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S1083879120303621 | Allogeneic hematopoietic stem cell transplantation remains an important treatment modality for patients with acute myeloid leukemia . Recent advances have extended donor availability for patients without matched donors . Transplantation is now increasingly offered to older patients including those above 70 years and le... | Reduced intensity conditioning increased the use of allogeneic hematopoietic stem cell transplantation allo HSCT to older patients with acute myeloid leukemia AML and those with comorbid conditions. Haploidentical donors expanded the availability of allo HSCT for patients with AML. Improved graft versus host disease pr... |
S1083879120303633 | Axicabtagene ciloleucel and tisagenlecleucel are autologous anti CD19 chimeric antigen receptor T cell therapies for the treatment of patients with relapsed refractory large B cell lymphoma . Both can induce durable responses however cross trial comparisons are difficult due to differences in study design . In this stu... | Direct cross trial comparison of axi cel ZUMA 1 and tisa cel JULIET chimeric antigen receptor T products is not feasible. Matching adjusted indirect comparison successfully adjusted for differences in patient characteristics between ZUMA 1 and JULIET. Axi cel had a higher objective response complete response and overal... |
S1083879120303657 | Veno occlusive disease sinusoidal obstruction syndrome is a potentially life threatening complication of hematopoietic cell transplantation . Early diagnosis and subsequently earlier intervention have been shown to be beneficial to clinical outcomes . Diagnostic criteria from the European Society for Blood and Marrow T... | Early detection and prompt treatment of veno occlusive disease sinusoidal obstruction syndrome VOD SOS are critical to optimal management. Recent criteria have suggested a role for imaging in diagnosing VOD SOS. Evidence supports the use of ultrasound to confirm diagnosis and monitor treatment. Ultrasound elastography ... |
S1083879120303669 | The Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup has organized an annual workshop focused on minimal residual disease testing and immune profiling in multiple myeloma since 2016 . In 2019 the workshop took place as an American Society of Hematology Friday Scientific Workshop titled Immune Prof... | A comprehensive summary of the 2019 BMT CTN Myeloma Intergroup Minimal Residual Disease MRD and Immune Profiling IP workshop is provided. MRD is a prognostic biomarker and should be incorporated into trial designs. IP provides insight into disease biology and response to treatment. |
S1083879120303670 | Immune checkpoint inhibitors are approved in relapsed classic Hodgkin lymphoma . The safety and effectiveness of allogeneic blood or marrow transplantation in ICI pretreated patients with cHL remain unclear . The aim of this study is to assess outcomes of patients with cHL receiving ICIs before alloBMT using post trans... | Immune checkpoint inhibition ICI before allogeneic bone marrow transplantation alloBMT does not increase risk of graft versus host disease in patients receiving post transplantation cyclophosphamide PTCy . ICI therapy before alloBMT with PTCy in patients with classic Hodgkin lymphoma may improve disease progression and... |
S1083879120303682 | Severe thalassemia syndromes are highly curable by bone marrow transplant but rejection may still occur . We retrospectively analyzed our fully matched related donor transplants to establish if isolated splenomegaly is an independent risk factor for rejection and if this risk can be reduced by modifying the conditionin... | Isolated splenomegaly may increase the risk of rejections in low risk thalassemia transplants. The rejection risk due to splenomegaly can be partially overcome by increasing immunosuppression in the conditioning regimen. |
S1083879120303694 | Chronic graft versus host disease remains a significant late effect issue for allogeneic hematopoietic cell transplantation survivors contributing to morbidity and mortality . The etiology of cGVHD is not well elucidated . Owing to a lack of early diagnostic tests and pathophysiology ambiguity targeted treatments remai... | Differential metabolite expression was noted in those discordant for chronic graft versus host disease cGVHD . cGVHD may be associated with expanded cellular energy. Metabolic perturbations may be useful to help characterize cGVHD. Serotonin may be a promising candidate biomarker of cGVHD. More research is needed to id... |
S1083879120303712 | The internet can be a valuable tool in delivering survivorship care to hematopoietic cell transplantation cancer survivors . We describe the reach of INSPIRE an Internet and social media based randomized controlled trial to address healthcare and psychosocial needs of HCT survivors . All survivors 2 10 years after HCT ... | The INSPIRE online intervention was accessible for a diverse group of HCT survivors. Only 7 did not have Internet and email access. A wide age range participated from 19 to 89 years. Higher enrollment rates were age 40 years allogeneic recipients Native American race. African American and male survivors were less likel... |
S1083879120303736 | Up to 40 of boys with adrenoleukodystrophy develop a severe central nervous system demyelinating form characterized by white matter changes and gadolinium enhancement on magnetic resonance imaging . Hematopoietic cell transplant is the only proven means to attenuate cALD progression . The elimination of active neuroinf... | Blood brain barrier disruption in cerebral adrenoleukodystrophy cALD is indicated by gadolinium enhancement. Gadolinium can be quantified on pre hematopoietic cell transplant HCT magnetic resonance imaging. Gadolinium volume pre HCT correlates to timing of gadolinium resolution after HCT. Early gadolinium resolution af... |
S1083879120303955 | Immune effector cell therapy is emerging as a promising approach in the field of cancer immunotherapy . Clinical IEC trials predominantly using chimeric antigen receptor T cells have shown excellent responses in CD19 | Chimeric antigen receptor T therapy for solid tumors has encountered challenges in early clinical trials. Toxicity antigen targeting trafficking and immune evasion hamper cell activity. Novel techniques are being explored to improve treatment safety and efficacy. |
S1083879120303967 | The use of cyclophosphamide for bidirectional tolerization of recipient and donor T cells is associated with reduced rates of graft versus host disease and nonrelapse mortality after HLA matched hematopoietic stem cell transplantation . However recurrent disease remains the primary barrier to long term survival . We ex... | There was high tolerance of radiation based myeloablative conditioning with cyclophosphamide. With the use of 3 GVHD prophylaxis agents relapse was a major barrier to survival. Doses of T cells not exposed to cyclophosphamide were associated with less relapse. |
S1083879120303979 | Reduced bone mineral density is a well recognized complication of hematopoietic cell transplantation with significant drops in BMD occurring within the first 12 months after HCT . Guidance on identifying and managing this complication is available in several published guidelines . In this study we investigated current ... | Low bone mineral density BMD is frequent after hematopoietic cell transplantation HCT . There is inconsistency of practice in relation to guidelines on BMD after HCT. There is a lack of familiarity with BMD guidelines among European HCT centers. |
