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S1083879119305592 | Mycosis fungoides and Szary syndrome are the most common types of primary cutaneous T cell lymphomas . The clinical presentation of mycosis fungoides is generally indolent whereas Szary syndrome represents a more aggressive disease variant . Stage at diagnosis is the most important determinant of long term survival out... | This systematic review and meta analysis demonstrates the efficacy of allo HCT in CTCL. Pooled OS rates of 59 were observed in spite of advanced disease in most cases. A pooled PFS rate of 36 highlights the risk of the disease relapse after allo HCT. |
S1083879119305609 | We analyzed the outcomes of 26 consecutive patients with acquired severe aplastic anemia undergoing peripheral blood stem cell transplantation with partial ex vivo T cell depletion with a targeted T cell dose from HLA identical sibling donors . The median patient age was 37 years . Four patients with uncontrolled pneum... | PBSCT from HLA identical siblings using partial T cell depletion for patients with SAA is safe and associated with a low incidence of acute GVHD and chronic GVHD. The procedure is effective with high engraftment low TRM and high cure rates. |
S1083879119305610 | Little is known about stem cell transplantation in solid organ transplantation recipients . We conducted a nationwide retrospective survey of Japan Society for Hematopoietic Stem Cell Transplantation centers . A total of 19 patients who underwent 22 hematopoietic stem cell transplantations after SOT were identified 5 a... | A nationwide survey in Japan identified 22 hematopoietic stem cell transplantation HSCT procedures in 19 solid organ transplantation SOT recipients. Successful hematologic engraftment aids HSCT for aplastic anemia after SOT. Disease control before HSCT is crucial in SOT recipients with malignant disease. Renal failure ... |
S1083879119305622 | Allogeneic hematopoietic cell transplantation has been increasingly offered to older adults with hematologic malignancies . However optimal methods to determine fitness for alloHCT have yet to be defined . We evaluated the ability of a comprehensive geriatric assessment to predict post alloHCT outcomes in a single cent... | Functional status predicts post allogeneic transplantation survival in older patients. Physical function predicts both post allogeneic transplantation survival and toxicity. These associations were independent of age and comorbidities. |
S1083879119305646 | The rationale for in utero hematopoietic cell transplantation rests on exploitation of normal events during hematopoietic and immunologic ontogeny to allow allogeneic hematopoietic engraftment without myeloablative conditioning . Host hematopoietic competition is among the primary barriers to engraftment in IUHCT . In ... | Highly enriched donor cell populations engraft poorly in a murine model of IUHCT. The addition of accessory BM MNC to an enriched population improves engraftment. This is a practical and clinically applicable strategy to increase donor chimerism. |
S1083879119305658 | Transplantation associated thrombotic microangiopathy is an important complication of hematopoietic stem cell transplantation . To date information regarding the organs that are affected by TA TMA as confirmed histologically remains limited the clinicopathologic differences between renal TA TMA and intestinal TA TMA ha... | We systemically evaluated transplantation associated thrombotic microangiopathy TA TMA in the largest number of autopsied patients. The kidney and intestine were commonly affected by TA TMA. Many organs were initially histologically confirmed as TA TMA sites. The histologic overlap of renal and intestinal TA TMA was ra... |
S108387911930566X | Umbilical cord blood provides an alternative source of hematopoietic stem cells for allogeneic transplantation . Administration of sufficient donor HSCs is critical to restore recipient hematopoiesis and to maintain long term polyclonal blood formation . However due to lack of unique markers the frequency of HSCs among... | Cellular barcodes allow for quantitative longitudinal tracing of human hematopoietic stem cells HSCs in murine recipients. The frequency of HSCs is highly variable between individual cord blood donors. Different analysis methods can cause substantial variation in the number of retrieved clones. |
S1083879119305671 | Bone marrow is a rich source of hematopoietic stem cells mesenchymal stem cells and other important stem progenitor cells . It is the traditional source of cells used in hematopoietic cell transplantation which is a proven curative treatment for many blood and immune diseases . BM derived cells have also been shown to ... | MarrowMiner is a safe minimally invasive device for the harvest of bone marrow. MarrowMiner harvests bone marrow without the need for general anesthesia. MarrowMiner collects rich marrow with a high concentration of stem and progenitor cells. |
S1083879119305683 | The use of hematopoietic stem cell transplantation is increasing for a variety of diseases . Ototoxicity from this procedure has not been extensively studied . A retrospective chart review examined 275 patients from this institution who underwent HSCT between January 1 2007 and April 30 2017 . Data extracted included t... | This is the largest series of pediatric HSCT recipients evaluated for ototoxicity reported to date. Ototoxicity was observed in 10 of the patients examined. No type of transplantation was free of ototoxicity. Patients with evidence of hearing loss before the transplantation procedure were at greatest risk. |
S1083879119305695 | Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment for patients with myelodysplastic syndromes and myelodysplastic myeloproliferative neoplasms . However post HSCT relapse remains a major cause of treatment failure . Here we assessed the efficacy of a new conditioning regimen compris... | Until now decitabine has been used more often for bridge treatment before allogeneic hematopoietic stem cell transplantation allo HSCT or rescue treatment of relapsed myelodysplastic syndrome MDS after transplantation. In this study 5 day decitabine was added for the first time to the conditioning regimen with a satisf... |
S1083879119305701 | Previously reported experimental and clinical data suggest that proteasome inhibition may have immunomodulatory activity relevant to graft versus host disease . To explore the safety and activity of carfilzomib in advanced chronic GVHD we conducted a multicenter pilot phase II trial through the Chronic GVHD Consortium ... | Once weekly carfilzomib therapy was not well tolerated in patients with advanced chronic GVHD. With limited evidence of efficacy we do not recommend this agent for further study in this indication. |
S1083879119305737 | Uncontrolled studies have suggested that bone marrow derived mesenchymal stem cells may be effective against acute graft versus host disease . We conducted a multicenter randomized study to assess the efficacy of using ex vivo cultured adult human MSC in addition to second line therapy to treat steroid refractory aGVHD... | Mesenchymal stem cells MSC versus placebo added to second line therapy for treatment of steroid refractory acute graft versus host disease aGVHD did not show benefit. MSC infusions were well tolerated and did not result in excess adverse events compared with placebo. Post hoc subgroup analyses suggested favorable odds ... |
S1083879119305750 | Post autologous stem cell transplantation maintenance therapy with lenalidomide is standard of care for patients with multiple myeloma . Effective and tolerable drug combinations may further enhance the clinical response post ASCT . Vorinostat a histone deacetylase inhibitor induces antiproliferative and proapoptotic e... | The combination of vorinostat and lenalidomide as maintenance post transplantation is tolerable and induces durable response. With a median follow up of 89.8 months from autologous stem cell transplantation the median progression free survival was 64.3 months range 21.7 months to not reached NR and overall survival was... |
