EC: 6.3.5.-
B9L146
MRLSREIVDHVAMLARLGLTEEERELMREQLSSILEHVSRIQELDTEAIPPTAQVITLQNVWREDDVRPSLPVEAVLANAPESEDGFFRVHAVLEQS
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 11059 Sequence Length: 97 EC: 6.3.5.-
Q9LCX4
MELSPELLRKLETLAKIRLSPEEEALLLQDLKRILDFVDALPRVEEGGAEEALGRLREDEPRPSLPQAEALALAPEAEDGFFRVPPVLE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 9957 Sequence Length: 89 EC: 6.3.5.-
O83982
MAQQRITSDIFAQLLTLSHLESSECAVGLATQIEDIIQYFSVVEQFDPGPRDDPDTDNAQGRCSQGNKIDVDCCPDWVRKDVALPGLSVHDLKRLSTEFADGYFRAPRALDGSA
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 12559 Sequence Length: 114 EC: 6.3.5.-
B3RYZ0
MAVKPSANLGKAFQLPHPFNSCVYIQIPPQPTWSINEYWERNPNKQYLDESDTTYLEELTLTPIEKHQALEKLNTIISAADRLQEVDTKNVDPMYTCVDEREMYMNSGQDGETVNKEEILGNAHKIFQDYFTAPTSEKMRSSSDLNAKE
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 17121 Sequence Length: 149 Subcellular Location: Mitochondrion EC: 6.3.5.-
A5CX64
MSLSENQVSQIAHLACLSLNEAQLKDNTQNLNTITSLFEQLANIEIDGVEPMLHPLHMFQRLREDVVSEKEQLALFQSIAPKVRNGYYLVPTVIK
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10777 Sequence Length: 95 EC: 6.3.5.-
D7STK2
MGSRALLLLKATTAETLLFTSKSTFSKALIRNSTRSFSTRSALLPPDLPRLAETARISLTPHEVEEFAPKIRQVIDWFGQLQAVDLQSIEPSIRADTEGDNLRDDSPETFENREAIIAAIPSYEEPYLKVPKVLNKD
Function: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 15328 Sequence Length: 137 Subcellular Location: Mitochondrion EC: 6.3.5.-
Q7MSD5
MQIDDKLLARLESLAMIEVPEEKKESIKAELGEIVNFVENLNSLEVEGLEATFTTLEGKTPMREDTPMNDEEIPALILKHAPQSAENYFIVPKIIE
Function: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln). Catalytic Activity: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate Sequence Mass (Da): 10840 Sequence Length: 96 EC: 6.3.5.-
Q9CXP8
MSSGASVSALQRLVEQLKLEAGVERIKVSQAAAELQQYCIQNACKDALLLGVPAGSNPFREPRSCALL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 7229 Sequence Length: 68 Subcellular Location: Cell membrane
Q5E9F0
MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSREDPLVKGIPEDKNPFKEKGSCIIS
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8594 Sequence Length: 73 Subcellular Location: Cell membrane
P61952
MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCVIS
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8481 Sequence Length: 73 Subcellular Location: Cell membrane
Q28024
MSSKTASTNNIAQARRTVQQLRMEASIERIKVSKASADLMSYCEEHARNDPLLMGIPTSENPFKDKKTCTIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. PTM: It is not sure whether phosphorylation by PKC is on Ser-2 or Ser-3. Location Topology: Lipid-anchor Sequence Mass (Da): 8057 Sequence Length: 72 Subcellular Location: Cell membrane
Q9UBI6
MSSKTASTNNIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLIGIPTSENPFKDKKTCIIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8006 Sequence Length: 72 Subcellular Location: Cell membrane
Q9DAS9
MSSKTASTNSIAQARRTVQQLRLEASIERIKVSKASADLMSYCEEHARSDPLLMGIPTSENPFKDKKTCIIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 7997 Sequence Length: 72 Subcellular Location: Cell membrane
Q9P2W3
MEEWDVPQMKKEVESLKYQLAFQREMASKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKGKCTIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 7949 Sequence Length: 67 Subcellular Location: Cell membrane
Q9JMF3
MEEWDVPQMKKEVESLKYQLAFKREMSSKTIPELLKWIEDGIPKDPFLNPDLMKNNPWVEKAKCTIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 7979 Sequence Length: 67 Subcellular Location: Cell membrane
P02698
MPVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEFRDYVEERSGEDPLVKGIPEDKNPFKELKGGCVIS
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8544 Sequence Length: 74 Subcellular Location: Cell membrane
P38040
MDVMSSSLQQQRVVVEQLRREAAIDRQTISESCAKMMKYITEHEQEDYLLTGFTSQKVNPFREKSSCTVL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8130 Sequence Length: 70 Subcellular Location: Cell membrane
Q61012
MPVINIEDLTEKDKLKMEVDQLKKEVTLERMMVSKCCEEVRDYIEERSGEDPLVKGIPEDKNPFKELKGGCVIS
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Location Topology: Lipid-anchor Sequence Mass (Da): 8528 Sequence Length: 74 Subcellular Location: Cell membrane
P59768
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 7850 Sequence Length: 71 Subcellular Location: Cell membrane
Q9BY60
MKFQYKEVHPFEYRKKEGEKIRKKYPDRVPLIVEKAPKARVPDLDRRKYLVPSDLTDGQFYLLIRKRIHLRPEDALFFFVNNTIPPTSATMGQLYEDSHEEDDFLYVAYSNESVYGK