S1083879120304006 | The aim of this study was to verify the feasibility of rabbit antithymocyte globulin in combination with 600 cGy of fractionated total body irradiation and fludarabine Flu 150 mg m | A regimen of fractionated total body irradiation 600 cGy fludarabine intermediate dose antithymocyte globulin 5 mg kg results in feasible outcomes. Donor type and comorbidities affected graft versus host diseasefree and failure free survival. Upfront application of haploidentical stem cell transplantation in patients w... |
S1083879120304018 | Graft versus host disease can manifest as acute or chronic complications in patients after hematopoietic cell transplantation . Oral chronic GVHD occurs in approximately 70 of HCT recipients and includes lichenoid like mucosal reactions restricted mouth opening and salivary gland dysfunction . However the underlying hi... | This is a large cohort analysis defining oral mucosal chronic graft versus host disease cGVHD histology. A formalized histological grading tool is described. Histology is correlated with clinical staging to define oral mucosal cGVHD criteria. Grades II to IV define pathological diagnostics of oral mucosal cGVHD. Patien... |
S108387912030402X | The timing of immunosuppressive therapy used in combination with post transplantation cyclophosphamide in haploidentical hematopoietic stem cell transplant is not standardized . We evaluated the schedules of immunosuppression therapy after haplo HSCT in 509 patients with acute leukemia receiving PTCY on days 3 and 4 al... | There is no standard schedule for post transplantation cyclophosphamide PTCY and associated immunosuppressors in recipients of haploidentical transplantation. Early introduction of cyclosporine A and mycophenolate mofetil with PTCY on days 3 and 5 results in better refined graft versus host disease free relapse free su... |
S1083879120304031 | Cytomegalovirus viremia occurs in 40 to 80 of CMV seropositive recipients of allogeneic hematopoietic cell transplantation . The preemptive therapy strategy has reduced the risk of CMV end organ disease and associated mortality but may lead to substantial healthcare resource utilization and costs . Real world data on t... | We evaluated the impact of cytomegalovirus CMV viremia managed with preemptive therapy PET on healthcare resource utilization after hematopoietic cell transplantation at a single center. In multivariable models CMV infection managed by PET was associated with increased readmissions and higher inpatient costs. CMV relat... |
S1083879120304043 | Various reduced intensity conditioning regimens are in use for allogeneic hematopoietic cell transplant in patients with idiopathic severe aplastic anemia . We describe the use of fludarabine Campath and low dose cyclophosphamide FCC | Fludarabine Campath and low dose cyclophosphamide FCC. and low dose total body irradiation for unrelated donor graft conditioning for allogeneic hematopoietic stem cell transplant HSCT in children with severe aplastic anemia SAA results in excellent cure rates. Use of peripheral blood stem cell source for alemtuzumab b... |
S1083879120304055 | There have been several efforts to predict mortality after autologous stem cell transplantation such as the hematopoietic cell transplant comorbidity index described for allogeneic stem cell transplantation and validated for ASCT but there is no composite score in the setting of ASCT combining comorbidities with other ... | Variables other than comorbidities affect nonrelapse mortality NRM after autologous transplant. We developed in a large cohort a novel score combining hematopoietic cell transplant comorbidity index age disease and sex. The new score predicts early morbidity events and long term NRM and overall survival. The score was ... |
S1083879120304067 | Although hematopoietic cell transplantation from an HLA matched unrelated donor is potentially curative for hematologic malignancies survival is lower for African Americans compared with Caucasians . Because only approximately 20 of African Americans will have an HLA matched unrelated donor many of these patients under... | The use of HLA haploidentical and umbilical cord blood transplants expands the access to transplantation is regardless of patient race or ethnicity. The risk of grade II IV and III IV acute graft versus host disease is increased after umbilical cord blood transplantation. The risk of transplantation related mortality i... |
S1083879120304079 | Recipients of allogeneic hematopoietic stem cell transplantation from unrelated donors and mismatched related donors typically have a higher incidence of acute and chronic graft versus host disease compared with matched related donors . Anti T cell globulins are often used to reduce GVHD in these recipients . We report... | A standardized protocol was implemented for peripheral blood stem cell allogeneic transplants for myeloid malignancies. Unrelated and mismatched donor recipients were given Thymoglobuline while matched related donors did not receive Thymoglobuline. Recipients from unrelated and mismatched donors had less chronic graft ... |
S1083879120304122 | Allogeneic hematopoietic stem cell transplantation can cure primary immunodeficiency diseases . When a HLA matched donor is not available a haploidentical family donor may be considered . The use of T cell replete haploidentical HCT with post transplantation cyclophosphamide in children with PID has been reported in fe... | We report the outcomes of 73 patients with PID after transplantation with a haploidentical donor graft and receipt of post transplantation cyclophosphamide haplo PTCy . Haplo PTCy can cure two thirds of PID patients and can be used to rescue graft failure after previous transplantation. Nonmyeloablative conditioning re... |
S1083879120304134 | The pharmacokinetics of low dose busulfan were investigated as a nonmyeloablative conditioning regimen for autologous gene therapy in pediatric subjects with adenosine deaminase deficient severe combined immunodeficiency disease . In 3 successive clinical trials which included either retroviral or lentiviral vectors su... | Low dose busulfan can open the bone marrow niche in the setting of gene therapy. Body surface area and weight based dosing resulted in variable busulfan plasma exposure. Therapeutic drug monitoring based dosing resulted in consistent plasma exposure. Busulfan clearance increased as subject age increased from birth to 1... |
S1083879120304146 | Chronic graft versus host disease is major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation . Ixazomib is an oral second generation proteasome inhibitor that has been shown in preclinical models to prevent GVHD . We conducted a phase I II trial in 57 patients to evaluate the safe... | Administration of an oral proteasome inhibitor ixazomib in combination with tacrolimus and methotrexate for prevention of chronic graft versus host disease GVHD is safe and convenient but failed to show efficacy when compared with contemporaneous matched Center for International Blood and Marrow Transplant Research con... |
S1083879120304389 | Long term therapy related reproductive health side effects impact the quality of life of hematopoietic stem cell transplantation survivors . In this study we evaluated the prevalence of gonadal dysfunction pre and post HSCT analyzed factors associated with GD and explored rates of fertility assessment and fertility pre... | Quality of life in hematopoietic stem cell transplantation HSCT survivors is impaired by reproductive outcomes. Fertility assessment and preservation must be prioritized at time of diagnosis. In both pre and post HSCT settings women are at higher risk of developing gonadal dysfunction. Low and middle income countries f... |