S1083879119305762 | Molecular data and minimal residual disease have been shown to influence outcomes in acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplantation . Here we developed and validated a novel AML specific disease risk group and revised our previously developed hematopoietic cell transplant compo... | Molecular data and MRD at transplant for AML patients significantly influence outcomes. By incorporating these factors we developed an AML DRG which has improved predictive ability compared with the DRI. A risk model combining patient and disease related factors the HCT CR effectively predicts OS for AML. The AML HCT C... |
S1083879119305932 | High dose chemotherapy followed by autologous hematopoietic stem cell transplantation improves survival in patients with chemosensitive non Hodgkin lymphoma . Determination of the Hematopoietic Cell Transplantation Comorbidity Index has contributed to improve patient selection while allowing for prediction of nonrelaps... | Quality of life is well preserved after autologous hematopoietic stem cell transplantation AHSCT in older patients. Relapse remains one of the main challenges affecting quality of life. Self care is the least affected area after undergoing AHSCT. Older patients should not be excluded from AHSCT based solely on their ag... |
S1083879119305944 | The high cost of healthcare in the United States has not been consistently associated with improved health outcomes or quality of care necessitating a focus on value based care . We identified busulfan dosing frequency during allogeneic hematopoietic cell transplantation conditioning as a potential target for optimizat... | Every 24 hour q24h dosing of i.v. busulfan reduced drug waste compared with every 6 hour q6h dosing. Reduced busulfan drug waste led to a cost savings of nearly 20 000 USD per patient. Clinical outcomes were equivocal or improved with q24h dosing compared with q6h dosing. |
S1083879119305956 | Induced pluripotent stem cells have been applied to clinical regenerative cell therapy . Recently an iPSC banking system to collect HLA haplotype homozygous cells for iPSC transplantation in allogeneic settings was proposed and tissue transplantation generated from iPSC through banking has just began . We analyzed 5017... | All assessable patients with donor HLA homo to patient HLA hetero pairs among 5017 single CBT pairs were engrafted neutrophil 38 pairs and platelets 30 pairs and revealed a tendency of high incidence of acute GVHD. Ethnicity specific conserved extended HLA haplotypes CEHs were invariably shared with the same donor HP i... |
S1083879119305968 | Little is known about the inflammatory milieu in the blood during autologous hematopoietic stem cell transplantation and how it is affected by the stem cell mobilization collection and reinfusion and conditioning regimen . In this study we analyzed 92 proteins connected to inflammation at 10 time points during and afte... | Inflammatory serum proteins are profoundly altered by conditioning regimen for autologous hematopoietic stem cell transplantation AHSCT . Two distinct patterns of serum proteins are distinguished during AHSCT. There are no visible effects of MS disease activity on inflammatory serum proteins. Serum protein levels are n... |
S1083879119306263 | The third annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling was held on November 29 2018 at the American Society of Hematology annual meeting . This workshop featured the latest research focused on minimal residual disease assessment ... | This is a comprehensive summary from the third annual Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Minimal Residual Disease MRD and Immune Profiling IP workshop. MRD is not yet established as a surrogate endpoint but is a prognostic biomarker. Incorporation of IP as an exploratory endpoint in ... |
S1083879119306275 | To prospectively validate the incidence manifestations and outcomes of graft versus host disease by National Institutes of Health criteria we recruited 406 hematopoietic stem cell transplantation recipients at 16 transplant centers in Japan from May 2012 to June 2014 . The 2 year cumulative incidence of late acute and ... | The incidences of late acute and chronic graft versus host disease GVHD were lower in Japanese than in whites. Organ manifestations and risk factors were similar to previous reports. Global severity was not associated with overall survival nonrelapse mortality or GVHD specific survival. Severe patients showed a signifi... |
S1083879119306287 | Cyclophosphamide etoposide combined with fractionated total body irradiation or i.v . busulfan has been the main conditioning regimens for allogeneic hematopoietic cell transplantation for young patients with acute myelogenous leukemia eligible for a myeloablative conditioning regimen . Recent data has suggested that i... | Fractionated total body irradiation based myeloablative conditioning is well tolerated in young adults with acute myelogenous leukemia. Tacrolimus sirolimus graft versus host disease GVHD prophylaxis was associated with high rates of chronic GVHD 71 . GVHD free relapse free survival at 2 years was low 39 indicating the... |
S1083879119306329 | Almost comparable transplantation outcomes have been reported with HLA matched unrelated donor transplantation and cord blood transplantation . We conducted a prospective phase 2 study to assess the efficacy and safety of single unit myeloablative CBT in adult leukemia and myelodysplastic syndrome . Because the day 180... | We conducted a phase 2 single arm prospective study of cord blood transplantation CBT . We assessed the efficacy of CBT for treating patients with adult acute leukemia and myelodysplastic syndrome. CBT showed significantly better day 180 overall survival than threshold survival. CBT outcomes are comparable to historica... |
S1083879119306342 | FLT3 ITD mutated acute myeloid leukemia remains a therapeutic challenge . FLT3 inhibition in the setting of minimal residual disease and a new immune system via allogeneic transplantation offers a promise of improved survival for these patients . We performed a prospective study of patients with FLT3 ITD AML undergoing... | Sorafenib is safe and well tolerated before and after transplant if dosed according to patient adverse effects. Sorafenib use after transplant is associated with encouraging post transplant survival in patients with FLT3 ITD acute myeloid leukemia undergoing hematopoietic stem cell transplant. Sorafenib dosing accordin... |
S1083879119306354 | The Predicted Indirectly Recognizable HLA Epitopes score quantifies the number of PIRCHEs in patient donor pairs and represents an in silico measure of indirect alloreactivity . This biologic process is defined as T cell recognition of epitopes derived from mismatched allogeneic HLA peptides that are subsequently prese... | PIRCHE scores offer a method of quantifying indirect T cell alloreactivity. PIRCHE scores offer a broad range of measurement of HLA disparity. Graft versus host PIRCHE scores correlate with acute graft versus host disease. PIRCHE scores may improve donor selection in haploidentical transplantation. |
S1083879119306366 | The optimal intensity of conditioning regimen may be dependent on not only age and comorbidities but also disease characteristics and risk of relapse after allogeneic hematopoietic cell transplantation . We therefore analyzed the transplant outcomes of 840 adult patients with cytogenetically poor risk acute myeloid leu... | In comparison with reduced intensity conditioning myeloablative conditioning MAC reduced leukemia related mortality and improved overall survival for patients with cytogenetically poor risk acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation HCT during first complete remission. In the subgro... |