Function: Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). PTM: The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL3-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes (By similarity). Location Topology: Lipid-anchor Sequence Mass (Da): 13976 Sequence Length: 117 Subcellular Location: Cytoplasm
O00591
MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 50640 Sequence Length: 440 Subcellular Location: Postsynaptic cell membrane
P24046
MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 55883 Sequence Length: 479 Subcellular Location: Postsynaptic cell membrane
P56476
MPYLMRLALVLFCLMALVESRKPRRKRWTGLLETSKPSHLYKKNLDVTKMRPGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWRDERLAFPSSSNKSMTFDGRLVKKIWVPDVFFVHSKRSFIHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVFVFLSVLEYAAVNYLTTLQEQKERKFREKLPCMCGMLHSRTMMLDGSYSESEANSLAGYPRSHILPEEERPDNIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFPAFYIVFNLIYWSVFS
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission (By similarity). Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54231 Sequence Length: 465 Subcellular Location: Postsynaptic cell membrane
P47742
MPYFMRLALFLFCLMALVESRKPRRKRWTGHLETSKPSHLYKKNLDVTKIRTGKPRPLLRVEDHDFTMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWRDERLAFPSSSNRSMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDHRAVPARVSLGIMTVLTMSTIITGVNASMPRVSYIRAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQEQKERKLRDKFPCTCGMLHSRTMTLDGSYSESEANSLAGYPRSHILPEEERQDKIVVHLALNSELTSSRKKGLLKGQMGLYIFQNTHAIDKYSRLIFPAFYIVFNLIYWSVFS
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54296 Sequence Length: 465 Subcellular Location: Postsynaptic cell membrane
P50573
MVLAFWLAFFTYTWITLMLDASAVKEPHQQCLSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFIEEFSASSGLAFYSSTGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQTSFFLHSEEDSMRTKFTGSPCADSSQIKRKSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLFYWGIYV
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 54031 Sequence Length: 464 Subcellular Location: Postsynaptic cell membrane
Q9UN88
MGIRGMLRAAVILLLIRTWLAEGNYPSPIPKFHFEFSSAVPEVVLNLFNCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRRPRRVIARYRYQQVVVGNVQDGLINVEDGVSSLPITPAQAPLASPESLGSLTSTSEQAQLATSESLSPLTSLSGQAPLATGESLSDLPSTSEQARHSYGVRFNGFQADDSIIPTEIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDKSDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVPKVDKWSRFLFPLAFGLFNIVYWVYHMY
Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Location Topology: Multi-pass membrane protein Sequence Mass (Da): 71988 Sequence Length: 632 Subcellular Location: Postsynaptic cell membrane
P71016
MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIKAIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKADMDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWKIAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNKDVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVFFHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKVEKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTVETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPWGGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS
Function: Involved in the biosynthesis of the osmoprotectant glycine betaine from choline . Catalyzes the oxidation of betaine aldehyde to betaine . Shows specificity for betaine aldehyde as substrate. Can use both NAD(+) and NADP(+), but NAD(+) is strongly preferred . Catalytic Activity: betaine aldehyde + H2O + NAD(+) = glycine betaine + 2 H(+) + NADH Sequence Mass (Da): 53666 Sequence Length: 490 Pathway: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. EC: 1.2.1.8
P71017
MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKALLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGLVAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVTQWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTMKFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAHAMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAKASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYKRCFNLTPKTV
Function: Involved in the biosynthesis of the osmoprotectant glycine betaine from choline. Catalytic Activity: choline + NAD(+) = betaine aldehyde + H(+) + NADH Sequence Mass (Da): 43421 Sequence Length: 402 Pathway: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (dehydrogenase route): step 1/1. EC: 1.1.1.-
A3DHH6
MIDKERIKAAVRELLIGIGEDPDREGLLETPDRVARMCEEIFAGLHQDPKSVVKVFQEENHEEMVMVKDIPIYSICEHHLLPFIGVAHVVYIPRKGKIMGLSKLARIVDIIARKPQLQERLGSEVANVIMESINPLGVAVVVEAEHLCMTMRGIKKAGSKTVTSALRGIIKTDARTRAEVMALINGR