S1083879120304407 | Whiteboard videos are a popular video format allowing viewers to see drawings of concepts alongside explanatory text and speech . We hypothesized that whiteboard videos could support the education and recruitment of unrelated stem cell donors in Canada . A series of 5 sharable whiteboard videos about stem cell donation... | A series of whiteboard videos was developed to support stem cell donor education. Eligible donors from most needed donor demographics viewed the whiteboard video. The videos increased viewers objective and self reported knowledge about donation. The videos reduced viewers ambivalence toward donation. Use of the videos ... |
S1083879120304420 | Certain anaerobic bacteria are important for maintenance of gut barrier integrity and immune tolerance and may influence the risk of graft versus host disease after allogeneic hematopoietic stem cell transplantation . We conducted a single center retrospective cohort study of allogeneic HSCT recipients to evaluate asso... | Anaerobic antibiotics are associated with an increased risk of acute gut liver graft versus host disease GVHD . Piperacillin tazobactam and carbapenems deplete key gut anaerobes Clostridiales . Loss of butyrate biosynthesis genes from the gut precedes acute gut liver GVHD. |
S1083879120304432 | Allogeneic hematopoietic cell transplantation is the treatment of choice for acute myelogenous leukemia not responding to induction therapy . It is a therapeutic choice for the blast phase of chronic myelogenous leukemia in patients failing to respond to tyrosine kinase inhibitors . Lipid core nanoparticles concentrate... | A drug targeting vehicle was used for the first time in hematopoietic cell transplantation conditioning. Etoposide into nanoparticles plus total body irradiation showed low toxicity and safety. All patients had engrafted and no deaths occurred related to the conditioning regimen. Myeloablation engraftment and low toxic... |
S1083879120304444 | We investigated risk factors for the development of mixed chimerism in 131 patients who underwent transplantation for myelofibrosis and determined the impact of lymphoid and myeloid chimerism on transplant outcome . Disease risk included DIPSS plus categories low to high . The median patient age was 58 years . Patients... | Mixed CD3. chimerism is associated with reduced grafter versus host disease and improved relapse free survival. Mixed CD33. chimerism is associated with increased incidence of relapse. Mixed CD3. chimerism is not associated with risk of graft rejection. |
S1083879120304468 | Sickle cell disease is the most common inherited hemoglobinopathy . Hematopoietic stem cell transplantation is the sole curative therapy for SCD but few patients will have a matched sibling donor . Patients with SCD are mostly of African origin and thus are less likely to find a matched unrelated donor in international... | Patients with sickle cell disease SCD belong to ethnic groups underrepresented in donor registries. We assessed chances of finding a matched unrelated donor by geographical origin. Brazilian patients showed a greater genetic admixture than European Society for Blood and Marrow Transplantation patients. However chances ... |
S108387912030447X | Allogeneic hematopoietic cell transplantation for multiple myeloma with its underlying graft versus tumor capacity is a potentially curative approach for high risk patients . Relapse is the main cause of treatment failure but predictors for postrelapse survival are not well characterized . We conducted a retrospective ... | Time to relapse after T cell depleted hematopoietic cell transplantation defines distinct postrelapse outcomes. Relapse with extramedullary disease is common and associated with dismal prognosis. Donor lymphocyte infusion for relapse prevention improves postrelapse survival. |
S1083879120304493 | The indication for allogeneic stem cell transplantation in patients with lower risk myelodysplastic syndrome is controversial . Here we report 60 patients with a low risk or intermediate risk classification according to the revised International Prognostic Scoring System who underwent allogeneic SCT with a reduced inte... | Allogeneic stem cell transplantation SCT in patients with lower risk myelodysplastic syndrome MDS resulted in very good outcomes. Transplantation from a matched donor was a significant factor in survival. The risk of relapse risk is 10 in patients with lower risk MDS after allogeneic SCT. |
S108387912030450X | Autologous hematopoietic cell transplantation is a standard initial treatment for multiple myeloma . Consensus guidelines recommend collecting sufficient hematopoietic progenitor cells for 2 autoHCTs in all eligible patients . Despite a lack of published data on the utilization of HPCs stored for future use it is commo... | In the majority of patients with multiple myeloma hematopoietic progenitor cells HPCs collected at the time of first autologous hematopoietic cell transplantation autoHCT are not used for a future salvage autoHCT or stem cell boost. The evidence supporting continued collection HPCs for later use in patients age 70 year... |
S1083879120304511 | The use of myeloablative conditioning in the setting of active relapsed refractory acute myeloid leukemia has been hindered by high historical rates of nonrelapse mortality . FLAMSA chemotherapy followed by reduced intensity conditioning has been proposed as an effective and potentially safer alternative in this scenar... | FLAMSA fludarabine Ara C and amsacrine sequential chemotherapy followed by total body irradiation TBI based reduced intensity conditioning RIC and myeloablative conditioning MAC led to similar transplantation outcomes in relapsed refractory active acute myeloid leukemia. FLAMSA sequential chemotherapy followed by TBI f... |
S1083879120304523 | With post transplantation cyclophosphamide as graft versus host disease prophylaxis nonmyeloablative HLA haploidentical and HLA matched blood or marrow transplantation have comparable outcomes . Previous reports have shown that discontinuation of immunosuppression as early as day 60 after infusion of a bone marrow hapl... | This safety and feasibility study of haploidentical peripheral blood transplantation and unrelated donors demonstrates that a substantial subset of patients can discontinue immunosuppression as graft versus host disease prophylaxis as early as day 60. Shortened duration immunosuppression may decrease the risk of relaps... |
S1083879120304535 | Infection is a major cause of morbidity and mortality after hematopoietic cell transplantation . Gut microbiota composition and metabolites provide colonization resistance against dominance of potential pathogens and GM dysbiosis following HCT can be deleterious to immune reconstitution . Little is known about the comp... | Significant changes in gut microbiota GM diversity were detected over time from baseline to hematopoietic recovery during hematopoietic cell transplantation HCT . GM functional profiles differed between patients who developed febrile neutropenia and those who did not. We identified a baseline protective GM profile that... |
S1083879120304559 | Accurate prognostic tools are crucial to assess the risk benefit ratio of allogeneic hematopoietic cell transplantation in patients with myelofibrosis . We aimed to evaluate the performance of the Myelofibrosis Transplant Scoring System and identify risk factors for survival in a multicenter series of 197 patients with... | The Myelofibrosis Transplant Scoring System MTSS model failed to clearly delineate 4 risk groups in our series. The MTSS can still be useful to identify a high risk category with poor outcome. Comorbidities donor type and post transplant cyclophosphamide PT Cy predict survival after hematopoietic cell transplantation. ... |