S1083879119306378 | Patients undergoing hematopoietic stem cell transplantation are often admitted to the hospital the day they are due to begin their conditioning regimen . Timely initiation of chemotherapy during regular work hours is important for patient safety because during the night shift fewer physicians and pharmacists are availa... | Initiating chemotherapy during regular work hours is important for patient safety. Barriers to this are late admissions and time from admission to chemotherapy administration. Providing families with specific admission times and rationale improved admission times. Prompt nursing and pharmacy communication decreased tim... |
S108387911930638X | Critically ill pediatric allogeneic hematopoietic cell transplant patients may benefit from early and aggressive interventions aimed at reversing the progression of multiorgan dysfunction . Therefore we evaluated 25 early risk factors for pediatric intensive care unit mortality to improve mortality prognostication . We... | Critically ill pediatric allogeneic hematopoietic cell transplant HCT patients may benefit from early and aggressive interventions aimed at reversing the progression of multiorgan dysfunction. Using a multicenter cohort of 936 critically ill pediatric allogeneic HCT patients across 77 intensive care units this study id... |
S1083879119306391 | Cytomegalovirus reactivation and natural killer cell reconstitution are well recognized immunologic events occurring after allogeneic stem cell transplantation . We aimed to study the outcome of CMV reactivation and NK cell reconstitution in patients with hematologic malignancies after allo SCT . We retrospectively stu... | Post transplant cytomegalovirus CMV reactivation is associated with nonrelapse mortality and overall survival. A natural killer NK cell subset significantly contributed to a lower cumulative incidence of relapse. NK cell reconstitution improved post transplant outcomes especially in patients with CMV reactivation. |
S1083879119306470 | An open label phase 2 study of topical dexamethasone versus tacrolimus solutions in new onset oral chronic graft versus host disease revealed the superior efficacy of dexamethasone . The objective of this study was to report long term patterns of topical therapy utilization and clinical outcomes in this cohort after co... | More than 40 of patients were still being treated with topical therapy for oral chronic graft versus host disease cGVHD at 24 months after the initiation of oral topical therapy. Topical therapies were often switched between follow ups. Clinician reported National Institutes of Health oral mucosal score 0 12 median imp... |
S1083879119306482 | Post transplantation cyclophosphamide reduces the risks of severe acute and chronic graft versus host disease after allogeneic hematopoietic cell transplantation . Yet the standard clinical dose and timing of PTCy were partly extrapolated from MHC matched skin allografting models and were partly empirical . Here we inv... | The dose timing and cumulative exposure of post transplantation cyclophosphamide all are critical for its efficacy. The maximal efficacy of post transplantation cyclophosphamide peaks at day 4. Effective dosing schema reduce alloreactive conventional CD4. T cell proliferation and allow preferential regulatory T cell re... |
S1083879119306512 | Allogeneic hematopoietic stem cell transplantation can be curative for patients with hematologic malignancies . The ideal conditioning regimen before allo HSCT has not been established . We conducted a Phase II study to evaluate the tolerability and efficacy of clofarabine and treosulfan as conditioning regimen before ... | This Phase II study evaluated the tolerability and safety of a clofarabine and treosulfan conditioning regimen before allogeneic hematopoietic stem cell transplantation. We found a low incidence of severe hepatic toxicities such as veno occlusive disease. Disease relapse represent a major issue mainly for patients with... |
S1083879119306524 | Optimal administration of busulfan is hampered by variable and unpredictable drug metabolism in individual patients . At our institution Bu was previously administered with fixed weight based dosing in combination with cyclophosphamide and etoposide for patients with non Hodgkin lymphoma undergoing autologous stem cell... | Previous studies have shown that pharmacokinetic PK directed therapeutic dose monitoring TDM of i.v. administered busulfan results in a larger proportion of patients receiving desired busulfan exposure. Comparison of PK directed dosing of busulfan as part of preparative regimen for autologous stem cell transplantation ... |
S1083879119306536 | Although autologous hematopoietic cell transplantation is standard therapy for patients with lymphoma and multiple myeloma few studies have addressed late effects and quality of life in long term survivors after AHCT . Using long term follow up annual questionnaires with self reported outcomes we surveyed 665 patients ... | Patient undergoing autologous hematopoietic cell transplantation AHCT for lymphoma reported better health and quality of life QoL compared with those undergoing AHCT for multiple myeloma. At a median of 11 years after AHCT we identified important late effects and QoL deficits that are potentially amenable to interventi... |
S1083879119306548 | Our current knowledge of idiopathic pneumonia syndrome predates improved specificity in the diagnosis of IPS and advances in hematopoietic cell transplantation and critical care practices . In this study we describe and update the incidence risk factors and outcomes of IPS . We performed a retrospective cohort study of... | The incidence of idiopathic pneumonia syndrome IPS is declining in a modern cohort of allogeneic hematopoietic cell transplantation HCT recipients. Total body irradiation dose remains a significant risk factor for IPS development. IPS is a rare but substantial cause of post HCT morbidity and mortality. |
S108387911930655X | It remains unclear whether the HLA haplotype of unrelated cord blood should be matched to that of the patient in single UCB transplantation . Thus using data from a Japanese registry we analyzed the effect of haplotype matching on outcomes . Patients with hematologic diseases aged 16 years or older who had undergone th... | It is better to match the HLA haplotype to improve neutrophil and platelet engraftment in single UCBT. Two haplotype matches should be avoided if the relapse risk is high. The haplotype itself may have an effect on the risk of acute GVHD and relapse after UCBT. |
S1083879119306561 | This study aimed to investigate time varying effects of graft type on outcomes for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant . For this purpose we analyzed 3952 patients 720 of whom underwent matched related bone marrow transplantation 1004 matched related peripheral blood... | This study aimed to investigate time varying effects of graft type on allogeneic HCT outcomes for AML. RFS and OS were worse for related PBSCT and UCBT than for related BMT. Adverse impact of UCBT was observed only during the early phase of transplant. Adverse impact of related PBSCT continued even after 2 years post t... |
S1083879119306573 | CD19 targeted chimeric antigen receptor modified T cell immunotherapy is a novel treatment with promising results in patients with relapsed refractory lymphoid malignancies . CAR T cell therapy has known early toxicities of cytokine release syndrome and neurotoxicity but little is known about long term neuropsychiatric... | Overall long term survivors after chimeric antigen receptor CAR T cell therapy report good mental health. A subset of patients may experience psychiatric symptoms or cognitive impairment. Allogeneic hematopoietic cell transplantation before or after CAR T cells does not affect long term mental health. Older age is asso... |
S1083879119306597 | Large series of patients with acute myelogenous leukemia after ex vivo T cell depleted allogeneic hematopoietic stem cell transplantation have not been reported previously . We retrospectively analyzed the outcomes of 266 patients with AML who received CD34 selected TCD allo HSCTs while in first or second complete remi... | Ex vivo T cell depleted TCD hematopoietic stem cell transplantation HSCT in patients with acute myelogenous leukemia AML in first or second complete remission CR1 CR2 is associated with comparable overall survival and disease free survival to unmodified HSCT. Transplantation outcomes are similar in patients with AML CR... |