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 20811 Sequence Length: 187 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
P30793
MEKGPVRAPAEKPRGARCSNGFPERDPPRPGPSRPAEKPPRPEAKSAQPADGWKGERPRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
Function: Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown. PTM: Phosphorylated by casein kinase II at Ser-81 in HAECs during oscillatory shear stress; phosphorylation at Ser-81 results in increased enzyme activity. Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 27903 Sequence Length: 250 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. Subcellular Location: Cytoplasm EC: 3.5.4.16
A2BL58
MPIDKAKIEKAVRMILEAIGEDPEREGLRETPRRVADMFEELLEGYDFTEEYTWFTEATDLVVVSGIRFYSLCEHHLLPFFGVAHVAYLPRGKVIGLSKIVRIVNKYSRRLQIQERMTKQIADEISKATGSPDVMVITEAVHLCMAMRGVRNGAPTVVAAVRGEFERDQSLKEEVYRIIEPHRLSRVIALSFF
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 22099 Sequence Length: 193 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
Q0BXB5
MDAVTPKKDIPRPDSVRRPSQQEAEEAVRTLIAWAGDDPAREGLIDTPKRVVNAYKEWFEGYGEDPVKYLSRTFEDVQGYDDIVMLRNIEVESHCEHHIAPFIGKAFIAYKPSTAVVGISKLARVVEIFAKRLQTQETMTAQICDAITESLAPMGTAVFIEAEHQCMSTRGVHHKHVTTITTQFTGVFKSDADLRNRFLNMCGQTV
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 23141 Sequence Length: 206 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
A6SZ52
MKQPIHTDPAKPDDFSTEDWRRLLTHLGENADRQGLRETPQRVEKAWKHWTSGYDQDPAEILKVFEDGAEQYNELIVVRGIPVYSHCEHHLAPFFGTATIGYTPNGKIVGLSKLTRLVDCFAKRLQVQERLTIQIADTLMEHVQPLSVGVVIRCRHMCMESRGIRTPGEETVTSALLGEMRTNLGLRNEFLMLAREKD
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 22608 Sequence Length: 198 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
Q88ST4
MIDEKNQAKIEHAVREILSAVGEDPDRPGLVETPARVARMYAEVFATKTAAPFDNYKLFKVEHPTEMVLLKDIPFYSMCEHHLLPFFGTVQVAYVPQHEQVIGLSKIPRLIDYCSQQPNVQERLTVSIATELQRILDPAGIAVSITARHMCMEMRGVSKPGVHTESSYYSGQFKTDLDLKREFLQRIAK
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 21461 Sequence Length: 189 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
Q38WN0
MIEQANQQIEKDVRDILKQVGDDPERAGVLETPQRVAKMYGEVLAYQGETIFKDYKLFETEETDDDQMVMMQDIPFYSMCEHHMLPFFGQVSVAYLPANGQIIGLSKIPRLVDFVSKRLSVQENLTRDIGQILNQILKPYGVAVQVTARHMCVEMRGIKKANSQTHTTFYSGNFKTDRQLRSEFLQLLK
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 21753 Sequence Length: 189 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
Q6ACQ1
MTGFDRARIEAAVAEILAAVGEDPSRPGLSATPSRVADAYAEFFAGLGRDAEAELGEPVPLEQGQAETVILREISFRSVCEHHLLPFIGVAHVAYLPGEAVIGLGRIPRVIDTLAARPQVQERLTEQIADTFEAGAGARGVLVVLSAEHGCVTARGPRQVAATTVTLAARGEFAEPAARAELIALIGCGAA
Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 19874 Sequence Length: 191 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
Q2T7N4
MNLMNPEFVMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEESGGPLTADAFRAMLATMLEKLEAQAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRRA
Function: Converts GTP to 7,8-dihydroneopterin triphosphate. Catalytic Activity: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) Sequence Mass (Da): 30188 Sequence Length: 269 Pathway: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. EC: 3.5.4.16
B1W019
MSQITLPAFHMPFQSAGCHPGLAETREAAWEWAAAEGLDLSVPARRKMIRTRPELWISLIFPQATQAHLDLFCQWLFWAFLVDDEFDDGPAGRDPLMCERAIARLVDVFDGAAPNGPMERALAGLRDRTCRGRSPQWNRQFRRDTAAWLWTYYAEAVERAAGQVPSRAEFAKHRRDSVAMQPFLCLHEITAGIDLPDSARSLPAYIALRNAVTDHSGLCNDICSFEKEAALGYEHNAVRLIQRDRGSTLQEAVDEAGIQLARIAERVQRAERELIEEIEAAGIDGPTRTALERCVRDYRGLVRGDFDYHARAERYTRPDLVELDERDSLSRHFAA
Cofactor: Binds 3 Mg(2+) ions per subunit. To a lesser extent, can also use Mn(2+) instead of Mg(2+). Cannot use Fe(2+), Co(2+), Zn(2+), Ni(2+), or Cu(2+). Function: Sesquiterpene cyclase that first catalyzes the cyclization of farnesyl diphosphate (FPP) to the bicyclic sesquiterpene (+)-beta-caryophyllene intermediate, and then its conversion to (+)-caryolan-1-ol via a second cyclization and the addition of a water molecule. Catalytic Activity: (2E,6E)-farnesyl diphosphate = (+)-(E)-beta-caryophyllene + diphosphate Sequence Mass (Da): 37906 Sequence Length: 335 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. EC: 4.2.1.138
P0DPQ8
MTFAVSVGGRRVDCEPGQTLLEAFLRGGVWMPNSCNQGTCGTCKLQVLSGEVDHGGAPEDTLSAEERASGLALACQARPLADTEVRSTADAGRVTHPLRDLTATVLEVADIARDTRRVLLGLAEPLAFEAGQYVELVVPGSGARRQYSLANTADEDKVLELHVRRVPGGVATDGWLFDGLAAGDRVEATGPLGDFHLPPPDEDDGGPMVLIGGGTGLAPLVGIARTALARHPSREVLLYHGVRGAADLYDLGRFAEIAEEHPGFRFVPVLSDEPDPAYRGGFPTDAFVEDVPSGRGWSGWLCGPPAMVEAGVKAFKRRRMSPRRIHREKFTPAS