S1083879120304572 | Previous studies have reported a beneficial effect from cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation on immune reconstitution . We determined the CMV antigenemia level associated with increased CMV antigen specific T cells at day 100 and decreased CMV reactivation after day 100 ... | Cytomegalovirus CMV reactivation induces CMV antigen specific T cells which may prevent subsequent CMV reactivation. Low level CMV antigenemia 5 50 000 polymorphonuclear cells positive for pp65 associates with protective anti CMV immunity after day 100 and may be beneficial. Early therapy of low level CMV antigenemia c... |
S1083879120304584 | The use of myeloablative conditioning in umbilical cord blood transplantation has been associated with high nonrelapse mortality in patients aged 40 years especially those having a high HLA disparity thus limiting wider applications . We hypothesized that the NRM advantage of reduced intensity conditioning and higher g... | In HLA mismatched umbilical cord blood transplantation UCBT reduced intensity conditioning provided comparable results to myeloablative conditioning for patients with acute myeloid leukemia AML aged 40 to 60 years. The main factor associated with poor outcomes after HLA mismatched UCBT was advanced disease status. UCBT... |
S1083879120304596 | Cyclosporine combined with short course methotrexate is considered standard of care graft versus host disease prophylaxis for patients with severe aplastic anemia who undergo transplantation using cyclophosphamide plus anti thymocyte globulin conditioning . However there is no consensus on optimal post transplant GVHD ... | Graft versus host disease GVHD often leads to post transplant morbidity and mortality and can severely compromise quality of life. Cyclosporine combined with short course methotrexate is considered standard of care GVHD prophylaxis for patients with severe aplastic anemia who undergo transplantation using cyclophospham... |
S1083879120304614 | Total body irradiation cyclophosphamide is a standard of care conditioning regimen in allogeneic hematopoietic stem cell transplant for pediatric acute lymphoblastic leukemia . This study sought to identify whether the addition of thiotepa to TBI CY improves HSCT outcomes for pediatric patients with ALL . A retrospecti... | Thiotepa is safe to use with a total body irradiation TBI cyclophosphamide backbone in pediatric patients with acute lymphoblastic leukemia with no increase in transplant related mortality. Addition of thiotepa to TBI cyclophosphamide did not significantly impact relapse or disease free survival in pediatric acute lymp... |
S1083879120304638 | Angiotensin II type 1 receptor activating autoantibodies have gained attention in solid organ transplant as non HLA antibodies associated with rejection vasculopathy and graft dysfunction . These antibodies have also been reported in the context of pre eclampsia scleroderma and isolated hypertension . Here we present 3... | Patients are at risk of developing angiotensin II type 1 receptor activating autoantibodies AT1R AAs in the post hematopoietic stem cell transplant period. AT1R AAs can drive hypertension refractory to non angiotensin receptor blockade ARB therapies. AT1R AAs may play a role in intestinal graft versus host disease path... |
S108387912030464X | Although allogeneic hematopoietic stem cell transplantation is the key strategy to cure patients with mature T and natural killer cell lymphomas leukemia especially those with relapsed refractory diseases there is no consensus strategy for donor selection . We retrospectively analyzed the outcomes of allo HSCT in 111 p... | Allogeneic hematopoietic stem cell transplantation is beneficial for patients with mature T cell and natural killer cell neoplasms. Cord blood transplantation CBT resulted in favorable outcomes with a lower risk of relapse. CBT could be a preferred option especially for patients with uncontrolled diseases. Better contr... |
S1083879120304651 | Ruxolitinib a selective Janus kinase 1 2 inhibitor has recently been proposed for steroid refractory chronic graft versus host disease after allogeneic hematopoietic stem cell transplantation particularly in severe skin cGVHD . Lung function impairment is common in severe skin cGVHD through concomitant bronchiolitis ob... | Ruxolitinib had no effect on respiratory function in patients with severe skin chronic graft versus host disease. Forced expiratory value over 1 second FEV. decreased significantly over time independent of exposure to ruxolitinib. FEV. trajectory was similar in exposed and unexposed patients. |
S1083879120304675 | We assessed differences in presentation and response to therapy in 394 consecutive patients who developed acute or chronic graft versus host disease after receiving their first allogeneic transplantation from a 10 10 HLA allele matched unrelated donor using calcineurin inhibitors or a T cell replete haploidentical dono... | Haploidentical transplantation haplo with post transplantation cyclophosphamide PTCY is associated with a lower incidence of chronic graft versus host disease GVHD compared with matched unrelated donor MUD transplantation using calcineurin inhibitor based GVHD prophylaxis. Haplo with PTCY has faster onset of chronic GV... |
S1083879120304699 | The outcomes of 7 8 allele matched unrelated bone marrow transplantation and umbilical cord blood transplantation have been improving . We retrospectively analyzed adults with acute leukemia who underwent their first 7 8 UBMT or UCBT in Japan . Between January 2008 and December 2017 a total of 4150 patients were record... | Hematopoietic stem cell transplantation with 7 8 HLA allele matched unrelated bone marrow 7 8 UBMT and umbilical cord blood UCBT make use of alternative donor sources for patients with acute leukemia who lack HLA identical donors. This report provides an updated comparison of 7 8 UBMT and UCBT in a Japanese nationwide ... |
S1083879120304705 | Long driving distances to transplantation centers may impede access to care for hematopoietic cell transplantation survivors . As a secondary analysis from the multicenter INSPIRE study we examined baseline data from relapse free HCT adult survivors to investigate the association between driving distances and patient r... | Distances from hematopoietic cell transplantation HCT centers exceed 100 miles for 44 of survivors. We examined driving distances distress and physical function among HCT survivors. Chronic graft versus host disease and low income predicted worsened distress and function. Interestingly lack of Internet access also pred... |
S1083879120304730 | There is a paucity of information about nutrition in chronic graft versus host disease . The role of nutrition is important because malnutrition is strongly associated with severe chronic GVHD manifestations . There is a high prevalence of metabolic syndrome and osteoporosis in this setting . Here we review the literat... | There are few studies on nutrition and chronic graft versus host disease GVHD . Many drugs used to treat chronic GVHD can lead to nutritional problems and metabolic syndrome. Monitoring and early nutritional measures of metabolic syndrome osteoporosis and loss of muscle mass could improve outcome and response to treatm... |