S1083879119306603 | Mixed chimerism and or secondary graft failure with recipient or donor type chimerism is a major obstacle in allogeneic transplantation for aplastic anemia . From a registry database in Japan patients with AA age 15 years who underwent a first allogeneic bone marrow or peripheral blood stem cell transplantation between... | The influence of mixed chimerism MC and or secondary graft failure SGF in hematopoietic stem cell transplantation for aplastic anemia was retrospectively evaluated. SGF with both MC recipient and donor type chimerism was observed. Patients who developed SGF with both types of chimerism had unfavorable outcomes. The use... |
S1083879119306615 | Patients undergoing allogeneic stem cell transplantation usually require nutritional support . There is no consensus on whether enteral support through tube feeding should be preferred . A recent randomized study could not detect any difference between enteral and parenteral feeding with regard to post transplant outco... | The type of nutritional support seems to have relatively minor effects on the post transplant metabolomic profile. The metabolic profile of patients treated with standard care nutritional support indicates an insufficient calorie intake compared with patients treated with individualized enteral nutritional support. |
S1083879119306627 | Hematopoietic stem cell transplantation recipients are vulnerable to invasive pneumococcal disease with reported IPD rates ranging from 3.81 to 22.5 1000 HSCT . This IPD risk could relate to immunodeficiency low vaccination uptake and poor immunogenicity of pneumococcal polysaccharide vaccine . Literature comparing the... | Hematopoietic stem cell transplantation HSCT recipients have high rates of invasive pneumococcal disease IPD . Patients with multiple myeloma are at particularly higher risk of IPD following HSCT. Compared with pneumococcal polysaccharide vaccine pneumococcal conjugate vaccine significantly reduced IPD in HSCT recipien... |
S1083879119306639 | Allogeneic hematopoietic stem cell transplantation is widely performed in children and adolescents with hematologic diseases including very high risk leukemia . With increasing success and survival rates the long term sequelae of HSCT have become important . Here we provide guidance to the prevention and treatment of t... | Bone mass deficits in children with leukemia following hematopoietic stem cell transplantation HSCT are multifactorial. Attention is needed for children with less potential to recover from low bone mineral density. Risk factors for osteonecrosis ON include older age at HSCT steroids chronic graft versus host disease an... |
S1083879119306652 | Despite the fact that the choice of donors and the number of sources of hematopoietic stem cells have increased a sibling remains a preferred donor for allogeneic hematopoietic stem cell transplantation . Transplant donation between siblings is a unique life experience that may have an impact on their future relationsh... | Quality of life in adult patients after hematopoietic stem cell transplantation in childhood was good. Sibling donor recipient relationship is unbalanced with higher level of rivalry presented among donors. Further multicenter studies are necessary to assess all aspects of sibling relationship years after transplantati... |
S1083879119306688 | Vitamin D deficiency is a well described phenomenon in pediatric patients undergoing hematopoietic stem cell transplant . VD modulates inflammation and deficiency pre HSCT and at day 100 has been associated with graft versus host disease and poorer survival . However a paucity of data has specifically described the ass... | Pediatric patients receiving HSCT have high risk of vitamin D insufficiency 61 . Substantial variation exists in vitamin D monitoring and supplementation practices. Pre HSCT vitamin D levels were not associated with incidence of GVHD or VOD. Higher vitamin D levels were associated with decreased risk for all cause mort... |
S108387911930669X | There are more than 30 million potential unrelated hematopoietic progenitor cell donors listed on international registries but 30 to 50 are unavailable after matching a patient . In the United States racial ethnic minorities opt out of donation at higher rates and a previous study identified factors associated both wit... | Potential HPC donors who opted out were more ambivalent and had more concerns. Potential HPC donors who opted out reported less interaction with the registry. Sixteen percent said more interaction with the registry would have changed their decision. Minorities reported more religious objections and mistrust about HPC a... |
S1083879119306706 | The utility of surveillance imaging after autologous hematopoietic cell transplantation in relapsed refractory diffuse large B cell lymphoma remains unclear . The purpose of this study was to determine whether surveillance imaging predicts survival after AHCT . At the University of Minnesota serial imaging for early re... | Routine PET imaging at day 100 post autologous HCT detects asymptomatic relapse in about 30 of patients with DLBCL and portents worse survival. High SUV. at day 100 PET is associated with survival of less than 1 year post transplant. Identifying this high risk cohort in autologous HCT recipients highlights the opportun... |
S1083879119306718 | In this prospective randomized study we compared the outcomes of single unit umbilical cord blood transplantation and unmanipulated haploidentical stem cell transplantation with post transplantation cyclophosphamide in adults with hematologic malignancies . All patients received a myeloablative conditioning regimen con... | Myeloablative haploidentical stem cell transplantation with post transplantation cyclophosphamide provides improved outcomes compared with antithymocyte globulin containing single unit umbilical cord blood transplantation. Some 15 of patients lacked an appropriate haploidentical donor. |
S108387911930672X | Allogeneic hematopoietic stem cell transplantation remains the only potentially curative option for myelodysplastic syndromes but is severely limited by nonrelapse mortality especially in this mostly older population . Comorbidity assessment is crucial to predict NRM and often assessed with the Hematopoietic Cell Trans... | Allotransplant for myelodysplastic syndrome is limited by high nonrelapse mortality. Comorbidities assessed by the original Sorror score impact mortality negatively. Chronological age also continues to play an independent prognostic role on mortality. Both age and comorbidities should be integrated in the allotransplan... |
S1083879119306731 | Killer immunoglobulin like receptor and KIR ligand interactions play an important role in natural killer cell mediated graft versus leukemia effect following hematopoietic cell transplantation . However there is considerable heterogeneity in the KIR gene and KIRL content in individuals making it difficult to estimate t... | An adaptive mathematical model has been developed to quantify killer immunoglobulin like receptor KIR KIR ligand KIRL interactions. The magnitude of inhibitory and missing KIR KIRL interactions predicts overall survival and relapse risk following HLA matched unrelated donor URD hematopoietic cell transplantation HCT . ... |
S1083879119306755 | Hematopoietic stem cell transplantation has been used to treat many malignant and nonmalignant hematologic conditions however the use of HSCT in patients who refuse blood transfusions has rarely been described in the literature and no data have been published concerning haploidentical HSCT without the use of blood prod... | Bloodless bone marrow transplantations were performed without treatment related mortality. There are no previously published data on haploidentical transplantation without blood products. Transplantation without transfusion can be used in other conditions without hemotherapy support. |