Cofactor: Binds 1 FAD per subunit. Function: Part of a two-component P450 system that efficiently O-demethylates diverse aromatic substrates such as guaiacol and a wide variety of lignin-derived monomers. Is likely involved in lignin degradation, allowing Amycolatopsis sp. ATCC 39116 to catabolize plant biomass. GcoB transfers electrons from NADH to the cytochrome P450 subunit GcoA. Highly prefers NADH over NADPH as the electron donor. Catalytic Activity: NADH + 2 oxidized [cytochrome P450] = H(+) + NAD(+) + 2 reduced [cytochrome P450] Sequence Mass (Da): 35566 Sequence Length: 334 Domain: GcoB has an unusual three-domain structure, with an N-terminal 2Fe-2S domain and a C-terminal region that consists of an FAD-binding domain followed by an NADH-binding domain. Pathway: Aromatic compound metabolism. EC: 1.6.2.-
D4B1R0
MIVKSLSLLALAAATVEGCVRERDVGSVDILSVLSKRGHGHPHLPHLSKYESMLINSFDNTTVDSWAYYYTHGIHIAGTNQSMAQWTADKWTEFGIPSSLVSYDVYLNYPVSHSLSLTHPDGTTWEASLVEDVLKEDDTTSYPDRIPTFHGYSASGEATAEYVYVGRGQKVDFERLIQLGVDLKGKIAIARYGGPFRGLKVKNAQDQGMIGCIIFTDPADDGNVTVANGLKAYPNGPARNPSAVQRGSVQFLSMFPGDPTTPGYPSRPDSPRKDKSPVVPKIPSIPISQLDAQPILAALDGHGTPGKEVNRTRWVGALNATYATGPAPGAKLSMSNVMRDTYTPIWNSIGIINGTEQDEVVIIGNHRDAWIIGGAGDPNSGSSIMVELAKAFGKLQKAGWKPKRTIVMCSWDAEEYGLVGSTEWVEEYLPWLKASAVAYLNIDVAVSGPVPDLSATPELHKLALESMKKVIWPYKGRQDTTMYDVWNTASGGEVGVLGSGSDYTAFVHNGIASLDTGAGGDGNTDPVYHYHSNYDSYHWMATYGDPGFHTHVAMGQFLGLLGYHLATDDIIPFDVTNYGVQMTKYLDVLKKYIAASKFPDLDVSKIESAICSFNVSANAVAKLQKKAEHNVHDQQLRKHLNTIYRDFGRGFVSQGGLPDREFYRHMLYAPGLDTGYAPTTFPGVTESLDAGNRTRAVEYIERASNAIYVAAGILSSCHDCNQFVAQE
Cofactor: Binds 2 Zn(2+) ions per subunit. Required for NAALADase activity. Function: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (By similarity). Also exhibits a dipeptidyl-peptidase IV type activity (By similarity). Catalytic Activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. Sequence Mass (Da): 79197 Sequence Length: 727 Subcellular Location: Secreted EC: 3.4.17.21
Q9M1S8
MSQPLTTRPTVTGISIIPFRQPPPLCSFLFVIVLFVATFYTLHHPDAVTPPLLFSRNAYNALRLRRLFLSSASNATISSYLRELTRHPHLAGTKPSLDTLHYVFNHFQSLGLETHVAEYEALLSYPTHISVTASFSNTTTLEFDLNDVPGDSPVVRPYHAYSPSGSAQGNVVFVNHGEERDYHALESIGVSVKGCVVLARKGENLGRGAIVKIAEAKGALGVLIYAENDGGGFGGIERGTVMRGIGDPVSPGWPGVVGGEKLSLDDELVTRRFPKIPSLPLSLRNAEIILASLGGARAPLEWRNSGRVGPGQRVGPGRMVINMTFQGEMKMKKINNVVVTIRGSEEADRYVILGNHRDAWTYGAVDPNSGTSALLDISRRFALLLKSGWRPRRTILLCSWDAEEFGMIGSTEWIEENVLNLGASAVAYLNVDCAVQGSGFFAGATPQLDGLLVDVLKLVQDPDAVGLTVEETFKSQNNIIQRLSRVDSDFSGFLHHAGIPSIDMYYGADYPVYHTAFDSYDWMIHNADPLFHRHVAMAGIWGLLGILLADEPLIPFDYISYADQLQAHRDKLSKLLEGKVSVNPLSMAIQEFSLVAKEAADEAKKLKGKSYSKNDVAAAAKRRELNDRLMLVERGFLDAEGIKGKEWFKHLVYGPAAEPESKLGFFPGIADAIAMNASEGIIEHEIWRVARAIQRASKALKGGFT
Cofactor: Binds 2 Zn(2+) ions per subunit. Function: May modulate the level of one or more small signaling molecules that have a role in regulating meristem function. May play a role in balancing and restricting the meristem-promoting activity of auxin signaling . Involved in ethylene and giberellin (GA) signaling pathways or in a parallel pathway controlling cell and hypocotyl elongation and cellular organization . Involved in abscisic acid (ABA) signaling pathway. Plays a negative role in ABA-mediated seed germination and seedling development . Acts in association with LAMP1 to suppress ectopic stem cell niche formation in the shoot apical meristem (SAM) independently of cytokinin signaling pathway . Modulates responses to ABA, oxidative stress and abotic stress . Acts as negative regulator of the ABA signaling pathway to modulate freezing and drought stress responses. Mediates carbon and amino acid metabolism . May be involved in the acquisition and/or maintenance of seed dormancy . Involved in the regulation of response to heat shock and plant defense . Catalytic Activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 77153 Sequence Length: 705 Subcellular Location: Endoplasmic reticulum membrane EC: 3.4.17.21
P91406
MPYVGVGAQTVSTSLTGAPMVKAYIAIAASLIFVFCIAALGVHHSERKFNKFNKVSIDDIHKSDAGVIQDNIKTENIKKYLRIFTKDPHVAGTEANKKVAYEIANAWSEAGLEDVHTLPYEVLLSYPDFENPNSVIIKSSAGKEVFKSKGVSPVIIPDEQSGKYAGHQWLAYAGNGSASADVVYINHGTANDFKNLKLMGVDIKGKIALMRYGHGFRGDKIHKAQQAGAIGAILFSDTQDVAQDGVESENVYPKKIWMPNEGVQRGSLMHGDGDALSPYYPSKKELFKGRTIEEAKEDGVLPSIPVLPVSYTTGYEILKRLSGRPAPSDWQGFVGGNLTYKLGPGFVNGEKLSINVHSELRTKRIRNVIGYIRGSEEPDSYIMLGNHFDAWVYGSIDPNSGTAVLAEVARAMMQTINETSWKPARTIVFNAWDAEEFGLIGSTEFVEEFVNILQKRAVVYINMDCIQGNISLHVDTVPILEHAVIEASKQVENPSKRERSRGRKTLYDTWMKVFPDKKAGVPKIRVPGGGSDHAPFLNFAGVPVINFTFKNYTTWDTYPLYHTMYETPFSNIHLLDTDNLSVHKAIGQYWAELAKTFADDVILPMNTTHFASVMLKTYLPQLKTTISGINVSRSDFEDIRTQYALLSKSAQDLLTMSKKFQETIHFTQHSFSQNPYDPKHVNAVNERLKSTERCFINPRGVSMHNPSARHVLFSVSDSDSYSSSLMAGVQNAINSYDLNPTKKGLREIINQISIVQYSVICVVNTLRDVI