S1083879120304754 | Increasingly adolescent young adult and adult children are relied upon as donors for their parents undergoing blood and marrow stem cell transplant . How family functioning impacts donors decision making and whether haploidentical donor children have unique supportive care needs is unknown . In this qualitative researc... | This is the first study to describe haploidentical child donor perspectives. Despite relational strains family functioning rarely affected decisions to donate. Participants felt satisfied by decision and ability to give back to their parent. Additional educational emotional support is needed to improve donor experience... |
S1083879120305048 | A paucity of randomized phase III clinical trials in primary central nervous system lymphoma has resulted in no uniform consensus on the optimal strategy for consolidation and conditioning regimens for autologous stem cell transplant . The past 2 decades have witnessed a preference for thiotepa based conditioning regim... | Primary central nervous system CNS lymphoma is a rare entity with limited randomized clinical trials. No consensus exists on the optimal consolidation strategy and conditioning regimen in primary CNS lymphoma. Our 20 year experience at the Mayo Clinic Rochester provides additional insights. Disease response before tran... |
S108387912030505X | Granulocyte colony stimulating factor is administered after allogeneic hematopoietic cell transplantation to aid neutrophil recovery . We compared the effect of empiric G CSF administration on the duration of index inpatient hospitalization stay after HCT for patients aged 18 years with a hematologic malignancy . G CSF... | Empiric granulocyte colony stimulating factor G CSF therapy shortens the duration of in patient stay after HLA matched unrelated donor transplantation. Empiric G CSF therapy does not shorten the duration of in patient stay after HLA matched sibling transplantation. Empiric G CSF therapy is not associated with early sur... |
S1083879120305061 | Allogeneic hematopoietic stem cell transplantation is a valid option in patients with refractory lymphomas . HLA haploidentical stem cell transplantation expanded the accessibility to allogeneic hematopoietic cell transplantation . The aims of study were to retrospectively assess the toxicity and efficacy of haplo SCT ... | Nonmyeloablative haploidentical stem cell transplantation for advanced lymphomas is highly feasible with low incidence of nonrelapse mortality. It provides a strong graft versus lymphoma effect for both Hodgkin and non Hodgkin lymphoma with low incidence of relapse when performed in partial or complete remission. |
S1083879120305073 | Ruxolitinib is an oral JAK1 2 inhibitor that is approved for use in patients with intermediate and high risk myelofibrosis based on its proven spleen and symptom burden reduction . Its impact on hematopoietic stem cell transplantation outcomes is largely unknown however . A significant number of patients proceeding to ... | A tapering strategy should be used to discontinue ruxolitinib in transplant recipients. Ruxolitinib should be continued until conditioning given the risk of cytokine rebound. Ruxolitinib is well tolerated if continued through conditioning therapy and until engraftment. Patients on ruxolitinib must be monitored closely ... |
S1083879120305085 | Multiple investigations have documented the health related quality of life and donation related experiences of unrelated donors but similar investigations of the related donor experience have been less common . The central goal of this study was to longitudinally examine and compare HRQoL of RD and URD hematopoietic st... | Related donors were more certain about and satisfied with the decision to donate. Related donors experienced more pain and symptoms related to donation. Related donors were less likely to be fully recovered at 1 year postdonation. |
S1083879120305097 | For patients with relapsed or refractory classical Hodgkin lymphoma salvage chemotherapy followed by consolidation with autologous stem cell transplant remains the standard of care . Even with this aggressive treatment strategy 5 year progression free survival is 50 and there remains interest in maintenance strategies ... | We performed a pilot clinical trial to determine the feasibility of maintenance lenalidomide after autologous stem cell transplant in relapsed refractory classical Hodgkin lymphoma rel ref cHL . An unexpectedly high frequency of hematologic toxicities resulting in early lenalidomide discontinuation was observed. The le... |
S1083879120305115 | Fanconi anemia is the most common inherited bone marrow failure syndrome and hematopoietic stem cell transplantation is the only curative option . Post transplant cyclophosphamide is challenging in this group of children given their increased sensitivity to chemotherapy . We performed a retrospective analysis of the da... | Haploidentical stem cell transplantation with post transplant cyclophosphamide can be considered a viable option in children with Fanconi anemia particularly in resource limited settings given the high costs of hematopoietic stem cell transplantations with an overall survival of 68.4 . Peripheral blood stem cells provi... |
S1083879120305395 | To review the updated trends of national practice and outcomes in transplantation to treat myelofibrosis we retrospectively evaluated 142 patients who underwent allogeneic hematopoietic stem cell transplantation for primary or secondary MF at an Australian New Zealand transplantation center between 2006 and 2017 . The ... | We report updated trends in allogeneic stem cell transplantation for myelofibrosis in Australasia. We identify pretransplantation factors influencing post transplantation outcomes. There has been limited uptake of molecular genomic technology in Australasia. Long term outcomes of patients reported in the previous ABMTR... |
S1083879120305401 | The pulmonary function test is an important test for risk stratification before allogeneic transplantation . However it might be preferable to avoid PFT as much as possible in the recent era of coronavirus disease 2019 because PFT requires forced expirations and might produce aerosols increasing the risk of COVID 19 tr... | The pulmonary function test PFT is an important test for risk stratification before allogeneic hematopoietic stem cell transplantation allo HCT although it might be preferable to avoid unnecessary PFT during the COVID 19 pandemic. Our computed tomography CT based model for predicting normal PFT showed relatively high s... |
S1083879120305413 | Recent progress in genetic analysis technology has helped researchers understand the pathogenesis of acute myeloid leukemia . Considering this progress AML karyotype is still one of the most significant prognostic factors that provides risk adapted treatment approaches . Karyotype changes during treatment have been obs... | Effect of acute myeloid leukemia karyotype on the outcomes of allogeneic stem cell transplantation was tested. Cytogenetic evolution affects prognosis after allogeneic stem cell transplantation. |
S1083879120305437 | BiCNU etoposide Ara C melphalan and Campath conditioning was developed to reduce the high transplant related mortality in patients with lymphoma while delivering intensive antilymphoma immunotherapy as well as to some extent a platform for allogeneic stem cell engraftment . Significant numbers of patients appeared to h... | BEAM Campath allografts for lymphoma achieve long term disease free survival. One third of patients developed myeloid mixed donor recipient chimerism. T cell mixed chimerism occurred in 62 and was associated with reduced nonrelapse mortality. Neither T cell or myeloid mixed chimerism is associated with increased relaps... |