S1083879119306767 | Chronic graft versus host disease is a heterogenous syndrome whose symptoms and treatment are often associated with decreases in functional status and quality of life among survivors of transplantation . We explored definitions of cGVHD related disability and factors associated with disability in cGVHD . We analyzed 37... | Disability as defined by progressive chronic graft versus host disease GVHD impairments are associated with decline in human activity profile scores and performance status at 18 months. Worse oral scores and patient reported eye and skin scores are significantly associated with progressive chronic GVHD impairment at 18... |
S1083879119307049 | Methotrexate in combination with a calcineurin inhibitor has been commonly used for prophylaxis of graft versus host disease following umbilical cord blood transplantation in Japan . However the appropriate prophylactic MTX dosage in UCBT has not been established to date . To determine the preferential GVHD prophylaxis... | In this comparative analysis of 2 day and 3 day methotrexate MTX administration in umbilical cord blood transplantation UCBT. the very short term vs MTX tacrolimus TAC group had earlier neutrophil engraftment compared with the short term MTX TAC group. In a high risk population vsMTX TAC was associated with lower relap... |
S1083879119307050 | Acute graft versus host disease is a major complication following hematopoietic cell transplantations . We have shown that HCT recipients in whom either the donor or patient had inherited chromosomally integrated human herpesvirus 6 have a higher incidence of developing more severe aGVHD . Previous studies established ... | Hematopoietic cell transplantation HCT recipients in whom the donor or recipient had inherited chromosomally integrated human herpesvirus 6 iciHHV 6. have higher plasma C reactive protein and TNFRp55 cytokine concentrations. IciHHV 6. HCT recipients had earlier onset graft versus host disease by a median of 7 days. The... |
S1083879119307062 | fludarabine with intravenous busulfan at doses of 3.2 mg kg or 6.4 mg kg . Hepatic veno occlusive disease sinusoidal obstruction syndrome is a serious complication of hematopoietic stem cell transplantation that is felt to be triggered at least in part by damage to the liver sinusoidal endothelium from cytotoxic condit... | Veno occlusive disease sinusoidal obstruction syndrome VOD SOS is rare after reduced intensity conditioning RIC transplantation with a cumulative incidence of 1.6 in our large modern cohort. VOD SOS continues to be associated with a high nonrelapse mortality NRM in our cohort day 100 NRM was 23 in patients with VOD SOS... |
S1083879119307074 | Azithromycin exposure during the early phase of allogeneic hematopoietic cell transplantation has been associated with an increased incidence of hematologic relapse . We assessed the impact of azithromycin exposure on the occurrence of relapse or new subsequent neoplasm in patients with bronchiolitis obliterans syndrom... | Azithromycin is associated with increased second cancers in bronchiolitis obliterans. Azithromycin is not associated with increased relapse in bronchiolitis obliterans. There is a decreased cause specific hazard of death free of malignancy with azithromycin exposure. |
S1083879119307086 | Although thymus independent donor derived T cell expansion may determine the occurrence of graft versus host disease and relapse after transplantation the characteristics and dynamics of the expansion process remain unclear . To address this issue we monitored T cell receptor repertoire at day 0 day 28 and day 61 after... | Homeostatic peripheral expansion predominates in the first month after allogeneic hematopoietic stem cell transplantation. Antigen driven expansion in the second month leads to a graft versus tumor GvT effect. TCRI200bc 1.0 indicates a potent GvT effect and freedom from relapse within a year. The GvT associated clones ... |
S1083879119307098 | Outbreaks of viral infections such as measles are regularly observed and pose a serious threat to recipients of allogeneic hematopoietic cell transplantation . The questions of how long cellular and humoral protective host immunity persists and whether donor immunity can be transferred has not been clarified . Here we ... | Loss of protective antibody levels over time differed substantially between measles mumps and rubella in patients following allogeneic hematopoietic cell transplantation HCT . Protective immunity against measles and rubella that was acquired by wild type viral infection persisted longer than immunity due to vaccination... |
S1083879119307104 | Acute graft versus host disease contributes to poor outcomes following allogeneic hematopoietic cell transplantation . Data are limited regarding the economic burden of acute GVHD particularly steroid refractory or high risk disease . This retrospective analysis of the Premier Healthcare Database reports inpatient heal... | Inpatient healthcare resource utilization HCRU and costs for acute versus no graft versus host disease GVHD up to 100 days post hematopoietic cell transplantation HCT were assessed. Acute GVHD was associated with greater inpatient HCRU and total costs compared with no GVHD. Inpatient HCRU and costs were especially high... |
S1083879119307116 | Allogeneic stem cell transplant is considered in diffuse large B cell lymphoma patients with chemorefractory disease or who have relapsed after autologous SCT . Here we present the first report of alloSCT using the R BEAM conditioning regimen in DLBCL patients . | Allogeneic transplant is a viable treatment in diffuse large B cell lymphoma. The R BEAM regimen is associated with significantly higher grades III to IV acute GVHD. Nonrelapse mortality is substantial. A few patients attain a durable response indicating a graft versus lymphoma effect. |
S108387911930713X | Basiliximab has been used successfully as a second line treatment for steroid refractory acute graft versus host disease in adult patients after haploidentical hematopoietic stem cell transplant but has not been studied separately in the pediatric setting . We retrospectively reviewed 100 pediatric patients after haplo... | This study represents the first report on the outcomes of basiliximab as a treatment for steroid refractory SR acute graft versus host disease aGVHD in pediatric patients after allo HSCT. The overall response rate of basiliximab was 85 including complete response in 74 and partial response in 11 . No life ending compli... |
S1083879119307141 | Natural killer cells expressing killer cell immunoglobulin like receptors can recognize specific HLA class I molecules as their ligands . By studying a large Japanese transplant registry we compared transplant outcomes between patients heterozygous for HLA C | Absence of KIR2DL1 ligands increases relapse in HLA matched hematopoietic stem cell transplantation HSCT for acute lymphoblastic leukemia ALL . This trend is prominent in patients with Ph negative ALL who experienced acute graft versus host disease. The trend is the opposite of that in our previous report analyzing HSC... |
S1083879119307414 | The impact of allele level HLA mismatch on outcomes of cord blood transplantation has not been well established . We retrospectively analyzed the effects of HLA allele matching at HLA A B C and DRB1 in cord blood transplantation for acute myeloid leukemia acute lymphoblastic leukemia and myelodysplastic syndrome . In m... | HLA A B C and DRB1 allele mismatch effects were examined in 4050 cases of cord blood transplants. Overall survival OS deteriorated in HLA 5 allele and higher mismatch in adult cord blood transplantation CBT . OS deteriorated in HLA 4 allele and higher mismatch in pediatric CBT. In adult cases 8 8 match mitigated severe... |