Cofactor: Binds 2 Zn(2+) ions per subunit. Catalytic Activity: Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. Location Topology: Single-pass type II membrane protein Sequence Mass (Da): 85501 Sequence Length: 770 Subcellular Location: Membrane EC: 3.4.17.21
P20821
MALRAVRSVRAAVGGLRAISAPSAPCLPRPWGLRAGAVRELRTGPALLSVRKFTEKHEWVTTENGVGTVGISNFAQEALGDVVYCSLPEVGTKLNKQEEFGALESVKAASELYSPLSGEVTEINKALAENPGLVNKSCYEDGWLIKMTFSNPSELDELMSEEAYEKYIKSIEE
Cofactor: Binds 1 lipoyl cofactor covalently. Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Sequence Mass (Da): 18791 Sequence Length: 173 Subcellular Location: Mitochondrion
A2Z9B8
MALRLWASSAANALKISCSGATRAAPAYSISRYFSTVLDGLKYSSSHEWVKNDGSVATIGITDHAQGHLGEVVFVELPEAGAKVSQGGAFGNVESVKATSDINSPISGEVVEVNDKLSETPGLINSSPYEDGWMIKVKPSSPSELDALLDPAKYTKHCEEEDAH
Cofactor: Binds 1 lipoyl cofactor covalently. Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity). Sequence Mass (Da): 17367 Sequence Length: 164 Subcellular Location: Mitochondrion
P16048
MALRMWASSTANALKLSSSSRLHLSPTFSISRCFSNVLDGLKYAPSHEWVKHEGSVATIGITDHAQDHLGEVVFVELPEPGVSVTKGKGFGAVESVKATSDVNSPISGEVIEVNTGLTGKPGLINSSPYEDGWMIKIKPTSPDELESLLGAKEYTKFCEEEDAAH
Cofactor: Binds 1 lipoyl cofactor covalently. Function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Sequence Mass (Da): 17688 Sequence Length: 165 Subcellular Location: Mitochondrion
Q9I137
MTDNLNLGAIDLGTDDEFIARHIGPRAADTQAMLQRLGYDSLDTLIGNVIPDSIKGSSVLDLPAGMGEAEALASLKAIAARNRALRSFIGQGYYNCHTPAPILRNLLENPAWYTAYTPYQPEISQGRLEALLNFQTLVSDLSGLPIANASMLDEATAAAEAMTFCKRLSKNRTSQAFFASRHCHPQTLDVLRTRAEPLGIEVVVGDESTIEDFSAYFGALLQYPTCDGEIVDYRELVSRFHAVDALVAVAADLLALTLLTPPGEFGADVAIGSAQRFGVPLGFGGPHAAYFATRDAFKRDMPGRLVGVSIDRHGKPAYRLAMQTREQHIRREKATSNICTAQVLLANIASMFAVYHGPQGLLRIARRTHRLTAILAAGLERLGVAVEQKHFFDTLSLATGARTAAIHAKARAAGINLREIDAGRLGLSLDETVRQTDVETLWGLLAEEGQALPDFAALAASSGDRLPVELLRQSAILSHPIFNRHHSETELMRYLRKLADKDLALDRTMIPLGSCTMKLNAASEMIPVTWAEFGNLHPFAPAEQSEGYRQLTDELEAMLCSATGYDAVSLQPNAGSQGEYAGLLAIRAYHQSRGDSQRDICLIPSSAHGTNPATASMVGMRVVVVACDARGNVDVEDLRNKASEHKERLAALMITYPSTHGVFEEAIREICAIVHDCGGQVYIDGANMNAMVGLCAPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPIGVRAHLAPFLPGHARGERKEGAVSAAPYGSASILPITWMYIRMMGGEGLKRASEMAILNANYIAHRLEEHYPVLYAGGNGLVAHECILDLRPLKDSSGISVDDVAKRLMDFGFHAPTMSFPVAGTLMIEPTESESKAELDRFCDAMIRIREEIRAVERGELDKEDNPLKNAPHTAAELLGEWNHAYSREQAAYPLASLVEAKYWPPVGRVDNVYGDRNLTCSCPPIEAYSEE
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 103919 Sequence Length: 959 EC: 1.4.4.2
Q88P65
MTINLGTANEFIARHIGPRAADEQAMLTALGFDSLDAMTAAVIPDSIKGTSVLGSHDGQSEADALAALKAIAGKNQLFKSYIGQGYYNTHTPAPILRNLLENPAWYTAYTPYQPEISQGRLEALLNFQTLISDLTGLPIANASLLDEATAAAEAMTFCKRLSKNKSSHAFFASVHCHPQTLDVLRTRAEPLGIEVVVGDERELGDVSAFFGALLQYPASNGEVFDYREVVQRFHAANALVAVAADLLALTLLTPPGEFDADVAIGSAQRFGVPLGFGGPHAAYFATRDAFKRDMPGRLVGVSIDRFGKTALRLAMQTREQHIRREKATSNICTAQVLLANIASMFAVYHGPAGLKRIAERTHALTAILAAGLKALGVQVVGASAFDTLTLATGTATASLHDKARAQGINLRQIDAAHVGLSLDETSTQADVESLWQLLGGEQAQPDFTALAASTGSLLPAALLRQSAILEHPVFNRYHSETELMRYLRRLADKDLALDRSMIPLGSCTMKLNAASEMIPVTWAEFGNLHPFAPAEQSQGYLQMTTELEAMLCAATGYDAVSLQPNAGSQGEYAGLLAIRAYHRSRGEGHRDICLIPSSAHGTNPATAHMAGMRVVVTACDARGNVDVEDLRAKAIEHRERLAAIMITYPSTHGVFEEAIGEICAIIHDNGGQVYIDGANMNAMVGLCAPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPIGVKSHLAPFLPGHAQLENTQGAVCAAPFGSASILPITWMYIRMMGGAGLKRASQMAILNANYIARRLEEHYPVLYTGGNGLVAHECILDLRPLKDTSGISVDDVAKRLIDFGFHAPTMSFPVAGTLMIEPTESESKEELDRFCNAMIQIREEIRAVEDGSLDKDDNPLKNAPHTAAELVGEWTHGYSREQAVYPLASLVEGKYWPPVGRVDNVFGDRNLVCACPSIESYQDA
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 101992 Sequence Length: 951 EC: 1.4.4.2
C1F935
MRYLPKSPADREAMLREIGAASIDELFAIIPEEFRLTRDLAIPRQMGESEIVDHFQAAAARNANGYASFLGAGAYRHYRPVLIDTIVQRGEFLTSYTPYQAEITQGTLQAIFEFQTMICELTGMDIANASMYDGSTGAAEAVMMAIRVTGRDKVLVSRSVHPEYREVMHTYAQHQGHDAAEVEYIREGAQAGRVDLAALEAAVTEETACVLVQSPNFFGVIEDIPAIAEIAHKKGALLIVSIAEALSLGAVRPPVEADIVSLEAQSFGVALSYGGPYCGVLAAKEKYLRQMPGRLVGETKDSQGRRGFVLTLSTREQHIRREKATSNICTNQALVALMATVYMTIYGKQGIKDLALQNLAKADYAAKTLGQSGKLLFAGSPRFHEFVLETSETPAQVNERLLEEKIIGGLPLGKWYPELGHAALWCATEVTTREQIDRAAQVLAHAPALAAR
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 49316 Sequence Length: 452 EC: 1.4.4.2
Q9YA15