S1083879120305747 | High dose melphalan conditioning before autologous hematopoietic cell transplantation is standard of care for patients with transplantation eligible multiple myeloma . The traditional lyophilized Mel formulation has inadequate solubility and stability after reconstitution leading to the use of propylene glycol as a sol... | Propylene glycol PG free melphalan PGF Mel Evomela is safe and has similar toxicity profile as PG Mel Alkeran when used as a conditioning regimen for autologous hematopoietic cell transplantation autoHCT for myeloma patients. PGF Mel conditioning was associated with a modest improvement in neutrophil recovery median 12... |
S1083879120305759 | Transplant associated thrombotic microangiopathy is a systemic vascular illness associated with significant morbidity and mortality resulting from a convergence of risk factors after allogeneic blood or marrow transplantation . The diagnosis of taTMA has been a challenge but most criteria include an elevated lactate de... | Transplant associated thrombotic microangiopathy taTMA is a serious complication of allogeneic bone marrow transplantation. The incidence of taTMA is low at 1.4 using post transplant cyclophosphamide PTCy based graft versus host disease prophylaxis. Recipient donor mismatch is unlikely to be a risk factor when PTCy is ... |
S1083879120305784 | Delirium is common among adults undergoing hematopoietic stem cell transplantation although the clinical and neuroimaging correlates of post HCT delirium have not been adequately delineated . We therefore examined the frequency of delirium and neuroimaging correlates of post transplant delirium in a retrospective cohor... | Delirium is common following hematopoietic stem cell transplantation. In this select sample greater age treatment regimen intensity and greater white matter burden were all associated with greater delirium incidence. |
S1083879120305802 | The use of potentially inappropriate medications using Beers criteria and its impact on older allogeneic hematopoietic cell transplantation recipients is not known . Here the use of any PIMs and their therapeutic classes in reduced intensity conditioning allogeneic HCT recipients were compared between older and younger... | The rate of potentially inappropriate medication PIM use was similar in older and younger recipients of allogeneic hematopoietic cell transplantation HCT . Females high risk Hematopoietic Cell Transplantation Comorbidity Index and umbilical cord blood recipients had higher use of PIMs. In recipients age 65 years PIM us... |
S1083879120305851 | Hematopoietic cell transplantation is an effective treatment for many hematologic malignancies and its utilization continues to rise . However due to the difficult logistics and high cost of HCT there are significant barriers to accessing the procedure these barriers are likely greater for older patients . Although num... | There are significant barriers to accessing hematopoietic cell transplantation HCT . High quality studies are lacking related to HCT barriers. Older age and nonwhite race were consistently linked to reduced access to HCT. Strategies to overcome these barriers for these vulnerable populations should be prioritized. |
S1083879120305942 | In this cross sectional study we retrospectively evaluated the files of 227 patients with myelofibrosis who underwent transplantation between 1994 and 2015 for relapse later than 5 years after allogeneic stem cell transplantation . A total of 94 patients who were alive and in remission at 5 years were identified with f... | Late relapse after 5 years occurs in about 14 of myelofibrosis patients after allogeneic stem cell transplantation allo SCT . For detection chimerism and minimal residual disease monitoring should be performed even beyond 5 years after allo SCT. Most relapses can be successfully salvaged by donor lymphocyte infusion an... |
S1083879120305954 | Severe aplastic anemia is a life threatening disease that can be cured with allogeneic cell transplantation . Haploidentical donor transplantation with post transplantation cyclophosphamide is an option for patients lacking an HLA matched donor . We analyzed 87 patients who underwent haplo PTCy between 2010 and 2019 . ... | Hematopoietic stem cell transplantation from haploidentical donors for relapsed refractory severe aplastic anemia is feasible. Primary graft failure was 15 2 year event free survival EFS was 70 and 2 year overall survival was 79 . An augmented cyclophosphamide fludarabine total body irradiation regimen is associated wi... |
S1087184518301804 | MicroRNAs are endogenous noncoding RNAs that can regulate gene expression . However little information is known about milRNAs and their target genes in | For the first time Identied the milRNAs and their targets experimentally in. Identified many miRNA features that may be unique to basidiomycetes. The milRNAs functions are developmental stages dependent. Different mechanism of regulation for miRNA might be present. Conserved miRNA biosynthesis and processing machinerie... |
S1087184519300404 | Cadmium is a heavy metal present in the environment mainly as a result of industrial contamination that can cause toxic effects to life . Some microorganisms as | tolerates well cadmium exposure although the metal impairs its growth. Genes related to transport glutathione and nitrogen metabolism were up regulated. RNA processing was strongly induced especially components of spliceosome. Carbohydrate metabolism genes related to mycoparasitism were repressed. |
S1087184519300878 | Proteinaceous infectious particles causing mammalian transmissible spongiform encephalopathies or prions are being extensively studied . However due to their hazardous nature the initial screening of potential anti prion drugs is often made in a yeast based screening system utilizing a well characterized | A novel. prion in. was created. prion was used to make a new screening system for anti prion drugs. based screening assay is safe cost efficient and easy to use. |
S1087184519301082 | Modern genome analysis and phylogenomic methods have increased the number of fungal species as well as enhanced appreciation of the degree of diversity within the fungal kingdom . In this context we describe a new | A new Hypocreales fungal species. is proposed. is phylogenetically related the opportunistic fungal pathogen. The genome of. was sequenced assembled and annotated. Comparative genomic studies of Hypocreales reveals unique metabolic profile. Molecular tools complement traditional morphologic fungal species discovery. |
S1087184519301094 | Transmembrane proteins as sensors encoded by fungal genes activate specific intracellular signal pathways in response to stress cues to help the fungus survive in a changing environment . To better understand the role of the cell wall integrity pathway in the entomopathogenic fungus | The significance of. in dimorphic transition conidium and microsclerotium formation. The. mediated regulation of target genes involved in microsclerotium development. It provides valuable understanding the molecular mechanism of microsclerotium development. |
S1087184519301288 | Protein O mannosyltransferases have been identified in fungi but not in plants and nematodes which makes PMTs become attractive targets for developing a new strategy against phytopathogens . Three PMTs have been identified in | Protein O mannosylaion is catalysed by three protein O mannosyltransferases PMT1 PMT2 and PMT4 in. Deletion of each. gene induces differential phenotype and attenuated virulence. Comparative glycoproteomics analysis reveals that different PMTs act on different protein substrates. |