S1083879119307426 | Torque teno virus is a nonenveloped single stranded circular DNA virus of the family of Anelloviridae . The first contact with TTV usually occurs in early childhood followed by persistent infection in bone marrow and lymphocytes . Increased levels of TTV DNA are found in the serum in various states of immune deficiency... | A multifactorial influence determines the level and kinetics of torque teno TT viral load. Numerous new influencing factors were identified. Significant differences were only visible after day 50 after allogeneic hematopoietic stem cell transplantation. Clinically relevant events showed no significant impact on TT vira... |
S1083879119307438 | Follow up is integral for hematopoietic cell transplantation care to ensure surveillance and intervention for complications . We characterized the incidence of and predictors for being lost to follow up . Two year survivors of first allogeneic HCT or autologous HCT for malignant nonmalignant disorders between 2002 and ... | Follow up is an integral part of hematopoietic cell transplantation HCT care. We characterized the incidence of and predictors for being lost to follow up. The proportion of HCT survivors lost to follow up is concerning. Subgroups of HCT survivors remain at higher risk of being lost to follow up. Follow up efforts focu... |
S108387911930744X | The significant advancements made in the field of allogeneic hematopoietic stem cell transplantation have ensured increased longevity in transplant recipients . However they do have late effects that may adversely affect the endocrine system bone health and body composition . This study was undertaken to evaluate bone ... | The mean femoral neck bone mineral density BMD was lower in recipients of allogeneic hematopoietic stem cell transplantation. Myeloablative conditioning had an adverse effect on BMD at the femoral neck. Lumbar spine BMD was lower in the group that received total body irradiation. The prevalence of sarcopenia was signif... |
S1083879119307451 | Cytomegalovirus results in significant morbidity and mortality following hematopoietic cell transplantation . Establishing the cost and clinical impact is imperative to the selection of appropriate CMV preventative strategies . This is a retrospective cohort study of consecutive patients undergoing their first allogene... | Cytomegalovirus following transplantation carries significant morbidity and mortality. Implementation of efficacious preventative strategies is imperative. Strategy selection requires an assessment of the economic impact of cytomegalovirus. |
S1083879119307475 | Radioimmunotherapy has the potential to reduce the incidence of relapse after allogeneic hematopoietic cell transplantation in patients with advanced stage multiple myeloma . In this study we evaluated the efficacy of RIT in combination with chemotherapy based reduced intensity conditioning . RIT was based on the coupl... | Radioimmunotherapy RIT is a novel concept for conditioning in patients with multiple myeloma MM . CD66 directed RIT was combined with reduced intensity conditioning RIC . The CD66 RIT RIC strategy is safe and feasible for patients with MM. The combined therapy results in promising outcomes after allogeneic hematopoieti... |
S1083879119307487 | Allogeneic blood or marrow transplantation remains the only treatment for chronic lymphocytic leukemia with curative potential . Although post transplantation cyclophosphamide reduces allo BMT toxicity by decreasing the risk of graft versus host disease its effect on CLL allo BMT outcomes is unknown . We studied 64 con... | Outcomes of haploidentical allogeneic bone marrow transplantation allo BMT may be similar to those reported for matched donor allo BMT in patients with chronic lymphocytic leukemia CLL . Post transplantation cyclophosphamide prophylaxis is associated with low rates of acute and chronic graft versus host disease. Pre al... |
S1083879119307505 | There have been sporadic reports of the development of delayed disease recurrence after bone marrow transplantation for severe aplastic anemia despite sustained majority or full donor chimerism . This is termed donor type aplasia . We describe the management and outcome of 11 pediatric patients from 8 institutions in E... | DTA is recurrent pancytopenia despite sustained majority donor chimerism after BMT for SAA. Treatment with immunosuppressive therapy or stem cell boosts has not been effective. Most patients required retransplantation from the same or an alternative donor. Sibling retransplantation has sometimes been followed by furthe... |
S1083879119307797 | We compared the incidence of refractory thrombocytopenia and platelet transfusion requirements in 35 children who developed veno occlusive disease with 35 matched control subjects who underwent hematopoietic stem cell transplant but did not develop VOD . RT developed in 100 of the VOD patients at a median of 8 days bef... | Refractory thrombocytopenia is a valid and early diagnostic criteria for VOD in children as included in the 2017 EBMT criteria. RT occurs in 100 of the patients with VOD at a median of 8 days before VOD diagnosis. Platelet transfusion requirements in VOD patients is higher than in the patients who do not develop VOD. T... |
S1083879119307815 | Hematopoietic stem cell transplantation is a primary treatment for various inherited metabolic disorders . Achieving stable and sustained engraftment while minimizing transplantation related morbidity and mortality is critical to optimizing outcomes for IMDs . Traditional regimens have used myeloablative approaches pri... | BuCy based conditioning is associated with greater regimen related toxicity but earlier CD3 donor engraftment. BuFlu based conditioning is associated with lower toxicity but higher rates of graft failure and immune cytopenias. Newer approaches and modification of conditioning regimen are needed to optimize benefits. |
S1083879119307827 | Anti thymocyte globulin is an established approach to decrease chronic GVHD yet the exact mechanism is uncertain . To better understand the mechanism of action of ATG in preventing cGVHD we evaluated the day 100 immune reconstitution of known cGVHD cellular biomarkers using patients from the randomized Canadian Bone Ma... | Chronic graft versus host disease cGVHD marker utilization in clinical trials can elucidate the mechanisms of action. Anti thymocyte globulin ATG suppresses naive Th cell populations and expansion of CD56. natural killer cells. ATG primarily impacts on cGVHD through suppression of naive Th cells. |
S1083879119307839 | Umbilical cord blood transplantation is a curative procedure for patients with hematologic malignancies and genetic disorders and expands access to transplantation for non Caucasian patients unable to find a fully matched unrelated donor . In 2011 the US Food and Drug Administration required that unrelated UCBT be perf... | Unlicensed umbilical cord blood units can be safely and effectively used for hematopoietic cell transplantation HCT in adult and pediatric patients. Unlicensed umbilical cord blood expands access to racially ethnically diverse patients in need of HCT. Further studies are required to compared licensed and unlicensed umb... |
S1083879119307852 | Allogeneic hematopoietic cell transplant may improve long term multiple myeloma control through the graft versus myeloma effect . The Blood and Marrow Transplant Clinical Trials Network 0102 trial was a biologic assignment trial comparing tandem autologous transplant versus autologous followed by reduced intensity allo... | Long term follow up of auto auto versus auto allo in newly diagnosed multiple myeloma patients confirms significant and durable reduction in risk of relapse with the auto allo approach. Auto allo transplant is associated with better 6 year PFS for high risk patients. Patients who relapsed after auto allo had longer pos... |
S1083879119307864 | Polyphenols are a group of chemical substances found in plants with immunomodulatory antiproliferative and anti inflammatory properties that might be useful in the prophylaxis and treatment of graft versus host disease . Polyphenolic extract obtained from extra virgin olive oil decreased the activation and proliferatio... | Polyphenolic extract PE decreased activation IL 2 and TNF secretion and AKT P and NF B in T cells. A PE supplemented diet decreased acute graft versus host disease risk and improved survival in a mice model. A decrease in IL 2 IL 17 and TNF secretion was observed among mice receiving PE. Feces butyrate concentration wa... |