MEHPWIPNSHKAILDEMLEAIGVSSVDDLYRDIPPTILLSPEEWDSLPIGEGRPLSEAEVLARINDILSRNKYFTDPPPFVGGGVWPRYVPSVVKALITRGEFLTAYTPYQAEISQGLMQALFEYQSLVAELLEMEVVNASLYDWSSAVGEAMLMARRVTRRNRVLVPETMNPLHLETATTYAYGGGIRVEKVRVDRETGFIDLEDLESRLSQGDTAALYMEYPSSYTGVIDENVEAAGEAVHKAGGLFILGVEPVSMAILKPPGRLGADIAVGDGQPLGLGLNYGGPYLGVFAVRWDGRLVRQMPGRLIGMTVDAEGRRAFAMILQTREQHIRRAKATSNITTNEALMAIAAAVYLSLLGPQGLREVAEASWYMSHYAAKRLSELRGVEAPLLEGEFIMDFTVRLPMDAGVARRRLLEKGVLAGIPLGGFSFFSDNDMLLTVTEAHTRRHVDLLVNLLDSVLGG
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 51103 Sequence Length: 465 EC: 1.4.4.2
Q2IQD6
MRYHPHTPDDVRAMLDVVGAERVDDLFRSIPQALRLDRPLDLPPAADEIALFSELRRLAARNETAHPPFVGAGCYPHHVPPVVDQLLLRGEFFTAYTPYQPEISQGTLQALFEWQTFVCLLTGMDVSNASMYDGATATAEAALMAGRITGRDKVVVSAALHPEYRKVLATYLRSTGDEIVTVPFGADGRTDLAALQQAVDGRTACVILGYPNFLGVVDALPEAAAIARKAGALTVSATAEAVSLGLLQAPGALGADVAVGTFQSFGNPMSFGGPAPGFFATREKHVRQMPGRVAGATVDKQGRRGFVLTLSTREQHIRREKATSNICTNSGLCALASTVHLSLLGKRGLAELARLNHGRARMLRDAMERAGCRPVFSGPFFNEQVFDVGDAEAVVAKLAKRGIVAGAPLARWFPDAPSAKGALLCAATELHGPELIQLFAGAVRS
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 47431 Sequence Length: 445 EC: 1.4.4.2
O67193
MSYIPHSEEETKEILSKLGLESLEDLFSHIPKELFAKDFSFPEPKSEEELRRIFERACEDTELPLYFIGAGAYDRIIPSVIWQILSRGEFLTPYTPYQAEASQGTLQAIFEYQSLICELTGMDVANASMYDGASALAEAVLMARAIKGKGDTVVLSKALNPLYRRTVKTYLRGYEDKIVEVPYTEEGTTDLNNLEEVLKESEVHALAVQYPNFFGFVEPLKEIGELCKKYEVPFVVFVDPIALSILKPPAEFGADIVVGEGQQMGIPLSFGGPYVGFFATKKEHVRKMPGRLVGMGEDIEGKRAFTLVLQTREQHIRRERATSNICTNQNLMALANLLYMVLLGKEGMKKVAVQSLSKALYFKKELMKKGFEEVFTGKHLWEFPLRHESLKAIYRKLLKEKIVLGLPLDRFYEDLKNTTLIAVTEKRTKEEIDSVLALL
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 49722 Sequence Length: 439 EC: 1.4.4.2
P54377
MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDEDAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIHPLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGDFKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTNPNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFTGPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGINVRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKKLGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKEAEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity). Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 54427 Sequence Length: 488 EC: 1.4.4.2
Q9A354
MNNVGRPTRPEAANDAANGHETLTGARGLLQDEALIFELDGWNKTGVDLPPVTAAPSSDLNGLLRDAPIGLPGLSEPETVRHYVRLSQKNHAIDLALYPLGSCTMKHNPRLNEKMARLPGFSDIHPLQPQSTVQGALELMDRLAHWLKTLTGMPAVALTPKAGAHGELCGLLAIRAAHEAAGNGHRKTVLAPTSAHGTNPATAAFVGYTVVEIAQTEDGRVDLADLESKLGDHVAAIMVTNPNTCGLFERDVVEIARLTHAAGAYFYCDGANFNAIVGRVRPGDLGVDAMHINLHKTFSTPHGGGGPGAGPVVLSEALAPFAPTPWLTHGDNGFELAEHAGDDDAKTAFGRMSAFHGQMGMYVRAYAYMLSHGADGLRQVAEDAVLNANYIKAQLKDVMSPAFPEGPCMHEALFDDSWLEGTGVTTLDFAKAMIDEGFHPMTMYFPLVVHGAMLIEPTETESKHELDRFIAALRALAGAAKAGDTERFKGAPFHAPLRRLDETQAARKPRLRWKPVAAAPLAAE
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 55993 Sequence Length: 524 EC: 1.4.4.2
Q8KAN3
MKEQLIFDLSRSGRKGYSLSPLDIPERPADELLPSKFLRKEPAELPEMAESEVVRHFIRLSNLNYHVDKNMYPLGSCTMKYNPKINDYTCDLPGFASMHPLQPESTSQGALQLMYELAEMLKEIAGMKAVTLQPAAGAHGELTGILLIKKYHEKLGNKRHKLLVVDSAHGTNPASAALGGYECVSVKCDESGCTDMGDLRAKLDGEVAALMLTNPNTVGIFEKQIPEIEKLVHGNGSLLYMDGANMNALLGITRPGDMGFDVMHYNLHKTFSAPHGGGGPGSGPVGVSERLVEFLPVPVIEKFEKDGQTRYRLNSSKPNTIGRMMNFYGNFSVLVRAYTYIRMLGADGLRRVSENAIINANYLLQRLVEHYALPYPRPVMHEFCLSGDRQKKEHGVRTLDIAKRLLDYGYHAPTVYFPLIVSEALMIEPTETEAKETLNAFADAMIAIAEEAKSNPDLIKSAPTTTPVKRLDEAQASRQLNICCQH
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 53810 Sequence Length: 486 EC: 1.4.4.2
A4J2F9
MTEKLIFELGSPGRQGVLFPANDVPEIPPHELLPRDLIREQEVPLPEVSEGDAVRHFVRLSRMNFGVDVGFYPLGSCTMKYNPKVAEDAAGLSGFANIHPYQPDEISQGALQLMYETQQDLAEITGMDAFTLQPAAGAQGELTGMLIIKAYLESKGETGRNKVIVPDSAHGTNPATAALCGFKVVEVKSDQRGGVDLAALKQLLGPDVAALMLTNPSTLGLFEDNITEIAALVHQAGGLLYYDGANLNAIMGYARPGDMGFDVVHLNLHKTFGTPHGGGGPGSGPVGVKAELAPFLPKPVIIQREGNYLPDYHRPQSIGRVKAFFANFSVIVKAYTYLRSLGGKGLKEVSEHAVLNANYLMKQLSDHFRVPYQRTCMHEFVVSPPEDMKEQGIKTLDIAKRLLDYGYHPPTVYFPLIVEEALMFEPTETESKETLDEFAHNLIKVLAEARENPDKLRNAPYTTPIRRLDEVMAARKPLVGWFPE
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 53106 Sequence Length: 484 EC: 1.4.4.2
A7HLP1
MTIFEKSTSGRKGYELPEYELPSVDCGIPEHLVRKEKPLLPEVSEVDVVRHYTELASKNYSVDKGFYPLGSCTMKYNPKINEDMAMLFTQLHPMQPRETIQGAIDLMGHLKEMLCEITGTDDMTLQPAAGAHGELTGLLVARAYFEDKGELDKRRKVLVPDSAHGTNPASAAMAGFEVVELKSGKDGCVNLEELKAHLDENVAVIMLTNPNTLGLFEKDILTIAKMAHEVGALLYYDGANLNAIMGRTRPGDMGFDIVHLNLHKTFSTPHGMGGPGSGPIGVKKHLAPYLPVPVIRKAGEKYDLDYNLPKSIGMVRSFYGNFTVMVKAYTYILTMGNKGLKHVSDMAVLNANYLRAKLSKIYKVAYDRICMHEFVIDNEEFVKKTGVKTLDIAKRLLDYGLHAPTVYFPLIVHEAMMIEPTETESKRTLDEFIDAMEKIYNEAIENPELVKKAPYKTPIRRLDDVNATKYPVFRYKK