S108718451930129X | Ras GTPases are nucleotide hydrolases involved in key cellular processes . In fungi Ras GTPases regulate conidiation development virulence and interactions with other fungi or plants . | TBRG 1 belongs to a new family of Ras GTPases named the Big Ras GTPases family. The lack of. impairs the conidiophore development in. and therefore the conidiation process. TBRG 1 is a negative regulator of antibiosis and mycoparasitism in. TBRG 1 is necessary to provide the biocontrol capability to. against |
S1087184519301483 | Chitinases the enzymes responsible for the biological degradation of chitin participate in numerous physiological processes such as nutrition parasitism morphogenesis and immunity in various organisms . However the genome wide distribution evolution and biological functions of chitinases are rarely reported in oomycete... | GH18 chitinases were widely distributed in oomycetes. is required for zoospore production. and. regulate oxidative stress response and virulence. GH18 chitinases play diverse roles in |
S1087184519301665 | The presence of commensal fungal species in the human gut indicates that organisms from this kingdom have the potential to benefit the host as well . | Yeasts can form an important part of the human mycobiome as probiotics. is a well characterized probiotic yeast often used to alleviate GI tract disorders. Several pre clinical and clinical trials have demonstrated its efficacy as a probiotic. Several genome engineering tools available for. can be applied. to improve i... |
S1087184519301793 | is the main causal agent of fusarium head blight of wheat and barley . This filamentous fungus is able to produce hydrolytic enzymes such as xylanases that cause cell wall degradation permitting host colonization . This study investigated the role of the | showed a role on. virulence during host colonization. was important for fungal growth on heads during the first FHB infection stages. Two genes encoding other xylanases did not show an overexpression in the absence of |
S1087184519302038 | The detrimental effect of fungal pathogens on forest trees is an increasingly important problem that has implications for the health of our planet . Despite this the study of molecular plant microbe interactions in forest trees is in its infancy and very little is known about the roles of effector molecules from forest... | and. share effector genes. In. many of these are pseudogenized or are poorly expressed. All these effectors are polymorphic among global. isolates. DsEcp2 1 triggers cell death in a non host plant and restricts. growth in pine. These results suggest both pathogen and host adaptation at the molecular level. |
S1087184519302142 | has been employed in the industrial production of cephalosporin C . However there are still some impediments to understanding the regulation of CPC biosynthesis and improving strains due to the difficulty of genetic manipulation in | An improved CRISPR Cas9 system based on a chimeric promoter. This system shows a high efficiency for gene disruption in. A large DNA fragment was deleted at a high efficiency by the system. Blocking the sorbicillinoid biosynthesis increases the CPC production. |
S1087184519302439 | Biotrophic basidiomycete plant pathogens cause billions of dollars in losses to cereal crops annually . The model for this group of fungi is the corn smut pathogen | and. ectopic expression did not complementdeletion phenotype. Deletion of. reduces pathogenesis similarly to P. or. deletion. deletion lack of growth on xylose complemented but not pathogenesis phenotype. codes a putative xylitol dehydrogenase not directly regulated by. Altered expression of antisense transcripts may i... |
S1087184519302476 | Regulation of plant cell wall degradation is of utmost importance for understanding the carbon cycle in nature but also to improve industrial processes aimed at enzyme production for next generation biofuels . Thereby the transcription factor networks in different fungi show conservation as well as striking differences... | Functions of CLR1 and CLR2 in plant cell wall degradation are rewired in. Deletion of clr1 or clr2 breaks coregulation of xylanase genes on xylan. CLR1 and CLR2 form a positive regulatory feedback loop on xylan. |
S1087184519302609 | Septins are highly conserved GTP binding proteins that function in cell cytokinesis polarity and morphogenesis . To evaluate the roles of these proteins in inoculum health and disease mutants deleted for each of five septin proteins were characterized in the ascomycete | The first functional study of the four core septin genes in a Dothideomycete plant pathogen Dothideomycetes is the largest group of phytopathogens. Development of sexual reproductive propagules was impacted in. core. mutants. Wild type asci formed but ascospores appeared to be blocked in the meiotic process and never f... |
S1087184519302683 | The HOG pathway is critical for the appropriate adaptation to adverse conditions . Here we demonstrated that the deletion of | Cg. null mutants displayed enhanced sensitivity to osmotic stress. The deletion of. resulted in increased resistance to fludioxonil. Compatible solutes contribute to the. dependent osmoadaptation. Vesicle trafficking related genes were highly downregulated in the. strain. |
S1087184519302786 | Trichothecenes are among the mycotoxins of most concern to food and feed safety and are produced by species in two lineages of | Tri21 is a transcription factor that regulates trichothecene biosynthesis. Tri21 regulates expression of late but not early trichothecene pathway genes. cluster acquired. gene after divergence from other. clusters. cluster has diverged into two lineages one with and one without. gene regulation differs in two trichothe... |
S1087184519302890 | The fungal cell wall consists of proteins and polysaccharides formed by the co ordinated activity of enzymes such as chitin or glucan synthases . These enzymes are delivered via secretory vesicles to the hyphal tip . In the ascomycete | Native chitin Chs5 and glucan synthase Gsc1 visualised in the pathogen. Chs5 and Gsc1 are transported along microtubules. Chs5 and Gsc1 do localise to the apical plasma membrane but not the Spitzenkrper. Light and electron microscopy how co travel of Chs5 and Gsc1 in the same secretory vesicle. Enzyme delivery in. is d... |
S1087184519303032 | The endoplasmic reticulum is composed of distinct structural domains that perform diverse essential functions including the synthesis of membrane lipids and proteins of the cell endomembrane system . The polarized growth of fungal hyphal cells depends on a polarized secretory system which delivers vesicles to the hypha... | An ER domain is associated with the polarized growing apical cells of hyphae. The apical ER domain consists of dynamic and pleomorphic ER sub compartments. The apical ER sub compartments undergo fusion and division events. The apical ER sub compartments display acropetal and basipetal displacements. |
S1087184519303287 | The cell wall is a distinctive feature of filamentous fungi providing them with structural integrity and protection from both biotic and abiotic factors . Unlike plant cell walls fungi rely on structurally strong hydrophobic chitin core for mechanical strength together with alpha and beta glucans galactomannans and gly... | cell wall chitin mutant characterized by co segregation analysis. GDP dissociation inhibitor A. was identified as an essential gene. Intronic SNPs in cell wall mutant. cause inefficient splicing. CRISPR Cas9 genome editing was successfully used to reconstitute mutant. SNPs. The. mutant allele is a candidate for GdiA re... |