S1083879119307876 | Chronic graft versus host disease adversely affects patient quality of life functional status and survival after allogenic hematopoietic cell transplantation . The Lee Symptom Scale is a 30 item scale developed to measure the symptoms of cGVHD . Although the original 30 item scale uses a 1 month recall period we tested... | The 28 item modified Lee chronic GVHD symptom scale mLSS is valid and reliable. The scale takes 2 minutes to complete a 5 to 6 point difference is clinically meaningful. |
S1083879119307888 | After autologous hematopoietic cell transplantation in the first complete remission patients with acute myeloid leukemia may relapse and undergo allogeneic HCT in the second complete remission . The aim of this study was to analyze the outcome of allogeneic HCT performed in CR2 comparing patients with prior consolidati... | Nonrelapse mortality after prior autologous hematopoietic cell transplantation HCT for subsequent allogeneic HCT in the second complete remission. Conditioning toxicity. Consolidation of acute myeloid leukemia in complete remission 1 by autologous HCT |
S1083879119308158 | Most children who may benefit from stem cell transplantation lack a matched related donor . Alternative donor transplantations with an unrelated donor or a partially matched related donor carry an increased risk of graft versus host disease and mortality compared with matched related donor transplantations . We hypothe... | The study cohort comprised children with leukemia who underwent partially CD3. depleted peripheral stem cell transplantation PSCT . Three year overall survival was 61.8 95 confidence interval CI 50.2 to 71.4 and event free survival was 52.0 95 CI 40.3 to 62.4 . Age 15 years and second complete remission were associated... |
S108387911930816X | Allogeneic hematopoietic cell transplantation is a demanding treatment with well established medical and psychosocial sequelae . Impacts on significant others are tremendous . Using an unfiltered qualitative approach we asked spouses of HCT recipients to talk about their thoughts and feelings regarding the transplantat... | Caregivers mentioned a preponderance of negative psychological impacts. The most common negative psychological impacts were anxiety fear feeling overloaded overwhelmed and uncertainty. Despite these impacts a picture of resilience emerged with caregivers mentioning coping in adaptive ways such as using of emotional sup... |
S1083879119308316 | Corneal clouding causing visual impairment is seen in nearly all patients with mucopolysaccharidosis type 1 . Hematopoietic cell transplantation is able to stabilize disease in many organs . Residual disease in several tissues is being increasingly recognized however . Data on the effect of HCT on ocular disease in pat... | After initial stabilization corneal clouding is progressing in patients with mucopolysaccharidosis type 1 MPS 1 after treatment with hematopoietic cell transplantation HCT . Best corrected visual acuity is also worsening in MPS 1 patients after treatment with HCT. Despite normalized hematologic L iduronidase IDUA activ... |
S1083879119308328 | Sinusoidal obstruction syndrome is a well recognized and potentially life threatening complication of hematopoietic stem cell transplantation . SOS arises from endothelial cell damage and hepatocellular injury mostly due to the transplantation conditioning regimens but also to other patient disease and treatment relate... | Sinusoidal obstruction syndrome SOS is a complication of hematopoietic stem cell transplantation. Whole exome sequencing was performed to identify the genetic contribution to SOS. Exome wide association study identified 8 lead signals in the discovery cohort. Three loci. and. were validated in the replication group. Th... |
S108387911930833X | Chimeric antigen receptor T cell therapy a new immunotherapy for relapsed and refractory hematologic malignancies can be accompanied by adverse events including coagulation disorders . Here we performed a comprehensive analysis of coagulation parameters in 100 patients with R R hematologic malignancies after receiving ... | A high incidence of coagulation disorders was observed after chimeric antigen receptor CAR T cell therapy infusion. The changes of coagulation parameters were associated with cytokine release syndrome CRS . Disseminated intravascular coagulation was found in patients with severe CRS and indicated a poor prognosis. Coag... |
S1083879119308341 | In this retrospective analysis we evaluated the impact of age on the outcome of patients with multiple myeloma who received an autologous hematopoietic stem cell transplantation at our institution . A total of 1128 patients were divided into the older and the younger groups . Compared with the younger cohort older pati... | This retrospective analysis compares the outcome of patients with newly diagnosed multiple myeloma NDMM aged 70 versus 70 years n 1128 . Age cutoff at 70 years is higher than in most other retrospective studies that performed a similar analysis. There is an association between age at transplantation with progression fr... |
S1083879119308353 | Hematopoietic stem cell transplantation is the only curative treatment for juvenile myelomonocytic leukemia but few large studies of HSCT for JMML exist . Using data from the Japan Society for Hematopoietic Cell Transplantation registry we analyzed the outcomes of 129 children with JMML who underwent HSCT between 2000 ... | Hematopoietic cell transplantation is the only curative therapy for juvenile myelomonocytic leukemia. Busulfan fludarabine melphalan seems to offer the best chance of long term survival. Chronic graft versus host disease correlates with improved survival by reducing relapse. Treatment strategies enhancing graft versus ... |
S1083879119308377 | Bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation is often diagnosed at a late stage when lung dysfunction is severe and irreversible . Identifying patients early after transplantation may offer improved strategies for early detection that could avert the morbidity and mortality of B... | Identifying patients at risk for bronchiolitis obliterans syndrome BOS after allogeneic hematopoietic cell transplantation may offer improved strategies for early detection. Declines in pretransplantation and early post transplantation spirometric parameters are associated with risk of developing BOS. A reduction in FE... |
S1083879119308389 | Prolonged thrombocytopenia after hematopoietic stem cell transplantation is a strong risk factor for transplantation related morbidity and mortality and no standard treatment guideline exists . Thrombopoietin receptor agonists eltrombopag and romiplostim increases the platelet production and are being increasingly used... | Prolonged thrombocytopenia after hematopoietic stem cell transplantation HSCT is a strong risk factor for transplantation related morbidity and mortality. No common consensus exists for the uniform classification and management of prolonged thrombocytopenia after HSCT. The available literature inconsistently describes ... |
S1083879119308390 | Allogeneic hematopoietic stem cell transplantation is the only available curative treatment option for patients with aggressive adult T cell leukemia lymphoma . Donor human T cell leukemia virus 1 seropositivity is a critical concern when choosing relative donors as they are not usually recommended due solely to the oc... | We assessed the effect of donor human T cell leukemia virus 1 serostatus on outcomes of allogeneic hematopoietic stem cell transplantation allo HCT in adult T cell leukemia lymphoma. There was no significant difference in overall survival or incidence of mortality. This might aid the choice of appropriate and timely al... |