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 53430 Sequence Length: 477 EC: 1.4.4.2
Q7VET8
MSDHSTFADRHIGLDSQAVATMLAVIGVDSLDDLAVKAVPAGILDTLTDTGAAPGLDSLPPAASEAEALAELRALADANTVAVSMIGQGYYDTHTPPVLLRNIIENPAWYTAYTPYQPEISQGRLEALLNFQTLVTDLTGLEIANASMLDEGTAAAEAMTLMHRAARGPVKRVVVDADVFTQTAAVLATRAKPLGIEIVTADLRAGLPDGEFFGAIAQLPGASGRITDWSALVQQAHDRGALVAVGADLLALTLIAPPGEIGADVAFGTTQRFGVPMGFGGPHAGYLAVHAKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNICTAQVLLAVLAAMYASYHGAGGLTAIARRVHAHAEAIAGALGDALVHDKYFDTVLARVPGRADEVLARAKANGINLWRVDADHVSVACDEATTDTHVAVVLDAFGVAAAAPAHADIATRTSEFLTHPAFTQYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMESITWPEFGRQHPFAPASDTAGLRQLVADLQSWLVLITGYDAVSLQPNAGSQGEYAGLLAIHEYHASRGEPHRDICLIPSSAHGTNAASAALAGMRVVVVDCHDNGDVDLDDLRAKVGEHAERLSALMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPFLPGHPFAPELPKGYPVSSAPYGSASILPITWAYIRMMGAEGLRAASLTAITSANYIARRLDEYYPVLYTGENGMVAHECILDLRGITKLTGITVDDVAKRLADYGFHAPTMSFPVAGTLMVEPTESESLAEVDAFCEAMIGIRAEIDKVGAGEWPVDDNPLRGAPHTAQCLLASDWDHPYTREQAAYPLGTAFRPKVWPAVRRIDGAYGDRNLVCSCPPVEAFA
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 99453 Sequence Length: 941 EC: 1.4.4.2
B8ZSN5
MSVPNSSNKQTCFTARHIGPNSEDVATMLAVIGVESLDDLAAKAVPSDILDNVTDTGVAPGLDRLPPPATESETLAELGALARANTVAVSMIGQGYYDTLTPAVLSRNILENPAWYTPYTPYQPEISQGRLEALLNFQTLVSDLTGLEIANASMLDEGTAAAEAMTLMYRAARSTASRVVVDVDVFAQTVAVFATRAKPLGIDIVVADLREGLPDGEFFGVITQLPGASGRITDWTALIAQAHSRGALVAVGADLLALTLITPPGEIGADVAFGTTQRFGVPMGFGGPHAGYLALHTKHARQLPGRLVGVSVDSDGTPAYRLALQTREQHIRRDKATSNICTAQVLLAVMAAMYASYHGAEGLTGIARRVHAQARALAAGLSAAGVEVVHQAFFDTVLARVPGRTVQIQGAAKERGINVWLVDGDHVSVACDEATTDEHITAVLAAFAATPARASFAGPDIATRTSAFLTHPTFTKYRTETSMMRYLRALADKDIALDRSMIPLGSCTMKLNAAAEMESITWQEFTRQHPFAPVSDTPGLRRLISDLESWLVQITGYDAVSLQPNAGSQGEYAGLLAIHDYHVSRGEPHRNVCLIPSSAHGTNAASAALVGMRVVVVGCHDNGDVDLDDLRIKLSEHANRLSVLMITYPSTHGVYEHDIAEICAAVHDAGGQVYVDGANLNALVGLARPGKFGGDVSHLNLHKTFCIPHGGGGPGVGPVAVRSHLVSFLPGHPFAPELPQGQPVSSAPYGSASLLPITWAYIRMMGADGLRTASLTAIASANYIARRLDKYFPVLYTGENGMVAHECILDLRPITKSVGVTVDDVAKRLADYGFHAPTMSFPVPGTLMVEPTESESLAEIDAFCEAMIAIRGEIARVGAGEWSVEDNPLRGAPHTAECLLASDWDHPYTREEAAYPLGKAFRPKVWPPVRRIDGVYGDRNLVCSCLPVEAFV
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. Catalytic Activity: (R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2 Sequence Mass (Da): 101283 Sequence Length: 952 EC: 1.4.4.2
Q3AET7
MENLKRTPLYEEHIKLGAKMVPFGGWEMPVQYTGILEEHMAVRTDVGMFDVSHMGEIEITGKQAERFVNYLITNDVSRLNSGDVIYTTMCYPDGGTVDDLLAYKYSTERYLLVVNAANKDKDLAHILQYRWDDVTVTDLSDETAEIALQGPRAQEILQKLTAFDLNQIKYFGFAEIEVAGVPCLVSRTGYTGEDGFEIYFAPNLATKIWNELLNLGVKPAGLGARDTLRFEACLPLYGHELSAEITPLEAGLGWAVKFNKEDFIGKEALLAQKNAGLKRKIVGLEMIGAGIPRQGYEIVFNQRGVGFVTSGTFAPFLKKNLAMAMVDLEAAEIGTEVDVIIRGKGVRARVISRPFYKRGK
Function: The glycine cleavage system catalyzes the degradation of glycine. Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) Sequence Mass (Da): 40036 Sequence Length: 360 EC: 2.1.2.10
P28337
MLRAGCRAALARRHLSSAPEGLKQTPLDALHRARGGRMVPFAGWSLPVQYGRGHLESHLHTRRHCSLFDVSHMLQTRVYGRDRVRFLESLVVGDIAELRPGQGTLTLLTNERGDIVDDLIVTNTAEDHLYVVSNAGCADKDRAVMEGRAAELRAAGGDVHLEVSGQRAAGVQGPSMAQVLQAGLPDDLTKLTFMTSTATTVFGVPGCRVTRCGYTGEDGVEISVPAGRAVELAERLLGCPEVWPAGLAARDSLRLEAGLCLYGNDIDESTTPVEAGLLWTLGKRRRTAMDFPGAAIIMEQVKEKPKRKRVGLTSVGPPLRPPAAILGPEGTPVGTVTSGCPSPSLGKNIAMGYVQAAHSRPGTTLTVEVRKKQHPALVTKMPFVPTHYYMAK
Function: The glycine cleavage system catalyzes the degradation of glycine. Catalytic Activity: (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) Sequence Mass (Da): 42058 Sequence Length: 392 Subcellular Location: Mitochondrion EC: 2.1.2.10
B2KSJ5
MSSQVSNFPASIMKTNDIPDVKRSLANFHPNIWKEHFLSFTFDDALKIDEGMKERTEKLKEEIRMMMIAYVENQLIKLNLVDSIQRLGVSYHFEDEVDEFLEHIYVSYNNSLLLSNKNSNGEDLHITALLFRLLRQQGYRISCDIFLKFMDDNGKFKESLVEDERGLLSLYEASHMMGHGEALLEEALEFTTTHLQTYIHRYSNINPSFASEVSNALKLPIRKSVPRIKAREYLEIYQQHPSHNETLLEFSKLDFNILQKLHQKELSEICRWWKDLDVPTKFPFARDRIVECYFWTLGAYFEPQYSVGRKMLTKVIAIASILDDIYDAYGTFEELQVLTPAIQRWDRSMVHTLPLYMKPFYVAMLELYEEIGKEIDKDQNSLHLQVAIGGIKRLSESYFEEAKWLNKEYKPSFKEYMELALKTTGYTMLISISFLGLGDHIVTNEVLQWLSNGPQIIKASTIICRLMDDIASHKFEQEREHVASAVECYMKQYDCSEEEACIELHKEVVDAWKDTNEAFYRPFNVPVPVLMRVLNFSRVINLLYLDEDGYTNAKSGTKFLIKSLLVDPLPC
Cofactor: Binds 3 Mg(2+) ions per subunit. Function: Sesquiterpene synthase producing mainly delta- and gamma-cadinene with traces of several other sesquiterpenoids, including alpha-copaene. Associated with the production of sesquiterpenes responsible for the aroma of the fruit. Catalytic Activity: (2E,6E)-farnesyl diphosphate = (+)-gamma-cadinene + diphosphate Sequence Mass (Da): 66633 Sequence Length: 571 Domain: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Pathway: Secondary metabolite biosynthesis; terpenoid biosynthesis. Subcellular Location: Cytoplasm EC: 4.2.3.13