S1087184519303299 | Histone deacetylases play essential roles in modulating chromatin structure to provide accessibility to gene regulators . Increasing evidence has linked HADCs to pathogenesis control in the filamentous plant fungi . However its function remains unclear in | FpDep1 is a component of the Rpd3L histone deacetylase complex in. is essential for vegetative development and pathogenicity in. The. gene represses reactive oxygen species ROS accumulation. The Fpdep1 mutant is delayed in endocytosis. |
S1087184519303366 | Sexual reproduction is a highly conserved feature of the eukaryotes yet sexual compatibility is determined by a wide variety of mechanisms . In ascomycete fungi sexual development is controlled by genes at the mating type | A genome editing protocol has been developed for use in. species. a novel mating gene is a true mating gene in. strains show delays in protoascomatal development and hyphal growth. is essential for ascomatal maturation. |
S1087184520300086 | Nitric oxide can be biologically synthesized from nitrite or from arginine . Although NO is involved as a signal in many biological processes in bacteria plants and mammals still little is known about the role of NO in fungi . Here we show that NO levels are regulated by light as an environmental signal in | NO levels are regulated by light. Phytochrome A is required for induction by light of flavohemoglobin B and arginase. The blue photoreceptor LreA represses both genes in the presence of arginine. Intracellular arginine levels are regulated during development. Deletion of. results in loss of light regulation of conidiat... |
S1087184520300372 | MicroRNAs play important roles in various cellular growth and developmental processes through post transcriptional gene regulation via mRNA cleavage and degradation and the inhibition of protein translation . To explore if miRNAs play a role in appressoria formation and virulence that are also governed by the regulator... | MicroRNA like milR236 targets the sequence encoding MoHat1. milR236 overexpression induces delayed appressorium formation and virulence attenuation. milR236 expression is regulated by the transcription factor MoMsn2. |
S1087184520300438 | Small GTPases of the ADP ribosylation factor family and their activating proteins regulate mycelial development and pathogenicity in yeast and filamentous fungi however little is known about their roles in nematode trapping fungi . In this study an ortholog of Arf GAP Glo3 in | AoGlo3 is the ortholog of yeast Glo3 and a pleiotropic regulator in. AoGlo3 is indispensable for conidiation trap formation and nematode trapping. AoGlo3 contributes to mycelial growth and environmental adaption. AoGlo3 is required for endocytosis and autophagy. |
S1087184520300566 | Green fluorescent protein and its counterparts are modern molecular biology research tools indispensable in many experimental systems . Within fungi researchers studying | Fluorescent proteins are valuable molecular biology research tools however only handful are available in. Eight fluorescent proteins were identified and expressed with five highly visible under the microscope. Heterologous expression of these five bright fluorescent proteins within. does not influence virulence. Develo... |
S108718452030058X | Filamentous fungi are well known for producing secondary metabolites applied in various industrial segments . Among these lovastatin and itaconic acid produced by | Evaluation of 35. strains isolated from Brazil for lovastatin and itaconic acid production. Molecular identification enabled to separate the 35 Aspergillus terreus strains in three monophyletic groups. Lovastatin production stands out in the monophyletic group. B. There is no specific monophyletic group for itaconic ac... |
S1087184520300591 | Ergosterol is the most important membrane sterol in fungal cells and a component not found in the membranes of human cells . We identified the | Erg6 is required for. high temperature growth. deletion impairs susceptibility to stress and antifungal agents. Sterol membrane composition affects virulence of human fungal pathogen. |
S1087184520300694 | This work presents the identification and proposed biosynthetic pathway for a compound of mixed polyketide nonribosomal peptide origin that we named acurin A . The compound was isolated from an extract of the filamentous fungus | A biosynthetic gene cluster for the hybrid polyketide nonribosomal peptide compound acurin A in. The PKS and NRPS responsible for acurin A production are two individually transcribed entities. Phylogenetics suggest that the separated PKS and NRPS is a result from the fission of an ancestral PKS NRPS hybrid. The biosynt... |
S1087184520300864 | Paracoccidioidomycosis is a life threatening systemic mycosis widely reported in the Gran Chaco ecosystem . The disease is caused by different species from the genus | Paracoccidioidomycosis is a systemic mycosis reported in the Gran Chaco ecosystem. and. were found in Argentina and Paraguay. S1a specimens from Argentina are associated with chronic forms. In Paraguay. S1b was only the genotype observed. The coexistence of these species in a common area suggests reproductive isolation... |
S1087184520300876 | The ubiquitin proteasome system is critical for the regulation of protein turnover which is implicated in the modulation of a wide array of biological processes in eukaryotes ranging from cell senescence to virulence in plant and human hosts . Proteins to be marked for ubiquitination and subsequent degradation are boun... | Skp1 Cul1 F box SCF complexes regulate protein degradation in eukaryotes. encoding genes have been identified in. and. SkpA interacts with F box proteins to form SCF complexes in. species. SCF complex conformations vary in response to different exogenous stresses. In both species Fbx45 interacts with SkpA in the presen... |
S108718452030089X | Evolution favors the emergence of locally adapted optimum phenotypes that are likely to differ across a wide array of environmental conditions . The emergence of favorable adaptive characteristics is accelerated in agricultural pathogens due to the unique properties of agro ecosystems . We performed a Q | QST FST study of 164 strains using image phenotyping and full genome sequences. Natural selection and genetic drift on quantitative traits. Local adaptation against fungicides and high temperatures among populations. Melanization was found to be under stabilizing selection. Trade off between melanization and growth rat... |
S1087184520300906 | Subtilases are a large family of serine proteases that occur throughout biology . A small subset contain protease associated domains that are structurally separate from but encoded within the active site . In bacteria subtilase PA domains function to recruit specific protein substrates . Here we demonstrate that a prot... | We identified a protease secreted by. a fungal corn pathogen. Kilbournase truncates corn ChitA chitinase cleaving the N terminus multiple times. Kilbournase resembles. ScpA which targets human C5a. Kilbournase and ScpA are PA domain subtilases that target specific host proteins. Kilbournase is the first protein implica... |
S1087184520300918 | Endocytosis plays critical roles in cellular processes including nutrient uptake and signal transduction . Ede1 is an endocytic scaffolding protein that contributes to endocytic site initiation and maturation in yeast . However the functions of Ede1 in phytopathogenic fungi are not known . Here we identified functions ... | deletion causes reduced hyphal growth and conidiation. is essential for full virulence. deletion mutant shows tolerance to various stresses. deletion displays the aggravated autophagy. |
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