S1083879119308675 | Congenital erythropoietic porphyria is a rare disease characterized by erosive photosensitivity and chronic hemolysis due to a defect of the enzyme uroporphyrinogen III synthase . To date hematopoietic stem cell transplantation is the only curative therapy for the devastating early and severe form of the disease . We d... | The very first still living recipients of hematopoietic stem cell transplantation HSCT for early and severe forms of congenital erythropoietic porphyria CEP 25 and 22 years ago are healthy and asymptomatic with sustained corrected uroporphyrinogen III synthase activity. Intrinsic hepatic involvement of varying intensit... |
S1083879119316507 | Acute pancreatitis has been recognized as an uncommon yet potentially lethal complication after hematopoietic stem cell transplant . This retrospective nested case control study reviewed data from 5284 consecutive patients who underwent allogeneic HSCT between 2009 and 2018 at a single center identifying 40 patients wi... | We report the incidence of acute pancreatitis AP after allo HSCT. We identify younger age grades II to IV aGVHD a history of DLI and pre existing gallstones as independent risk factors of post transplant AP. We describe the outcomes of patients with post transplant AP. We establish an exploratory risk score model to he... |
S1083879119316519 | Antibiotic induced gut dysbiosis has been associated with poor outcomes after intensive therapy . We evaluated the effect of levofloxacin the most commonly used prophylactic antibacterial antibiotic during intensive chemotherapy and allogeneic hematopoietic cell transplantation on the gut microbiota in 2 cohorts of pat... | Prophylactic levofloxacin LEVO during intensive therapy did not reduce gut microbiota diversity. LEVO exposure was associated with a relative reduction of. LEVO exposure was associated with a relative expansion of |
S1083879119316520 | Patients with acute myelogenous leukemia who undergo killer immunoglobulin like receptor mismatched haploidentical hematopoietic stem cell transplantation have improved survival . Children s Oncology Group AAML05P1 is a prospective phase 2 trial of unrelated donor HSCT in which KIR typing of donors was available to the... | KIR mismatching did not improve disease free survival in children transplanted with unrelated donor stem cells for AML using in vivo T cell depletion with ATG. KIR mismatching did alter the kinetics of NK cell receptor acquisition on donor cells after stem cell transplantation in children. |
S1083879119316532 | Common respiratory viral infections frequently complicate hematopoietic stem cell transplantation . We conducted a retrospective single center observational cohort study to determine the incidence of CRVI in patients who received an allogeneic or autologous HSCT at the Royal Adelaide Hospital between 2009 and 2017 . Th... | Of HSCT recipients 10.4 experienced common respiratory viral infections CRVIs . Rhinovirus infection was common accounting for nearly 50 of CRVIs. Of CRVIs 45.6 were complicated by lower respiratory tract infection LRTI . Respiratory viral coinfection and cytomegalovirus viremia were risk factors for LRTI. Of CRVI epis... |
S1083879119316544 | This is a multicenter retrospective comparison of 2 myeloablative conditioning regimens in 454 patients with acute myeloid leukemia in remission busulfan and fludarabine versus thiotepa busulfan and fludarabine . Eligible for this study were patients allografted between January 2008 and December 2018 in 10 transplant c... | The combination of thiotepa and busulfan fludarabine reduces the risk of relapse in patients with remission acute myeloid leukemia compared with myeloablative busulfan fludarabine. The effect is independent of donor type and graft versus host disease prophylaxis. |
S1083879119317318 | Gemtuzumab ozogamicin therapy before allogeneic hematopoietic cell transplantation has been historically associated with an increased risk of hepatic veno occlusive disease sinusoidal obstruction syndrome in patients with acute myeloid leukemia . The current analysis examined VOD SOS risk and outcomes in a cohort of pa... | VOD SOS incidence at 100 days post HCT was 4 versus 3 in GO exposed adults versus control subjects. Five year overall survival probability was 38 in both groups. GO exposure before HCT was not associated with an increased risk of VOD SOS or death. |
S108387911931732X | Immunosuppressive drugs are an inherent component of hematopoietic stem cell transplantation for the prevention of acute graft versus host disease . Circulating 1 antitrypsin a serine protease inhibitor produced predominantly by hepatocytes that rises during acute phase responses is lost in patient s stool due to gastr... | Rapamycin decreases 1 antitrypsin production by hepatocytes under inflammation. Mycophenolate mofetil inhibits wound repair in intestinal epithelial cell line. Exogenous 1 antitrypsin enhances allo HSCT recipients sera wound repair capability. |
S1083879119317331 | HLA haploidentical allogeneic hematopoietic cell transplantation using post transplantation cyclophosphamide is becoming the standard of care for patients without an HLA matched related or unrelated donor . PT Cy haplo can give more patients the opportunity to undergo allo HCT because most patients have multiple availa... | Donor. was associated with reduced risk of relapse after HLA haploidentical allogeneic hematopoietic cell transplantation allo HCT using post transplantation cyclophosphamide PT Cy haplo . Donor. was associated with improved overall survival with PT Cy haplo. GVL effect via NK cell alloreactivity was exerted in CR but ... |
S1083879119317343 | Reduced intensity conditioning regimens improved HLA matching and better supportive care allow allogeneic stem cell transplant to be offered to older patients . Only a small percentage of eligible patients between ages 65 and 74 years actually undergo alloSCT and comprehensive outcome data from the aging population are... | Older patients with hematologic malignancies tolerate melphalan based RIC alloSCT with acceptable survival outcomes. Using. T cell depletion the incidence of cGVHD is very low and quality of life of survivors is excellent. Outcomes of related unrelated and haplo cord alloSCT are comparable. |
S1083879119317380 | Although cord blood transplantation extends allograft access patient comorbidities chemoradiation and nephrotoxic medications all contribute to acute kidney injury risk . We analyzed AKI in adult myeloablative CBT recipients who underwent transplantation from 2006 to 2017 for hematologic malignancies using cyclosporine... | Day 100 grade 2 to 3 acute kidney injury AKI incidence is high after adult cord blood transplantation. Grade 1 to 2 AKI can be present with a normal creatinine. A higher pretransplant serum albumin protects against AKI. Critical illness and nephrotoxic drugs increase AKI risk. Early post transplant AKI increases 2 year... |
S108387912030001X | Extracorporeal photopheresis is an established treatment strategy in steroid refractory graft versus host disease . This study s main objective was to analyze the clinical response and impact of ECP therapy in steroid dose reduction . A retrospective observational series of 113 patients from 7 transplantation centers w... | Photopheresis is an effective treatment for refractory graft versus host disease GVHD . Overall response to treatment is the most important variable for survival. Gastrointestinal GVHD carries a worse prognosis and response. Steroid dose reduction is associated with improved survival in chronic GVHD. |
S1083879120300021 | The newly developed 6 hydroxychromanol derivate SUL 109 was shown to provide protection during hypothermic storage of several cell lines but has not been evaluated in hematopoietic stem cells . Hypothermic preservation of HSCs would be preferred over short term cryopreservation to prevent cell loss during freezing thaw... | SUL 109 a newly developed 6 chromanol derivate is an easy to use nontoxic cell culture additive that provides protection during hypothermic storage of hematopoietic stem cells HSCs . SUL 109 improves cell survival of immature CD34. CD38. cells during hypothermic storage and preserves the multilineage capacity of human ... |
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