Q8GY54
MVLWVFGYGSLIWNPGFDFDEKLIGYIKDYKRVFDLACIDHRGTPEHPARTCTLEQSTGAICWGAAYCVRGGPEKEKLAMEYLERRECEYDSKTLVEFYTENDTSTPIVTGVIVFTSTPDKVSNKYYLGPAPLEEMARQIATASGPCGNNREYLFKLEKAMFDIEHEEEYVIELANEVRKQLDLPEEVKALLKPIVSHVSVKSQAHVSTRQRVFAS
Cofactor: Binds 2 Mn(2+) ions per subunit. Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and plays a significant role in glutathione (GSH) homeostasis. Converts both GSH and gamma-glutamyl-L-alanine to 5-oxoproline in vitro. Plays a role in detoxification of heavy metals and metalloids by recycling glutamate and maintaining GSH homeostasis. Catalytic Activity: an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid Sequence Mass (Da): 24573 Sequence Length: 216 Subcellular Location: Cytoplasm EC: 4.3.2.9
Q84MC1
MVMWVFGYGSLVWNPGFHYDEKVLGFIKGYKRVFDLACIDHRGTPEHPARTCTLEKAEEAICWGTAFCVRGGPEKERLAMEYLERRECEYDLKTSVDFYKEDDPLKPAVTGVIVFTSTPDKVSNKYYLGPAPLEDMARQIATANGPCGNNRDYLFLLEKAMHDIGHEEDYVIELANEVRKVLAESSTKKVTPVKESRASRVANKSKNNVPTAHQILPHHPEAVATTI
Cofactor: Binds 2 Mn(2+) ions per subunit. Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and plays a significant role in glutathione (GSH) homeostasis. Converts GSH to 5-oxoproline and cysteine-glycine (Cys-Gly) dipeptide in vitro. Possesses low activity towards gamma-glutamyl-L-alanine. Has no activity towards gamma-glutamyl-L-cysteine. Catalytic Activity: an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid Sequence Mass (Da): 25607 Sequence Length: 227 Subcellular Location: Cytoplasm EC: 4.3.2.9
Q84QC1
MAMWVFGYGSLIWKTGFPFDESLPGFIKGYRRVFHQGSTDHRGTPDFPGRTVTLEAAHEEVCCGVAYKITKEEDKRDALLHLEVREKQYDQKEYLDFFTDSNASEPAVAGVMVYIASPDKKSNNNYLGPAPLEDIAKQIVKAKGPSGPNRDYLFNLEEALAQLGFKDKHVTDLANQVRHILSESEELDIDATAATANNV
Cofactor: Binds 2 Mn(2+) ions per subunit. Function: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and plays a significant role in glutathione (GSH) homeostasis. Converts GSH to 5-oxoproline and cysteine-glycine (Cys-Gly) dipeptide in vitro. Possesses low activity towards gamma-glutamyl-L-alanine. Has no activity towards gamma-glutamyl-L-cysteine. Catalytic Activity: an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid Sequence Mass (Da): 22229 Sequence Length: 199 Subcellular Location: Cytoplasm EC: 4.3.2.9
Q59111
MSKVMTLKDAIAKYVHSGDHIALGGFTTDRKPYAAVFEILRQGITDLTGLGGAAGGDWDMLIGNGRVKAYINCYTANSGVTNVSRRFRKWFEAGKLTMEDYSQDVIYMMWHAAALGLPFLPVTLMQGSGLTDEWGISKEVRKTLDKVPDDKFKYIDNPFKPGEKVVAVPVPQVDVAIIHAQQASPDGTVRIWGGKFQDVDIAEAAKYTIVTCEEIISDEEIRRDPTKNDIPGMCVDAVVLAPYGAHPSQCYGLYDYDNPFLKVYDKVSKTQEDFDAFCKEWVFDLKDHDEYLNKLGATRLINLKVVPGLGYHIDMTKEDK
Function: Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. Catalytic Activity: acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate Sequence Mass (Da): 35722 Sequence Length: 320 Pathway: Amino-acid degradation; L-glutamate degradation via hydroxyglutarate pathway; crotonoyl-CoA from L-glutamate: step 3/5. Subcellular Location: Cytoplasm EC: 2.8.3.12
Q59112
MADYTNYTNKEMQAVTIAKQIKNGQVVTVGTGLPLIGASVAKRVYAPDCHIIVESGLMDCSPVEVPRSVGDLRFMAHCGCIWPNVRFVGFEINEYLHKANRLIAFIGGAQIDPYGNVNSTSIGDYHHPKTRFTGSGGANGIATYSNTIIMMQHEKRRFMNKIDYVTSPGWIDGPGGRERLGLPGDVGPQLVVTDKGILKFDEKTKRMYLAAYYPTSSPEDVLENTGFDLDVSKAVELEAPDPAVIKLIREEIDPGQAFIQVPTEAK
Function: Catalyzes the transfer of the CoA moiety from acetyl-CoA to (R)-2-hydroxyglutarate and related compounds like glutaconate. Catalytic Activity: acetyl-CoA + trans-glutaconate = (2E)-glutaconyl-CoA + acetate Sequence Mass (Da): 29166 Sequence Length: 266 Pathway: Amino-acid degradation; L-glutamate degradation via hydroxyglutarate pathway; crotonoyl-CoA from L-glutamate: step 3/5. Subcellular Location: Cytoplasm EC: 2.8.3.12
O18836
MQKLQISVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACLWRENTTSSRLEAIKIQILSKLRLETAPNISKDAIRQLLPKAPPLLELIDQFDVQRDASSDGSLEDDDYHARTETVITMPTESDLLTQVEGKPKCCFFKFSSKIQYNKLVKAQLWIYLRPVKTPATVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPEPGEDGLTPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGEGQIIYGKIPAMVVDRCGCS
Function: Acts specifically as a negative regulator of skeletal muscle growth. PTM: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. Sequence Mass (Da): 42551 Sequence Length: 375 Subcellular Location: Secreted